What Is Ozone Therapy: Immune-Boosting Oxygen Treatment

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By Dr. Justin Marchegiani

Ozone (O3) is a potent form of oxygen composed of three oxygen atoms. Ozone is both a natural and man-made gas. In nature, ozone is formed naturally through both lightning and the interaction of ultraviolet radiation from the sun with molecular oxygen (O2). The ozone layer, the range which spans about 6-30 miles above the Earth's surface, reduces the amount of harmful UV radiation that reaches us at the surface level.

Ozone therapy has been used in medicine since World War 1, though it lacks sufficient research to have made it into the mainstream. Ozone is the strongest naturally occurring oxidant. From the research that has been done on ozone therapy, it has been found to be an effective tool in modulating the immune system, enhancing circulation, destroying bacteria and viruses, and enhancing oxygen delivery by the body.

Benefits of Ozone Therapy

Medical ozone disinfects and destroys microorganisms including bacteria, viruses, fungi, yeast and protozoa.

The cells that are most susceptible to foregin invasion or infection by pathogens are also the most vulnerable to oxidation. With the use of ozone therapy, ozone destroys cell growth by disrupting cell growth, thereby eliminating the pathogen.

Research has shown promising results in the following conditions though the therapeutic use of ozone:

Antibacterial and Antifungal 

Ozone has antibacterial and antifungal properties that make it a good choice for treating infections and wounds. Ozone gets inside the cell walls of bacteria and fungi to oxidize and destroy the lipids within. In fact, ozone has also been demonstrated to destroy biofilms, which are notoriously hard to treat. This implies ozone may be a useful treatment in cases where antibiotics fail– like against resilient microbial infection where biofilm is present.

Boosted Immune Response

Ozone is a potent immune system modulator–meaning when the immune system is in overdrive (like with autoimmune diseases) it will calm it down, and when the immune system is under-active it will stimulate it–like with cancer and chronic infections. 


Ozone increases antioxidant production more than any other therapy else we know of, including vitamin C. Ozone works by increasing endogenous production of antioxidants (production stemming from within the body).

Increased Oxygen Efficiency

Ozone stimulates increased oxygen uptake, which has very good implications for diabetics.

Improved Circulation

Ozone improves circulation and enables more oxygen to reach the capillaries; therefore providing cells with more oxygen. Those with chronic inflammation tend to have weak circulation.

Ozone Safety Precautions

Ozone is an unstable molecule, and therefore there are risks. Ozone therapy is not currently approved by the FDA, and therefore healthcare practitioners within the United States cannot perform this therapy on patients, although there are many researchers and doctors who believe this powerful therapy warrants further study.

While ozone can be dangerous, when administered correctly it has several healing benefits. Therapeutic dosage of ozone gas can be administered any of the following ways:

Auto-Hemotransfusion: Blood is drawn from the body, mixed with ozone gas, then reintroduced to the body.

Injection: Intravenous or intramuscular injections.

Internally: Ozone dissolved into water as a medicinal drink.

Rectal Insufflation: Ozone gas administered through the rectum.

Topically: Ozone gas can be administered directly to the skin through a sealed bag or special medical chamber.


While ozone therapy is not currently FDA-Approved, and there are certainly risks if it is misused, the benefits surely warrant further research. 




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