Top 5 Ongoing Immune Supports | Podcast #341

Your first line of defense is to select a healthy lifestyle. Following general good-health guidelines is the best step you can take toward naturally keeping your immune system working correctly. Every part of the body, plus the immune system, functions better when protected from environmental strikes and bolstered by healthy-living strategies such as taking vitamins and some natural herbs that are evidence-based and fit you.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

0:35   Benefits of Glutathione and NAC

7:31    Vitamin D Levels

9:14    Zinc and Quercetin

11:11   Vitamin C as an antioxidant

13:38  Herbal Compounds

15:41  Medicinal Mushrooms and Herbs;

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Dr. Justin Marchegiani: Hey, guys! It’s Dr. Dr. Justin Marchegiani here today. I’m with Evan Brand and we’re going to talk about the top five ongoing immune supports. These are nutrient and or herbal compounds that we use to our patients to support a good, healthy, strong immune system. It’s obviously a couple of different areas and avenues we may use these preventively and as well as acute onset issues. So we’ll kind of talk about our experience clinically and how we use these in our practice. Excited. Evan, how are you doing today, man?

Evan Brand: Awesome! Doing really great and ready to dive in. So it’s going to start out with maybe that most important nutrient of all time, and certainly the most important nutrient for the past one to two years which is glutathione. And you and I did a podcast early on, I think it was last spring, all about glutathione and how we use oral acetylated glutathione. We’ll use liposomal glutathione, we’ll even used nebulized glutathione, and it’s been an absolute game changer  for so many people. I would even go as far as to say I’ve saved lives using glutathione. I will just leave it at that but, it’s an amazing compound, probably the most important compound, and our our mentor, awesome guy, Dr. Kalish. He did a great talk very recently about glutathione, and he was showing how important glutathione is with the body, and the body will prioritize production even over methylation and how important it is to really get this system working properly, and everyone is focused so much on methylation and they’re ignoring glutathione production. Everyone gets so caught up in mthfr, and genetic defects, and all that but they’re totally missing the boat on glutathione and this is your master antioxidant that is depleted during times of stress and during toxin exposure. So that could be any type of pathogen that could be mycotoxin we know that moltoxin will deplete glutathione, and you and I measure this routinely on urine testing, and I see low glutathione all the time. If we see organic acids that are too low or too high, we know that there’s a dysfunction going on, and this is something that can easily be remedied and supplemented and we have very very high quality sources that we use for people.

Dr. Justin Marchegiani: 100%. So glutathione is a tripeptide, right? So when we use glutathione, we’re going to kind of put glutathione and NAC in a similar camp. It’s good to have both, NAC helps with your, helps your body with endogenous production. Meaning, helps your body make it, as cystine tends to be the rate limiting amino acid in making glutathione. So glutathione is a tripeptide. So it’s got cysteine, glutamine, glycine. Glycine is really great in collagen and bone broth. Um, glutamine you’re going to just see in a lot of gut healing formulas because glutamine is needed for healthy gut function. So if you have healthy guts, or you have an unhealthy gut and inflamed gut, you can see how glutathione, one absorption, and um, of course stress is going to deplete a lot of those amino acids just in the stress process. And so then uh, you make glutathione via those three amino acids and then also you have exogenous glutathione that’s giving someone’s acetyl glutathione or liposomal, or some kind of a reduced glutathione which are all great. Um, those are all going to be exogenously you know, from the outside in. Endogenous is making it inside with the amino acid. So it’s good to help with both. We know the data on glutathione, it helps with inflammation, it has and effect on modulating the immune system, modulating the or t regulatory cells and balancing that th1, th2 immune response . Th2 is going to be the antibody response the, the th1 response is going to be the natural killers of the special forces of our immune system, and then of course, glutathione helps produce compounds like um, catabolic enzymes like catalase and a lot of good natural disinfectants like superoxidise mutase and things that help with lung, and inflammatory health inside the lungs. You’re going to make a lot of these compounds with glutathione which are very powerful on the immune side. Excuse me, I need some glutathione now. On the immune side and also on the anti-inflammatory side. So like for instance, with a lot of lung health issues or breathing issues, we may even give reduced gluathione and a nebulizer because, that is shown according to research, to help with inflammation, and help with vasodilation in the lungs. So very powerful anti-inflammatory, very powerful disinfectant because of the superoxide dismutase, and that catalase enzymes which is really important for inflammation.

Evan Brand: Yeah, well said. I mean every hospital, especially every ICU, especially when it with luncg issues, I mean, every ICU should be passing out glutathione nebulizers. It’s amazing that that’s not standard practice, that’s not standard procedure. We would see much, much, much healthier people faster recovery times if that were part of the protocol.

Dr. Justin Marchegiani: Yeah. That’s a patient with some serious lung issues who we nebulized some reduced glutathione and within a day, we saw a massive massive improvement. And we know things like NAC for instance is shown to reduce virus replication. So that’s very powerful. So when you’re, when a virus kind of gets into your cells, it replicates and that’s how it create symptoms. The viral load has to replicate and if you have nutrients in there like NAC , android glutathione that’s going to prevent the virus from replicating the higher number. So very very important there and of course, the higher the viral load is, the more you can spread it. If you keep the viral load down, the less chance of spreading and infection so that’s powerful there. Anything…

Evan Brand: An you and I take that ongoing. Yeah, you and I take that ongoing. We do depending on what’s going on. We’re not telling you to do this dose but, what you and I are doing, at least I know for me, I’ve got a combo product. So we’re using glutathione, give or take a couple of milligrams per day of an s-acetylated glutathione which in studies is just as good if not better than liposomal because with liposomal, we have some really sensitive people, me included. I don’t really do well with ethanol, and a lotof the alcohol that is in some of these liposomal formulas so I personally stay away from those. I like the acetylated, I fell great. It works really really well. Papers prove how well it works and then about a gram of give and take of NAC. So that’s kind of my on going protocol. And also for toxin exposure, that also helps protect against the oxidative stress that also helps to deal with mold tox and we know glutathione can help mobilize toxins. So that’s something we use in detox protocol too. Not just for immune and viral support .

Dr. Justin Marchegiani: 100% and virus replication, prevention, prevention, acute respiratory issues, all wonderful applications. I do about two grams a day of glutathione of and acetylcysteine, and one to two hundred milligrams of a glutathione whether it’s reduced as acetyl or liposomal. I’ll kind of rotate between the two. So that’s powerful out of the gates.

Evan Brand: Last call. Let me make one comment on the NAC and then we’ll move on. So at the time of this recording, uh, amazon has taken all NAC off of its marketplace. And there’s a lot of reasons that I could get into and probably  and get deleted for but, we’ll just say that NAC is gone but, you and I, we work with professional healthcare companies. We do still have availability so we will put link in the show notes because this is something I would recommend you have on hand, and if amazon’s going to take it away, at least we have it. So I think that’s important to know.

Dr. Justin Marchegiani: I think so too. I like it, NAC. In my product detox aminos, we have reduced glutathione plus NAC in there as well. I know you have a product similar as well. We’ll put links below so you guys can see that. And we’re gonna kind of a lot of the compounds like five herbals slash immune compounds and then we’ll kind of look at the nutrients. And I always tell patients like focus on the nutrients first just because they’re nutrients. They have other roles in the body and it’s good there. So NAC and I think glutathione are going to be there. Low-hanging fruit, next is vitamin D. If you’re not getting enough sun, or you have darker skin, you’re going to need some vitamin D. Vitamin D plays a major role in th1 th2 balance. And also helps modulate t-regulatory cells which keep your immune system in balance. A lot of studies showing people that have lower, higher vitamin D levels are more resistant to different virus, infections. Our vitamin D also produce an antibacterial enzyme called cathelicidin which helps decrease bacterial load so there’s a lot of powerful benefits of vitamin  D and of course, in the winter months, when colds and flues are at the highest. Guess what? That’s when the vitamin D is the lowest on average because of the sun. So vitamin D is very powerful there out of the gates.

Evan Brand: Man, I just got my blood work back. My vitamin D was like a 45 which is too low. And I was kind of putting a false sense of security I guess into my sun exposure. I mean, I’ll get my legs exposed, my chest, my back. I mean, I’ll be outside for sometimes, couple of hours few hours a day, during the peak hours and my vitamin D was still below optimal. We like poeple give or take, we want to be 60 to 80, and I was at a 45 so I’m back on supplementing 5000iu plus a k1 k2 formula just to try to make sure I get up to that peak where I need to be so if you’re like oh, I’m outside in the garden. Don’t use that as your reasoning for not supplementing. If you have to supplement, it’s okay. Dr. Justin Marchegiani: Yeah, absolutely. And I would just say 50-70 on an average is probably reasonable. If you have an autoimmune isse, or any cancer issues, you know. Being 70-100 is probably even better. But at least 50 I think is good. So you’re not too far away from that but yeah. If you’re like below 20s or 30s, or below that, you get problems for sure. So vitamin D is really good. Obviously, I think next low-hanging fruit is gonna be zinc. Zinc has major effects, zinc fingers have a major effect on your genetics and DNA activation. Zinc also plays a major role in hormones, making testosterone, making uh, stomach acid. So zinc helps with digestion. Zinc helps with on the hormone side, and zinc also plays a major role on helping viral loads. So lots of studies on zinc losses, zinc helps get into the cells, and it decreases virus replication, so we have natural zinc ionophores, right. Their medications that do it but there’s also some natural compounds like quescitin that actually help zinc get into the cells at higher level and zinc, zinc levels when higher can prevent the virus from replicating kind of like NAC. So zinc is a very important natural compound and so is quercitin as well. We could add quercetin and zinc together ro really help flood ourselves with good high quality zinc.

Evan Brand: And we don’t go too crazy. I mean, we’ve had people that are doing like 50-100 milligrams of zinc long term. That’s too much. Maybe on going for females, maybe 10-15 milligrams, males maybe a tiny bit higher but, I had one lady doing 100 milligrams of zinc and she was not feeling good. So that was too much.

Dr. Justin Marchegiani: Yeah. If your’re doing that much probably 50, it depends on the type, right? If you’re doing a crappy like  zinc acetate or something, if you’re doing like a zinc biscynade or eally good zinc bound to an amino acid, probably 50-70 acute like an acute type of situation. But outside of that, probably 10 to 30 max kind of from an ongoing basis. You’re gonna get zinc in pumpkin seeds and a lot of your grass-fed organic meat and or high-quality animal products.

Evan Brand: yeah. That’s the question. I mean, if you’re eating the way we are, I mean, I’m doing a grass-fed steak for breakfast some mornings. I mean, I wonder if I even need extra. I guess it depends on the situation. I will throw a little in; I’ll sprinkle a little in but, it’s not a big one I take all the time.

Dr. Justin Marchegiani: Yeah. I mean it’s more going to be during stress and your immune system being more compromised, your nutrient levels are going to need to be higher and so that’s powerful there. I would say next out of the gates, vitamin C is important. Vitamin C are really important nutrients. Obviously, it has major role in oxidative stress; it’s an antioxidant. I would say the macrophages which are like the little pac-man, pac-woman that gobble up bacteria and viruses in the bloodstream. There’s a docking station for vitamin C on to that macrophage. And vitamin C can help potenciate the strengthof those little pacmen and pacwomen; very powerful. Now vitamin C has a molecular structure; very similar to glucose. Guess what happens if you consume too much glucose or I.e sugar. That glucose can dock on to that macrophase and actually weaken it. And so it’s important when you’re sick and your immune system is compromised, higher levels of glucose will mimic vitamin C and kind of dock on that receptor site and will make your immune system weaker. So keeping your immune system stronger by keeping the glucose under control is important. And then getting that good vitamin C in there is going to be important especially you know, acute right? You can always work on what I call a vitamin C callibration where you get your vitamin C levels up to just before, or just past the point where you have loose stools and then back up until they solidify, and you can do that during acute phase, if you’re sick, to keep your immune system nice and strong.

Evan Brand: I love my vitamin C but, I over did it because then, my iron was too high and I think I was doing like three grams of vitamin C for a long time and I was drinking my vitamin C powder with my grass-fed bison steak so that will increase iron absorption. So for anemic people, that’s a great strategy but, for males if you irons are really high, that’s one thing to consider and just track it with blood. Dr. Justin Marchegiani: Yeah. Retract your blood. You know, the natural solution for high iron if you’re a guy is gonna be therapeutic phlebotomy. So getting your blood tested, giving blood all those things are wonderful out of the gates. So we talked about zinc, we talked about vitamin C, we talked about NAC, glutathione, we talked about vitamin D… Is there anything else we missed there? We can add more nutrient. What would it be, Evan?

Evan Brand: Mm. I would say the B vitamins would be very important because, B vitamins are going to be helping mitochondria; we know that a lot of the toxins and things we’re exposed to damaged mitochondria. B vitamins can help support the kreb’s cycle. So in a roundabout way, I think that would be part of an ongoing protocol. If I wanted to keep myself up, keep myself feeling great, I think some Bs would be in the picture.

