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The Top 5 Nutrients to Address Gut Inflammation and Leaky Gut | Podcast #339

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Whenever you are worried about your gut health and having inflammation, Dr. J and Evan are here to share five essentials that may help you.

Lessen your intake of highly processed foods, refined carbs, sugar, artificial sweeteners, and alcohol. Opt instead for anti-inflammatory foods like fruits, vegetables, spices, and healthy fats but, if you suspect that several foods are triggering inflammation in your gut, it might be worth giving an elimination diet a try.

It may require removing foods from your diet that you suspect are connected to your gut problems for roughly two to three weeks at a time. Inflammation in your gut may cause a host of harmful health symptoms, from fatigue to irregular periods and chronic constipation. However, a few changes to your diet and lifestyle might be vital to helping you control these symptoms and improve your gut health.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this podcast, we cover:

0:48   Looking into the Gut Deeper

3:53   Good Foundations

6:26   Chewing is Important

8:22   Mushrooms as Anti-Inflammatory Properties

16:00  Probiotics

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Dr. Justin Marchegiani: Hey guys, it’s Dr. Justin Marchegiani here. Today’s podcast is we’re going to be talking about the top five nutrients to address gut inflammation, and leaky gut or gut permeability. So this is a topic that’s pertinent to a lot of our patients as gut inflammation, there’s usually some component in why they’re not feeling good. So I’m really excited to address this today with Evan, we’re gonna dive into the things that we do clinically, the things that work with our patients, the things that actually get results, we’ll break it down, and we’ll kind of give you guys some action items for today as well. And what’s cooking man? How are we doing?

Evan Brand: Hey, you’re doing really well. And you know, we always come up with a title. And then we over deliver on that title. So we’re calling this something along the lines of top five nutrients to help your gut or to heal your gut or support intestinal permeability, but maybe we end up going over five. So I’m just gonna go straight to my favorite because it’s so easy. It’s so broad spectrum in its use. And it’s so safe for people across the board to use it, whether it’s kids, adults, the elderly population, even people that don’t have testing, you know, our philosophy is test don’t guess we want to have the data, we want to have good stool testing, and good organic acids testing to look into the gut deeper and figure out what’s going on under the hood. But there is usually a three, sometimes four week timeline between talking with a client or a new patient and then getting the test results. So what do we do to help these people in that in between time before we can do the real work based on the data, I’d say my favorite is probably aloe, and specifically you and I use an aloe extract. It’s a 200 to one, so it’s 200 pounds of gel converted to one pound of extract, and then that’s encapsulated. We had a young boy, not super young, maybe 16 17. But he was diagnosed with autoimmune gut issues, Crohn’s all sort of colitis, actually pan colitis where the whole digestive tract was affected major bleeding in the store. We got him on simply a 200 to one extract of aloe. And within three weeks, we did a new gi map stool test, and we dropped his calprotectin levels, which is his gut inflammation by 1000 points, just by aloe alone.

Dr. Justin Marchegiani: Unbelievable. Yeah, it’s powerful what nutrients can do now I always tell patients, if you’re trying to come in and make some changes out of the gates, I mean, your best bang for your buck would be fixing the food, because the food is constantly getting your body getting your gut in flames. So the first thing we can do is look at the the the inflammatory food that could be coming in this could be gluten or other technically gluten free grains like corn, oat, rice, those kinds of things. So you want to really get the grains out, you want to really get a lot of the poly polyunsaturated omega six vegetable oils. And again, the reason why vegetable oils tend to be more, let’s say poor is because they’re highly processed to extract the fat. And the processing actually damages the fat and creates free radical stress within those fats. Because the more you take in damaged fats, your body has to utilize antioxidants to stabilize the fats. So they don’t create free radicals. And so it depletes a lot of your antioxidants. And then those fast take on and become part of your cell membrane. And to have healthy cells you have to have good membrane. Because the membrane essentially is the brain of your cell. It provides a lot of good cellular communication happens with the membrane. So if you have junky fats, whether it’s omega six junky fats, or trans fats like hydrogenated soybean oil, right, those kinds of things, canola, you know, safflower, those are going to be more junky omega six, and they’re going to really not make the healthiest cell membranes, they’re going to deplete your antioxidant reserves. And if they’re on the trans fat side, they’ll make your cell membranes very inflexible too.

Evan Brand: Yeah, good point. And I apologize for skipping over the diet piece, you know, you think of the typical American person, they think, just give me the pill. Give me the magic remedy. So we’ll talk about some of those remedies. But yeah, you make a great point, you can’t go out to Pizza Hut for dinner, and then just take an aloe capsule, and everything’s going to be okay. Correct.

Dr. Justin Marchegiani: Yeah. So that’s it’s good to look at the foundation out of the gates. I’d also say like, I’ll just kind of put this next category into a broad category and just say, amino acids. And these amino acids could be things like an acetylglucosamine, NaG that could be things like glycine, which are going to be very high in collagen or bone broth. And they could also be things like glutamine, so I kind of put these in the amino acid bucket, when they tend to be very good support for the entire sites of the gut lining, that can be used as fuel for the gut lining, they also can help with gut permeability. And, and glycine is a really good backbone for connective tissue. So it can be very helpful for that lot of that connective tissue healing out of the gates.

Evan Brand: So how about enzymes? When you hear nutrients to heal the gut or support the gut, you don’t necessarily think about enzymes, you think of more like you mentioned, the glutamine, Aloe, the kind of calming, soothing things, but I would argue enzymes have a role in helping with reducing gut inflammation simply by improving digestion and reducing the putrifying and fermenting of foods because I know my gut was Super inflamed. If I look back at some of my original stool tests, when I had gut infections, yes, I was doing things to soothe my gut, but simply just treated, the infections alone got the inflammation down. And part of that process of treating the infections was using enzymes, because my digestion was so terrible, I would get exhausted after a meal. And that was a sign that I had low stomach acid. So I would say the enzyme should be on our list here, because so many people do to age due to stress. Maybe you’re eating in a loud restaurant, like you’re on your lunch break for work, and you’re listening to us or there’s music, boom, boom, boom in the background, and you’re sympathetically stressed while you’re eating enzymes, to me would be a good insurance policy to help break down your foods and then therefore reduce inflammation.

Dr. Justin Marchegiani: Yeah, foods are not broken down properly, they’re going to sit, they’re going to ferment, they’re going to purify, they’re going to read certify also, those foods are more likely to create hydrogen and methane gases because they’re fermenting, and those gases can throw off your motility, motility and how you move the bowels. And if the bowels are one too short, or should take too fast on the diarrhea side, you may not absorb those nutrients well. And if they’re too long, on the conservation side, you may reabsorb fecal toxins. And so you know, long or short on the bowel motility can definitely affect absorption or create more toxins in the body. So I think that’s a big one. And then just kind of connecting the enzymes and we could throw HCl in there too, because HCl helps activate enzymes, I would say chewing, chewing and and really just the mastication and healthy eating habits because chewing your food up really fine, allows more surface area for those enzymes and acids to work. So you can have a good amount of enzymes or acids, you only have a couple of chews. you swallow your food, those enzymes and acids aren’t gonna work as good as you really chew it up, you know, 30 to choose one chew per tooth, you know, ideally like an oatmeal like consistencies and allow those enzymes and acids to work better.

Evan Brand: Yeah, I’m 18th down. So I guess I get off the hook with 32. You know, I have my wisdom teeth and my 12 year molders out so.

