In this in-depth conversation, Dr. Justin Marchegiani and Evan Brand break down why chronic inflammation persists and why symptom-suppressing approaches fail. They explain how inflammation affects the joints, brain, gut, mood, and energy, and why identifying root causes is essential. Unlike acute, helpful inflammation, chronic low-grade inflammation is driven by ongoing immune triggers such as toxins, infections, gut dysfunction, and poor diet, leading to pain, brain fog, fatigue, and long-term tissue damage.
Core Causes of Chronic Inflammation
Key Takeaway
There is no magic pill for chronic inflammation. Real healing requires a multi-factorial, personalized approach that addresses diet, gut health, infections, environmental toxins, nutrient status, movement, and recovery together. Functional medicine testing and individualized protocols are essential for lasting results.
Dr. Justin Marchegiani: [00:00:00] Hey guys, it's Dr. Justin Marjani. Welcome to the Beyond Wellness Radio podcast. Feel free and head over to justin health.com. We have all of our podcast transcriptions there, as well as video series on different health topics ranging from thyroid to hormones, ketogenic diets, and gluten. While you're there, you can also schedule a consult with myself, Dr.
Jay, and or our colleagues and staff
to help dive into any pressing health issues you really wanna get to the root cause on. Again, if you enjoy the podcast, feel free and share the information with friends or family. And enjoy the show.
Hey guys, Dr. Justin Marchegiani here today here with Evan Brand. We're gonna be talking about the top causes of chronic inflammation, whether it's inflammation in your joints, manifesting as pain, inflammation in your brain, manifesting as mood issues or brain fog, inflammation in your gut, which could be manifesting as mood issues, energy issues, or motility issues.
So excited to dive in on this topic today, Evan. How we doing man? And early Merry Christmas to you. How you doing
Evan Brand: my friend? Yeah, you too man. Merry Christmas to you and your family. Doing well and yeah, this is huge. I've dealt with this [00:01:00] crap, so I love sharing the personal stories 'cause people know that, there's a million clinicians out there talking, but when you've had personal experience, it's the best teacher.
And I remember waking up just feeling stiff. My hands would be stiff, my knees would be stiff, my hips would be stiff. I had several tick bites. I had mold exposure. These infections and toxins will drive inflammation even in a young person, even in someone who quote is too young to have these issues. It's it. It's a big problem and it's reversible, but you gotta know what you're up against. And so if you just go to the conventional doc and they give you a cortisone shot, or you go to, let's say your GP and you get, I don't know, ibuprofen, I don't even know what they're doing, but it's not root cause. A
Dr. Justin Marchegiani: hundred percent.
So first off, let's go and actually define inflammation. I think most people like, it's like you know it when you feel it, right? But what is it? So essentially your body metabolically has this anabolic right growth phase where it's rebuilding and healing and then it has this [00:02:00] catabolic like breakdown phase.
And you wanna be catabolic at some standpoint. Going to the gym is catabolic, like just living your life is catabolic, but your body. Hopefully builds back up 'cause you have enough rest, enough good growth, hormone testosterone, healthy thyroid hormone, you have enough protein, amino acids, building blocks coming in, so you build your body back up stronger.
And so inflammation, especially of the chronic type, let's say acute inflammation. Everyone knows that you go to the gym, you do some bicep curls the next day or two days later, you're sore, right? That's inflammation. But there's a hormetic effect, meaning your body gets a little inflamed and then layers a little bit of muscle back, and then you have hypertrophy happening and then you're stronger.
But the chronic inflammation is this low grade level of. Cytokines Interleukins, TNF, Alta Alpha Nuclear Factor Kappa Beta, right? These are inflammatory compounds that start to just hang out at a lower grade kind of chronic level. They don't just acutely go up and down. They start to hang out longer and longer.
And of course certain foods can drive that. Whether it's omega six processed vegetable oils that are oxidized, [00:03:00] whether it's sugar or excess insulin, too much carbohydrates. Food allergens can be a big one. That can be a inflammation on steroids. 'cause if you have any autoimmunity, gluten processed dairy.
Processed seed oils, processed flowers, things that are laden with glyphosate are going to increase your chance of having more food allergens because glyphosate makes your gut more permeable, which then makes that processed flour. 'cause it's mostly flour and soy and omega six oils that are gonna be loaded with glyphosate, right?
