Common Causes of Weight Loss Resistance

Weight Loss Resistance

By Dr. Justin Marchegiani

Weight loss is one of the common issues faced by many of us. Sometimes we think we have tried everything, but weight loss just never really happens. Watch this video and learn about reasons why we can’t seem to lose weight effectively. Gain valuable insight about the factors affecting weight loss resistance and determine if any of these factors apply to us.

Today’s talk will be on weight loss. Essentially, weight loss resistance. I see many patients here at the clinic have issues with weight loss. Some of the common things that I find that really are kinda the main cause of weight loss is because you didn’t try, you’re kind of on that calorie roller coaster. And every few years, you notice your rate keeps up and going up. And it kind of feel like it just may never stop.

Factors causing weight loss resistance:

  1. Inflammation
  2. Gut issues
  3. Toxins
  4. Over exercising

Factors Causing Weight Loss Resistance


Inflammation is a really common factor to chronic weight gain. What is inflammation? Inflammation, there’s a couple of different kinds.

Acute inflammation will be something like cut or sports injury. So cut for instance, you’re body’s going to form clotting factors that is going to produce a scab, and eventually that scab will let go. That’s great.

What we find in today’s society is we have chronic, systemic inflammation. The body is systemically inflamed due to diet and lifestyle factors. Man is causing essentially stimulating a hormone called cortisol. Other hormones, still we have cholecystokinin, but just to keep it simple for this generalization.

Cortisol, essentially, is driving belly fat bad, driving fat that is actually breaking down protein and muscle. And it’s interesting to know that a lot of receptors for cortisol are actually right around our bellies and hips.

So our real first goal is addressing weight gain, knocking down that cortisol. That’s one.  Where does cortisol come from? We’ll just kinda go over couple of a few factors you may find in my patients coming here.  

What causes inflammation?

Causes of Inflammation

Foods being the first thing that we see that can attribute to inflammation. When you have to do it every single meal,
and when you’re either putting food in your body that’s creating the anti-inflammatory state or you’re putting food in your body that’s creating the pro-inflammatory state, that’s one. So eating the right fatty acids is very helpful. People on this called low fat kick today, they’re not getting the right nutrients and I suppose that’s one factor.


So if you’re eating lots of peanuts and different foods, like grains for instance, then you’re increasing your mycotoxin exposure, it is going to have a huge effect when you gain fat.

Want to know more about the causes of inflammation? CLICK HERE


So as we eat these foods that will cause this inflammation around the gut. And essentially, we can see inflammation on the skin. But in the inside, we can’t really tell what’s going on.  So we’re eating foods that, in the inside, will cause the inflammation. It will cause inflammation, then couple of things happen.

We have our different microvilli in the inside of our intestines that are our little vacuum cleaners. It suck up nutrients. So one may suck up vitamin C, some calcium, some iron, etc. So if we get clogged our vacuum cleaners from inflammation, we can’t really take in a lot of the nutrients that we need. It’s important that these nutrients are using their radar energy systems. So it makes sense that we can’t get the nutrients that we need. Our energy system maybe a little bit low.


Toxins are another huge factor that we see. Your body is very intelligent. It knows toxins are dangerous to the organs, dangerous to the brain. Well it does its best job to sequester them. Sequester meaning it stores it in the fat and keeps it away from going to systemic circulation. So if our body is constantly expose to toxins, isn’t it a hard time letting go of fat? Because you notice that fat needs to be there to help buffer that bad toxin exposure. So if we do our best to decrease toxin exposure, mycotoxins, food allergens, etc., we  put our body into a huge step of healing and feeling better. And where we see that fat that maybe there’s a safety net, so to speak.


Now the common thing you see, super common is over exercising. Patients are doing exercises that are actually increasing cortisol. You can check the medical databases, that long distance cardio, especially marathon running, anything that I consider over 45 minutes to an hour, long-term is going to increase cortisol secretions.

