How Parasite Can Weaken Your Immune System | Podcast #285

Here’s another episode of Beyond Wellness Podcast! Parasites tend to live in our bodies. These organisms can enter our body anytime depending on what we touch, what environment we are in and especially on what we eat. If this happens, it doesn’t only affect our digestion but also our immune system. Check out this podcast with Evan Brand to know more about how parasites can weaken our immune health. Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

03:11     Parasites in our Body

09:30     Water and Food Components, Pre-digestion

18:32     Parasites effects in Digestion

22:54     Gut Stabilization

27:25     Protocol vs. Personalized Care

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Dr. Justin Marchegiani: Hey guys, it’s Dr. Justin Marchegiani here, we are going to have a fabulous podcast in store for you. Evan and I are going to be chatting about parasites and your immune system. Everyone’s talking about having a stronger immune system today, or at least with all the COVID-19 issues, people are concerned about having a stronger immune system. And we’re going to talk about how gut function can impact your immune system, especially parasites. Hey, Evan, how are you doing today, man? 

Evan Brand: I’m doing wonderful. You know, I think this whole thing’s been a big wake up call for people that have been ignoring their health. I think it’s really brought health to the forefront of the conversation and maybe people that have been ignoring their health or abusing their health or just simply being educated or naive about health issues. I think now people are kind of waking up to crap. There’s actually a correlation between my health on a day to day basis and what happens in society. So if society has some sickness going around, I can be more susceptible. I could be weaker, I could be more violent. Trouble and people don’t like that people don’t want to feel vulnerable. And so one of the biggest things I think increases vulnerability is predisposing factors we’ve talked about this weeks ago with the blood pressure issues and the heart disease issues and some of the other the comorbidities that were popping up with the viral issue now, not to get too off subject, but I did notice yesterday, the CDC finally updated their statistics, because we talked about how every death was being marked as COVID until proven otherwise. And now that they’ve updated that the number of deaths in the US has been cut in half, it’s been about a 50% drop. Now we’re showing even less than seasonal flu deaths. We’re showing like 35,000. So just wanted to point that out that that was updated for on the CDC website over the weekend.

Dr. Justin Marchegiani: Yeah, that makes sense. I mean, I talked to Dr. Rawls last week, and we had a really good conversation and one of the key questions I asked him was like, Hey, Doc, there’s two diagnosis. For COVID-19 there’s UO 7.1 UO 7.2. And I’m pretty sure that UO 7.2 is a subjective diagnosis for COVID. And I just told him, I said, Do you recall a subjective diagnosis and an objective diagnostic code for the flu or other types of respiratory infections? And he couldn’t recall that, you know, he’s a medical doctor for 35 years. So the concern for me is you have one diagnostic code that’s objective, right? You do a PCR test or some kind of testing to evaluate it right. And then the other one is totally subjective. AKA you have any upper respiratory infections you pass away, or or you pass away have diabetes or Alzheimer’s or cancer, but you also have COVID. Right? SARS 2Cov. virus, well, it just doesn’t feel right that that would be added to the death list. So I think we have some of these confounding variables. And we just got to keep that out there and we got to look at it and compare it to precedents. How does precedents look in regards to previous flu seasons? Even all cause mortality? How does it look? So I think it’s always good to have context. Context builds comfort? 

Evan Brand: Definitely, definitely. But back on to today’s subject, how is it tied in? Well, parasites are something that I’m sure humans have dealt with for a very, very long time. And there’s some people that argue that we could coexist with these pathogens. But our argument based on looking at thousands of people via lab testing is that and just clinically looking at symptoms and their skin and their moods and their sleep. Our argument is that you really can’t coexist with these pathogenic organisms that create inflammation, they disrupt the gut barrier, they’ve reduced stomach acid, they cause malabsorption. They allow bacteria to thrive and Candida to thrive. Maybe when the food supply was not tainted in the soil had minerals and there weren’t chemicals in the food and the water in the air. Maybe you could get away with it. But in the modern world, we just have too much toxin in our bucket to be able to come exist with thee. So you got to find them and then fix them.

Dr. Justin Marchegiani: Yeah, I tell patients, there’s two ways parasites cause problems, right? Number one is you get exposed to a large bolus of a parasite, whether it’s giardhiam, and some drinking water or e histo, or some worms in some undercooked meats right in such a large amount and overwhelms your system, or you get exposed by smaller amounts, and due to stress, your gut barrier, your IGA levels are weakened, your immune system is weakened, your hydrochloric acid levels are lower, your enzyme levels are lower, and you’re going to have a hard time keeping the area clean, you’re going to have a hard time digesting your food you’re going to have a hard time providing a compounds in the environment that can make it hard for bad stuff to grow. So like when we ferment different fatty acids and we acidify the small intestine like with butyric acid, for instance, or a lot of these acids that get produced through fermentation. Through good healthy probiotics, right? Remember lactobacillus acidophilus, acidophilus, literally translates to acid loving, these acids make it hard for bad critters to grow. Right. And so when we have an environment that is not healthy, we automatically make it easier for critters to grow for parasites to grow. And a lot of the detrimental effects of the parasite that may come in is going to be threefold. Number one, it’s going to stress out your immune system, right, which then sucks energy away from you because takes a lot of energy to fight stuff. Number two, it’s gonna affect your motility and your digestion, right? Your body’s natural response when you get exposed to a pathogen is what usually to excrete it out. So diarrhea, and so that creates very, very poor absorption because you’re flushing things out faster. You don’t have the time to break down protein breakdown back, reabsorb your electrolytes. And then number three, is you’re going to create good gut permeability, right, aka leaky gut and that’s going to create more food allergy issues and even more immune stress because you have immune cells in your small intestine in your stomach, aka the golf and the malt, right gastric associated lymphoid tissue in the stomach, mucosal associated lymphoid tissue in the small intestine, but then when you have gut permeability issues, and you increase that zonulin protein that unzips, those tight junctions, and now undigested food particles and even bacteria like endotoxin or parasite toxins can get into the bloodstream and create more immune stress. And now you start seeing cognitive issues like brain fog, mood and anxiety and fatigue, which most people don’t get it because they’re like, wait a minute, I got a parasite. I should have diarrhea, bloating or constipation. I have digestive issues, but you can have cognitive and mental emotional energy issues alongside of that, and that’s that overall connection.

Evan Brand: Yeah, well said great points and not to mention gluten increases on Yulin, too, so you’re talking about just a pathogen. Increasing Zonulin and creating leaky gut. Well, even if you didn’t have infections, you could be eating gluten or some other food allergen that’s increasing. Zonulin, separating those tight junctions and then boom, now all of a sudden, you’ve actually opened the doors. So let’s say you started out with no pathogens, you just had a diet that wasn’t right. Now all of a sudden gut barriers open. If you do get exposed to pathogens, it’s going to be easier for them to set up shop. I just want to cover a couple quick myths or maybe misconceptions about parasites I think people need to hear number one is that parasites are rare. This is a myth. We’ve seen thousands and thousands of clients around the world. The US is where we’ve seen the most clients. And I tell you, one in three, depending on the week could be two and three people show positive for some sort of pathogen, including parasites and so if many people have told us the story, hey, Dr. J. Hey, Evan. I’ve been to the gastro doc. They told me it’s not possible to have parasites because I didn’t go to any third world countries. We laugh at because we’ve seen all sorts of pathogens, I had many different parasites and I have not been out of the United States. And so that that’s Myth number one. Myth number two, I would say would be that you have to have some sort of strong, anti parasitic drugs to to fix them. We’ve had many clients who’ve done right now with antibiotics. And we’ve had them do rounds of anti parasitic medications. And in some cases, they still, they still actually show up positive for these bugs, indicating there is some sort of antibacterial resistance, there’s antifungal resistance, there’s anti parasitic resistance. And so if you’ve beat the drum on drugs, drugs, drugs, you need to just kill harder, you might need to switch your game plan up those those are just a couple misconceptions that come to head there may be more

Dr. Justin Marchegiani: Very, very, very good points. And I think the key point is Yeah, if you are very healthy, it’s possible that you have enough hydrochloric acid and IGA in immune response to be able to knock it out. But it’s it’s possible that even with a A large amount of the parasite exposure, you’re going to fall prey. And let’s not forget, the number three cause of death and many third world countries is dysentery usually caused by an amoeba or a parasite. So it’s the number three cause of death. Now, obviously, if you’re in a third world country you have, you don’t have good plumbing situation. So you’re going to be just around a lot of people debris that you normally wouldn’t be. So of course, plumbing, indoor plumbing is one of the best things there and obviously clean water. And again, personally, the water can still potentially have parasites in it. If you’re just drinking conventional well water or city water, it’s still possible. So I recommend having a really good whole house filter, or at least a high quality reverse osmosis filter. I’m going to put some links for some of the products that I personally use and have used for years. Down below in the show notes. So we’ll put down kind of the reverse osmosis filter that I personally have as well as the whole house. That’ll give you some extra buffer on being exposed to these parasites via the water supply. 