Those are the processed foods. So that makes your gut more permeable and when your gut's more permeable, whatever that food you're eating with that permeability factor makes those allergens go up.
Evan Brand: Yeah, this is huge. And let's bring in mast cell activation and histamine tolerance. I love that you brought up these inflammatory cytokines.
So your mast cells, yes, they produce histamine, but they also produce tryptase and so many other inflammatory mediators. Meaning if you've had long haul syndrome from the virus, if you've had an injection re reaction, that's a big deal. And you could be dealing with a long-term issue related to those bugs keeping your immune system in a [00:04:00] hypervigilant state.
And using nutrients like cetin, Perea leaf to calm down the mast cells is sometimes very important to heal from this inflammation. And for me, the inflammation would hit my head. I'd feel this head squeezing, almost like my head was in a vice, and it's certainly gotten better, but when the mast cells were flared up, I could feel it.
Dr. Justin Marchegiani: 110%. That's a totally true thing. Mast cells and histamine, that can be a thing in the inflammatory bucket, but it's usually when the inflammation is already full, the body is stressed, the. There's a lot of times it's the immune system is reacting to the inflammation. It's reacting to the mold in the environment or the mycotoxins in the home, or it's reacting to the dysbiosis that's in your gut, that's producing histamine, and then your histamine bucket starts to get full.
And then if you add in a crummy diet. Or even just some higher histamine foods, that could be enough. And people talk about histamine, like it's the cause. It's a downstream effect of a lot of other upstream issues too. Yeah. And then we could also add in some co-infections. We talked [00:05:00] about Lyme last week, right?
The great mimicker is your issues caused by ly or co-infections. And that could be another issue as well is you run a lot of DNA connection tests and you see some of these microbes coming out at higher levels in the urine. And so it's always good to look at that. It may not be the big thing or the thing, but it may be a thing in the background.
It's kinda Hey, your computer's running okay, but you got this big like hog of a program in the background, taking a lot of memory, it's good, but if you like go in and you go to control panel and you end task, it's whoa, my computer's really fast. It's like that. It may not be the thing or the maybe a thing.
Evan Brand: Yeah, I had a lady last week in Florida and just, she had some weird symptoms and so I thought, let's just look. She didn't have a history of tick bites, but I thought, you know what? This sounds weird. She's got chronic inflammation. She's in her fifties, so she's not so old where we expect that level of inflammation and joint pain.
She had dizziness, which was the real kicker for me, and so I go, you know what? Let's get this DNA test done, and then boom, she's got Babesia. And so Babesia is an intracellular parasite. It lives in your red blood cells, and Babesia is a beast. I've got other words that [00:06:00] start with B for babe. Because I've had it and it's not fun.
And I had, my story, I had dizziness, I had head pressure, I had blurry vision. So Babesia could be a real problem for immunocompromised people. And so luckily we're getting on, we're getting some herbs for Babesia in her protocol now, and she's gonna do better. But this is huge because. She was previously living in a house very close to the beach, 1950s house, tons of mold.
So we thought, okay, mold is driving the inflammation. When she got out of the house, the inflammation got better, but she was still stuck with this dizziness and head pressure. And that's where a provider is gonna help you to dig deeper. Because if you just Google this stuff, you're not gonna know. Where do I go next?
Okay. We extracted as much data as we can from the OAT test to find the mold, fix the mold got out of the. Now she still has these symptoms. So now what? And that's where you gotta be able to dig deeper and go, okay, look, now we found Babesia, let's pursue that. So when you're talking inflammation, when you're talking joint pain, I saw this video a couple years ago of a bunch of crippled people at Disney and the caption [00:07:00] said like, why is everyone at Disney crippled?
And it just cut to all these different people with braces and shoulder straps and knee braces and this is a global issue. The combination of, as you mentioned, these food allergens disrupting the gut barrier, creating nutrient deficiencies and internal inflammation combined with everyone's inside.
Correct. Our ancestors, your grandpa, my grandpa, they grew up more outdoors than now and a generation further, 95% agrarian society. Now we're inside these tight buildings. So everything happened so quick and then combine that with. Infections from Lyme, Bartonella, Babesia. With the mold. With the gut. You see how this thing spirals outta control?
