Boosting longevity and mitochondria are some of the things that people are so interested to know because they want to know the secret in living longer, as well as the quality in their year’s energy focused cognitive function. Join Dr. Justin and Bernd Friedlander as they talk about longevity, amino acids and a lot more.
Dr. Justin Marchegiani
07:30 Important Amino Acids
21:30 Fat Burning
Dr. Justin Marchegiani: And we are live is Dr. Justin Marchegiani in the house with Dr. Bernd Friedlander. Dr. Bernd. It's really exciting to have you on the show today. What's going on?
Bernd Friedlander: Oh, I'm just excited to be with you. Like always.
Dr. Justin Marchegiani: Well, I'm really excited here too. So let's dive in. I mean, you're, you've been in this field for 40 plus years clinically. Your functional medicine, also Cairo documented in the supplement industry for a while you work with athletes, you work with the everyday population. And you have a lot of experience on a lot of different topics. So I wanted to pick your pick your brain here, one of the first topics I wanted to dive into is longevity. A lot of people are interested in improving the in the amount of years they're going to live, but also the quality In their years energy focused cognitive function. What are some of the first steps that you see clinically that have really moved the needle in that department?
Bernd Friedlander: Well, I think a lot of it is, you know, we're looking at environmental factors and what dictates our lifestyle is going back 65,000 years ago when we were out and outdoors, and we had no computers, no cell phones, no technology, no EMR. So I think that is another problem we're seeing today because I think today, the youth of, you know, what we're seeing is indoors. They're indoors and working indoors and computers and cell phones and video games. So they're changing the quality of their life, but also it's affecting the brain chemistry of the brain. And, you know, depression, anxiety disorders is very high now, as you know, and I see a lot of that. And the other thing is everybody doesn't understand what's the right diet, you know, they all think, you know, they go on veganism they go in high protein, you know, diet, low carb diets, you know, a lot of it is activity also what do you do on a daily basis that dictates what you eat. But one thing I tell everybody in the morning as get a little sunlight in your eyes, so you start activating all those important neurotransmitters that the brain needs the mitochondria needs. And I always say have a good protein drink in the morning or a protein meal. And that means over EZA so software legs, and it's got to be pasteurized and I use ghee butter to get my day going, and I take about 30 grams of collagen every single morning and that's pretty much my diet and that sustains me to go through many hours throughout the day without really getting fatigue, mentally and physically and I don't really want to eat much. So that's sort of like what we call intermittent fasting. And oh, and that's the other big thing is, you know, is the quality of food versus what people eat, you know, and that's important calories in calories out. But what type of calories are we consuming today?
Dr. Justin Marchegiani: So that's really interesting. So I always tell my patients, you know, especially ones that have metabolic issues, adrenal issues, or thyroid issues, 30 grams of protein in that first 30 minutes, especially if we're having blood sugar, energy issues, those amino acids really they start the day they're going to provide building blocks for a lot of your neurotransmitters, your stress hormones, a lot of your you know a good chunk of your hormones that are peptide based, meaning amino acid base, and I start my day with about 15 to 20 grams of my true collagen in my coffee in the morning. I do just the carry gold, better unsalted add a little bit of vanilla extract there. So that's interesting. You have a very similar routine. Can you talk more about collagen and intermittent fasting so some would say having that collagen in the morning may throw you out of a fasting state are you technically still fasting or at least a modified protein fast with still fast with the collagen in the morning?
Bernd Friedlander: Well, here, you know I had a chance to meet Dr. And, and Marie Claire, both out of Einstein University has done a lot of work in the intermittent fasting scene. And the work I was looking at and working with was a tough itchy, you know, tough issues where we recycle the junk before it accumulates and causes DNA damage and damage. So one of the things that she discovered was if you eat, let's say, seven o'clock at night, and then don't eat another for 12 hours, the next day, you are creating what's called a typology. And that's what fasting is all about. You know, it's creating something where the body recycles the junk and utilizes for energy, rather than accumulation and damage and that's what happened. So, what I tell people is the first thing in the morning, you want to get that brain going, you want to get that body going, you want to keep IGF one insulin growth factors down, you want to prevent em tour pathways, which are all these two pathways. So the leading pathways to aging and disease and cancer and heart disease and diabetes. So the best way to do that is yes, fast 1214 hours from lung last meal to the next day, but have some protein and I think the best protein is something where you consume like cheese, eggs, something that you know if you like fish, but it is important that you don't go in the morning without having a good meal because it affects the rest of the day for you and how you sleep at night. So I think collagen is important, and I think collagen taken. There was a study that was done and I was involved 2030 years ago, with notch gelatin on A study similar to this where you take 15 grams of collagen, three or four times a day, you actually repair and regenerate tissue cartilage and bone much quicker and you prevent damage from exercise. That's the key is the damage that accumulates after exercise if we don't consume the right foods before and after.
Dr. Justin Marchegiani: Interesting I know a lot of those pathways that are being hit are the tour pathways. I want to talk about that in a minute. So having good amounts of collagen is a great start to the day and the thing I like about collagen is the amino acids are coming from typically connective tissue, we're not getting a lot of connective tissue, we're getting a lot of a lot more of the muscle kind of protein which is much higher and refining and with some of the college and you're getting a lot more glycine which is a good precursor for Luda thigh own. It's also good, good tissue and building blocks for your own connective tissue, hair, skin, nails, joints, and we're kind of a muscle meat based society so we're getting exposed to some different compounds too.
