The Top 5 Nutrients to Address Gut Inflammation and Leaky Gut | Podcast #339

Whenever you are worried about your gut health and having inflammation, Dr. J and Evan are here to share five essentials that may help you.

Lessen your intake of highly processed foods, refined carbs, sugar, artificial sweeteners, and alcohol. Opt instead for anti-inflammatory foods like fruits, vegetables, spices, and healthy fats but, if you suspect that several foods are triggering inflammation in your gut, it might be worth giving an elimination diet a try.

It may require removing foods from your diet that you suspect are connected to your gut problems for roughly two to three weeks at a time. Inflammation in your gut may cause a host of harmful health symptoms, from fatigue to irregular periods and chronic constipation. However, a few changes to your diet and lifestyle might be vital to helping you control these symptoms and improve your gut health.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this podcast, we cover:

0:48   Looking into the Gut Deeper

3:53   Good Foundations

6:26   Chewing is Important

8:22   Mushrooms as Anti-Inflammatory Properties

16:00  Probiotics

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Dr. Justin Marchegiani: Hey guys, it’s Dr. Justin Marchegiani here. Today’s podcast is we’re going to be talking about the top five nutrients to address gut inflammation, and leaky gut or gut permeability. So this is a topic that’s pertinent to a lot of our patients as gut inflammation, there’s usually some component in why they’re not feeling good. So I’m really excited to address this today with Evan, we’re gonna dive into the things that we do clinically, the things that work with our patients, the things that actually get results, we’ll break it down, and we’ll kind of give you guys some action items for today as well. And what’s cooking man? How are we doing?

Evan Brand: Hey, you’re doing really well. And you know, we always come up with a title. And then we over deliver on that title. So we’re calling this something along the lines of top five nutrients to help your gut or to heal your gut or support intestinal permeability, but maybe we end up going over five. So I’m just gonna go straight to my favorite because it’s so easy. It’s so broad spectrum in its use. And it’s so safe for people across the board to use it, whether it’s kids, adults, the elderly population, even people that don’t have testing, you know, our philosophy is test don’t guess we want to have the data, we want to have good stool testing, and good organic acids testing to look into the gut deeper and figure out what’s going on under the hood. But there is usually a three, sometimes four week timeline between talking with a client or a new patient and then getting the test results. So what do we do to help these people in that in between time before we can do the real work based on the data, I’d say my favorite is probably aloe, and specifically you and I use an aloe extract. It’s a 200 to one, so it’s 200 pounds of gel converted to one pound of extract, and then that’s encapsulated. We had a young boy, not super young, maybe 16 17. But he was diagnosed with autoimmune gut issues, Crohn’s all sort of colitis, actually pan colitis where the whole digestive tract was affected major bleeding in the store. We got him on simply a 200 to one extract of aloe. And within three weeks, we did a new gi map stool test, and we dropped his calprotectin levels, which is his gut inflammation by 1000 points, just by aloe alone.

Dr. Justin Marchegiani: Unbelievable. Yeah, it’s powerful what nutrients can do now I always tell patients, if you’re trying to come in and make some changes out of the gates, I mean, your best bang for your buck would be fixing the food, because the food is constantly getting your body getting your gut in flames. So the first thing we can do is look at the the the inflammatory food that could be coming in this could be gluten or other technically gluten free grains like corn, oat, rice, those kinds of things. So you want to really get the grains out, you want to really get a lot of the poly polyunsaturated omega six vegetable oils. And again, the reason why vegetable oils tend to be more, let’s say poor is because they’re highly processed to extract the fat. And the processing actually damages the fat and creates free radical stress within those fats. Because the more you take in damaged fats, your body has to utilize antioxidants to stabilize the fats. So they don’t create free radicals. And so it depletes a lot of your antioxidants. And then those fast take on and become part of your cell membrane. And to have healthy cells you have to have good membrane. Because the membrane essentially is the brain of your cell. It provides a lot of good cellular communication happens with the membrane. So if you have junky fats, whether it’s omega six junky fats, or trans fats like hydrogenated soybean oil, right, those kinds of things, canola, you know, safflower, those are going to be more junky omega six, and they’re going to really not make the healthiest cell membranes, they’re going to deplete your antioxidant reserves. And if they’re on the trans fat side, they’ll make your cell membranes very inflexible too.

Evan Brand: Yeah, good point. And I apologize for skipping over the diet piece, you know, you think of the typical American person, they think, just give me the pill. Give me the magic remedy. So we’ll talk about some of those remedies. But yeah, you make a great point, you can’t go out to Pizza Hut for dinner, and then just take an aloe capsule, and everything’s going to be okay. Correct.

Dr. Justin Marchegiani: Yeah. So that’s it’s good to look at the foundation out of the gates. I’d also say like, I’ll just kind of put this next category into a broad category and just say, amino acids. And these amino acids could be things like an acetylglucosamine, NaG that could be things like glycine, which are going to be very high in collagen or bone broth. And they could also be things like glutamine, so I kind of put these in the amino acid bucket, when they tend to be very good support for the entire sites of the gut lining, that can be used as fuel for the gut lining, they also can help with gut permeability. And, and glycine is a really good backbone for connective tissue. So it can be very helpful for that lot of that connective tissue healing out of the gates.

Evan Brand: So how about enzymes? When you hear nutrients to heal the gut or support the gut, you don’t necessarily think about enzymes, you think of more like you mentioned, the glutamine, Aloe, the kind of calming, soothing things, but I would argue enzymes have a role in helping with reducing gut inflammation simply by improving digestion and reducing the putrifying and fermenting of foods because I know my gut was Super inflamed. If I look back at some of my original stool tests, when I had gut infections, yes, I was doing things to soothe my gut, but simply just treated, the infections alone got the inflammation down. And part of that process of treating the infections was using enzymes, because my digestion was so terrible, I would get exhausted after a meal. And that was a sign that I had low stomach acid. So I would say the enzyme should be on our list here, because so many people do to age due to stress. Maybe you’re eating in a loud restaurant, like you’re on your lunch break for work, and you’re listening to us or there’s music, boom, boom, boom in the background, and you’re sympathetically stressed while you’re eating enzymes, to me would be a good insurance policy to help break down your foods and then therefore reduce inflammation.

Dr. Justin Marchegiani: Yeah, foods are not broken down properly, they’re going to sit, they’re going to ferment, they’re going to purify, they’re going to read certify also, those foods are more likely to create hydrogen and methane gases because they’re fermenting, and those gases can throw off your motility, motility and how you move the bowels. And if the bowels are one too short, or should take too fast on the diarrhea side, you may not absorb those nutrients well. And if they’re too long, on the conservation side, you may reabsorb fecal toxins. And so you know, long or short on the bowel motility can definitely affect absorption or create more toxins in the body. So I think that’s a big one. And then just kind of connecting the enzymes and we could throw HCl in there too, because HCl helps activate enzymes, I would say chewing, chewing and and really just the mastication and healthy eating habits because chewing your food up really fine, allows more surface area for those enzymes and acids to work. So you can have a good amount of enzymes or acids, you only have a couple of chews. you swallow your food, those enzymes and acids aren’t gonna work as good as you really chew it up, you know, 30 to choose one chew per tooth, you know, ideally like an oatmeal like consistencies and allow those enzymes and acids to work better.

Evan Brand: Yeah, I’m 18th down. So I guess I get off the hook with 32. You know, I have my wisdom teeth and my 12 year molders out so.

Dr. Justin Marchegiani: Oh, yeah, there you go. I mean, I have my wisdom teeth out as well. So I’m kind of at 28 as well. So I get it. So let’s just say 30 plus or minus a couple.

Evan Brand: It’s hard. I’ve tried to do that I’ve tried to do that many choose, oh man, my jaw gets tired. So and that’s the that’s the problem too, that we have with our food is like you go to Chipotle, a for example. Everything’s really soft. Like if you get rice if you get like carnitas. Or if you get the chicken, you barely have to chew it. It’s almost like mush. So I try to personally seek out occasionally I will seek out whether it’s like beef jerky, or no bison jerky or even just a steak, you know, I try to really get something that works my job because I just feel like in America, our food is so soft and easily digestible, that we don’t have to really chew anymore.

Dr. Justin Marchegiani: Yeah, so if you have a nice steak or a nice whole chicken, just make sure you chew it up. Same thing goes with over hydrating, you know, try to get your first thing I do is and I get to go eat a meal, I kind of go to the reverse osmosis filter, get a nice big glass of water to add some minerals, one, two, and then I get my meal going that way it gives me 10 15 minutes or so for everything to absorb. And of course the colder the water you got to take a little bit longer because your body holds that water in your stomach, heats it up to about room temperature and then passes it through. So the colder that water is, the longer you should wait in between the meal

About mushrooms. This is something that you know, just doing a little bit of research before we hit record, that this is something that I don’t necessarily go to right out of the gate but I’ve been using mushrooms for a long time. I know you and I personally have been taking mushrooms for a long time. And it turns out that for example, Lion’s Mane mushroom has some really, I would say probably just as impressive as some of the other herbs you’re mentioning, whether it’s like dgl, licorice or marshmallow kind of the conventional gut healing ones. Lion’s Mane has some really awesome anti inflammatory properties. There were two papers that we had found here on Lion’s Mane mushroom being shown to protect from and shrink gastric ulcers. Also, Lion’s Mane was shown to significantly improve symptoms of two major inflammatory disorders of the digestive system. And so that’s cool, because normally we’re using Lion’s Mane for cognitive problems. I know for me, my brain is much more clear. I’ve got Lion’s Mane mushroom in my system right now. I took two capsules this morning, and I certainly feel it mentally. But I did not even think that I was feeling it in my gut. So that’s cool.

Totally. Yeah, that gets really important. Again, a lot of gut issues, the immune system can be a big player at it. And so of course, if you’re able to modulate the immune system with the medicinal mushrooms, or immunogenic compounds that are going to be in those mushrooms, whether it’s beta one, three, D glucan, whatever that is, it could have an effect on gut permeability and improving digestion. I think all that’s very, very important. Also, just kind of one pet peeve of mine. Someone in the comments was chatting about this. A lot of people when they talk about leaky gut, they talk about leaky gut like like it’s the cause of Problem. leaky gut is the effects of on what’s happening with the gut. So the more inflamed you are, the more you’re not breaking down your food. The more crappy The food is, the more inflammatory The food is, the more dysbiosis we have, the the lack of certain nutrients we have, the more stress we are right. All that then creates and increases the chance of gut permeability. Gut permeability isn’t the cause unto itself. It’s the effects of a lot of other issues happening. So when people talk about Oh, you gotta fix the leaky gut. It’s like, not necessarily, you know, it’s like, it’s like saying, Oh, we have to fix. Imagine you have a leak in your roof and the waters pulling on the carpet below you. So we got to fix that water on the floor. It’s like, No, no, you fix the hole in the roof. And again, it may be semantics, but we got to call a spade a spade. If the water’s coming into the roof, you talk to them, we got to fix the hole in the roof. You don’t say we fixed the the water on the ground, right? So I just want everyone I want to train everyone to kind of get thinking about things from a root cause standpoint, versus labeling the damage at the end result conventional medicines really good at labeling damage down here and not talking about the effects of top that should the cause up top there labeling the effects down here. So we want to go root cause?

Yeah, that’s great. And I’m sure we could come up with other analogies on it. But that makes a lot of sense. It’s kind of like, okay, we need to come in with the towel. Oh, no. Now we have this super absorbent towel, this towel is going to absorb 1000 times more water on your floor than any other towel. And then yes, this, this carpet is mold resistant. So if you use this carpet, that water in your carpet won’t create mold, but you’re still missing the frickin hole in the roof roof.

Exactly, exactly. So we just got to really be on top of that. Make sure everyone’s thinking root cause I think that’s really helpful.

Well, let’s call it out. Let’s call out why that happens, though. It’s simply money. And it’s the supplement industry. There’s a lot of money. Yeah, it’s marketing. There’s a lot of money made on leaky gut this and this leaky gut book and this leaky gut protocol and this leaky gut practitioner. The problem is you could take all these leaky gut support for a decade and never treat the infections like if you just went and did like you mentioned glutamine, and we hit the zinc carnosine and the dgl. And we did the aloe, like we talked about in the beginning, none of those are going to erase a blastocyst is hominis, parasite infection, none of those are going to get rid of Giardia. None of those are going to treat the H pylori, they may help. But they’re definitely not going to eradicate the issue causing the leaky gut in the first place. So that’s just marketing. It’s money involved in this. And, you know, as practitioners, I think it’s really smart of you to call it out like that, because it’s, it is frustrating for us because we’ll look on a new client or new patients intake form. And they’ll be taking all these quote leaky gut supplements. Yeah, I found this leaky gut protocol online, and I still have all these digestive problems. And it’s like, well, yeah, look at your stool test, you have all these issues. And you could do that for 20 years and never fix it. So I could rant on that all day.

Yeah, other thing I would just say out of the gates is it’s okay to palliative Li support the leaky gut, we just have to make sure when you’re palliative Li supporting something we’re also root cause supporting it as well root cause fixing it. Palliative support, totally fine, right. Nothing wrong with that we just got to call a spade a spade and and not pretend the palliative leaky gut support is root cause support. Yeah, long as we can do that, then I think we’re pretty good. Next thing I would highlight out of the gates and you see this herb being listed as being very helpful for the gut permeability, but it’s also very helpful on the adrenal. So that’s licorice. And so when we use licorice is a lot of licorice being used in leaky gut supports. That’s that’s d glycerides. And this is the glycerides component of the licorice is pulled out. And the glycerides component of a licorice is is the component that slows the breakdown of cortisol, I think it’s the 11 beta hydroxy steroid dehydrogenase to enzyme. The licorice inhibits that enzyme. That’s the enzyme that helps break down cortisol. So we know cortisol too low, we need healthy levels of cortisol to actually build up the gut lining. It helps with building up the gut lining. Of course, if our cortisol levels are too high, and we’re chronically stressed, right, that can also break down the gut lining. We know that with people that are chronically stressed getting ulcers, right, we know that as well. And so when we look at licorice, it really helps with cortisol improvement. So if we do a cortisol test, and we see chronically low cortisol, that can actually help with the gut lining with the mucosa with the stomach with the duodenum. And that can actually help with the cortisol bringing that back up. And that can help build back up that gut lining. And so we like licorice, that’s non diglycerides for the gut and Nanda glycerides licorice, we give it typically orally sublingually, to our patients, that will eventually trickle downstream to the gut as well. And so licorice can be a powerful thing. You just have to be careful if you’re giving a non diglycerides version that people that have already higher level of cortisol, that may make things worse. So we just got to make sure we’re testing that to know what kind of pattern we’re seeing.

Yeah, that’s a good point. So we could do a whole part two on that. If you want. Give us some feedback. Like maybe the gut hormone connection. And we could hit that in detail. But yeah, you highlighted a very important point, which is that cortisol is involved with this whole process. And it really is a Goldilocks zone. If you have too little cortisol, you’re exhausted. And you’re probably going to be dependent on stimulants and caffeine and sugar and things that are going to damage your gut. But then simply, you don’t have enough to build up the gut. And then if you have too much, now you’re catabolic, you’re breaking down your muscle tissue, and you’re breaking down your gut barrier. That’s probably part of the reason that I lost a lot of weight and a lot of muscle. When I first moved to Texas, I had gut infections, and I was incredibly stressed, just moving and leaving my family behind, you know, emotional stuff, homesickness gut infections, I had the perfect storm to tear up my gut. So I can tell you firsthand that adrenal supports did help. And that was probably because it was helping regulate the cortisol levels, which then in turn, took the load off my gut, so to speak.

100% Yeah, I like that. And so it’s good to really make sure that’s under control. 

Evan Brand: How about probiotics? I think it’s worth mentioning. These are totally valuable tools that can help regulate histamine. Yeah, and regulate bacteria with it. So let’s dive into that.

Dr. Justin Marchegiani: Yeah, so you have to you I said you have three to four big families. Okay. So you typically have your lactobacillus and bifidobacterium, which are typically come together and usually a good high quality broad spectrum probiotic. So my line we have one called profile, Florida doesn’t have a lot of the different lactobacillus whether it’s kci acidophilus Bulgaria’s brevis, rhamnosus. And then of course, you have a lot of the bifidobacterium whether it’s bifidobacterium, bifidum, longum, brevis, right. So those are your broad spectrum lactobacillus or bifidobacterium. Probiotics, lots of good data, lots of good research anywhere from food poisoning for inflammation reduction, gut permeability reduction. nutrient absorption is all kinds of different studies connecting the dots on those so that’s kind of the bifidobacteria, lactobacillus Of course, we have more of our spore based or soil based probiotics. These are going to be a lot of your bacillus strains, right, whether it’s bacillus, subtlest class ei coagulans, like Informix, right. These are the bacillus strains. These are really good if you are very much cebo sensitive, fodmap sensitive, we may use some of these over a bifido lactobacillus species. And then of course, I’m a big fan of the probiotic that’s kind of more of a beneficial yeast called Saccharomyces boulardii in my lammie, one called sacral flora, again, we’ll put the links below for for all y’all so if you want to see it, we’ll put the links below sacral Flora Saccharomyces boulardii is very helpful a lot of studies on it, helping to improve immunity in the gut IGA IGA levels going to get low and just gut inflammation or gut stress. Of course, it’s going to help with food poisoning a lot of studies on it helping with H. pylori, C. diff, Clostridium difficile, blastocystis hominess. It also helps crowd out yeast and Candida so there’s a lot of excellent benefits with saccharomyces we love it and it’s usually going to be a core part of my probiotic, my fifth r which is repopulation re inoculation on the good healthy probiotics, once the fourth hour is done right fourth hours and to be removing the gut bugs removing the gut infections. Fifth hour, we come in repopulate re inoculate with good bacteria. Most people kind of sweet they want to start probiotics sooner, and that may not be the best step. Not saying it may not help. But some people have just found one that’s just a lot of pills. And two, if they have a lot of bad bugs in there. It’s like going and getting a whole bunch of good fresh grass seeds throw down on a lawn full of weeds, right? You got to get the weeds done before we throw down the seeds right got to get the car washed or we get waxed.

Evan Brand: Kind of like that. Yeah, we had a lot of good feedback on the podcast we did remember we were talking about probiotics and how a lot of new research is showing probiotics are being used to help with getting out mycotoxins and we know that mold toxins damage the gut. So yes, so I have been I’ve honestly been working in probiotics into the protocol sooner and most people do well. There are some like you said that just don’t you got to pull the weeds before you throw the seeds. But there are a lot of people doing really good with throwing probiotics and sooner in the protocols now. So like you said, if they can handle the amount of pills, maybe we try to sneak one or two in or we could do like powdered versions, typically, it’s like a quarter teaspoon, we could throw in a blend like that sack be you could you could do powder and maybe throw it in a smoothie or something. So we are trying to integrate those a lot. And I’ve had amazing success personally with probiotics. So I think it’s interesting, there’s still a lot of people that poopoo probiotic probiotics I know you and I we kind of get, you know, so caught up in the clinical trenches that we may miss some things, but I do get a couple of emails, you know, here and there from from people, clients sending them like, hey, this guy like says probiotics are a waste of money, and you know, that they don’t work. And I would just say that’s not true. We have so much clinical data personally.

Dr. Justin Marchegiani: It’s all about context, right? It’s like if someone comes in, they have chronic gut issues, and they’re just taking a probiotic thinking that that’s going to be the answer to their gut problems. It’s probably not right, and that’s where we’re trying to have a comprehensive functional medicine plan. That’s root cause and not just trying to Pro supplements at the wall thinking that that’s going to fix it. So yeah, I understand if that you know where that person is coming up with that, that bias that biases from not having a comprehensive root cause plan with a functional medicine practitioner, they’re just trying to throw stuff at them instead it hoping it will fix the symptoms, not fix the root cause.

Well, here’s Yeah, good, good point. Here’s the other thing, too, it’s even some probiotic companies will say that about other companies, it’s more of a marketing thing like, hey, their probiotic is crap, or it doesn’t work because of X, Y, or Z. But I will just say with what you and I use, clinically, we’re using professional supplement manufacturers exclusive only to health care providers. And a lot of the stuff we use, we have extended release technology. So when arguments like probiotics are going to die in the stomach, they’re not even going to make it to where they need to. But a lot of the new technology we use, they’re not even going to break open, they’re going to be resistant to the stomach acid. So that’s another problem too, when you hear these little like, super sometimes buzzworthy type articles. It’s not taking into consideration the quality, the quantity, the purity, the potency, the technology involved, it’s like probiotics, they get the label, and then that’s it. And that’s just not a fair classification.

Correct. And then also consumer reports that a study on probiotics a couple years back maybe 5 10 years ago. And what they found is most probiotics that they put a number on the outside of the bottle, hey, this is how many colony forming units. And what a lot of the cheap companies do is they say, Okay, this is how many should have been in this probiotic at manufacturing of this product. Let’s say it’s 20 billion. Now, what the professional companies do is, right, when you’re buying high quality, professional ingredients, they’re gonna say this is how many colony forming units should be in this capsule at expiration. And so you’re looking at something like two to three times the amount of those that species that CFU on the bottle colony forming units, is going to be typically in there. So when you see like, in my probiotic, I think it’s 40 billion per two capsules, right? That’s going to be what’s in there two years from now at expiration, right? And so obviously, it’s going to be two to three times the amount of that before. And so you want to use professional companies. So what you see on the label is always worst case, scenario, number one, and then also how products are stored by professional companies is very important. So like, where we have our warehouses, like everything is stored in an air conditioned or a refrigerated environment for a lot of our probiotics, some don’t necessarily need that. But which we value, the the scenario and how that store because that really increases potency, too.