Dr. Justin Marchegiani: It does. It really does. And then when you look at like inflammation too, inflammation's gonna decrease some of the capillaries that go to the joints, that go to the cartilage. And so then you're gonna have less blood flow, you're gonna have less building blocks to help repair. Those joints and where they articulate and where they bend essentially.
And then also, if we have not enough protein coming into our body, proteins are really important. Building block, [00:08:00] not just for our muscle. Everyone knows protein and muscle. People don't realize your bones are actually high protein. Okay? And so then if you have low hydrolic acid and low enzymes, or we're not breaking down, you know the protein we have h pylori and we have a couple of parasite infections, then.
Then now there's a bottleneck in the protein. Maybe we're stressed, maybe we're not making enough hydrochloric acid also. Our culture has shifted more to muscle meat and we're not consuming enough skin and bone broth and getting the bones in there. And so we're not getting enough of that collagen building block.
And that's also a big deal is cultures always used to consume collagen. That they eat head to tail, so to speak. And then we're missing a lot of those important collagen amino acids.
Evan Brand: Yeah. That's amazing. What about the nutrient deficiencies that are coming from h Pyl? Lri? That plays into this too, because if stomach acid is down.
People that are eating well, a lot of people that reach out to you and I, they've already got diet pretty dialed in. They've been listening to us in some cases for literally a decade. They go, Hey, man, I've done everything on the diet front. Why am I still achy and sore? And then we look at their nutrient levels and they're low.
And I'm like, holy smokes. You're eating a ribeye for [00:09:00] dinner. Awesome. But man, you are not what you eat. You are what you digest, absorb, and assimilate. So please, if you're listening and you're like, yeah, but Dr. J, I've already done the diet. Why? Why? Why? The gut is the place we're gonna look first.
Dr. Justin Marchegiani: Yeah. And sometimes people I see, we look at some of their, they're not taking digestive support, or if they are, it's two to 500 milligrams.
I'm like let's try two to three grams HCL, let's go a little bit higher. Obviously we're doing it slow and we're careful. And if we have gastritis or history of ulcer, you wanna work with a functional medicine doc, you wanna make sure you worked on the gut barrier and got the gut inflammation better.
'cause anytime there's inflammation in the gut, it's going to. Transition into the body because inflammation in the gut means permeability in the gut. Permeability means it's gonna have a free ride throughout the body and eventually get through the blood-brain barrier in the brain. And inflammation in the brain means brain fog.
It means cognitive deficits. It means let's quick on your feet. It also means, just increased risk for Alzheimer's and dementia and mood issues. Yep.
Evan Brand: I wanna look at this with you. Yeah, we'd have to Google these names 'cause like all the [00:10:00] prescriptions are like just weird names. This is the forecast of the top 10 bestselling drugs in 2025, and this is in billion.
So Keytruda is number 1, 22 $0.2 billion. And this is an immunotherapy drug.
Dr. Justin Marchegiani: I know Eliquis, next Eliquis is the clotting factor, right? They, that's like the newer one they use over Coumadin or Warfarin, right? Yeah. And so Eliquis is one of those. And so well think about blood thinners. What's the reason people need blood thinners for, because they're clotting.
Why? Why are people more prone to clotting? Because there's inflammation, right? Inflammation drives the cells to get more sticky and aggregate and sit together.
Evan Brand: Yeah. Revlimid, you've got immune modulator.
Dr. Justin Marchegiani: Inflammation. Inflammation.
Evan Brand: Yep. You got, look, let's look this other up. Ovo. That one is anti-cancer immune inhibitor.
Okay. So once again, more immune stuff. Brca, let's see that one. Cancer. Cancer. Cancer. Cancer. Man, they, these things are just,
Dr. Justin Marchegiani: [00:11:00] Humira is a biologic. Yeah, autoimmune stuff. Mean all these new names and a lot of times I know I can even medications. A lot of them are, they're just mini mes. They're just other types of.
Medications that are already there and they just flip an isomer around and just, change the profile a little bit so they can get a new seven year patent. That's a lot of it. But when you understand the mechanism of these drugs so for instance, you look at a lot of the memory drugs, people that have a.