Bernd Friedlander: Exactly. And the other thing about, you know, collagen, it's very a non inflammatory of bone of all the proteins on the market today, including milk and cheese and eggs and all that there is some inflammatory mechanisms there. But when you take collagen, which are devoid of these three amino acids, which lead to em tour pathways, it's the only protein that does not have the three amino acids that cause oxidative damage.
Dr. Justin Marchegiani: Can you repeat those amino acids again?
Bernd Friedlander: It's tryptophan methionine and cysteine and they're the ones that were shown in research to have less oxidative damage-
Dr. Justin Marchegiani: Which is the precursor to five ACP and serotonin, melatonin cysteine, which is the glue to find precursor much higher and whey protein, and then methionine
Bernd Friedlander: methionine, yeah. Richard Miller did a lot of work in this area and so has a repeat and when I was Working in the caloric restriction diet discovered, that's why caloric restriction works, it's because you are eliminating these types of amino acids in your diet, you're really cutting down quite a bit of this. And so you're getting less of that. And therefore, you're, you're not causing oxidative damage or mitochondrial damage or thyroid damage, they lead to, you know, suppression of, you know, oxidation of glucose. And that's the problem. And it's well known that these amino acids can lead to em tour pathways, which can cause abnormal cells to grow faster, like cell cancers require the tour pathway, which are these amino acids, to allow them to replicate faster and grow.
Dr. Justin Marchegiani: And interesting. So essentially, what you're saying is we want to we want to keep the tour down. So if we can keep the proteins and again, at least starting the day off this way, kind of gives you the That, that 12 to 16, maybe even 18 hours of living some of those amino is obviously just not eating is going to decrease insulin. Anytime you have food, especially carbohydrate, little bit of protein and very little fat, you're going to start stimulating insulin, which is going to be a growth factor, it'll increase the IGF one. So you're saying, keep the insulin IGF one low, try to keep them methionine, cysteine and tryptophan down and we can do that by using collagen in the morning and that's also going to be keeping the tour down Is that correct?
Bernd Friedlander: Yes. And when you also take it at night, you are suppressing these amino acids from being developed at night, which are sort of stressors. These amino acids can lead to stressing the body by increasing cortisol levels and, you know, a nitric oxide and other areas of that area where causes mitochondrial damage thyroid damage and replication of cells the immune system especially at night
Dr. Justin Marchegiani: We don't want too much because we do know there's a lot of data on like, for instance 16, from whey protein having a really good impact on boosting gluten. And we know glutathione's good, but also tryptophan is very helpful. I mean, you know, the work of Julia Ross talks about tryptophan and helping with serotonin and mood and sleep issues. So is it just the sheer amount of it because we know there's some beneficial effects in the literature?
Bernd Friedlander: Yeah, but there's also a lot of research has shown that serotonin, which is also a culprit, and when it gets released from the platelets, it goes through the blood brain barrier, it carries through the album into the blood brain barrier, actually, it causes more problems their serotonin leads to depression, anxiety disorders, and it's also mechanism for Alzheimer's.
Dr. Justin Marchegiani: We talking about the amount of because we know there's a lot of studies and you know, a lot of clinical data on on using for instance, five HTTP and seeing lots of mood improvements. So how do you flush that out,
Bernd Friedlander: you know, It's interesting when five HTTP came out, it was used by a lot of patients of mine. And I gave a couple lectures and some of the lectures are Silicon Valley at the anti aging conference in San Jose by the program. I asked the people in the audience, I was sort of interested in finding out about five HDB. I said, How many of you take five HTTP, and half the audience raise their hands? I said, How many of you sleep well at night, and all and none of the five HTTP people really raised their hands? They weren't sleeping that great. They all answered by saying no, I don't get a complete deep sleep. I don't get a 567 hours sleep, so disrupts their sleep pattern because serotonin is also a stressor in the body. It's not just we need serotonin, but very little actually and serotonin also suppresses thyroid function and if you have a low thyroid and a high serotonin levels then it's a culprit to a lot of diseases especially you know Alzheimer's and we've seen in studies where MS patients that we've seen a lot of serotonin levels go up in the brain when they from MS patients done by a number of clinical studies at UCSF and also other clinics.
Dr. Justin Marchegiani: So you saying with everyone or just some people that serotonin at a higher levels and to be a problem.
Bernd Friedlander: everyone it's, it's, it's known to, you know, create a lot of disturbance in the proper function of the cells. It disrupts serotonin does disrupt mitochondria, NAD levels.
Dr. Justin Marchegiani: We just had I've had I've had a lot of beneficial effects using five ACP with BCX. with patients though, again, you know what, when I'm doing it, I mean, I'm fixing everything diet, lifestyle, gut. So I mean, I mean-
Bernd Friedlander: I know It's also using a lot of collagen your products so
Dr. Justin Marchegiani : and MBC to be six is really important. You can get five HTTP or a lot of these amino acids but be six is really that important cofactor to help with the, the synthesis of a lot of these things. Plus, we know serotonin has a major role also in gut parasitosis gut function is really, really important as well with serotonin.
Bernd Friedlander: Yes, no, I mean, if you use five HTTP correctly, the way you do it, most doctors don't do it correctly, they do too high of a level and they don't have the other things with it. And-
Dr. Justin Marchegiani: Exactly, you need good other, you know, baseline amino acids. And you also have to figure out why the five HTTP is low. To begin with, I mean, I'll test a lot of it the organic acids, so I'll look at a lot of five hydroxyurea last day, which is a precursor to it, or it's a metabolite of it so you can kind of get a window into it. And you have to fix the gut absorption. And a lot of people based on their stress. They have a lot of hydrochloric acid issues and they can't really break down their protein. What's your experience with just people Having poor protein digestion.