Dr. Justin Marchegiani: Oh, yeah, there you go. I mean, I have my wisdom teeth out as well. So I’m kind of at 28 as well. So I get it. So let’s just say 30 plus or minus a couple.

Evan Brand: It’s hard. I’ve tried to do that I’ve tried to do that many choose, oh man, my jaw gets tired. So and that’s the that’s the problem too, that we have with our food is like you go to Chipotle, a for example. Everything’s really soft. Like if you get rice if you get like carnitas. Or if you get the chicken, you barely have to chew it. It’s almost like mush. So I try to personally seek out occasionally I will seek out whether it’s like beef jerky, or no bison jerky or even just a steak, you know, I try to really get something that works my job because I just feel like in America, our food is so soft and easily digestible, that we don’t have to really chew anymore.

Dr. Justin Marchegiani: Yeah, so if you have a nice steak or a nice whole chicken, just make sure you chew it up. Same thing goes with over hydrating, you know, try to get your first thing I do is and I get to go eat a meal, I kind of go to the reverse osmosis filter, get a nice big glass of water to add some minerals, one, two, and then I get my meal going that way it gives me 10 15 minutes or so for everything to absorb. And of course the colder the water you got to take a little bit longer because your body holds that water in your stomach, heats it up to about room temperature and then passes it through. So the colder that water is, the longer you should wait in between the meal

About mushrooms. This is something that you know, just doing a little bit of research before we hit record, that this is something that I don’t necessarily go to right out of the gate but I’ve been using mushrooms for a long time. I know you and I personally have been taking mushrooms for a long time. And it turns out that for example, Lion’s Mane mushroom has some really, I would say probably just as impressive as some of the other herbs you’re mentioning, whether it’s like dgl, licorice or marshmallow kind of the conventional gut healing ones. Lion’s Mane has some really awesome anti inflammatory properties. There were two papers that we had found here on Lion’s Mane mushroom being shown to protect from and shrink gastric ulcers. Also, Lion’s Mane was shown to significantly improve symptoms of two major inflammatory disorders of the digestive system. And so that’s cool, because normally we’re using Lion’s Mane for cognitive problems. I know for me, my brain is much more clear. I’ve got Lion’s Mane mushroom in my system right now. I took two capsules this morning, and I certainly feel it mentally. But I did not even think that I was feeling it in my gut. So that’s cool.

Totally. Yeah, that gets really important. Again, a lot of gut issues, the immune system can be a big player at it. And so of course, if you’re able to modulate the immune system with the medicinal mushrooms, or immunogenic compounds that are going to be in those mushrooms, whether it’s beta one, three, D glucan, whatever that is, it could have an effect on gut permeability and improving digestion. I think all that’s very, very important. Also, just kind of one pet peeve of mine. Someone in the comments was chatting about this. A lot of people when they talk about leaky gut, they talk about leaky gut like like it’s the cause of Problem. leaky gut is the effects of on what’s happening with the gut. So the more inflamed you are, the more you’re not breaking down your food. The more crappy The food is, the more inflammatory The food is, the more dysbiosis we have, the the lack of certain nutrients we have, the more stress we are right. All that then creates and increases the chance of gut permeability. Gut permeability isn’t the cause unto itself. It’s the effects of a lot of other issues happening. So when people talk about Oh, you gotta fix the leaky gut. It’s like, not necessarily, you know, it’s like, it’s like saying, Oh, we have to fix. Imagine you have a leak in your roof and the waters pulling on the carpet below you. So we got to fix that water on the floor. It’s like, No, no, you fix the hole in the roof. And again, it may be semantics, but we got to call a spade a spade. If the water’s coming into the roof, you talk to them, we got to fix the hole in the roof. You don’t say we fixed the the water on the ground, right? So I just want everyone I want to train everyone to kind of get thinking about things from a root cause standpoint, versus labeling the damage at the end result conventional medicines really good at labeling damage down here and not talking about the effects of top that should the cause up top there labeling the effects down here. So we want to go root cause?

Yeah, that’s great. And I’m sure we could come up with other analogies on it. But that makes a lot of sense. It’s kind of like, okay, we need to come in with the towel. Oh, no. Now we have this super absorbent towel, this towel is going to absorb 1000 times more water on your floor than any other towel. And then yes, this, this carpet is mold resistant. So if you use this carpet, that water in your carpet won’t create mold, but you’re still missing the frickin hole in the roof roof.

Exactly, exactly. So we just got to really be on top of that. Make sure everyone’s thinking root cause I think that’s really helpful.

Well, let’s call it out. Let’s call out why that happens, though. It’s simply money. And it’s the supplement industry. There’s a lot of money. Yeah, it’s marketing. There’s a lot of money made on leaky gut this and this leaky gut book and this leaky gut protocol and this leaky gut practitioner. The problem is you could take all these leaky gut support for a decade and never treat the infections like if you just went and did like you mentioned glutamine, and we hit the zinc carnosine and the dgl. And we did the aloe, like we talked about in the beginning, none of those are going to erase a blastocyst is hominis, parasite infection, none of those are going to get rid of Giardia. None of those are going to treat the H pylori, they may help. But they’re definitely not going to eradicate the issue causing the leaky gut in the first place. So that’s just marketing. It’s money involved in this. And, you know, as practitioners, I think it’s really smart of you to call it out like that, because it’s, it is frustrating for us because we’ll look on a new client or new patients intake form. And they’ll be taking all these quote leaky gut supplements. Yeah, I found this leaky gut protocol online, and I still have all these digestive problems. And it’s like, well, yeah, look at your stool test, you have all these issues. And you could do that for 20 years and never fix it. So I could rant on that all day.

Yeah, other thing I would just say out of the gates is it’s okay to palliative Li support the leaky gut, we just have to make sure when you’re palliative Li supporting something we’re also root cause supporting it as well root cause fixing it. Palliative support, totally fine, right. Nothing wrong with that we just got to call a spade a spade and and not pretend the palliative leaky gut support is root cause support. Yeah, long as we can do that, then I think we’re pretty good. Next thing I would highlight out of the gates and you see this herb being listed as being very helpful for the gut permeability, but it’s also very helpful on the adrenal. So that’s licorice. And so when we use licorice is a lot of licorice being used in leaky gut supports. That’s that’s d glycerides. And this is the glycerides component of the licorice is pulled out. And the glycerides component of a licorice is is the component that slows the breakdown of cortisol, I think it’s the 11 beta hydroxy steroid dehydrogenase to enzyme. The licorice inhibits that enzyme. That’s the enzyme that helps break down cortisol. So we know cortisol too low, we need healthy levels of cortisol to actually build up the gut lining. It helps with building up the gut lining. Of course, if our cortisol levels are too high, and we’re chronically stressed, right, that can also break down the gut lining. We know that with people that are chronically stressed getting ulcers, right, we know that as well. And so when we look at licorice, it really helps with cortisol improvement. So if we do a cortisol test, and we see chronically low cortisol, that can actually help with the gut lining with the mucosa with the stomach with the duodenum. And that can actually help with the cortisol bringing that back up. And that can help build back up that gut lining. And so we like licorice, that’s non diglycerides for the gut and Nanda glycerides licorice, we give it typically orally sublingually, to our patients, that will eventually trickle downstream to the gut as well. And so licorice can be a powerful thing. You just have to be careful if you’re giving a non diglycerides version that people that have already higher level of cortisol, that may make things worse. So we just got to make sure we’re testing that to know what kind of pattern we’re seeing.

