Overcome Sleepless Nights and Frequent Urination: Effective Strategies for Better Sleep and Health with Evan Brand | Podcast #417

The video discusses the root causes of sleepless nights and frequent urination and provides strategies for addressing these issues.

Highlights:
• Sleepless nights and frequent urination can be caused by various factors, including hormonal imbalances and toxins.
• Hormones such as vasopressin and aldosterone play a role in regulating urination and can be affected by blood sugar levels and electrolyte balance.
• Toxins can disrupt the hypothalamic-pituitary-adrenal (HPA) axis and lead to sleep disturbances and increased urination.
• Strategies for addressing these issues include stabilizing blood sugar levels, supporting adrenal health, reducing toxin exposure, and using binders to remove toxins from the body.
• For men, prostate inflammation may contribute to frequent urination, while for women, low progesterone levels can affect GABA and lead to anxiety and restlessness.

Dr. Justin Marchegiani: Hey guys, it's Dr. Justin Marchegiani. Welcome to the Beyond Wellness Radio podcast. Feel free and head over to justinhealth. com. We have all of our podcast transcriptions there, as well as video series on different health topics ranging from thyroid to hormones, ketogenic diets, and gluten. While you're there, you can also schedule a consult with myself, Dr.

Dr. Justin Marchegiani: J, and or our colleagues and staff to help dive into any pressing health issues you really want to get to the root cause on. Again, if you enjoy the podcast, feel free and share the information with friends or family. Dr. Justin Marchegiani And we are live here, Evan Brand, Dr. J here in the house. Evan, how are we doing today, my friend?

Dr. Justin Marchegiani: Dr. Evan Brand Hey, doing awesome. Dr. Justin Marchegiani Excellent. Well, we were chatting before the show, we're gonna be chatting about overcoming sleepless nights, frequent urination, what's the root cause, what can we do about it. So really excited to dive into this topic. This is a common one that we get, you know, frequently with our patients.

Dr. Justin Marchegiani: So we're gonna dive in and talk about getting to the root underlying cause. How are you doing, man? Dr. Justin Marchegiani Oh, doing

Evan Brand: great. Well, I'm sleeping better than I was years ago. I was telling you before we hit record, like this topic really became very critical for me because I was up three, four, five times a night.

Evan Brand: And it was kind of this chicken or the egg question. It was like, well, am I up because I have to pee like the full bladders telling me to get up and pee? Or is it just something else is screwing up my sleep? And Oh, by the way, I might as well pee while I'm up. And so you start doing that a few nights per week.

Evan Brand: That turns into a few weeks per month and before you know it, you're just totally drained and your performance during the day is impaired. Now you have brain fog and cognitive issues during the day. So really how well you perform during the day is really based on how well you perform at night. And if you're not getting that full recovery, it's a huge problem.

Evan Brand: And so fortunately for me, I can sleep through the night now. But it was a dream of mine and it took me literally years to be able to sleep through the night. Occasionally, I'll still wake up once or so and there's different times of the night that you and I can talk about when people are waking up and what that may be linked to but this is a huge problem.

Evan Brand: Insomnia is a massive problem and the Ambien and Xanax and lorazepam and the conventional sleep or anxiety medications are not the root cause here. That's not a deficiency of pharmaceuticals is not gonna be your problem.

Dr. Justin Marchegiani: I agree. I mean, one of the first things I look at when we have sleep issues. So first off is a hormone from the hypothalamus called vasopressin or anti diuretic hormone, ADH for short.

Dr. Justin Marchegiani: I dislike when they put double negatives in, in names. So a diuretic hormone, it helps you pee. And so an anti diuretic hormone, I just like it. It's the anti pee hormone. Right? The anti P hormone. So, ADH anti P hormone. So, when you inhibit the anti diuretic hormone, right, two negatives equal a positive.

Dr. Justin Marchegiani: Right? So, when you inhibit ADH, it's pro Ping. It makes you pee more. And ADH or vasopressin, which is made by, you know, stimulated by the hypothalamus, comes out from the posterior pituitary. It's gonna connect with and stimulate glucocorticoids. from the adrenals, which are going to be your cortisol and which are also going to be your aldosterone.

Dr. Justin Marchegiani: They're going to have a major impact on your adrenals. So again, your glucocorticoids are going to have impacts on inflammation and on blood sugar. So one of the best things you can do to prevent. Dr. Justin Marchegiani Let's just say overstimulation of the adrenals is making sure your blood sugar levels are stable.