Bernd Friedlander: Oh, that's very common. And you mentioned a very important thing B6 and zinc.
Dr. Justin Marchegiani: Very important, very important too. Yep.
Bernd Friedlander: Yeah. And helping with digestion. Another thing also, if you're low in thyroid, you're not producing digestive enzymes, hydrochloric acid as much. And if you're low in thyroid, your metabolism slows down anyway. And if you're not consuming sea salt and ACL, which is a precursor to manufacturing yours, enzymes, it's necessary. Salt is really how it all started this the precursor to all of hydrochloric acid and Pepcid and all that. And nobody really consumes a drink sea salt, pure 100% clean sea salt in water and one teaspoon in the morning and evening seems to help people with low acids.
Dr. Justin Marchegiani: You any my patients who are listening they know I recommend a half a teaspoon to a teaspoon of Redmond's Real Salt or Himalayan Or Celtic salt in the morning. And in the afternoon, I think it's really important and are drinking a really good quality like mineral water. I like to put Chico Pellegrino is also good bosses good, which has a lot of different minerals in there as well, which are super helpful for the building blocks of a lot of the hydrochloric acid. So I hear that it makes sense. Yeah. Tell me a little bit more, what's your elevator pitch on em tour, like, we know, we want it to go down. And we know that protein dropping protein down helps drop it at least in that fasting level. But we also want to have protein. So when we eat protein, we it will spike, but it's kind of more of having a period where we don't, and then a period where we do so we're kind of creating this rebound effect. Can you talk a little bit more about that?
Bernd Friedlander: You know, and tour is very essential in the early stages of life, because up to the age of 25, we need it. It helps to build muscles and helps to stimulate growth factors. So we need that. So that's very important. After a certain age, the tour pathway works differently, it starts helping accumulate other cells to grow as well, you know, abnormal cells, cancer cells, they require this pathway in order, you know, to start stimulating their growth and their, you know, their spread is also done by m tour pathways. So, it's when you have HIF it's, you know, hypoxia, less, you don't have enough oxygen and accumulating in the cell correctly, and it's not being utilized for energy at all. But it takes a different pathway and to lactic acid. So that's the problem we have when tour and lactic acid gets involved together, they seem to go into and stimulate more of abnormal cells and but the tour pathway is controlled by, you know, the types of proteins we accumulate in our body. Whey protein and milk protein and all these other proteins will, will lead to empty your pathway. And one of the research done 20 30 years ago was that if you balance it with a gelatinous food like collagen or gelatin, anything that's gelatinous, it seems to negate them these factors in these proteins so it balances the protein. So when I was working with athletes, for instance, and they were consuming a lot of these amino acids that are trip the famous line 16 in the way products, but they were also having a lot of issues with kidney problems. They were having issues with cardiovascular problems, he's a massive amounts of athletes. So you want to make sure that when you're doing this, you balance these amino acids and the only way I was able to find that was in research was using gelatinous collagen. It seems to balance the negativity effects of the amino acids and it doesn't stimulate em tour and I've seen it with hundreds of my cancer patients when I added college into their diet. They went back and had an MRI done. Some of them still continue doing PET scans, which I don't recommend, but the MRI showed that their cancer cells stop growing and almost went into remission.
Dr. Justin Marchegiani: And so regarding em tour, insulin is going to drive up them tour so too much carbohydrates too much, you know, glucose and we know PET scans are basically giving yourself they're giving you radioactive glucose and they're seeing where it's going because they know the cancer cells are going to take it up. So you're saying on one side, we can decrease some of the protein. The other side we can modulate the carbohydrate in a good range. And then number two is trying to get more collagen based amino acids which aren't going to spike the tour as much. And you also say you can still kind of be more ketogenic while taking collagen too?
Bernd Friedlander: Absolutely because, you know, as you know, ketogenic diets are basically two things high fat and high protein. And that's how you, you know, stimulate the ketogenic factors in the body. So-
Dr. Justin Marchegiani: There'd be some people that would say high fat, but then some people say more moderate protein just because they're trying to modularize glucose, Neo Genesis and some people are talking about the fact that you can increase glucose a little bit just through glucose, Neo Genesis. So is there is there a percent protein that you like for a ketogenic template?
Bernd Friedlander: You know, I've always say that it's again, the amount of energy that you expire, and the type of physical activity you do during the day. So if you're more of a weightlifter or more of a bicyclist or somebody, you're going to need a little more protein than somebody who's not working in extra I feel as much but you want to make sure that you know we found that after age of 60 the requirement for protein is much greater at that age than any other. So you want to make sure when you're over 60 you start consuming more protein and fats. And the problem with fats is you know, fats are very highly unstable and you know, unless you eat saturated fats right but there's also a minimum amount they found that too much fats of even saturated fats can cause problems so you have to know how to control that and you got to take certain antioxidant like vitamin E to help the lipid oxidation factors of NC Yeah, yeah. So the one I found was really good as ghee butter, ghee butter seems to give you more balanced, it has a lot of antioxidants, vitamin E, beta carotene, and it can, it's clarified so it is a different form. fat and it helps accumulate a fast metabolism in the body. And so those MCT oil, you know, using those two will help with facilitate, but you don't want to take too much you want to be in the right ranges. So I think fats are important but don't overdo it with too much because it can cause late on with lip it oxidation, and it doesn't make a difference what form of pats bats because then you have free fatty acids which are signaling factors to aging anyway.