Evan Brand: Okay, let me let me say this real quick Yeah, where you go off water, which is the fact that even if you are drinking tap water, let’s just say you’re lucky and maybe they use strong enough drugs or chemicals to kill off whatever parasite in the tap water, you’re still going to be getting exposed to small doses of antibiotics, you’re going to be getting exposed to chlorine and chloramines, which are basically like antibiotics as well. We know chlorine does a really, really bad number to the beneficial bacteria in the gut. So let’s just say hey, you didn’t get parasites, but you’re still going to get chlorine. And if you’re taking a shower and unfiltered water, you’re getting chlorine through the skin that could potentially, you know, damage the the skin microbiome, but then the gut as well. So it to me it’s a you have to you got to have filtered water everywhere.

Dr. Justin Marchegiani: Exactly, and you hit the chlorine component. And there are other kind of metabolites of chlorine called chloramines, which it really disrupts the good bacteria in the in the gut and then what is the good gut good gut bacteria produce A lot of different compounds, one, they produce nutrients. And two, they’re going to produce these beneficial acids that make it hard for bad bacteria to grow. So number two, so if we kind of go back if I rehash that again, so you’re going to be weaker because you don’t have the extra B vitamins, and vitamin K and good nutrients produced by your gut. And on the other side, you’re going to have less of these environmentally altering compounds, these different acids that make it hard for the bad guys to grow. So now you have a lot more of a breeding ground because you’re missing the internal endogenous nutrients. And then you’re making it more hospitable for the bad guys to grow. So kind of my tagline over the years has always been good back to your bad bacteria, eats nutrients and poops toxins, good bacteria, eats poop, or pizza eats a good bacteria, eats toxins and then poops nutrients, right. good bacteria makes it hard for the bad guys to grow and then it produces all of these good news. treats as a beneficial byproduct.

Evan Brand: Yeah, let me say one more thing about water and then and then we’ll move on, which is people may say, Well I’ve been filtering my water or I only drink from my fridge filter will a fridge filter doesn’t do much so don’t have false sense of hope there. You really want to have more advanced filtration. But let’s say hey, I’ve got the water on point I’ve got this or that system. Okay, great. But lakes, rivers, creeks, I mean, basically all surface water contains Giardia and other waterborne parasites like crypto. So let’s say you go down to the neighborhood waterhole. You know, like for me it was Barton Springs down when I lived in Austin, I’d go swimming there. I loved it. I it was great water. It smelled fresh, it looked fresh, it felt fresh, but it was still surface freshwater that was runoff and so from runoff and so that very well could have been where I picked up my parasites. Let’s say you go to a waterpark with your kids and it’s probably all heavily chlorinated, but that doesn’t necessarily mean everything is pure there and you could get it up your nose and then All of a sudden you swallow it and then boom, it starts the reproductive cycle. So all of the recreational activities associated with water. That’s a really easy place that people don’t think about.

Dr. Justin Marchegiani: Yeah. And then what I typically do is because I’m big fan of waterskiing out in Lake Austin, when I would go, I would hit my GI Claire 4 right afterwards. And I would do some higher dose probiotics as well, just to kind of, you know, if there was a tiny amount of something in there, we could at least flush it out and knock it out right away. But I’ve definitely had some bouts where like, after I was waterskiing, I’m like, okay, something’s off with my digestive system. My foods been really good. So I’ve kind of always been in that pre emptive mode, when I get exposed to water that could potentially be a problem.

Evan Brand: That’s a good strategy. It’s not like you’re saying you’re taking a dose of antibiotics after you do waterskiing. You know, you’re taking some sort of herbal or maybe some sort of binder to mop up any toxins or debris that you got to Christ to so these are safe, low hanging fruit that you’re implementing.

Dr. Justin Marchegiani: 100% so in the water component, it’s really important obviously the food component, especially like pork and fish, and things like that make sure it’s well cooked. Those are just kind of common sense things. Of course, the higher quality, the animals are right and you know better animal husbandry kind of practices, the better, you know, chance that you’re not going to have infections and things like that in there. I mean, there are guys like, I What’s his name? Vondre planets. He was the big raw guy where he eat raw meat, like just straight up raw fish raw beef. I’m not sure I’d ever go that far. Okay, just because I wouldn’t go all in on that. I think cooking is a good thing. It does. One kind of sanitize some of these things, but to it pre digest some of these foods and makes it more accessible for idi our digestive system. And man, if you’re going to ever do raw meat, you better make sure you have a lot of hydrochloric acid production happening or you’re at least taking some HCl and enzymes as an insurance policy.

Evan Brand: Yeah, that’s hard work. And I think there was a book on that cooking made us human something about that how you know the evolutionary biologist go into cooking and help Cooking activates certain nutrients that you can’t get from raw and therefore that helped increase the size of the human brain and things like that. So, I don’t know not to get off so no, but But no- 

Dr. Justin Marchegiani: That’s definitely real. Okay. Yeah, that’s real. And then I tell my patients is when they have a lot of gut issues, think of cooking is pre digestion, right cooking is pre digestion. Now, does that mean we want to create a lot of heterocyclic amines or a lot of poly aromatic hydrocarbons through burning? No, we don’t want to burn. But if we can cook that’s excellent any, any additional charring that may happen you just consume a whole bunch of good plant nutrients with it and the antioxidants in those plant nutrients will neutralize any of the oxidative stress from the cooking of those foods.

Evan Brand: Yeah, you’re absolutely correct with the cooking being a pre digestion because when I did have parasites, I was unable to do anything raw, even raw fruit. For example, if I would just do blueberries, for example, I would poop out blueberries that were undigested I was like, Well, what the heck is going on? And so if I hadn’t even quote pre digested in terms of a smoothie, I was fine. But salads and leafy greens, you know, they tore up my gut for a long time until I was able to address my parasite infections reduce that toxic load, increase acids and enzymes go through the five or six hour approach that we talked about bringing in probiotics, knock out the Candida overgrowth that happened as well bring in some beneficial yeast like saccharomyces a lot of those things were were critical for me to expand my diet. I guess the one point I want to make is that the diet is something so many people focus on, but it’s not the root cause in many cases, you could go to 20 different nutritionist, they’ll put you on 20 different diets, but if you don’t address the parasites, I don’t care how strict or how good you are about avoiding, quote, food allergens, you won’t get better if you don’t address the underlying issue.

Dr. Justin Marchegiani: Yeah. And you know, I kind of go back and forth on that because I’ve seen some people where the food’s really just stressed out their guts so much, where their immune system was so compromised. They got an infection from it, like I find a lot of people where we can knock out their infection but they don’t fix their doctor. I tend to find that they get reinfected. So I’m not saying that the food is 100%. But in some people would say larger percentage than others. Does that make sense? 

Evan Brand: True. Yeah, don’t get me wrong. It’s still important. But I’m just speaking to the people that are like, hey, if I just stick on this food elimination diet forever, all my problems will get better. But that’s not magically going to make a grd infection go away, for example.