Evan Brand: Yeah. And the funny thing is, too, we’ve seen some papers on supposedly expiration dates, you know, this is something that you and I are forced to do with the professional companies we work with. But you know, we’ve seen some research on supplements from 2030 years ago, still being viable, meaning they still had some potency and purity to them. And obviously, they still had a biological effect. So to me, I would if I had to pick like a consumer shelf bought probiotic, or a suppose that expired professional product, I’m going to go for the supposedly expired product, I’d go for a five year old professional probiotic, then, you know, on the shelf today consumer level.

Dr. Justin Marchegiani: Yeah, exactly. And also a lot of the probiotics or supplements that require refrigeration on the warehousing side, a lot of times you’re just not going to get that on Amazon, you’re not going to get that level of specificity just because that’s not how their warehouses are set up. And so with ours, we make sure that that refrigeration components is there because we’re working with patients and we need we need that potency, because we’re trying to get clinical outcomes, right. We’re trying to sell and provide a clinical outcome for the patient. And if we’re just providing products that aren’t meeting that standard, we’re not going to win. And of course, we want to be successful on that front.

Evan Brand: Yeah, yeah. Well say Well, I think we covered a lot of it. So the mushrooms are beneficial Lion’s Mane the mushroom is amazing for the brain, but for the gut also Chaga mushroom would be great reishi mushroom could also deserve a good mention, you hit upon the amino acids. So the glutamine or the various types of glucose amines involved. We love amino acids, we use those all the time you mentioned like collagen also being you know, part of that makeup, we hit on some of the herbs like the the licorice, or the dgl version of it, the marshmallow, we like to use a lot, we hit upon the aloe, and then we hit the probiotics, I think those are the big categories. And then the enzymes we hit that too.

Dr. Justin Marchegiani: I think we did a really good job hitting a couple and I just I really want to plug in concepts, right? Like a lot of people, they just try to throw information at people and and try to memorize that. I think that’s not beneficial. But if you can just understand concepts, right? A concept is just something that sticks. You either get it or you don’t. And so we try to use a lot of analogies and understand we try to plug in a lot of the concepts of root cause versus palliative cause. We try to get you to think about, hey, if this helps, why does it help? is it just an anti inflammatory? is it helping just improve better digestion? is it helping your immune system? is it helping your adrenals and helping you that your body’s natural process to build back up that gut lining? What’s the underlying mechanisms if you understand that, then you see how it plugs into the greater matrix of healing.

Evan Brand: Yeah, I mean, I agree 1,000%. So, I think the big concept of today is Yes, here are some things here are some nutrients you can use. However, we really want to make sure you’re testing, not guessing. So if you do need the aloe to calm the gut for now, you need the enzymes to help improve digestion. For now, you notice that HCl is helping with your heartburn or you notice that the enzymes are reducing your bloating, or your burping or your gas. Great, but what led to all that in the first place? What led you to need the aloe because you had gut inflammation, what led you to need the enzymes, that’s where somebody like us can come in and help you figure that out and plot it on paper. And, you know, we’ve been through the trenches personally. And clinically, we’re always improving upon herself. You know, I work on my children, I know you work on your children, we’re giving our kids things to help their guts, I mean, so this is like a, there’s no finish line, I don’t want people to think, Hey, I just do this aloe for a month, and then I’m done. You know, there’s not a finish line with the gut, we’re constantly being exposed to new toxins and new pathogens. We’ve even seen with the virus that’s been going around a lot of issues with the gut there, we’ve seen a lot of issue with tissue destruction in the intestinal tract. So who knows? Right now with the 5 10 year outlook of the GI health in the US is right now, our guts are notoriously bad, due to glyphosate and other things, damaging them. So just a quick note, you kind of started with the diet all and with the diet 100% organic is important, if you’re going to go buy all these probiotics, but yet, you’re going to eat strawberries with an average of 22 pesticides on them. If they’re not organic, you’re wasting your frickin time and your money because we know all those pesticides are just killing the beneficial bacteria in your gut that you’re trying to re inoculate or repopulate with. So please go organic, you know, before you spend money on probiotics.

Dr. Justin Marchegiani: Exactly. And then also how long do these probiotic strains last in your gut, I mean, a lot of times, you’re going to see the data show in about one month or so. So that they don’t stay forever. So when you take a probiotic, it’s not like it’s there forever. So it’ll it’ll hang around typically for a month, it’ll help with a nutrient synthesis, it’ll help with nutrient absorption, it’ll help with inflammation, modulating the immune system, there’s some data that maybe the spore based probiotics hang around a little bit longer, and they may help proliferate the growth of other beneficial species. So just think when you take a probiotic, it’s not forever. Now the goal is that we’re getting some level of fermentable foods in your diet, whether it’s from sauerkraut, or low sugar kombucha, or some kind of fermented pickle or something, or, you know, cultured coconut milk or potentially high quality raw milk if you can tolerate it. So you know, that’s typically how we’re getting exposed to probiotics more on a day in weekend kind of situation. If you’re someone that can’t get that level of exposure with fermented oils from food, then you probably want to be on a probiotic a little bit more frequently, if you’re not getting those fermentable. So we just got to plug and play where we’re at. I think our ancestors probably did more fermentable foods, which is ideal. But if we can’t we plug in a good quality probiotic, or at least throw in something every couple of months, just to kind of fill in the gap to make sure we’re getting exposed to those good for mandibles.

Evan Brand: Yeah, great point, I just want to highlight what you said too, which is like your gut bacteria are actually going to help you with your health in other ways. So once gut bacteria optimize your healing the gut, you’re making neurotransmitters the way you should you’re making serotonin, you’re making things to improve yourself, you’re making B vitamins to help your energy and your mitochondria. So this is why I really the gut, I mean, we just we can’t stop talking about it because it literally is the foundation.

Dr. Justin Marchegiani: Exactly. So just kind of want to make sure that is understood. And that makes sense for everyone. We’ll put a list of recommended products down below. So you guys have access to those you want to support us support the show, we appreciate it put those down below. Also, if you guys want to reach out to Evan brand, head over to EvanBrand.com, Evan is there for you guys worldwide. And again, I’m there for you as well, justinhealth.com, Dr. J myself, there’ll be a little link button, you guys can click and reach out to us we are available worldwide to help you guys help you help support y’all. We want to make sure they have the support you need. And you have a good comprehensive plan to get what’s going in the right direction if you’re not having success. And then also just try to apply one thing today as well. If you’re having if you’re overwhelmed, and you’re having a sticking point great to reach out, if not just try applying this information, we want to really help as many people as possible. And we know we’re going to help many more people than we actually see in person with this information. So just make sure you’re applying it. And if you are enjoying it, share it with family and friends that could also benefit put your comments down below. Let me know the best part that you liked about this what resonate with you the most. And give us a like and share as well. We appreciate it.

Evan Brand: Yeah, and if you’re on the apple listening, if you’re on your Apple podcast app or Stitcher or wherever else, give us some stars, let us know what you think the show deserves between us both we have I lost count, but it was somewhere over 705 star reviews for our podcast in between our various feeds. So please give us some stars. Give us some sentences give us a blurb on whether you still call it iTunes or Apple podcast. We’d love to beat out people that are not clinically oriented. There’s still like top health podcast out there that it’s just theory theory theory theory. And then we have to like recalibrate people’s theories because they’re not clinically based. So we would love to beat those people. How do we beat those Before we go higher in the charts, how do we do that? With your reviews! So we have a some stars. 

Dr. Justin Marchegiani: Thanks to all you guys have a phenomenal day. Take careDr. Justin Marchegiani  

Hey guys, it’s Dr. Justin Marchegiani here. Today’s podcast is we’re going to be talking about the top five nutrients to address gut inflammation, and leaky gut or gut permeability. So this is a topic that’s pertinent to a lot of our patients as gut inflammation, there’s usually some component in why they’re not feeling good. So I’m really excited to address this today with Evan, we’re gonna dive into the things that we do clinically, the things that work with our patients, the things that actually get results, we’ll break it down, and we’ll kind of give you guys some action items for today as well. And what’s cooking man? How are we doing?

Evan Brand: Hey, you’re doing really well. And you know, we always come up with a title. And then we over deliver on that title. So we’re calling this something along the lines of top five nutrients to help your gut or to heal your gut or support intestinal permeability, but maybe we end up going over five. So I’m just gonna go straight to my favorite because it’s so easy. It’s so broad spectrum in its use. And it’s so safe for people across the board to use it, whether it’s kids, adults, the elderly population, even people that don’t have testing, you know, our philosophy is test don’t guess we want to have the data, we want to have good stool testing, and good organic acids testing to look into the gut deeper and figure out what’s going on under the hood. But there is usually a three, sometimes four week timeline between talking with a client or a new patient and then getting the test results. So what do we do to help these people in that in between time before we can do the real work based on the data, I’d say my favorite is probably aloe, and specifically you and I use an aloe extract. It’s a 200 to one, so it’s 200 pounds of gel converted to one pound of extract, and then that’s encapsulated. We had a young boy, not super young, maybe 16 17. But he was diagnosed with autoimmune gut issues, Crohn’s all sort of colitis, actually pan colitis where the whole digestive tract was affected major bleeding in the store. We got him on simply a 200 to one extract of aloe. And within three weeks, we did a new gi map stool test, and we dropped his calprotectin levels, which is his gut inflammation by 1000 points, just by aloe alone.

Dr. Justin Marchegiani: Unbelievable. Yeah, it’s powerful what nutrients can do now I always tell patients, if you’re trying to come in and make some changes out of the gates, I mean, your best bang for your buck would be fixing the food, because the food is constantly getting your body getting your gut in flames. So the first thing we can do is look at the the the inflammatory food that could be coming in this could be gluten or other technically gluten free grains like corn, oat, rice, those kinds of things. So you want to really get the grains out, you want to really get a lot of the poly polyunsaturated omega six vegetable oils. And again, the reason why vegetable oils tend to be more, let’s say poor is because they’re highly processed to extract the fat. And the processing actually damages the fat and creates free radical stress within those fats. Because the more you take in damaged fats, your body has to utilize antioxidants to stabilize the fats. So they don’t create free radicals. And so it depletes a lot of your antioxidants. And then those fast take on and become part of your cell membrane. And to have healthy cells you have to have good membrane. Because the membrane essentially is the brain of your cell. It provides a lot of good cellular communication happens with the membrane. So if you have junky fats, whether it’s omega six junky fats, or trans fats like hydrogenated soybean oil, right, those kinds of things, canola, you know, safflower, those are going to be more junky omega six, and they’re going to really not make the healthiest cell membranes, they’re going to deplete your antioxidant reserves. And if they’re on the trans fat side, they’ll make your cell membranes very inflexible too.

Evan Brand: Yeah, good point. And I apologize for skipping over the diet piece, you know, you think of the typical American person, they think, just give me the pill. Give me the magic remedy. So we’ll talk about some of those remedies. But yeah, you make a great point, you can’t go out to Pizza Hut for dinner, and then just take an aloe capsule, and everything’s going to be okay. Correct.

Dr. Justin Marchegiani: Yeah. So that’s it’s good to look at the foundation out of the gates. I’d also say like, I’ll just kind of put this next category into a broad category and just say, amino acids. And these amino acids could be things like an acetylglucosamine, NaG that could be things like glycine, which are going to be very high in collagen or bone broth. And they could also be things like glutamine, so I kind of put these in the amino acid bucket, when they tend to be very good support for the entire sites of the gut lining, that can be used as fuel for the gut lining, they also can help with gut permeability. And, and glycine is a really good backbone for connective tissue. So it can be very helpful for that lot of that connective tissue healing out of the gates.

Evan Brand: So how about enzymes? When you hear nutrients to heal the gut or support the gut, you don’t necessarily think about enzymes, you think of more like you mentioned, the glutamine, Aloe, the kind of calming, soothing things, but I would argue enzymes have a role in helping with reducing gut inflammation simply by improving digestion and reducing the putrifying and fermenting of foods because I know my gut was Super inflamed. If I look back at some of my original stool tests, when I had gut infections, yes, I was doing things to soothe my gut, but simply just treated, the infections alone got the inflammation down. And part of that process of treating the infections was using enzymes, because my digestion was so terrible, I would get exhausted after a meal. And that was a sign that I had low stomach acid. So I would say the enzyme should be on our list here, because so many people do to age due to stress. Maybe you’re eating in a loud restaurant, like you’re on your lunch break for work, and you’re listening to us or there’s music, boom, boom, boom in the background, and you’re sympathetically stressed while you’re eating enzymes, to me would be a good insurance policy to help break down your foods and then therefore reduce inflammation.

Dr. Justin Marchegiani: Yeah, foods are not broken down properly, they’re going to sit, they’re going to ferment, they’re going to purify, they’re going to read certify also, those foods are more likely to create hydrogen and methane gases because they’re fermenting, and those gases can throw off your motility, motility and how you move the bowels. And if the bowels are one too short, or should take too fast on the diarrhea side, you may not absorb those nutrients well. And if they’re too long, on the conservation side, you may reabsorb fecal toxins. And so you know, long or short on the bowel motility can definitely affect absorption or create more toxins in the body. So I think that’s a big one. And then just kind of connecting the enzymes and we could throw HCl in there too, because HCl helps activate enzymes, I would say chewing, chewing and and really just the mastication and healthy eating habits because chewing your food up really fine, allows more surface area for those enzymes and acids to work. So you can have a good amount of enzymes or acids, you only have a couple of chews. you swallow your food, those enzymes and acids aren’t gonna work as good as you really chew it up, you know, 30 to choose one chew per tooth, you know, ideally like an oatmeal like consistencies and allow those enzymes and acids to work better.

Evan Brand: Yeah, I’m 18th down. So I guess I get off the hook with 32. You know, I have my wisdom teeth and my 12 year molders out so.

Dr. Justin Marchegiani: Oh, yeah, there you go. I mean, I have my wisdom teeth out as well. So I’m kind of at 28 as well. So I get it. So let’s just say 30 plus or minus a couple.

Evan Brand: It’s hard. I’ve tried to do that I’ve tried to do that many choose, oh man, my jaw gets tired. So and that’s the that’s the problem too, that we have with our food is like you go to Chipotle, a for example. Everything’s really soft. Like if you get rice if you get like carnitas. Or if you get the chicken, you barely have to chew it. It’s almost like mush. So I try to personally seek out occasionally I will seek out whether it’s like beef jerky, or no bison jerky or even just a steak, you know, I try to really get something that works my job because I just feel like in America, our food is so soft and easily digestible, that we don’t have to really chew anymore.

Dr. Justin Marchegiani: Yeah, so if you have a nice steak or a nice whole chicken, just make sure you chew it up. Same thing goes with over hydrating, you know, try to get your first thing I do is and I get to go eat a meal, I kind of go to the reverse osmosis filter, get a nice big glass of water to add some minerals, one, two, and then I get my meal going that way it gives me 10 15 minutes or so for everything to absorb. And of course the colder the water you got to take a little bit longer because your body holds that water in your stomach, heats it up to about room temperature and then passes it through. So the colder that water is, the longer you should wait in between the meal

About mushrooms. This is something that you know, just doing a little bit of research before we hit record, that this is something that I don’t necessarily go to right out of the gate but I’ve been using mushrooms for a long time. I know you and I personally have been taking mushrooms for a long time. And it turns out that for example, Lion’s Mane mushroom has some really, I would say probably just as impressive as some of the other herbs you’re mentioning, whether it’s like dgl, licorice or marshmallow kind of the conventional gut healing ones. Lion’s Mane has some really awesome anti inflammatory properties. There were two papers that we had found here on Lion’s Mane mushroom being shown to protect from and shrink gastric ulcers. Also, Lion’s Mane was shown to significantly improve symptoms of two major inflammatory disorders of the digestive system. And so that’s cool, because normally we’re using Lion’s Mane for cognitive problems. I know for me, my brain is much more clear. I’ve got Lion’s Mane mushroom in my system right now. I took two capsules this morning, and I certainly feel it mentally. But I did not even think that I was feeling it in my gut. So that’s cool.

Totally. Yeah, that gets really important. Again, a lot of gut issues, the immune system can be a big player at it. And so of course, if you’re able to modulate the immune system with the medicinal mushrooms, or immunogenic compounds that are going to be in those mushrooms, whether it’s beta one, three, D glucan, whatever that is, it could have an effect on gut permeability and improving digestion. I think all that’s very, very important. Also, just kind of one pet peeve of mine. Someone in the comments was chatting about this. A lot of people when they talk about leaky gut, they talk about leaky gut like like it’s the cause of Problem. leaky gut is the effects of on what’s happening with the gut. So the more inflamed you are, the more you’re not breaking down your food. The more crappy The food is, the more inflammatory The food is, the more dysbiosis we have, the the lack of certain nutrients we have, the more stress we are right. All that then creates and increases the chance of gut permeability. Gut permeability isn’t the cause unto itself. It’s the effects of a lot of other issues happening. So when people talk about Oh, you gotta fix the leaky gut. It’s like, not necessarily, you know, it’s like, it’s like saying, Oh, we have to fix. Imagine you have a leak in your roof and the waters pulling on the carpet below you. So we got to fix that water on the floor. It’s like, No, no, you fix the hole in the roof. And again, it may be semantics, but we got to call a spade a spade. If the water’s coming into the roof, you talk to them, we got to fix the hole in the roof. You don’t say we fixed the the water on the ground, right? So I just want everyone I want to train everyone to kind of get thinking about things from a root cause standpoint, versus labeling the damage at the end result conventional medicines really good at labeling damage down here and not talking about the effects of top that should the cause up top there labeling the effects down here. So we want to go root cause?

Yeah, that’s great. And I’m sure we could come up with other analogies on it. But that makes a lot of sense. It’s kind of like, okay, we need to come in with the towel. Oh, no. Now we have this super absorbent towel, this towel is going to absorb 1000 times more water on your floor than any other towel. And then yes, this, this carpet is mold resistant. So if you use this carpet, that water in your carpet won’t create mold, but you’re still missing the frickin hole in the roof roof.

Exactly, exactly. So we just got to really be on top of that. Make sure everyone’s thinking root cause I think that’s really helpful.

Well, let’s call it out. Let’s call out why that happens, though. It’s simply money. And it’s the supplement industry. There’s a lot of money. Yeah, it’s marketing. There’s a lot of money made on leaky gut this and this leaky gut book and this leaky gut protocol and this leaky gut practitioner. The problem is you could take all these leaky gut support for a decade and never treat the infections like if you just went and did like you mentioned glutamine, and we hit the zinc carnosine and the dgl. And we did the aloe, like we talked about in the beginning, none of those are going to erase a blastocyst is hominis, parasite infection, none of those are going to get rid of Giardia. None of those are going to treat the H pylori, they may help. But they’re definitely not going to eradicate the issue causing the leaky gut in the first place. So that’s just marketing. It’s money involved in this. And, you know, as practitioners, I think it’s really smart of you to call it out like that, because it’s, it is frustrating for us because we’ll look on a new client or new patients intake form. And they’ll be taking all these quote leaky gut supplements. Yeah, I found this leaky gut protocol online, and I still have all these digestive problems. And it’s like, well, yeah, look at your stool test, you have all these issues. And you could do that for 20 years and never fix it. So I could rant on that all day.

Yeah, other thing I would just say out of the gates is it’s okay to palliative Li support the leaky gut, we just have to make sure when you’re palliative Li supporting something we’re also root cause supporting it as well root cause fixing it. Palliative support, totally fine, right. Nothing wrong with that we just got to call a spade a spade and and not pretend the palliative leaky gut support is root cause support. Yeah, long as we can do that, then I think we’re pretty good. Next thing I would highlight out of the gates and you see this herb being listed as being very helpful for the gut permeability, but it’s also very helpful on the adrenal. So that’s licorice. And so when we use licorice is a lot of licorice being used in leaky gut supports. That’s that’s d glycerides. And this is the glycerides component of the licorice is pulled out. And the glycerides component of a licorice is is the component that slows the breakdown of cortisol, I think it’s the 11 beta hydroxy steroid dehydrogenase to enzyme. The licorice inhibits that enzyme. That’s the enzyme that helps break down cortisol. So we know cortisol too low, we need healthy levels of cortisol to actually build up the gut lining. It helps with building up the gut lining. Of course, if our cortisol levels are too high, and we’re chronically stressed, right, that can also break down the gut lining. We know that with people that are chronically stressed getting ulcers, right, we know that as well. And so when we look at licorice, it really helps with cortisol improvement. So if we do a cortisol test, and we see chronically low cortisol, that can actually help with the gut lining with the mucosa with the stomach with the duodenum. And that can actually help with the cortisol bringing that back up. And that can help build back up that gut lining. And so we like licorice, that’s non diglycerides for the gut and Nanda glycerides licorice, we give it typically orally sublingually, to our patients, that will eventually trickle downstream to the gut as well. And so licorice can be a powerful thing. You just have to be careful if you’re giving a non diglycerides version that people that have already higher level of cortisol, that may make things worse. So we just got to make sure we’re testing that to know what kind of pattern we’re seeing.