Chronic brain inflammation, they're gonna potentially be at risk for Alzheimer's dementia, especially chronically high insulin, right? A lot of that on a Alzheimer's dementia is been known in the literature 15 years as type three diabetes because there's a lot of blood sugar insulin regulation problems, the insulin degrading enzyme that's really important for degrading insulin, also cleans up the plaque in the brain, but.
When you're too busy cleaning up insulin from your processed diet, there's not enough reserves for it to clean up your brain. But when you look at a lot of the Alzheimer's and dementia medications, there are acetylcholinesterase inhibitors. What does that mean? They take acetylcholine and they let it [00:12:00] hang up between the pre and post synaptic neuron.
What does acetylcholine come from? It comes from proteins. It comes from healthy fats, and so we actually have to work on the building blocks. Making sure we're eating enough and we're absorbing enough because the medications just help change the location of where it hangs out in the synapse, but it does nothing to get more of it up there, to get more like absolute raw amount.
It just changes the percentage of where it's located in the neuron. The problem with that is the longer it hangs up in the pre and postsynaptic neuron in this no man's land, the faster it gets degraded and broken down.
Evan Brand: And there's way more profit in that versus a dozen of eggs correct. There you go.
Why eat eggs? That's why when you could just take this drug.
Dr. Justin Marchegiani: Yeah, that's why, there's studies dealt with kids. Having one egg a day increases their IQ by 10 points. My kids sometimes in the morning won't want to eat sometimes, or they'll wanna eat lighter. And so I've been taking like my beef protein or my collagen protein and throwing a whole raw egg in there, organic raw egg, he doesn't even know, but I'm like, get an egg in.
Evan Brand: That's smart, that's
Dr. Justin Marchegiani: [00:13:00] smarts.
Evan Brand: So we hit a little bit of the labs. We glazed over some and tossed them in here and there. So just to make it clear for folks listening, if you have chronic inflammation, pain, headaches, dizziness, joint issues, we wanna do GI to look at your gut. We wanna do an oat to look for fungal infections, yeast nutrient deficiencies.
We may wanna look at hormones, as you alluded to in the beginning. We may wanna look for Lyme and co-infections to look for these. Other triggers of mast cell activation and inflammatory cytokines. And then in terms of quick fixes, things you can do right out of the gate that don't involve pharmaceuticals, ginger.
Boswellia, turmeric. These are easy things. They're systemic enzymes. Eptide, there's lumbo bingo. There's a bunch of these that help. And I tell you, this is with personal experience. I no longer have pain. My hands used to hurt bad. I think when I first had Lyme and the mold, that combo really met to make a fist would hurt.
And you'd say, oh, you're too young for that. No, I'm telling you it was painful and now it's better. So if I can heal from this, you guys can too.
Dr. Justin Marchegiani: And also I have a. A class three B medical laser. I'll use different red light [00:14:00] therapies and infrared wavelength therapies. I was having my keto coffee this morning.
I was sitting down and I played like pickleball like six to eight hours this weekend. So yeah, I'm sprinting stopping. So I was a little bit tight in some areas. So I had the laser on my Achilles for 30 minutes, then I moved it to my shoulder. And and then my knees just to get the inflammation down so I'm not taking aspirin or whatever.
And I'm feeling great, feeling really good. That's
Evan Brand: cool.
Dr. Justin Marchegiani: The more you beat up on yourself, the recovery time as you get older is a little bit slower. So you gotta be more on point, with your food and your sleep and rest to really balance out that catabolic breakdown, you gotta bring in those good anabolic routines.
Evan Brand: Yeah, and it's all something that can be improved. If you're sedentary thirties, forties, fifties, you're sedentary. Now, I promise you, I know that initially to get that umph and that willpower going to get more physical is hard. But I promise you it is like a snowball effect. I notice for myself if I'm swimming, if I'm biking, if I'm hiking, if I'm staying active.
Overall, there's less inflammation even after intense exercise. But if you go from nothing to something, it's like you feel like you're dead. So I encourage you to [00:15:00] build up that exercise callous, if you will, build up that resistance to it. And you and I have talked about row machines, so if it's a row machine, you need to do, if it's a bike, if you live in a climate where the weather sucks in the winter air, yeah, the airbike that, that's an amazing option.