Dr. Justin Marchegiani: Correct. I’ve noticed clinically that patients that continue to eat gluten for instance, and we try to knock out like an H. pylori infection, I tend to find more reinfection on follow up tests, or people that really make the diet change, it’s easier to knock out the infection. And I think a combination of that is number one, just less inflammation. And that less inflammation means your immune system can deal with the infection as well. And so when you’re killing it out, the immune system can kind of okay, hey, we knocked out enough of that infection. Let me kind of help out and take over here as well. But if we have some of those stressful foods and the immune system is kind of still in corner, so to speak a little bit weak, and then we’re relying fully on the herbs. So if we can kind of lean on, you know, the herbal strategies, as well as the diet and lifestyle strategies, it provides good synergy.

Evan Brand: Yeah, I would agree it makes perfect sense.

Dr. Justin Marchegiani: Excellent. So a couple things I want to highlight because we talked about parasites is helping to improve our immune response when we knock them out, or if we’re infection free, right, kind of my attitude is everyone has the right to be infection free and everyone has the right to have more than one infection going on. That’s very possible. The second concern is these parasites can affect digestion. And what nutrients are we talking about? Well, we’re talking about things like zinc and magnesium and selenium. These are very important minerals that need to get ionized. We need hydrochloric acid to ionize them so they can be soluble in our bloodstream and so we can absorb them and utilize them and transport them. We also know antibodies, right or immune cells. IGG, IGA IGA IGM, antibodies are made from protein. So we actually need protein to make our antibody. So if we have deficits or let’s just say bottlenecks in our ability to digest and break down and utilize and assimilate and absorb protein that’s going to be a problem. And then what about our fat soluble vitamins like vitamin A, we know is really important for the lung epithelium. I was worried about COVID-19 and lung health. Vitamin A is very important. What about vitamin D? Well, we get it from the sun, right? We also may take it supplementally and get some from our food. So we need good absorption there to take in our vitamin D. What about vitamin C that’s a little bit easier. It’s water soluble, but if we have poor absorption, it’s possible we can have some bottlenecks, especially if our micro v lie in our small intestine are inflamed. Our micro villi are a little vacuum cleaners that suck up nutrients. So if we have inflamed or a trophic v ly from infections or food allergens, that’s going to be a problem. And then what about like our sulfur based amino acids like cysteine, glutamine, glycine, these are the amino acids that make glutathione glutathione is one of our main Master antioxidants it helps with our detoxification pathways. Good at ions are really important redox nutrient and redox means it gives off electrons so when we have a lot of lung inflammation especially with COVID we need to make sure that we are giving off we have enough fluidify on to deal with and give off electrons to stabilize the free radicals oxidative stress, it’s happening from the infection. Does that all make sense? 

Evan Brand: It does. It sounds like a mess when you say it all like that. But it is a mess, meaning you could really get disrupted from a hormonal perspective also, you kind of tied into the zinc and some of that but zinc is really important for mental health to you know, zinc is something that helps to balance out that zinc copper ratio. A lot of people have mental issues, whether it’s schizophrenia, or OCD or ADHD or all sorts of stuff that can be tied into an imbalance zinc copper ratio. So you may think that your mood issue is completely just on its own and a psychiatrist would help but no, it could be totally related to the parasite infection. Then one other thing I wanted to say too is regarding the toxic load you mentioned not having enough of your sulfur based amino acids, these are the precursors to make Bluetooth ion, well then that happens. Now you start picking up more toxins. So if you get exposed to glyphosate or you get exposed to toxic mold and mycotoxins, now all of a sudden, you don’t have any sort of mechanism to get rid of those things. So now you’re even at a more disadvantage. And this is how people can, people that don’t address these issues can become more sick over time. It’s because now the original thing the parasite disrupted the mechanism to get rid of the toxin over here. So now you’ve got a toxin problem over here, and you’ve got a parasite problem over there. And we see how this thing can spin out of control. The good news is it’s all completely reversible.

Dr. Justin Marchegiani: 100% and it’s it’s scary how it can spin out of control. I see it happen quite frequently. I know you kind of just echoed some of the toxicity aspect, but we know a lot of metals and various toxins, whether it’s pesticides or mold toxins that They get removed from our system via the hepatic biliary system, right big words, you break it down a pedo, meaning liver, biliary, meaning kind of the bile ducts and gallbladder. And it dumps it out into the small intestine. So if we have poor digestion or the guts already inflamed, or we have gut permeability issues, it’s possible we could reabsorb some of these toxins and have them go back into our system. So that’s where having binders to kind of like bind it up so we can escort out better and then just having better better gut function to begin with. Because the better gut function we have one our immune system is less stressed to we’re going to have better inflammatory, natural anti inflammatory capacity, because if our adrenals are stressed because of our guts, then we’re going to have weakened cortisol levels, we’re not going to be able to deal with inflammation. And of course, the more inflamed our gut is, the more permeability there is and the more chance that we’re going to reabsorb these toxins and create more stress. That’s why I always tell patients, you know, the first way to Work on toxicity issues is get your gut stabilized because that sets the foundation. So when we push detoxification pathways more and we dump more toxins into the gut, we have, you know, the right things in place to escort out of the body without reabsorbing it.

Evan Brand: Yep, well said and not to mention to these pathogens, they mess up the glue Khurana dacian pathway, and that’s a good pathway that you can conjugate toxins and get them out of the body as well. So you mentioned it’s the hepatic biliary system, you’ve got the glucose sanitation pathway that’s messed up, you’ve got the reduced acids and enzymes, it’s messed up. So yeah-

Dr. Justin Marchegiani: Methylation probably too.

Evan Brand: I’m sure because you don’t have the nutrients to fuel it, right.

Dr. Justin Marchegiani: Yeah. And or you’re not absorbing it as well right because b 12 absorption starts in the stomach, right and you make intrinsic factor to bind to the stomach. So if you have an inflamed gut, you know, you may not have enough of that intrinsic factor and then you absorb it later on and the helium of the end of the small intestine So if any inflammation there, it could really affect the absorption of that. And that’s a key nutrient along with full later on methylation.

Evan Brand: Yeah, one other mechanism to just to help people wrap their heads around it is the amino acids. So now if all of a sudden you’re not digesting your dietary proteins, it may be tough to put on muscle mass, you’re putting in all this work in the gym, you’re not getting anywhere, maybe you’re actually gaining body fat, or you just can’t build muscle or you’ve actually lost muscle mass, I lost significant amount of weight without trying despite his eating bison steak all the time, I continue to lose weight. And then the mental health piece, which I already hit on with the zinc and all of that. So if you don’t have the amino acids, now you can’t make neurotransmitters. So then you become more anxious, more depressed, more fatigue, your motivation goes down. You can’t focus you hit on the brain fog earlier, just in the infection. But what about the infection induced malabsorption causing even more brain fog? So it’s no surprise that these issues can affect every aspect of your life and you move to your sleep to your sex drive to your hormones. That’s why it’s really important to figure out what are you Against. And so that’s where we come in with doing a good clinical history because we may uncover something like Justin always talks about a trip to Mexico and then boom, something happened, or was it you went swimming at the neighborhood pool or was it you took a round of antibiotics. So the history is important. But then of course we use and leverage the testing that is so far advanced above what the conventional gastro doctor using at this point, which is kind of sad. I hate that it’s us. Why does it have to be us? We kind of have to be on the bleeding edge here because it’s going to take a while for the conventional gastroenterology to catch up and I did all those conventional tests. So this is not the Poopoo it is just to say look, I did it. I did the barium scan you drink a terrible drink. You lay on this table, they flip you up the X ray you they found nothing and they prescribed an acid blocking drug and sent me home. They had no clue I had h pylori, which was reducing my acid What if I would have done that? I would have reduced my stomach acid even more I would have became even more sick. Luckily, I didn’t go that route.