Dr. Justin Marchegiani: Yeah, I think some B vitamins are always good. So I think we have vitamin C , D, zinc, NAC, and glutathione so we have five there and we’ll add a little bonus with um, with what you just said with the B complex. So that’s fine right there out of the gates. Why don’t we switch gears and talk about herbal slash compounds? So we have silver, colloidal silver or we use a nano silver so it’s better absorbed; you need less of it. Silver is very helpful because it can it moves through your body; it’s very small in its molecular structure; you’re not going to worry about algeria, or turning blue when you use a high quality silver because, the silver molecules are so small, they flush right by your body and go out through your kidneys, no problem. If you make silver, you have really big silver molecules, you know. Bigger than 20 part per million; like in the hundred per million plus then maybe that can get stuck in yous cells and turn you blue; but most of the archery are turning blue and turning blues and come from home made crappy silver. Uh, we use manufactures that have been around decades, and have never had a case of argyria or turning blue  because one, we’re just using high quality silver and it’s going to be tested, so we know the exact ppm-part per million. And so silver is great. Natural antiviral, and it also um, actually an anti-biofilm; so it actually helps the body deal with bacteria better because it decreases bacterial biofilms, which are the little protective shields if you think of the movie 300, right? The spartans, they have their shield and their spear, right? Well biofilms on bacteria are like the shield, right? So imagine like in the movie 300, you pull away their shields, now they’re a lot more vulnerable to attack. Well that’s what silver does to a lot of these biofilms on bacteria; and so it can allow the herbs that you’re using to actually kill that bacteria better. So silver is really powerful. Conventional medicine is even using silver. They use a lot of silver cellophane now. So If they do a total joint or total hip, or total knee, they’ll actually take the joint and they’ll wrap the cellophane around the joint because they found that it prevents mersa or antibiotic resistant bacteria which is powerful.

Evan Brand: Wow! That’s cool. I didn’t know that. So it’s funny a lot of things we talked about eventually will be mainstreamed. Like we talked about, I think glutathione with nebulizers should be in every ICU especially for long and viral issues and it’s not. So maybe one day that will become true just like the silver.

Dr. Justin Marchegiani: 100%. So we have silver there, I will also hit some medicinal mushroom. There’s a couple that are out there. I mean, I like reishi. There’s some other ones that are really good but, reishi and a lot of these mushrooms one have an affect on in increasing the immune system. Whether it’s usually the th1 immune repsonse, uh some of them can actually deactivate viruses, right? A lot of the beta 1, 3 glucan, or the tritipines that are in there can deactivate viruses. That’s pretty powerful out of the gates.

Evan Brand: Yeah. I’d say turkey tail. I think turkey tail and reishi. Those would probably be my top two. I mean you and I do cycle in some mataki and chaga, and some lions maine. I really love lions main for cognitive issues or for helping with ngf which is called nerve growth factor. I had a woman who had chronic burning tongue for 20 years, and we’re able to completely reverse that using lion’s maine mushrooms. So we suspected it was a nerve injury because after a general procedure, her tongue was burning, and dealt with there for 20 years. Lion’s mane took care of it. So I just love lion’s mane but, for this conversation I think rishi, and I’d say turkey tail would be the best if you are having issues with oxygenation, and chronic fatigue, a lot of people having some post viral chronic fatigue, cordyceps, I love cordyceps mushrooms. I use that quite often as well. So those three would be awesome. Turkey tail mushroom, uh, rishi, and cordyceps.

Dr. Justin Marchegiani: 100%. So rishi, cordyceps, I like other compound like golden seal’s wonderful. I had that on my Gi Clear four. That’s kind of in the berberine family. Um, that’s wonderful. I see a lot of berberines do amazing, working great, barbary. I like golden seal; it gets wonderful out of the gates.

Evan Brand: In what form? What are you referring to the berberine compounds for? What are you talking about?

Dr. Justin Marchegiani: Well it’s an antibacterial. Berberines mix with wormwood. If you look at Stephen Buehner’s book, he talks about that having a very powerful anti-viral kind of synergist? So berberines with artemisia are very powerful there as well so I like that too. I would also say um, astragalus is also powerful. It’s a good blood cleanser, it helps with the spleen, it helps with B cell antibody production; helps clean out the blood a little bit. Any feedback on astragalus?

Evan Brand: Oh, love astragus. I’ve got tons of bottles of it and we made, we made astragalus for, for a long time. We had really good quality source, glass bottle, good stuff. I take astragalus all the time and especially for tick bites. If you’re listening and hey I want to improve my immune system and all of a sudden, I got a tick bite, uh per Stephen Buhner’s protocol, he recommends three grams of astragalus for the first 30 days to really ramp up the immune system. IF you have chronic lyme, though that would be a situation where you don’t do that because it can send the immune system the other direction. So that’s a one of my favorite herbs. I’m glad you brought it up and it’s often the root. Technically, we say the herb but astragalus root is what’s being used.

Dr. Justin Marchegiani: Correct. So we hit astragalus, we hit golden seal, we hit some of our medicinal mushrooms, we hit silver. Let’s hit one more out of the gates. Andrographis is another good one. And again, a lot of these herbs work by one, supporting or stimulating your immune response, and typically, a lot of them are going to work more on the th1 side, so they’re going to really help mobilize natural killer helper cell production and of course, that the also help support antibody production later in the game. And a lot of these herbs can also decrease the virus from being able to replicate. And so that’s helpful because the more replication of the virus we have, the more the symptoms increase. So we can decrease virus load while improving our immune response, then we kind of hit it in both angles. Now, people that are autoimmune, some of these herbs could make you feel worse right? But the way I look at it, as most people are going to be th2 dominant in a lot of these autoimmune issues and so naturally supporting th2 could be a good thing out of the gates. So I always say, work on supporting the nutrients first, and then you can kind of come in there with the herbals come in there one at a time and just see how you deal with them, and then add that to your medicine-functional medicine toolbox later on down the road. So if you get sick, you know different strategies that are going to help you.

Evan Brand: Yeah. It’s a good point. You’re hitting on the multiple mechanisms right? You’ve got vitamin D increasing the immunity, and reducing cytokines storms, you mentioned some of the antimicrobial benefits to it, you’ve got the biofilm support in there, you’ve got the intracellular support with the zinc and the quircetin, you’ve got just the standard immune support with your mushrooms, you’ve got your protection from glutathione and NAC. You know, last thing I’d like to mention on the herbal front, I would say some sort of adaptogen, we kind of talked about this off air.

Dr. Justin Marchegiani: Oh, yeah.

Evan Brand: Adaptogens in a roundabout way, would be very beneficial and that’s something you and I take every single day, as far as I know you do at least.

Dr. Justin Marchegiani: Right here! Ashwagandha is one of my favorites. My ashwagandha supreme. Um, ashwagandha has been shown to be taken long-term, very helpful for immune function, immune modulation. Obviously, ashwagandha can help cortisol surges too. We know that high cortisol stress can decrease you immune function. So if you’re having high cortisol due to some kind of acute response, ashwagandha may be a good solution to help get that cortisol response under control.

Evan Brand: If I had to pick two, I I think ashwagandha is up there. Maybe number three for me. I’d say number one based on what’s going on, rhodiola because of the antifatigue effects, the anti-anxiety, the anti-depressive effects. Also, amazing for hypoxia. For athletes, for anybody struggling with oxygenation issues, rhodiola is amazing. Second, I gotta go with eluthero, I love siberian ginseng, that combo of eluthero, and rhodiola, oh man. Holy basil’s also awesome too! I mean, God! You know we love adaptogens. So I would just say that any or all of those could be worked into a protocol, would provide an extra support to keep you up on your feet.

Dr. Justin Marchegiani: 100%. And also with vitamin D, yeah. Taking vitamin D with k2 is going to be helpful or at least vitamin k. Again, if you’re going to have a tablespoon or two of high quality grass-fed butter or ghee a day, that’s great. If you’re getting any sauerkraut or good greens, that’s gonna be more k1. So you have those good quality fat soluble vitamins in your diet, you’re probably going to be okay. But if you’re not, that’s where it’s good to just have a little bit of vitamin K2 in there as an insurance policy.

Evan Brand: Cool! I think we covered it unless you want to throw any other herbs? And I think that’s a good, good stack though.

Dr. Justin Marchegiani: I mean, yeah. We hit a good amount, you know. Now regards to the amounts, I mean typically we may double or triple that the typical recommended dose on the back of the bottle if it’s an acute type of phase depending on what’s happening. And so that’s kind of a goo I think rule of thumb out of the gates, is at least double or triple for the first few days to a week during an immune response. Evan Brand: Yeah. On going though, for me rhodiola a couple hundred milligrams is plenty for me too much. I get over stimulated, same thing with elutheral couple hundred milligrams typically per day, early in the morning. And ashwagandha, I mean, you could go up to 500 milligrams or so would be I think a great ongoing dose for actually.

Dr. Justin Marchegiani: I think, I think 500 to a 1000. You can go up to 2 grams on that, and again, it matters if it’s like, this is a whole herb right. Some are like a standardized extract but much smaller that could be more concentrated but, if it’s a whole herb you know. A gram to 2 grams is usually going to be fine, a gram on the lower one’s fine.

Evan Brand: Yeah, and we’re not. Yeah, and we’re not making your protocol here, so like if you go and you look at the bottle, and like well this is 80 milligrams of ashwagandha, so I’m gonna go take freaking 40 to get to what he recommended, no. You gotta pay attention like you mentioned to the label. Because like you said, standardized extracts , 80 milligrams could be equivalent to 800 milligrams if you’ve got like a 10 to 1 extract. So you gotta pay attention to your labels and know what you’re getting.

Dr. Justin Marchegiani: And also if you’re really night shade sensitive, and you have a lot of autoimmunity, be careful because ashwagandha is a night shade. But again, if you’re really sensitive to nightshades and via tomatoes, potatoes, eggplants, peppers, then be careful with that. Do it one at a time.

Evan Brand: Yes.

Dr. Justin Marchegiani: So outside of that, today was a great chat. I’m just, for the listeners here, if you guys want to reach out and get specific functional nutrition, functional medicine care, by either Evan of Dr. J myself, feel free to head over, you can reach out to Evan there; there will be a link for you, as well as my site, We are available worldwide via phone, zoom, facetime, we’re here to provide all your natural health services if you need that. Also, click down below, send us a review, give us a little comment on today’s podcast if you enjoyed us. Let us know, kind of put down what immune support is your favourite and what’s been helpful for you in the past. We’d love having clinical experiences shared. That’s how you learn a lot. Anything else, Evan?

Evan Brand: Absolutely. I think it’s, I think you covered it all. Just keep your head up. Keep moving forward. That’s all you can do. So I hope these tools will help people.


Audio Podcast:

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Role of Functional Medicine in Mental Health | Podcast #326

As an adult, maybe you’re struggling with some of these symptoms yourself, things like anxiety, perhaps depression or mood issues, those types of things. Or many of you have kids with these types of mental health symptoms and problems. Functional Medicine is a form of integrative medicine that focuses on addressing the root causes of a person’s symptoms rather than merely treating the symptoms themselves and, in this case, manage stress. Here are Dr. J and Evan Brand sharing their insights about different approaches for stress reduction. 

Dr. J suggested to pay attention to nutrients first and some natural herbs such as ashwagandha, rhodiola, holy basil, etc. Watch the whole video to know interesting details about functional medicine in mental health.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

1:22      Foundation of Functional Medicine Needs

8:27      Emotional Stress

14:50    How to deal with Stress

19:08    Alcohol as Stress Reliever

30:43    Importance of Exercise

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Dr. Justin Marchegiani: And we are live. It’s Dr. J here in the house with Evan. Evan, how are we doing today man? 

Evan Brand: Doing well, the sky is blue, the weather is amazing. I looked at your forecast for this week too, it’s going to be like 75 and sunny all day, every day. So that’s going to be amazing. We’re inside though, maybe we need to do like outside recordings, maybe need to go like, sit out back in a hammock and record with me. So we don’t miss this weather because then it’s going to be cold. And we’re going to be complaining. But no, but long story short, we were talking pre show about just how everything this year has been kind of crazy. And a lot of people are expressing issues with their mental health, their physical health, their emotional health, it’s affecting our clients, it’s affecting potential clients, people that are reaching out to us that have had businesses closed down or potential job losses and a lot of economic issues that have caused a lot of, you know, mental emotional problems for people. So the idea today was, well, let’s try to cover kind of a, a broad stroke, if you will, of how we could use functional medicine to improve mental health. So let’s dive in.

Dr. Justin Marchegiani: Love it. So off the bat, like we kind of go back to like Maslow’s hierarchy of needs, right? That’s kind of like the first thing. So I always tell patients off the bat, there’s kind of a foundation of functional medicine needs, that’s going to be clean water, sleep, and then clean food. And now we can kind of get in the middle of it in the weeds with the food and kind of getting your macros dialed in and getting all that kind of dialed in. But clean water, clean food and good sleep. And so I always tell patients, the more stressed you are, the more you need to be rested, fed and watered. And the more those things are kind of stable, and that’s like your foundation, the better adaptable you will be at the dealing with stress, adapting to stress. So the health, health and stress adaptation are intimately connected. So the more stressed you are, if you start going towards alcohol, and processed food, and staying up too late and watching too much news, it’s going to get that fear cycle going, you’re not going to have enough rest to recharge your parasympathetic nervous system, you’ll be too much sympathetic dominant, you’ll be leaning on your adrenals leaning more on cortisol leaning more on adrenaline, and it’s going to be harder for you to digest. You’ll be just kind of on the edge every time with your emotions, the smallest thing will set you off, and you won’t have a good solid foundation.

Evan Brand: Yeah, I I think people should really just get rid of the social media apps on their phone. I mean, that was something that I did. I just noticed that if I have the social media apps off my phone, and I have to go to a web browser to check them. It’s much much more inconvenient to do it. So I must I’m much less likely to do it. And also, for me, you have the option of being up speaking to that you hear his little notification sound. Oh, social media-

Dr. Justin Marchegiani: – has turned it off right now. Airplane mode, maybe. 