Then again, we talk about cortisol, the receptors are on your tummy, they’re on the hips. So at the same time, you’re adding on hip fat and belly fat and you’re also burning up muscle.

So, we like to get people’s  exercise dialed in precisely.  And a lot of times, it’s not about getting working harder, it’s about working smarter. So short bursts, shorter range and high amplitude burst is going to be a much better solution.

Summary and Recommendation

Summary and RecommendationsNow, so overall, we looked at some exercise components. We looked at some food components, and toxins, toxic exposure components to how weight loss tends to accumulate. And over time, what we find is patients with a sluggish metabolism, overtime, tend to accumulate weight.  So really the key is to address the metabolism, fix it. It’s important that we do not want to lose some weight to get healthy. You get healthy and then you lose weight. So it’s kind of a different way of thinking.

So I hope this video helps everyone here. And any questions, feel free and let me know. We can always set up a consultation.

Are you having trouble losing weight? CLICK HERE to ask an expert about it. 


Detox 101: How to Enhance Your Body’s Detoxification

By Dr. Justin Marchegiani

Did you know your body is detoxifying all the time? It’s kind of a misnomer to say you are going to “detox” your system; it does this naturally. However, there are ways to up-regulate detoxification and enhance the body’s ability to excrete toxins from its main detoxifying systems.

Detoxification happens in body systems that include the skin, kidneys (urine), gut (stool), and breath. In Detox 101 we will cover phase 1 and phase 2 of detoxification.


What Is Detox?

During phase 1 and phase 2, fat-soluble (FS) toxins, such as Bisphenol A and various chemicals in the environment, are converted into water-soluble toxins. These toxins go through various biochemical processes, such as oxidation, reduction, and hydrolysis in phase 1 and sulfation, methylation, and acetylation in phase 2.

detoxification flow chart


Imagine putting a bunch of banana peels, orange rinds, or apple cores down the garbage disposal. You turn on the water, but now the sink is clogged. You run the garbage disposal to grind up the cellulose in the plant matter, liquefying it. Then you turn the water on again, and now all that debris, those “toxins,” are flushed down the drain.

Phase 1 of detoxification is like turning on the disposal to liquefy all that garbage. Phase 2 is like turning on the water to eliminate, or flush, all that debris down the drain.

If we don’t do a good job of liquefying these FS toxins in phase 1, and if we don’t do a good job of excreting them in phase 2, this can turn into a mess.

What would happen if the debris in the disposal hasn’t fully liquefied and we start running the water? The debris will clog the drain, making the mess much worse.

Phase 1 and phase 2 must work together for proper detoxification.

Toxins In Your Fat

Many people may gain stubborn weight that no matter what they do they just can’t lose it. Most toxins are fast soluble so the body has a propensity to shuttle toxins into these fat cells. The body will then be more resistant to burning up this toxin-filled fat until it has the capacity to do so.

In other words, if you have a detoxification system that is not operating at optimal function, excessive weight gain could be a side effect. Once the body’s phase 1 and phase 2 detoxification pathways are supported, the body finally has the ability to tap into these isolated fat cells!

I see this toxin-derived weight gain in my patients from time to time. Also lets not forgot that over 20% of thyroid hormone is activated in the liver. If the liver is under more stress, it makes sense that your thyroid function or thyroid hormones may not be at optimal levels to burn fat.

Your thyroid is one the master glands that controls metabolism. Metabolism is how your body creates energy…ideally from fat. The less metabolic energy you have, the harder it will be to tap into that stubborn fat.

food toxins and health

Detox, Protein, and Amino Acids

Protein is vital for detoxification to occur. Some of the main antioxidants that help with detoxification include glutathione and superoxide dismutase. Glutathione is a big one and is made up of three protein-based amino acids: cystine, glutamine, and glycine.

We need amino acids to run our detox pathways. Our body then eliminates these toxins, primarily via the stool and the urine. So it’s very important our gut function is working properly.

Check out the chart above to see all of the amino acids needed to run our detoxification system!

