Mood Imbalances and their Root Causes | Podcast #250

Depression, being the #1 cause of disability in the US, has tons of other mood issues that come along with it. Some psychiatrists are not telling what are the things that caused us mood issues,and what should we do to lessen it.

For this podcast, Dr. Justin and Evan Brand talks about root causes to mood issues.  Also, learn through this podcast the importance of blood sugar maintenance, sleep, diet, and a lot more.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover: 

01:15 Moods and Diet

03:40 Blood Sugar

09:00 Sleep

12:20 Chemicals in Food

14:40 Progesterone and Estrogen

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Evan Brand: I’m doing very well. This is an exciting topic because depression is the number one leading cause of disability in the US and there’s a ton of other mood issues that come along with depression and your psychiatrist is not telling you that you need to detox heavy metals and get infections out of your gut and stop eating pesticides and all the other things that are causing a mood issues. They just give you a drug to treat it and give you a Band-Aid which has save lives but it’s not the root cause so we always love root cause. 

Dr. Justin Marchegiani: 100% So let’s talk about some root cause foundational mood stuff first and we kind of have the Nuance nitty-gritty stuff and then we have the foundational stuff. So the first thing is just your diet, right? We need a nutrient dense anti-inflammatory low toxin dietary template and I I like to talk about diets me template. It provides a lot more flexibility and then we have a framework premise and why we recommend the things that we recommend part of it is foods that are evolutionarily appropriate Foods. We had enough time to adapt to eat, food that are going to be low in toxins, whether it’s anti-nutrients are oxalates are five dates or natural plant Oxalis plants have claws and feet to run and Fun Run and fight so they have berries toxins, right? So we want to make sure were using cooking methods and avoiding toxic plants, especially the more got issues we have and that anti-inflammatory, right? We know foods have the ability to move us to an anti-inflammatory environment good healthy, omega-3 fatty acids good healthy saturated fats of the more process refined omega-6 that are more fragile and they can move it move us more in that Pro in from inflammatory State and then of course the nutrient density foods are going to be super nutrient dense B vitamins minerals. Obviously the food quality is now a big deal because you can have the same kind of meat on on your plate. Looks totally different under a microscope because of the hormones because of the feeding practices cuz the medications and the and the drugs given to the animal while they were having their life and growing so to speak. So we have to look at nutrient density anti-inflammatory status and hormones and toxins are the big things off the bat. 

Evan Brand: I’m glad you about this before but we could just bring it up briefly which studies done on prisoners and when they were giving Omega-3 supplements basically fish oil supplements, they had less violence and less just crazy behavior overall and there’s been some like Psychiatry studies looking at just overall like homicidal rage and suicidal thoughts and those things in there directly correlated with a deficiency of omega-3. Fatty acids 

Dr. Justin Marchegiani: Omega-3 is really important. Also blood sugar stability. There’s also data on the fact that’s Information I should say. Are you able to see me hear the screen? 

Evan Brand: Yeah, I see you perfectly.

Dr. Justin Marchegiani: Good excellence. All right, so there’s information showing that. Mood issues anxiety and depression is a result of inflammation in the brain. And we also know that anytime low blood sugar environment can happen right refined carbohydrates blood sugar Spike followed by a drop that’s called reactive hypoglycemia. Those kind of those kind of situations are going to create mood issues and this data on the fact that a lot of violent crimes are committed in a hypoglycemic environment and some of the data on that is because of the fact that low blood sugar and are making shutdown activation of the frontal cortex in the frontal cortex is the part of the brain that’s going to predict the outcome of an action so it can say Hey, you know that person that just pissed you off. I want to go hit him or go call him out. And then that frontal cortex has that like 20 milliseconds of hey, you know, if you do that you may get arrested and it can dampen the impulse so to speak so the more you have good activation of that frontal cortex through reducing inflammation. And then also maintaining good blood sugar and part of that as we become more fat burners and that fat burning environment put logs on our metabolic fire was future blood sugar from going up and down and then avoiding a lot of a refined carbohydrate which tends to make our blood sugar go up and down as well. 