Dr. Justin Marchegiani: And then how to fat burning how does that affect the mitochondria? I've heard that you know glucose kind of as a more dirty are fuel to to kind of burn regarding oxidation and fats a little bit more of a cleaner fuel. I know there's a book by Kristofferson called tripping over the truth, it's about cancer, and he looks at cancer as being a mitochondrial issue. And he talks about fats essentially being one you're not fueling the cancer as well, but you're burning a cleaner fuel source.
Bernd Friedlander: You know, it's interesting with cancer because that's probably one of my more concern and interest in I had more experienced since 1980 and researching cancers anybody else because of my father passed away. It's the Oda Warburg principle where sugar is not the problem. Here, it's the utilization respiratory change the Krebs cycle, the mitochondria. The mitochondria does not use the electrons correctly, it doesn't oxidize glucose correctly. So it takes fat and protein and accumulates those into energy and it goes into glycolysis. And instead of oxidation of glucose, which is the normal Krebs cycle pathway, but everything in the mitochondria and a D plus goes up. When oxidation glucose occurs. When electron donation is properly there is the byproduct the Pyruvic acid is not being converted, right and goes into lactic acid. So it's where if you don't supply the body, enough sugar, the body goes into a different mechanism and utilizes free fatty acids in its energy cycle. And that is the problem with cancer cells. When you accumulate too much for you, fatty acids from protein and from fats it utilizes to break it down energy, but the end component becomes lactic acid instead of co2 and co2 is a major mechanism for respiratory function to convert back to normal function again, and if we don't have enough co2, and that's why high altitude people live longer, and they have less diseases and mortality because they're accumulating much more co2 in their blood. And if we can raise that co2 levels, that's the secret and increase the oxidation of glucose, which is what Warburg says is the key component. And that's where NAD comes into play. And that's how it works more efficiently by using nice cinema, right? Because nice cinema is a precursor to NAD Plus, and it's also inhibits free fatty acids. And so those aspirin, aspirin with baking soda cuna taken together inhibits free fatty acids. So now you're converting the cells back to a normal function of respiration where the end product becomes co2 and water.
Dr. Justin Marchegiani: Right so with our mitochondria we have glycol says which happens outside the cell and then inside the cell that's we start burning glucose and then inside the cell, we start generating all this acetylcholine which starts pumping the Krebs cycle and then the goal of the Krebs cycles we develop or we generate these reducing compounds NADH FADH 2 and then all these hydrogens from That from the reduction that happens, enters into the electron transport chain. And then we generate more ATP during that process, spit out a whole bunch of co2 and the cycle continues. You want to add to that at all?
Bernd Friedlander: Yeah, no, you hit it right on it. And if we can continue that co2 cycle, that's the secret. That's why breathing is important. That's why when swimmers swim, they accumulate more co2 because of their breath holding, you know, they're holding their breath while they're doing strokes. And then they're letting out the breath. And that's a very important co2. If you start taking baking soda, it helps with that too. And when you drink mineral water with CO2, you know anything with carbon dioxide, like Pellegrini mode, or the German one general stole just a minor. Yeah, those are very important because they're accumulating more co2 in your body. And that helps.
Dr. Justin Marchegiani: And let's talk about some of these reducing compounds you've talked about. Improving NAD NADH what are some of the best ways we can actually do it stuff a mentally diet wise lifestyle wise?
Bernd Friedlander: Okay, supplemental. We know that nice [inaudible] does that and it's the cheapest form of improving NADAN live.
Dr. Justin Marchegiani: Yeah, I'm a [inaudible], what do you thoughts about Nigen?
Bernd Friedlander: Nigen is from Chroma DAX I've been using Nigen for several years now I met the company when they started the process of of utilizing milk and they found a component in milk that goes into NR which is the key factor and Nigen does work very well and in some people you know, hundred to 250 a day seems to work very well and I use that myself every day. So I've seen very good results from that. And also I've used [inaudible] blue with the complex for you know, helping with site cider chrome oxidase enzyme which is also a key component to NAD levels going up. And probably the best thing we have in nature and besides some foods like broccoli help with NAD, you know, we know that beer but you know, there's a lot of problems with beer too. And insulin growth factors and all that because accumulation of sugar in that body. But beer has a component in there that helps with energy levels. Most of your fruits and vegetables are very good for that. In general, the best thing we can do is sunlight or red light, sunlight and red light helps with stimulating NAD plus. And I think if we get some sunlight in the morning, from from seven to 11, and then the evening from three to five, three to six, we're getting an ad function
Dr. Justin Marchegiani: and a fats and proteins effect NAD? Does that help because we want that we want these reducing compounds so we can grab all these hydrogens. How does interplay?
Bernd Friedlander: Yeah, we're, there's there's some interesting work being done, where they think that fasting, which I think what it does it, it helps to clean the body out a little bit faster, it helps with the toffee function a little bit better. But NAD is an electron transport mechanism. So any way we can increase electron through these mechanisms of you know, lifestyle and avoiding, you know, blue light, you know, avoiding computers and TV and videos, we're going to increase NAD levels, and fasting and working out. One of the best things in improving mitochondrial function and add is concentric workouts where you do muscles work where you're stimulating resistance, but you're doing it in both fashion where you push, like a push up and then you risk you have resistance going back. So it's called concentric workout. has been shown to be the greatest form of exercise to increase increase NAD levels and mitochondria.
Dr. Justin Marchegiani: So interesting. So would that be more of like a super slow kind of training where young slow, but then you're also resisting on the way back so you're not just dropping it letting gravity to give you a free ride down,
Bernd Friedlander: You're 100% right on that. And that's, you know, the 10 seconds pushing any kind of resistive exercise where you count to 10. And you go down on a count of 10. And any form where you're pushing against something and you push and somebody pushes you against the movement, you're using concentric exercise.