Dr. Justin Marchegiani: Yeah, you would have more nutrient deficiencies more compromised immune system. And again, you know your gut maybe a little bit less inflamed the short the short term but every you’re not going to fixing the root cause and, and your nutrients that you need are going to be malabsorption. That makes a lot of sense. And I just kind of want to highlight people that are listening, you know, we’re talking about immune stress and we were trying to switch the narrative to boosting and supporting our immune system is evident Dr. J saying right now Hey, if you want to have a stronger immune system, especially against COVID should you go do a parasite cleanse right now? No, I’m we’re not saying that. But because if you are doing it indiscriminately, if you’re not working with the practitioner, you may cause more stress right now because you don’t have the foundations lined up ahead of time. So if you have immune stress, if you have gut stress, you need to be working with a practitioner, but at least work on some of the foundational supporting dietary strategies and nutrients to kind of get going. We already talked about some of these things, vitamin A, vitamin D, vitamin C, some kind of a paleo template as a starting point. Then work with a practitioner if you think there’s other gut stressors going on, because you may actually make your immune system weaker if you don’t have the right sequence in which you go after these infections, and that may be counterproductive if you’re listening to this podcast saying, I want to make myself stronger in my immune function, and I’m going to go after and do a whole bunch of parasite cleanse, you may actually have the opposite effect. And we don’t want you walking away with negative results.

Evan Brand: Yeah, it’s a bit of a stressor, right? I mean, it takes work. That’s why we talk about sometimes we’ve got to support somebody and sort of build up their foundation. Before we start picking the interior paint color of the house, you’ve got to get the foundation you got to get the walls you got to get the windows in because if you go straight to kill, kill, kill, you may feel worse, you may have die off and all that. Now you mentioned practitioner and of course we love helping people. So we want people to work with us so that we know the type of care they’re going to receive. We know they’re going to get the right testing. We know they’re going to get the right protocol to fix the issue. But let’s briefly talk about the DIY method because you and I I have so much stuff on our head, you and I both have courses that we’re working on. Yep. And we have so many people that say, Well, I followed such and such cleanse online. And it’s just like a one page PDF. It’s like 20 different supplements that XYZ person says to buy, and then they do it. And then the person comes to us saying, Yeah, I did XYZ cleanse, and here I am, and they’re no better. Maybe they’re worse. Maybe let’s just talk for you and I sake but for the general public to the Compare and contrast of trying to lump everything into a one page PDF document, take all these herbs, everybody on the planet can do this protocol versus more one on one personalized care.

Dr. Justin Marchegiani: Yeah, so 100% I mean, you’re gonna have people recommend a whole bunch of herbals, recommend a whole bunch of probiotics, maybe some digestive support, and you are not looked at as an individual. When we look at a patient, we’re going to make sure you’re ready for that next step. There’s gonna be a sequencing and how things are added in. We’re going to have to Some objective markers to also quantify how good or how bad your stress handling systems are, whether it’s we’re looking at certain nutrient levels, or we’re looking at hormone levels, or we’re looking at gut permeability or inflammation in the gut. So there’s a whole bunch of things that we’re looking at that are quite objective that help us gauge if you’re ready, and if you’re not ready, what we need to do to get you there. So it’s good to have these objective markers, when you just have a PDF sheet with a couple of herbs on there, and some probiotics, and you just say, Take these here, and then No offense, if things go sideways. What do you do?

Evan Brand: Yeah, and so it gets it gets tricky. It does. And so this is kind of a, you know, a little secret. It’s not really a secret because we’ve talked about it before. Justin’s working on a course I’m working on a course and we’re having this battle between how do you take the hands on hand holding clinical piece that can really steer people from going in the wrong direction? How do you put that into something like that? So that’s what we’re, we’re kind of in the middle of working on now. And You mentioned some of these, maybe some of the lab testing that we can look at. And that’s that’s kind of where we’re different is it’s not just, here’s a protocol, it’s going to be, hey, there’s actually this test on the side. If you want to do that along with the course, you can look at that, based on that interpretation you can get on that lab. Now, you know, if you’re ready, boom, then you can go into something that’s a little bit more broad spectrum and have more success.

Dr. Justin Marchegiani: Correct. And we’re doing a little bit more cutting edge testing regarding some of the PCR test which is a little bit more sensitive. Some of the baselines tool engine testing that’s run at some of the conventional labs can missed off. A lot of times it’s not even run but most of the time it’s not gonna miss stuff. Number two, we may even run some urinary tests to look at systemic yeast issues or bacterial issues or maybe even breath tests. I see many even just conventional gastro is they’re not even doing the breath stuff which a lot more of the cutting edge gastroenterologist like Dr. Pimentel at Cedar Sinai, they’re running breath tests but a lot of the conventional Doc’s aren’t they may run a scope. They may see there’s some inflammation and then not know what to do next. Maybe recommend some acid blockers or some steroids or some, some kind of a biologic salomina, Allah, whatever to kind of get the inflammation down. But then what’s the cause? Right? Where’s the root cause coming from? Is it a food issue? Is your gut permeability? Is there an infection are there multiple infections, so we really want to line things up in a way. And some of the conventional testing can be okay for end stage or more extreme stuff. But it’s tend to not be great when you’re in that in between phase. And even people that are sick, I’ve seen come back as pretty normal. And that can be very, very frustrating as well. 

Evan Brand: Well, I had a female client last week, that same thing happened before she came to me. She went to her conventional Doc, they referred her to a gastro, she brought up all the bloating and burping and burning and all of that. And of course, they don’t say anything besides here’s an acid blocker and let’s go get a scope done. Guess what the camera or the capsule or some piece of technology for the endoscope actually got stuck inside of her and left inside of her. And now she’s having all these complications from it. Well, she’s got to go back get, you know, put under anesthesia again, get cut open so they can cut out whatever piece of the equipment broke off inside of her. And we’ve already run the stool testing and figured out what’s going on. She had an H pylori infection and a couple of bacterial overgrowth, Sky High inflammation was through the roof. We’ve got her on some calming herbs and some general anti microbials. To start, she’s already 50% better. And yet, you know, she did this scope, which revealed nothing so wildly unfortunate how it can happen.

Dr. Justin Marchegiani: Absolutely. Well, I think today was a really good chat. And I you know, I appreciate the fact that, you know, we’re talking theoretically, but practically, right? This is theory in practice, right? So we’re actually applying all these things. It’s not just something that we kind of spit balled on on the dry erase board. It’s something that’s been used hundreds, if not thousands of times. So you know, just to kind of juxtapose us versus other Talking Heads online. Most of the things out there may be decent information, but maybe more theoretical, not practical. So the things that we’re doing, and we’re talking about are actually being used, right it’s all been set in Emotion we have a lot of hundreds of, if not thousands of clinical data points. So just kind of want to put that out there to kind of be a good value add for the patient’s listening, and also provide a little bit more confidence, people that are listening as well in regards to what we’re talking about.

Evan Brand: Yeah, that sounds good. Well, that sounds all good. But what does that actually mean? Well, that means that as soon as we press into recording today, we’re jumping right on the call with clients to implement the same stuff that we’re talking about. So that’s what it means. And we love what we do. So if you do need help, I’ve suffered tremendously. And I think through the suffering, it’s really, it’s really taught us both about number one, how to push through and number two, how to gain all the puzzle pieces you need, because there’s different stages of your journey where you may need this puzzle piece, pull that over here now implement that, and it’s a little tricky sometimes. So if you need help, please reach out. You can schedule a call with Dr. J at My website is, and we’ll be back again soon. So take good care.

Dr. Justin Marchegiani: Excellent. You guys have a phenomenal week. Take care. Bye.


Audio Podcast:

How To Boost your Immune System So You Don’t Get Sick – Dr. J Podcast #163

Dr. Justin Marchegiani and Evan Brand talk about immune health, which is such a relevant topic this flu season. Learn how sugar contributes to a weakened immune system and find out why vitamin D is important in supporting one’s immune system.

Discover some of the natural herbs and supplements to boost your immune system. And gain valuable information on topics like root canal, Raynaud’s phenomenon and glutathione in connection with your immune system.

In this episode, we cover:

02:13   Sugar and the Immune System

11:30   Glutathione IV

16:34   Supplements to boost Immune System

18:30   Raynaud’s Phenomenon

19:24   Root Canal



Dr. Justin Marchegiani: Dr. J is here. Evan, what’s going on, man? How was your weekend?