Dr. Justin Marchegiani: You're not eating too much carbohydrate, putting too much processed carbs into your bloodstream. Let's say you have a typical normal blood sugar of 100 milligrams per deciliter. That's your, you know, your typical blood sugar reading. Let's say you're at 90 to 100. 100 milligrams per deciliter is one teaspoon of sugar.

Dr. Justin Marchegiani: One teaspoon. So let's say you have something like a soda, an hour or two before bed, right? 12 ounces. That's 10 teaspoons. So what's your body doing to clear out nine teaspoons? It's having to make a whole bunch of hormones to convert that to fat, or it's either burning it up if you're active, or It's converting it to fat, lots of inflammation, may even dump it out the urine.

Dr. Justin Marchegiani: It's also gonna cause a lot of dumping of B vitamins, it's gonna cause dumping of electrolytes, it's gonna cause a lot of dumping of of magnesium as well, so stress handling nutrients. And so, when you have ADH or vasopressin talking to your adrenals, you have this glucocorticoid thing, so making sure our blood sugar is really stable through good, healthy macronutrients, good protein, good fats.

Dr. Justin Marchegiani: just in the carbs that kind of where you feel is best, you know more fruit, you know, more vegetables, and like lower sugar fruit, less fruit, less starch, and anything more processed. If you're doing starch, that's fine. And the next thing is aldosterone. Aldosterone is gonna be made by the adrenals.

Dr. Justin Marchegiani: It's a mineral corticoid, and that helps hold on to your electrolytes. So, one of the biggest things with vasopressin or ADH is you have this diluted urine, right? And so, if we add in more electrolytes, that concentrates the urine a lot better, and we're more likely to hold it when we have more electrolytes.

Dr. Justin Marchegiani: That's why one of the big things when you drink, for instance, you're going to knock down your ADH, and it also causes a depletion of a lot of your electrolytes. It's part of the reason why you feel hungover the next day is there's a lot of electrolyte depletion slash dehydration. So if we look upstream, we have this ADH, and we have the vasopressin, and then we have to dive in deeper to the adrenal glands, which is going to be the cortisol and the mineral corticoids, and then the different things we can do there from hydration, dehydration, dehydration, better quality water, adding electrolytes, even different herbals like ashwagandha rhodiola, all can help modulate some of those mineral corticosteroids, even maybe adding in a little bit of licorice, which can even mimic it and help produce more as well.

Dr. Justin Marchegiani: So there's a lot of different inputs that we can add, and that's only one element, but I'll let you riff, Evan.

Evan Brand: Yeah, I mean, this thing can get complex. We could turn this into like a three hour master class here, but on the cortisol piece, you kind of alluded to, you know, we could easily run saliva or urine and look at your rhythm.

Evan Brand: Sometimes we'll see these abnormal spikes where the cortisol at night is a problem and we can use specific things to lower it. I've also seen where when cortisol is too low, and that sounds weird, but when cortisol is completely flatlined, that also causes sleep problems for people.

Dr. Justin Marchegiani: Well, because when you have cortisol that's low, right, you don't have the blood sugar regulating effects.

Dr. Justin Marchegiani: For the blood sugar stabilizing effects of cortisol to help buffer things. And so if you throw a bolus of carbohydrate, it's too much for your body. You get this increase in glucose, then you get this drop, this, this spike of insulin, which brings the blood sugar back down and then the blood sugar can crash.

Dr. Justin Marchegiani: And so when we're, when we're surging adrenaline and cortisol. Or even if we're just surging blood sugar and then surging adrenaline to bring that blood sugar that's low back back up, that can definitely stress out the electrolyte system. And it's also a sign if your cortisol is low, then your mineral corticoids are also probably low, which is where aldosterone is made in the adrenal glands.

Evan Brand: Yeah, well said. So the adaptogens have helped me significantly with my sleep, with my circadian rhythm, with the cortisol rhythm. The other impact is toxins. You know, you and I talked probably, I don't know, three, four more years ago where I was starting to experiment and figure out that when I personally and clinically was using binders, I was noticing that me, my wife, and many, many clients were saying, hey, I sleep better.