Dr. Justin Marchegiani: And what's your take on some of these bands that are out now some of these really thicker bands, I'm starting to like them because I'm seeing Well number one, and this week or place here or you know, squat where you could get hurt in the detentions last but then as you go further out, it's more and then you also have a lot of things tension on the way back to it and it's like what's your take on bands for some of that stimulate?
Bernd Friedlander: I think bands are utilized correctly are incredible exercise in combination with core exercise, you know, when you do the core at the same times with the band, meaning if you're squatting a little bit and you're using your stomach muscles, you know that squatting, you know, anytime you do a plank, you're using your core muscles or-
Dr. Justin Marchegiani: Some lunges and anytime you're stabilizing your body where you could fall over, you're using that whole entire core.
Bernd Friedlander: If you use the whole entire core, you're getting a greater results on the body in full function and get greater mitochondria function and the repair mechanism increases. Athletes when we used to see athletes with the Raiders, Rams and Lakers. I didn't realize until now what I was doing then. But I realized that when you do concentric exercise, you're actually decreasing the amount of tension to the joint and because of that You are also facilitating healing and mitochondrial function. I think that's the key to the concentric exercises is that you're leaving eating the stress on the joints when you coming after a surgery or bi or having pain or any kind of thing.
Dr. Justin Marchegiani: So essentially what the con centric, everything's slow so that muscles always contracting. So if it's the chest here, and then you're coming back on here, well, now it's going to be the back muscles that are starting to shorten the stage on the way down. So front, concentric on the chest on the way out, and then back. It's going to be more concentric on the way back, right slow.
Bernd Friedlander: Yeah. And when you do a band workout, if you can do a band workout and you put your doctors and you're pushing out, you want to also have it somehow resistance going back in, you know, so you're pushing. So you take your hands, and you know, you do like, push like this and then push out this way, but I'm resisting Celebrate do both ways, you're resisting on both movements. And that is the best way to train a muscle.
Dr. Justin Marchegiani: Excellent. Yeah, I like that. That makes a lot of sense. So regarding the Krebs cycle and NADH, is there any DS or any other let's just summarize. So obviously we have nitrogen we have nice minimized. You mentioned some of the vegetable compounds, right? What other compounds can we do to improve NADH? And then what about FADH? To that that kind of gets ignored? Can we increase FADH to it all? Right, ADH.
Bernd Friedlander: Yeah, we can. And, you know, again, I think a lot of it is the quality of life, you know, is the stress reducing your stress value, having a positive attitude, meditation, all these are, you'd be surprised how the respiratory chain uses all this in the mitochondria improves on all levels. One of the things is when you consume foods like you know Color foods like pulp bell peppers, yellow, green and red. They're very important onions are very important certain fruits like apples have tremendous benefits in that. And if we cook our vegetables specially Aqua ciphers, vegetables and and don't eat them so raw we break down to cellulose which allows for the digestion to improve and assimilate all the nutrients in that vegetable rather than having too much fiber and causing dissension bloating. I think also, you know, we you know, coffee does that to coffee helps with mitochondria stimulation. People don't-
Dr. Justin Marchegiani: Let's talk about that a lot of people think coffee may not be a good thing. I mean, obviously we overdo it and get too much caffeine or we were a slow caffeine metabolize or there may be a problem there, but can you talk about some of the benefits whether it's alkaloids and also some of the mitochondria and anti aging benefits with coffee?
Bernd Friedlander: You know, about 15 20 years ago, I met a fellow Radical pathologists, antioxidant expert. And I met him at Stanford when I was working at Stanford at the ESRI department. And I said what we were talking about antioxidants and free route and he says, you know, the greatest antioxidant food we have today, he mentioned was coffee. Yeah. And coffee is truly an antioxidant, has high antioxidants. But one of the important things about coffee, the caffeine is essential for stimulating blood flow and oxygen to ourselves. It helps if you I learned this when I was working at UCLA with the athletes I learned from a cell physiologist. He says if I take coffee and I take an aspirin in the morning, it will increase my uncoupling protein mechanism meaning I will get greater mitochondrial benefits I will get better electron flow better oxygen to myself. And so I started using coffee and aspirin in the morning with the athletes. And not only that improved their cognitive, but their exercise performance and all of that improved dramatically. So I think all of that is, you know, coffee has magnesium, it helps with oxygen. It helps with caffeine. So you get great a flow of oxygen to the brain. And it's all around probably the best, you know, cognitive drink we have there in nature.
Dr. Justin Marchegiani: Excellent. And then I know what the aspirin that's the Seattle that's the Seattle acetic acid. There are side effects associated with that with alterations and liver issues. Do you feel like the benefits outweigh some of the side effects? Is there a dose issue there? And then also, would you rather use white willow bark or just straight aspirin?
Bernd Friedlander: Well, I've been using aspirin for oh god going back since the late 80s and 90s. So I'd learn basically it's if you have an ulcer it's going to be created by something totally different. Yeah, h pylori, or actually salt deficiency. I've used salt and vitamin E and and getting rid of all the severe ulcers. Yeah. The other thing is aspirin recently came out with a great paper on aspirin shown that it has one of the best mechanisms for a toffee and increasing toffee. So it also helps with try back yellow meaning it helps to stimulate calcium into the bone. So if you're where you're breaking bone down, because every time we work out we don't take enough calcium vitamin D where we're actually using calcium as an excitatory mineral to handle stresses all the stresses in our life so it gets pulled out of bone. Well, aspirin helps with calcium, vitamin D and going back into the bone and keeping the bones From it also has antioxidant components. It helps with platelet function so it prevents platelets from sticking and clotting together. That's a big factor of aspirin. But I tell people if they're going to take aspirin, take a with baking soda, you getting the benefits of the buffering system, you're getting co2 levels and you're getting the benefits of what aspirin does without causing a disturbance or this stress in the body in the colon.