Yeah, that’s a good point. So we could do a whole part two on that. If you want. Give us some feedback. Like maybe the gut hormone connection. And we could hit that in detail. But yeah, you highlighted a very important point, which is that cortisol is involved with this whole process. And it really is a Goldilocks zone. If you have too little cortisol, you’re exhausted. And you’re probably going to be dependent on stimulants and caffeine and sugar and things that are going to damage your gut. But then simply, you don’t have enough to build up the gut. And then if you have too much, now you’re catabolic, you’re breaking down your muscle tissue, and you’re breaking down your gut barrier. That’s probably part of the reason that I lost a lot of weight and a lot of muscle. When I first moved to Texas, I had gut infections, and I was incredibly stressed, just moving and leaving my family behind, you know, emotional stuff, homesickness gut infections, I had the perfect storm to tear up my gut. So I can tell you firsthand that adrenal supports did help. And that was probably because it was helping regulate the cortisol levels, which then in turn, took the load off my gut, so to speak.

100% Yeah, I like that. And so it’s good to really make sure that’s under control. 

Evan Brand: How about probiotics? I think it’s worth mentioning. These are totally valuable tools that can help regulate histamine. Yeah, and regulate bacteria with it. So let’s dive into that.

Dr. Justin Marchegiani: Yeah, so you have to you I said you have three to four big families. Okay. So you typically have your lactobacillus and bifidobacterium, which are typically come together and usually a good high quality broad spectrum probiotic. So my line we have one called profile, Florida doesn’t have a lot of the different lactobacillus whether it’s kci acidophilus Bulgaria’s brevis, rhamnosus. And then of course, you have a lot of the bifidobacterium whether it’s bifidobacterium, bifidum, longum, brevis, right. So those are your broad spectrum lactobacillus or bifidobacterium. Probiotics, lots of good data, lots of good research anywhere from food poisoning for inflammation reduction, gut permeability reduction. nutrient absorption is all kinds of different studies connecting the dots on those so that’s kind of the bifidobacteria, lactobacillus Of course, we have more of our spore based or soil based probiotics. These are going to be a lot of your bacillus strains, right, whether it’s bacillus, subtlest class ei coagulans, like Informix, right. These are the bacillus strains. These are really good if you are very much cebo sensitive, fodmap sensitive, we may use some of these over a bifido lactobacillus species. And then of course, I’m a big fan of the probiotic that’s kind of more of a beneficial yeast called Saccharomyces boulardii in my lammie, one called sacral flora, again, we’ll put the links below for for all y’all so if you want to see it, we’ll put the links below sacral Flora Saccharomyces boulardii is very helpful a lot of studies on it, helping to improve immunity in the gut IGA IGA levels going to get low and just gut inflammation or gut stress. Of course, it’s going to help with food poisoning a lot of studies on it helping with H. pylori, C. diff, Clostridium difficile, blastocystis hominess. It also helps crowd out yeast and Candida so there’s a lot of excellent benefits with saccharomyces we love it and it’s usually going to be a core part of my probiotic, my fifth r which is repopulation re inoculation on the good healthy probiotics, once the fourth hour is done right fourth hours and to be removing the gut bugs removing the gut infections. Fifth hour, we come in repopulate re inoculate with good bacteria. Most people kind of sweet they want to start probiotics sooner, and that may not be the best step. Not saying it may not help. But some people have just found one that’s just a lot of pills. And two, if they have a lot of bad bugs in there. It’s like going and getting a whole bunch of good fresh grass seeds throw down on a lawn full of weeds, right? You got to get the weeds done before we throw down the seeds right got to get the car washed or we get waxed.

Evan Brand: Kind of like that. Yeah, we had a lot of good feedback on the podcast we did remember we were talking about probiotics and how a lot of new research is showing probiotics are being used to help with getting out mycotoxins and we know that mold toxins damage the gut. So yes, so I have been I’ve honestly been working in probiotics into the protocol sooner and most people do well. There are some like you said that just don’t you got to pull the weeds before you throw the seeds. But there are a lot of people doing really good with throwing probiotics and sooner in the protocols now. So like you said, if they can handle the amount of pills, maybe we try to sneak one or two in or we could do like powdered versions, typically, it’s like a quarter teaspoon, we could throw in a blend like that sack be you could you could do powder and maybe throw it in a smoothie or something. So we are trying to integrate those a lot. And I’ve had amazing success personally with probiotics. So I think it’s interesting, there’s still a lot of people that poopoo probiotic probiotics I know you and I we kind of get, you know, so caught up in the clinical trenches that we may miss some things, but I do get a couple of emails, you know, here and there from from people, clients sending them like, hey, this guy like says probiotics are a waste of money, and you know, that they don’t work. And I would just say that’s not true. We have so much clinical data personally.

Dr. Justin Marchegiani: It’s all about context, right? It’s like if someone comes in, they have chronic gut issues, and they’re just taking a probiotic thinking that that’s going to be the answer to their gut problems. It’s probably not right, and that’s where we’re trying to have a comprehensive functional medicine plan. That’s root cause and not just trying to Pro supplements at the wall thinking that that’s going to fix it. So yeah, I understand if that you know where that person is coming up with that, that bias that biases from not having a comprehensive root cause plan with a functional medicine practitioner, they’re just trying to throw stuff at them instead it hoping it will fix the symptoms, not fix the root cause.

Well, here’s Yeah, good, good point. Here’s the other thing, too, it’s even some probiotic companies will say that about other companies, it’s more of a marketing thing like, hey, their probiotic is crap, or it doesn’t work because of X, Y, or Z. But I will just say with what you and I use, clinically, we’re using professional supplement manufacturers exclusive only to health care providers. And a lot of the stuff we use, we have extended release technology. So when arguments like probiotics are going to die in the stomach, they’re not even going to make it to where they need to. But a lot of the new technology we use, they’re not even going to break open, they’re going to be resistant to the stomach acid. So that’s another problem too, when you hear these little like, super sometimes buzzworthy type articles. It’s not taking into consideration the quality, the quantity, the purity, the potency, the technology involved, it’s like probiotics, they get the label, and then that’s it. And that’s just not a fair classification.

Correct. And then also consumer reports that a study on probiotics a couple years back maybe 5 10 years ago. And what they found is most probiotics that they put a number on the outside of the bottle, hey, this is how many colony forming units. And what a lot of the cheap companies do is they say, Okay, this is how many should have been in this probiotic at manufacturing of this product. Let’s say it’s 20 billion. Now, what the professional companies do is, right, when you’re buying high quality, professional ingredients, they’re gonna say this is how many colony forming units should be in this capsule at expiration. And so you’re looking at something like two to three times the amount of those that species that CFU on the bottle colony forming units, is going to be typically in there. So when you see like, in my probiotic, I think it’s 40 billion per two capsules, right? That’s going to be what’s in there two years from now at expiration, right? And so obviously, it’s going to be two to three times the amount of that before. And so you want to use professional companies. So what you see on the label is always worst case, scenario, number one, and then also how products are stored by professional companies is very important. So like, where we have our warehouses, like everything is stored in an air conditioned or a refrigerated environment for a lot of our probiotics, some don’t necessarily need that. But which we value, the the scenario and how that store because that really increases potency, too.