Evan Brand: Well, this is part of the reason people make bad decisions when they go out to a bar into a club and they drink alcohol and go home with somebody that they don’t want to partial partially due to what is alcohol. I mean, it’s basically correct liquid. It’s basically liquid sugar. It’s going to crank up the blood sugar but it’s also going to crank up serotonin and then the serotonin is going to just flat line and when you run out of Serotonin, you can’t make decisions that are smart. And so if you are somebody who is struggling with mood issues alcohol needs to be out of the picture completely for multiple reasons that we just met-

Dr. Justin Marchegiani: Blood sugar or I should alcohol actually lowers your blood sugar can create a hypoglycemic and where I might just go take a for instance a shot of vodka and just test your blood sugar your blood sugar. Drop restaurants do this on purpose because they know if they can get you some refined carbohydrates and pretzels and some bread and then they can get you some alcohol pretty fast. They’re going to cause a reactive hypoglycemia environments and you’re going to be ordering more food and getting more carbohydrates may be ordering a bigger desert whether or not they understand the biochemistry of it all they understand that if they do these kind of things in the beginning of the meal they can create a larger bill for you at the end of the meal.

Evan Brand: Should have clarified like margaritas and things that have like agave syrup and all the sugary stuff mixed with the alcohol. That’s when your blood sugar is going to go crazy, but I haven’t tested the Vodka by itself. That would be cool to see on a glucose monitor. 

Dr. Justin Marchegiani: Exactly yup 100% you can really create some significant significant issues of significant stressor 100%. 

Evan Brand: So we could spend time and talk about this isn’t for today. But I mean, there’s like a traumas for example, you know any trauma that’s left over in your body, you know physical mental abuse or anything like that yet. You must address promise. I don’t want somebody listening and thinking if they just perfect their diet and get rid of alcohol. Their mood issues will go way there could be super deep traumatic issues that need to be addressed but no we were trying to focus on more like the biochemistry aspect the blood sugar affect adrenals hormones thyroid got those things. 

Dr. Justin Marchegiani: 100% Yeah. I totally totally get that for sure. So in general we have the inflammation components to so of course gluten to be a big one there the main mechanism how gluten is in a create more mood issue is going to be through inflammation and it can create gut permeability and that gut permeability can allow various inflammatory cytokines and Undigested food particles to get in the bloodstream that can create more of an inflammatory response and then create leaky brain as well. And then a lot of these inflammatory compounds whether it’s lipopolysaccharides or just inflammatory foods that are unprocessed that you have that immune response these particular can get into the brain but through the astrocytes which of the blood-brain barrier and then that can activate our glial cells in our brain and that can create more cognitive issues more information in the brain and some of the newer families of antidepressants that are coming out very soon. These medications are actually working more on inflammation in the brain problem is like any medication is going to be at have inherent side effects just because of the fact that Any medication does when you block and inhibit various enzymatic Pathways other things happen as a result, like the old vioxx days with these cox-2 inhibitor medications the cox-2 enzyme the cyclooxygenase to enzyme that was being blocked by some of these medications like vioxx. Well, those enzymes also have beneficial effects on recovering liver heart and gut tissue to then you had a lot more stroke and cardiovascular incidences. When you were on this medication. Do you know they worked at enzyme and other important roles outside of just blocking paint. 

Evan Brand: Where they pulled from the shelves. I mean, that’s like long gone, isn’t it? Maybe I should look it up. 

Dr. Justin Marchegiani: Yeah that was pulled like 10 years ago. I make more cat a massive lawsuit around that I think it was on record of killing 60,000 people. Yeah. Yeah. I know really sad but we are going to do you know?

Evan Brand: All right. So let’s talk about the Sleep aspect like for example 3rd shift workers much much higher incidence it personally when you’re working a third shift. You’re messing up your circadian rhythm your serotonin in your dopamine your melatonin your cortisol all these hormones and neurotransmitters that can act as both neurotransmitters and hormones. They all have a circadian rhythm. And if you’re not going to bed with the sun and getting up with the sun, you’re probably not going to be optimally happy now. There may be a few people listening. So I work 3rd Shift for 20 years and Im as happy as a lark. Okay, Mike, maybe you’re unique but as a general human rule going against the sun is not going to result in Good Moods. It’s that simple.