Dr. Justin Marchegiani: Are there any benefits just doing the whole herb that aspirin comes from, which is the white willow bark over the stage?
Bernd Friedlander: I learned this from a veterinarian actually who's working with us in race horses, and they buy the pure aspirin powder in potassium, magnesium is sodium salicylates, you know, yeah, and they use that rather than than YN for the horses and animals. They require so much of it, that they have to buy the huge bulk. So if you can get potassium, sodium magnesium salicylates, that's even better and you've got to go to a pets you know compound or somebody that works with animals then you can order from them and now you're getting greater results.
Dr. Justin Marchegiani: Yeah and then what's your take on the race syndrome that can happen with the aspirin know that can happen when you're younger usually there's a viral infection happening with it. And then so you really want to be careful taking aspirin if there could be a viral infection?
Bernd Friedlander: If it's you know, that's something I have not I've read and looked at research and I have not found a true paper on that. It's the same thing with honey they said if you take honey at a certain age, you know it can contribute to this problem to not seen enough of it, but I you know, for a child, you know, if you're going to give asked me, you want to make sure that child gets very low anyway, extremely under maybe 45 milligrams or less. They don't need much.
Dr. Justin Marchegiani: I'll put in the chat here for you an article on aspirin and [inaudible], basically the big thing is it's just, um, you want to avoid giving aspirin with kids when there could be a viral infection. So in general, just trying to maybe avoid it to begin with until people are older, maybe a good idea. I know people are hearing a lot of the benefits. I just want to make sure they don't jump on board and, and give it to a kid or just to be on the safe side there.
Bernd Friedlander: Absolutely. I agree.
Dr. Justin Marchegiani: Yeah. Well, that's good. I think there's some benefits there. That's excellent. And then what about topically using aspirin? Can you put it in like some DMS or some kind of a lipid normal solution? rub it on the skin of the joints?
Bernd Friedlander: Yes, absolutely. Um, you know, back in the old days, we used to use a lot of that we used to grind the aspirin and then add a little DMSO with it, or anything that our aloe vera anything that helps with driving that in there, you know, essential oils, and it's a great topical, great topical, because it works. You know, aspirin is one of the few molecules that works on Cox one and two. mean in the prostate gland is wanting to every other anti inflammatory only deals with one of them correct one and that's it not with two. So aspirin has a greater potential inflammatory mechanisms in anything else and Buswell of those two as well as the only plant that works on both one and two-
Dr. Justin Marchegiani: Have a curcumin that do both, or?
Bernd Friedlander: No, Curcumin doesn't work on both only Buswell in nature it was done by a lot of scientific studies done at the University of Florida, Florida AMM by Elizabeth Mazzeo, MA VIO.
Dr. Justin Marchegiani: Excellent, very good. So what other things can we do to help improve mitochondrial function or just improve longevity in general, you mentioned the aspirin you mentioned the coffee compounds, obviously, you like adding fat and collagen to the coffee which I think is even better, because you kind of time release any of the stimulation that you get from there which is nice. Anything else you want to highlight?
Bernd Friedlander: Yeah. You know, looking at foods like pasture raised eggs is important I acute, you know, we do need protein, there's no way a vegan is going to survive long term results. You know, most of the people that I reviewed that live 90 to 100 years old and I did a paper back in the 90s or 80s at UCLA, and I found that the people I interview, they were outgoing, they had a positive attitude. They were in sunlight all the time. They were never indoors. They took walks, they never exercise, but they took walks, they ate really well. They had a great breakfast, all of them. I remember telling me about there was 250 people that we interviewed that were 95 Plus, and they all had a good meal with protein. You know they ate cleaner there because they were from different areas where everything was fresh, you know, they could get it from organic farmers. There was no spraying that that time so they ate everything. Anything with grass fed beef, lamb, you know, black cod shrimp. You know, white fish is much better than salmon. There's less oils in this in these fish, so you're not accumulating so much omega threes. So a lot of that and also, breathing exercise correctly getting sunlight and sleep. We got to get quality sleep. And I think the most important thing is at night, get away from your computer's TV. You can watch some TV but no cell phones, no, you know, anything that has an EMR effect on you because you need to lower the frequency of the brain to from 0.5 hertz to 12 hertz at night. That's the frequency of the brain at night and that's everything we work with. It's in gigahertz and megahertz. So we're over stimulating the cell so I think relaxation at night putting using, you know, red, orange blue lens glasses at night to keep the filter the blue light out of the blue line. You know, that's the secret, I think more in nature and condensing and eating right? Eat your vegetables and fruits cut back on your carbs, no doubt about it, your grains in your nuts. Those are the way I would do in law in order to live longer and, you know, less illness. And, you know, the thing is, we're not going to extend the lifespan like some people think 220 30 we're not genetically designed yet for that, you know, that may happen when we start accumulating with stem cells and we inject stem cells in our body. But right now, we don't want to have diabetes, heart disease, arthritis, you know, all these things that come up. Now, even at young people at 40 and 50, where it used to be some 60s and 70s and 80s. Now it's starting to show up earlier.