Evan Brand: Yeah. And the funny thing is, too, we’ve seen some papers on supposedly expiration dates, you know, this is something that you and I are forced to do with the professional companies we work with. But you know, we’ve seen some research on supplements from 2030 years ago, still being viable, meaning they still had some potency and purity to them. And obviously, they still had a biological effect. So to me, I would if I had to pick like a consumer shelf bought probiotic, or a suppose that expired professional product, I’m going to go for the supposedly expired product, I’d go for a five year old professional probiotic, then, you know, on the shelf today consumer level.

Dr. Justin Marchegiani: Yeah, exactly. And also a lot of the probiotics or supplements that require refrigeration on the warehousing side, a lot of times you’re just not going to get that on Amazon, you’re not going to get that level of specificity just because that’s not how their warehouses are set up. And so with ours, we make sure that that refrigeration components is there because we’re working with patients and we need we need that potency, because we’re trying to get clinical outcomes, right. We’re trying to sell and provide a clinical outcome for the patient. And if we’re just providing products that aren’t meeting that standard, we’re not going to win. And of course, we want to be successful on that front.

Evan Brand: Yeah, yeah. Well say Well, I think we covered a lot of it. So the mushrooms are beneficial Lion’s Mane the mushroom is amazing for the brain, but for the gut also Chaga mushroom would be great reishi mushroom could also deserve a good mention, you hit upon the amino acids. So the glutamine or the various types of glucose amines involved. We love amino acids, we use those all the time you mentioned like collagen also being you know, part of that makeup, we hit on some of the herbs like the the licorice, or the dgl version of it, the marshmallow, we like to use a lot, we hit upon the aloe, and then we hit the probiotics, I think those are the big categories. And then the enzymes we hit that too.

Dr. Justin Marchegiani: I think we did a really good job hitting a couple and I just I really want to plug in concepts, right? Like a lot of people, they just try to throw information at people and and try to memorize that. I think that’s not beneficial. But if you can just understand concepts, right? A concept is just something that sticks. You either get it or you don’t. And so we try to use a lot of analogies and understand we try to plug in a lot of the concepts of root cause versus palliative cause. We try to get you to think about, hey, if this helps, why does it help? is it just an anti inflammatory? is it helping just improve better digestion? is it helping your immune system? is it helping your adrenals and helping you that your body’s natural process to build back up that gut lining? What’s the underlying mechanisms if you understand that, then you see how it plugs into the greater matrix of healing.

Evan Brand: Yeah, I mean, I agree 1,000%. So, I think the big concept of today is Yes, here are some things here are some nutrients you can use. However, we really want to make sure you’re testing, not guessing. So if you do need the aloe to calm the gut for now, you need the enzymes to help improve digestion. For now, you notice that HCl is helping with your heartburn or you notice that the enzymes are reducing your bloating, or your burping or your gas. Great, but what led to all that in the first place? What led you to need the aloe because you had gut inflammation, what led you to need the enzymes, that’s where somebody like us can come in and help you figure that out and plot it on paper. And, you know, we’ve been through the trenches personally. And clinically, we’re always improving upon herself. You know, I work on my children, I know you work on your children, we’re giving our kids things to help their guts, I mean, so this is like a, there’s no finish line, I don’t want people to think, Hey, I just do this aloe for a month, and then I’m done. You know, there’s not a finish line with the gut, we’re constantly being exposed to new toxins and new pathogens. We’ve even seen with the virus that’s been going around a lot of issues with the gut there, we’ve seen a lot of issue with tissue destruction in the intestinal tract. So who knows? Right now with the 5 10 year outlook of the GI health in the US is right now, our guts are notoriously bad, due to glyphosate and other things, damaging them. So just a quick note, you kind of started with the diet all and with the diet 100% organic is important, if you’re going to go buy all these probiotics, but yet, you’re going to eat strawberries with an average of 22 pesticides on them. If they’re not organic, you’re wasting your frickin time and your money because we know all those pesticides are just killing the beneficial bacteria in your gut that you’re trying to re inoculate or repopulate with. So please go organic, you know, before you spend money on probiotics.

Dr. Justin Marchegiani: Exactly. And then also how long do these probiotic strains last in your gut, I mean, a lot of times, you’re going to see the data show in about one month or so. So that they don’t stay forever. So when you take a probiotic, it’s not like it’s there forever. So it’ll it’ll hang around typically for a month, it’ll help with a nutrient synthesis, it’ll help with nutrient absorption, it’ll help with inflammation, modulating the immune system, there’s some data that maybe the spore based probiotics hang around a little bit longer, and they may help proliferate the growth of other beneficial species. So just think when you take a probiotic, it’s not forever. Now the goal is that we’re getting some level of fermentable foods in your diet, whether it’s from sauerkraut, or low sugar kombucha, or some kind of fermented pickle or something, or, you know, cultured coconut milk or potentially high quality raw milk if you can tolerate it. So you know, that’s typically how we’re getting exposed to probiotics more on a day in weekend kind of situation. If you’re someone that can’t get that level of exposure with fermented oils from food, then you probably want to be on a probiotic a little bit more frequently, if you’re not getting those fermentable. So we just got to plug and play where we’re at. I think our ancestors probably did more fermentable foods, which is ideal. But if we can’t we plug in a good quality probiotic, or at least throw in something every couple of months, just to kind of fill in the gap to make sure we’re getting exposed to those good for mandibles.

Evan Brand: Yeah, great point, I just want to highlight what you said too, which is like your gut bacteria are actually going to help you with your health in other ways. So once gut bacteria optimize your healing the gut, you’re making neurotransmitters the way you should you’re making serotonin, you’re making things to improve yourself, you’re making B vitamins to help your energy and your mitochondria. So this is why I really the gut, I mean, we just we can’t stop talking about it because it literally is the foundation.

Dr. Justin Marchegiani: Exactly. So just kind of want to make sure that is understood. And that makes sense for everyone. We’ll put a list of recommended products down below. So you guys have access to those you want to support us support the show, we appreciate it put those down below. Also, if you guys want to reach out to Evan brand, head over to EvanBrand.com, Evan is there for you guys worldwide. And again, I’m there for you as well, justinhealth.com, Dr. J myself, there’ll be a little link button, you guys can click and reach out to us we are available worldwide to help you guys help you help support y’all. We want to make sure they have the support you need. And you have a good comprehensive plan to get what’s going in the right direction if you’re not having success. And then also just try to apply one thing today as well. If you’re having if you’re overwhelmed, and you’re having a sticking point great to reach out, if not just try applying this information, we want to really help as many people as possible. And we know we’re going to help many more people than we actually see in person with this information. So just make sure you’re applying it. And if you are enjoying it, share it with family and friends that could also benefit put your comments down below. Let me know the best part that you liked about this what resonate with you the most. And give us a like and share as well. We appreciate it.

Evan Brand: Yeah, and if you’re on the apple listening, if you’re on your Apple podcast app or Stitcher or wherever else, give us some stars, let us know what you think the show deserves between us both we have I lost count, but it was somewhere over 705 star reviews for our podcast in between our various feeds. So please give us some stars. Give us some sentences give us a blurb on whether you still call it iTunes or Apple podcast. We’d love to beat out people that are not clinically oriented. There’s still like top health podcast out there that it’s just theory theory theory theory. And then we have to like recalibrate people’s theories because they’re not clinically based. So we would love to beat those people. How do we beat those Before we go higher in the charts, how do we do that? With your reviews! So we have a some stars. 