Dr. Justin Marchegiani: Yep, 100% shiftworks a big one. We know that I can definitely Cradle by The Moody she’s partly because we are hardwired to kind of be on a natural circadian rhythm Right light stimulates cortisol cortisol stimulates, you know alertness and and being awake and then that cortisol drop throughout the day and a Miralax at night and darkness stimulates melatonin antioxidant information helps you recover. So yeah, that’s a really important step into this. Equation for sure. So they sleep component, the food the nutrient density component think it’s really big. Lets go to the next low hanging fruit– digestion. Okay, great. Were eating a really good diet. But now we got to actually break down those nutrients those nutrients so we gotta make sure what you and our food up. Well, we got to make sure we have enough acid and enzymes to break down those amino acids. Those fatty acids those cholesterol compounds cuz they are building blocks for a brain is cholesterol and saturated fats are hormones are building blocks from cholesterol as well. And then our brain amino brain chemicals. They’re all going to come from amino acids, which come from protein. So all of our brain chemicals norepinephrine dopamine Gaba serotonin serotonin than Converse the Melatonin which is our sleep hormone and our antioxidant for the brain, they all come from protein. So we really have poor digestion and their studies actually on H. Pylori for instance cant create mood issues. And what’s the major mechanism? My opinion, the mechanism is the fact that you have poor digestion you have less stomach acid. You have less breakdown of these important building blocks and then hes building blocks can be used to make these healthy brain chemicals that allow you to feel good sleep good and deal with stress. 

Evan Brand: Yeah. I agree. I was depressed when I had h-pylori could attest that my mood was not good and I lost a lot of muscle too, I mean you looked at me and you told me Evan man. I remember seeing a picture of you you had some muscles what happened to you. I was so skinny. Luckily. I’ve regained a lot of that muscle back but mood issues are definitely related to gut infections and I just want to talk about kids for a minute because a lot of parents blame their children or just being kids and that’s why they have a bad mood. I’ll tell you as a father of two mood issues are totally related to what’s going on with your kids diet as well and your kids got so if you send your kid to school with crackers and goldfish and other garbage that’s going to be inflammatory. But also it’s going to affect your blood sugar and they’re not having good protein with their lunch. It’s no wonder they crash. I have bad moods and then they are getting in trouble in school in the teachers calling you saying hey, you know Johnny hit another student today. What would have happened if his blood sugar was well regulated and go ahead. 

Dr. Justin Marchegiani: Yeah. I saw my son a picture of him. it’s snack time last week. It was really funny. All the kids are there had their lunch box is open and you could see he had like some green apples that were cut off. He had this like grass-fed organic, like beef jerky. They’re just really easy and Ill kind of cut off and he had I think some little bit of almond butter is a hit a really nice snack and he has seen a lot of the other kids. You see the Goldfish. You see a lot of sugary drinks. I’m like oh man, and these kids are just really getting their blood sugar on a roller coaster ride, and they’re not going to be as good I mean, don’t get me wrong nutritions not going to make your one or two year-old a three-year-old who is developing be a perfect angel but it’s going to significantly improve things and make it much much better and it’s in a provide the building blocks. They need one to heal in to grow their nervous system and connect all these synapses in the brain. All these neural connections from all these new skills that there that they are using but two are keeping a lot of the inflammatory dies and chemicals and Foods out that could make things even worse as well. 

Evan Brand: There’s been countless studies on the artificial colors and flavorings increasing the risk of ADD and ADHD. And a lot of these behavioral cognitive issues that are deemed as common so the teachers, you know, well just recommend that the parents speak with the doctor in the doctor puts the kid on Ritalin and that calms the kid down but that’s not the root cause he there’s a root cause of that and this is not hey, you know, Justin and I are awesome in our kids are better than you but I’m just telling you I’ve seen it my daughter hanging out a plate at a playground versus other kids where other kids in the same age group are having emotional breakdowns and they’re crying and rolling on the floor and screaming and just acting out like not how you think a kid would act out just not in control. Where is my daughter would be controlled or emotions would be controlled. Does she still have outburst and cry? Over silly Small Things. Yes, totally. But she’s three years old at the time of this recording. So I’m just saying that as a general rule, but also the chemicals to write when Im just talkin food. Were talkin that you and I both are you’re giving your son detoxification support. I give my daughter detoxification support. We’ve given both of our kids herbs to help treat gut infections and bacterial and things like that in the gut too. So maybe if the diet is dialed in but you’re not seeing any progress Improvement this applies for adults, but also children since were on the subject run a stool test on your 3 4 5 6 10 year old 15 year old kid and you may find gut infections like the H pylori just to mention as another root cause of the mood issue. 