Yeah, that’s a good point. So we could do a whole part two on that. If you want. Give us some feedback. Like maybe the gut hormone connection. And we could hit that in detail. But yeah, you highlighted a very important point, which is that cortisol is involved with this whole process. And it really is a Goldilocks zone. If you have too little cortisol, you’re exhausted. And you’re probably going to be dependent on stimulants and caffeine and sugar and things that are going to damage your gut. But then simply, you don’t have enough to build up the gut. And then if you have too much, now you’re catabolic, you’re breaking down your muscle tissue, and you’re breaking down your gut barrier. That’s probably part of the reason that I lost a lot of weight and a lot of muscle. When I first moved to Texas, I had gut infections, and I was incredibly stressed, just moving and leaving my family behind, you know, emotional stuff, homesickness gut infections, I had the perfect storm to tear up my gut. So I can tell you firsthand that adrenal supports did help. And that was probably because it was helping regulate the cortisol levels, which then in turn, took the load off my gut, so to speak.

100% Yeah, I like that. And so it’s good to really make sure that’s under control. 

Evan Brand: How about probiotics? I think it’s worth mentioning. These are totally valuable tools that can help regulate histamine. Yeah, and regulate bacteria with it. So let’s dive into that.

Dr. Justin Marchegiani: Yeah, so you have to you I said you have three to four big families. Okay. So you typically have your lactobacillus and bifidobacterium, which are typically come together and usually a good high quality broad spectrum probiotic. So my line we have one called profile, Florida doesn’t have a lot of the different lactobacillus whether it’s kci acidophilus Bulgaria’s brevis, rhamnosus. And then of course, you have a lot of the bifidobacterium whether it’s bifidobacterium, bifidum, longum, brevis, right. So those are your broad spectrum lactobacillus or bifidobacterium. Probiotics, lots of good data, lots of good research anywhere from food poisoning for inflammation reduction, gut permeability reduction. nutrient absorption is all kinds of different studies connecting the dots on those so that’s kind of the bifidobacteria, lactobacillus Of course, we have more of our spore based or soil based probiotics. These are going to be a lot of your bacillus strains, right, whether it’s bacillus, subtlest class ei coagulans, like Informix, right. These are the bacillus strains. These are really good if you are very much cebo sensitive, fodmap sensitive, we may use some of these over a bifido lactobacillus species. And then of course, I’m a big fan of the probiotic that’s kind of more of a beneficial yeast called Saccharomyces boulardii in my lammie, one called sacral flora, again, we’ll put the links below for for all y’all so if you want to see it, we’ll put the links below sacral Flora Saccharomyces boulardii is very helpful a lot of studies on it, helping to improve immunity in the gut IGA IGA levels going to get low and just gut inflammation or gut stress. Of course, it’s going to help with food poisoning a lot of studies on it helping with H. pylori, C. diff, Clostridium difficile, blastocystis hominess. It also helps crowd out yeast and Candida so there’s a lot of excellent benefits with saccharomyces we love it and it’s usually going to be a core part of my probiotic, my fifth r which is repopulation re inoculation on the good healthy probiotics, once the fourth hour is done right fourth hours and to be removing the gut bugs removing the gut infections. Fifth hour, we come in repopulate re inoculate with good bacteria. Most people kind of sweet they want to start probiotics sooner, and that may not be the best step. Not saying it may not help. But some people have just found one that’s just a lot of pills. And two, if they have a lot of bad bugs in there. It’s like going and getting a whole bunch of good fresh grass seeds throw down on a lawn full of weeds, right? You got to get the weeds done before we throw down the seeds right got to get the car washed or we get waxed.

Evan Brand: Kind of like that. Yeah, we had a lot of good feedback on the podcast we did remember we were talking about probiotics and how a lot of new research is showing probiotics are being used to help with getting out mycotoxins and we know that mold toxins damage the gut. So yes, so I have been I’ve honestly been working in probiotics into the protocol sooner and most people do well. There are some like you said that just don’t you got to pull the weeds before you throw the seeds. But there are a lot of people doing really good with throwing probiotics and sooner in the protocols now. So like you said, if they can handle the amount of pills, maybe we try to sneak one or two in or we could do like powdered versions, typically, it’s like a quarter teaspoon, we could throw in a blend like that sack be you could you could do powder and maybe throw it in a smoothie or something. So we are trying to integrate those a lot. And I’ve had amazing success personally with probiotics. So I think it’s interesting, there’s still a lot of people that poopoo probiotic probiotics I know you and I we kind of get, you know, so caught up in the clinical trenches that we may miss some things, but I do get a couple of emails, you know, here and there from from people, clients sending them like, hey, this guy like says probiotics are a waste of money, and you know, that they don’t work. And I would just say that’s not true. We have so much clinical data personally.

Dr. Justin Marchegiani: It’s all about context, right? It’s like if someone comes in, they have chronic gut issues, and they’re just taking a probiotic thinking that that’s going to be the answer to their gut problems. It’s probably not right, and that’s where we’re trying to have a comprehensive functional medicine plan. That’s root cause and not just trying to Pro supplements at the wall thinking that that’s going to fix it. So yeah, I understand if that you know where that person is coming up with that, that bias that biases from not having a comprehensive root cause plan with a functional medicine practitioner, they’re just trying to throw stuff at them instead it hoping it will fix the symptoms, not fix the root cause.

Well, here’s Yeah, good, good point. Here’s the other thing, too, it’s even some probiotic companies will say that about other companies, it’s more of a marketing thing like, hey, their probiotic is crap, or it doesn’t work because of X, Y, or Z. But I will just say with what you and I use, clinically, we’re using professional supplement manufacturers exclusive only to health care providers. And a lot of the stuff we use, we have extended release technology. So when arguments like probiotics are going to die in the stomach, they’re not even going to make it to where they need to. But a lot of the new technology we use, they’re not even going to break open, they’re going to be resistant to the stomach acid. So that’s another problem too, when you hear these little like, super sometimes buzzworthy type articles. It’s not taking into consideration the quality, the quantity, the purity, the potency, the technology involved, it’s like probiotics, they get the label, and then that’s it. And that’s just not a fair classification.

Correct. And then also consumer reports that a study on probiotics a couple years back maybe 5 10 years ago. And what they found is most probiotics that they put a number on the outside of the bottle, hey, this is how many colony forming units. And what a lot of the cheap companies do is they say, Okay, this is how many should have been in this probiotic at manufacturing of this product. Let’s say it’s 20 billion. Now, what the professional companies do is, right, when you’re buying high quality, professional ingredients, they’re gonna say this is how many colony forming units should be in this capsule at expiration. And so you’re looking at something like two to three times the amount of those that species that CFU on the bottle colony forming units, is going to be typically in there. So when you see like, in my probiotic, I think it’s 40 billion per two capsules, right? That’s going to be what’s in there two years from now at expiration, right? And so obviously, it’s going to be two to three times the amount of that before. And so you want to use professional companies. So what you see on the label is always worst case, scenario, number one, and then also how products are stored by professional companies is very important. So like, where we have our warehouses, like everything is stored in an air conditioned or a refrigerated environment for a lot of our probiotics, some don’t necessarily need that. But which we value, the the scenario and how that store because that really increases potency, too.

Evan Brand: Yeah. And the funny thing is, too, we’ve seen some papers on supposedly expiration dates, you know, this is something that you and I are forced to do with the professional companies we work with. But you know, we’ve seen some research on supplements from 2030 years ago, still being viable, meaning they still had some potency and purity to them. And obviously, they still had a biological effect. So to me, I would if I had to pick like a consumer shelf bought probiotic, or a suppose that expired professional product, I’m going to go for the supposedly expired product, I’d go for a five year old professional probiotic, then, you know, on the shelf today consumer level.

Dr. Justin Marchegiani: Yeah, exactly. And also a lot of the probiotics or supplements that require refrigeration on the warehousing side, a lot of times you’re just not going to get that on Amazon, you’re not going to get that level of specificity just because that’s not how their warehouses are set up. And so with ours, we make sure that that refrigeration components is there because we’re working with patients and we need we need that potency, because we’re trying to get clinical outcomes, right. We’re trying to sell and provide a clinical outcome for the patient. And if we’re just providing products that aren’t meeting that standard, we’re not going to win. And of course, we want to be successful on that front.

Evan Brand: Yeah, yeah. Well say Well, I think we covered a lot of it. So the mushrooms are beneficial Lion’s Mane the mushroom is amazing for the brain, but for the gut also Chaga mushroom would be great reishi mushroom could also deserve a good mention, you hit upon the amino acids. So the glutamine or the various types of glucose amines involved. We love amino acids, we use those all the time you mentioned like collagen also being you know, part of that makeup, we hit on some of the herbs like the the licorice, or the dgl version of it, the marshmallow, we like to use a lot, we hit upon the aloe, and then we hit the probiotics, I think those are the big categories. And then the enzymes we hit that too.

Dr. Justin Marchegiani: I think we did a really good job hitting a couple and I just I really want to plug in concepts, right? Like a lot of people, they just try to throw information at people and and try to memorize that. I think that’s not beneficial. But if you can just understand concepts, right? A concept is just something that sticks. You either get it or you don’t. And so we try to use a lot of analogies and understand we try to plug in a lot of the concepts of root cause versus palliative cause. We try to get you to think about, hey, if this helps, why does it help? is it just an anti inflammatory? is it helping just improve better digestion? is it helping your immune system? is it helping your adrenals and helping you that your body’s natural process to build back up that gut lining? What’s the underlying mechanisms if you understand that, then you see how it plugs into the greater matrix of healing.

Evan Brand: Yeah, I mean, I agree 1,000%. So, I think the big concept of today is Yes, here are some things here are some nutrients you can use. However, we really want to make sure you’re testing, not guessing. So if you do need the aloe to calm the gut for now, you need the enzymes to help improve digestion. For now, you notice that HCl is helping with your heartburn or you notice that the enzymes are reducing your bloating, or your burping or your gas. Great, but what led to all that in the first place? What led you to need the aloe because you had gut inflammation, what led you to need the enzymes, that’s where somebody like us can come in and help you figure that out and plot it on paper. And, you know, we’ve been through the trenches personally. And clinically, we’re always improving upon herself. You know, I work on my children, I know you work on your children, we’re giving our kids things to help their guts, I mean, so this is like a, there’s no finish line, I don’t want people to think, Hey, I just do this aloe for a month, and then I’m done. You know, there’s not a finish line with the gut, we’re constantly being exposed to new toxins and new pathogens. We’ve even seen with the virus that’s been going around a lot of issues with the gut there, we’ve seen a lot of issue with tissue destruction in the intestinal tract. So who knows? Right now with the 5 10 year outlook of the GI health in the US is right now, our guts are notoriously bad, due to glyphosate and other things, damaging them. So just a quick note, you kind of started with the diet all and with the diet 100% organic is important, if you’re going to go buy all these probiotics, but yet, you’re going to eat strawberries with an average of 22 pesticides on them. If they’re not organic, you’re wasting your frickin time and your money because we know all those pesticides are just killing the beneficial bacteria in your gut that you’re trying to re inoculate or repopulate with. So please go organic, you know, before you spend money on probiotics.

Dr. Justin Marchegiani: Exactly. And then also how long do these probiotic strains last in your gut, I mean, a lot of times, you’re going to see the data show in about one month or so. So that they don’t stay forever. So when you take a probiotic, it’s not like it’s there forever. So it’ll it’ll hang around typically for a month, it’ll help with a nutrient synthesis, it’ll help with nutrient absorption, it’ll help with inflammation, modulating the immune system, there’s some data that maybe the spore based probiotics hang around a little bit longer, and they may help proliferate the growth of other beneficial species. So just think when you take a probiotic, it’s not forever. Now the goal is that we’re getting some level of fermentable foods in your diet, whether it’s from sauerkraut, or low sugar kombucha, or some kind of fermented pickle or something, or, you know, cultured coconut milk or potentially high quality raw milk if you can tolerate it. So you know, that’s typically how we’re getting exposed to probiotics more on a day in weekend kind of situation. If you’re someone that can’t get that level of exposure with fermented oils from food, then you probably want to be on a probiotic a little bit more frequently, if you’re not getting those fermentable. So we just got to plug and play where we’re at. I think our ancestors probably did more fermentable foods, which is ideal. But if we can’t we plug in a good quality probiotic, or at least throw in something every couple of months, just to kind of fill in the gap to make sure we’re getting exposed to those good for mandibles.

Evan Brand: Yeah, great point, I just want to highlight what you said too, which is like your gut bacteria are actually going to help you with your health in other ways. So once gut bacteria optimize your healing the gut, you’re making neurotransmitters the way you should you’re making serotonin, you’re making things to improve yourself, you’re making B vitamins to help your energy and your mitochondria. So this is why I really the gut, I mean, we just we can’t stop talking about it because it literally is the foundation.

Dr. Justin Marchegiani: Exactly. So just kind of want to make sure that is understood. And that makes sense for everyone. We’ll put a list of recommended products down below. So you guys have access to those you want to support us support the show, we appreciate it put those down below. Also, if you guys want to reach out to Evan brand, head over to EvanBrand.com, Evan is there for you guys worldwide. And again, I’m there for you as well, justinhealth.com, Dr. J myself, there’ll be a little link button, you guys can click and reach out to us we are available worldwide to help you guys help you help support y’all. We want to make sure they have the support you need. And you have a good comprehensive plan to get what’s going in the right direction if you’re not having success. And then also just try to apply one thing today as well. If you’re having if you’re overwhelmed, and you’re having a sticking point great to reach out, if not just try applying this information, we want to really help as many people as possible. And we know we’re going to help many more people than we actually see in person with this information. So just make sure you’re applying it. And if you are enjoying it, share it with family and friends that could also benefit put your comments down below. Let me know the best part that you liked about this what resonate with you the most. And give us a like and share as well. We appreciate it.

Evan Brand: Yeah, and if you’re on the apple listening, if you’re on your Apple podcast app or Stitcher or wherever else, give us some stars, let us know what you think the show deserves between us both we have I lost count, but it was somewhere over 705 star reviews for our podcast in between our various feeds. So please give us some stars. Give us some sentences give us a blurb on whether you still call it iTunes or Apple podcast. We’d love to beat out people that are not clinically oriented. There’s still like top health podcast out there that it’s just theory theory theory theory. And then we have to like recalibrate people’s theories because they’re not clinically based. So we would love to beat those people. How do we beat those Before we go higher in the charts, how do we do that? With your reviews! So we have a some stars. 

Dr. Justin Marchegiani: Thanks to all you guys have a phenomenal day. Take care.


References:

https://justinhealth.com/

https://www.evanbrand.com/

Audio Podcast:

https://justinhealth.libsyn.com/the-top-5-nutrients-to-address-gut-inflammation-and-leaky-gut-podcast-339

Recommended products:

Amino Acid Supreme

TRruKeto Collagen

TRUCOLLAGEN (Grassfed)

Probio Flora

Enzyme Synergy

Betaine HCL Supreme

Genova NutErval

 

The Top 5 Nutrients to Improve Brain Function | Podcast #333

For your brain to work efficiently, it needs specific nutrients, making the food we eat vital to brain function. What types of nutrients do we need to help our brains work? 

Some foods, such as fruits, vegetables, coffee, and tea, have antioxidants that help safeguard your brain from harm. Others, such as eggs and nuts, have nutrients that support memory and brain development. You can help keep your brain healthy and boost your alertness, memory, and mood by strategically including these foods in your diet. 

Nutrition is essential for healthy brain function! To learn more about refining your brain process in memory, attention, focus, and sleep while also eliminating symptoms of anxiety and depression, don’t skip the full podcast, check out other videos, and don’t forget to hit like, subscribe button, and the notification bell!

 

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

1:43  Inflammation in the Brain

3:50  Improving Brain Function

7:41  How Food Affects Brain Function

11:24 Insulin Resistance on the Brain

24:11 Improving Blood Flow in the Brain

27:16 Glutamate Issues

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Dr. Justin Marchegiani: Hey guys, it’s Dr. Justin Marchegiani here with Evan Brand in the house. Today, we’re going to be talking about the top five nutrients to improve your brain function. Really excited to dive into this topic today, it should be a good one, Evan, what’s happening, man?

Evan Brand: Oh, not too much been reading about some of these herbs. And these are something that we do personally. And clinically, I just want to point that out from the beginning. The difference between you and I and conventional practitioners is they’re not taking the drugs, they’re not experimenting with the stuff they’re prescribing. They’re not putting people on the depression drugs and the beta blockers and all of that, and the Adderall and vyvanse. And all the cognitive enhancing drugs, they’re not doing that themselves. So the cool thing about us is that we believe in what we do, and we want to try these things and see how they perform on us. And what if we mix it with that nutrient? How does that combine with this diet approach? And how does that combine with good sleep and good sunshine. So I think it’s fun, because you and I have personal insight into these things. And not just the clinical insight. And that really, I think makes you a better practitioner, but it makes you make a better protocol, because you know, how you feel. And then you can then tweak the nutrients based on that.

Dr. Justin Marchegiani: 110%. So I mean, I think, based on our clinical performance, I mean, just kind of, we always start with the low hanging fruit. So like if people are coming into the show when they you know, want a lot of the nuance, more granular stuff, right stuff. And that was we’ll talk about that too. But we also have to make sure people that are coming in, that don’t have a good foundation, we have to assume that foundation is not there. So of course, getting inflammation in the body down in the gut makes a huge difference, because inflammation in the gut will create inflammation in the brain. And inflammation in the brain will activate certain immune cells in the brain, right. So you have these astrocytes, which are like that make up the blood brain barrier, which prevent things on the inside going into the brain right outside going in. So if you can have good blood brain barrier, that’s important. And then once you get things going into the blood brain barrier into the brain that’s going to activate these cells, these immune cells called micro glial cells, and these are basically part of the brains immune system that go in there and clean up inflammation and gunk. And the when those brain cells or immune cells are activated, those microglial cells are activated, that’s actually going to create cognitive issues, brain fog, and things like that mood issues. A lot of the new wave of antidepressants and mood medications that are coming out are actually working on brain inflammation. So we know inflammation plays a massive role. And the hallmark of inflammation is going to be cytokines interleukins, c reactive protein, maybe other inflammatory metabolites, nuclear factor Kappa beta, of course, um, you know, part of the inflammation is going to be in activation of the immune system on one side, and usually their cells that are going to be broken down to the faster rate than they’re building up, whether it’s inflammation from bad foods, excess omega six junky fats, trans fats, hydrogenated oils, pesticides, mold, toxins could be bacterial toxins, mycotoxins from fungus and yeast, acid aldehyde, from alcohol and yeast by products. So all of our gut, bacteria, yeast, parasites, all of these things are going to create endotoxins, or internal toxins, endogenous toxins in the body. And then of course, we have exogenous toxins in the environment, like our mold, heavy metals, pesticides, chemicals like that plastics, xeno, estrogens, all of these things are going to be in the environment, of course, all the foods we put into our body. And then of course, the more nutrient poor our food are, right? The more nutrient poor our food is, the more crap in the more junk, the less nutrients you have to run those metabolic pathways to run optimally.

Evan Brand: Yeah, great job laying the groundwork, as people coming in are gonna say, Well, why why do we need a whole podcast dedicated to improving brain function? And the answer is because we’re up against so much. So you did a great job kind of highlighting that it’s the food, it’s the air, it’s the water, it’s the heavy metals, it could be the silver amalgam fillings in your mouth. I mean, there’s a lot of things that are in our environment now that are neurotoxic. They’re not just highly estrogenic and endocrine disrupting, but they’re also neurotoxins. And we’re breathing them in every day. And you and I’ve measured hundreds, if not 1000s, at this point of clients around the world. And I’ve seen children as young as two and three years old with massive toxicity from gasoline additives to thau, late to xylene, to nail polish chemicals and hairspray chemicals, and to 4D and glyphosate. I mean, it’s amazing just how toxic people are. I would tell you just based on looking at this clinically, the most toxic people on the planet right now according to me running all these labs would be children less than age 10. And I think it’s due to just the toxicity of the planet that’s increased, but also this maternal transfer through breast milk and through the placenta. All the women that grew up in the 70s and 80s and 90s and now 2000s that are having children, that multi generational toxicity really built up, whereas someone like my grandparents, and you know, growing up in the 1940s, glyphosate wasn’t even around for the First 30 plus years of their life. So yeah, there was a lag, basically. And yeah, the lag has caught up.

Dr. Justin Marchegiani: Exactly. And there’s a lot of environmentalists out there that are, you know, talking about co2 and things like that. Well, co2 is plant food. I mean, I really wish the conversation about the environment really switched to pesticides, and xeno estrogenic compounds, I think these one they’re affecting us, they’re getting into our groundwater, they’re getting into our food, they’re affecting our kids, you know, much more than like, let’s say co2, wood, right? Because I mean, you can just grow more plants and more plants around you to, to take in and basically, you know, use that co2 for photosynthesis to make glucose and, and for plant fuel, essentially, but things like toxins, right? I mean, you need to actually there’s nothing in nature, that’s going to be buffering that, like, I know, plants buffer co2, right, I’m not aware of it. And so we have to use special filtration, whether it’s air filtration, like for instance, and Evans situation, Evans, very sensitive to fumes, incense, so he has a really good high quality Austin air filter with activated charcoal with zeolite and impregnated potassium iodide to filter a lot of those volatile organic compounds out or if we’re using something on the waterside, we’re using a really high quality carbon or reverse osmosis filter to filter out pesticides and chemicals and pharmaceutical drugs that are actually in our water. So we actually have to go through extra modalities and methods to filter these things out, I’m just far more concerned about these things, then, you know, more natural forming things. So I hope that conversation can shift because it plays a big role on our mood, and our energy and our brain performance. And so kind of switching things back to our brain function, getting inflammation dialed in. And of course, I talked about nutrient density. Why is nutrient density important? Well, B vitamins are the low hanging fruit for brain function. Okay, and B vitamins are going to be the highest and high quality animal products, especially animal meat. And then of course, our high quality vegetables. So that’s to be in my opinion, the foundation of our diet is kind of this really good paleo template that focuses on lots of good healthy plants, and lots of good healthy fats and animal products. And ideally getting more of our fats from healthy animals, saturated fats and plant fats because animal fats are much more stable due to their saturated nature, right? plant fats tend to be a lot more unsaturated monounsaturated, and they can be more heat unstable, right? So the best plant fats that are out there are going to be your extra virgin olive oil, your avocado, your palm oils. And of course, the the hallmark of plant fats are going to be your coconut oil because it’s saturated, which makes it a lot more heat stable. And then of course, our if we can tolerate high quality grass fed butter, high quality, ghee, or duck tallow or beef tallow, good, high quality saturated fats on the animal side are going to be great too.