Evan Brand: Weekend was good as always. Hannah, my wife, showed me a picture. You are out there a waterskiing. She said like, “Is he freezing?” I said, “I don’t know. I have to ask him.”

Dr. Justin Marchegiani: Oh, man. It was phenomenal. I mean it was like maybe 65 minutes cold when you’re in colder water and you come up and the air hits it. But I had like a 3 to 4 mm uh— wetsuit and I am getting or I should say waterproof gloves and socks for next week. But I plan on waterskiing every weekend of the year that I’m here in Austin—So that is—January as well.

Evan Brand: That’s impressive. Who drives your boat?

Dr. Justin Marchegiani: Uh—I get one of my—my buddy here in Austin as well. He skis as well. So we both kinda just take turns.

Evan Brand: Uhh—

Dr. Justin Marchegiani: He’ll drive, I pull him and vice versa.

Evan Brand: That’s a lot of fun.

Dr. Justin Marchegiani: Yeah.

Evan Brand: Well, we’re proud of you for getting out there and practicing what you preach. Getting sunshine, getting movement, getting immersed in the elements of the earth and water and sunshine. That’s great.

Dr. Justin Marchegiani:  Totally. And also, you get the cold water thermogenesis going, which has some really good health benefits activating that good brown fat really up regulates metabolism, uh— lot of good HPA axis stimulation when you’re exposed to cold like that. So that’s pretty cool.

Evan Brand: Awesome. Awesome.

Dr. Justin Marchegiani:  Awesome.

Evan Brand: We’re gonna chat about uh— immune health, immune function. Know, this time of the year everybody starts coughing and getting sick. It makes you paranoid makes you want to wear a mask everywhere you go, uh— which I don’t do, but I want to stay healthy. I don’t want to get sick, so that’s a big topic that we can hit on. Oh, look! Look! Speaking of—Samuel just commented. He just got over the flu. So there we go.

Dr. Justin Marchegiani: Look at that. Exactly. Exactly. So, I got an article we’ll talk about here today. It’s called, “What to what to do when you get sick?” Part one and part two. So if you go to my page here, you can grab that link by putting the— you know, what to do when you get sick in the search bar. We’ll put links, too, below these in the podcast as well as the YouTube videos, so you can access any of the things any supplements or any products or any of the material. Uh— really easy access for you. So, we’ll make sure that’s put in the reference section down below.

Evan Brand: Alright. So, I think we should hit the food sensitivity immune piece. I feel like a lot of people, if we use the immune system bucket analogy, a lot of people have their bucket full already due to food sensitivity. So do you want to open up the conversation on it?

Dr. Justin Marchegiani: Yeah. One of the big things is glucose and vitamin C that they look very, very similar to the body. So when you take excess amounts of sugar, especially refined sugar and you increase your blood sugar, uh— that can actually have a effects on decreasing vitamin C absorption or decreasing vitamin C activation. So, vitamin C binds to receptor sites on the macrophage and helps with uhm— you know, the stress of dealing with infections or you’re—you’re basically little pacmen and women gobbling up crap inside your blood stream. And vitamin C’s important. And if you have a lot of sugar in there, that’s gonna impede vitamin C from doing its thing. And sugar also has effects in suppressing the immune system, where they looked at vitamin C absorption or vitamin C activation over time period and you can see that you have significant immune decrease when you’re consuming refined sugar especially excess amounts refined sugar. And don’t forget, refined carbohydrates or more starchier carbs can convert to sugar. So if you were more in the insulin resistance side, that can—even—too much starch can really throw you off, for sure.

Evan Brand: Yeah. Now, what about the testing aspect of immune health? I mean, you’ve got your conventional doctors where they’ll run things like your white blood cells, where we can see things that get affected. If someone’s have like a chronic of virus or something that’s affecting their immune system, we’ll see like the white blood cell count drop. Uh— what else could we see conventionally? Would— would like the DHS ERP? Would that be valuable as uh— immune markers? Is that just gonna be completely and another ball field due to due to its inflammation?

Dr. Justin Marchegiani:  So if we’re talking like an acute like winter flu kind of thing, you really don’t have time to do a lot of testing. I find that the faster you act on whatever is going on, the greater chance you have of reducing getting sick. So, of course, we have the diet and lifestyle components, right? We have get more sleep. Your immune system sucks up a ton of energy. So when you’re trying to kill a bacteria or virus, you really want to make sure your immune system has extra reserves. So get more sleep coz you’ll be more tired. Number two, decrease the refined sugar and excess carbohydrates from your diet, especially grains and refined sugar and alcohol, right? Uh— number three, I would say once we have the stress and the sleep and the diet on board which is kinda like everything, we would then move towards supplements. And of course, we have one our favorite things is medicinal mushrooms. So I am a big fan of Reishi or Cordyceps. You could even to Chaga as well. Doing these at 1 to 2 caps per hour too is a phenomenal way to boost up and up regulate your immune system.

Evan Brand: Yeah. I take mushrooms pretty much every day. I’ve been doing the uhh—an adrenal tincture. That’s Ashwaganda, Reishi, it’s got Chaga, Cordyceps. I basically take all of it together. I wanted to hit on the piece of vitamin D. Many people get their vitamin D check with their conventional docs and their levels are at 20 or 30 and that is just not high enough. And we had a question here from Prince about vitamin D from eggs and fish. “Is that enough or do we need to supplement?” Oh, no, he didn’t ask that. He said, “Do we need exposure to sunlight?” Yes, of course. If you can get exposure to sunlight, that’s great. But you know, there is such thing as a vitamin D winter. So if you’re at a northern latitude like in the Pittsburgh, you’re not get much vitamin D from the sun. So, maybe an hour a day. So, a lot of times it does take supplementation. Dr. Mercola, he prides himself on not having to supplement with vitamin D, but he lives on the beach in southern Florida. And he is out for three hours a day walking on the beach almost naked. So, he’s one exception, where he can omit supplementation. But for most of us, you know, that’s what it’s gonna take to get us into the optimal level. We know when we’re talking about flus and colds and all that, vitamin D is not at the optimal range. That can be a huge factor.

Dr. Justin Marchegiani: Oh, 100%. A hundred percent. So, off the bat, there is a couple things here. So we talked about vitamin D makes a big difference. Uh— one of the things we do is we’ll do vitamin D hundred thousand IUs which is a lot of vitamin D for three days. That really up regulates your immune system and up regulates these antimicrobial enzymes call cathelicidin. And they gobble up bacteria. So, high-dose vitamin D is one thing I do. We’ll do the medicinal mushrooms called Reishi. You know, Reishi or Cordyceps. I created—I formulated a blend called Immuno Supreme. And that’s a good blend of that has got Monolaurin in there. I have a Monolaurin Supreme as well you can use by itself. Monolaurin is nice because it can gobble up virus, digest the viral envelope. It’s kind of like uhm— viruses use the viral envelope, so the immune system can’t see them. It’s kinda like Harry Potter when he puts on the invisibility cloak. No one can see him, but when it’s off, you can see him. Well, same kind of thing with your immune system. Viruses have their own invisibility cloak. And the Monolaurin helps break it down. We’ll add in the Reishi or the medicinal mushrooms like the Reishi, the Cordyceps, or the Chaga, right? Those are super, super helpful. They get the immune system up regulated. I talked about the vitamin D hundred thousand IUs. I also make note of the vitamin C. We’ll get the vitamin C are pretty high as well, maybe 8000 mg 9000 mg which is equal to eight or 9 g daily. You know, just below bowel tolerance.

Evan Brand: So the Monoluarin, would you use that more like a spot treatment if something comes up? Or are you saying you may even do that throughout a winter season?