Dr. Justin Marchegiani: Interesting. Now you talked about red light there any red light devices that you Like I know you're in sunny california but most people parts of the world's getting pretty cold and not quite possible to get outside. What are some good red light devices red light options this time of year.
Bernd Friedlander: Um, I've discovered from Europe a you know some light devices that I purchased for Matthew cook who's an MD who's one of the premier stem cell fellows in in the Bay Area in Los Gatos and we're using these panel of lights which produce led red and infrared at 600 watts and then 45 watts and at 24 one so we have different watch. And I have them I have the person and patient just stand in front of it and look into it and that also helps with thyroid and FB. Every day I use it myself over my stomach. I think that's the key because anyway you shine the red and infrared light It helps to facilitate more oxygen mitochondria function. It helps with cider chrome oxidase enzyme, which is the key enzyme which we know is essential to all living systems in our body. All the photosynthesis occurs with cytochrome oxidase enzyme. All the NAD occurs with cider chrome oxidase enzyme and that is found in the 600 to 800 nanometers range and that's what we want to increase. So using it, I use it every single day and morning and evening before I go out, and at night before I go to bed, I I stimulate all my joints that I utilize the most my my stomach and I do a little thyroid. I treat my thyroid every day in the morning evening.
Dr. Justin Marchegiani: Interesting and using red light for all that that's cool.
Bernd Friedlander: Yeah, we'll be you know, we'll I'll send you a picture of the design we're working with and I think you'll like it. It's something I just brought in about 50 to 100 have mostly empties using it right now because they're using it for stem cells. And they're seeing they're increasing stem cell production with it.
Dr. Justin Marchegiani: Excellent. So red light helps to improve themselves production. And what's your take on stem cells in general? Obviously there's different kinds right. And some people are doing it topically some people you know, where they're injecting it in specific areas. Some are just doing it systematically be an IV, some are going down, I think Panama's the big hotspot. I think Dallas and Seattle have a couple of areas where you can get it done. What's your take on stem cells?
Bernd Friedlander: Well, I've been doing some stem cells on myself mainly for an injury that I accumulate, playing professional soccer and running and you know, training athletes from my hip. It helps there's no doubt, you know, platelet rich blood. Blood PRP. Yeah, PRP is very important. It helps to bring down inflammation it stimulates you the production of your own stem cells. There's no doubt on shoulder and knees, it works phenomenal. I've seen results with no surgeries required for the shoulder and for the knee. We're working on the hip area and it definitely helps improve the quality of life. I think some serious diseases, neurologic neurological diseases, I think even MS and Parkinson's, I think it's got great opportunity, I think we're going to see some great results with it. There's different stem cells coming from the, you know, different tissue placenta, you know, from the skin, adipose, bone marrow, those have different functions in the body. And I think you're going to see more and more of this out there. And especially in sports, you're seeing more professional athletes gravitating towards stem cells today, in less surgery.
Dr. Justin Marchegiani: Oh, absolutely. Because as soon as you go get surgery and you start tearing through tissue, tissue becomes a little bit weaker, you're more prone to injury in the future. Also just, you know, the fact that you're talking about people that have to twitch their muscles and move with such fast level that they lose just a couple of milliseconds off after moves. They could take them out of the professional sport level. So for sure, that totally makes sense. I see stem cells, probably putting a large chunk of surgeons out of business, I just think you're not going to need surgery for the more chronic wear and tear stuff, I think you'll be able to come in there with diet, lifestyle, supplementation and stem cell. So it'll be really interesting to see how, you know, things evolve over the next couple decades.
Bernd Friedlander: Yes, I think also for ligaments and tendons, it's got greater benefits too.
Dr. Justin Marchegiani: And I think, you know, the biggest issue is people are still going to use stem cells and forget all the diet things, forget all the lifestyle things and use it as triage. I think when you combine it with the collagen, with a good diet with good lifestyle with the light stimulation, right, all the mitochondrial things we talked about today, I think you really have a greater chance of supercharge in your healing.
Bernd Friedlander: Absolutely. And even the people that the MDS that are doing stem cells, they want you on an anti inflammatory diet, first of all, you know, in order for this to work they want you to accumulate. And most of these stem cell clinics, it's interesting there are using college and now and they have seen better results. They actually prep the person with college and before they come in, and when they take their own adipose tissue placenta, wherever they get it from. They see a better production of stem cells coming out of those people with consuming collagen prior to having stem cells.
Dr. Justin Marchegiani: Interesting. Yeah, really fascinating. What other things do you recommend? Is there anything else that you wanted to highlight that you think is important for the listeners to know about?
Bernd Friedlander: Again, I think a lot of it is the attitude positive attitude we have every day and look good life and help others you know Don't stress yourself out, don't have negativity but look in the mirror every day and just say I love myself I love everything about me I look great. And then start the day with you know, doing the right things red light, sunlight, collagen, breathing exercise, concentric exercises, you know, don't you don't need to go and do a robotic exercise like hours a day. That's oxidative damage. I think walking throughout the day is very important. accumulating the right proteins, you know, grass fed and all these, you know, things that are natural to us. And eating right. And you know, we don't need to consume as much we don't need big plates, we need small food. And there's been studies that if you feed the body with small meals throughout the day, you increase the thermogenic function of the mitochondria, you're stimulating the mitochondria to burn more fuel more efficiently and And all of that and then eliminating the stressors, you know, like, being on Wi Fi videos, cell phones, you know, don't use them as much and, and and use more natural light at night because night darkness is a stressor to our body. That's it. That's when cortisol goes up. So we want to keep that down. So take, you know, vitamin D and take an aspirin with baking soda night. Take anti inflammatories at night, you know, that seems to work the best.