Evan Brand: Yeah, I mean, hate to call them out specifically, but we’ve seen it clinically, the vegetarian vegan people, they have a harder time with brain function, not only brain function, but mood issues, you and I’ve done podcasts on depression, we’ve done podcast on anxiety, due to the lack of the good fats in general, unless they’re trying really hard, we’re going to see this issue with poor cognitive function much, much worse and vegetarian vegan clients. And we’ve actually had some clients that have went back on meats and good quality fish and eggs, because their brain function was so poor, they were literally failing at work. And I had a couple people who were at potential job loss because their cognitive function was so bad after getting off of good meats and fats, and just going with just plant foods, they literally had to for their brain function, I was of course, very happy to see them perform better will make out those good fats back in.

Dr. Justin Marchegiani: 100%. And of course, they just kind of a little crash course and organic chemistry, saturated fats, they there’s the bond in between the carbons, so you have a carbon, and then the other carbon that’s connected to this a single bond, right, so it goes carbon, carbon, carbon, carbon. And so for instance, like medium chain triglycerides are fats that are between six and 12 carbons, right. And like butyric acid butter, I think, is around four carbons. So imagine, you know, six or 12 carbons, they’re all going to be connected with single bonds in between, which means the outer edges are going to have three hydrogens or the inner part of the bonds are going to have two hydrogens attached to it. Again, all you have to know is the difference in the bonds. So saturated fats have single bonds, which make it more flexible and ability to withstand higher heats. poly unsaturated fats, right, omega threes or omega sixes, right? The omega refers to how many double bonds there are in in the fatty acid chain. So omega threes have three double bonds, omega sixes have six double bonds, and when you have double bonds, they’re they makes the fat more inflexible, and makes it more a lower smoke point, meaning it can oxidize and it can go bad. And so just no saturated fats don’t have the double bonds, and it’s going to make it a lot more stable. And why is that important? Because our brains like 70%, fat and cholesterol. So if you’re not eating the right ratio, and the end the good raw material building blocks for your brain, you’re gonna have a problem. And every cell in our body has a what’s called a lipid by layer. So you have this little fatty lipid layer on the outer part of the cell. And if you start making or Start using junky fats to build that layer of backup is going to stress out your antioxidant reserves. And you’re going to build really inflexible, non healthy non-communicative cells with very inflexible cell membranes.

Evan Brand: Yeah. And how does that manifest? Well, that’s where some of the memory issues pop up, you freak and your best friend’s name, you go into the pantry, you don’t know why you’re there, you figure you forget which way you’re supposed to turn. When you get off the highway off the exit, do I go left? Do I go right? Even though you’ve been that way before, maybe you slip up on someone’s name, maybe at work, you’re slipping up in a presentation, you completely get sidetracked and you just can’t get yourself back on track. Maybe you’re unable to read, maybe you’re unable to retain the information you read, you have to read things multiple times. Maybe you hear someone like Hi, nice to meet you, john, and you immediately forget his name, that kind of stuff. Those are things that we see. It doesn’t necessarily have to be Alzheimers or dementia level to be considered a cognitive problems. So when we say cognitive problem, like everything else, there’s there’s a spectrum, you have the far end, which is going to be your clinical diagnosis of dementia and Alzheimer’s and whatever else Parkinson’s, and then maybe you have like your brain fog, forgetfulness, memory issues. And I’m not saying that those people with those mild brain issues are all going to end up demented. But it’s important to recognize those things now. So that we can do what we can, like you said to reduce inflammation to try to preserve the neurotransmitters in the brain. So let’s go into the nutrients if you’re ready.

Dr. Justin Marchegiani: Yeah, let me just hit one more things. We’re talking about diet, right. And one of the big things when people have chronic health issues, what tends to happen is we have insulin resistance, okay, where the cells become numb to insulin, insulin basically helps glucose get into the cell, it also helps protein get into the cell. And when insulin becomes resistant, it’s going to start taking a lot of the glucose and converting it and storing it as fat. Now that’s kind of in the body. Now what’s happening in the brain, insulin resistance will manifest in the brain through our brain not being able to use glucose for fuel. So it’s like you can have a lot of glucose in the bloodstream, but the brain is not going to be able to use it. So it’s like the brain starving nutritionally, to be able to use glucose for fuel. And so you start to form inflammation in the brain and a lot of plaquing in the brain. Now, the same enzyme that helps break down insulin is called insulin degrading enzyme. That enzyme when there’s lots of insulin around gets wasted away dealing with insulin. The problem is that insulin degrading enzyme has dual purposes, it can go in and clean up plaque in the brain. So it cleans up the brain, it’s the vacuum cleaner for your brain keeps the brain free of plaque. We know plaque has a negative impact on cognitive function and performance. And also when you become more insulin resistant in the brain, it’s hard to use glucose. So starting to decrease insulin allows the brain to also switch hit and start using ketones for fuel. And ketones are very people that have brain issues. That’s part of the reason why they’re reversing Alzheimer’s with ketones. So the first thing we do is we we don’t add ketones in our body, we switch our body’s insulin levels by restricting excess carbohydrates or our body can make ketones and start utilizing ketones for fuel. That’s just kind of first step out of the gates though, because if we have this physiology there, where we’re insulin resistant, and I’m recommending extra B vitamins, or extra gingko, or extra bacopa, man, I mean, you’re not fixing any issues, right? You’re not you know, you’re not fixing anything, you’re not getting to the root underlying problem.

Evan Brand: Yeah, well said and then I guess that would also give people a false sense of hope. And then they would come back to you and they’d be disappointed because they’re insulin resistant, but yet you’re giving them all these good brain nutrients and maybe they only had 5% improvement.

Dr. Justin Marchegiani: Exactly. So you have to make sure the brain is able to utilize the fuel in the body already. And we have to switch out you know, the insulin resistance so the the parts of the brain that are utilizing insulin and breaking down insulin can actually go in and clean up the brain instead. That’s very important.

Evan Brand: Yeah, well said I mean, that’s the important fat you know, foundation framework, whatever you want to call it, because it’s impossible to circumnavigate that issue by just supplementing like you said bacopa. 

Dr. Justin Marchegiani: Exactly, exactly. So a couple of my favorite things out of the gates like I mentioned, are going to be high quality methylated B vitamins you know B one, B two B three which are going to be thiamine riboflavin, niacin, pyridoxal, five phosphate, right which is B six pens authentic acid, which is B five, I think B7 is bioten. Right and then B nine is going to be folate and then your B 12. Make sure it’s either methylated hydroxylated or, or Adenosyl B12, which are excellent sources of B vitamins. So those are going to be great out of the gates. Outside of that things that support acetylcholine are going to be excellent. So either taking acetylcholine or using an herb called huperzine huperzine. A is is excellent at supporting that thing here. A couple of the things that um, acetylcholine really is very it’s, it really improves the colon ergic neurotransmission, which it basically helps with cognition, decreases the decline of cognition. Anything else you want to say on acetylcholine or huperzine out of the gates?

Evan Brand: Yeah, I’ve played with acetylcholine a lot. It’s kind of the Forgotten neurotransmitter, I think you and I’ve done a great job of kind of highlighting this. You know, we’ve hit on dopamine, we’ve hit on serotonin, we’ve hit on GABA, but man, you rarely have people talking about acetylcholine. So it’s, it’s probably easier to work in this mechanism, which is the huperzine is inhibiting the brain time from breaking down-

Dr. Justin Marchegiani: So the acetylcholinase, acetylcholine, acetylcholine esterase, which is going to be you know, it’s an enzyme because the ASC that what breaks down acetylcholine, so it’s slowing down the breakdown. And again, [inaudible] something we find in liver, egg yolk, so it’s really important in like high quality animal products, and we’re basically slowing the breakdown.

Evan Brand: Yeah, so you can do both right, you can come in with the good foods and good fats, and then you can try to slow the breakdown of that gland. It’s pretty cool. So there are a couple papers on this huperzine. Specifically, they talk about it, modifying the beta amyloid peptide processing, reducing oxidative stress. Also, they talk about helping with the secretion of NGF, which is nerve growth factor. So that’s really cool. And then it says here, finally, this is the research paper. Finally, huperzine a can significantly improve cognitive function in patients with mild to moderate vascular dementia. So that’s pretty impressive. And I personally just take this on going, I’m not necessarily fearful, but I just want my brain to function the best. So I do supplement on and off with some of these brain nutrients we’re talking about.

Dr. Justin Marchegiani: Right. And it also helps improve mitochondrial function in the brain. So we have mitochondria in every cell, I think except red blood cells, right. And basically, the mitochondria is the powerhouse where it generates ATP. And that’s really important fuel source. And so, one, it’s neuroprotective. So if you have chemicals or not so good compounds floating around the brain, mycotoxins whatever, it’s kind of protected from being damaged. And it’s also going to help the mitochondria the brain to generate ATP. So that’s important, too.

Evan Brand: Let’s talk about the next one on our list here, the EGCG, which is going to be the poly phenol coming from green tea, because this is really cool. The study here talks about the enhanced transport of huperzine is possible with the egcg. So they found that when they were able to stack these two nutrients together, you get even more bang for your buck, which is what we find a lot with nutrients. When you and I are working on gut infections, right, we’ll find that the individual parts are not as valuable as the sum when you combine this herb with that herb and that with that, you get a much more synergistic, I would guess you would call it an exponential beneficial effect. Right?

Dr. Justin Marchegiani: Exactly.

Evan Brand: We got wild blueberry next on the list. Let’s talk about wild blueberries. So there are some cool antioxidant benefits here. But there are some papers-

Dr. Justin Marchegiani: I wanted to highlight one thing on the egcg, right, it also helps reduce the beta beta amyloid plaque accumulation. So we talked about that, right? Because insulin resistance plays a big role because that insulin degrading enzyme, which is depleted when you have insulin resistance, that’s there to help decrease beta amyloid plaque. And we know that the beta amyloid plaque is going to be reduced when we’re taking egcg is due to its anti inflammatory and antioxidant effects.

Evan Brand: That’s awesome. All right, let’s go back to the wild blueberry. This one’s cool, too, some cool papers on this in regards to being a potent antioxidant. They have done some animal studies on this to help increase the capacity of neurons to maintain proper functioning through the aging process as also reduces some of the beta amyloid plaque aggregation. It also talks about how of course the mitochondrial function is disrupted, and the wild blueberry extract helps to protect against that. And then also, guess what, this is cool. It also leads to higher production of glutathione. So that’s a pretty interesting little mechanism.

Dr. Justin Marchegiani: Yeah, very interesting. I mean, a lot of those compound gluta phones are really powerful antioxidant. So again, they’re gonna still have like a good anti inflammatory kind of benefit. And again, you can get some of these benefits by just eating a handful or two of organic blueberries a day, which is going to be really helpful by drinking a little bit of green tea. So you don’t have to supplement these things all the time. You can also try to get them in Whole Foods sources. And again, it helps with mitochondrial function, it’s going to help in decreasing a pop ptosis and cells kind of dying on their own. And like you mentioned, natural acetylcholine esterase inhibitor. So it helps acetylcholine increase and like you mentioned on codifier on so I like that a lot. I wanted to bring one other thing in here is Lion’s Mane. Lion’s Mane is a medicinal mushroom. But it’s well it’s well established to be super helpful. It was so as Reishi as well Ganoderma lucidum. That’s Reishi. Lion’s Mane as well as very helpful on cognitive funk function. So it’s going to help with a lot of different things. It helps with antioxidant, it’s what’s known to be helpful in improving cognitive performance. It’s known to be helpful at repairing brain cells. And again, just 20 or 30 years ago in medical school, they would have taught their medical students that the brain can not repair When you damage a cell, that’s it, it’s done. And we know today that cells can actually recover and improve. So one of these mushrooms is going to be a great thing out of the gate. So big, big fan of lion’s mane, it’s shown to be protective against dementia as well, which is awesome. It stimulates brain cell growth, which is awesome. It’s also has some really improved and excellent benefits regarding depression and anxiety and mood. It helps with injury recovery. So it has some anti inflammatory kind of benefits as well. Couple of studies where they did damage to, I think it was rats or mice, spinal cords. And then they looked at the growth and the recovery on it. And they saw that when they gave these little rats Lion’s Mane mushroom that reduced recovery time 20 to 40%. And they saw that Lion’s Mane extract may also help reduce the severity of brain damage after a stroke. And in one study, the lion’s mane extract was given to rats immediately after a stroke helped decrease inflammation and reduce the size of the stroke related brain injury by 44%. So big, big fan of lion’s mane and medicinal mushrooms, for sure.

Evan Brand: And can you believe that’s not happening in standard practice right now in the medical facilities? I mean, if you have a stroke today, you’re going to go into the hospital, and then they’re going to give you peanut butter crackers for lunch right after.

Dr. Justin Marchegiani: It’s unbelievable. Yeah, I mean, they should be doing hyperbaric oxygen, they should be doing Lion’s Mane they should be doing maybe progesterone therapy, which is helpful. They should be doing like a lot of the antioxidants and glutathione and nutrients that we just talked about, right? They’re not and it’s just, it’s frustrating, because all these things are in the scientific literature, but you know, conventional medicine unless they can patent it or make a drug out of it. You know, they’re not really interested. Yet everyone thinks that, hey, they’re giving you the most cutting edge care possible? Probably not. We know this is all in the literature. And so it’s out there, it’s just you know, we all have our biases, and we’re all about utilizing all the options that are there. And there’s so many natural options that have been around for so long, like medicinal mushrooms are used in oriental communities for for very long periods of time. Rishi courtice apps, my talkie, very good immune boosting immune enhancing benefits. So I like that.

Evan Brand: Yeah, I’ve been taking Lion’s Mane for several months, it’s been a big help. I actually had a female client who she had a chronic tongue burning issue. This was one of those guests in Czech type things, and it actually works. So she had some sort of a dental procedure. I don’t remember exactly what but we believe that was some nerve damage. And so she had literally chronic burning of her tongue 24 seven, she was just absolutely miserable. We got her on lion’s mane. And within two months, she had 75% reduction in the burning tone. So that was one of those random guesses and checks and it happened to work. So we’re luckily we’re keeping her on it. And she’s maintaining her benefits.

Dr. Justin Marchegiani: Yeah, can modulate the immune system, it can also help decrease inflammation. Also, there’s studies on Lion’s Mane helping with diabetes, and we know diabetes. And that insulin degrading enzyme helps to remove plaque in the brain. So we know that the blood sugar component of lion’s mane, maybe part of the reason why it’s helping cognitive function.

Evan Brand: Yeah, and there’s a lot of anti cancer benefits to a lot of these medicinal mushrooms you’re talking about too. So we’re both huge fans, we love them, we take them. And you probably should, too, if you’re listening. And these are supplements that are not super expensive. I mean, you’re talking maybe 50 bucks for a really, really high quality version.

Dr. Justin Marchegiani: Yeah. And then also a lot of these met the the big mechanism you’re going to see across the board is you’re going to see an acetylcholine mechanism, you’re going to see an antioxidant mechanism, right. And so usually when you see the ability to reduce oxidative stress, you also see that the ability to reduce inflammation because when you reduce inflammation, inflammation drives oxidation. So oxidation is when you lose electrons. And so a lot of these compounds like lion’s mane, they have antioxidants in them. Usually they have a clue to fire and supporting effect. And then that helps buffer the oxidative stress because antioxidants come in they freely donate their electrons. So when electron pair is removed, that can create oxidation. And these guys come in there and they donate electrons freely and stabilize those cells. And that reduces oxidation. And that reduces inflammation. So that’s pretty powerful, and so very helpful with inflammation and oxidative stress in the brain.

Evan Brand: Let’s hit on another mechanism. It’s about improving the blood flow in the brain. We know that gaesco which is amazing. Gingko has some what they call like microcirculation in the brain improvements. I love gingko I’ve played with a lot of gingko and used it and they’re amazing, beautiful trees. If you’ve seen the Leafs of them, they’re very, very cool actually found my old property actually found a rock that was like a fossil with well preserved gingko leaves in the rock. It was super cool. So gingko is like one of the oldest trees it’s been around hundreds of millions of years. But on that same vein of cerebral blood flow, you’ve got the vinpocetine which comes from Periwinkle flower. And that’s really cool because it’ll actually cross the blood brain barrier. You know, there’s, there’s a lot we talked about, and but the truth is you got to get the nutrients across that barrier if you really want the benefit. So there’s a lot have different studies on dementia related issues and vinpocetine, quote, producing a significantly more improvement with memory problems than placebo on global cognitive test regarding attention, concentration and memory, it talks about increasing the cell membrane flexibility and stroke pay since it talks about decreasing platelet and red blood cell aggregation. It talks about protecting neurons from toxicity of glutamate. So this is a very cool nutrient.

Dr. Justin Marchegiani: Exactly. And you mentioned the bacopa. And they’ve been post a teen, they all have blood flow enhancing effects. And we know inflammation causes increase aggravation of red blood cells and platelets. And that can decrease blood flow and blood flow is going to carry oxygen and it’s going to carry nutrients, right. And so the more we can decrease inflammation and get nutrients up to the brain, you’re going to feel better, and you’re going to do better, right. And then you mentioned a lot of the big benefits are going to come from antioxidants, effects, they’re also going to come from the protection of neurons. So if we have any type of inflammatory or toxin around it, is going to help those neurons and prevent them from dying, right, which is really important. And then also just to highlight, there’s a lot of studies on gluten actually decreasing blood flow to the brain. And we know blood flow is a really important component. And there was, I think, one study on migraines and they found that you know, the garden hose is the carotid arteries that go up the side of the neck here brings blood up to the brain. And in patients that were consuming gluten, they found that there was a decrease in blood flow. And then this one group, I think they restricted gluten and they saw 90% of them nine out of 10 and your migraines went to zero, and they saw an improved blood flow up to the brain. So we cannot you know, underestimate the the effects of kodagu ability meaning reducing coagul ability clotting and increasing blood flow, better blood flow, better nutrition and that can have major effects on the brain. And we know things like gluten and anything more on the inflammatory side will impact that on a negative side on the on the negative fashion.

Evan Brand: That’s amazing. It’s like you should go to the restaurant and they’re going to give you the gonna give you the bread or give you the bun. Yeah, here we’re going to reduce your cerebral blood flow. Are you ready for this? Oh, sure. I would love to reduce my examination to my brain.

Dr. Justin Marchegiani: Exactly. And you mentioned like a lot of the glutamate issues and how that’s going to be part of that inflammatory cascade. And we know glutamate is shown to be an excitotoxin so it really overstimulate cells to the point they die. And so of course, decreasing that gluten exposure and decreasing that glutamate and that and MDA, which is going to be stimulated by that glutamate, which is going to overstimulate ourselves and cause them to die. That’s a problem. And so we know a lot of these compounds, right? [inaudible] bacopa, are a neuroprotective and they’re also going to help with blood flow. So that’s a good component out of the gates. And I would say next would be one of my favorites, serotonin and dopamine support. So I have a product called brain deplete that has dopamine or tyrosine. And it’s also gonna have five HTP and some of those key B vitamins out of the gates. I think those are kind of low hanging fruit because those amino acids serotonin and dopamine, which are going to be building blocks of tryptophan and five HTP, and Tyrosine and phenylalanine, they’re really important for serotonin and dopamine, which have a lot to do with sleep and recovery. And serotonin is a powerful precursor to melatonin, which is a powerful antioxidant. And then of course, dopamine is a powerful focus and brain enhancing kind of effects. Right? Don’t means focus and feel good. I love you that good feeling of satisfaction and helps with really focusing and studying and learning. So dopamine and serotonin and have major important benefits on brain health.

Evan Brand: Yeah, and we’re in a very chronically low neurotransmitter population. And I mean, Doug, look at the way society performs. Look at our everyone’s addicted to everything addictions come from low dopamine. So you’re constantly refreshing your Instagram, you’re going to this social media, then that one, I mean, that’s kind of a low dopamine state. And you and I have the data to prove this is not just theory, you and I’ve looked at 1000s at this point of organic acids test, and I will say probably seven out of 10 people I’m looking at, they have sub clinical, I guess you would call it it’s not like a pathological level. It’s not like a, you know, Parkinson’s type level, but they’re going to be on the low dopamine side, and we can boost this back up. So the fun part is helping people to reverse this stuff. So I want to just, you know, wrap this thing up and tell people that you can reverse a lot of your cognitive problems, and most people don’t even know how brain fog they are until they truly get better. So clearing out the garden infections, cleaning up the diet, reducing inflammation in the gut getting rid of Candida that’s producing the aldehyde you talked about getting rid of the lightbulb polysaccharide production, getting rid of any kind of toxin that’s internally pooping in you essentially getting rid of those toxins, plus dialing in the diet plus the nutrients while you can improve brain function 300%. 