Dr. Justin Marchegiani: Great question. So, off the bat, let’s kinda like break things down into symptoms or let’s just kinda give you like a general scenario. So, this morning, I woke up, my throat’s a little bit dry. So, my wife had the heat on a little bit higher in the house. Sometimes the heat could do it. So I’m kinda like, I’m on high alert. So, of course, I am smashing my adaptogens, right? I’m hitting up a lot of Ahswaganda right now. And I’m gonna go crush some vitamin D a bit.  And I’m also gonna go juice some fresh ginger. I’m also drinking some apple cider vinegar drinks. I kinda do some apple vinegar shots throughout the day coz that really grabs a lot of the mucus off the back of my throat, which is helpful. I’m gonna go make some fresh ginger tea. Ginger shown to have positive effects at knocking down biofilms and it has effects at preventing viruses from heating or adhesing onto the various cell walls. So keeps the viruses from sticking, so to speak. And it really helps the immune system against viral activation and it helps the lymphatics. So, keeps things moving, better lymphatics is gonna help my macrophages, you know, the little Pac-Man or woman of your body, gobbling up crap, right? So that’s helpful. So doing those things— the Apple cider vinegar, uhmm— the ginger tea, uh— the vitamin D, and course, I start to slam the mushrooms, too, because the medicinal mushrooms get your immune system like up regulated. It’s like saying it’s like taking the army, right? Or the snipers and putting them on high alert. They’re all like perch above, they’re looking down, they’re looking for anything that comes out to move, right? So that’s kinda what I look as the medicinal mushrooms are doing. It’s really getting the immune system ready.

Evan Brand: Now, how about Monolaurin? How would you compare and contrast that?

Is that, do you cycle on? Do you cycle off? I mean, what’s your take?

Dr. Justin Marchegiani: That’s a great question. In Immuno Supreme, we put Monolaurin in there. So, there’s a little bit in there, but it’s not gonna be at like a therapeutic level, where if you were to take it by itself. So if you have a sneaking suspicion that there’s a virus going around, right? And you know there’s some kinda virus that’s in the area, your kids bring it home, you just know, right? It’s flu season. You’re thinking it’s a virus issue. Then number one: I’d be hitting ginger tea. Number two: I’d be using the Immuno Supreme, okay? Number three: you can add in— you can add in additional medicinal mushroom, okay? Number four: you can throw in some silver and number five: you can throw in some Monolaurin by itself. I’ll typically do between 2 to 5 things depending on what’s going on. So number one, if I’m under a lot of stress and I start getting sick, then I’m like, “Crap, I need to really hit it hard.” Coz I know my immune system’s more stress. If I’m more relaxed and there’s not a lot of stress going on and I’m sleeping really good, and I may just choose two or three things to start with. So and if I know people around me are coming down with the flu, then I’ll hit more things to help with the flu. Silver, medicinal mushrooms and of course, I’ll hit the Monolaurin by itself— couple of grams a day. 3-4 g a day.

Evan Brand: I like turkey tail. I wanna make some Turkey tail mushrooms. I have been using those a lot, too. And also, Astragalus. We love Astragalus, so I use it.

Dr. Justin Marchegiani: Astragalus is one of those herbs that kinda has an adaptogenic effect. And it cleanses the blood, too. And I will use that by itself. So I like five or six things in my medicine cabinet. I just stocked up last week ordering like three or four bottles of Reishi. Come the holiday season, I actually start adding in medicinal mushrooms that support my immune system at a low dose. I’ll do about  3 caps today. And if I start to feel anything, that goes from 3 to 12.

Evan Brand: Yup. That’s good. We got a question about glutathione IV for a healthy woman in her 40’s. “Is it worth it?” “And how often should I get it?” I’ll speak on it first and hear your take Justin. Uh— I’ve seen hundreds of times on the organic acids test and there’s actually some literature on this, that if you’re taking your precursors for glutathione, like you’re N-acetylcysteine or your vitamin C even in oral form, that you can actually boost up glutathione. So needing an IV if you say you’re a healthy woman, I just think it’s overkill. And it’s probably not necessary unless you just had some crisis thing going on and you needed a quick IV for it.

Dr. Justin Marchegiani: Great. Great point, Evan. So let me lay it out. There’s two scenarios, right? Scenario number one, is working with the functional medicine doctor as a long-term plan. From a long-term strategy, glutathione IVs are very expensive over a long-term. I mean, if you’re looking at like $30 $40 an IV, and you’re doing that couple times a week, long-term it’s not— it’s not a really good cost-effective solution. I much rather be using glutathione precursors and/or liposomal glutathione over a long-term kinda functional medicine program, okay. Number one if it used punctuated-wise because you’re in the middle of a—a heavy metal cleanse, or you have a lot of mold issues in your home and you’re using it as a punctuated circumstance, or you’re traveling, you decided to go to one of these natural clinics and get an IV coz your traveling and you’re under stress, that’s fine. Punctuated, short-term specific reasons it makes sense. Over a long-term, I don’t think it’s the most cost-effective because there— number one: you get stuck every day. Number two: it’s a little bit expensive. You’re better off using the precursors in the liposomal glutathione moreover the long-term. But I still see value in it and I kinda just outline those scenarios why.

Evan Brand: Yup. For sure. Uh—I’d say can we zoom out a bit. Let’s do like a 30,000 foot view of other things that could be affecting or suppressing someone’s immune system like dysbiosis in the gut, bacterial overgrowth, parasites, the candida issues, adrenal issues, heavy metal issues, liver detox problems. These are things that we see every single day in the clinic by running organic acids and stool testing. If you’ve got parasites or you’ve got chronic bacterial infections like H. pylori that’s suppressing your ability to make stomach acid, you’ve got the list undigested food because of the H. pylori that’s affecting your gut barrier creating leaky gut, therefore allowing the immune system to get under attack and create autoimmunity. So, I think from like a high point of view, outside of just the seasonal illness stuff this time of the year, if you haven’t approached and tested for your infections, your heavy metals, your detoxification markers, now’s a good time.

Dr. Justin Marchegiani: Yeah. I think it’s great. So, you know, looking where you’re at, I mean, most people that they’re not gonna stuck their medicine cabinet up with maybe five things, but I’d say let’s look at two things, right? So number one, I think the vitamin D is really important just because based on where the Earth’s latitude, the angle of that is at the this time of the year, it’s lower or its less direct, so you’re gonna have less UV exposure, so getting vitamin D is really hard. So getting the vitamin D up. And I went over the acute protocol for it. 100,000 IUs for three days. And step number two is some kind of immune booster. So, if you’re just a regular everyday person and you’re taking some adaptogens like I’ll just take more Ashwagana, which is great immune boosting benefits. Or if you want to add something in additionally, I recommend a vitamin—higher dose vitamin C, bioflavonoids and/or medicinal mushroom or if you want a multi-tasker, in my line Immuno Supreme is a good one. And I’ll put my link below and I know you have couple that you like in your line, Evan. We’ll make sure we put the link for those, too.

Evan Brand: Speak on the testing. Let’s talk about this. I mean, dysbiosis. If you got gut infections, you’ve got parasites, bacterial overgrowth like this is something in your bucket that you can take all the Reishi in the world, but if you’ve got infections, you’ve got infections—

Dr. Justin Marchegiani: Right. So again, there’s the zoom in and zoom out, right? So, over the long picture, over you know, over the— over the long run, big picture, we want to create a comprehensive functional medicine protocol that involves supporting the adrenals, fixing the gut, fixing the absorption, which then helps the detox, which then helps the immune system, right? So when that— in the long run, this is ideal, okay? But in the short run, people are like, “Hey, I want to be more natural. I want to be more holistic. I don’t want to— you know, get a vaccine or flu shot or you know beyond a synthetic NyQuil or whatever these drugs are that just control the symptoms. I wanna actually get healthier, but I don’t have time to jump into a functional medicine program. I’m starting to feel down now. What the hell do I do?” So the herbs that I mentioned they’re kinda like the quick fix in the short run. And of course, the easy things you can do in the short run, too, is cut all the sugar out, cut all the crap out, really increased nutrient density, more bone broth, ginger tea, right? Lots of good greens. Those kind of things. Lots of good healthy meats and fats. That’s you know— the diet stuff, the sugar stuff and then we talked about a couple supplement stuff. And in the long run, the goal will be to get you out of functional medicine plan, where we address all the other barriers that you mentioned that would enhance the immune system over the long run.

Evan Brand: For sure. I would give a couple other mentions, too. Uh— zinc can be helpful. You don’t have to go super high with zinc. You could do 15 mg of zinc –

Dr. Justin Marchegiani: Yup.