Dr. Justin Marchegiani: Right? I think I think it's the opposite. I mean, cortisol is dropping at night because melatonin goes up cortisol drops, cortisol comes up in the morning and then down at night.
Bernd Friedlander: Yeah, yeah. But yeah, and then cortisol suppresses melatonin. Exactly.
Dr. Justin Marchegiani: Yeah. So as melatonin goes up when you sleep, right, that's going to help. Yeah, some of that repairing. That makes a lot of sense. What is your supplement regimen look like?
Bernd Friedlander: Again, in the morning, I start with an over easy passionate projects. Yeah, ES I take 30 grams of collagen with vitamin C, magnesium, and I take my and our true nature, you know, which is nitrogen. I take vitamin E, not vitamin E I take that at night, and I take a good because likes in the morning I have to end and then that's pretty much it and then at night I do again another regimen of collagen with minerals I make sure my calcium magnesium, vitamin D, vitamin K levels are high. So I do that at night with vitamin D and I take every single night and aspirin and sometimes I'll take tomorrow, but not all the time.
Dr. Justin Marchegiani: Interesting. Very good. Excellent. Well, you have given us some great knowledge bombs here. I really appreciate it. Any last thing you want to leave with listeners.
Bernd Friedlander: I think you know I think what we need to look at I think a lot of it. I see a trend where people are starting to consume like soy milk Almond milk which are okay soy milk is not good because of the estrogen and raising estrogen. And we haven't even spoke about how bad estrogen is. Estrogen contributes to lowering thyroid function and suppressing NADNAD molecules in our mitochondria gets suppressed by estrogen of all the hormones that's why you need you know, progesterone pregnant one testosterone to raise NAD levels. So interesting estrogen down and we need to accumulate a less boost in that area. And I think a lot of the consumption what people are doing today with these soy milk and also almond, you know is a and keeping very important, keep the phosphorus levels down and keep the calcium levels up. There's a gene called Klotho. KLOTHO is a gene I've studied for 25 years. It's now making a difference. Tremendous regeneration of its you know, research on this shown that it controls aging and diseases and growth though is controlled by vitamin D, vitamin K and calcium and keeping a good thyroid and parathyroid, thyroid functioning and consume less phosphorus foods and you're nuts a very high and phosphorus and some of the grains are very high. So we want to make more calcium in our diet. We're not getting enough calcium. People think these these books out there by Tom levy that calcium is bad, actually the opposite. I have worked with a fellow at Stony Brook who reversed his own cancer, pancreatic cancer and hundreds of other people with cancer with increasing calcium in levels that most people won't even look at.
Dr. Justin Marchegiani: His affirmation has enough vitamin K though that higher amount of calcium right?
Bernd Friedlander: We need vitamin K and we get it from kale. If we cook the kale, the juice of the Kale has a tremendous amount of vitamin K. And there's a lot of cheeses out there like Gouda has vitamin K, and especially-
Dr. Justin Marchegiani: You'll probably get it in your GI in the morning as well that you're mixing your coffee. Right, right. And then the big sources for your Vita for your calcium are obviously going to be maybe some of that cheese as well. Some of the butter and energy and also some of your green vegetables and if you eat any fish that have any, any bones in there, what else would you be getting calcium from?
Bernd Friedlander: Oh, some leafy greens and things like that. But I think the greatest any dairy products have the greatest levels of calcium. There's no doubt about if you can handle dairy, dairy products from sheep or goat on raw milk. I think that's where you're going to get the best calcium. Yeah, yes, assimilate the protein helps the calcium go in more assimilated.
Dr. Justin Marchegiani: Because we don't want calcium plaque forming in the arteries so that vitamin K really helps it go back into the bone. So vitamin K into the bone. parathyroid takes it out of the bone and brings it back into the bloodstreams that vitamin K i think is important, and also enough magnesium along with calcium too, because those kind of kind of going back and forth, right?
Bernd Friedlander: Yes, you need both of them.
Dr. Justin Marchegiani: Yeah, absolutely makes sense. Well, you've given us some great information here today. I really appreciate everything. Is there anything else you want to leave listeners with that we had everything?
Bernd Friedlander: I think we had everything I think, you know, I think just like I said, is start realizing that we can, you know, Google and find a lot of information don't rely just on doctors or even myself, read about what's really the chemistry of life. And that's what I did. I went back and I wanted to find out who Justin is and who Bernd and who Lisa's who we are and how this plan came about. And learning about the chemistry of life is the secret to everything that we're talking about today. It's photosynthesis, the sunlight, sea salt, the water, the distance of the Sun and the planet Earth. Earth and, and the amino acids and the sugar complex that created all life. And when I went back and studied, you know, 200,000 years ago, 4 billion years ago, when the 2 billion years ago we had a, an organ LO bacteria called the mitochondria, when the mitochondria started developing in a planet Earth, that's when every living system started being created everything from fish, the animals, reptiles to certain plants and life itself. And how did this bacteria get here was the key and understanding how this key and this organelles develop, I think gave me a better view of what we need to do in ourselves to maintain that organelles, that organelles we need to maintain.
Dr. Justin Marchegiani: I love it. Dr. Bernd, thank you for all the feedback and little tidbits and advice here really appreciate it. Great chatting with you all and we'll put burns information down below so if you want to reach out to him, you'll have all his information down below. Excellent, great shout out to burn you have a phenomenal day. We'll talk soon.
Bernd Friedlander: Okay. Thank you Dr. You're wonderful.
Dr. Justin Marchegiani: Thank you. Have a great day.