Dr. Justin Marchegiani: I mean, it’s totally possible 100% and the only other X Factor should be if we have to work on detoxification of mold or heavy metals. There are special compounds that we would use, whether it’s glutathione or various binders, beet root extract activated charcoal zeolite fulvic minerals. Maybe if we’re doing heavy metal, we may use things like dmps or HLA or cloudify on so it depends when it comes to a lot of these more intense detoxification programs you want to make sure you’re healthy enough you want to work with the practitioner to make sure that you’re in a stable place to be able to handle that it wouldn’t be something that would say hey, you want to improve your brain function just knock these things down right away because you may actually feel worse. You want to work on the foundational things the low hanging fruit and the maybe some of the more I don’t know more general support that would be helpful like B vitamins or Lion’s Mane or some of those herbs that aren’t going to have a over a detoxifying effect if you will.

Evan Brand: Yeah, good call. I mean there is a point where you need a practitioner the line brain the mold, brain bartonella brain I mean some of these bigger complex 

Dr. Justin Marchegiani: Chronic infections, infections for sure. 

Evan Brand: They get intense so if you do need help, please reach out you can reach Dr. J at JustinHealth.com and you can reach me at EvanBrand.com and we would love to talk with you about this figure out what’s going on with you and see if we can help.

Dr. Justin Marchegiani: Absolutely, if you guys enjoyed it, give us a thumbs up click down below our links where you can give us a review. EvanBrand.com/iTunes, JustinHealth.com/iTunes for that review, put your comment down below. I’d love to know your experience and kind of you know, applying some of the things we’re talking about and to give us some feedback on things that you’re already applying in what you’re seeing improvements in your health. We really appreciate it. It gets us excited.


References:

https://justinhealth.com/

https://www.evanbrand.com/

Audio Podcast:

https://justinhealth.libsyn.com/the-top-5-nutrients-to-improve-brain-function-podcast-333

Recommended products:

Brain replete

Serotonin replete

Dopa replete

Antioxidant Supreme

TruKeto Collagen

TRUCOLLAGEN

Organic Grass Fed Meat

The Root Causes of Constipation & Slow Motility | Podcast #331

Wouldn’t it be easy if you could blame your constipation on one thing? While that typically isn’t the case, your irregularity could be pointing to either one or multiple causes. Let’s watch and listen to Dr. J and Evan here, helping you learn what your gut may be trying to tell you, and what you can do about it. 

Dr. J and Evan emphasized to make a few changes to your lifestyle and see if they result in any positive bowel changes. Such as more high-fiber foods in your meals: fruits, vegetables, whole grains.  These steps will help you observe health changes – what works and what’s not via tests results as well.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

1:56       Slow Motility, Bowel Motility

8:06       Detoxification

15:57     Food for Detox

22:00     Vegan Honeymoon

27:40     System Approach, Solutions

30:51     Conventional Side

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Dr. Justin Marchegiani: We are live. It’s Dr. J here in the house with Evan Brand. Today we are going to be having a podcast all about constipation and bowel motility issues. This is a topic that we deal with all the time with our patients, especially when we’re dealing with and addressing potential infections. This can be a common side effects. So we’re going to dive into the underlying mechanisms and what you can do what we do about it with patients. Evan, what’s going on, man? How we doing?

Evan Brand: Doing really well. If someone listening is still embarrassed to talk about their poop, then I would encourage you to shed that shit shed the shame or embarrassment. We talk about poop all day. We love it, we enjoy it. This is part of being a human number one being a healthy human number two, because if you’re not pooping, you’re reabsorbing toxins, whether that’s xeno estrogens from environmental exposure or pesticide and herbicide or mold toxins, I mean, how we get rid of our toxic waste and chemicals and things we’re making internally and that we’re exposed to is peeing and pooping. And so when you look at someone who feels bad, they have dark circles under their eyes, they have skin issues, they’re irritable, they’re fatigued, they have headaches, a lot of times constipation is one of the underlying issues with those people. And if we can just get them pooping properly good amount in good shape, good size, good consistency, good frequency, we can really increase their productivity, their energy, their mental cognition, we can get rid of sugar cravings. I mean, there’s a lot that can happen when you just regulate the bowels. So we’re going to dive in today on some of the big root causes root triggers, I’m going to go straight to number one for me, which is going to be gut infections. Now, you and I were just talking before we hit record about different gut bugs and how some people with IBS, they’ll end up IBS constipation, others end up IBS D diarrhea. And so depending on what type of infections you have, your bowels may become dysregulated.

Dr. Justin Marchegiani: 100%. And so, when you have different gut stressors, slow motility can easily be a result. So you can easily see on the on the fast side, motility is too fast. Our body doesn’t have the ability to reabsorb water and electrolytes in time, because usually electrolytes and water kind of follow each other. So as the colon kind of pulls out the electrolytes, usually the water comes out with it. And so when we have slower bowel movements, right, they’re usually harder, more compact kind of stools. So if we look at like, for instance, the Bristol stool chart, I’ll pull that up on screen. So anyone that’s watching the podcast can take a look at it. The Bristol stool chart, the chart that’s used by gastroenterologist and such, but it’s just a way of kind of assessing where you’re still fit. So the typical number four is like the poopy policeman. And that’s like just a really good solid looking snake, like not overly hard not overly soft stool. That’s number one. If you go to the actual number one on the Bristol stool chart that’s like kind of the rabbit poop, right, the rabbit pellets really hard, hard to move. And then number seven is just pure liquid. So four is kind of right in the middle, and in between. So let me just show you what I’m talking about here. So you guys can visualize if you’re watching the podcast video along with it. So here is the Bristol stool charts that you guys can see. Okay, so number one, right separate heart clubs, nuts hard to pass. This is like the rabbit poop, right? That’s type one. And then it gently progresses back to two and three, right? where it starts to get more sausage shaped like it says except it gets more smoother, and that as it goes to three. And then step type four is the perfect poopy policeman kind of more of a sausage like more smooth, not overly cracked or not overly soft. And then you can see as you go to five and six, it becomes more liquid and then seven and just entirely liquid watery, no solid. And so that gives us a pretty good window. And so we usually when we have when the guts really inflamed, and we have usually a lot of toxicity in the gut, we can usually see it go to number seven where it’s pure liquid. And that’s because the body is just trying to flush things out. And when things go a little bit slower, you could still have inflammation and have type one right so you could have h pylori, that’s lowering stomach acid, you could have a lot of cebo that is meth that’s producing a lot of methane based back gases. And how do you know it’s methane is you have a lot of foul smelling gas or flatulence that’s a sign that there’s a lot of methane present. And methane can easily screw up that migrating motor complex and make the bowels go more on the slow side. But you can have the same level of infections like h pylori, or maybe histo or Giardia. And that could also cause it to go on the diarrhea side. So it just kind of depends. Everyone’s a little bit different. But we always you could have cebo you could have h pylori, you could have low enzyme and low acid levels that can easily be causing type one. But for someone else, those same infections could easily be driving steps type seven, right where it’s pure liquid. So you got to look at everyone as an individual on that. And really, you know, come up with the right plan.

Evan Brand: Yeah, and it can Alternate to write. I mean, that was my situation when I first had gut issues and I was losing weight uncontrollably when I had H. pylori and parasites and bacterial overgrowth and Candida the whole nine yards. You know, there’d be some days the gut was good. And most days the gut was not good. Luckily, I’m over that now. But man, I’ll tell you, I have a lot of empathy for people that, you know, you never know what you’re going to get, you kind of wake up and it’s like, Is today a good day or not a good day. And now that I’ve learned so much, you and I, both over the past few years about mold toxicity, that’s a big trigger for gut issues, too. So I’m get constipated, but a lot of diarrhea. And I think that’s the body’s way of trying to get rid of the toxin, but also the gut is so irritated. And you can have leaky gut from mycotoxin exposure, that that can be a factor too. So eventually, we’ll get into the gut healing phase of our conversation. I think that’s critical to healing constipation.

Dr. Justin Marchegiani: 100%. And so on the constipation side, there could be issues with obviously, the bowel motility has to be slow. So what’s constipation. So if you’re not having a BM, you’re not passing about 12 inches of stool in about a 24 hour period. That’s typically constipation. And there are millions of people in this country that aren’t able to have a BM every day. Now, once you start going 2 3 4 5 6 7, I see some patients that go up to seven days about a BM, that’s a problem because half of your stool is going to be bacteria. The other half is going to be you know, fiber and such. And within that stool, some of that bacteria and toxins needs to leave your body. If you’re not having that pass through your intestinal tract into the toilet, your chance of reabsorbing a lot of those toxins goes up really high. That’s definitely not good. Because those toxins get reabsorbed into your body. There could be xeno estrogens, there could be mold toxins, there could be a whole bunch of junk in there that you could be reabsorbing, and that could be really stressing out your body. So the first thing we talked about with detoxification is people talk about Detox Detox Detox, right? Well, if you’re not pooping every day, and that’s because of a gut infection or not chewing your food well enough or having insufficient hydrochloric acid or enzyme levels, or having some kind of a h pylori or SIBO issue. All of those things can easily affect your detoxification people are really focused on detox. Just by getting your digestion and your motility better. That makes a huge difference on your liver, and all your detoxification pathways, your lymphatics, your immune everything.

Evan Brand: Yeah, it’s funny, you’ll see women on Instagram, they’re all done up their hair and their makeup and their lipstick, and they’re like marketing, hashtag add hashtag detox hashtag tea. And they’ve got these like, I don’t know, you know how it is like, these ridiculous products that they’re marketing and they’re not talking about poop. To me, that’s the best way to detox is get poop out. I’m not going to buy detox tea, maybe like a little bit of dandelion or some who knows milk thistle, blend it in. Yeah, I mean that that’s part of it. But unfortunately, detox has kind of gotten co opted by the marketing industry. And so most people don’t even focus on that, though. You know, they’ll poop once a week, but then they take a detox tea and they think they’re doing it correctly.

Dr. Justin Marchegiani: Yeah, I mean, my whole take on detoxification out of the gates is very simple. Okay, first, get enough good clean water in your system, to make sure you’re digesting your amino acids and all your nutrients. Well, remember, sulfur based amino acids run the majority of your detoxification pathways, along with B vitamins, right. So we need good B vitamins, good antioxidants, good sulfur amino acids. So if we’re breaking down those nutrients, well, there’s not a bottleneck with HDL levels or enzyme levels. We’re getting enough good clean water. And we’re not overly stressing our sympathetic nervous system because remember, the more we overly overly stress the adrenals the sympathetic nervous system decreases that migrating motor complex, which are the wave like contractions that move stool through your intestinal tract just like you kind of roll up the to pace roll at night, I get that toupees moving through to get your toothpaste out to brush your teeth. your intestines do the same thing. So if you can do those top three things, right, you’re on the right track. Now there may be extra things where we need extra sulfur or extra antioxidants or compounds or binders to help with mold or heavy metals. That’s true and that that would be addressed down the road but a lot of toxic patients detoxification happens hepatobiliary liver gallbladder back into the intestines and then out the intestinal tract. So we need to have really good motility and really good absorption of nutrients and a lot of good clean water to help fuel that.

Evan Brand: Yeah, good point. Good point. Yeah, so we both manufacture our own custom blends of supplements that are professional grade, and we both have a liver support that has some gallbladder nutrients built into it. That can be really helpful because, as you mentioned, with sluggish bowels, a lot of times there’s also sluggish bile production. So just helping to thin the bile, whether it’s using supplemental ox bile or muthoni, taurine, beet powder, whatever else we could do to increase bile flow that’s going to be helping and then why don’t we hit on the diet piece. I mean, I think this is the low hanging fruit that you’re having. American is still really really blowing it on, which is just the fact that they’re not doing enough good meats, good fats, good veggies, you know, your average, American might wake up and I don’t know, do a piece of toast and maybe in 2020, or 2021, it’s an avocado toast. But still, you know, that’s not the optimal thing for good poops.

Dr. Justin Marchegiani: Yes, so inflammation in the diet can easily mess up the intestinal tract, inflammation in the diet can easily create inflammation in the gut. And that could either move the body more to diarrhea or more constipation. Now, for the sake of this podcast, if we start moving more to constipation, not good. And of course, you know, these foods can stress out the intestinal tract. And then when we start creating inflammation in the intestinal tract, and then we already have indigestion, and we don’t have adequate enzymes and acids, so we’re kind of burping a lot after our meals, food sits longer in our tummy, right, and we’re not in a lot of gases are produced because the foods are not being broken down properly, that’s a problem. So we got to really make sure we’re masticating and chewing our food very, very, very well, we got to make sure that increases surface area for enzymes and acids to work, we also have to make sure we’re not overly hydrating with our meals. So hydrate 10 minutes or more before meal. And then if you’re consuming a little bit of liquid with a meal, just do it to kind of help with swallowing pills, don’t do it for hydration purposes. Because water has got a pH of seven, your intestinal tracts a pH of 1.5, or two. So if you start adding a whole bunch of seven, Ph to a to a pH of two, you’re going to move that pH more in the alkaline direction away from the acid at direction. And we need good acidity to help activate our enzymes and our acid levels very important. So that’s low hanging fruit is chew your food up well. Second, is make sure you’re not overly hydrating with the food do all your hydration two minutes before.

Evan Brand: I’ve got my grandfather so many times till this drink liquid with almost every bite of his food, held his Drink, drink drink, like take a bite of food and wash it down with liquid. I’m like no, like you’re literally just pouring water on your digestive fire don’t do that. So yeah, it’s it’s easy. And it actually does make a difference. I mean, you know, I’ve probably talked about that before. But it does make a difference. Like if I, I’ve got a mason jar here, my goal, if I sit at the dinner table, I will try to not have it more than like two ounces of liquid. You know, if I have a full cup, I’m more I’m liable to drink it. If I’ve just got a little bit I know, hey, this is the only liquid I have if I need a little help with the meal. Otherwise it just food, no liquid with the meal. 

Dr. Justin Marchegiani: Yeah, for me, as soon as I know, like a meal is coming, I’m gonna go just maybe take two mason jars, add some sea salt to it, I’m going to down them and then I’m good. And then you know, 510 minutes later, I can start the eating process and I chew my food out very well. So then that gets the digestive juices rolling as well. So on top of that another low hanging fruit is let’s say you eat good quality proteins or fats, and that makes you constipated. That’s almost a surefire sign. You’re not making enough enzymes or acids. So some people they really do poor with enzymes, and acids, and it reveals itself through animal products. Now, a lot of people when that happens, guess what their natural tendency is, unfortunately, either going to go vegetarian or yeah, oh, it’s the meat that’s so bad for my gods, the meat that’s in my intestinal tract for days and days. It’s rotting in there, you know, yeah, documentaries, I have to cut out the animal products. Well, it’s just a sign that your enzymes and your acids are really poor. And the meat is revealing that now what’s the solution? Now in the meantime, you may want to drop down some of the meat that you’re doing, or some of the protein or fat you’re doing, just to kind of lessen some of the stress off the intestinal tract. But the first thing we’ll do before that is we’ll add in some HCl and some enzymes, maybe even some bile salts, we’ll see how much that starts to correct it. And then if we need then we can drop the animal protein and fat down a little bit if we need. Now, if your intestinal tracts really messed up, you may have to do an elemental or a bone broth faster, or something more liquid based to make it easier on your intestine. So everyone’s a little bit different. And we have a lot of clinical experience about being able to meet someone where they’re at so we can get optimal results.

Evan Brand: Yeah, and it’s sad that the meat gets the blame, you know, and like you said, all these documentaries that will pop up on Netflix, they’re all like, majority, you know, anti meat vegetarian vegan documentaries, and then you kind of have to help clients because sometimes we’ll get clients that have not listened to enough of us where the we haven’t convinced them to get back on me actually had a vegan or ex vegan client come to me last week. She said she was vegan for six years. And she got back on me with the help of listening to our podcasts. And she says she feels better than she ever has, which is amazing. She was able to transition back onto me without necessarily a bunch of supplemental enzymes, but in most cases, yeah, we’re going to come in due to and people may say why why do I need the supplement? Well, we don’t live in a world where you’re sitting on the edge of a cliff overlooking a river valley with no stress. And you know, hunter gatherer average work 18 hours a week. We’re not doing that anymore. We’re working 40 60 hour work weeks. We’ve got kids, we’ve got technology we’ve got Got smartphones taking our attention away, we’re scrolling in Bowling at chipotle looking at our phone while we’re eating, or we’re stressed from bills and mortgages and obligations and whatever and age, by the time you’re age 40 50 60, you’re not making hardly any enzymes and acids compared to when you were younger. So all those factors add up that is the answer of why why do you need enzymes to support you? And how do enzymes help you poop? Well, because when that food is digesting better, your body’s going to be able to get rid of what it doesn’t need. And if you have a lot of malabsorption problems, you know, you may see on digested food in the stool. And over time, I’ve noticed people just adding in a handful of berries a day was all we needed to really clear up their their issues. Once we got all the gut infections enzymes in, you know, infections resolved, enzymes put in if they still needed help, we’ll go into a couple other things you want to get into. But handful of blueberries, I mean, that does a lot.

Dr. Justin Marchegiani: So it just kind of going back to some of the the vegan stuff. So I always tell my patients will in general, ie more non starchy vegetables, most paleo people eat more non starchy vegetables than vegans do. Most vegans I find have lots of processed carbohydrate, they have lots of grains, lots of lentils, or legumes and they don’t typically eat tons of non starchy vegetables, it’s it’s difficult. On the vegan side, most don’t do it right now, if you’re going to be a vegan, you need to do lots of good fats from avocado and coconuts. And you probably need some kind of an amino acid supplement from rice or pea protein or some kind of some kind of an algae kind of protein source because most aren’t doing it right if you’re going to do it that way. But number two is sometimes the vegetables can jack you up to especially if they’re raw, because a lot of that fiber or if the vegetables are higher in fermentable, carbohydrates, some can be like garlic and onions and, and broccoli and asparagus, they can be higher and fodmaps. And fodmaps can be fertilizer for a lot of the SIBO base bacteria. So if you have a lot of bad bacteria that’s producing maybe more methane, and some of those vegetables start to feed some of that methane producing bacteria that may make you more constipated too. So I’ve seen some patients do better more with the meats than with a lot of the plants. So I’ve seen it go both ways. And you know, it’s hard because if you’re let’s say you’re one person, and you had an experience where you went vegan, and you felt great, well guess what, you only have your experience, I see patients that have gone carnivore and felt great. And so because we have this perspective, where we’ve seen dozens of people do great from different things, that allows us to form a unbiased clinical recommendation on what we think is best for the patient, because we’ve seen successes work from both sides. And the question is, we don’t have a dogmatic belief in Oh, well, this is what does it well, this is why it would do it for this person. And this is maybe why it doesn’t for you. And we’re going to we’re going to move the levers around because the goal isn’t to do this thing is to get you the result. So it’s really important that if you’re working with someone, you know, kind of talking to patients that are out there, you want someone you want to work with someone that’s results driven, not process driven, meaning, hey, this, you have to do this diet, this is the most important thing, this should get you the results versus Hey, no, I want to get you these results, we’re going to try pulling some of these levers and see what happens as a result. And then we’ll we’ll go backwards from there. So just really important. You want to make sure you’re working with someone that’s results driven, not necessarily, you know, dogma driven, if you will.

Evan Brand: That’s another great soundbite. You’re just rolling out these things. I love it. This is exactly the point that we needed to hit on. Because in this day and age, unfortunately, everything is kind of a soundbite. So you go to the lectin guy, you’re going to get the lectin diet, you go to the carnivore guy, you get the carnivore diet, you go to the vegan guy, you get the vegan, and you and I don’t really have any labels for us, we’d like you said we were results driven. And so we’re able to be more flexible. I love that we’re not in a box, like these people, because once you write the carnivore book or the lectin book, you’re kind of that guy, and then you’re stuck in that box. And it’s like, oh, wait a second, I’ve got all these other people doing really good with some cooked lightly steamed veggies and blueberries over here. But you told me I need to be carnivore. So what the heck, and then it just blows your credibility. So I yeah, I don’t want to be in a box.

Dr. Justin Marchegiani: Now I tend to lean more on the Paleo template, but I use the word template, not diet, so I can have flexibility. And there’s some patients that I’ve seen that haven’t been able to tolerate any meat, we’ve had to just lean on free form amino acids, with some good vegetables or starches that are easy to handle. And I’ve had to go to that extreme with some patients. And if my dogma was no, you must eat animal products all the time. While I may not have been able to help that Paris person so we try to have the levers that we work with. We kind of have like a foundational bias, but it’s a bias that is flexible and that we can adjust according to the patient.

Evan Brand: Yeah. And eventually I would argue that that person you’re referring to could probably get back in and they may have been able to get back here forever later.

Dr. Justin Marchegiani: Not the case, not a forever thing. It’s kind of a starting point where, hey, you break your ankle, you probably may have to be in a wheelchair out of the gates. And then we progress you to, you know, some crutches and they put you on a boot and then you just maybe Walk slowly, you don’t run and now you start jogging and majesty, right, there’s a progression and how you how certain things heal? Well, it’s the same thing, the four year digestive system that’s not quite as outward, it’s inward, right and how it looks and performs. But you can feel it just the same as an outward injury to your foot or hand.