Even if you don't have a ton of space, an air bike or a row machine could be stowed pretty small if you don't have a ton of space.
Dr. Justin Marchegiani: I got two of those right back here and it's great 'cause you're not pounding your joints, but you're still getting the heart beating, you're still getting into that zone four, zone five level.
You're still getting a nice growth hormone bump, right? This is all good and it's not taking a lot of time, so it's way easier to be compliant on it.
Evan Brand: Yeah. And if you're suffering though and you're like, Hey, I can't get the mental MPH to do this, that's where we're gonna look at brain chemistry. We're gonna look at neurotransmitters, because if you have low dopamine, the drive, the motivation, that's where we get this, is from brain chemistry.
And that can all be disrupted if you have dysbiosis in your gut. So once again, now we're con connecting. Why can't you get on the row machine for five or 10 minutes? It's because something is happening. Likely in the gut brain axis. So that's why we're gonna investigate with the urine use amino acids to rebuild the [00:16:00] brain chemistry to where all of a sudden you go, you know what?
That machine looks pretty attractive right now. I think I'm gonna sit down and hit it for five, 10 minutes.
Dr. Justin Marchegiani: Yeah. And also just to reframe take your phone. Okay, great. You're gonna put your Netflix on and you're gonna do zone two, and you're gonna watch your favorite show on Netflix. While you do it that way, you just forget you're even there, right?
Zone two is just at a level where you can just still have a conversation with someone next to you, but not much higher, and it's not too super intense. You can just go put on a Netflix show while you're doing it, and then you're killing two birds with one stone. So people complain about time. It's you're probably watching an hour or TV anyway.
Why don't you do some of that while you do some of that and just kill two birds with one stone?
Evan Brand: Yeah. Isn't it amazing to think just how short ago in human history, this level of exercise was built into farming, built into hunting and gathering, and now we have to have a special building, a special machine for it?
But this is what we were always doing. It just modern life makes it to where it's optional now.
Dr. Justin Marchegiani: Yeah, just think about what it used to be like to do the household laundry a hundred years ago. It'd be like a half a day affair.
Evan Brand: It's
Dr. Justin Marchegiani: a lot of labor washing board out ground. Oh, it's a ton of [00:17:00] labor and now it's like I got the AI sensors.
It knows when it's dry, it keeps on going. It's amazing.
Evan Brand: Yeah,
Dr. Justin Marchegiani: it can soak it for an hour or two. It's okay, that was all manual labor. Hard work. Now it's so much easier. But yeah, so we just have to be very intentional about putting good habits in to override, the convenience of today's modern society.
Evan Brand: Yeah. Said. It's
Dr. Justin Marchegiani: really important.
Evan Brand: Well said. Any
Dr. Justin Marchegiani: other sentiments you wanted to highlight or lab stuff you wanted to highlight?
Evan Brand: Yeah BPC 1 57 is something that, that has been helpful. There's oral versions that work well. I know there's some controversy about injectables versus oral. I've seen great success with the orals now.
There's still people complaining about long-term studies and all of that. Yes. I mean we always need more research on this stuff. We need research on herbs still, but there's just not that much money in it. When things aren't under patent, as you talk about this idea all the time, when things are able to have a patent, there's much more profitability and all of that.
So a non patented formula, there's gonna be less research 'cause there's less profit. And yeah, I mean there are some papers on it, but clinically, we're seeing good success with the BPC. It certainly [00:18:00] helped my shoulder, so I personally love it. It is something that generally cycling on cycling off makes sense.
Dr. Justin Marchegiani: Yeah. And a lot of these things it can't be patented if it's natural. So the more natural something is, you can't patent it. You can't patent NAC really? You can't patent vitamin C. You can't patent some of these systemic enzymes. So that's the problem with a lot of it. So you're not gonna see mainstream drug companies ever push these things out.
That's just the way it is. And so when you think oh, if it was so good, why doesn't Merck or Pfizer come out with it? It's Well because it's not patentable, right? So you have to understand that a lot of modern day. I actually spoke with an organic chemist organic chemist at one of the big drug companies, and I asked him, I said, so is it true that a lot of the drug cancer research, they're looking at a lot of isomers from a lot of natural herbal compounds to see if they can extract a chemical compound to make something, make a drug out of it?