Dr. Justin Marchegiani: Thanks to all you guys have a phenomenal day. Take careDr. Justin Marchegiani  

Hey guys, it’s Dr. Justin Marchegiani here. Today’s podcast is we’re going to be talking about the top five nutrients to address gut inflammation, and leaky gut or gut permeability. So this is a topic that’s pertinent to a lot of our patients as gut inflammation, there’s usually some component in why they’re not feeling good. So I’m really excited to address this today with Evan, we’re gonna dive into the things that we do clinically, the things that work with our patients, the things that actually get results, we’ll break it down, and we’ll kind of give you guys some action items for today as well. And what’s cooking man? How are we doing?

Evan Brand: Hey, you’re doing really well. And you know, we always come up with a title. And then we over deliver on that title. So we’re calling this something along the lines of top five nutrients to help your gut or to heal your gut or support intestinal permeability, but maybe we end up going over five. So I’m just gonna go straight to my favorite because it’s so easy. It’s so broad spectrum in its use. And it’s so safe for people across the board to use it, whether it’s kids, adults, the elderly population, even people that don’t have testing, you know, our philosophy is test don’t guess we want to have the data, we want to have good stool testing, and good organic acids testing to look into the gut deeper and figure out what’s going on under the hood. But there is usually a three, sometimes four week timeline between talking with a client or a new patient and then getting the test results. So what do we do to help these people in that in between time before we can do the real work based on the data, I’d say my favorite is probably aloe, and specifically you and I use an aloe extract. It’s a 200 to one, so it’s 200 pounds of gel converted to one pound of extract, and then that’s encapsulated. We had a young boy, not super young, maybe 16 17. But he was diagnosed with autoimmune gut issues, Crohn’s all sort of colitis, actually pan colitis where the whole digestive tract was affected major bleeding in the store. We got him on simply a 200 to one extract of aloe. And within three weeks, we did a new gi map stool test, and we dropped his calprotectin levels, which is his gut inflammation by 1000 points, just by aloe alone.

Dr. Justin Marchegiani: Unbelievable. Yeah, it’s powerful what nutrients can do now I always tell patients, if you’re trying to come in and make some changes out of the gates, I mean, your best bang for your buck would be fixing the food, because the food is constantly getting your body getting your gut in flames. So the first thing we can do is look at the the the inflammatory food that could be coming in this could be gluten or other technically gluten free grains like corn, oat, rice, those kinds of things. So you want to really get the grains out, you want to really get a lot of the poly polyunsaturated omega six vegetable oils. And again, the reason why vegetable oils tend to be more, let’s say poor is because they’re highly processed to extract the fat. And the processing actually damages the fat and creates free radical stress within those fats. Because the more you take in damaged fats, your body has to utilize antioxidants to stabilize the fats. So they don’t create free radicals. And so it depletes a lot of your antioxidants. And then those fast take on and become part of your cell membrane. And to have healthy cells you have to have good membrane. Because the membrane essentially is the brain of your cell. It provides a lot of good cellular communication happens with the membrane. So if you have junky fats, whether it’s omega six junky fats, or trans fats like hydrogenated soybean oil, right, those kinds of things, canola, you know, safflower, those are going to be more junky omega six, and they’re going to really not make the healthiest cell membranes, they’re going to deplete your antioxidant reserves. And if they’re on the trans fat side, they’ll make your cell membranes very inflexible too.

Evan Brand: Yeah, good point. And I apologize for skipping over the diet piece, you know, you think of the typical American person, they think, just give me the pill. Give me the magic remedy. So we’ll talk about some of those remedies. But yeah, you make a great point, you can’t go out to Pizza Hut for dinner, and then just take an aloe capsule, and everything’s going to be okay. Correct.

Dr. Justin Marchegiani: Yeah. So that’s it’s good to look at the foundation out of the gates. I’d also say like, I’ll just kind of put this next category into a broad category and just say, amino acids. And these amino acids could be things like an acetylglucosamine, NaG that could be things like glycine, which are going to be very high in collagen or bone broth. And they could also be things like glutamine, so I kind of put these in the amino acid bucket, when they tend to be very good support for the entire sites of the gut lining, that can be used as fuel for the gut lining, they also can help with gut permeability. And, and glycine is a really good backbone for connective tissue. So it can be very helpful for that lot of that connective tissue healing out of the gates.

Evan Brand: So how about enzymes? When you hear nutrients to heal the gut or support the gut, you don’t necessarily think about enzymes, you think of more like you mentioned, the glutamine, Aloe, the kind of calming, soothing things, but I would argue enzymes have a role in helping with reducing gut inflammation simply by improving digestion and reducing the putrifying and fermenting of foods because I know my gut was Super inflamed. If I look back at some of my original stool tests, when I had gut infections, yes, I was doing things to soothe my gut, but simply just treated, the infections alone got the inflammation down. And part of that process of treating the infections was using enzymes, because my digestion was so terrible, I would get exhausted after a meal. And that was a sign that I had low stomach acid. So I would say the enzyme should be on our list here, because so many people do to age due to stress. Maybe you’re eating in a loud restaurant, like you’re on your lunch break for work, and you’re listening to us or there’s music, boom, boom, boom in the background, and you’re sympathetically stressed while you’re eating enzymes, to me would be a good insurance policy to help break down your foods and then therefore reduce inflammation.

Dr. Justin Marchegiani: Yeah, foods are not broken down properly, they’re going to sit, they’re going to ferment, they’re going to purify, they’re going to read certify also, those foods are more likely to create hydrogen and methane gases because they’re fermenting, and those gases can throw off your motility, motility and how you move the bowels. And if the bowels are one too short, or should take too fast on the diarrhea side, you may not absorb those nutrients well. And if they’re too long, on the conservation side, you may reabsorb fecal toxins. And so you know, long or short on the bowel motility can definitely affect absorption or create more toxins in the body. So I think that’s a big one. And then just kind of connecting the enzymes and we could throw HCl in there too, because HCl helps activate enzymes, I would say chewing, chewing and and really just the mastication and healthy eating habits because chewing your food up really fine, allows more surface area for those enzymes and acids to work. So you can have a good amount of enzymes or acids, you only have a couple of chews. you swallow your food, those enzymes and acids aren’t gonna work as good as you really chew it up, you know, 30 to choose one chew per tooth, you know, ideally like an oatmeal like consistencies and allow those enzymes and acids to work better.

Evan Brand: Yeah, I’m 18th down. So I guess I get off the hook with 32. You know, I have my wisdom teeth and my 12 year molders out so.

Dr. Justin Marchegiani: Oh, yeah, there you go. I mean, I have my wisdom teeth out as well. So I’m kind of at 28 as well. So I get it. So let’s just say 30 plus or minus a couple.

Evan Brand: It’s hard. I’ve tried to do that I’ve tried to do that many choose, oh man, my jaw gets tired. So and that’s the that’s the problem too, that we have with our food is like you go to Chipotle, a for example. Everything’s really soft. Like if you get rice if you get like carnitas. Or if you get the chicken, you barely have to chew it. It’s almost like mush. So I try to personally seek out occasionally I will seek out whether it’s like beef jerky, or no bison jerky or even just a steak, you know, I try to really get something that works my job because I just feel like in America, our food is so soft and easily digestible, that we don’t have to really chew anymore.