Dr. Justin Marchegiani: Exactly plus it’s probably incidences where maybe some not-so-great food or more refined processed food slipped in with your child at all. And then you probably saw an outburst or behavioral issue, you know, we had an incident. I think on a birthday. We gave him a little bit of gluten-free cake and there’s a little bit of a crash afterwards we could see that in this by observations from you. So it’s all wrong with it. Right now. We definitely want to provide the hormone environment where it allows our kids to grow in NBA Staples possible think it’s really really important. We hit the the food component the digestion component. Let’s talk about four months. So obviously blood sugar has a major effect on our hormones the more I blood sugar goes up and down the more cortisol and adrenaline to get call to the rescue to to bar for that out to the mortgage Reno stress gets put on our body in archery know our stress handling system and the adrenals are a part of the hormonal system is connected with the sympathetic nervous system. So the sympathetic nervous system is the part of the nervous system that deals with fight-or-flight stress running fighting, fleeing confronting and that part of the nervous system the more it gets turned on or flare the more adrenaline and cortisol and stress hormones that are catabolic the break tissue down or going to be secreted and the adrenals also produce a significant amount of sex hormone precursor. So the more we’re stressed and dealing with the catabolic stress side last week and allocate resources to the anabolic repair and Recovery parasympathetic size. And then it makes it harder for us to recover put on muscle feel good turnover on neurotransmitters and just be able to deal with and adapt to stress. So there is that on one side and the adrenals affect the kind of men and women relatively equally but then women have their hormonal side from the ovaries that cycle throughout the month and that part of the Cascades a little bit more unique because cortisol, which is that major stress hormone that we talked about can also be made from progesterone. And so the more we are stressed, the more we can pull from the progesterone. I was thinking create more estrogen dominance so are relative ratio of progesterone estrogen which is typically 20 to 25 to 1 on average for progesterone Dash inserts asked you and this condition called estrogen dominance starts to occur with a percent of that returns coming up and this can create more mood issues more PMS kind of issues breast tenderness cramping back pain in the mood components of they want irritability anxiety depression. All those symptoms can happen as a result of that. So the more we can take away that up and down with our cortisol in the movie that takes out of that the less estrogen dominance will kick in.

Evan Brand: I just want to point out one key Point you’re speaking about ratios a lot of women come to us and say I’ve got so much estrogen. I’m so estrogen dominant know he’s not saying that you have tons of estrogen you saying in relationship to your progesterone. So it’s not that the estrogen is literally overwhelming and you have more estrogen than progesterone. that’s not what’s happening. Correct, correct? 

Dr. Justin Marchegiani: And it could be that your estrogen is actually really really high. Im seeing with a lot of my female patients is progesterone is low really low acids also low, but the ratio is still skewed. So Im seeing it like if you are as progesterone, right and he is estrogen what’s happening. Both are low, but progesterone is even lower. So it’s like that.

Evan Brand: Are you saying estrogen overwhelmed progesterone or would that be like an extreme case?

Dr. Justin Marchegiani: That being extreme case and almost all the time with cases like that. There may be an exhausting is pit Ashton being taken right? You’re definitely would see on the birth control pill side. You may not see it come back like that because a lot of egestion metabolites me to come back on the test cuz youre not, you know the actual the actual estradiol or estradiol hormone. They’re like the analog that it’s a metabolite that has still in that shouldn’t affect but it’s not coming back in the lab. So we just know the fact that if these levels are that high cuz you’re taking it then the warm out there going to be Might as well.

Evan Brand: OK make sense would be a mechanism to cuz if you had like yes High B6 recirculating all those hormones hormones would just make it works. Right if your recirculating hormones.

Dr. Justin Marchegiani: correct Plastics that I have seen no estrogen kind of facts whether [inaudible] egg. And then of course, you’re going to have hormones in the states right to give it a lot of estrogen type of hormones to make them fatter and kind of woke up. So to speak to the farmers can make more money on the slaughter there is that too. So that’s why you have to mitigate the toxins in the hormones and all the food and then you have to look at detoxification pathway. So well run on the docks tested a little gas gauge in the bottom left-hand corner of stop H3. it’s called the two methoxy hydroxy acid metabolites panel, or I should say reading and it’s a little gas gauge you want to at least in the middle, but you’ll see a lot of decreased methylation so it’s way to the left and that’s a sign that were not metabolizing are Estrogen. 

Evan Brand: Yeah, that’s important. So you have to address hormones and were not saying hey, you just go on thyroid medication. Like that’s not you know, this is a whole system here adrenals are connected to your thyroid thyroids connects. The brains involved. You mentioned the sympathetic nervous system. So if you’re somebody whos working 70 hours a week or not taking days off in your nervous system is so revved up. You can eat a paleo-diet and still have mood issues. 

Dr. Justin Marchegiani: Correct. Yep. that’s very possible. So we have those kind of hormone issue is and of course any women listening to it mood maybe one component of that. It could be other things as well could be the energy you could be back pain and cramping breast tenderness fluid retention. It could be all the above. 