Evan Brand: It’ll, it will, it’s it’s it, you know, there’s been like trials done on how long it takes you to get focused again. And so what I’ve tried to do is to limit my distractions, I think the world now has become a world full of distractions, mainly because people are trying to solve all the world’s problems on their own meaning, you know, I care about the trees getting cut down in the Amazon. So I’m going to go read about this, and then I care about this, I’m going to go read about that. And then you’re so scatterbrained that you kind of lost your own productivity. So I’m not saying that you need to just, you know, put your head in a hole and turn the world’s problems off in your head like they don’t exist. No, I think it’s just a fine line. And I think most people have lost the line of productivity, because they’re so focused on the issues. And a lot of the day to day decisions you make aren’t going to change the world that much like there’s nothing I could do necessarily right this very second, besides maybe donating some money to some organization to stop cutting trees in the Amazon like it sucks. I don’t like to see, you know, you got all this illegal deforestation going on. But there’s only so much you can do. So you got to find a way to to find a healthy way to absorb the media. And most media is negative. So social media, media news. And a lot of it’s not serving you. That’s the only point I have to make.

Dr. Justin Marchegiani: Yeah, I do think number one, social media is a big one, you kind of have to like, use it, don’t let it use you. Right. So turn off the notifications. Don’t let it kind of be there something that you always go to write, I think deleting it from your phone, or at least maybe on the weekends or periodically, deleting it can be helpful because you’re not going to access it as much on the web browser. I think also people forget that most people use social media as their highlight reel. So they only post great things about their life. People feel bad about it. So I’m very aware about that. And I don’t overly post the highlight reel of my life on there because those things are between me and my family and I don’t need to share it with the whole world every now and then. I’ll get people A glimpse, but it doesn’t need to be there all the time. A lot of people overdo that. And people forget that they’re seeing someone else’s highlight reel and they make it makes their life feel a little bit less than or more inferior. And you got to remember that right? You can’t forget it. That gives you kind of a good perspective and a grounding and and it really just comes back to appreciation. Right, the more you’re grounded in appreciation for what you have that that really shifts that that stress and that sympathetic kind of response of just inadequacy and, and, and, and feeling like your life’s not enough.

Evan Brand: Yeah. And there’s people with it, we know that are incredibly successful in business and wealth and all of that. And these people will go publicly bring up their anxiety and depression. So when you look at someone’s life, and you see all they have it so good, I’m so jealous of this or that car, this house or whatever, a lot of people listening may just shut it down immediately. And they say, Oh, no, I don’t care. I’m not comparing myself. But it’s kind of a subconscious thing. You’re not even really aware that it’s happening. Just look up type in, like Instagram depression, there’s some studies done that it was the most depressing social media. So I don’t want to make it the whole anti social media podcast, but you, you hit on gratitude. And I think that’s really the key. So what I tried to do was like a walking gratitude. It’s very, very helpful. So I’ll just, I’ll take the kids outside, and they’ll just walk, whether it’s in the backyard, whether it’s down the driveway, whether it’s in the you know, by the garage, I’ll just find a place to just walk, walk, walk. And I’m just focusing on the motions of the body just shaking up and down, dude. And I’m just thinking, Man, I’m grateful. I’m so grateful. Look at this beautiful day, look at the sun, look at the blue clouds, or the white clouds with the blue sky. Look at the the contrast, look at the green on the trees. Oh, we’ve got a little bit of yellow coming in on these maples over here. This is gorgeous, Oh, look at that red tree over there. And it’ll really take you out of the fear, it’ll take you out of the worry those repetitive, repetitive thoughts, you know, there’s, and this is not talking to one or two people here on my intake form, which thousands of people have submitted, you and I use a couple different form creation tools. I’ve looked at how many submissions we have. And it’s literally like 95% of people out of these thousands have reported? Yes, they beat themselves up with negative self talk. That’s a question on the intake form. Do you beat yourself up with negative self talk? 95%? Say yes. Now is that because you and I have a population who has symptoms and they want to get better? Or is that indicative of the general population to I would say the general population would be the same?

Dr. Justin Marchegiani: Yeah, I always kind of I heard someone say this a couple of years ago, they said, Imagine, you know all the inner thoughts about yourself, kind of write that down. Okay. And imagine if someone else said those things to you? Would you be friends with that person? Probably not. Right? So it’s, it’s amazing how hard people are regarding the inner dialogue. And I always just kind of inner dialogue comes through your brain, ask yourself, would you be friends with that person? If someone else said that to you? Probably not. So I always just try to say to people, you know, make sure you would be friends with the person that would be saying, the inner thoughts that you’re actually thinking.

Evan Brand: Yeah, that’s a good call, that’s a really good call, well, you can be your best friend or you can be your worst enemy. And I think it’s easy to become your worst enemy. Because I don’t know you, you’re the one who has to look in the mirror. Right? So you’re always going to be the one to blame yourself. But.

Dr. Justin Marchegiani: Yep. And if that happens, what do you do? Right? I mean, I think if you have that inner dialogue that kind of shifts overtly negative to yourself, what do you do in NLP world, you go and you visualize the stop sign, right? You don’t beat yourself up over it, you visualize the stop sign, and then you then you shift into appreciation. Or some folks will have the elastic band on the wrist and they’ll pull it tight, right to create that negative neuro Association, whether it’s a physical, elastic snap, or whether it’s a stop sign coming in, that’s that’s visually cueing you to stop, however you want to do it, and then just kind of refocus your energy in a non shameful way to, to the things that you have that are great, right? Because that stuff needs to be you need to it’s like weeds grow automatically negative thoughts grow automatically. It takes no effort to be a cynic. In today’s world takes no effort. It really takes a lot of effort to be an appreciator and to focus on the things that you have. So just kind of use some of those cues to stop the negative thought and then shift over into the positive thought. Now I always find too, if you’re some people, it just kind of feels good to be negative a little bit where you’re kind of venting over something. And if you feel that way, just do it while tapping on some meridian points, some of the EFT meridian points because I find at least if you’re going to be negative, this at least decreases that sympathetic tone. And then what happens is as that that nervous system kind of calms down a little bit, it’s easier to shift back into that positive perspective. So you can do some of the EFT points chin under the nose. under the eye doubletap, I find it’s more efficient for me.

Evan Brand: And as you’re doing this, and as you’re doing this, you’re you’re kind of talking about the negative thoughts, it could be, oh, I just thought about irritable, yeah.

Dr. Justin Marchegiani: Just just talk about whatever it is, I always like to go into it, assigning it a number. So out of 10, 10 being the worst intensity, where, yeah, you had a five or six or seven. And I try to go into it, taking whatever that number is, I want to cut it in half. So if I’m at a seven, I’m going to cut it down to three, or four, if I’m at a six, I want to cut it down to a three, if I’m at a 10 and want to cut it down below five, I just try to go into it, and have that conversation with myself about whatever that thing is that pissed me off, whatever it is that hey, that difficult patient that that really stressful bill, whatever it is, right. And I just kind of go into it, kind of do a little audit of where you’re at, and then try to get that down until it’s at least half below where it’s at, that kind of puts you back in the driver’s seat. And then it gives you the ability to shift to being positive, because you can’t be positive, it’s harder to be positive when you have that emotional staying at a higher level on that on that object subjective scale I gave you. So if you can cut it in half, that gives you the ability now to downshift from negative into positive to enable just want to make that shift. while they’re at a high level of negative it’s too difficult. That’s Oh, man, doing the EFT can be helpful because one, it gives you permission to be negative, but two, you’re giving your your nervous system, a little bit of a bump to be able to neutralize it.

Evan Brand: That is the the best point you’ve made about the emotional stress piece because this is like taking somebody who’s in the middle of a full blown panic attack and saying, Just chill out. 

Dr. Justin Marchegiani: Just chill out, like just relax, like, be be positive, no, can’t do that. Can’t do that. So this is where like the EMDR. And then you can kind of scatter your eyes around while you do it too. Right. So you can go look at like a clock face and go to 1936. Or you can tap while you’re pretending like you’re looking at different clock numbers with your eyes. And because when you move your eyes that uses different cranial nerves, which uses different parts of the brain, and that kind of the whole goal is you’re kind of scattering that signal. Number one, you’re interrupting the pattern. Number two, it’s kind of like if you’re talking about something you ever had it where someone interrupted you and you’re like, What the hell are they talking about? Right? ever have that? That’s kind of what you’re doing a little bit to your brain and in some of the negative thinking you’re trying to scatter that pattern and make it a little bit harder for your brain to go back to and then you’re like, what, what was I mad about? Oh, yeah, that. And then it makes it easier than shift into positive.

Evan Brand: I just tried to go outside to like, for some reason. Well, duh, I mean, humans were meant to be outside. We’re not meant to be in boxes all day. But you know, if you have a thought that is intrusive, you can just go out, and I’ll take a pair of binoculars, and I’ll just go outside and I’ll just watch the birds. Or I’ll go fill up the bird feeder, put it like a sewage feeder. So it’s like a big chunky like fatty CD type feed. I like to go put that out, watch the woodpeckers come in. And if I’m looking at them, and I’m not thinking about anything, yeah, that’s a that’s a great point. So let’s tie the functional medicine piece into what you said because I think what you said is a really good place to pivot which is you can’t take someone because someone listening who’s just so stressed out right now they’re going to they’re going to listen to you talk about tapping or if they’re watching the video on YouTube. So you tap into right What is this guy doing? He’s friggin tapping his forehead. I’m so pissed. I don’t care what what is this gonna do? That person’s a 10. He can’t he can’t even comprehend getting down to a five right now. So So on the maybe you would call it the herbalist functional medicine side, maybe we come in and give that guy or gal a shot of passionflower. Or maybe we give them a couple hundred milligrams of some pharma gabbeh or maybe a little bit of mother wort or maybe some ashwagandha maybe some Holy basil. Maybe we come in with some B vitamins because you and I know based on looking at thousands and thousands of people on organic acids testing that if you’re really really stressed, you’re going to burn out your bees as in Bravo, your B vitamins are going to be toast we know that. Based on looking at these labs, your neurotransmitters are going to be affected. So you may have low dopamine, you may have low serotonin, which is causing more anxiety, but then the low dopamine is causing a lack of energy and lack of drive. So let’s dive into some of these more functional pieces now.

Dr. Justin Marchegiani: Yeah, so we talked about the mindset stuff. We talked about tools to kind of decrease that sympathetic output and it’s just tapping on meridian points, right acupressure acupuncture points, kind of how energy and nervous energy Nervous System energy flows to the body. It’s just helping that energy flow better whether you call it ci or whether you call it action potential or, or nervous system, nerve flow, whatever you want to say, right? blood flow. It’s all connected, right? It’s all connected, right? So off the bat, we were talking about functional stuff. So when you’re stressed What are important things? Well, blood sugar stability is really important because most people get on a rollercoaster of blood sugar. When they get stressed meaning they’re going they’re overly gravitating towards alcohol, or overly gravitating towards refined sugar, their blood sugar goes up and then crashes down. And then it creates more nervous system stimulation via adrenaline and epinephrine being stimulated. And cortisol being stimulated to bring your blood sugar back up. So I find just keep it really simple, really easy with your meals, you may be more nauseous when you’re overly stressed because stress hormone does cause you to feel nauseous. So this is where you may want to do a soup or a simple smoothie, something really easy where there’s not a lot of digestion, but you’re still getting some proteins and fat in there. Whether it’s some collagen and some coconut milk or just sipping on some bone broth, right, something like that is going to have some good fat protein and it won’t be hard to digest. So if you feel nauseous just still no you should probably be eating but just try to make it something very easy on your tummy. And then think what are some of the nutrients your nervous systems in need when you’re more stressed, so low hanging fruit, B vitamins B complex is going to be very essential. Magnesium is going to be excellent gabbeh l-theanine these are good things that are going to help you relax and wind down having kind of mentioned valerian root or passionflower which are all connected to gabbeh and that kind of inhibitory neurotransmitter that helps you just relax a little bit kind of kind of puts the clutch in gear disengages the the gearbox so you can kind of downshift so to speak.

Evan Brand: Did you ever do Kava when you were down in Austin?

Dr. Justin Marchegiani: Yeah, so I mean, I’ve done I’ve done Kava still. 

Evan Brand: Did you go to the bars though? There’s like a cot. There’s like a cup. 

Dr. Justin Marchegiani: Oh, no, I’ve never I’ve never done it at a bar, but I’ve done it. Um, someone brought it over my house. They got it from Fiji. Before I did, it was relaxing. I like Kava that does a lot of gabbeh too, right?

Evan Brand: Yeah, does I felt weird my throat. I felt like well, am I having a reaction to this? Like it numbs your throat so much. It was a bizarre feeling. Yeah, I’m not recommending it. I’m not recommending it as a as a tool. But it could be it could be a good tool. I just thought I’d bring it up. Because when you mentioned like, Valerian I thought, Man, I remember that one time I drink Kava. I was. It was a weird, almost like an out of body relaxation. And I didn’t feel very grounded. It was kind of like whoa, I’m floating in the room. Kind of kind of interesting. 

Dr. Justin Marchegiani: Yeah, I mean, like I always go to nutrients first. And then I go to my favorite adaptogenic herbs second, so ashwagandha is one of my favorites. Right? ashwagandha rhodiola. Excellent. Excellent x, Holy basil those are kind of like my favorite kind of very relaxed, defying, relaxing tonifying kind of herbs, if you will.

Evan Brand: I like it too relaxefying, Do you get any sort of change in your outlook with holy basil? Because for me, that’s the one that’s most significant. Like I feel like I could take on the world when I get like a, I don’t know five 600 milligram a holy basil. It’s kind of like I am ready for the challenge. It’s a weird because it’s I’m calm. But I’m also energized at the same time. Do you get anything like that? 