Dr. Justin Marchegiani: Yeah, so if you have a nice steak or a nice whole chicken, just make sure you chew it up. Same thing goes with over hydrating, you know, try to get your first thing I do is and I get to go eat a meal, I kind of go to the reverse osmosis filter, get a nice big glass of water to add some minerals, one, two, and then I get my meal going that way it gives me 10 15 minutes or so for everything to absorb. And of course the colder the water you got to take a little bit longer because your body holds that water in your stomach, heats it up to about room temperature and then passes it through. So the colder that water is, the longer you should wait in between the meal

About mushrooms. This is something that you know, just doing a little bit of research before we hit record, that this is something that I don’t necessarily go to right out of the gate but I’ve been using mushrooms for a long time. I know you and I personally have been taking mushrooms for a long time. And it turns out that for example, Lion’s Mane mushroom has some really, I would say probably just as impressive as some of the other herbs you’re mentioning, whether it’s like dgl, licorice or marshmallow kind of the conventional gut healing ones. Lion’s Mane has some really awesome anti inflammatory properties. There were two papers that we had found here on Lion’s Mane mushroom being shown to protect from and shrink gastric ulcers. Also, Lion’s Mane was shown to significantly improve symptoms of two major inflammatory disorders of the digestive system. And so that’s cool, because normally we’re using Lion’s Mane for cognitive problems. I know for me, my brain is much more clear. I’ve got Lion’s Mane mushroom in my system right now. I took two capsules this morning, and I certainly feel it mentally. But I did not even think that I was feeling it in my gut. So that’s cool.

Totally. Yeah, that gets really important. Again, a lot of gut issues, the immune system can be a big player at it. And so of course, if you’re able to modulate the immune system with the medicinal mushrooms, or immunogenic compounds that are going to be in those mushrooms, whether it’s beta one, three, D glucan, whatever that is, it could have an effect on gut permeability and improving digestion. I think all that’s very, very important. Also, just kind of one pet peeve of mine. Someone in the comments was chatting about this. A lot of people when they talk about leaky gut, they talk about leaky gut like like it’s the cause of Problem. leaky gut is the effects of on what’s happening with the gut. So the more inflamed you are, the more you’re not breaking down your food. The more crappy The food is, the more inflammatory The food is, the more dysbiosis we have, the the lack of certain nutrients we have, the more stress we are right. All that then creates and increases the chance of gut permeability. Gut permeability isn’t the cause unto itself. It’s the effects of a lot of other issues happening. So when people talk about Oh, you gotta fix the leaky gut. It’s like, not necessarily, you know, it’s like, it’s like saying, Oh, we have to fix. Imagine you have a leak in your roof and the waters pulling on the carpet below you. So we got to fix that water on the floor. It’s like, No, no, you fix the hole in the roof. And again, it may be semantics, but we got to call a spade a spade. If the water’s coming into the roof, you talk to them, we got to fix the hole in the roof. You don’t say we fixed the the water on the ground, right? So I just want everyone I want to train everyone to kind of get thinking about things from a root cause standpoint, versus labeling the damage at the end result conventional medicines really good at labeling damage down here and not talking about the effects of top that should the cause up top there labeling the effects down here. So we want to go root cause?

Yeah, that’s great. And I’m sure we could come up with other analogies on it. But that makes a lot of sense. It’s kind of like, okay, we need to come in with the towel. Oh, no. Now we have this super absorbent towel, this towel is going to absorb 1000 times more water on your floor than any other towel. And then yes, this, this carpet is mold resistant. So if you use this carpet, that water in your carpet won’t create mold, but you’re still missing the frickin hole in the roof roof.

Exactly, exactly. So we just got to really be on top of that. Make sure everyone’s thinking root cause I think that’s really helpful.

Well, let’s call it out. Let’s call out why that happens, though. It’s simply money. And it’s the supplement industry. There’s a lot of money. Yeah, it’s marketing. There’s a lot of money made on leaky gut this and this leaky gut book and this leaky gut protocol and this leaky gut practitioner. The problem is you could take all these leaky gut support for a decade and never treat the infections like if you just went and did like you mentioned glutamine, and we hit the zinc carnosine and the dgl. And we did the aloe, like we talked about in the beginning, none of those are going to erase a blastocyst is hominis, parasite infection, none of those are going to get rid of Giardia. None of those are going to treat the H pylori, they may help. But they’re definitely not going to eradicate the issue causing the leaky gut in the first place. So that’s just marketing. It’s money involved in this. And, you know, as practitioners, I think it’s really smart of you to call it out like that, because it’s, it is frustrating for us because we’ll look on a new client or new patients intake form. And they’ll be taking all these quote leaky gut supplements. Yeah, I found this leaky gut protocol online, and I still have all these digestive problems. And it’s like, well, yeah, look at your stool test, you have all these issues. And you could do that for 20 years and never fix it. So I could rant on that all day.

Yeah, other thing I would just say out of the gates is it’s okay to palliative Li support the leaky gut, we just have to make sure when you’re palliative Li supporting something we’re also root cause supporting it as well root cause fixing it. Palliative support, totally fine, right. Nothing wrong with that we just got to call a spade a spade and and not pretend the palliative leaky gut support is root cause support. Yeah, long as we can do that, then I think we’re pretty good. Next thing I would highlight out of the gates and you see this herb being listed as being very helpful for the gut permeability, but it’s also very helpful on the adrenal. So that’s licorice. And so when we use licorice is a lot of licorice being used in leaky gut supports. That’s that’s d glycerides. And this is the glycerides component of the licorice is pulled out. And the glycerides component of a licorice is is the component that slows the breakdown of cortisol, I think it’s the 11 beta hydroxy steroid dehydrogenase to enzyme. The licorice inhibits that enzyme. That’s the enzyme that helps break down cortisol. So we know cortisol too low, we need healthy levels of cortisol to actually build up the gut lining. It helps with building up the gut lining. Of course, if our cortisol levels are too high, and we’re chronically stressed, right, that can also break down the gut lining. We know that with people that are chronically stressed getting ulcers, right, we know that as well. And so when we look at licorice, it really helps with cortisol improvement. So if we do a cortisol test, and we see chronically low cortisol, that can actually help with the gut lining with the mucosa with the stomach with the duodenum. And that can actually help with the cortisol bringing that back up. And that can help build back up that gut lining. And so we like licorice, that’s non diglycerides for the gut and Nanda glycerides licorice, we give it typically orally sublingually, to our patients, that will eventually trickle downstream to the gut as well. And so licorice can be a powerful thing. You just have to be careful if you’re giving a non diglycerides version that people that have already higher level of cortisol, that may make things worse. So we just got to make sure we’re testing that to know what kind of pattern we’re seeing.

Yeah, that’s a good point. So we could do a whole part two on that. If you want. Give us some feedback. Like maybe the gut hormone connection. And we could hit that in detail. But yeah, you highlighted a very important point, which is that cortisol is involved with this whole process. And it really is a Goldilocks zone. If you have too little cortisol, you’re exhausted. And you’re probably going to be dependent on stimulants and caffeine and sugar and things that are going to damage your gut. But then simply, you don’t have enough to build up the gut. And then if you have too much, now you’re catabolic, you’re breaking down your muscle tissue, and you’re breaking down your gut barrier. That’s probably part of the reason that I lost a lot of weight and a lot of muscle. When I first moved to Texas, I had gut infections, and I was incredibly stressed, just moving and leaving my family behind, you know, emotional stuff, homesickness gut infections, I had the perfect storm to tear up my gut. So I can tell you firsthand that adrenal supports did help. And that was probably because it was helping regulate the cortisol levels, which then in turn, took the load off my gut, so to speak.