Evan Brand: And so if you look at Like Dr. Shoemaker and some of the work where he talks about the whole biotoxin pathway, you know, he talks about leptin receptors being blocked by inflammatory cytokines. When that happens, that then affects your MSH, so the melanocyte stimulating hormone. And then when the MSH gets messed up, then often that is related to number one, you can't tan.

Evan Brand: But when you have low MSH, you can measure this on blood. You'll start to have more gut issues. So now you could be waking up with gut issues and then also reduced MSH that can also decrease the anti diuretic hormones. So now you have super thirsty, you pee a lot. And for me, static electricity, that was another weird one that people don't think about, but if you feel like you're getting static shocks a lot, that could be related to low MSH and therefore reduced production of ADH.

Evan Brand: So if you look up like biotoxin pathway anti diuretic hormone, you can read about it, but what is the takeaway from it? Well, it's just, you gotta try to help reduce exposure to the toxins and then try to get the stuff out of you. You can use, I don't, I don't prescribe it, but I've seen people taking.

Evan Brand: Like some of that vasopressin, like I believe you can probably get that compounded. Yeah, you can

Dr. Justin Marchegiani: get away with sinus one,

Evan Brand: yeah. I haven't messed with it though, I haven't, I haven't needed

Dr. Justin Marchegiani: it. And so just to make sure what I heard, what you said correctly, you were saying that melanocyte stimulating hormone, is it depleted with toxins?

Dr. Justin Marchegiani: It's lower with toxins? That's right. So you, could the toxins hypothalamus to,

Evan Brand: to secrete that? That's right. Yeah, there's some kind of connection between leptin too, like the inflammation from the cytokines from the toxins screws up and cuts down MSH and then that cuts down ADH as well.

Dr. Justin Marchegiani: Yeah, it's like weird, right?

Dr. Justin Marchegiani: There's a lot of feedback loops, hypothalamic, that just means the hypothalamus, pituitary, adrenal or thyroid. These feedback loops get disrupted with inflammation, right? And then you could put toxins as another driving factor of inflammation. So when it comes down to it, it's like, well, why is it disrupted?

Dr. Justin Marchegiani: And then what can we do to get it back on track? And so if it's toxicity from mold, then okay, we have to figure out where we're getting exposed to and try to one, just try to limit our exposure environmentally through clean remediation process. high quality air filtration, just something that's gonna be simple out of the gate.

Dr. Justin Marchegiani: That's gonna lessen our load, that's gonna help. It may be coming in and adding in some binders, it may be bumping up glutathione levels, it may be supporting methylation. And so, there's a lot of different ways we can look at it. And of course, we know the liver hour, Kind of according to Chinese medicine, when we detoxify and when the liver really dumps, again, it's gonna dump into the liver, gallbladder, into the gut, usually around 2 to 3 a.

Dr. Justin Marchegiani: m. So, if we're overly active, dumping a lot of toxins in the middle of the night, that could be something that overstimulates us and wakes us up. So, if we have toxicity and we're having I dumped it, you know, having some binders in there before bed. So when those toxins get dumped, we can at least bind it up and then keep it moving through the intestinal tract and not let it get reabsorbed would also be a good strategy.

Dr. Justin Marchegiani: Would you agree? Evan

Evan Brand: Brand Yeah, well said. I mean, I went from three, four, five times a night to go pee to maybe once, sometimes zero, just by adding binders before bed. So it was a significant change. Now, some older men, it could be prostate related. We've seen clinically, we're just using some prostate support nutrients that's helped reduce it.

Evan Brand: So maybe if you've had an elevated PSA, we could at least give a brief mention to that being related. So there's prostate inflammation, maybe that's affecting your bladder and that's waking you up to females. What about the progesterone piece? I know you love talking about progesterone. You're really focused on that.

Evan Brand: Is that a piece too, because maybe. Lack of progesterone is affecting GABA and then these women are more anxious, more irritable at night.

Dr. Justin Marchegiani: Dr. Justin Marchegiani Yeah, I mean, I think especially the average woman that's coming off of a stressful day, you know, working or dealing with kids, they're going to have that sympathetic nervous system in overdrive, right?

Dr. Justin Marchegiani: And so GABA, the GABA chloride channels are going to be more open with progesterone. So that's going to take that sympathetic nervous system down and bring it back into the parasympathetic where you're resting, you're digesting. So that, that's a key thing. We could even add in more nutrients, more GABA precursors like GABA itself, or theanine things like that, things like herbs that are gonna work on those pathways, whether it's ashwagandha, or whether it's holy basil, things that are valerian lemon balm, melissa, like these are different herbs that are gonna upregulate our GABA pathways, which are gonna allow us to switch from sympathetic to parasympathetic.