Dr. Justin Marchegiani: It hasn’t been on my stack for a while. So right now my big stacks on my desk is going to be ashwagandha I do have some some gabbeh chewables and gabbeh sublingual. I mean, I think if you just took people’s works and took, you know, in their, in their place of work, whatever. And you took away all the candy and you just put like magnesium, and you put gabbeh like Lawson jers. Right. Think about how much of a stress reduction had been people’s works. Right. So much better. Maybe some B vitamins.

Evan Brand: Yeah, I mean, if you and I had brick and mortar places what I would do instead of a little you know how old school like front desk, you’ve got a little glass of like lifesavers and peppermints. And a bunch of garbage. I’d have like pre packaged chewable pharma gabbeh sitting there.

Dr. Justin Marchegiani: Yep. chewable pharma gabbeh, sublingual magnesium, maybe some l-theanine shots, right? keep it really simple. I remember in doctor at school before. For finals, we would like make drinks of like ginseng and holy basil. And we like create these like shot glasses all lined up with herbs where we take it. It was fine. I mean, those are some fun times. But um, yeah, so we just got to think a little bit differently and how you deal with stress, just a different mindset change.

Evan Brand: Yeah, I want to go back to what you said how people get into the alcohol and to the sugar and all of that and the carbohydrates and the blood sugar rollercoaster. I think people don’t understand why that happens. So I just want to give people a brief education of why that’s happening from a, you know, neurotransmitter perspective, that way you feel a little more confident that you can change this and you’re not just a victim to the food. So when we look at urine and you measure these neurotransmitter metabolites, we can see that after a period of stress, especially if somebody has been working with us for several years, we can see that Oh, they went through a divorce. Look what happened to their endorphins, for example, the endorphins got burned out. And with the help of Julia Ross, she has an amazing amino acid therapy chart in her books. You can see that the symptoms of low endorphins start to pop up. So these are the people that cry at the drop of the hat. These are the people that hard on the sleeve real emotionally sensitive. If they crave dark chocolate, they’re going for food to comfort themselves or reward themselves. Those are low endorphin signs, we’ll match up those symptoms to the neurotransmitter report on the oat. And then we’ll come in with a therapeutic nutrient like dl phenylalanine, to rebuild the endorphins. And then within four to six weeks, you can have it the 60% difference in symptoms were these people that were running to the cookie because they were stressed or running to the alcohol at night to relax, they no longer need that now, they may still do it. But they literally don’t have the physiological need to do that. Some people say, I just can’t relax until I have that glass of wine. Once you rebuild the brain chemistry, they literally don’t need it anymore.

Dr. Justin Marchegiani: I mean, if you’re having a stressful day, I mean alcohol Don’t get me wrong is that is a wonderful downer. I mean, it really does help relax people. Now obviously, if you’re going to engage in alcohol, keep it to like a drier champagne, a drier white wine, keep it to a clean alcohol and try to do it after you’ve eaten. So you’re not creating a blood sugar swing, because alcohol can actually lower your blood sugar. And then that creates more cravings and more cravings for junky food, right? So if you’re going to have a glass of alcohol, right, don’t want don’t get drunk. But if you’re going to have a glass, make sure it’s a healthy version, then just try to have some good protein before you have it like so if you go out, for instance, have some oysters, maybe a little bit of seafood, maybe a shrimp cocktail and have a glass of champagne or two or a cabo or Prosecco or something clean, clean, clean alcohol. There’s nothing wrong with that, you know, especially if it’s only if it’s not an everyday kind of thing. I think it’s totally fine. And you know, make sure you’re utilizing some of the nutrients we talked about. So you’re supporting the neurotransmitters as well.

Evan Brand: Yeah, check out our podcast, we did a whole one on the whole biohacking alcohol thing. 

Dr. Justin Marchegiani: Yeah, that’s how-

Evan Brand: So, Sunshine, sunshine is huge. I mean, granted, when you’re in certain parts of the country, you really lose the sun, you really lose it because you get clouds. And, you know, if you’re really high northern latitude, it’s really tough to get sun, I’ve got a lot of clients in Canada, and they just get major, major seasonal depression. And so for those people, like a light therapy box can be helpful. I already know for me personally, it’s affected me like when it gets dark at five 6pm. I mean, I just mentally, I just don’t like it. And so the light therapy box can be very good. A lot of times, you’re going to see those at around 10,000. Lux, that’s a pretty bright, pretty bright light. Of course, nothing is going to beat the sunshine. But if it’s like you’re in Alaska, you literally or, you know, hours of sun per day, whereas before it was 12 hours, and now you’re three hours of sunlight. That’s really tough mentally, so sun can be helpful. I wish tanning beds weren’t so controversial. because years ago, I had a friend who worked at a gym who had a level, I think they called it a level three or level four tanning bed, which was not something that closed on you. It wasn’t like magnetic field balanced. Like I measured it, there was no EMF coming from it. But it was almost like the stage lights, almost like a like a theatrical performance, like a red light up at the top. And you could get a tan, I mean, literally in a couple of sessions. But I did it for mental health. And we know that sunlight in general can really help act as almost like morphine, it can really help modulate these opiate receptors in the brain. I remember coming out of a six or seven minute session, and I was just high on life. I felt so good after that. And I thought, wow, I wish this didn’t have to be so controversial. Because if someone could get access to something like this, if we knew that it wasn’t going to increase risk of skin cancers and such, man, what could it do for all the depressed people out there that have Seasonal Affective issues in the winter?

Dr. Justin Marchegiani: Yeah, I think it just comes down to when you’re dealing with sun, it’s just don’t burn, you know, just just don’t get a burn and you’ll be fine. And that’s different for every single person. And so of course, you know, natural sunlight is going to be ideal. I think it’s gonna be excellent. So that’s a good first step for sure. We talked about some of the B vitamins and things and it gets really essential. I think also, you know, just from a financial standpoint, I think it’s really, really good. People talk about it, just having that six month emergency fund, right, try to have, you know, six months of being able to take care of your family, whether it’s food, living mortgage, just try to really make sure at least three to six months if people had that during COVID. I think there’d be way way, way less financial stress for people. I know, it’s a tough thing to do. But I think it’s something to strive for in regards to financial health is just really look for that six months, three to six month emergency fund. I think you’re smart.

Evan Brand: Yeah. And try to get rid of things that you don’t truly need. I mean, I had several people who say oh, you know this or that about budget, but they’ve got the hundred and $40 a month cable bill and they’ve got the the you know, the subscription to this or that that adds up to hundreds and hundreds of dollars a month. So I think with the reducing subscriptions where you can the emergency fund is smarter than from the food security perspective. Two, I remember months ago, you and I were talking about this it was there was talk about some of these meat processing plants and stuff shutting down and I had literally some of my clients freaking out thinking that they were going to run out of meat and not be able to feed their family. I mean, they were probably just watching too much news about the subject. But that’s why I always recommend everyone have a good chest freezer, you can get him for $100 and go on local harvest or eat wild, or just Google local farms around you, we have a farm that I pay him a little bit extra, but they’ll deliver to the house. And we’ll have literally an entire chest freezer full of amazing grass fed meat at anywhere from six to $10 a pound depending on the cut. And we don’t have to worry about going to Whole Foods where we’re going to get shamed if we don’t want to wear a mask, and then we’re buying their overpriced stuff sitting in the fridge. I’ve got my local farm, you know, bringing pastured meats at a fraction of the cost to my door, throw in the chest freezer, I sleep great at night knowing that if something were to happen to the food supply, my children and my wife and I will be well fed. And then of course well what if the electrical grid? Well, I don’t know. That’s that’s, that’s pretty slim chance. I know, people in California worried about that earlier this year, because of the fires, people were thinking, well, what if I have the chest freezer full of meat? And then the electrical grid goes off? Because California turns off my power generator? You know, hopefully, it’s not a long term thing. But you just got a problem solution problem solution, you can’t just get paralyzed by the problems.

Dr. Justin Marchegiani: Yeah, absolutely. You know, I always talk about it, you got to close the loop, right? You know, you have a problem. When you don’t close the loop. And you think about the solution, and you keep these loops, I call them keeping these loops open. That’s where stress happens when you close the loop. That’s where you feel a lot better, because it’s our problem solution. Problem solution, you’re constantly opening and closing loops all day long. That’s kind of how you want to think about it. So you have maximal you know, stress reduction. So we talked about physiology, right? That’s the foundation because remember, that’s like the this is the vehicle This is a suit, the biochemical suit we have to walk through every day and not everyone’s suit is the same and how we can deal with stress. So if you’re looking coming into this, you know, 20 minutes late, you’re like, Well, what do I focus on, focus on the physiological biochemical suit, because that gives you the ability to adapt. And then from there, you can try to grab one or two things that work best for you. mindsets, really important, dealing with some of these stress can be helpful. Talking about some of the supplements can be helpful. Making sure you’re in a good kind of financial situation can be helpful as well. You know, those are all good kind of strategies out of the gates. Anything else you want to talk about functional medicine wise. So we talked about some of the organic acid testing and looking at neurotransmitters that can be helpful, because I find people that are, you know, let’s say long term stressed out people, we’re going to see a lot of neurotransmitter patterns that are pretty depleted regarding amino acids and dopamine and adrenaline and serotonin. And that may be a longer thing you have to work on replacing with amino acids. So that may not be just a supplement you want to dunk on, they may take a while to work on depleting that, especially, you know, the faster it happens when you work on all the sleep stuff and the diet stuff that gets better, but that the bucket that may need some effort to work on depleting.

Evan Brand: Yeah, the only other functional medicine piece we’re going to be looking into for these like super stress, people’s looking into the gut, we’re going to be looking at gut inflammation. We’re going to be looking at parasites, bacterial overgrowth, all the stuff we normally talk about Candida, because there could be some more functional reasons why someone is going into the cookies, for example, or the alcohol, maybe on a neurotransmitter test, they look okay, but in regards to their gut, maybe they have all these bacterial pathogens are parasitic pathogens that are kind of like begging for some sort of quick burning glucose, right? So we may come in. And I noticed personally just using some Mimosa, I was doing some experiments with not not the orange juice cocktail thing, but actual most of the seed most a tree seed in capsule form. That’s very beneficial for calming down my gut. And I noticed mentally I was calm, just by calming down my gut. So don’t forget about the gut brain access, there is a connection there. And so if you’re having digestive problems now, whether that’s due to stress, or whether it’s due to infections, if you’re having diarrhea or constipation, or stomach cramping or food intolerances, you got to try to address those because it does signal and alert Danger, danger to the brain, meaning if you’re going and eating this allergenic food, irritating the gut that can then irritate your brain and cause issues. So I’ve had some people that have gotten anxious after certain foods, and we know that histamine is a neurotransmitter as well. So if you’re having histamine reactions, even just something like a low histamine diet may be useful to help calm the brain down because of some of the reactions there with histamine. So people think it’s just histamine allergies. No, but it can also affect your brain chemistry. And so you got to focus on that maybe herbal anti histamines or something we would use or some enzymes to help to reduce some of the effectiveness of the histamine on the brain. So I think that’s probably my last piece.

Dr. Justin Marchegiani: Yeah, and those are all valid points. For sure. You know, you talked about histamine, you talked about inflammation, and inflamed brains not going to focus and not going to do as well. So again, inflammation, whether it’s food allergens or deeper gut issues is a big one. Also medical palsy women, you know, lower hormone issues can affect the brain. So try to make sure your hormones are at least at a good stable place because that’s going to help with brain inflammation that’s gonna help with cognitive stuff as well. So everyone’s coming at this from a different place from from a different foundational weakness. So just try to figure out where you’re at and take at least one or two steps, you know, Ford on that. Also exercise can be helpful. So just try to find a couple of movements, simple movements that you can do 510 minutes, that’s going to help really decrease a bunch of stress. So whether it’s a push movement, a pull movement, a set or squat, a bender, a pole, whatever that movement pattern is just try to engage in some of these simple movements, it’s going to really help your mood, it’s going to take a lot of that mental energy and allow you to kind of put it out into that physical movement pattern.

Evan Brand: Oh, 100% Yeah, exercise is key. I should have mentioned it earlier. I mean, I feel amazing after I just do some dumbbells or roll machine or hike in the woods, hike in the field, you know, whatever I could do to move. I mean, that’s in its free, right, it’s free, so and you don’t need any permission to do that. So obviously, if you’re going into a gym and you’re doing the whole mass thing in a gym, maybe that’s not as fun so get outside go somewhere where you know, you have your own space and you don’t have people you know, breathing down your neck, so to speak. But I think with the gut piece, the neurotransmitter piece, the aminos here’s kind of the the summary of today and what’s been going on in the world. A lot of people are just like, hey, things are crazy, I give up. But this is actually the time where you really want to dial things in even more. This is a time where you want to focus even more to keep your body keep your mind keep your your sleep patterns healthy. This is not a time where screw it I’m going to go off the rails and just drink a case of beer. It This isn’t the time to do that a lot of people they’re so stressed they have no other coping mechanism. But I would argue everything you and I’ve been talking and doing and preaching and clinically doing for people. This is kind of like the showdown This is like okay, what did all that work we put in actually do did we were we the last man standing, meaning everyone else got burned out and ended up on you know, anti anxiety medication. And we stayed calm and cool through the whole thing. I think this is the time where you can see all the hard work paying off.

Dr. Justin Marchegiani: 100% I think you’re totally kind of dialed in. Also, one thing I’ve been doing a little bit is a little more meditation and just keep it really simple with breathing. Just focus on breath, you can do kind of a biofeedback device like the Muse that I’ve talked about, we’ll put a link down below for that. That’s one thing I’m experimenting more with. It just kind of gives you that little bit of a thumbs up from a biofeedback standpoint that you’re you’re you’re putting your brain in a pretty good place when you’re meditating. I think it gives people confidence. They’re doing it right. The problem I find with meditation, people are like, Am I doing this right? And there’s just insecurity and what the heck they’re doing. And then that prevents them from being compliant with it. So I think having a extra kind of pat on the back yet you’re doing the right You’re doing good with a some kind of a device that helps whether it’s whether it’s HRV, or the Muse or M wave type of technology, these kind of things I think are helpful to give you the confidence that you’re doing something right.