Evan Brand: Uh—and then there’s also some elderberry, which you don’t necessarily have to do long-term and then uh— Echinacea, too. You could bump some Echinacea up for a couple weeks and zinc, Echinacea, Elderberry. Uh—I’ve even seen your—your B pollens or your B propolis can be cool. Uh—sometimes, people are doing a little bit of the Manuka honeys, but sometimes it can be abused. So, I think those are couple good.

Dr. Justin Marchegiani: Yeah. We try to __a lot of great info about—you know, actionable info. And again, a lot of people are doing this. We’re putting it out there so everyone can kinda listen to what things, you know, really resonate. And I’ll put a link of some of these products that we—you know, I provide. Evan can do the same as well. So if you want some things that we formulated, we personally use, you can check what we have or you can go look at your local health food store and see what is near you as well. But that gives you a pretty good perspective there. Of course, big picture is we want to get, you know, fix the underlying issues. Short-term picture is here are some immune things that we can do to boost you up in the short run. So, today, I already hit the Reishi up and I’m gonna go hit some vitamin D up. I’ve already hit the Ashwaganda up and I’m gonna also hit my Immuno Supreme up as well. And I’ll do the Reishi again, three capsules around lunchtime and I’ll do three around dinner and before bed. So, I’m doing 12 a day right now just to make sure I’m up regulated. And also, I got my bedtime set tonight for 9:30- 10 o’clock. And I’m gonna get—I’m gonna sleep till probably eight, which is a little later than I normally do. So I’m gonna get a good 9-8, you know, 9-10 hrs. 10 hours, I’d say tonight to really make sure I recharge my body.

Evan Brand: That sleep is—I mean, sleep is free, too. So that’s always good and it actually has a huge effect. You could take all the supplements in the world, but if your sleep is terrible and you’re scrolling on Instagram till 2 AM, that’s bad. You’re not gonna be healthy. You’ve gotta—you’ve gotta address the lifestyle, too. You wanna answer a couple of questions here? We’ve— we’ve got one about – as we get deeper into winter the temperature, gets colder what you recommend for Raynaud’s phenomenon, cold hands, body’s—

Dr. Justin Marchegiani: You gotta fix the Raynaud’s phenomenon. That’s typically associated with autoimmunity, where it creates a vasospasm in the extremities and the vasculature spasm and then, you don’t get the blood flow there. So it gets colder and you can like, you know, make a motion on your finger and it just stays. It just stays there coz it’s not circulation. So, typically, there’s a thyroid component or an autoimmune component. I’ve seen these hundreds of times, where we actually get to the root cause and that tends to get better on its own.  So that is going to be— there is the symptomatic approach, which is get some better gloves with some heat warmers in there.  Root cause approach is functional medicine program that gets to the root cause: leaky gut, autoimmune, thyroid issues, for sure.

Evan Brand: Yup. Well said. A question about root canals. Person had a root canal removed, taking antibiotics. Suggestions on supplements to take after I’m done with antibiotics. I wish we could’ve prevented the root canal coz there’s a lot of issues with three canals. But you got it removed, so that’s good. Uh— suggestions on supplements to take after done with antibiotics. I mean what’s your take, Justin? There are so many—

Dr. Justin Marchegiani: Definitely good quality probiotics.  Ideally, we want to avoid root canals at all cost.  And again, if we get a root canal—Ideally, you want to have an extraction. You don’t want the tooth to be there because it’s basically like a diabetic who was a gangrenous limb and he just—you hollow out the bone and then there’s the skin flap there. It’s kinda like that, if you will. Coz what happens is the tissue is there. The tooth is there. But the immune system for that tooth is now gone. The circulatory and the immune system’s gone. So it’s where bacteria and viruses tend to hide. They go where the immune system isn’t, right? They’re pretty smart. They’re stealthy, right? They’ve been around millions of years and they have mechanisms to figure that out. So they’re gonna hide in that tooth cavity and you’re not gonna be able to touch it because the— now the bodies don’t have the capacity to reach the immune system that far, so—

Dr. Justin Marchegiani: Yeah. They’re scary. Dental stuff is huge. We should probably get a couple functional dentist on the show.

Dr. Justin Marchegiani: I’m gonna get in my end, Dr. Joan Sefcik in Austin, I’ll get her in and we’ll chat about – we’ve that we’ve got a lot of talks about it. But, in general, if you had its root canal and it still there, do some oil pulling to help act like a magnet the pony crud that could be there. Uh— I’ll look at tooth meridian chart and see where that tooth’s meridians on. What meridian, what organ system or neurological pathway it’s on and see if there any symptoms that you’re dealing with that time up in regards to the root canal and those organ systems and see if anything resonates there. And then number three: try to get ahead of it. Prevent it. If you’re listening and you haven’t gotten to try to prevent it. And number four: I would say potentially look for an extraction and then maybe a bridge option coz that way, you’ll at least have something in there that’s you know, bacteria and viruses are not gonna be able to live in like a sterile ceramic or sterile surgical steel type of implant.

Evan Brand: Yeah. But uh—for this person who had already taken the antibiotics, I would just say that you’d want to do—

Dr. Justin Marchegiani: Probiotics right now.

Evan Brand: You’d wanna do the probiotics. And I would say the leaky gut support, too. So you and I both have leaky gut formulas.

Dr. Justin Marchegiani: Uh-hmm.

Evan Brand: It could be helpful. So things that have the slippery elm and the marshmallow root. I’ve got one called the GI Soothe. What’s your—what’s your version called?

Dr. Justin Marchegiani: Yeah. GI Restore. Uhm—that’ll kill the viruses. Gargle it for 1 to 2 minutes and then swallow. In that way, it’s gonna be heading in that inner around that area, where the— the work was done. So if there’s any infection that’s held for sure.

Evan Brand: Yup. That’s good advice. Uh— supplement about HCl. Can you get an ulcer from HCl?

Dr. Justin Marchegiani: Yes, you can. If you have atrophic gastritis and your gut lining’s already really thin and you’re taking Hydrochloric Acid, it can definitely create irritation to the point—especially if you’re trying to work it up to tolerance. You’re trying to push it higher thinking that’s better. Then that could definitely create an issue there. So, of course, number one, if you’re feeling burning or irritation, don’t do that and back the dose often. Of course, take it with food. And then number two is adding some of the healing nutrients that Evan and I talked about. Whether it’s the the Gastro Soothe the G.I. Restore or something that has an L-glutamine kind of uh herbal anti-inflammatory support formula will really help with the gut lining.

Evan Brand: Yup.

Dr. Justin Marchegiani: Marshmallow, chamomile, all those things are great. A lot of L-glutamine of course, bone broth and ginger tea is also great, too.

Evan Brand: Cool. Awesome. We’re good. Well, I think we— I think we hit it all. Riley had a question about the vagal tone essential oil. Yeah, it’s helpful, Riley. It’s a good. It’s an essential oil formula and it works. So, it’s something else to have in your toolbox.

Dr. Justin Marchegiani: Yes. One of the herbs that are in there may be frankincense or lavender. Evan Brand: I have to pull—Let me pull it up—

Dr. Justin Marchegiani: A lot of these things what they’re really designed to do like a lot of the essential oils just help you relax a little better and the more your relaxed, meaning your—your nervous system kind of down regulates. There’s little bit less adrenaline flowing, your heartbeat’s a little slower. You can kind of relax, you start breathing a little bit deeper and it shifts your nervous system into a parasympathetic type of state, which is the rest and repair.

Evan Brand: Rest and repair. Yeah. What makes sense.—so this has got peppermint, Roman chamomile, nutmeg, so lemon balm and ginger.

Dr. Justin Marchegiani: Ginger is really great. You know, anti-inflammatory. Peppermint is great as well. Excellent for inflammation, too. Really helps relax you. Uhm— you mentioned chamomile’s really good for the gut, too. And then, what else? Yeah. I think there’s a lot of good things in there.