Dr. Justin Marchegiani: Some people we can even go into a nice cold shower. Cold showers can help activate that parasympathetic response as well. And I would say, most women, if you're needing progesterone, you know, why? You know, more than likely, progesterone, it gets pulled downstream to pinch hit for cortisol. Kind of like dopamine with adrenaline.

Dr. Justin Marchegiani: Progesterone gets pinched hit and gets pulled downstream to deal with cortisol and your glucocorticoid stress hormones. And so, when you're chronically stressed and inflamed, you'll pull that. Now, We can add in progesterone, it's fine, but you just have to make sure you're getting to the root cause of why you're overly stressed, and if it's just, you know, life being what it is, well, you have to make sure then you develop the good sleep habits, the good nutrition habits, the good supplement habits, to counterbalance it, because if you burn the candle at the both ends, you know, it's going to be just a little bit longer before you start to have chronic health issues, so at least try to work on your building up at the same level that you're breaking down, so you're not going negative, so to speak.

Evan Brand: Yeah. I mean, it's a battle. I mean, especially with kids too. You've got two, I've got three. So for parents listening, they really have to treat parenthood as an Olympic sport in a way. I mean, you've got to be diligent about the self care strategies. I mean, I talked to so many parents who, you know, they want that evening time after the kids are in bed.

Evan Brand: So then they stay up too late. They're up till midnight because they're trying to get stuff done. They couldn't get done while the kids are awake. So now they're sleep deprived because they got to get right back up at six. So you're operating on this sleep deficit. And then this is compounded by you wake up, have no blood sugar stability.

Evan Brand: You go straight for coffee. You haven't stabilized your blood sugar and then you, you know, you fall apart. So this thing compounds over time. One bad night of sleep is probably not going to destroy you. But if you set up your life in a way where you're up every night, maybe you're checking your emails or you're going on Instagram.

Evan Brand: Do you remember hearing this quote? There was some quote I heard before. I think this was regarding Netflix, where they were saying the only competition was sleep. And so basically, you know, a lot of these social media internet companies, they know that everything that they're putting out is so addictive.

Evan Brand: I have teenagers as clients that tell me they're up on TikTok in the middle of the night for two hours and they're just scrolling and they literally just cannot stop scrolling because they're just getting such a high from it that they can't sleep because of the scroll, too. So, I mean, like I said, we could turn this into a three hour thing, but I'm just throwing out some other potential, like, lifestyle factors in this thing.

Evan Brand: So, I'm, personally, I know you and I both do our phones. We can do the red at night. Turn off the blue light at night, but just the mental stimulation of reading stuff, keeping yourself worried about news or media or emails or how many people liked your photo. You know, that's also a potential pitfall.

Dr. Justin Marchegiani: Yeah, man, the big strategies, you know, if you want to, it just depends on how stressed your nervous system is because the healthier you are, the more your nervous system can adapt.

Dr. Justin Marchegiani: Right? Yeah. So we want you to be healthy. So yeah, you could watch some Netflix, turn off the TV and then with 20 minutes to be asleep. That's ideal. Some people's nervous systems get wound up so much. They need time to decompress. So you have to look at it and say, where are you in that situation and then what, what strategies can you implement if you are that person that gets easy to wound up and needs more time?

Dr. Justin Marchegiani: So I mean, big strategies would be having some kind of a blue light blocking glasses on before bed. I wear glasses before bed. When watching TV and I make sure I have 99 percent blue blocking lenses in them. So I try to lock down the blue light. You can add an additional theanine or ashwagandha or do an Epsom salt foot bath.

Dr. Justin Marchegiani: Those are good strategies. You can dim the lights a little bit, right? You can try to say, okay, I'm done at this time. I'm going to, you know, read the Bible or some kind of a spiritual text or just something that really gets you in a parasympathetic, relaxing state. So you can calm that nervous system down.

Dr. Justin Marchegiani: Some people, maybe go jump in a cold shower. Right. So it depends on how, where everyone is. Right. And of course, if you're waking up to go pee, you know, we're going to be saying two to three hours, probably don't hydrate before bed. So if you're going to bed at 10, we're eating at seven. you know, I'm going to say let's hydrate before and then maybe, you know, two hours before bed.