100% Yeah, I like that. And so it’s good to really make sure that’s under control. 

Evan Brand: How about probiotics? I think it’s worth mentioning. These are totally valuable tools that can help regulate histamine. Yeah, and regulate bacteria with it. So let’s dive into that.

Dr. Justin Marchegiani: Yeah, so you have to you I said you have three to four big families. Okay. So you typically have your lactobacillus and bifidobacterium, which are typically come together and usually a good high quality broad spectrum probiotic. So my line we have one called profile, Florida doesn’t have a lot of the different lactobacillus whether it’s kci acidophilus Bulgaria’s brevis, rhamnosus. And then of course, you have a lot of the bifidobacterium whether it’s bifidobacterium, bifidum, longum, brevis, right. So those are your broad spectrum lactobacillus or bifidobacterium. Probiotics, lots of good data, lots of good research anywhere from food poisoning for inflammation reduction, gut permeability reduction. nutrient absorption is all kinds of different studies connecting the dots on those so that’s kind of the bifidobacteria, lactobacillus Of course, we have more of our spore based or soil based probiotics. These are going to be a lot of your bacillus strains, right, whether it’s bacillus, subtlest class ei coagulans, like Informix, right. These are the bacillus strains. These are really good if you are very much cebo sensitive, fodmap sensitive, we may use some of these over a bifido lactobacillus species. And then of course, I’m a big fan of the probiotic that’s kind of more of a beneficial yeast called Saccharomyces boulardii in my lammie, one called sacral flora, again, we’ll put the links below for for all y’all so if you want to see it, we’ll put the links below sacral Flora Saccharomyces boulardii is very helpful a lot of studies on it, helping to improve immunity in the gut IGA IGA levels going to get low and just gut inflammation or gut stress. Of course, it’s going to help with food poisoning a lot of studies on it helping with H. pylori, C. diff, Clostridium difficile, blastocystis hominess. It also helps crowd out yeast and Candida so there’s a lot of excellent benefits with saccharomyces we love it and it’s usually going to be a core part of my probiotic, my fifth r which is repopulation re inoculation on the good healthy probiotics, once the fourth hour is done right fourth hours and to be removing the gut bugs removing the gut infections. Fifth hour, we come in repopulate re inoculate with good bacteria. Most people kind of sweet they want to start probiotics sooner, and that may not be the best step. Not saying it may not help. But some people have just found one that’s just a lot of pills. And two, if they have a lot of bad bugs in there. It’s like going and getting a whole bunch of good fresh grass seeds throw down on a lawn full of weeds, right? You got to get the weeds done before we throw down the seeds right got to get the car washed or we get waxed.

Evan Brand: Kind of like that. Yeah, we had a lot of good feedback on the podcast we did remember we were talking about probiotics and how a lot of new research is showing probiotics are being used to help with getting out mycotoxins and we know that mold toxins damage the gut. So yes, so I have been I’ve honestly been working in probiotics into the protocol sooner and most people do well. There are some like you said that just don’t you got to pull the weeds before you throw the seeds. But there are a lot of people doing really good with throwing probiotics and sooner in the protocols now. So like you said, if they can handle the amount of pills, maybe we try to sneak one or two in or we could do like powdered versions, typically, it’s like a quarter teaspoon, we could throw in a blend like that sack be you could you could do powder and maybe throw it in a smoothie or something. So we are trying to integrate those a lot. And I’ve had amazing success personally with probiotics. So I think it’s interesting, there’s still a lot of people that poopoo probiotic probiotics I know you and I we kind of get, you know, so caught up in the clinical trenches that we may miss some things, but I do get a couple of emails, you know, here and there from from people, clients sending them like, hey, this guy like says probiotics are a waste of money, and you know, that they don’t work. And I would just say that’s not true. We have so much clinical data personally.

Dr. Justin Marchegiani: It’s all about context, right? It’s like if someone comes in, they have chronic gut issues, and they’re just taking a probiotic thinking that that’s going to be the answer to their gut problems. It’s probably not right, and that’s where we’re trying to have a comprehensive functional medicine plan. That’s root cause and not just trying to Pro supplements at the wall thinking that that’s going to fix it. So yeah, I understand if that you know where that person is coming up with that, that bias that biases from not having a comprehensive root cause plan with a functional medicine practitioner, they’re just trying to throw stuff at them instead it hoping it will fix the symptoms, not fix the root cause.

Well, here’s Yeah, good, good point. Here’s the other thing, too, it’s even some probiotic companies will say that about other companies, it’s more of a marketing thing like, hey, their probiotic is crap, or it doesn’t work because of X, Y, or Z. But I will just say with what you and I use, clinically, we’re using professional supplement manufacturers exclusive only to health care providers. And a lot of the stuff we use, we have extended release technology. So when arguments like probiotics are going to die in the stomach, they’re not even going to make it to where they need to. But a lot of the new technology we use, they’re not even going to break open, they’re going to be resistant to the stomach acid. So that’s another problem too, when you hear these little like, super sometimes buzzworthy type articles. It’s not taking into consideration the quality, the quantity, the purity, the potency, the technology involved, it’s like probiotics, they get the label, and then that’s it. And that’s just not a fair classification.

Correct. And then also consumer reports that a study on probiotics a couple years back maybe 5 10 years ago. And what they found is most probiotics that they put a number on the outside of the bottle, hey, this is how many colony forming units. And what a lot of the cheap companies do is they say, Okay, this is how many should have been in this probiotic at manufacturing of this product. Let’s say it’s 20 billion. Now, what the professional companies do is, right, when you’re buying high quality, professional ingredients, they’re gonna say this is how many colony forming units should be in this capsule at expiration. And so you’re looking at something like two to three times the amount of those that species that CFU on the bottle colony forming units, is going to be typically in there. So when you see like, in my probiotic, I think it’s 40 billion per two capsules, right? That’s going to be what’s in there two years from now at expiration, right? And so obviously, it’s going to be two to three times the amount of that before. And so you want to use professional companies. So what you see on the label is always worst case, scenario, number one, and then also how products are stored by professional companies is very important. So like, where we have our warehouses, like everything is stored in an air conditioned or a refrigerated environment for a lot of our probiotics, some don’t necessarily need that. But which we value, the the scenario and how that store because that really increases potency, too.

Evan Brand: Yeah. And the funny thing is, too, we’ve seen some papers on supposedly expiration dates, you know, this is something that you and I are forced to do with the professional companies we work with. But you know, we’ve seen some research on supplements from 2030 years ago, still being viable, meaning they still had some potency and purity to them. And obviously, they still had a biological effect. So to me, I would if I had to pick like a consumer shelf bought probiotic, or a suppose that expired professional product, I’m going to go for the supposedly expired product, I’d go for a five year old professional probiotic, then, you know, on the shelf today consumer level.

Dr. Justin Marchegiani: Yeah, exactly. And also a lot of the probiotics or supplements that require refrigeration on the warehousing side, a lot of times you’re just not going to get that on Amazon, you’re not going to get that level of specificity just because that’s not how their warehouses are set up. And so with ours, we make sure that that refrigeration components is there because we’re working with patients and we need we need that potency, because we’re trying to get clinical outcomes, right. We’re trying to sell and provide a clinical outcome for the patient. And if we’re just providing products that aren’t meeting that standard, we’re not going to win. And of course, we want to be successful on that front.