Evan Brand: Yeah, I’m gonna keep this thing going a little more philosophical than action based for a minute, just to to further this conversation, which is that let’s say someone goes to the bookstore. It’s funny, everything’s changing with society, isn’t it now it’s the Amazon bookstore, the Kindle bookstore, it used to be the real physical brick and mortar, there’s still a need that exists out there. I know there are some. So you go into the store, right, and you go to the diet section, and then someone picks up like, the, like I said, the Paleo book, The lectin book, The carnivore book, they do that, and then they get different or weird results. And then they kind of just give up, and that’s why they get so opposed to the word diet, or they get so opposed to the idea of changing the way they eat to change their symptoms. But the problem is, all these people writing these books are missing all the other root causes. So just because Jane didn’t do well, with a lot of meats, she might give up on meats, like you said, or she saw the documentary and give up on meats, but she never worked with somebody like us. So when we have these clinical tools that we have, where we’re going to be measuring the stool measuring the urine and looking at different infections. If we could just resolve those for Jane, get some of the enzymes back in clear the infections, guess what now she does great with the meat. So it’s sad, because there’s so many people that may have tried stuff like this, but they got so turned off with the non amazing results that they thought it was the diet to blame. But it wasn’t it was just the root causes. And like you said, the indicator is it sort of for us, it’s a clue Oh, that happens when you do meets, that doesn’t mean give it up. That means let’s figure out why. And the H Pylori could be the big one.

Dr. Justin Marchegiani: It’s true. And I call it the vegetarian or vegan honeymoon. A lot of people that do go vegan, they can feel great their first year, it all depends where they’ve come from if they ate a lot of processed food or crappy food. And they’re eating lots of organic vegetables, and maybe some good healthy or plant fats like olives, or avocado or coconut oil. And they’re just getting a lot of organic food in their system, they may feel a lot better now over time is essential fatty acids and amino acids start moving more in the deficient side. And a lot of those fat soluble vitamins like a d k start moving downward, they’ll start having more problems over time. And that’s kind of I call it the vegan honeymoon where they’re kind of chasing that honeymoon. They’re like, I don’t feel as good as I did last year. And they kind of get stuck. And usually it’s a protein, fatty acid kind of issue, or maybe even a carbohydrate issue too much carbs. And then you got to look deeper. So getting back to the constipation part right, we have the six hours that I used to work with my patients. And we kind of start with that as a framework, removing the bad foods, or placing the enzymes and acids to the first two hours. And we adjust the diet accordingly. So it could be cutting out cutting down a lot of the fiber or a lot more cooking or going lower fodmap. or cutting out salicylates or females or going on to a moon, it could be a combination of all of that could be an elemental diet, of course, adding in enzymes and acids. And bio, especially if the stools are floating more, that’s a sign that we’re not breaking down fat, so we may adjust those first two hours. And if we’re having bowel movement issues, I may add in things like ginger, or bitters or D lime any, we may have to even add in some natural things like trifle or magnesium to really get the bowels moving. It just depends. I don’t like to add in bow movers unless I really can’t move the bowels with those first two hours, right. If I can’t move the bowels with those first two hours changing the diet and changing enzymes, acids and bile support, then we may lean on things to kind of get the ball moving. But I always want to see how the body responds before we have to add those things in first.

Evan Brand: Well, you make a great point. And even clinically, the things you would recommend to be used directly for moving the bowels those things are still a hell of a lot safer and more effective than some of the conventional stuff you’re going to get. So I mean, if you go to your conventional doc and they refer you to the GI doc and you’re diagnosed with let’s say IBS, C constipation, IBS type issue, there’s going to be some type of a pharmaceutical involved and there’s likely going to be side effects with that. And once again, it’s not the root cause so in your case like you mentioned clinically, you may not go straight to the magnesium hydroxide to help move the bowels by adding water to the bowels However, there’s so many people deficient in magnesium anyway that you could be actually fixing simultaneously fixing an underlying mineral deficiency plus helping to move the bowels. So the cool thing about what we do, is there a positive side effect so we can kill multiple birds with the same stone?

Dr. Justin Marchegiani: Yes, I’d much rather use a nutrient than like an abrasive herb like Cena or Cascara Sagrada, right? No one has a deficiency of that, but they may have some deficiencies in some of these magnesium so that can be helpful. Now if I get bowels moving out of the gates, usually one or two months in, I’m going to try pulling back on some of these compounds to see if the bowels can move on its own. So it just depends, right? We’re getting the body hydrated, we’re chewing better. We’re working on eating and a non stressful environment, we’re getting enzymes and acids better. We’re cutting out the inflammation. And we may be changing some of the format, the building and the food. So all of those things are moving so many levers. So when I work with patients, patients are like, want to know like, what’s the solution for this? What’s the solution for that? It’s like, I don’t know, I’m going to just give you what I’ve seen to work. And we’re going to do eight or nine or 10 things out of the gates. And we’re going to see what works. But in general, to know exactly which one it is, it’s really hard because you’d have to like make one change, wait a couple of weeks, make one change, wait a couple of weeks. And it would take patients years to get better versus weeks and months. And so we make a whole bunch of changes at once. And then we monitor and we check in on those changes.

Evan Brand: Yeah, good point. So just to give a little more clarity, somebody who’s listening, like what does that even mean? Eight or nine changes. Oh, my God, that’s overwhelming. No, I mean, it could be Hey, look, we’re going to give a little more enzymes and acids, we’re going to pull this food out, we’re going to get you to do a little bit more water and a cleaner water source, we may throw in a little bit of this extra mineral, or maybe a little extra vitamin C, you’re going to do a handful extra of some blueberries, you’re going to make sure you’re getting enough adequate movement because you’re a sedentary job. So we’re going to get you a standing desk. And now you can stand up and move around, we’re going to get you to do a 10 minute walk a day, we’re going to get you to you know, take a couple deep breaths, we’re going to get you to chew your food better, we’re going to make sure that you’re not sitting in, I don’t know a crazy loud restaurant with like, you know, speakers blasting, you know, techno music in the background, we want you to just settle down, we want you to go to bed on time. I mean, yeah, those things give you 5 10 15%. And then by the time you add it all up, you’ve got really good success.

Dr. Justin Marchegiani: Yeah, you’re not chewing your food. I’m sorry, you’re not hydrating when you’re eating right? All these things matter. And maybe getting a little bit more sunlight, right? All these things matter. And so that’s why it’s so hard to be like, well, what’s the solution? for this? It’s like, well, there’s a lot of things that can be a contributing factor, it could be 10%, for this 5% for that 20%. For that it’s very rare that this one thing is at 90 100%. Sometimes you get big, like you just make one simple change. And you the next week you check in with the patient. They’re like, well, I’m 80 or 90% better, it’s like whoa, that’s a home run, that can happen too. But we don’t count on it. And that’s why we do things kind of in a systematic fashion of what’s going to be the low hanging fruit and then we kind of move up from there, right? You got to build up the foundation of the house once the foundation solid, now you can you can build up, the foundation is not solid, then you have a whole bunch of problems that have happened with with the building of the house as you start going up.

Evan Brand: Good point. Good point. And this is the whole reason that we do a workup and we run people through a sort of a system. You call it a system approach. Because if you come in and you go to the doc, hey, I’ve got constipation. Pharmaceutical laxative, see you later. If you come to us constipation, it’s like, Huh, Interesting. Interesting. Okay, let’s figure out why. And if you ask why enough and you do the proper testing, you’re going to get to that why. So I just want to make sure we’re always comparing and contrasting because you ask, you know, Bobby, who hasn’t pooped all week what he’s going to do for his constipation, he might go to Walgreens, he’s going to go to the laxative section. Oh, I found this laxative. This one looks good. Let me drink some of this stuff. Oh, yeah, I poked Problem solved. It’s like, huh, yeah, you solve the constipation problem, but you didn’t solve why that’s happening in the first place. So I just, it shouldn’t have to be revolutionary to think root cause, but it still is not the mainstream. So until it’s the mainstream, our job is not done.

Dr. Justin Marchegiani: Yeah. And so when for most conventional, like gastro people, for instance, they’re just like, hey, motility support, here you go laxative support, here you go. It’s very rare, you may get one that say, hey, let’s do a Siebel breath test, maybe that, and then what after that, maybe they’re gonna just recommend, hey, you know, do this quick little diet thing, because a lot of the conventional fodmap diet still have a lot of grains and other crap in there. So you may not change the inflammation. And they may throw some Rifaximin or neomycin at you, boom. And then now maybe you have a fungal overgrowth or something on the backside, because they don’t do or address the gut bacteria, right? And then that can create other rebound overgrowth down the road. So let’s say you have a very progressive kind of forward thinking gastro Doc, maybe that’s what happens that I just mentioned, but most that’s going to be hey, here’s your motility enhancer. And you know, you got to just learn to relax and meditate and hey, maybe taking antidepressant a lot of time. That’s it. So you’re kind of stuck. And that’s just the insurance space model. When you have three to five minutes with a doc, that’s typically all they’re going to recommend for you. They don’t have enough time to really dive in deeper. And that model doesn’t give them the ability to dive in deeper. So you really need to see a functional medicine doctor to really have the ability to go deeper and get to the root cause.

Evan Brand: Yeah, I get so frustrated with that term, integrative it just makes me angry because I’ve had so many people and I know you have to hundreds and hundreds and hundreds of clients and patients that have said I’ve worked with this angle. Right of guy, Mike Oh, integrative What did he do? And you know, they kind of market it as it’s like so forward thinking, but like you said, it may be the Rifaximin at most. And then guess what a lot of these people they have antibiotic resistant infection. So we’ll test them and guess what the SIBO situation is still going on. Maybe they have parasites or like you said, there’s a fungal overgrowth component to it as well, their guts leaky, their guts inflamed. Now they’ve got all sorts of other problems as a side effect of hitting this Rifaximin. In some cases, it can help maybe play whack a mole a little, it may knock some things down, but they still have enough problem when they come to us that we need further work. So I get frustrated with this integrative idea. Because and I know there’s good intention behind it. But as you mentioned, with that model, the way the model exists, it doesn’t doesn’t allow enough time and there’s not enough advanced testing, like we’re doing to to fully get to the bottom of it

Dr. Justin Marchegiani: Correct. And once you kind of talk to your conventional medical doctor, and you say, hey, walk me through your thinking on what you think the root cause of this could be. Usually it kind of reveals their that they really don’t know. Because if you’re just providing a drug to treat the symptoms, well, obviously, they’re not worried about the root cause because it’s Band Aid down below, right? So we kind of look at everything in my line, kind of as the SSS approach, right? You have the underlying stressors here, could be physical stress, chemical stress, emotional stress, food allergies, bacterial overgrowth, sibo, right, all of these stressors, increase our stress bucket, and then the body systems start to dysfunction, hormones, digestion, immune detoxification, as the system starts to dysfunction, then you have all this, the symptoms happen down below. And so conventional medicine just band aids, these symptoms down below, they don’t ever go upstream. So you got to have conversations with your doctors that talk more about the upstream issues. And so we try to nullify all of the underlying stressors, make sure foods good chewings, good, hydrations. Good. And then we’re going to do tests that look at the function of the systems. So it’s a lot different of approach. So if you’re working with someone, you know, you want to be able to ask the right questions, what do you think the underlying root causes are, and as a patient, make sure you walk into it with an open mind that there’s probably not one underlying issue, it’s probably a bunch of things that are spread out, that are part of the underlying cause, from a stress standpoint, and the body system standpoint that are emanating the symptoms downstream?

Evan Brand: Yeah, well said Well said, that’s a great, great visualization, and you have permission to have 4 5 6 7 8 9 10 things going on.

Dr. Justin Marchegiani: That’s the key, that’s that that’s the missing assumption, you could have a lot of different things. And then as you walk through with the clinician, and you’re making changes, you need to not go into it as Oh, I made this diet change and the supplement, I don’t feel better yet. It’s okay. There’s always a plan B, a Plan C, a plan D, a plan E. And if the answers down here, and E and F and you, you quit and get discouraged that B and C, then you never get a chance to kind of go deeper. So just as patients are listening here, always make sure you have that ability to kind of just like, have a good attitude and keep on progressing down the line.

Evan Brand: Yeah, and you can’t blame them on me. This is the way that people have been conditioned over decades and decades of conventional medicine, but it still does frustrate me when someone will approach us whether it’s a friend or a family member or something and they’ll say, Hey, you know, I’ve got autoimmune. I’ve got sjogrens or I’ve got alopecia or I’ve got, you know, diabetes type two. What’s wrong with me? Like, why did this happen? Where did this come from? It’s like, Where do I even start? You stay up till 1am? You posted a picture the other day on your Facebook page? Have you eating an ice cream Sunday? Yeah, never get exercise. I know what you do. You sit all day, you don’t get outside and you’ve never had a tan in your life. So you’re afraid of the sun. If you do go outside, you lather yourself in sunscreen chemicals. You don’t eat organic, you’re super stressed. I mean, you know, so when people ask, well, what’s wrong? Why is this happening? It’s almost like, Oh, are you ready for this? Because I’m about to open up Pandora’s box here. And I’m going to tell you 20 things of what’s happening, I’m gonna tell you 30 things of why this has happened to you. So it’s just a reeducation really, of telling people look, it’s there’s not a one smoking gun, rarely to you and I find one smoking gun.

Dr. Justin Marchegiani: Yep, I 100% agree. It’s nice every now and then where you kind of get a home run and functional medicine, when you kind of make a couple of changes. And it’s like boom, and you blast it out of the park. It’s always a good luck little ego check. Because you know, you work with a lot of difficult patients over over time. And so it’s nice to get a couple of home runs every now and then. But if you work with a good clinician that has the right algorithm and kind of goes through the things goes to the options that give you the greatest chance of success out of the gates, and then work to the things that give you the less success at the end, then you have the greatest chance of success as a patient early on. And you set the foundation for greater healing over time. So I think that’s really the most important mindset is clinically go with the high percenter options.

Evan Brand: Yeah, and I’m not being a bully here. And I’m not making First of these people, I’m just saying, we really need to re education. You know, you you people eventually come out of the woodwork at at you when you and I do what we do and they’re not ready for the red pill. They’re not you know, they’ll ask what’s wrong me? Why do I have diabetes? Or why do I have this headache? It’s like, ah, are you ready? Are you ready? Because there’s there’s a lot to uncover. There’s a lot to unpack.

Dr. Justin Marchegiani: Yeah, I think most people once they’ve kind of gone through the conventional medicine model, and they’ve kind of said, Hey, all right, well, I just don’t want to be relying on laxatives or enemas my whole life. What’s next? Usually, once there’s, they kind of have this level of like, okay, these are the only options I have from conventional medicine. There’s a level of openness that occurs from that, where they’re like, Alright, what’s next? What’s next? I’d see functional medicine and nutrition is helping people all the time, what’s next outside of this because they just kind of have this yearning that there’s got to be something more. And I think that’s creates a level of openness and readiness to. 

Evan Brand: Good point. Good point. Yeah. I often say people have to hit rock bottom or they have to be miserable enough to listen, I mean, you and I’ve heard countless stories of husbands and wives that are stubborn and they want to eat the pizza while the other spouse has to eat the grass fed steak and sweet potato that grass fed steak sweet potato tastes better anyway. So I don’t know what they’re doing. But But anyway, they’ve got to have their own issue right? And then finally, once the other person once they get miserable enough, then finally they’re they’re willing and you don’t have to drag them into this whole thing as much.

Dr. Justin Marchegiani: No, I totally agree. Well, if you guys are listening, and you enjoy the podcast here, put your comments down below. Really appreciate the thumbs up and a share. We also reviews are great JustinHealth.com/iTunes, EvanBrand.com/iTunes. It’s great. If you feel free to head over to EvanBrand.com you can schedule an appointment with Evan anywhere in the world. Vice versa with myself Dr. J at JustinHealth.com. We’re here to help y’all. And I appreciate you guys listening and just feel free to share this content with some friends or family that can benefit. Again, we’re clinicians that have had 10s of thousands of patients experience kind of combined, and we want to provide actionable information with y’all so you can take action and get your health back in your hands. So we really appreciate you guys being listeners and attending. 

Evan Brand: Take great care yourself. We’ll be back next week. 

Dr. Justin Marchegiani: Thanks.


References:

https://www.evanbrand.com/

https://justinhealth.com/

Audio Podcast:

https://justinhealth.libsyn.com/the-root-causes-of-constipation-slow-motility-podcast-331

The Carnivore Diet: Eating ONLY Meat

By Dr. Justin Marchegiani

The Carnivore Diet has recently gained a lot of popularity. In essence, the diet is very simple: just eat meat. The concept of eating only meat can be hard to wrap your head around- it goes against everything we’ve been told: fresh fruits and vegetables are important for well-being, meat causes heart disease, without fresh produce you can get scurvy, etc. Today we’re going to review the Carnivore Diet and debate some of the most common misconceptions.

What is The Carnivore Diet?

It is a high protein, moderate fat, and virtually zero-carb diet. The diet consists predominantly of meat, although some people allow other animal products such as butter and eggs. No fruits, vegetables, or grains allowed. While a common result of this diet is weight loss, people primarily start eating carnivore to address autoimmune conditions.  

What to Eat?

At its core, the Carnivore Diet is a meat-only diet. However, like with all diets, there are some grey areas. It is up to each individual to decide what works best for them. Since a large portion of those who start this way of eating do so to overcome health challenges and autoimmune issues, many choose to stick to meat-only. However, others choose to include other animal products as well.

Listen to Dr. J’s podcast with Caitlin Weeks (Grass Fed Girl) sharing her experience on the Carnivore Diet!

Foods Accepted in the Carnivore Diet

The staple food of the carnivore diet is beef: ground beef, steaks, simple sausage. Those who follow this diet report feeling the best and having the best results with beef. Other foods allowed on this diet include:

  • Poultry (chicken, turkey, etc.)
  • Lamb
  • Pork, bacon
  • Fish
  • Organ meats
  • Lard, tallow
  • Eggs
  • Bone marrow
  • Salt
  • Butter
  • Bone broth
  • Water

The grey area includes animal products such as yogurt, milk and cheese; as well as teas and coffee. Whether or not to include these items is completely up to each individual!

Meal Plan for Carnivore Diet: 1 Day of Eating

Here’s an example day of meals for someone on the Carnivore Diet. Keep in mind, this is structured after the typical 3-meals a day template most Americans abide by. However, most people on the Carnivore diet find that they can go much longer between meals. Meat is full of fat and protein, which can keep you satiated much longer.

Breakfast: Three eggs cooked in butter with a few slices of bacon.

Lunch: Rib eye steak.

Dinner: Hamburger patties with cheese.

Notice the lack of snacks; one of the advantages of the carnivore diet is the fullness factor of the high-protein consumption. Some people skip breakfast, others choose to eat just 2 meals per day (ex: the first around 11 AM and the second around 5 PM).

Benefits of the Carnivore Diet

It’s important to note that this way of eating has not been heavily studied, so most evidence is anecdotal. Many people suffering from extreme autoimmune conditions have found solace in the Carnivore Diet. When nothing else could provide them relief, meat was their saving grace.

This diet is thought to heal due to the anti-inflammatory aspect of eating meat. In a sense, this is an extreme elimination diet which gets rid of any possible food sensitivities or triggers. The Carnivore Diet has reportedly cured autoimmune conditions, depression, binge eating, and chronic pain.

Click here to work with a functional medicine doctor to get to the root problem of your health concerns!

Will the Carnivore Diet Meal Plan Help With Weight Loss?

Those who have tried the Carnivore Diet to heal their chronic illnesses rarely even mention the weight loss, because for them, it seems insignificant compared to the feeling of being healed after years or decades of living in illness! But nonetheless, the Carnivore Diet has also been shown to dramatically help with weight loss and muscle toning.

There are many reasons why the Carnivore Diet is so effective for weight loss. Firstly, you’re eating mainly protein and fat, which provide satiety and it eliminates mindless eating.

Additionally, you’re more than likely to switch into ketosis on this diet. When you’re in ketosis, your body is burning fat for fuel, rather than carbohydrates. So your body will essentially use the extra fat you’re carrying on your body to give you energy!

Health Risks of the Carnivore Diet

There are several myths and common concerns regarding this diet:

“Too much meat can cause kidney problems.” This is more of a concern for people who have preexisting kidney conditions. If you are going into this with strained kidneys or kidney disease, then your filtration system is already impaired and higher amounts of protein may be an issue. But if your kidneys are healthy, then the protein should be just fine!

“Eating only meat causes scurvy.” A common misconception is that eating only meat can cause vitamin deficiencies. First of all, meat does contain small amounts of vitamin C. Secondly, in a carbohydrate diet, we only require 10 mg/day of vitamin C to prevent scurvy. What’s more— research shows when on an all-meat diet, we require even less vitamin C to stay healthy.  

“Won’t you get super constipated?” Those on the Carnivore Diet have reported that, although it may take a week or so for your body to adjust, this diet does wonders for their colon and bowel movement regulation!

“Isn’t meat bad for you?” Please read our article on red meat’s supposed link to cancer. Essentially, the study that went viral was sensationalized, and there were a lot of factors that were overlooked. It is my firm belief that grass-fed, organic, free-range meats are healthy for you, no matter what diet you’re on! Quality matters.

Troubleshooting

If you decide to try the Carnivore Diet, be sure to choose fatty cuts, and don’t be stingy with the salt! Follow your intuition- if you want to throw a slab of butter on top of your steak, or want to choose the fattiest meat cuts you can find- do so! Don’t start this diet primarily to lose weight, and then start counting calories. Your body requires fat and plenty of electrolytes to stay healthy. If you skimp on the salt, you will notice. Headaches will probably be your first clue! Additionally, be sure to drink plenty of high-quality water (filtered water, or spring water if it’s available!). You might even consider sprinkling some salt into your water to keep yourself hydrated.