Dr. Justin Marchegiani: So let's get our hydration in, make sure there's good electrolytes in there. And then if you're someone that's trying to do the right thing, but you're drinking a lot of RO water, reverse osmosis, but you're not adding in the electrolytes, make sure you get the electrolytes in because getting the sodium up.

Dr. Justin Marchegiani: along with the potassium too because too much sodium can also lower potassium. So, as long as you get some sodium potassium in it, that will definitely help with the adrenals and that will help your urine concentrate better. So, you're allowed to, you're gonna hold more of it into your bladder and not pee it out and keep it very diluted if you will.

Dr. Justin Marchegiani: Evan Brand Yeah, well

Evan Brand: said. I mean, two other roadblocks here. Now, you know, the interesting thing about YouTube, right, is there'll be a quote health influencer on YouTube and they'll take an entire little like baby, baby subject and turn that into an entire video. So I hope that you all listening and watching, you get the difference here as opposed to just like internet researchers that Dr.

Evan Brand: J and I are actually clinicians. We're in the practice helping people. And so we can't just zoom in on one little thing for you just to make a YouTube video sexier, right? We're trying to encompass this whole issue as a whole and help. How we approach that from a functional medicine perspective. So I hope you get that because we could zoom in and make a video longer than it needs to be by just doing thyroid and sleep.

Evan Brand: And we could do a whole hour on thyroid and sleep. Yes, Dr. Jays wrote a book on thyroid. We could hit that all fricking day. However, we wanna help make sure that you know how to zoom out. and capture the big picture. So two other things I'll throw in here. It would be definitely thyroid issues. We've seen a lot of women with autoimmune thyroid issues where at night all of a sudden they've got this attack on the thyroid and boom, their Hashimoto's is flared and they're really anxious and they can't sleep.

Evan Brand: And then gut issues.

Dr. Justin Marchegiani: T3 can impact sleep too. So if you have low T3, it can definitely impact it. But you know, when we look at hormones, we're looking at adrenals, right? We're looking at the cortisol, we're looking at mineral corticoids, we're looking at female hormones, and then also thyroid. And if there's antibodies too, then that tells me we have, we need more severe diet strategies in there as well.

Evan Brand: Go ahead. Evan Brand Yeah. And then the gut piece too, right? I mean, full moon just passed a few days before we've recorded this here. And I noticed my kids, they were a little bit restless. I heard a little bit of teeth grinding. I'm like, okay, maybe there's some gut bug stuff here. So we can always run a stool test on you, your family members, your children.

Evan Brand: If there is a chronic sleep issue, we can investigate. I had parasites years ago. And that definitely screwed up my sleep. So if we see these gut infections, can we come in and just use herbs to address those and see how well we do? Yeah, but it's better to get the data. So once again, we're going to say, get the proper labs done.

Evan Brand: As you know, we can't fix everything here and just this recording. So we've hopefully highlighted, we may need to investigate thyroid with you. We may need to investigate hormones using saliva or possibly urine. And then we could also investigate the gut using organic acids or stool testing. And. I know you see this too, but it's mind blowing how many prestigious hospitals, Mayo clinic and Cleveland clinic, and all these like functional medicine I don't know these white ivory towers, right.

Evan Brand: Of all these prestigious places and these prestigious doctors and these people that have spent 20, 30 K. And they don't even have an organic acids test done when they come in. It's like, what you went to XYZ clinic, you saw XYZ doctor with a hundred thousand credentials after his name. And it didn't even run an organic acid test.

Evan Brand: No, I've never heard of it. So there's shockingly bad practitioners out there that are attaching functional medicine to their name because it's become trendy. And so we want you all to make sure you're actually getting the right. The real labs that are actually going to help you and five, 6, 000 of blood testing is likely not necessary for most of these chronic health conditions, especially the sleep issues.

Dr. Justin Marchegiani: I mean, the issue I see with a lot of conventional medical doctors that market functional medicine is they'll just look at some of your symptoms, throw some nutrients or herbs that would help with the symptoms and maybe some hormones. To get the hormones straight without fixing why is that off to begin with, why are you low on those nutrients, how's your gut function, is there any toxic exposure, what's lifestyle look like, there's a lot of other, like I call them root cause drivers of why that person is in the position they're in, they don't really look at that, they're still using Hormones or nutrients or herbs downstream to try to manipulate symptoms and they're not fixing the underlying systems upstream hormone gut detox immune or the underlying stressors, physical, chemical, emotional stressors that drove those systems to be out of balance.