Evan Brand: Yeah, yeah, the floatation tank is awesome. So doing doing a float would be good. deep tissue massage would be great. calming essential oils would be great Epsom salt baths would be great is anything you can do to downshift. We talked about the shifting phenomenon quite a bit, but-

Dr. Justin Marchegiani: There’s a lot, there’s a lot of options for sure.

Evan Brand: Okay, cool. Well, let’s wrap this thing up. So if people need help, we’re here for you. We always have been and we intend to be kind of on the front lines, helping people with all this stuff. So if you need to reach out to Dr. J. is the website. If you need to reach out to me, is the website and we’re here for you. So don’t give up. Don’t give in. You got to keep pushing forward every day, you still got to put your pants on, you still got to do the thing, whether it’s take care of your kids take care of your wife, your husband take care of career, you still got to move forward. So I know it’s easy to get kind of stuck and like you mentioned I like the idea of the open loops closing the loops. I didn’t get stuck in these open loops, but you got to close the doors. Try to simplify try to you know, minimize decision making focus on the big things and you’re going to be just fine.

Dr. Justin Marchegiani: I love it. Excellent and Well, great podcast today to reach out to Evan, to reach out to me we’re available worldwide. If you want to dive in, look deeper at your physiology, biochemistry, neurotransmitters, gut whatever the root issue is. We’re here to help you guys have a phenomenal day. Click down below for all the important links, guys. Take care. Bye.

Evan Brand: Take care now. Bye bye.


Audio Podcast:

Natural Herbal Support to Help Reduce Inflammation | Podcast #323

Inflammation is our bodies’ natural response against infection, injuries, wounds, and other forms of harm. However, inflammation can cause problems too. It is when some conditions are causing continuous inflammation resulting in tissue injuries along the way. 

In this podcast, Dr. J and Evan Brand talk about some herbal remedies that might help you deal with yours or gear you to avoid unnecessary inflammation. Although there are anti-inflammatory drugs available in the market, some of these lead to unwanted side-effects or, perhaps, not useful. 

For people with inflammatory issues, it’s also good to consider natural herbs to manage it. Some natural herbs you can try are turmeric, ginger, and green tea since some evidence claims its effectiveness. These are generally safe, but it’s still good to consult or discuss this with your physician to make sure that it fits you.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we  cover:

1:27       Natural Herbal Support for Inflammation

4:09       Key Ingredients for Reducing Inflammation

11:08     TNF Alpha Pathway, Cox Pathways

16:54     “You are what you digest from what you eat”

18:03     Natural Cortisone & Natural Anti Inflammatory

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Dr. Justin Marchegiani: And we are live. It’s Dr. J here in the house with Evan Brand. Evan, how are we doing today man? What’s going on? 

Evan Brand: I’m doing good. I’m feeling better. I don’t think I even told you about this off the air. But I had a bat house on the side of my house. 

Dr. Justin Marchegiani: A bat house? 

Evan Brand: Yeah, bat house. Yeah, to try to get to try to get some bats to basically, you know, take take residents there. So they would eat all of our mosquitoes. And they never came. And I was up on the ladder. I don’t know, this may be two months ago now. And I was up on the ladder. And I was unscrewing the bat house from the house. And as soon as I did that, I noticed it was a wasp nest in there. And as soon as the, as soon as I saw that, a wasp landed on my hand. And last time I got stung, it hurts super bad. And so I wasn’t thinking straight, I thought, okay, there’s a wasp on my hand, I’m gonna get stung, it’s gonna hurt, I might shake my hand and fall backwards off the ladder, this is really bad. So I just turned around and just jumped. And it was probably not crazy high, but maybe eight feet up. And I just jumped and just tried to like, you know, cushion my fall as much as I could and kind of roll after I landed on the grass. But ever since then, man, I’ve had a little bit of some cervical, I probably need to see a chiropractor. I haven’t yet but I’ve had like some cervical tightness. And if I sleep the wrong way, it like flares up the cervical tightness. And so I’ve been using some herbal anti inflammatories and nutrients that we can dive into to help me. But I wanted to tell you that and see if you had any other suggestions of things I should be doing. 

Dr. Justin Marchegiani: That’s really great. Yeah, so we’re going to be talking all about inflammation. And we’ll be talking about natural herbal support to kind of help her natural functional medicine support to help kind of reduce that inflammation. Now, structurally, in your situation, there’s probably some level of inflammation directly to that area. So some level of soft tissue, whether it’s active release technique, or myofascial just to kind of help with that tissue. Because when it gets strained or damaged or inflamed like that, it can get a little bit fibrotic, you can get some scar tissue, it can maybe lose some blood supply and oxygenation. So getting some good movement in that tissue to kind of help with oxygenation, make it more pliable, helps making sure those joints are moving well. So really good chiropractic adjustments through there to make sure everything is moving well, alignments, good. So those are the first things out of the gates that I’d be pursuing. Outside of, you know, just some good soft tissue support in your own like a good massage guns helpful just kind of day in day out. And then seeing good massage therapists, maybe some red light to kind of reduce inflammation, too. I think that’s great out of the gates. And of course, you know, we can kind of go into all of the different natural anti inflammatory, inflammatory support that we use typically in practice, and we’ll talk about what what you’re using already as well. 

Evan Brand: Yeah, I appreciate it. I need to get back in touch with my myofascial lady. I just haven’t reached out to her yet. But I think she left town for a while. So she’s still around. I should probably try. I just got fearful I thought, Oh, god, what did I do to my spine? Am I screwed forever? You know, you hear about these people having like car wrecks. And you know, my wife used to work in a chiropractor’s office, and she would see people that were injured from 20 years ago. And I’m like, ah, why, like, surely it doesn’t have to be that way. And I think we have some good strategies that can definitely shorten the recovery timeline. Let me just talk about the topical aspect first. This one thing’s been very beneficial. It is a company called Ned. Hello, Ned is their company. And they actually just send it to me like a year ago, just as like a free Hey, we want you to sell our products. Here’s some free stuff to try out kind of thing. But I loved it so much. I bought more of it, but it’s called a body butter. And it’s just loaded with CBD oil and frankincense and a bunch of other essential oils. It has Arnica in there. So this is just a topical body butter. And I tell you, if I put that stuff on, it’s a significantly reduced pain. And my range of motion is almost 100% if I’m using that topically, so CBD Arnica frankincense, you know, something like that a good blend, or if you like by that body butter, that might be a good option topically.

Dr. Justin Marchegiani: I like that. That makes a lot of sense. So out of the gates, what’s the first thing so more than likely you get some kind of a mini whiplash? I’m guessing you kind of fell more into flexion. Right? 

Evan Brand: Yeah, yeah. 

Dr. Justin Marchegiani: So you probably had a little whiplash because you probably went forward and then your body had to like kind of seize up to kind of stuff that forward flexion and so it probably just strained you probably had a little spray sprain strain in those back ligaments in the neck. And so getting some good soft tissue out back there will help making sure that joints are moving appropriately will help the problem with like ligamentous tissue, it’s more a vascular, right, you don’t get great blood supply. Or like if you strain your muscle like a muscle belly issue, right, it’s going to heal a lot faster because that tissue is just more vascular, it’s got a lot more blood flow. So anytime you have a vascular tissue, you really need good soft tissue support to really help break down and break down fiber optic tissue, scar tissue and then help that will improve oxygenation and that will improve blood flow. And of course, you know, soft tissue and or red light therapy are all going to be amazing things to really work on the on the blood flow and the inflammation reduction aspects. So that’s good out of the gates. And of course like my good thing in my line, we use something called curcumin supreme. Which is a liposomal curcumin, I like that. I think that’s excellent because it has natural anti inflammatory pathway. So like the big inflammatory pathways that you’re going to see a lot of the medication use are going to be the Cox pathways right cyclo oxygenase pathways. And so like cyclooxygenase, two and cyclooxygenase one are going to be some of the big ones right? Now we can do natural herbs to kind of help produce Cox one and Cox two. So Cox one typically will be reduced by things like aspirin or n sets the problem with these things that can be a little bit more irritating to the liver into the gut. So maybe acutely, it’s okay, but chronically not the best, right? And then we have Cox two as well which these were like the old fashioned, like Vioxx drugs, remember, those, like 15 years ago, caused a lot of stroke and heart issues. Those are like our Cox two pathways. So Cox one and Cox two are some pretty good ones, that major pathways. And of course, we have like our prostaglandin e two, which is an inflammatory pathway as well. And prostaglandin e two is what drives constriction. And it’s what causes more platelets and more stickiness to happen. And so we want to work on reducing some of those pathway. So we want to knock down prostaglandin e two, what’s the best way to do that? Well, high dose fish oil or fish oil in general, of course up a really good whole food, pasture fed kind of paleo templates, it’d be great. And you’re going to reduce a lot of inflammation coming from conventional meats. Again, healthy grass fed pasture fed meats better, right? Less arachidonic acid, which feeds that PG net prostaglandin to pathway, of course, keeping the insulin and the grains and the refined sugar, all that crap in check, all of that inflammation feeds these Cox two and Cox one. pathways, right. And so we want to inhibit those pathways, we want to block them. So more Cox one, Cox two, the more inflammation is going down those pathways. So all the dietary crap sets the table, like my analogy is, imagine you walk into a kitchen and the gas is on the burner. Okay, let’s say it’s been on for a couple hours you smell it? Well, let’s say you pull out your lighter, right? Just a little spark, boom, how’s it gonna explode? Okay, but if you did it without the gas there, no explosion? Well, it’s the same thing. If you have the gasoline going, that’s a systemic inflammation from all of these things we chatted about, that allows the little spark of an injury like that, to set off this whole inflammatory cascade, that’s going to be a lot more, let’s just say amplified in the wrong direction, if you will. 

Evan Brand: Yeah, that’s, that’s a great analogy. So let’s kind of spotlight some of the the key ingredients that we use here. Now some of these we can provide to our clients and to me personally in blends, and then some of them we can do in isolation. So I think the the best one or kind of the best combo for me is really some of the enzymes and then plus tumeric and the boswellia I think that’s been kind of my game changer because I noticed that when I added some extra serapeptodase into my system, I have a blend, I’m using the has some in there, but when I added extra serapeptodase, and also some lambro kinase, my issues, definitely, I would say I felt definitely more mobile, like I have more blood flow. And then of course, my hands and feet were warming up too. So I just know from like a circulation standpoint, that that’s also helping and then we know that tumeric has like an anti coagulating ability. So whether it’s like a tumeric tea or like you mentioned a life was almost a product or even just like a standardized curcuminoid product, something like that is going to be awesome.

Dr. Justin Marchegiani: Yeah, I like it. So if we kind of break things down by Cox one, Cox two, there’s also the locks pathway that’s like the the leuco trying pathway or the light bo oxygenase pathway. Alright, so lipo oxygenase versus cyclo oxygenase. These are both going to be inflammatory pathways. So if we start with like the Cox, one pathways, things like ginger are also going to be very helpful in that. So ginger is really good. Excellent. You can also do things like you mentioned lumberg kinase, or serrapeptase, that’s gonna just sit in your bloodstream, you’re taking it away from food, it’s not like a digestive enzyme. And that’s going to help hit all these inflammatory chemicals that are in the bloodstream, it’s going to start breaking them down and digesting them. And we already talked about the fact that we have a lot of platelet aggregation. So what that means is over time, those platelets are going to increase scar tissue and in decreased blood flow. So what are the enzymes are going to do is they’re going to break up those platelets isn’t help improve blood flow, improve oxygenation and improve nutrition. So and it’s also going to decrease scar tissue formation. So part of the enzymes are helping blood flow. They’re reducing. They’re increasing oxygenation, and they’re reducing scar tissue so then it helps a lot of the other nutrients also work better. So we already talked about like, some of the Cox one stuff is going to be ginger. We talked about that already. Some of the Cox two things are going to be things like curcumin, lipids, omo curcumin, and my line I have one called Curcumin Supreme, which is a really good one. And then you already mentioned a couple things earlier like Frankincense or boswellia. That’s also going to be another cyclo oxygenase ACE inhibitor and the thing I like about boswellia or frankincense, it’s the same thing. By the way, guys, frankincense is the essential oil version of that frankincense, you can kind of put topically on it. And then you can also take boswellia internally, so you can kind of hit it from both ends, which is really good. 

Evan Brand: Yeah, also omegas, I am boosting up my omegas, I’m doing about five grams per day of pure omega, that’s my formula. It’s a triglyceride form of omega as it works amazing. And then also, I’m doing extra course attend, just to really help you know, I’ve had some histamine issues after getting exposed to mold. So for me, I do course attend with an enzyme, there’s a special enzyme we use, it’s a course it’s an enzyme blend that I love. And I actually may start manufacturing it soon. But for now, I’m just mixing these. And the course attend for me is a mast cell stabilizer. Now I don’t know about like trauma, necessarily physical trauma, aggravating mast cells and creating a histamine release. But it would make sense if there’s a stress response from the body, you may be pulling out more histamine, I’m thinking of like a, I don’t know, a car crash or some sort of immediate trauma, you’re probably going to have some histamine to really help increase inflammation, but overall, you don’t want that long term. 