He's he said, I do that. We are looking at curcumin. We look at all these different things. We look at missile toe and we try to see if we can get active components and then concentrate it. And so a lot of [00:19:00] things that they try to actually make, drugs off of actually tend to come from natural compounds.
They just have to isolate and make it their new version of it. 'cause it's, they can't patent nature.
Evan Brand: Wow. Incredible. It makes sense. Yeah. Missile toe's. Great. I did a book a book podcast interview, I guess we'll call it, about a book called The Missile Toe Book. So if you guys wanna look it up, Evan Brand Missile Toe.
You can check it out. It was with, forget the name of the author. They co-wrote it with a couple other doctors. Anyway, it's all about injectable, primarily injectable missile toe for various types of cancer. There's different ones for different cancers. So it's a whole tangent, but for example. I think it was like a pear, like a p like a missile toe that grows in a pear tree.
Could be for breast cancer, whereas missile toe that grows in an apple tree could be for prostate. So there's different ones. There's different types of missile toe and they extract different compounds from different trees and plants that the missile toe itself grows in. 'cause missile toe's, like a parasite.
So we could do a whole like. Missile toe show. If you guys want, let us know in the comments. But overall, get your labs done. Try some of these systemic enzymes, turmeric, ginger, [00:20:00] boswellia. Get the mast cells quieted down. Make sure if you have a long haul syndrome that you're working with a, like a frontline doctor to, to use some protocols for some compounds there to get that stuff under control.
And you really just, you have to. You gotta be ruthless about your environment. If you're living in mold, you've gotta try to improve that, even if it's something like burning some mold candles, using a fog machine. Whatever you can do to improve environment, because if you're currently living in mold, you're inhaling these inflammatory compounds that are gonna piss off your immune system, right?
And so if you expect to get fully better, I don't care like what kind of smoothie you drink, if you have. Water damage. You gotta try to make it better. This stuff will make you spin your wheels, I promise.
Dr. Justin Marchegiani: And there was a compound that begins with the letter I that was really big during COVID that we couldn't really talk about.
That compound's actually now over the counter in Texas now as of last week.
Evan Brand: That's so cool. I take it once a week. So on Sunday, I take it on Sundays, usually once a week. Some Sometimes. You doing 12 milligrams?
Dr. Justin Marchegiani: Yeah. 12 milligrams.
Evan Brand: Yeah. I'm doing 12.
Dr. Justin Marchegiani: Yep.
Evan Brand: Yeah, unless I'm feeling really off, then I'll go for 24.
But [00:21:00] yeah, usually just a one 12 milligram and that really helps. Yeah, there's some limited research on Lyme and Babesia also being hit with it. Yeah, so that's why I'm using it as well. It just keeps things under control for me.
Dr. Justin Marchegiani: That's good. And again, some things that we can do. Evan already mentioned some, but just to re-summarize, we can do Brom Moline on Empty Stomach Nattokinase or S Peptidase, empty Stomach.
We can also do curcumin probably more in a phyto zone format, so it's better absorbed, curcumin, the spice, it doesn't get absorbed that well by itself. Or we can do things like frankincense. We can even do things like an Epsom salt foot bath or total body bath or Epsom salt gel, which is a magnesium based gel on our.
On our skin and absorb it. We can do higher dose fish oil anywhere between four to six grams. If we go too high, make sure the fish oil's good and take some exo extra vitamin C or curcumin with it to prevent lipid peroxidation. We can, we mentioned boswellia. We can do white willow bark as well. We can also do vitamin C.
We can do cetin. These are all good things. NAC is wonderful, has a mild anti-inflammatory plus it helps with cells getting really sticky and coagulating. Is there anything else? [00:22:00] There's arnica. Whether it's the 300 or 30 or 300, there's there's two numbers, versions, one's more acute, one's more chronic.
That's still really nice as well as a gentle homeopathic. Is there anything else for pain that you wanted to highlight that we get the frankincense or which is the same as boswellia? Anything else? We talked about the curcumin. White Willow, the enzymes. Cannabis
Evan Brand: you?