Dr. Justin Marchegiani: So it's really important when you're working with your practitioner. It's always good to say, okay, well, what are we doing for symptoms downstream, and, and is the symptom relief just symptom relief, or is it actually fixing things upstream with the body systems, and also on the hormone side, and also one other component too, with hormones, we have BPH, benign prostatic hypertrophy.

Dr. Justin Marchegiani: As, as gentlemen have more exposure to androgens over their lifetime, testosterone will convert downstream to DHT, and DHT can cause prostate swelling over time. And so, there's natural things that you can do to get the DHT down. One, you can just get it tested, just see where it's at. Get your PSA looked at as well.

Dr. Justin Marchegiani: You can get that looked at. We can do natural things, such as soft palmetto, you know, 250 to 500 mg a day of a good quality liquid, you know, 85% extract. We can also do pumpkin seed oil, which is very high in zinc. Zinc also helps with DHT. Additional supplementation on selenium, pygmya bark, stinging nettle, all very helpful.

Dr. Justin Marchegiani: You have the pharmaceutical route, which could be Fidasteride one milligram or Proscar five milligrams. I always say try the more natural things first because less side effects. And then you can always go other interventions down the road, but also just get the inflammation down. Get your diet right. Get your blood sugar right.

Dr. Justin Marchegiani: Get the nutrient density in your diet dialed in. I tell patients just run your food through Cronometer, go to cronometer. com, put it's like MyFitnessPal, but it will also tell you micronutrients for all your food. Some people just have glaring deficiencies in magnesium, in potassium, in B12, and it's like, hey, you know, let's just start by like, okay, this food's really low in this, you're really low in this nutrient.

Dr. Justin Marchegiani: Let's just figure out what foods are high in that nutrient and see if we can get the nutrients through food first, and then we can come in with supplementation, and then we can use specialty labs to see, oh, do we need more than what's typically recommended? And that's where we bring in intracellular nutrients.

Dr. Justin Marchegiani: That's where we bring in organic acids. That's where we look at the gut and see do we have a a breakdown in the absorption process. Also, if the stress system is really high, we're burning things up at a way higher rate anyway. So what the DRI is or RDA is may still be too low for you as well.

Evan Brand: Yeah. And this is not a rare situation.

Evan Brand: Okay. So like when he's riffing these things off, you're like, Whoa, there's like a freak show. Poor guy, poor girl out there that he's talking about. No, this is like your average person, like nine out of 10, 90 out of a hundred people that we test clinically, there are these issues, even in people that are eating animal based, even people that are a hundred percent organic, even people doing paleo and no grains and no gluten and no dairy.

Evan Brand: Okay. So he's not talking about like the broken person that's in the checkout line at I don't know. McDonald's with an extra, extra, extra large soda and French fries. That's not the guy he's talking about. He's talking about people that are doing everything right on paper. So I want you to know that like, if you feel like you've done all the things and you're still suffering, this happens to the best of us.

Evan Brand: Even me, when I look at my labs, there's still stuff to improve. Even though I feel like I've done really good work and I've tried for a decade to improve myself, there's still room for improvement. And this is especially true for children. It's very rare that I find. Children with adequate levels of nutrients, whether this is a gut infection that's affected absorption or what.

Evan Brand: But I mean, we see kids all the time on their oat test. They're just low in everything. Also, they're low in brain chemistry. I don't think, you know, I've mentioned neurotransmitters yet. So let's just briefly, you know, give a nod to that, which is that if there's a brain chemistry problem, which could have multiple roots, that's going to affect it as well.

Evan Brand: Because if there's a low serotonin situation, you're going to have reduced ability to produce melatonin. And so, maybe some of those precursors for neurotransmitters can help to basically revitalize the brain, but then also improve sleep quality.

Dr. Justin Marchegiani: Dr. Justin Marchegiani 100%. And so, we look at it all we talked about the adrenals, electrolytes, hydration, obviously alcohol too close to bed can be an issue.

Dr. Justin Marchegiani: Now if you drink, try to keep it closer you know, hours before, but it worst case, we just maybe add some binders in there, some NAC, glutathione, try to drink a a mineral water in between to get your electrolytes up. If it's blood sugar stuff, we can always add in some collagen, some amino acids, maybe a little bit of honey for some fat, protein, blood sugar stabilization support.

