The Leaky Gut and Hashimoto’s Connection


Most bacteria in foods that slips through is a big stressor that can wind up the immune system and start attacking the thyroid gland. If one wants to get to the root cause and get the immune system boosted, start where it is mostly found, at the gut.

Today’s talk focuses on the root causes of leaky gut and its connection to Hashimoto’s. Listen as Dr. Justin Marchegiani explains the underlying mechanisms, how most thyroid issues and the underlying root cause are autoimmune in nature, and how the gut can affect the immune system. Stay tuned for more!

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

00:27    Hashimoto’s

01:49    T3-Deficient Thyroid Hormones

03:58    The Immune System

05:29    Steps to Help Address Autoimmune Attack

Dr. Justin Marchegiani: Hey guys this is Dr. Justin Marchegiani here. Today’s video is gonna be on leaky gut and Hashimoto’s, autoimmune thyroid issues. We’re gonna dive in to the underlying mechanism, we’re gonna talk about how most thyroid issues and the underlying root cause are actually autoimmune in nature, and we’ll talk about how the gut can affect your immune system. So, let’s dive in. Before we do that, give me a thumbs up, hit the bell so you can get notifications of future videos and our awesome live Q&A videos too.

Alright, so, off the bat, we have Hashimoto’s which is an autoimmune condition that affects the thyroid gland. That’s essentially when we have antibodies that are attacking our thyroid tissue. We have TPO antibodies that may attack the inter-cellular enzymes in the thyroid gland, we may have thyroglobulin antibodies that are attacking outer surface proteins of the thyroid. And over time, that gland is gonna be stabbed and attacked by all these B cell infiltration, these are parts of the immune system that are coming in and attacking, and that thyroid can spill out, spew out thyroid hormone which can make us feel even hyper, uhm off the bat ’cause hormone comes out, it gushes out, but then over time, that hormone can be depleted because your thyroid follicle can only hold about maybe 3 months or so of thyroid hormones. So, over time that autoimmune attack can really deplete that thyroid, and of course the inflammation in this tissue can affect how thyroid hormones interact at the receptor site level. Every single cell your body has, a receptor site for thyroid hormone, so the more inflammation we have that can affect how s- a receptor sites and the hormone interact with all these inflammation and antibodies, and of course, as we attack that thyroid gland, we’re gonna lose functional tissue, functional aspects of the thyroid gland that are actually producing thyroid hormone. So, over time, we may need to actually be on a thyroid hormone replacement.

And again, a lot of people may not do well with the conventional thyroid hormone partly ’cause of the fact that it’s missing T3 a lot of times; it’s a synthetic T4. A lot of times there can be additives in there, gluten-like cross-reactive molecules or compounds that can exacerbate the immune system. And a lot of times these compounds, they just have T4 so you’re not really having the full T4, T3, and then even the other metabolically active components called T2, T1 and T0. So, when you give T4, there’s an assumption that it’s gonna go downstream to T3, and that may not happen. Again, check out my Thyroid Reset Summit at I interviewed 30 amazing experts and we go into a lot of these things. But, there’s an assumption that T4 goes to T3 and I test patients, I tested thousands over my career, where I would say about 80% don’t make that conversion optimally. So they do better with a natural thyroid glandular, some even may need T3. But, we need that T4 to T3 conversion, we need to add in that full spectrum of glandular that actually has the T3, and we may even wanna add in additional nutrients that are gonna help with that conversion and activation. Zinc, magnesium, selenium is really important, the major enzymes that’s cleaving the iodine molecules off the thyroxine that which is what thyroid hormone is. T4, thyroxine, 4 molecules of iodine, and we pull one of those molecules off that and becomes T3. That deiod- deiodination, pulling off that iodine is a selenium-based enzymes. So we need healthy levels of selenium to be able to make that conversion happen. Uhm, also, other nutrients are really important like I mentioned, zinc, magnesium. CoQ10 is really important for the autoimmune attack, uhm, so is magnesium, so is selenium, so is copper, so is vitamin A, really important. Glutathione is also really big and important too because glutathione comes from the liver, and when there’s liver stress, there tends to also be glutathione stress as well. So we have to address it from all angles. Liver, gut, right? And the gut is so important because that’s where most of the immune system is.

So, we come back to the title of the video which was “Leaky Gut and Hashimoto’s”. Well, most of your immune systems’ in the gut, in the GALT, the Gastric-Associated Lymphoid Tissue, the Mucosal Associated Lymphoid Tissue. And when that gut’s leaky, we’re gonna be activating and calling on our immune system to calm and be more active. And, essentially foods and bacteria that are slipping through, our immune system will be reacting to those and attacking those. And that can be a big stressor on our immune system, and they can wind up our immune system so it can start attacking the thyroid gland as well. So, we have to get to the root cause of the leaky gut which could be food-based, it could be in a combination of poor digestive compounds, poor digestive enzymes, HCL, bile salts, infections could be at play. We know, infections wind up the immune system, infections like H-Pylori, blasto, or lyme, borrelia burgdorferi, uh, yersinia enterocolitica, these infections can and make the gut more leaky, wind up the immune response and can exacerbate the autoimmune attack on the thyroid. So, get to the gut, get to the nutrients. Selenium’s really important ’cause it calms down the immune system and lessens the immune attack in the thyroid. There’s a lot of studies showing that selenium can help reduce thyroid antibodies, so can CoQ10 as well. So, things that are anti-inflammatory, curcumin, resveratrol, they can calm down some of the immune response and they can help lessen that autoimmune attack. You also have to get to the root cause of the gut underlying issues.

So, number 1, understand the ideology. Number 2, if you need thyroid hormone replacements, we may have to come in there but you need to see a good functional medicine doc that can look at it. Number 3, support the nutrients that thyroid needs to make the thyroid hormone, right? Thyroxine, be careful with iodine, that can exacerbate autoimmune attack, vitamin A, zinc, CoQ10, magnesium, right, really important. Little bit of copper, a good healthy paleo template, work on the liver, work on the adrenals which help with that thyroid conversion, get to the underlying cause of why that gut is leaky. 50 to 98% of thyroid issues are autoimmune in nature. So, you really wanna make sure you’re getting to the root- underlying cause of why it’s there.

So, head over to You wanna click in deeper with myself and my colleagues that work on these situations. Click below, schedule a consult with myself and we can dive in deeper. Hope this information was very helpful, hit the bell and subscribe, appreciate it, leave all comments below. I wanna know what you think, and I wanna engage in a deeper conversation with you on this topic.

Alright, thanks a lot, have an awesome day! Bye now.



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The entire contents of this website are based upon the opinions of Dr. Justin Marchegiani unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Justin and his community. Dr. Justin encourages you to make your own health care decisions based upon your research and in partnership with a qualified healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Dr. Marchegiani’s products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using any products.