Dr. Justin Marchegiani: 100%. Yep, that makes a lot of sense. So there’s other pathways you mentioned, right? So the course attend, like you mentioned earlier, that’s going to help with the TNF alpha pathway. So TNF alpha is another inflammatory cytokine. So think of a lot of these cytokines are like inflammatory chemical messengers, we have cytokines, we have interleukins, we have nuclear factor, Kappa beta, we have TNF alpha, these are all these chemicals, signalers. And so when we have inflammation happen, these type of chemical messengers can amplify inflammation, the effects of inflammation, systemically. And the problem with inflammation is it’s helpful in the short run, because it helps drive blood flow and helps the healing repair process. The problem is, is when it hangs around too long, right? So for like an acute injury, it’s probably good. I think part of the reason why that pain and inflammation is there is to keep you on your butt, so you’re not continuing to damage that area. So I think part of it is, it’s Hey, you hurt yourself, let’s kind of like rest a little bit right part of its that it’s also going to aggregate a lot of immune cells to help heal the injury, preventing infection, it’s also there to help with healing the body up, right, because the body is not about performance when it’s injured, it’s about band aiding the crap out of that area. So the problem with that is the body doesn’t care if it laid down a whole bunch of scar tissue. And that area is now going to be less flex, less flexible, and less mobile. It just wants the body to heal. So now you have to say, Well, I’m also interested in performance too, right? So then you have to look at the fact that like, Okay, I’m going to reduce inflammation, I probably should still be more mobile, I’m sorry, less mobile moving less, because my body wants me to move around less. I’m reducing the inflammation, pain naturally. But I still have to make sure I don’t overdo it. So you have to make sure if you reduce the inflammation, you still don’t overdo it because your body’s creating that pain to keep you from not moving as much. You probably want some movement, but not as much to hurt yourself. And then number two, you really want to remodel that inflammatory scar tissue. And that’s where you know, massage, soft tissue work, adjusting, maybe some some rolling, some foam rolling, gentle things like that to kind of help realign that soft tissue. So it’s more functional and structurally stable. That’s better in the long run.

Evan Brand: Oh, yeah. Good point. I forgot to mention that. It’s not called the Theracane but it’s similar. I’ve got this wooden like cane from like a physical therapy office like it’s a, it’s a wooden cane basically, and it’s got the wheels on it. I’ve been kind of digging that into my upper mid back area kind of work in my traps. I’ve been just doing some light stretches. I’ve been doing some lateral pull downs, I love lat pull downs, I’ve been doing some seated rows. I’ve been doing my roll machine. So just gently trying to work the area. And I do that after I take these enzymes. And I do notice that it definitely warms up the area and I do feel more loose. So I’m trying to think of you like you and I always talk about you have this stacking effect, right you’ve got the anti inflammatory diet as the foundation, you’ve got the omegas coming in to hopefully help lubricate reduce inflammation. We’ve got the anti histamine anti mast cell course attend. We’ve got the ginger working on the Cox pathway, you’ve got the tumeric you’ve got the boswellia. I mean, that’s just really the synergistic thing here. And I’m not I haven’t taken a single aspirin. So I’m not actually in pain anymore. But like I said, if I sleep wrong, it might kind of flare me up. So I don’t think I’m fully out of the woods yet, but I think I’m 95% there. 

Dr. Justin Marchegiani: Correct. That’s good. So in general, we kind of have our Cox pathways right. Now, arachidonic acid can feed those pathways. So a lot of excess omega six junkie, refined omega six excess junkie animal products can definitely feed those pathways that sets the table like I mentioned gas in the kitchen right below spark and can take it off. And then we have our natural herbals like like ginger can help with Cox one. Fish Oil is actually For Cox two at high doses now if you do high doses of fish oil, you can increase what’s called lipid peroxidation. Because fish oil is a polyunsaturated fatty acid, it’s more unstable, right? It’s got a lot of these. It’s got more double bonds in it, right? omega three means three double bonds, the more double bonds that are there, the more unstable the fatty acid is to heat and things like that, the more let’s say it can be oxidized. So having extra vitamin C, or extra vitamin E on board when you’re taking extra fish oil, just to make sure you don’t have oxidation is great. And we already talked about things like systemic enzymes talked about, like, you know, curcumin, liposomal curcumin is better due to the absorption, or something with black pepper in it helps with absorption to already talked about things like Frankincense or boswellia is great, you could always do some white willow bark, which is kind of how aspirin is naturally made, right? aspirin works more on Cox one. So aspirin is going to be your other natural source. And you can do white willow bark, which is the natural form of aspirin, which is great. There are things like Tylenol, but Tylenol works more on the central nervous system perception, right? So it decreases the nervous systems, perception of pain. And then of course, at the extreme example, we have opiates, which block the pain receptors in the brain, the the opiate receptors in the brain, not the best thing because you’re just decreasing perception of pain. Obviously, the opiates are way more addictive, right. But we can block some of these natural pain perceptions with CBD oil. So CBD is another great way to reduce perception of pain. But we got to be careful of, you know, Tylenol, or things like opiates, you know, opiates due to their addictive qualities. And Tylenol actually chronically can reduce gluta file and you can just type in Tylenol and low glutathione level. So if you’re taking Tylenol longer term, you definitely want to take it with NAC and or some cloudify and just to be on the safe side. But in general, we want you to try to do more of the herbals and more of the natural stuff out of the gates because that really, really, really can help reduce inflammation. 

Evan Brand: Yeah, well said. Yeah, and the acetaminophen glutathione yeah, it’s a big problem. So that’s why I stayed away. So people listening, if you’re didn’t jump off a ladder like me, and you’ve got osteo arthritis or rheumatoid arthritis, or sports injury, or you’re just trying to heal up maybe post operation, these things we talked about today may be something to implement. And then obviously, working on all the other root causes too, because you are not just what you eat, you are what you digest from what you eat. So if you’re doing all these good nutrients, but you’ve got some type of malabsorption issue in the gut, you’ve got ridges on your fingernails, you’ve got thinning hair falling out here, you may need to look deeper at the gut and try to find some of these more root cause issues that led you to that amount of inflammation or slow recovery in the first place. So if you need to reach out, please do so. Our websites are That’s for Dr. J. He works worldwide via phone, FaceTime, Skype, zoom, whatever. And then me Evan Brand, So, please reach out if you need help. We love helping you guys. This is just a wonderful situation that we’re in to be able to help people across the globe get solutions to their health issues.

Dr. Justin Marchegiani: Absolutely. And one last thing to comment is people talk about what we know about cortisone and prednisone injections, right for chronic pain, right? This is a common thing. Well, what’s our natural cortisone? What’s our natural anti inflammatory? Well, our adrenals. So if you have weaker adrenal is going into this stuff, you may not be able to make good amounts of our natural kind of anti inflammatory hormones like cortisol or cortisone, right? This is important. Now I had a family friend come up to me recently, they had chronic pain issues. And it was asking me some questions about things. And they were telling me Oh, I just got a cortisone injection. It’s doing really great right now I said, Well, number one, that’s that’s a really big mistake. I said, you can do a cortisone injection only, only one if it’s really debilitating, and you need that to buy you time to fix the underlying issue. The problem with any injections of steroids is they start breaking down the tissue and the cartilage and the ligaments and the bone in the joint. And actually, over time, they’ll stop giving you cortisone injections in an area after two or three injections sometimes, so then now what now you’re kind of stuck. So the only way ever support a cortisone injection, is if that’s buying you time to do all the other stuff and the pain is so debilitating, you’re just doing that to buy you time because if you’re not figuring out and doing all the other stuff, while that quarter zones working, you’re just going to just repeat its pattern over again three to six months later. And that’s not a good situation. So ideally, you maximize the low hanging fruit, hopefully you won’t have to go to that. And then if you have to go to it, you at least use that time to do more of the right things regarding soft tissue chiropractic work anti inflammatory, there’s another device we we use here we’ll put a link below for the newbie device which is a bio electric device that I have and I use that helps reduce inflammation with special bio electric wavelengths. Electricity wise that reduce inflammation, improve blood flow, help improve the muscle integrity in that area. So the muscles take over the stress the joints and the ligaments and that’s cartilage would normally absorb right we want our we want our shocks to absorb The force not the sensitive material in the in the vehicle so to speak, right we have shocks for a reason. Think of shocks in your body as like muscles. Think of the sensitive tissue as ligaments and cartilage, right? Those are going to be more a vascular right poor blood flow the muscles more vascular. So what’s good let the vascular shocks absorb most of that issue most of the inflammation and for so I’ll put the link down below for that too. So you guys have that for references. Anything else, man? 

Evan Brand: Yeah, the sauna. The sauna has been helping me too. I love sitting in there. Yeah, that obviously warms me up to so I have the infrared heaters in the front and then the ceramic around the edges. So I do try to rotate make sure that the infrared does hit my back and it does help me quite a bit. So that’s also another beneficial thing. Epsom salt baths are very helpful potentially using a floatation tank, a float tank with just tons of Epsom salt and their magnesium and that’s that’s also another great strategy. So hope this helps people and take care yourself. Like I said, if you need to reach out please do or look forward to helping you soon. 

Dr. Justin Marchegiani: We’ll be right over recommended products down below so you guys can see that and take advantage of the things that we use clinically for our family, ourselves and our patients worldwide.


Audio Podcast:

Recommended product:  

Curcumin Supreme

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Immunity Boost Tips to Help You Stay Healthy Over the Holidays | Podcast #298

Your immune system likely needs a holiday boost, and you are the only one who can do it. (Things like stress, foods high in saturated fat, alcohol, and skipping exercise can all weaken this key part of the body that helps fight off infection and keep you healthy.) Let’s hear from Dr. J and Evan to help you put yourself at the top of your holiday checklist and give yourself this gift of health. 

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Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

2:28    Vitamins, Nutritional Mushrooms

11:31   Blended Formulas, Supreme, Monolaurin

18:00   Biofilms

21:07   Essential Oils, Nebulizers

22:49   Nebulizers

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Evan Brand: And here, this is a time of the year where hopefully everybody’s getting together and having a good time. And we had some questions about immunity and what people should be doing. 

Dr. Justin Marchegiani: Yeah, they’re all valid, valid questions. I mean, this is the time a year right, vitamin D level starts to drop. Usually, we got more viruses out there floating around all different kinds, we have obviously lower vitamin D as well, because the angle of the Sun is dropping a bit due to winter. And then obviously, more sugar consumption, more treats, more candy, more sweets, from Thanksgiving, and Christmas, etc. So all those things are going to have a major effect compromising the immune system, plus people get their end of the year deadlines with work. So a lot of emotional stress, buying gifts, all the family obligations. So all of these stressors summit and could have a major effect on compromising your immune system. So our goal today is kind of to talk about all these things and different strategies that you can work on.

Evan Brand: Yeah, you know, those old classic Christmas songs, they’ll say, this is the most wonderful time of the year. But in general, most people I would argue, are more stressed. And they’re not as happy this time of the year, which is kind of sad, it really should be a happy time. And so I think first I want to dive into the impact of stress and the immune system, if I may, and want to talk about the influence of stress, whether that’s related to sleep, blood, sugar, emotional, whatever, that is really going to impact a lot of things. But most importantly, it’s going to affect your immunity. And so we know, we’ve seen countless cases where people are going to go from a 40 Hour Workweek and they go 5060 hours, we work with a lot of attorneys, CEOs, we work with executives, we work with teachers, we work with real estate agents, and we always see there’s this kind of a, I call it like the hustle effect where someone will go go real hard, like you said, kind of the end of the quarter sales thing, you know, they really got to get their numbers, or we got to finish this before the semester ends if they’re like a college professor, and then all of a sudden they have a crash from it. Now, if we can kind of come in with some strategic adaptogenic herbs, those can be helpful for the immune system as well. So I think the easiest one, just right out of the gate is going to be Reishi or Reishi. Mushroom, I think that’s going to be your best adaptogen that I would argue has some good stress and blunting effects. But it’s going to be great for boosting up your natural killer cells, which are going to be really important for any type of illness that you may be exposed to.

Dr. Justin Marchegiani: 100%. So of course, like you kind of hit you kind of highlighted a couple things off the bat here, just all of the immune stress due to the holidays, all of the obligations, all of the food stressors. So I mean, of course, the first thing I think we can kind of look at is alright, don’t compromise on sleep, make sure you’re getting enough sleep. And then make sure your diet is at least reasonably well. And I kind of tell my patients, if you know you’re going to be eating a whole bunch of treats or some not so nice food, try to always find a good replacement, you know, try to find something that’s going to be more healthier on the on the sugar side on the dessert side on the treat side. So you have a healthier substitute, especially if you have kids, right? We know once your kids get sick, they tend to be like the little petri dish that carries viruses and bacteria throughout the family. Right. So you want to keep your kids healthy. So kids don’t know any different. Just try to choose a healthier cheat. So I’ll tell you what we’re doing for the holidays, I went to a local trophy, true food kitchen and we got some of their squash pies. And we get we’re getting them for some of the holiday dessert. So they’re going to be a healthier kind of paleo version, cassava type of cross lower sugar but clean ingredients. Now we also use a couple other pecan pie and pumpkin pies that are just really clean ingredients, very little added sugar. And then we try to make a lot of our sides are going to be paleo, right so good clean, heirloom, pasture fed Turkey, organic mashed potatoes, good quality kerrygold butter, like not too much on the carbohydrate side. And we know all that glucose, all that carbohydrate, right is going to convert to glucose in our bloodstream. And glucose tends to have a similar molecular structure as vitamin C so it can bind into that vitamin C receptor site and it can negatively impact our immune system can also abnormally affect cortisol. So if you can get your glucose levels and your glycaemia under control that has a huge impact on vitamin C and your immune system so first strategy is kind of look at the desserts in the in the treats that you’re going to have around for the family and just try to find a healthier substitute for all the core ones and try to look at it as you know 80-20 90-10 in regards to kind of you being on point versus you being off point.