Dr. Justin Marchegiani: We can work on prostate stuff if that's an issue. And then we can look at all the hormones. Is thyroid an issue? Is cortisol an issue? Is progesterone an issue? As you can see you know, the reason why when you go on the internet and you're like, what can I do for this? You got zero information about what is the right thing for you.

Dr. Justin Marchegiani: So when Evan and I are interviewing patients and talking to patients and doing a workup, I'm taking all the information in and we're lining up based on the balance of probabilities of what this person's going through, right? Based on what their labs say, these are the interventions from least invasive, most affordable to.

Dr. Justin Marchegiani: you know, most expensive, most invasive, right? So we always want to line it up in that way. And a lot of times when we just get the diet and the blood sugar and we just do a good baseline checking all the hormones and we start getting some stability there, a lot of these things go on its own, go away on its own because that bit, that foundation allows everything to sit on it.

Dr. Justin Marchegiani: And then we can get more nuanced with herbs or hormones or, you know, timing things up better or blood sugar stability or amino acids. We can really get granular or detoxification strategies, et cetera.

Evan Brand: Yeah. And you know, some of this may all sound very serious and intimidating, but we love this stuff. We do it all day, every day.

Evan Brand: And so it's a true passion. And we actually have fun doing this is, is may come across as like this serious conversation, but we're actually just having a blast being with you all here. And we love sharing this stuff. We love helping you to live a better life because at the end of the day, if we can help you sleep better, then you're going to perform better the next day.

Evan Brand: You're going to be a safer driver on the road. Think about how many accidents are happening with semi truck drivers and trucks. Other vehicle accidents, people that are getting run over because they were so brain fog, they hit a pedestrian cross in the crosswalk because they're so tired because they've got mold and they can't sleep at night.

Evan Brand: Right? So we're trying to put our dent in the world by making you all better people so that then you can give that better version of yourself to your spouse, to your children, to your customers, to your clients, to your business. Right? So that's what we're trying to do is just. Basically amplify what we can do personally for ourselves and turn that into you guys being healthier versions of yourself, and hopefully you'll spread the message.

Evan Brand: So if you need help, we'd love to be here for you. Dr. J that's Dr. Justin Marcagiani. Consults are available worldwide. We love helping you guys. So it's Justin Health. EvanBrand. com. If you want to reach out to Dr. J or me, EvanBrand at EvanBrand. com. And if you haven't had these proper labs done, you haven't had the proper workup done, let's at least start there.

Evan Brand: Let's get a few pieces of data on you and we could change your life significantly because you may have some glaring issue that we can find on page one of that oak test could transform your life and you could have been to 20 doctors and spent 20 grand and not even had that page one looked at yet.

Dr. Justin Marchegiani: Dr.

Dr. Justin Marchegiani: Justin Marchegiani 100%. Start with the foundation, work up from there. if you're stuck or need that little bit of help, you know, hire that Sherpa to get you to the top of the mountain so we can figure out what the best next intervention is. Save you a lot of time, effort, and money in the process. Evan, great chatting with you, my friend.

Dr. Justin Marchegiani: evanbrand. com, justinhealth. com. We're here to help, guys. If you want more support, love to see your comments down below. Let me know what's working for you. Something's helping, put it down below. People read these comments, I read them, I'm responding. It also will help with other listeners when they see things that have been, you Helpful clinically.

Dr. Justin Marchegiani: We're all about what's actually working. Evan, anything else you want to leave the listeners with?

Evan Brand: Mm hmm. I think we covered most of it I'm sure we could do a part two part three on this but figure out the toxicity issue figure out the stressful inputs at night If you're watching murder shows, maybe you need to change it to something a little more Romantic if you're watching like police shootouts, you know, you probably need to switch it to something else So

Dr. Justin Marchegiani: or just hit the pause button.

Dr. Justin Marchegiani: Hey nine o'clock that last hour I'm gonna go and read something more more chillaxing if you will or or Or go do some sauna, go do some go do an Epsom salt foot bath, put those blue blocking glasses on. It's a good first step for sure. Yup. Yup. Amen. Excellent, Evan. All right, man. Great chatting with you.

Dr. Justin Marchegiani: Everyone have a phenomenal week. Take care, y'all. See ya.