Dr. Justin Marchegiani: Yep.
Evan Brand: Yeah. We can't ignore cannabis.
Dr. Justin Marchegiani: CCB D.
Evan Brand: Yeah, that could be topical. That could be inhaled. That could be liquid tinctures. There's a lot of options. So look at your local dispensary. You've got so many states now with medical. And or recreational programs, you can get a one to 12 ratio, meaning one part THC to 12 part CBD, which means it's gonna have literally, virtually no psychoactive effects.
So if you're worried about that for driving or work or your job or whatever it is, you'd be fine. But the THC is a. I forget what they call it. It's basically a catalyst, if you will, for the CBD to work better. So if you're in a state where you can only get pure CB, D [00:23:00] topically, you can use that. So joints, it can be great for that, but.
It doesn't often work as good, and there's tons of literature on fibromyalgia MS and cannabis, so I think it's an incredible herb that has good potential. Can it be abused? Yeah, for sure. Should you be doing it if you're under 25, should you be doing high THC? Probably not. I think Daniel Amon. Blows it out of the water a little much.
He's a little excessively fear mongering about it because there are so many good case reports I've seen where people have turned their life around, whether that's mood disorders, chronic pain, cancer, you name it, and then check out the documentary Running From The Cure. That's an incredible one about what's called RSO, which is a special type of oil, which is incredibly terpene rich.
Dr. Justin Marchegiani: Yes. RSO is that The Rick Simpson Oil.
Got it. And also, I wanted to
Evan Brand: highlight, I've had some people, I've had some people stage three, stage four, yeah. Into the rope few months to live and they've been able to turn around. There's also some holistic oncologist in Colorado. I've [00:24:00] interviewed Nayha Winters, and you can look her up.
She's a holistic oncologist and I know she trains a lot of doctors and cannabis, specifically the RSO is in almost all of the oncology protocols.
Dr. Justin Marchegiani: And I've seen a lot of, like logical fallacy debates on Twitter. I've taken part in some of them, or where someone's saying, this can't help with, the C word.
The cancer word. Yeah. And find me a case study where this thing just helped it alone. The problem is I would never recommend no matter what condition, you have to only do one thing. It's like saying, oh, if you have cancer, you should only work on your vitamin D. You should only work on eating organic, or you should only work on your blood sugar.
It's like you should have at least 10 to 20 things. In the pot going all at once. And so that I think is the false equivalency when people look at and say, this works. And I think that fallacy came about because of drug companies and the double blind placebo control trial. We wanna isolate and know is this the variable that is gonna be the thing that helps us?
And you never, when you're sick, you always want at least [00:25:00] 10 or 20 things in the fire. And that's why conventional medicine does not do well in the fun in the. Sorry. That's why functional medicine does not do well within the con convention, the conventional medicine type of double blind placebo control study environment.
'cause we have too many variables going. Yeah. And highlight one more thing on the inflammation front. I mentioned lasers, I mentioned red light, I mentioned infrared light. All wonderful modalities to do. You mentioned peptides. Sometimes those peptides may be better to inject in an area because we can get more concentration in the shoulder if there's an issue versus having the body.
Pull from it or take from it systemically. And also, if you're really inflamed right and your diet's really crummy, a fast can be wonderful. Part of the reason why people do well with fast or feel great if your diet's really inflammatory and then you eat nothing, guess what happens to the inflammatory load?
It comes down a lot 'cause you're not putting in, I, I'd say if you're eating really good fats and really good eggs, lung as you don't have a food allergy, you're eating good quality fish and beef and vegetables, and then you don't eat, you're not gonna probably [00:26:00] get the same benefit from fasting, like from an inflammation standpoint.
Obviously there's cellular auto aging, other things that are good from a, a stem cell telomere standpoint. But part of that fasting benefit is you're cutting out a ton of inflammatory food if your diet's junky. So that's a good thing if you're out there. But just make sure you have electrolytes and some bone broth or something simple in there for your tummy.
Anything else?
Evan Brand: Yeah, said man. No, we could wrap it up here, I think is a good stopping place and yeah it's said about the multi-variable thing. This idea that you're gonna just keep everything in your life the same, but yet you're gonna take this magic pill. It's mind blowing and it's actually quite pathetic, really, this model, and you have to address.