Who is the Carnivore Diet For?   

As we’ve noted, people with chronic illnesses and autoimmune diseases are among the finest candidates for the Carnivore Diet. If you have been suffering from undetermined food intolerances, you might consider the carnivore diet as a short-term elimination diet to uncover your trigger foods.

Anyone with kidney disease or eating disorders should think twice before diving into the Carnivore Diet. We advise anyone considering this way of eating talk to a functional medicine practitioner to better advise on an individual-basis.

Is the Carnivore Diet right for you? Click here to ask a functional medicine doctor!

Resources:

  1. https://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(15)00444-1/fulltext
  2. https://www.ncbi.nlm.nih.gov/pubmed/28430644
  3. https://www.niddk.nih.gov/health-information/kidney-disease/chronic-kidney-disease-ckd/eating-nutrition/nutrition-advanced-chronic-kidney-disease-adults
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940663/
  5. https://www.sciencedaily.com/releases/2008/03/080320120726.htm?fbclid=IwAR2gz_ZiOPPNlOdBh_BwomSof-IMaJxEKVOC0lnDA-gD8Glm-VNOjndVyVA

Ketosis and Safe Natural Sweeteners | Podcast #210

If you’ve exceeded the pleasure that you’re getting out of pizza, cake, wine and everything else, diets may not just be suitable, as they are temporary.  In order to get that lasting change, you really need to engage in a lifestyle shift.

In today’s podcast, Dr. J. invites Thom King to share his experience and insights that led to his writing of the book “Guy Gone Keto”. Watch as they tackle about the effects of sugar to our body, safe and natural sweeteners, how meat have more nutrition than vegetables and all other good things. Sharing is caring!

Thom King

In this episode, we cover:

00:41    The Springboard of Discipline: Engaging in a Lifestyle Shift

08:23    Healthy Sweeteners

10:56    Effects of Sugar Intake Frequency to Insulin or Blood Sugar

16:57    Allulose, Stevia and Monk Fruit

21:17    Sugar Alcohols

23:04    Benefits of Ketogenic Diet on Thyroid

48:15    Metformin

33:46    Importance of Journaling

Youtube-icon

Dr. Justin Marchegiani: Hey there it’s Dr. Justin Marchegiani, welcome back to the podcast. We have Thom King here in the house. He is the author of the book, “Guy Gone Keto”. We’re gonna dive in to some ketosis topics today, we’re gonna talk about natural sweeteners that we can incorporate in. Uh- they aren’t gonna affect our blood sugars much, and we’re gonna just– what– whatever else may come about but, Thom, welcome to the podcast.

Thom King: Dr. J., such pleasure being on here. Thank you for having me and uh– this is truly an honor.

Dr. Justin Marchegiani: Well thank you so much. So, let’s just dive in a little bit and just talk about your book. What inspired you to write this book, “Guy Gone Keto” and– and what are the top 2 or 3 things that you’re hoping for the readers to– to pull out of it?

Thom King: Uhm– well the book was a– the book kind of draw organically so, I had, you know, I– I own a– a food manufacturing business and a– ingredients supply company. And we supply sweeteners to sports nutrition companies, I love those companies, uhm– actually supply and manufacture ketogenic-friendly foods. So, I was in Vegas for trade show and went out with uh– with a customer. And they bought dinner and I way overdid it as usual. Uhm– went back to my room with a– beautiful luxer, and– could not stand to look at myself in the mirror. I was 35 lbs. overweight, I– my blood pressure was like 190/99 and I– I felt like a tremendously huge fraud because I’m catering to the– to that particular industry and not following at all so, at that point, sort of the pai– the pain of my, I guess dishonesty, the pain of my, you know carrying extra weight and being sluggish, and not following any type of discipline, I’ve exceeded the pleasure that I was getting out eating the pizzas and the cake and the wine and everything else, so at that point, I’m like, “Look, I need to make a lifestyle change”, so I really started doing a lot of journaling. And I was doing data collection on my weight, my blood pressure, temperature, I mean, all of the data points that I could find. And– err– and also like, use it as a springboard for discipline, so after about a 6 to 8 months period, I basically had a book on my hand. So, I just took it to it to an editor and, we added a day and it’s really– it’s more about my journey–

Dr. Justin Marchegiani: Mm-hmm.

Thom King: –on making a lifestyle change than it is keto. And, so the take home, I would say for your listeners on this, uhm– the points that I wanted to– I– I guess bring up in the book are– it– you can’t actually have a diet like, diets are really temporary–

Dr. Justin Marchegiani: Mm-hmm.

Thom King: –solutions.

Dr. Justin Marchegiani: Mm-hmm.

Thom King: In order to get lasting change, you really need to engage in a– in a lifestyle shift.

Dr. Justin Marchegiani: Mm-hmm, mm-hmm.

Thom King: Uhm that’s one thing, and then the second thing is, why does it take to– to make a lifestyle shift and what are those– what are the components of the discipline uhm, you know, that’s required.

Dr. Justin Marchegiani: Very good points. Yeah, I mean, when I work with patients personally, we’re always talking about what’s the template, right? The template kind of gives us the flex– flexibility with our macronutrients, uh– some people may not need a– a keto template. I think most, tend to go better with a– you know a lower carb kind of paleo template so to speak. And typically, when your carbs get low enough your start spitting ketone as an alternative fuel source. And then, there you go, you have the keto diet is kind of off of that so we can adjust macronutrients in– in a bunch of different ways. But I think the commonality that needs to be present in all diet or lifestyle shift is where you need high amount of nu– nutritional density. Lot of nutrients per bite, we need an anti-inflammatory diet, right? Not with the junky omega-6 uhm– fats and the trans fats, and a high sugar stuff, and then we also need low-toxicity organic, you know, low hormones, all those good things. Any thoughts in that?

Thom King: Yeah, a lot– a lot is the definitely coming up for me. Uhm– and so, when you know, when you’re working with your patients, and– you know, you’re [clears throat]– when you say dense micronutrients, I mean, are you referring to– like more– like I would say, uh– like carbohydrates or vegetables, leafy greens, preciferous vegetables, you know, that– you know that have like those micronutrients, and then also you know, the– the fiber. Is that the– is that what you’re talking about in–

Dr. Justin Marchegiani: Yeah.

Thom King: –this nutrition?

Dr. Justin Marchegiani: Yeah, yeah. Absolutely, so, of course like, uhm– vegetables, bone broth, uh– organ meats are incredibly nutrient-dense. If we really look at a lot of the nutrient-density– you know scales that are– that are more out there today, they kind of favor a lot more of the vegetables. But when you’re really lo– and– and they also hinder. They have a negative impact for salts and saturated fat which isn’t really fair because that kind of negates the nutrients that are actually found in an animal products. But once you kind of control for the sodium and for the saturated fat, and you just look at the nutrient, you’d be surprised at how much nutrition’s in like, bacon, or high quality uhm– meat, especially organ meats. It’s pretty insane. Uhm– if you look at the amount of– let’s just say, uhm– nutrition that’s in like, 8 ounces of grass fed meat, you’d had to have 15 cups of kale to equal it. So yeah. So–

Thom King: Wow.

Dr. Justin Marchegiani: –we’re looking at the vegetables, we’re looking at the high quality uh– meats, and even organ meats to a possible, ’cause those are super nutrient-dense.

Thom King: Right. And so, you also mentioned like, anti-inflammatory, like properties of particular food? And, so, I found in uh– you know, in– in a ketogenic lifestyle, particularly uhm– you know, with me, it’s that I’ve been giving a lot of my– I guess fats– some of my fats, put a lot of my proteins from dairy. [Clears throat] you know, whey protein, KCN, and– and stuff like that. What– what are your thoughts on– on dairy and inflammation?

Dr. Justin Marchegiani: Well I think, whey proteins are one of these proteins that tends to be– it’s lowering KC in about 99% KC free and also 99% lactose-free. So most of the negative effects that you’re gonna see in dairy are gonna be in KC and they’re gonna be in lactose, right? You hear lactose intolerance, people can’t break it down. They get bloaty or gassy.

Thom King: Mm-hmm.

Dr. Justin Marchegiani: And then KC tends to be the more inflammatory component. So, when you do whey protein, you don’t like get that. Whey proteins are great– are great precursor to glutathione which is just like awesome master antioxidant because the amino acids are so– uhm sulfur-rich. And uhm– you know, I think there’s a lot of like, what’s tonight price talked about, you know, activator X, which is just Vitamin-K2, it’s commonly found in ghee or grass fed butter. So, I think if you’re doing like, those good he– healthy, higher quality dairy thing is better. I think some people tolerate, you know, the milk and the cheese, better is well, especially if it’s raw, unpasteurized, those kind of things. I don’t even do well with that, I get bloaty and gassy. So, I think it’s really individual but if you’re gonna do the dairy, it– you know, you wanna make sure it’s raw, unpasteurized. But I think the– the butter and the ghee tend to be awesome, really good.

Thom King: Interesting. And do you find– do you find that fermented dairy is easier to tolerate?

Dr. Justin Marchegiani: Well I think fermented dairy is gonna be better. But just because you want, you’re gonna have more B-Vitamins and– and more vitamin-K2 and such. I– it just tends to be have more enzymes. Those enzymes are gonna help with the processing of lactose, processing of the KCN. So just kinda like, predigest it a lot for you. So, they– and that’s kind of a benefit, but when I’m dealing with patients like, I’m cutting dairy out initially, but then that’s one of the first things we’ll have back in are gonna be like ghee and then butter. And ghee is just like a more clarified, filtered-out butter. It’s just les K– less KCN, less lactose.

Thom King: Interesting. And then so, don’t you need– you need Vitamin-K2 in order to– to be able to absorb Vitamin– uh– Vitamin-D3, right? Is that right?

Dr. Justin Marchegiani: Yeah but, connect the D3 and then A and then– uhm– Vitamin-K2 is really important. It kind of help escort the calcium into the bone. So, we wanna have healthy, strong bones as well. And then on that note I wanted to highlight uhm– ’cause you’re in– in the– in the sweetener industry, and I know that, you’re kind of like, you’re looking at things like stevia–

Thom King: Right.

Dr. Justin Marchegiani: And you– yeah monk fruit which are really interesting, and I’ve seen a lot of uhm– different videos where people are testing their blood sugar and I’ve seen it not actually go up, I’ve seen it actually drop a bit. What’s been your experience with kind of a healthier sweeteners that are out there?

Thom King: Well, so, I’m like huge on that a collection. And so, part of that data collection is I pull blood continually so–

Dr. Justin Marchegiani: Mm-hmm.

Thom King: I’m trying to see where my blood sugar levels are, I’m trying to see where my ketone levels are. So, and– and plus, since I provide ingredients, you know, to food manufacturers, I always make sure that I’m testing you know some of our sweetening systems and even the compounds we carry on myself. So, like I feel confident when I go in the lab but, you know, that what I’m– what’s going out to the consumer is, you know, is– uh– you know, is healthy or at least they’ve he– healthier options. So–

Dr. Justin Marchegiani: Right.

Thom King: –I’ve– what I’ve done is I’ve– I’ve pull blood sugar, you know, after consuming Aspartame and–

Dr. Justin Marchegiani: Mm-hmm.

Thom King: –I’ve pull blood sugar after consuming uh– Sucralose. Uhm– I blood– pull blood sugar levels with stevia and monk fruit. And I’ve found that stevia and monk fruit don’t affect my blood sugar levels whatsoever–

Dr. Justin Marchegiani: Yeah.

Thom King: However, like Aspartame and Sucralose does. And I’m not sure if it’s because of the uh– like dextrose or maltodextrin that they use to, you know–

Dr. Justin Marchegiani: Yes.

Thom King: –to– you know to– to cut it. Or uhm– another theory that I had and I think that this might not be too far off is that, your body– you know, your body recognizes things that are– exist in nature. And you have the ability to metabolize those particular things are recognizes it. And I think when you put something that’s been chemically manufactured like sucralose which is a– chlorinated sugar molecule, uhm– you know, or– or Aspartame which is a modified phenylalanine. You know–

Dr. Justin Marchegiani: Yes.

Thom King: –your body doesn’t recognize those. You know, it’s like, “Hey, this is super sweet, why do I do with this? I don’t know what it is”. So, you do get the– you do get the benefit of calorie abatement. Uhm– but the downside is that your body doesn’t really recognize it and you– it– what’s it say– uh– insulin response. Uh– what the– what are your thoughts on that?

Dr. Justin Marchegiani: Well, I think I’ve seen some of the same date. I’ve known some of the functional medicine docs that have done like, you know, they– on their YouTube page. They said, “Hey, you know, let’s– everyone, let’s a study and let’s test your blood sugar, you know, fasting 1 hour, 2 hours, 3 hours. Let’s compare regular meal then let’s add a little bit of stevia to your coffee or to whatever that drink is, mo– and then monk fruit”. And I’ve seen, you know, it’s not a scientific study, but you know, these studies cost millions of dollar to do–

Thom King: Right.

Dr. Justin Marchegiani: –in a formal setting, so I think this is– this is even better because it is instantaneous.

Thom King: Mm-hmm.

Dr. Justin Marchegiani: And I’ve seen people test their blood sugar and then they post their data really showing it didn’t go up, if not, dropped.

Thom King: Hmm…

Dr. Justin Marchegiani: And my– my big concern is I think it’s– I think it’s a viable alternative, and it’s something that I use sparingly.

Thom King: Mm-hmm.

Dr. Justin Marchegiani: The question is, is there like a dose-dependency where you frequently added so much, or maybe there starts to becoming a problem because you are telling your brain sweet. Now in punctuated periods, you know, 20% of the time, 10% of the time, it’s probably okay– do you find if it’s– if it’s frequent all the time that you’re starting to increase insulin or your blood sugar may go up over a longer period of time?

Thom King: Uhm I have not found that to be the case with myself. So–

Dr. Justin Marchegiani: Okay.

Thom King: I actually use bo– uh– we have a proprietary sweetener called KetoseSweet– uh KetoseSweet+. And it’s actually a blend of allulose, uhm– stevia and monk fruit.

Dr. Justin Marchegiani: Allulose is that new sugar alcohol I’m seeing? Couple places do. I wanna hear on that later on. I’ll– I’ll plant the seed now, we’ll– we’ll come back to that. That’s great.

Thom King: Perfect. That’s– that’s ___[12:00] sweeteners, so, you know, and I– wha– I’d noticed this over the past few years, you know when I really, you know, became a– committed to leading a ketogenic lifestyle, that my– uhm– my desire for sweets actually went down quite a bit, and foods that I would normally have eaten before, uh– you know, before I– I started keto, uhm– just don’t– they taste way too sweet to me. Like some of the bars that I used to eat, super sweet. So, I think that your palette shifts uhm– you know when you engage a– uh– a keto diet and you don’t–

Dr. Justin Marchegiani: Mm-hmm.

Thom King: –have the desire to– to have the– you know–

Dr. Justin Marchegiani: Mm-hmm.

Thom King: –have stevia or monk fruit. As far as like dosage levels go, uhm– I mean, we’ve got scientific papers that we use in conjunction with you know, with a formulation, and we– err– generally suggest that people stay under 5 to 10 grams of– of stevia or monk fruit, uhm on a daily basis. Uhm– and that is a lot– that’s a lot of stevia and a lot of monk fruit. But–

Dr. Justin Marchegiani: Totally.

Thom King: But– you know, at that point ’cause I’ve dosed myself to that level and I’ve dosed myself to a hundred grams of erythritol, I’ve dosed myself to a hundred grams of uh– uh– allulose and so, I mean, I’ve tested blood sugar levels and– you know, also, you know jotted down notes on– uh– you know, like GI effect, because if you have too many like alcohol sugars, it can definitely cause bloating cramping, diarrhea, uhm– which you know, nobody wants.

Dr. Justin Marchegiani: No, that totally make sense. And I’m just curious, so, I like to also see– I’ve seen that as wll with the blood sugars not going up. I really like to see what fasting insulin’s doing. Is insulin for– potentially compensating at any level at all? Is insulin rising even though blood sugar’s dropping? Maybe insulin’s rising to compensate for that? I just precarious, you have any data on that?

Thom King: I don’t have any data on that. I mean, I would certainly collect data on that. Is there– is there a way to test for– for T4 and T3 uhm– like a home kit or something like that without having to go in and pull blood?

Dr. Justin Marchegiani: With T4 and T3, yeah there’s a couple of lab CRT and already in Valley lab’s definitely have them. And insulin I think you— I think you probably just have to just get like a– a ___[14:21] to have that done.

Thom King: Yeah.

Dr. Justin Marchegiani: Go everything in there with– I be curious, but I– I do know that those are gonna be things that typically don’t increase the blood sugar as much. Now one thing I– I do notice though is that some people that may have a negative experience, and I’m seeing just a lot of maltodextrin and corn sugar–

Thom King: Hmm.

Dr. Justin Marchegiani: And some of these sweeteners. What’s the deal with that?

Thom King: Uhm it’s cheap. [Laughs] So, any time you–

Dr. Justin Marchegiani: Does that defeat the purpose though? I mean, people are– are consuming these products to avoid sugar and then you have sugar in it. Which is like, “What?”.

Thom King: Well, I mean, it– it’s that– I think that that’s typical and, you know, in food manufacturing.

Dr. Justin Marchegiani: Yeah.

Thom King: That– you know, [clears throat] there’s– it– it’s tough ’cause it’s the– you know, people are trying to keep an eye on their cost of good sold, right? They’re trying keep high margins and– and the food that they’re selling. And– and maltodextrin and dextrose are so cheap that it’s easy, you know, it’s easy to use that as a– as a uh– as a filler or a bulking agent. So, uhm– you know, when you– when you look at typically like a high-grade sucralose, it’s gonna be 700 times sweeter than sugar. So you can’t really put something 700 times sweeter than sugar into little pocket, uhm– because– it there be a minute such a small amount you wouldn’t be able to actually detect it. So, you do have to use in those particular situations bulking agents. And so for larger, you know– uh manufacturers that don’t have, you know a contingency of consumers, uhm– you know that lean into natural uhm– they’re not even gonna question, you know, maltodextrin. But–

Dr. Justin Marchegiani: Right.

Thom King: ___[16:02] getting to your– to the point of– yeah, it’s completely counter– counter productive and counterintuitive to add back sugar into something [laughs] you’re trying to cut the sugar out. Well, so, yeah, it’s ab– absolutely 100%.

Dr. Justin Marchegiani: It seems like on a liquid, you’re probably have more ability to– to manipulate that because it’s a liquid, right? You can use a glycerin or some kind of liquid carrier that– you know, you don’t need a certain– a– a bulking if you’re using liquid drops. So, I’m just curious, uhm– what’s the alternative if you are trying to– to get it in a powder. Which are company using what have they found to be better.

Thom King: Uhm– we use lots of different, you know, uh– uh different sweeteners and different sweetening systems depending on what uh– you know, depending on the– the functionality in the outcome that the customers looking for like–

Dr. Justin Marchegiani: Can’t we rate down the ingredients in your keto-sweet product?

Thom King: Sure. So, uh– we have a product called a KetoSweet+ and it is– it’s allulose, stevia and monk fruit. And we have it both in a powder form, and we have it also in a liquid.

Dr. Justin Marchegiani: Is there a bulking agent with though with that at all?

Thom King: That’s the allulose. So, we usually–

Dr. Justin Marchegiani: Oh.

Thom King: The allulose is the bulking agent ’cause allulose is only about 70% of sweetened sugar. So–

Dr. Justin Marchegiani: I see.

Thom King: — in order to get to parity with sugar, we add stevia and then we add monk fruit as well. And so what we found is that, the combination of stevia and monk fruit actually mask each other’s off notes. Uhm– which is–

Dr. Justin Marchegiani: Aaahh.

Thom King: –super interesting. And then, you know, adding those two high intensity sweeteners to allulose which is 70% is sweetened sugar brings it to parity. So, our liquid– our liquid– KetoSweet+, I’d say you can compare it to like DE-42 high fructose corn syrup, or like–

Dr. Justin Marchegiani: Yeah.

Thom King: –any of like kerol or syrup that you would like, you know at the store. Uhm– and then, the– the powders just– very-very similar to sugar. Uhm– it’s not a sugar alcohol, it’s actually considered– still considered a saccharide, uhm–

Dr. Justin Marchegiani: Okay.

Thom King: So, think fermentation. So basically–

Dr. Justin Marchegiani: Yes.

Thom King: Uh– allulose exist in nature in small amounts.

Dr. Justin Marchegiani: Yes.

Thom King: It’s been considered a rare sugar.

Dr. Justin Marchegiani: Mm-hmm.

Thom King: And so, basically, take a– uh– fructose molecule and you treat it with an enzyme. So think fermentation.

Dr. Justin Marchegiani: Yup.

Thom King: And then, metabolite after that is a rare sugar called allulose. So– in allulose, your– you know, your– your body recognize it, recognizes it because it exist in nature. But your– because it’s been– you know, because it’s been enzymatically treated, your body is unable to metabolize it. So, it just basically goes through urine and feces and doesn’t affect blood sugar levels or uh– ketones. And what I have found is it actually drops your blood sugar levels slightly. Uhm– and I think it’s because of the enzymes that are used to– to manufacture that. Uhm– the beauty of the allulose, is its functionality. So, it participates in mallard which is the interaction of proteins and sugar that causes uhm– or creates a ___[19:13]–

Dr. Justin Marchegiani: Mm-hmm.