Evan Brand: We should talk about toxicity and liver and chemicals and metals and stuff for a minute. But why don’t we just briefly mention autoimmunity and the role that I could play in hormone. So if you’re someone who has autoimmune thyroid, isn’t it possible that if you’re going from hypo to hyperthyroid, you may have some mood issues associated with that autoimmune attack or some day is the immune system is bang bang and then some days he knew system is not. 

Dr. Justin Marchegiani: So we look at hormones. it’s either ATM or ATF and it’s not you know, the ATM where you get money or the Alcohol Tobacco and Firearms government agency ATM is Adrenals Thyroid Male Hormones, ATF is Adrenal Thyroid Female Hormones. So we already talked about the adrenal and the female and the adrenal and the mail. Yes the same mechanism are as we complete DHEA and we kind of lets just say deplete our sex hormone precursor from the adrenals testosterone can also drop and then testosterone can have a significant mood depleting fact as well. So same on the men the little bit less has less pronounced because women have a hormone cycle that that rhythms up and down throughout the cycle or manner kind of like a flat kind of Foghorn. So to speak there isn’t quite as much rhythmic activity. Therefore it’s harder to knock that off so to speak but now with the thyroid issues women are going to be five times more prone to But men still listen because if you have symptoms, we definitely want to rule out the thyroid like you said just having low levels of thyroid hormone can create anxiety for sure and also having high levels can also create anxiety and irritability and also having Hashimoto autoimmune flares which would eventually end with low thyroid but like you mentioned that autoimmune flare can flare up your thyroid autoimmune response was Canaan cause more hormones to dump in the system, which can then create mood swings and irritability and anxiety difficulty sleeping and that can create issues as well. So you really want to look at autoimmune markers for the thyroid TPO thyroglobulin antibodies. You want to look at your thyroid levels because high or low or going to be significantly driving a lot of mood issues most of the time it’s going to be low because low is The Chronic place that people tend to end up but you will see with a cute flares that it will go high or more in the hyper side again in general. it’s going to be harder to catch that but if we see Levels of antibodies we can definitely assume those level of flares may be happening whether or not we catch the high-level on the test. If we know High antibodies are there then it makes sense that’s possible. And then of course some graves for sure, graves will be the other condition where were making antibodies. Where is thyroid receptor site antibodies are TSI with your thyroid stimulating immunoglobulins those can cause thyroid to make more hormones and that’s an autoimmune condition as well. Get ninety-five. 99% are going to be Hoshis, Hashimoto’s 1% grave. So in general, it’s more plausible. If you’re gambling person that you’re going to go on the Hashi side Less on the graves, but you know, you’ll typically were not going to ever run for Graves antibodies unless we see very high levels of thyroid levels like very high levels of T4 and T3, then we’ll definitely say, okay. Lets run TSI. Lets run thyroid what receptor antibodies.

Evan Brand: Your endocrinologist would probably even run even if you beg them. So a lot of times were ordering Special Labs because the primary doctor that someone may have the working with us. We may try to push them. Hey, you don’t try to get your endocrinologist to run this and they just won’t they’re very stubborn. Even when it comes to the TPO and TG antibodies despite the mass of massive increase even just the past 5 to 10 years of autoimmunity with thyroid. You would think that it’s like part of standard procedure and protocol now, but it’s still not my grandfather got his thyroid Labs run. It was literally just TSH and T4 and maybe like T3 uptake, but still nothing else and it’s just crazy. So what are they doing? They they modified your drug based on TSH, TSH one up. Lets give you a little bit more synthroid and people just don’t know why they’re not getting better.

Dr. Justin Marchegiani: Exactly and then conventional medicine will look at the graves thing and they’ll just say, okay. Well if you’re not in any hormone the right when you come in and your TSH is buried meaning it’s very low and let’s say below point 3.2.1. Then they may want to look Downstream at them some of those antibodies right? They may look at T4 and then I’m a look at TSI in the thyroid receptor site markers, but outside of that unless they see that they’re probably not going to do much. 

Evan Brand: Yeah, hopefully that’s what they do. But in some cases they may go straight to hey, we need to do radioactive iodine and try to just kill your thyroid off because youre youre over your thyroid overactive. I’m sorry that.

Dr. Justin Marchegiani: If they saw grave markers, that would be the next logical step. They didn’t want a thyroidectomy or they give u p t u or more time is all the shutdown of the thyroid activity or they give the radioactive iodine to just kill the thyroid to begin with.