All the different levers. This idea that we're ever gonna have some magic cure. That's just this one little thing. One thing, here it is. That's very little. That's silly. Very little. That's silly. It's never
Dr. Justin Marchegiani: gonna happen. We see it with the eye debate, right? That medication that begins with an eye that's over the counter now.
This thing doesn't, yeah, but you wouldn't, I would never recommend anyone just. Only do that. Yeah. That may be like a little nudge in your corner. And then a lot of things are synergistic, so when that's good and your blood sugar's good, and your sleep's good, and your vitamin D's good and you're moving a little bit and you're doing good [00:27:00] with prayer and meditation and everything else, that's everything's synergistic and logarithmic.
So just keep that in mind. Yeah. Yep.
Evan Brand: Yeah. Let me show this real quick. Yeah. And then we'll, and then we'll call, lemme just pull this up real quick. Sure. I just want, 'cause you're making a good point here. I wanna just show people this, so this protocol here, and this would apply for just the virus or the injection.
There's not just one thing. Okay. The, yeah. The. That's here. But you've also got intermittent fasting. You've got LDN, you've got nattokinase, you've got melatonin, magnesium, methylene, blue, vitamin D, K, two, resveratrol, probiotics, omegas, nac, C, black arginine, citruline, Brom Lane, vitamin C. So this idea that one thing's gonna get you out of the woods here.
I mean look at this, there's a lot.
Dr. Justin Marchegiani: Yeah, I see that it happens a lot and we don't wanna have it have that mindset and also. I mentioned this on Santa Cruz Medicinals podcast with Brendan last month is that over 50% of peer review literature is not reproducible. And so we have oh, the New England Journal of Medicine, or The Lancet or [00:28:00] jama.
It's these are such prestigious journals. It's but the problem is most of what they publish. I'd say almost the majority cannot be reproduced. And so that's a big deal. And so if you can't reproduce it, what does that tell you about the quality of the data? And so we need to put more, more data behind or more emphasis behind studies that come out that we can actually reproduce, right?
And so the reason why I say that is because the things that we talk about, if there's not a lot of money behind it, you're not going to see it elevated. But a lot of the things that we talk about, you're gonna see studies where it is reproducible. And so that would elevate it, right? If you change the metric and how you weigh data it would allow more of these natural compounds to be elevated.
'cause there's a lot of data saying these things are good things. That's all.
Evan Brand: Yeah. And we're validating this stuff every single day in the practice. So if you need help, reach out to dr jed justin health.com or myself@evanbrand.com. We can help and do. Consultations worldwide. We can facilitate these labs and we're seeing this stuff because we're in the trenches.
So [00:29:00] is it cool? Is it sexy to see someone on a podcast say, yeah, this new study came out and showed dah. It's okay, great. We knew vitamin D was good. Glad to hear that vitamin D improves dysbiosis and therefore maybe reduces inflammation. Great. But you still have parasites. You still have mold, you still got line, you still got mitochondrial issues, and yeah it's good for clipping. It's good for these viral YouTube shorts. It's good for this social media content. New study dah. Everybody likes it and shares it. Oh my God. Oh my God. The new miracle. The new miracle. But it's generally, as you said, 10, 20, 30 levers. So let us help you to find exactly what levers you need to be tweaked, and we'll be happy to do that.
So Dr. J justin health.com, evan brand.com. Reach out to us, let us know how we can help. This stuff is, we love this stuff. We've got the passion, we've got the energy. Let us help you. It's hard to do this stuff alone. It's hard to just go on Amazon, buy the number one bestselling probiotic and then you're mad.
You're not better. It's it's deeper than that.
Dr. Justin Marchegiani: It is. Absolutely. If you guys enjoy the content, please give us a a follow a comment down below. We [00:30:00] appreciate it. We're here to support you worldwide and if we don't come back on before the Christmas season here, have wish everyone at home ate.
Merry Christmas and a very happy holidays to you and your family as well. Great to chat with you, Evan. Anything else my friend? No, you guys take care of each other. We'll see you soon. Take care y'all. Bye.
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