Evan Brand: Yeah. I sold quite a lot of it. So, I mean, it’s definitely a helpful—a helpful thing. I don’t think it’s a miracle cure, but it’s a good—

Dr. Justin Marchegiani: Is that a product that you provide?

Evan Brand: It’s a good thing to have. I do. Yeah. Ameo

Dr. Justin Marchegiani: So, you like it?

Evan Brand: Ameo is like—and I’ll send you—yeah. I like it. It’s good. I’ve got some at home. I use it. It’s cool. I’ll send you the link and—

Dr. Justin Marchegiani: Yeah. I have one or two. I have one by Doterra called Balance, which is good. There are some other ones I think on guard is a really good immune boosting one. You can take a couple of drops of On Guard and put it in some water and drink it. That’s really good immune booster. And also, too, if you’re traveling, you’re gonna be on an airplane, get your immune support boosted up because you’re just in a tube with a whole bunch of recycled air, right? And you know at least 10% of the people on that plane are probably actively sick and coughing and hacking, right? And that air just get totally recycled. So I’m always like, “Oop!” You know, I’m getting my immune support going, right? I’m predicting the worst when I get on an airplane. So my immune system is ready for the assault.

Evan Brand: Agreed. Agreed. And a couple questions—“Can you take immune supplements with food?”

Dr. Justin Marchegiani: Yup. Yup. Yeah.

Evan Brand: You sure can. “Do herbs contraindicated each other? Like oregano and Echinacea?” Anyone—

Dr. Justin Marchegiani: I don’t—I think you’re okay. Typically—

Evan Brand: Yeah. I was gonna say typically not. I mean there’s a couple cases where you know, you can’t mix medications with certain herbs, but even that, is—is not too big of a deal. Look up and you can type in your—your pharmaceuticals and you can actually compare that—

Dr. Justin Marchegiani: That’s cool. And also, you just got to be careful. The big contraindications tend to be ones that have effect blood thinning like ginger is a natural blood thinner. And like if you’re going in for surgery, there gonna want you to be off blood thinners. That would include like ginkgo or ginger or fish oil. So you just have to be very wary of it if you’re going in for surgery. You just have to look up and make sure a lot of the herbs that you’re doing aren’t having blood-thinning effects because you don’t want to be cut open and then bleed more. That’s not good.

Evan Brand: Yup. Yup. Cool. You wanna hit that question on brussel sprouts?

Dr. Justin Marchegiani: Yeah. Lots on the sulforaphane and the buzz about Rhonda Patrick for detox, immunity and general health. I think you’re referring to Rhonda Patrick. I think she’s on the Joe Rogan show just a little while back. Uhm— but, yeah, I mean, I think a lot of those cruciferous vegetables are great. There’s not a lot of refined sugar and such. So it’s not hurting your immune system. It’s a whole bunch of added nutrients for detoxification, which are great. Lot of antioxidant, which are great. Run those detox pathways better. I think there are a lot of good things a lot of good things about it. Again, I would need to know a little bit more about uh—detox immunity because it’s a lot of things that we use for detox and for immune health and gut health that we mentioned. And again, it’s not gonna all hinge upon broccoli or cruciferous vegetables. That’s maybe one small component. A lifestyle component, too. So, I wouldn’t hang my hat on all that.

Evan Brand: Uh-huh. Agreed. Yeah. I would say it’s helpful. I’ve done my own sprouts, too. I’ve actually purchased uh—some sprouting equipment. I’ve done it myself. I know Mercola talks about he does sunflower sprouts and stuff. So, yeah, is it a needle mover? I mean, maybe. It’s maybe 5% of the equation. Could it help? For sure. It’s not gonna hurt you. And it’s—you’re getting a lot more bang for your buck out of sprouts as opposed to—

Dr. Justin Marchegiani: Totally. And again, uhm— Charlotte asks, “Should you take biofilm disruptors and antimicrobial herbs at the same time?” In my supplement protocols, we always have ginger tea as an option that I—I push and suggest coz ginger is highly effective at disrupting biofilms. So, I’m a huge fan of adding in good quality ginger tea. And then, Riley uhm—said any supplements for sulfurophane or broccoli sprouts? Uh— typically, I would just look for a really good organic ground-up powder substitute. And then you just take a couple scoops of it and throw it in your shake. So I would look for a really good, organic substitute. I know we have one that we use that a special order called Paleo Greens. That’s one that we use. If you needed that as a special order, you could email the office and we could provide an invoice for you. But that’s one that we use. We look for organic. Uh—we want make sure we’re not throwing a whole bunch of concentrated pesticides and that you know, a wide array of green vegetables that we like, too.

Evan Brand: Yeah. There’s a patented version called__

Dr. Justin Marchegiani: That’s a different one.

Evan Brand: And it’s like 8% sulfurophane and there’s a couple different professional healthcare companies you’d have to get it through practitioner, but there some out there that are in extracted uh—broccoli sprout with I think it’s—let me tell you what it is—one capsule you get the equivalent of 500 g of fresh broccoli or 100 g of sprouts. So, I mean this put sprouts to shame, to be honest.

Dr. Justin Marchegiani: Yeah.

Evan Brand: Because of the concentration.

Dr. Justin Marchegiani: That’s great.

Evan Brand: Also to you too, excellent chat here.

Dr. Justin Marchegiani: Love it.

Evan Brand: I think that’s all the question. We’re probably good.

Dr. Justin Marchegiani: I just want the people to have the big picture is the big picture is get your immune system looked at and supported. 80% of your immune system lives in your gut. So making sure your digestion good, you’re infection free and you’re not adding in nutrients are not adding in toxins or excess sugar that’s gonna shut down your immune system. And then of course the sleep and then from there, that’s the big picture. Short term, we can always add in some of these natural herbal medicines that have been around for thousands of years to really get your immune system up regulated. And again, take a look at my article, “What to do when you get sick” part 1 and 2. There are some great options there.

Evan Brand: Yeah. Make sure you’re not too stressed, too. Make sure you’re not overworking. If you’re working 60 hours a week, I don’t care how many supplements you take. It’s not gonna—not gonna counteract it. You can’t out supplement your way out of a bad lifestyle. So, make sure that’s addressed and you know, if you’ve got bad people, get rid of them. If you got a bad job, try to change it. You know, there’s—

Dr. Justin Marchegiani: Totally. And one thing you can do, too, is get one of these apps. Like here’s one called, “Calm” Another one called “Headspace” Every couple of hours when you get stressed, do a 2 to 3 minute meditation, right? Maybe five if you have five.

Evan Brand: Yeah. It’s a piece of cake.

Dr. Justin Marchegiani: Like after this call, I’m gonna do a quick 5 minute meditation. And then I’ll get back into generating maybe other video after that and seeing patients in the afternoon. So the more stress— stressed you are kinda leverage now in the technology that’s out there to help get your parasympathetics more activated. Evan, great chatting with you.  Again, we talk about supplements. Take a look at some of the suggestions that we made in the reference section and also give you some ideas of your out uhm— abroad and you can kinda look at things that gives you good __ to choose from.

Evan Brand: If you’re listening on YouTube, make sure you hit subscribe on Justin’s channel. Subscribe. Subscribe. Subscribe.

Dr. Justin Marchegiani: YouTube is not giving people a lot of notifications. Hit the bell and then you’re– you have a higher likelihood you get notified.

Evan Brand: The algorithm—

Dr. Justin Marchegiani: Cross that bell and then you get all these little tip that say we drop them up. Evan, you take care.

Evan Brand: You take are.

Dr. Justin Marchegiani: Alright. Bye everyone.



Why You Keep Getting Sick, and What You Can Do about Those Flu Symptoms | Part 1

Why You Keep Getting Sick, and How to Boost Your Immune System | Part 2

Justin Health Immuno Supreme

Justin Health Monolaurin

Justin Health GI Restore

doTERRA Balance Essential Oil

doTERRA On Guard

Paleo Greens

Ameo Essential Oils


The entire contents of this website are based upon the opinions of Dr. Justin Marchegiani unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Justin and his community. Dr. Justin encourages you to make your own health care decisions based upon your research and in partnership with a qualified healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Dr. Marchegiani’s products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using any products.