Evan Brand: Yep, yep, good point and then beverages I mean, we do a lot of herbal teas I’m always just brewing some some tea so I think if you have somebody who’s not really entity or if you’re just not a tea person look at something like a hibiscus tea with a little bit of monkfruit or stevia I mean that’s delicious. You won’t know and your your your friends and family they’re not going to know if it’s not like a juice. I mean, some of the hibiscus blends I grew up I mean it almost tastes like juice. I mean the kids just absolutely love it. Even my 18 month old Drink hibiscus tea. So I think something like that would be smart, and just keeping you away from all the corn syrup. I mean, it’s crazy how, you know, you still look at the the table and it looks like we’re still in 1990 you’ll see the the coke and the Diet Coke and the Pepsi and the whatever it’s like, No, we don’t want that. That’s there’s definitely, definitely an impact on sleep, stress, blood sugar, sugar, it’s all connected. So it’s really easy to derail yourself, but it’s so easy to dial it in. So what I would be doing, I would be doing a gram a day of some reishi mushroom, I would be doing a gram a day of some quarter steps mushroom, which is going to be great for energy production, but also just as kind of an adrenal adaptogen. And then with some of the diet tweaks you’re mentioning, and going to bed, I mean, that’s the simple thing. Yeah, to be off to a good start. 

Dr. Justin Marchegiani: That’s, that’s a big one. So I mean, I just say get the food right, keep the glucose under control. The next thing on top of that is you know, low hanging fruit is going to be things like vitamin D, vitamin D, for dog, vitamin C, for cat, these are all going to be super helpful things. Vitamin D has a major effect on modulating the immune system, right th one th two it affects the T regulatory cells, which can modulate your immune response. Also, vitamin D produces this antibacterial peptide called cathelicidin. And that can have a awesome impact on bacteria that you’re exposed to. So vitamin D is great vitamin C, like we chatted about, it’s wonderful. You can always do things like glutathione. Or if you want to save a little money, some n acetylcysteine. And that can have an effect on glutathione is wonderful at modulating the immune system as well. Especially NAC is very helpful for mucus production and post nasal drip stuff. And which can help with a lot of cough stuff as well. So and acetyl, cysteine and glutathione is wonderful. I’m taking some reishi mushroom here, right now, Reishi has a couple of compounds in there, it’s got the one three Beta Glucan in there, it’s got the various polysaccharides, it’s got things in there called triterpenes. And trader beans actually deactivate virus replication. And so it’s very nice because it can one enhance your immune system, your th one immune system, which is kind of the natural killer cell immune response. But it can also decrease virus replication. And so a virus works by getting into your cells, and they replicate things like zinc, decreased virus replication, things like glutathione, decrease it, and acetylcysteine decreases it. So these are all powerful nutrients that you can use to Reishi, the terpenes decrease it. So if you can do things that naturally decrease that replication, it gives your immune system a huge advantage.

Evan Brand: Yeah, that’s wonderful. And then with the vitamin D, I believe you and I have access to like an at home professional finger spot prick blood test, where you could check and confirm your levels of vitamin D. However, in most cases, we’re going to be running comprehensive blood panels on people. So if you’re listening, and you’re like, well, I don’t really know where I’m at, or what I should be doing dosing wise. In general, fall, winter time, to anywhere up up to six, maybe 8000, I use of d3 Plus, we have professional formulas we’re using where they have a little bit of K one and K two added as well. And then you could just confirm after two to three months of supplementation with your blood you want to be I would say somewhere 60 to 80, I think is smart, but at least a minimum of 30. I can’t tell you how many people we’ve seen initially where their vitamin D is in the single digits or in the low 20s. That’s a very, very common spot to be with that. I mean, look at people, they don’t spend much time outside anymore. And they’re, they’re covering too much of their skin. And now as you mentioned, this time of the year, when we’re talking in late November, you’ve got the angle of the sun, where if you’re farther north than basically Atlanta, Georgia, it’s almost impossible to get any vitamin D, except for maybe a couple of hours in the middle of the day, you know, but once we get into the deep winter, just the angle of the sun, you just can’t do it unless you’re in like South Florida, basically, South Texas.

Dr. Justin Marchegiani: Exactly. Now, vitamin D kind of a good rule of thumb is you can take 1000 views per 25 pounds of body weight and then retest usually within one to two months. If you know you’re low out of the gates, I typically recommend doing whatever one 1000 iu per pound or 1000. I used for 25 pounds of body weight times two. So if you’re like 200 pounds, right, that’s going to be typically 8000 I use times two so like 16 to 20,000 I use for a month and then and then bring it back down to the general recommendation of like that five to 8000 right, you know, layer and again after that first month, you may want to retest that way you can kind of get your levels up fast tests, make sure you’re good. Make sure you’re not over 100 or so. Again, vitamin D is a fat soluble vitamin so it accumulates over time, but when you pull it out, it also drops slowly over time. It’s not like a B vitamin or vitamin C. That’s water soluble It’s a fat fighter Wednesday. So while the kind of it can increase pretty fast, but then takes a while to decrease it, so sometimes getting it up to 100 or so, and then kind of pulling back a lot, even if the level that you’re at may not be enough to keep it there, you may be at 100 or so in December, and then the time March hits, you’re like at 70. That’s cool, too, because then the springs coming back, and then you’re going to be getting more sunlight. So that works, too.

Evan Brand: Yeah, that’s good advice. And then vitamin C. I mean, it really depends on where you’re at with your bowels. I mean, we use a lot of different blends of vitamin C, which kind of helped move the bowels too. So generally, I’m going to be two to three grams a day, I don’t see any issue with that dosing, sometimes we’ll go a little higher. And sometimes we’re at a gram a day. So I think I’d say one to three grams, on average would be about right for for vitamin C, and we’re going to do a mixed ascorbate, if possible. So we’re trying to avoid using just straight ascorbic acid, we find that, especially just that by itself, it doesn’t do much, we really like to see some of the citrus bioflavonoids in there, the course attend the route. And those are the things we use. So if you go to, I don’t know, Walgreens or just generic store and get vitamin C, probably just ascorbic acid by itself, probably not going to absorb much. And so we’ve tested thousands of people via urine organic acids testing, and we always see low vitamin C, it’s a very, very common occurrence. And so I would argue, a mixed ascorbate, like a professional formula that we carry is going to be much, much better. Exactly. So you like the ascorbate. And that’s the one that’s reduced. Correct. I like to do the mixed one. So like a sodium ascorbate, magnesium ascorbate, calcium ascorbate. Those three together work awesome.

Dr. Justin Marchegiani: Yeah, like that. That makes a lot of sense. That’s cool. We talked about vitamin C, we talked about some medicinal mushrooms, I have a blend blended formula called immuno boost. And that is a really good one because that’s actually you know, Supreme, and that has some really, really good nutrients in there that are going to be amazingly helpful. And that’s going to have like akinesia in there to net akinesia, it’s going to have some astragulus, which are really good for modulating the immune system, they’ll have some mushrooms in there. So we’ll have some Reishi, it’ll have some pataky, it’ll have some cortiseps in there. Also some monolaurin monolaurin. Excellent, because that’s a very helpful at decreasing virus replication. monolaurin can kind of come in there and it can digest the virus envelope. And the virus envelope is like a cloaking device the virus uses to hide from the immune system. So as soon as the immune system can tag the virus, it’s easier for the body to now go after that virus and destroy it. And so by decreasing that virus envelope, its ability to hide it monolaurin can be used in a very helpful way to expose that to the immune system. 

Yeah, I love monolaurin. We both got animals. I hear my dog barking, I hear your cat meowing. It’s like the farm life over here, isn’t it? Yeah, no, totally. Absolutely. So we hit on the sleep, we hit the stress, we hit the mushrooms, we hit the vitamins. You know, I think just a good methylated multi is good. I manufacture one called True multi I believe you manufacture a professional multi as well. Just getting a lot of the bees, bees and Bravo are going to be important because with the stress of whether it’s just your day to day life, your work stress, the emotional stress, whatever is going on with you, you’re going to burn through your bees pretty quick. We’re going to measure those via urine. But your average person, if you’re just someone listening, you’re not actually running organic acids testing to confirm this, just trust us we’ve seen thousands of cases, I’ll tell you a B vitamins are going to burn up quick. So it’s okay to supplement those. And your pee may go highlighter yellow for a little bit. That doesn’t mean you’re wasting your money, you’re just going to pee out the excess and then your body’s going to get calibrated. And you should just have no relatively normal urine. It may always be a little more yellow with the bees. But that’s not an issue. And that, like I said, doesn’t mean you’re wasting your money.

Yes, 100%. So we talked about vitamin D, we talked about the Reishi. We talked about glutathione vitamin D as in dog, I talked about monolaurin and how that kind of helps digest and break down the viral envelope. Let’s talk about astragalus or akinesia or golden seal. These are wonderful herbs that have amazing immuno modulating effects. So I like astragalus as well. It can do a couple of things, they can decrease virus replication. Usually these herbs do kind of they have like two major mechanisms, they enhance the immune system, usually a combination of th one th two tends to support more th one but they also can help the th two side and where they make where they actually make antibodies. So you can help the natural killer side th one or you can help the antibody production side. Usually antibody production side comes in a little bit later in the game. So if you want to avoid getting sick, it’s going to make a bigger bigger difference if you’re if you’re enhancing the th one because that’s kind of the faster acting immune response. Now longer term supporting th two is very helpful because you can have what’s called cross reactive immunity. So your th one immune system may have seen previous viruses in the environment. And it can mobilize antibodies faster even though those antibodies may not already be there, you may be able to mobilize those antibodies faster because the th one immune system has seen similar viruses in the past. So you may get a faster mobilization of these different antibodies. And so yes, in my product is the amino supreme one and a couple of the ingredients, we have the akinesia in that one and the astragulus, which is wonderful. Also andrographis, very similar. Goldenseal, very similar monolaurin, we talked about monolaurin the different medicinal mushrooms, corticeps, shitake, mytaki, Reishi, these have effects on supporting the th one and also the triterpenes help deactivate the virus, right. So what does that mean? virus has to replicate to start creating symptoms, right. And if the virus cannot replicate, you deactivate the replication process. Now, not a big deal, your body can keep it under wraps. And then of course, things like zinc, are going to help with virus replication. So I’ll put a link down below to my product. Um, you know, Supreme, I know you have one similar to Evan, will make sure that’s down below. And these are things that we clinically use with our patients that work really, really, really well. 

Evan Brand: Yeah, you know, berberine is a good one, too. I mean, there’s a lot of papers on anti influence activity of berberine. And viral clip, reducing viral replication, using berberine. So for those listening, if you’re doing any kind of anti microbial protocol with us, a lot of times we’re using blends, like in particular one that I have called microbiome support. Number one, I use that a lot for gut infection, so any kind of bacterial overgrowth issues, but guess what, the cool thing about herbs, unlike drugs is you have, you’re killing multiple birds with the same stone. So we could be coming in with the berberine addressing the bacterial overgrowth, but then we’re also reducing viral replication. So I think that’s a great one berberine in isolation would be fine. But something like the microbiome support as a broad spectrum. You know, that’d be smart, too. And for your gut, I’ve got some dgl in that product. So that’s going to be giving you a little bit of gut healing, if you’re eating some stuff that you may be irritating your gut by, you know, that’d be a good insurance policy. And then what about enzymes? Should we hit on enzymes at all? 

Dr. Justin Marchegiani: Well, I mean, you can do systemic enzymes, which can be helpful for just kind of breaking down viral envelope as well or helping with stagnant you know, coagulation, right? If you have increased coagulation, a lot of clotting, poor blood flow. Enzymes can be helpful for that perspective. Also, maybe with biofilms right resistant bacteria have biofilms. What other kind of what were you thinking of em enzymes for in regards to supporting the immune system out? 

Evan Brand: Yeah, I was I was thinking like, there’s a couple that we use, like there’s [inaudible]. There’s lumbered open- 

Dr. Justin Marchegiani: -about it from a biofilm perspective, or quagga bility thing? How are you thinking about it? 

Evan Brand: Yeah, good question. Probably the biofilm piece because I’ve had a lot of people with resistant infections where will come in with a biofilm support, and then that kind of gets them over the hump. So Lately, I’ve been using a lot of different ones. Beyond balance has done a great job making some particular biofilm products, you have to use us a professional to order it for you. But we’ve done we’ve done good with those. And then there are some other professional companies I’ve been personally experimenting with some lambro kinase. And that’s a much much stronger than something like a sarapeptidase and I’ve noticed a big increase in blood flow, like my hands are much much warmer using lambro kinase. So I know it’s doing something from a circulatory perspective. And I would argue that when you’re taking all these herbs and mushrooms, if you have good blood flow, good circulation, that’s going to deliver the nutrients everywhere. 