Evan Brand: Yeah, yeah. Well say Well, I think we covered a lot of it. So the mushrooms are beneficial Lion’s Mane the mushroom is amazing for the brain, but for the gut also Chaga mushroom would be great reishi mushroom could also deserve a good mention, you hit upon the amino acids. So the glutamine or the various types of glucose amines involved. We love amino acids, we use those all the time you mentioned like collagen also being you know, part of that makeup, we hit on some of the herbs like the the licorice, or the dgl version of it, the marshmallow, we like to use a lot, we hit upon the aloe, and then we hit the probiotics, I think those are the big categories. And then the enzymes we hit that too.

Dr. Justin Marchegiani: I think we did a really good job hitting a couple and I just I really want to plug in concepts, right? Like a lot of people, they just try to throw information at people and and try to memorize that. I think that’s not beneficial. But if you can just understand concepts, right? A concept is just something that sticks. You either get it or you don’t. And so we try to use a lot of analogies and understand we try to plug in a lot of the concepts of root cause versus palliative cause. We try to get you to think about, hey, if this helps, why does it help? is it just an anti inflammatory? is it helping just improve better digestion? is it helping your immune system? is it helping your adrenals and helping you that your body’s natural process to build back up that gut lining? What’s the underlying mechanisms if you understand that, then you see how it plugs into the greater matrix of healing.

Evan Brand: Yeah, I mean, I agree 1,000%. So, I think the big concept of today is Yes, here are some things here are some nutrients you can use. However, we really want to make sure you’re testing, not guessing. So if you do need the aloe to calm the gut for now, you need the enzymes to help improve digestion. For now, you notice that HCl is helping with your heartburn or you notice that the enzymes are reducing your bloating, or your burping or your gas. Great, but what led to all that in the first place? What led you to need the aloe because you had gut inflammation, what led you to need the enzymes, that’s where somebody like us can come in and help you figure that out and plot it on paper. And, you know, we’ve been through the trenches personally. And clinically, we’re always improving upon herself. You know, I work on my children, I know you work on your children, we’re giving our kids things to help their guts, I mean, so this is like a, there’s no finish line, I don’t want people to think, Hey, I just do this aloe for a month, and then I’m done. You know, there’s not a finish line with the gut, we’re constantly being exposed to new toxins and new pathogens. We’ve even seen with the virus that’s been going around a lot of issues with the gut there, we’ve seen a lot of issue with tissue destruction in the intestinal tract. So who knows? Right now with the 5 10 year outlook of the GI health in the US is right now, our guts are notoriously bad, due to glyphosate and other things, damaging them. So just a quick note, you kind of started with the diet all and with the diet 100% organic is important, if you’re going to go buy all these probiotics, but yet, you’re going to eat strawberries with an average of 22 pesticides on them. If they’re not organic, you’re wasting your frickin time and your money because we know all those pesticides are just killing the beneficial bacteria in your gut that you’re trying to re inoculate or repopulate with. So please go organic, you know, before you spend money on probiotics.

Dr. Justin Marchegiani: Exactly. And then also how long do these probiotic strains last in your gut, I mean, a lot of times, you’re going to see the data show in about one month or so. So that they don’t stay forever. So when you take a probiotic, it’s not like it’s there forever. So it’ll it’ll hang around typically for a month, it’ll help with a nutrient synthesis, it’ll help with nutrient absorption, it’ll help with inflammation, modulating the immune system, there’s some data that maybe the spore based probiotics hang around a little bit longer, and they may help proliferate the growth of other beneficial species. So just think when you take a probiotic, it’s not forever. Now the goal is that we’re getting some level of fermentable foods in your diet, whether it’s from sauerkraut, or low sugar kombucha, or some kind of fermented pickle or something, or, you know, cultured coconut milk or potentially high quality raw milk if you can tolerate it. So you know, that’s typically how we’re getting exposed to probiotics more on a day in weekend kind of situation. If you’re someone that can’t get that level of exposure with fermented oils from food, then you probably want to be on a probiotic a little bit more frequently, if you’re not getting those fermentable. So we just got to plug and play where we’re at. I think our ancestors probably did more fermentable foods, which is ideal. But if we can’t we plug in a good quality probiotic, or at least throw in something every couple of months, just to kind of fill in the gap to make sure we’re getting exposed to those good for mandibles.

Evan Brand: Yeah, great point, I just want to highlight what you said too, which is like your gut bacteria are actually going to help you with your health in other ways. So once gut bacteria optimize your healing the gut, you’re making neurotransmitters the way you should you’re making serotonin, you’re making things to improve yourself, you’re making B vitamins to help your energy and your mitochondria. So this is why I really the gut, I mean, we just we can’t stop talking about it because it literally is the foundation.

Dr. Justin Marchegiani: Exactly. So just kind of want to make sure that is understood. And that makes sense for everyone. We’ll put a list of recommended products down below. So you guys have access to those you want to support us support the show, we appreciate it put those down below. Also, if you guys want to reach out to Evan brand, head over to EvanBrand.com, Evan is there for you guys worldwide. And again, I’m there for you as well, justinhealth.com, Dr. J myself, there’ll be a little link button, you guys can click and reach out to us we are available worldwide to help you guys help you help support y’all. We want to make sure they have the support you need. And you have a good comprehensive plan to get what’s going in the right direction if you’re not having success. And then also just try to apply one thing today as well. If you’re having if you’re overwhelmed, and you’re having a sticking point great to reach out, if not just try applying this information, we want to really help as many people as possible. And we know we’re going to help many more people than we actually see in person with this information. So just make sure you’re applying it. And if you are enjoying it, share it with family and friends that could also benefit put your comments down below. Let me know the best part that you liked about this what resonate with you the most. And give us a like and share as well. We appreciate it.

Evan Brand: Yeah, and if you’re on the apple listening, if you’re on your Apple podcast app or Stitcher or wherever else, give us some stars, let us know what you think the show deserves between us both we have I lost count, but it was somewhere over 705 star reviews for our podcast in between our various feeds. So please give us some stars. Give us some sentences give us a blurb on whether you still call it iTunes or Apple podcast. We’d love to beat out people that are not clinically oriented. There’s still like top health podcast out there that it’s just theory theory theory theory. And then we have to like recalibrate people’s theories because they’re not clinically based. So we would love to beat those people. How do we beat those Before we go higher in the charts, how do we do that? With your reviews! So we have a some stars. 

Dr. Justin Marchegiani: Thanks to all you guys have a phenomenal day. Take care.


References:

https://justinhealth.com/

https://www.evanbrand.com/

Audio Podcast:

https://justinhealth.libsyn.com/the-top-5-nutrients-to-address-gut-inflammation-and-leaky-gut-podcast-339

Recommended products:

Amino Acid Supreme

TRruKeto Collagen

TRUCOLLAGEN (Grassfed)

Probio Flora

Enzyme Synergy

Betaine HCL Supreme

Genova NutErval

 

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The entire contents of this website are based upon the opinions of Dr. Justin Marchegiani unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Justin and his community. Dr. Justin encourages you to make your own health care decisions based upon your research and in partnership with a qualified healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Dr. Marchegiani’s products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using any products.