If you want to get your detoxification system checked, click here!

Detox and the Gut

The gallbladder is a small green organ just beneath the liver. After toxins enter the liver, the liver produces bile, and this bile concentrates in the gallbladder. The gallbladder spits bile into the intestinal tract, and the bile is eliminated from the body via the stool.

If the gut’s not working properly because we have dysbiosis or are chronically constipated, autointoxication, a process that slows down the activity in the small and large intestines, will occur. This creates more toxicity that will have to go through the whole detoxification process again.

This additional toxicity occurs because of the slowed activity and a bacteria in our gut called beta-glucoronidase. We conjugate bile, which means our body binds it into a toxin or a hormone so it can be eliminated. If the bacteria in our gut is out of balance, beta-glucoronidase can take those bound-up, or conjugated, toxins and uncleave, or unbind, them. So gut function is really important in detoxifying the body.

We don’t want dysbiosis. We want higher good bacteria and lower bad bacteria. Unfortunately, most people have higher bad bacteria and lower good bacteria.

Detox Testing

Detox testing can be done via blood tests or urinary tests.

Blood Tests

In conventional medicine we have our typical blood tests—CBC or CMP. Within these we look at the following specific tests:

  • ALT: Liver specific
  • AST: Heart and skeletal muscle specific
  • GGT: Gallbladder and bile duct specific

The ALT tends to be more focused to the liver, but it’s a more general marker.

The AST is also a liver marker, but there are various isoenzymes that can be broken down from this test. AST levels may increase during an acute episode of a heart attack or a hard CrossFit workout. However, if they are chronically high, it’s a good sign there are detoxification issues or liver problems.

The problem with the ALT and AST is chronic elevation in these blood tests doesn’t usually happen until late in the game. Full liver function is 100%; when it drops down to 10–20%, that’s when we’ll see the elevated tests. They are a late-stage indicator in the game of toxicity.

The GGT is a good marker for gallbladder issues, and it will elevate when something is going on in the gallbladder.

When the ALT, AST, or GGT goes above 20 or so, that’s when we will want to take a closer look and find what’s causing the elevation.

Urinary Organic Acid Test

Simple urinary tests can provide an assessment of organic acids in the body. The organic acids test includes the following:

  • 2 Methyl hippurate
  • Glucorate
  • Oratate
  • A-Hydroxybutyrate
  • Pyroglutamate
  • Sulfate

detox markers

These tests tend to be a little more significant because they are specific to different nutrients. If we’re looking at acetylation or sulfation, we look at the results of sulfer-based amino acids. Glucorate and 2 methyl hippurate can be more specific to B vitamins.

So organic acids give us really good indicators of what pathways aren’t working properly. Then we can put people on specific supplement programs to help up-regulate pathways that are low or out of balance. The organic acid test above is from my own personal test.


Anytime we are trying to detoxify, we want to stop putting toxins into our body. Eat organic foods, drink plenty of water, sleep well, and manage stress and blood sugar.

To eliminate or minimize stress on the body, make diet and lifestyle changes and address gut stressors and infections. It’s important to address infections because they will throw off the bacteria in the gut. If bacteria in the gut is off, it will create backup in the small and large intestines, which increases toxins and creates that vicious cycle. Diet should consist of the following:

  1. Foods high in sulfur amino acids, like cruciferous vegetables
  2. Organic grass-fed meat (
  3. Grass-fed whey protein concentrate

Looking at blood can be helpful, but it’s not the best functional indicator. Organic acids testing tends to be the best indicator when looking at the functions of detoxification, and then appropriate actions can be taken based on the results.

If you feel you are having a detox issue, reach out and schedule a consult to learn about your options. If you need more detox help, click here!

The entire contents of this website are based upon the opinions of Dr. Justin Marchegiani unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Justin and his community. Dr. Justin encourages you to make your own health care decisions based upon your research and in partnership with a qualified healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Dr. Marchegiani’s products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using any products.