Dr. Justin Marchegiani: That’s the key. So when you get really inflamed, usually there’s a lot of poor coagulation, a lot of poor circulation, there’s increased coagulation, right? coagulation, when the platelets kind of stick together and they kind of clot and you get more fibrinogen hanging out right then more fibrin or fibrinogen, because he goes fibrinogen to fibrin, so fibrin, or like the clot, so to speak. The more fibrinogen fibrin you have the more clots you have the decreased blood flow you’re going to have. So a hallmark of inflammation is just a lot more sticky cells. And so if you can make those cells a lot more smooth and less sticky, you do that with a good anti inflammatory paleo template. You do that by keeping your blood sugar down. You do that by keeping inflammation down from grains and other inflammatory foods, hydrating adequate good fats like fish oil, right. Evan mentioned the enzymes also help also ginger ginger is amazing. Ginger actually has antiviral qualities. Go into PubMed, type in ginger or zinjibber, which is I think the technical term Zinjibber, and you’ll see all kinds of studies on inflammation reduction, you’ll see viral particle replication or viral particle adhesion, part of how viruses everywhere they have to stick to a cell receptor site to stick to it. And if that’s removed, Iris can’t stick to it as well right Were you able to flush it off with ginger are good antimicrobials are biofilms. All that can really, really help the virus from causing problems it can really prevent it from causing problems so gingers great good anti viral, helps decrease viruses from sticking to the receptor sites also is very anti inflammatory, supports good healthy digestion and motility as well and can really help with irritation in the throat so like coughing and things like that. Ginger has a natural Tustin quality to it right custom meaning it kind of helps with the coughing and so does you know, decreasing the mucus with like a good n acetylcysteine. And some good really good sinus flushes with xylitol and bicarb. And minerals can also decrease any bacteria or fungus junk up in the nose or even going down the throat via a post nasal drip issue. 

Evan Brand: Love it. Love it. Yeah, gingers amazing. I mean, we talked about it. You see it at the grocery store. You look at it, you’re like, is ginger really that special? Yeah, it really is. I actually had a double bag of ginger yesterday with a little bit of raw honey and it was absolutely just so delicious. So therapeutic.

Dr. Justin Marchegiani: Excellent. Well, anything else you wanted to highlight off the bat, I mean, a couple things you can do. There’s some good essential oils that are out there that you can kind of drip into your water and just kind of get a homeopathic dose in your water throughout the day. It’s helpful. I know there’s a couple brands doterra has one called ’On Guard’. And then I think Young Living has one called ‘Thieves’. You know the common theme and a lot of these usually some kind of clove or cinnamon or some kind of like an orange peel s kind of thing. And these are very antimicrobial, very immune supporting and you can always kind of put a low dose in if you have a little throat issue going on. You can always kind of gargle with it too. Or if you’re doing some oil pulling, you know, put a couple of drops in the oil in your mouth and kind of swish that around and give it five or 10 minutes and they can kind of hit the back of your throat and clean out any nasty bacteria or biofilms that are hanging way back in your throat can be very helpful. Just make sure you spit it out afterwards.

Evan Brand: I think diffusing would be smart too, right, why not? You could defuse put some of the oils into the air Just be aware of your pets. I don’t remember what particular oils that were but I did have a client who was getting super into the oils and she was diffusing something and her dog got super lethargic had to take the dog to the emergency vet. I can’t remember so just do a little research essential oil dogs diffuser, there was a couple of stories about you know particular one so don’t go too crazy pumping your whole house full of it and making your dog pass out or something like that.

Dr. Justin Marchegiani: Correct. Yeah, that makes sense. That’s smart. The only other thing I would say besides the essential oil I think we Oh, I think we could also talk about diffuse including ion there are some really good reduced kind of soluble glutathione compounds out there. I’ve one called by third naturals is really good. I’ll put a link down below if you guys want to see I think you have a link as well to it. 

Evan Brand: You mean, nebulize? You said diffuse you mean? nebulize? 

Dr. Justin Marchegiani: Oh, yeah, I meant Yeah, well, kind of the same thing. But yeah, in general, we basically a diffuser is kind of for the systemic environment. a nebulizer is something like this, that you put in devices device like this, don’t you love that is that i mean is that nebulizer not the best one I’m telling ya, man, it’s great. I gotta clean I gotta clean it out a little bit. But you have the battery here you have the facemask here, you just connect it in like this. Yeah, the one he’s showing for people listening on audio, this is a one by Philips, it’s called inspire in a spire. And then you basically just take the five milliliters of a salient solution, you put right in the top here, and you add your 200 milligram glutathione reduced. And it’s it’s you can’t do it for any glow to find on the one that we’re talking about. It’s by a company called Therm Naturals, we’ll put the link below. And that is a glutathione that’s reduced, that’s mixed with sodium bicarb. So then when you add the saline solution to it, it actually becomes soluble. It’s just total it diffuses into the water 100%. And then you close the cap attached to the battery pack. And then you can do a five minute session or so breathing right in. And that’s helpful. If you have active lung issues, it may not be necessary. If you are already are in good shape, you may just be able to take some oral glutathione or oral NAC. But if you start to have active issues, it can be helpful because you can really increase the saturation right into the lung area to the alveoli. And right into that respiratory tree. 

Evan Brand: Yeah, I’ve used it with several clients who’ve had lung issues. And it’s been it’s been great COPD and other issues. It’s been wonderful. So it’s a great, great tool to have, like you said, you probably don’t need it if you’re super healthy. But if you got some going on, you may want that out.

Dr. Justin Marchegiani: Yeah, it’s active. And you may want to even look at it using it for a really good silver as well. You could do a silver maybe 10 pm or less on there. It’s very controversial. So kind of do a little research on that. I don’t just recommend that because a lot of conventional doctors don’t like it. But if you’re doing a silver that’s very, very small. It can be helpful if you have an active viral infection in the lungs. But But do your homework on that first, because you don’t want to be nebulizing silver that is a large molecule sighs we want to make sure it can move to the sell adequately.

Evan Brand: Yep. Yep. Good advice.

Dr. Justin Marchegiani: Well, you triend nebulizing silver by the way? 

Evan Brand: I’ve done it, I haven’t, I wouldn’t say I would, I would notice a ton from it, you know, it’s not one of those things where it’s like, whoa, I feel incredible. But I’ve done it, I’ve mixed it. I’ve done the glutathione on silver combo, you know, but I wasn’t in too bad of shape. So I, you know, I can’t say that silver was necessarily a magic remedy for me or not, but I have done the silver up the nose. And I do believe that has helped as well for some of the sinus colonization that can happen.

Dr. Justin Marchegiani: You can do silver up the nose, you can also do silver orally, you know, any of the side effects that you see about silver, like the argyria turning blue, that has to do with very large silver molecules and usually kind of a homebrew. If you’re dealing with a high quality silver brand made by like, you know, a tier one supplement company like the one that I make in my GI33 or like a sovereign silver or like some kind of a silver soul or some kind of a nano silver. That particular is very, very small, and your body’s gonna have no problem excluding it. It’s a very, very large silver molecules that are going to be problematic.

Evan Brand: Yep. Yep. Well said. 

Dr. Justin Marchegiani: Anything else Evan? 

Evan Brand: I don’t think so. If people need help clinically, please reach out. We’re available worldwide if you want to get a hold of Dr. J., worldwide consult. So even if you just need a call, hey, I need help. I’m concerned I need help to boost myself up. What do I do? You know, we’re here for that. But we love helping people get to the bottom of their issues, using functional lab testing to find and fix the root causes of your issue. So rather than coming in and doing the spot treatment, have a little bit of this a little bit of that. The reality is, hey, here’s what’s going on under the hood, this is what’s putting you at a disadvantage. So we’re going to help fix you. So And for me, Evan Brand, and we’ll be back. So stay tuned.

Dr. Justin Marchegiani: Put your comments down below everyone. We really appreciate it comments below, give us a like give us a thumbs up. And if you want to dive in deeper, we’ll put the links for you guys to make it accessible. Hope you guys have an amazing holiday season coming up. We’ll be in touch. Take care y’all. Bye now. 

Evan Brand: Take care.


Audio Podcast:

How to Treat Gut Infections: Antibiotics or Natural Herbs?

By Dr. Justin Marchegiani

Gut infections are common, and they can prohibit healing and cause a leaky gut. They must be treated to keep the body healthy, but are antibiotics the right choice for you? For some serious infections, antibiotics might be a good choice, but there are deleterious side effects.

herbal antibiotics

Let’s explore why antibiotics have side effects; why antimicrobial, or natural, medicines may be a better choice. And also, what the benefits are of natural medicines.

Antibiotics Pros & Cons

Antibiotics are one of the true miracles of the twentieth century. The invention of penicillin and other antibiotics over the last 50-75 years have saved thousands if not millions of lives!

We live in a world today where antibiotics are handed out like candy, and as a result our gut biome and our health are finally paying for it. Most conventionally trained physicians are still not recommending a round of probiotics after an antibiotic treatment. In my professional opinion, this is an absolute must if antibiotics are ever to be used.

There is a phenomenon known as antibiotics resistance where we are creating superbugs from excessive antibiotic use. I saw a patient just last week who over a 10-year period was given over 100 prescriptions!

This excess antibiotic use causes rebound overgrowth in the digestive tract, essentially causing the bad or sometimes pathogenic bacteria to proliferate. As a result, it will take up most of the space in our GI tract.

antibiotic resistance

If you use the garden analogy for our gut bacteria, everyone knows it takes virtually no effort for weeds to grow, yet, it takes good eating habits, stress reduction, and sometimes supplements to keep the good bacteria predominating. In the garden analogy, the healthy plants or vegetables growing.

When to take Antibiotics?

The bad bacteria in our gut can produce toxins and make it harder for us to absorb nutrients from food. In acute serious infections, antibiotics may be the right choice. With these chronic everyday situations, herbal medicines have a longer and safer track record and tend to be more selective to the bad bugs without causing as many side effects.

I was in a serious situation this last summer with a hand infection from a cat scratch and I was very close to using an antibiotic to treat the infection. I actually had the prescription in my possession, yet after 3 days of natural herbs, the infection resolved. If the infection hadn’t started resolving so soon, I would have had no hesitation to use the prescribed antibiotic.

What Are Efflux Pumps?

Bacteria or infections have a phenomenon known as efflux pumps. The antibiotic enters the cell, where it is metabolized. The efflux pumps then force the antibiotic out of the cell and into the extracellular space or back into the gut.

Imagine you’re in a canoe on a river, and the canoe has a hole in it. The canoe starts taking in water. Your natural response would be to grab a bucket and start bailing water from the canoe.

Efflux pumps are very similar to the bucket. The bucket takes the water that shouldn’t be in the canoe and bails it back into the river.

The same thing happens with the bacteria. That bacteria wants to thrive, and it knows the antibiotic isn’t good for it, so it takes the antibiotic. Just like you’d bail water from your canoe, the bacterial will shoot it’s way back into the intestinal track where it thinks it belongs.

efflux pumps

Our goal, however, is to kill the bacteria, so we must inhibit the efflux pumps. If we inhibit the efflux pumps, the bacteria will retain the drug or the antimicrobial, which will procure its demise. If the canoe is analogous to the bacteria, we want the canoe to take on water faster. So knocking out the person with the bucket (the analogous efflux pump) is the goal.

Do you think you have an infection, click here!

How Can We Block the Efflux Pump?

When we create protocols to knock out these infections, how to block the efflux pump is the question that is first and foremost in mind. There is a family of herbs called berberines, and it includes the following:

• Goldenseal
• Oregon grape
• Barberry

These herbs have efflux-inhibiting properties. They have been used in cancer medications, infection-treatment plans, and other treatments. They actually block the function of the efflux pumps.

If you’re going to use an antibiotic, at least use it with a gram of goldenseal to block the efflux pump. This will prevent the bacteria from shooting the antibiotic back out into the extracellular space or the gut.

However, a better choice, which may give a far superior result, could be to take a combination of berberines and other herbs. This is especially effective if you are in relatively good health and making good dietary changes. This healthier lifestyle will boost the immune system, giving you a better chance of responding to the herbs.


What Are Natural Ways to Address Gut Infections?

  •  Local killer: Goldenseal is one local killer that will target the area of the infection.
  •  Systemic killer: Artemisia or wormwood are systemic killers that will get in the blood and target the whole system.
  • Infection-specific killer: Herbal cocktails are created specifically to fight a certain infection. If you have a virus, we may use silver; If you have a Lyme disease coinfection, we may use neem or noni; And if you have a gut-bacteria issue, we may use oil of oregano.

There is an excellent synergistic effect when combining local and systemic killers—wormwood and Artemisia combined with goldenseal. The goldenseal makes the Artemisia stronger.

The Viscous Cycle of Infections:

Most people with a chronic unaddressed infection are kept trapped in a viscous cycle of a weakened immune system, nutrient malabsorption, and a leaky gut.

Our body needs nutrients to run its energy systems, and we derive those nutrients primarily from food. With a chronic leaky gut due to infections, we are assured to develop food allergens to even so-called healthy foods, like broccoli and beef. Thus, our diet becomes more restrictive as the root cause to many of these gut issues gets commonly missed.

With the additional stress to our digestive system, we also lose the ability to make adequate levels of enzymes and HCL. These compounds help break our food down, but they also help kill potential foreign invaders in our food, like bacteria and parasites.

As you can see, it’s common for people, over the years, to collect their gut infections like souvenirs on their mantle. The more gut bugs or infections you have, typically the longer it takes to recover.

If you want to break the viscous cycle of gut infections, click here!

gut infections cycle


Efflux pumps are the real problem, and that’s why a lot of antibiotics have side effects. The protocol for most antibiotics is only about 10–14 days. With a natural antimicrobial program, the protocol can be 60–90 days, allowing us to slowly break down the whole efflux pump system.

Natural programs include using specific herbs, like the goldenseal, and utilizing the synergistic effect of stacking local, systemic, and infection-specific herbs.

Use Mother Nature’s natural herbs first and foremost. Antibiotics can be beneficial when used in combination with the appropriate natural herbs, but antibiotics should be the last-resort approach.

If you have a gut infection, tough-to-remove parasite, H.pylori infection, or viral infection, these are common blocks that keep you from healing and cause a leaky gut. If you need more help to eliminate these gut infections, click here.

The entire contents of this website are based upon the opinions of Dr. Justin Marchegiani unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Justin and his community. Dr. Justin encourages you to make your own health care decisions based upon your research and in partnership with a qualified healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Dr. Marchegiani’s products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using any products.