Thom King: So you’re using it in the baking process when you are making cookies or a cake, you’re not gonna get something that’s like brick, you are actually gonna get something–

Dr. Justin Marchegiani: Right.

Thom King: –that’s you know, crispy on the outside, fluffy and moist, you know, in the middle. So, it has that functionality and, I mean, to me, this is gonna be most definitely a– a game changer.

Dr. Justin Marchegiani: So, this– this allulose– and I have a couple of dark chocolates too that I– I do consume that are very low sugar that have allulose as this kind of sugar substitute. So I am seeing that catch on. And allulose is not in the same family, it’s like a paleo like– like xylitol or erythritol–

Thom King: Yeah.

Dr. Justin Marchegiani: –this is a– a polysaccharide you’re saying?

Thom King: It is. So, it’s actually a– [crosstalk]

Dr. Justin Marchegiani: Yeah?

Thom King: It– well, it’s actually a monosaccharide.

Dr. Justin Marchegiani: Monosaccharide is in the sugar?

Thom King: Yeah, but it’s not– but it– yeah, it’s definitely not at all like– like an alcohol sugar like xylitol, or maltitol or any of those–

Dr. Justin Marchegiani: And you don’t get any bloating if you consume too much?

Thom King: Uhm– I’ve dosed myself to a hundred grams, which is like err– like, 4 times which you, you know, you should be taking in, probably even more than that. And what I noticed is that, I had– it created some gas but it didn’t create like cramping or laxation. Uhm, I think that whether was happening is a level of fermentation. So, there’s probably some, you know, some bacteria in my gut that’s metabolizing it and–

Dr. Justin Marchegiani: Yeah.

Thom King: –off-gassing, but it wasn’t anything serious. And a hundred grams of that is a lot, like you have to force yourself to get it at your body.

Dr. Justin Marchegiani: Yeah, that’s like 3 and a half ounces, that’s– that’s a decent depth for sure.

Thom King: It is. And so, at that point, I would say don’t exceed that. I would say if you’re going to use allulose or something like that, uhm– you know, not to exceed maybe 15 or 20 grams.

Dr. Justin Marchegiani: Okay. Let– it makes a lot of sense. Uhm– anything else you wanted to highlight regarding other sweeteners? Is this the only major sweetener you have, or do you have any others like, what’s your opinion on like the birch bark xylitol? Any other opinions on the sugar alcohols, anything else you carry similar to that?

Thom King: Yeah, we carry all of the sugar alcohols, we carry xylitol, we carry–

Dr. Justin Marchegiani: Mm-hmm.

Thom King: –uh erythritol, and I mean, right now, erythritol is probably our biggest seller like we have an erythritol stevia blend, and we are able to process it in a natural powder so it dissolves into solution better, uhm– you know, companies that manufacture bars that are sort of extruded process, are able to use that sweetener, you know, ’cause it– it does dissolve uh– easier, so, in my opinion, like– so I have worked quite a bit with paleo’s, uhm– paleo’s have a tendency to increase water activity in the lower intestine.

Dr. Justin Marchegiani: Yeah.

Thom King: Uhm– which is– which can lead to bloating, cramping, diarrhea, uhm– xylitol I find, I mean, when you start talking about the m– maltitols of the world.

Dr. Justin Marchegiani: Yes.

Thom King: Maltitols of the world, the laxation effect that those had is pretty extreme.

Dr. Justin Marchegiani: Right.

Thom King: And I would say away from those unless you have really doped up the tolerance to sugar alcohols. Uhm– xylitol is a little less, but still pretty intense. If you over consume xylitol, you’ll definitely get a laxation effect. And I would say that the least, the– the sugar alcohol that has the least amount of– of uhm– of GI impact is gonna be erythritol.

Dr. Justin Marchegiani: Okay.

Thom King: And I think I would still recommend that people stay under 15 grams of erythritol per day.

Dr. Justin Marchegiani: Mm-hmm. Yeah, I think the big issue with a lot of these a m– m– mo– most are gonna come from uh– GMO corn. So, you could potentially get that round up– or that– that– that glyphosate pesticide uhm– potential trace in there as well which is common with a lot of the corn processing.

Thom King: Right.

Dr. Justin Marchegiani: Like the birch park, tends to be a little bit more of uhm– let’s just say the unadulterated form.

Thom King: Right, yeah. And we– you know, we– we have very– every one of our raw ingredients that comes in, uh– third party tested. So, and I mean, if you guys are– like any of your audience are gonna do business with, you know, with a ingredient company, you should actually 100% demand third party testing and see evidence of a thrid party testing. And part of our third-party testing is to test for like a GMO protein indicator. So, we’re always looking at, you know, we don’t anything in-house that’s GMO at all.

Dr. Justin Marchegiani: Interesting. I’m just curious, what are you finding in the– I mean, I’m not saying you guys did this but what have you found in the past when you started testing these things, did you find any of the round-up residue, did you find any lead or metals or mycotoxins that kinda– can you give us some of the bad stuff you found, in the past?

Thom King: [Laughs] Those are awesome questions. Uhm– and that is why we started doing third party testing. So, uhm– you know, I would say 10 years ago, when we just started getting into third party testing, we would find crazy, like shovel handle, uh– glove, like all sorts of adulteration in the products that we are getting.

Dr. Justin Marchegiani: Hold on, I wanna make sure I heard that. So, like, meaning like, particulate of a shovel handle? Particulate?

Thom King: No, I mean a shovel handle.

Dr. Justin Marchegiani: Like an actual piece of it in there?

Thom King: Yeah. And–

Dr. Justin Marchegiani: So, okay– I think the whole handle, you mean?

Thom King: No, probably 68 inches of the shovel handle.

Dr. Justin Marchegiani: Oh, my gosh! How does that happen? Like it’s crazy.

Thom King: I have no idea, or in the glove, like we found the glove, and–

Dr. Justin Marchegiani: Okay, got it.

Thom King: –so, I mean, a lot of these things– you– I mean– we– we do visual testing, so every– you know, all the raw– and this is back in the day. And we– we you know, we would– obviously not use those particular ___[24:51] after that, but anything that we bring in now goes into QC’s cluster. And we– you know, and we send it out for third party testing which test for heavy metals. Uh– test for Coliform, you know, various like yeast–

Dr. Justin Marchegiani: Yeah, bacteria.

Thom King: Or– uh– pe– uh– petrochemicals, uh– GMO protein indicators. So– we– we tested all that way, and I would say that our current blenders that we have in place, we don’t generally run into issues with them, uhm– I like to also add that everything that comes in and goes out of here runs through a metal detector. Uhm– you know, so, we– you know, we’re able to– to pull anything out that maybe the smallest piece of uh– of metal that, you know, got into it.

Dr. Justin Marchegiani: Yeah.

Thom King: But, uhm– when we– so when we start vetting new ingredient suppliers, I mean it’s a pretty– it’s a pretty rigorous uh– uh– task for them, you know, they have to give us all of their documents, their organic search, we send it off for third party testing, uhm– we will bring in, you know we could just bring a load from them, and then all of that gets tested. So, uhm– I wish more companies did that, because we’ve had products coming through our warehouse once we send ’em to third party, boom, they’re out of our warehouse and it’s like, no, this isn’t what we ordered. So, everything has to fall within a spec. And I would– it was really highly encourage, your– your listeners, to– I mean, and I know that they’re probably are getting a lot of their supplements through you and you’ve already vetted those companies, well I would say, oh, my God, like, I would say that, we’re just sweeteners. So, this is like, not a big deal but when you start looking at companies that are selling supplements and they’ve got a lot of compounds going in there, it– absolutely everything should be third party tested because I know in the supplement industry, 75% of the supplements out there don’t even contain any active compounds.

Dr. Justin Marchegiani: I agree. And this is a problem and that we test all of our– raw ingredients independently and I found increases in lead and some of these–

Thom King: Oh yeah.

Dr. Justin Marchegiani: –raw material back, and that can happen, of course, you know, you just over time find out who the best ones are–

Thom King: Right.

Dr. Justin Marchegiani: –where the qualities at. And then so you are also testing for like, round-up and or GMO type of contamination as well?

Thom King: Yeah, and I mean, in petrochemicals and heavy metals. So we test–

Dr. Justin Marchegiani: Oh.

Thom King: –for cadmium and lead, and, I mean, we’ve had products come in specifically from China which is kind of interesting, uhm– you know, that are showing up super high in cadmium and lead.

Dr. Justin Marchegiani: Mm-hmm.

Thom King: So, we do– I do a ton of formulation for companies. So companies will send us their product then in order for us to push it through our queue– our-our RND, uhm– we’ve gotta have ___[27:35] and then we also get that third party tested. And I found that, there’s a lot of P-Protein, uhm that is out of China that is super high in lead. And–

Dr. Justin Marchegiani: Oh.

Thom King: –I think it’s just because of the amount of the petrochemicals that get better in the air and then settle out into the soils. So, uhm–

Dr. Justin Marchegiani: Yes.

Thom King: Yeah, so we test– we test for– yeah, we test for all of those things–

Dr. Justin Marchegiani: Totally

Thom King: Uhm– you know, and– occasionally we find something but– at the more rigorous our– our testing has become, the more we are able to weed up the suppliers that are unscrupulous.

Dr. Justin Marchegiani: Yeah, very good. Now we talked a little bit earlier about in some of the benefits of being ketogenic earlier on the thyroid. I wanna just kinda peg you back to that because you are asking me some questions in the pre-interview like, you know, who’s gonna benefit from the ketogenic diet on– on the thyroid side? And this is a question I get a lot because you have some data– uhm, people saying, “Well, I– my thyroid gets worse or weaker on a ketogenic template and some gets better”, and I think a lot of it has to do with how insulin-resistant, how numb someone’s cells are to insulin. So the more numb you are to insulin, your body has to compensate by making more insulin to overcome that numbness. And I think that’s the big issue and kind of the physiological imbalance that’s driving a lot of issues with people’s heath and thyroid, and finding healthier sweeteners like you mentioned, getting the carbs down can really dese– uh– really increase the sensitivity, meaning it lowers the insulin–

Thom King: Mm-hmm.

Dr. Justin Marchegiani: –and that allows thyroid conversion to happen better because insulin’s a big blocker of thyroid conversion if it’s too– too high. Just answer that question.

Thom King: Right, yeah. And I mean, I found that with my– with myself. So, I was carrying about 35 lbs of extra– uh– of extra weight. And I mean I was definitely insulin– uh– resistant. And so, I did show a depleted T4, uhm– you know, when I started, and then that T4 leveled out. Uhm– but I’m not sure like on a– real long-term basis, uhm– how the thyroid will be affected, I mean, I test– like I do a batch test and–

Dr. Justin Marchegiani: Yeah.

Thom King: –and like I do full blood panel batch test and then I also uhm– do stool sample once a month–

Dr. Justin Marchegiani: Yup.

Thom King: –to track my microbiome.

Dr. Justin Marchegiani: Okay.

Thom King: So, yeah, I’m like, really– so I’ve really found some interesting stuff in this data collection that I’ve– have done. But I found that the ketogenic diet really did help my insulin resistance so I became more– more sensitive but you know, another– I– I would have like a question I guess, have– have you do you have any experience with uh– berberine with your patients?

Dr. Justin Marchegiani: Yeah, I mean, I use berberine a couple different ways. Uhm– with some patients it’s typically used in my SIBO-clearing programs where we’ll try to knock down SIBO or bacterial overgrowth.

Thom King: Mm-hmm.

Dr. Justin Marchegiani: And this– a bunch of different berberines, Goldenseal, ___[30:29], Barberry, you know, those kind of things. Obviously, yeah, berberine HCL. Uhm– but berberine’s also a really good insulin-sensitizing compound. It can really help lower your blood sugar, and– and lower your insulin levels. So there’s some really good benefits there as well.

Thom King: Right, ’cause I added that as a supplement and I almost wonder if that was, you know, if that really helped me become more uh– you know, more sensili– sensitive to uh– to insulin. And another thing too, is I’d like to hear your thoughts on– on Metformin.

Dr. Justin Marchegiani: Yeah, I think uhm– berberine kind of works similar, in a similar way it helps us uh– on the insulin sensitizing side. Metformin ‘s gonna work more by decreasing like the glucose absorption in the gut, and then it also kind of shuts down gluconeogenesis in the liver. Uhm– part of that decrease in the glucose absorption though, it can also decrease the absorption of B-12. So, if you’re on Metformin or Glucophage, you really wanna be on some supplemental B-12 on top of it. Uhm– and then, you know Metaformin’s relatively natural like the extract from Metaformin comes from the French Lilac flower, so it’s–

Thom King: Mm-hmm.

Dr. Justin Marchegiani: –it’s kind of on the natural side, uhm– but I tend to like be more impartial for like the Berberines and the other more nutrient-based insulin-sensitizing compounds. But if people are on it, you know, you just gotta make sure the B-12’s dialed in there too.

Thom King: Interesting. And do you feel like getting a B– uh– B-12 supplement with it or just increasing the amount of like– of– of uh– like organ meat would– would suffice?

Dr. Justin Marchegiani: I would just be a– I just make sure you’re on at least a good Malt tea with some extra B-12 on top of a really good diet.

Thom King: Interesting.

Dr. Justin Marchegiani: A– a– and again you can monitor that with you functional medicine doc like, you know, I like methylmalonic acids are really good tests to look at to assess your B-12 levels. Whien methylmalonic acid goes high, that actually means lower B-12, right? Methylmalonic acid gets metabolized to succinic acid. And so you need B-12 to make this conversion happen. So if there’s not enough B-12, methylmalonic go– acid goes up, if you don’t have that B-12 that convert it. So, let’s ___[32:31] if people are gonna be on it, you wanna be careful because, you know, lo– low B-12 can cause, you know, alzheimer’s dementia-like symptoms.

Thom King: Interesting. And then so, do you find like with your patients, that– that taking– taking these vitamins and supplements orally and/or do you feel like there’s greater efficacy in IV’s?

Dr. Justin Marchegiani: Well the– I mean, I think IV’s are good, the problem is they’re impractical for people to do daily, that’s the only issue.

Thom King: Mm-hmm.

Dr. Justin Marchegiani: Just because uhm– you know, people got a work, they don’t have, you know, 30 or 40 minutes to get drip in there, and that can be more expensive but–

Thom King: Right.

Dr. Justin Marchegiani: –uh– Iv’s here, they I think can be really good but, ideally you want good food and supplements are those easier take–

Thom King: Defenitely.

Dr. Justin Marchegiani: And that’s the big benefit. If I see patients that do a lot of gut issues then we will go on the– s– the sublingual B-12 side, and that can really help too because it can kind of get more of the absorption via the oral mucosal kind of buccal tissue versus the gut, and that can help too.

Thom King: Wow, awesome. [Laughs]

Dr. Justin Marchegiani: And then I’m just curious–

Thom King: Yeah.

Dr. Justin Marchegiani: What other– like what other key things, you know, you wrote the book, Gu– uh– uh– “Guy Gone Keto”, and you also–

Thom King: Great.

Dr. Justin Marchegiani: –come up some of these great sweeteners. What other cool tools are out there that you found kinda as– in your transition to a healthier diet, and making a lot of these health thing you think really impacted you?

Thom King: I would have to save the th– the thing or modality that had the greatest impact or what I found was the– the– the– lent itself to the success that I had was probably journaling. So, you know, that is– w– you know– and being mindful. So, when– when I get up in the morning, one of the first things I do, grab a cup of coffee, sit down and I start to journal, and you know, I journal with real intentions of things I wanna manifest. Uhm– you know, I do some data collection like my weight and blood pressure. Uhm– so, I think journaling was really-really-really huge. And really taking time to do that first thing in the morning sets the– sets the stage for your day. And then within that, I incorporated what I called “My Arrow of Power”.

Dr. Justin Marchegiani: Yup.

Thom King: Uhm– journaling, run, cycling, you know, I do try, and then you know, every other day, I do yoga and then I finish out my workout with a meditation. Uhm– and I think that those real things can actually helped me the most.

Dr. Justin Marchegiani: That’s really good to hear, that’s excellent. That sounds like something like a little Tony Robins kind of morning progress. That’s what it sound like.

Thom King: [Laughs] I’m totally influenced by Tony Robins.

Dr. Justin Marchegiani: That’s cool. And then I’m just curious too, just kind of piggyback on a couple things, where do you guys source your Allitol from the mean like– not like what company but like, wh– what’s the raw ingredient it comes from?

Thom King: You mean the allulose?

Dr. Justin Marchegiani: Yeah, I’m sorry, Allulose. I said Allitol– Allulose. Great.

Thom King: I don’t know but that’s a weird interesting compound. That’s not like the– the mix of– [laughs] of– erythritol and allulose.

Dr. Justin Marchegiani: Exactly, exactly, totally.

Thom King: Uhm– so, we– so I’ve been working woth allulose for the past five years and part of it was so new, uhm that the supply chain really wasn’t there.

Dr. Justin Marchegiani: Yeah.

Thom King: And we weren’t really able to verify stuff, so we won’t add– we won’t add something as an ingredient unless we’re– unless we’re 100% confident that the supply chain is solid, and also reliable like everything is– that arrives is within spec. So, the– the allulose, you know, we’ve got 3 different suppliers, and all three of those suppliers uhm– are using non-GMO uhm– corn fructose uh– substrate to– to enzymatically create the allulose.

Dr. Justin Marchegiani: Got it. So it’s corn fructose but it’s GMO-free and– and ___[36:11].

Thom King: Great.

Dr. Justin Marchegiani: Are they able to separate the– the sugar from the protein component pretty well?

Thom King: I think so, I mean– ’cause when we third party test, we’re not showing any proteins. Uhm–

Dr. Justin Marchegiani: Oh good.

Thom King: So, I mean I– I– I don’t have any reason to believe that there’s any problems with the– the– with them separating it. I know that they use like what’s called resin– resin column uh- filtration. So it pulls out like any of the pure– the– the impurities of– so– yeah, I mean we’ve been working with it for a while, and we third party test it and we haven’t found any– you know, any proteins in it to indicate that there’s, the– you know, the genetically modified uh– corn was used in that process.

Dr. Justin Marchegiani: So someone was gluten-sensitive and one of the ___[36:55] out, you’d feel like it would be filtered enough, it wouldn’t be a problem for them?

Thom King: Uhm- well, we’re also uh– allergen free– uh– facility, so we always test for– we test for gu– uh– you know, gluten? Uhm– and absolutely the allulose is gluten-free.

Dr. Justin Marchegiani: Good. And if they were sensitive to corn, like the corn protein like the zein protein, you feel like it’d be– it’d be filtered enough for there wouldn’t be an allerenic reaction to it?

Thom King: Yeah, I do, well, ’cause we test for proteins and there’s no proteins– there’s no proteins left in there, so I would– I would feel confident thst, uhm– yeah, that, that people, they are sensitive to that but not, you know, be affected by it.

Dr. Justin Marchegiani: Very cool. Well, we’re gonna have to put some links down below where people can find the KetoSweet+ formula–

Thom King: Oh.

Dr. Justin Marchegiani: Anything else Thom you wanted to highlight for the listeners here?

Thom King: Uhm– no, not really. You– we were the– the questions you asked worked totally through, and I appreciate that.

Dr. Justin Marchegiani: I appreciate you comin’s on. Anything else you wanna leave to listeners with for just– how– how they can find more about you and more about your products too?

Thom King: Uhm– well if you want to get a copy of the book, and we also have uh– we released a line of ketogenic uh– condiments like ketchup, barbecue, sauce–

Dr. Justin Marchegiani: Oh, cool.

Thom King: And– teriyaki sauce. And so, if you just go to guygoneketo, you can find all of that.

Dr. Justin Marchegiani: Right.

Thom King: Uhm– you can reach me through that too. Uhmm– all of the social medias under this Thom King, T-H-O-M, K-I-N-G. Uhm– reach out to me if you ever got– if you ever have questions. If they want to buy the KetoSweet+, I think kwe– the KetosSweet+ is available on the guygoneketo site. It’s also available on steviva.com, that’s S-T-E-V-I-A “dot com” that’s we have all of our compounds on there available for retail. And if they wanna see what kind of madness we’re up to in the– in our lab, they can go to iconfoods.com and follow us on linkedIn and you can see some of the craziness that goes on in our lab, things we’re inventing.

Dr. Justin Marchegiani: Very cool. And is it possible the coke with the KetosSweet+?

Thom King: Oh, absolutely, yeah. So, it does– it does actually participate in maillard at lower temperature, meaning that uhm– like with sucrose or table sugar, you– you’d probably about a hundred and forty-five–

Dr. Justin Marchegiani: Mm-hmm.

Thom King: –to a hundred and fifty-five as when it starts to caramelized, and you’re gonna noticed that you’re gonna get that a little sooner with the uh–

Dr. Justin Marchegiani: Mm-hmm.

Thom King: –with allulose, probably in the 130 to 135 range.

Dr. Justin Marchegiani: Mm-hmm, mm-hmm.

Thom King: So, probably wanna bake it and cook at little lower temperature for a little– e– extended period of time.

Dr. Justin Marchegiani: Mm-hmm.

Thom King: But then, you know, other than that, yeah, you can– cook and bake just like you would for a sugar.

Dr. Justin Marchegiani: Awesome Thom, well, thanks for all the great information here today, appreciate it. And you have a phenomenal day.

Thom King: Thanks, you too Dr. J., thanks for having me on.

Dr. Justin Marchegiani: Thank you. Bye now.

Thom King: You’re welcome.


References:

www.guygoneketo.com

www.stevia.com

www.iconfoods.com

https://justinhealth.com/

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