Evan Brand: Not pretty.

Dr. Justin Marchegiani: No it’s not so thyroid flares because of Hashimoto’s well that may never come back on the TSH may never come out of balance enough for it to be an issue and your TSH may still be relatively in range, even though your antibodies are going up and down and your T3 may be low or could be going up or down to so you may not even see a problem with that.

Evan Brand: Alright so let’s talk about that was a good diversion. So I just wanted to make sure we hit. Community Casa del Carmen and no pesticides damaging the gut barrier damaging the blood-brain barrier. Even if you’re a vegan listening, please eat some meat but if you’re not, you know the vegetables or not benign neither you can still get a different herbicides pesticides excetera that still damaged your good gut bacteria and create leaky gut, even if youre saying everything I don’t need hormone me. Okay? Well the plants could do at 2 and then also the heavy metals, you know, we’ve seen a lot there’s just Google it look it up on PubMed your Googles evil because they’re suppressing a lot of help people. So use another search engine like one called ecosia ecosia. They plant trees every time you do a search every 10 searches the plant a tree for you so search on a Ecosia, PubMed Mercury depression or you know Mercury anxiety and any like bad mood something that you type up you can find a correlation with a various heavy metal. 

Dr. Justin Marchegiani: Excellent. I think it’s really really important. So heavy metals various pasta sides various toxins Roundup glyphosate. These are all going to be potentially stressors on your nervous system on your immune system on your brain. I told easiest thing is one just decrease the toxic overload. Just be eating organic higher-quality food. Drink really good clean filtered water. And then number two we can always give support to help run our Phase 1 Phase 2 and R2 toxification Pathways, that’s really important. We could do simple things like activated charcoal with you give sulfur-based Obito acids, we can get glutathione straight into liposomal former reduced form. We can get back Extra B vitamins and antioxidants like milk thistle with cumin and Resveratrol and really powerful things to help with inflammation and in donating antioxidants anything else. You want to highlight their on the detox. 

Evan Brand: I started over the weekend doing some glutathione and a nebulizer. there’s actually a brand out there which I can tell you about a bluetooth ion this mixed with a sodium bicarbonate that you can make Saline solution. I’ve read a Stephen Buhner, the herbalist that you and I love because of his work on Lyme and co-infections. He made a COPD protocol for people suffering with asthma and other lung conditions and came up with a nebulizer protocol with essential oils. And so I’m doing the nebulized glutathione by itself and you just need to put the face mask on you got the nebulizer and I just took a of 200 mg of glutathione intranasally and I tell you my brain yesterday was so clear like, amazingly clear and I’ve actually spoke with some of these people at the company who’ve gotten their patients off of IV glutathione and onto the nebulizer because they don’t have to drive anywhere to get poked with a needle is much cheaper and the results are being seen much better because it’s getting through the blood-brain barrier when you inhale the glutathione vs. IV is not so that’s like my new development on detox and I haven’t done it enough yet to to give you the full, you know the whole story but for right now, My story is very positive. 

Dr. Justin Marchegiani: Excellent. Very good. So I think we talked about some of the toxic things. And again, it’s pretty simple. it’s like you just got to look at the food. Look at the environments try to increase sweating the infrared sauna good clean hydration could get a grill to go clean water filter JustInHealth.com/water or the ones that I specifically used Evan probably has some as well EvanBrand.com and you can look at his shop as well. But that’s kind of things. I actually use and I recommend personally clean water organic food being able to digest your food and then we talked about some of the various binders that we can do like chlorella for that some of the heavy metals activated charcoal as it’s a really good multi-tasker for a lot very spent the night Clays or folded minerals are really good too. And then they also you know from what we may also do things like Z light or maybe even Coley star means to help that bind up some of that mold as well that could be there environmentally if that’s the case then well have to do some testing on the house and and look again. Is the root cause of that Dilantin I have a guest that were going to get on just a few minutes. It will talk all about that in the next podcast. I will be right after this show. 

Evan Brand: Yeah, we got to wrap it up so that you all can chat about mold. it’s going to be fun. But the sauna would be the last thing I would add animal wrap it up the sauna and I love sweating sweating is the key and you can look at if you just look up PubMed typing like ochratoxin sweat. You can read that mold toxins. In fact do come out when you sweat so there is proof behind that and there’s a reason that our ancestors did like sweat lodges and some of these ceremonial practices they sweat their butt often those things and they were probably detoxing too good thing for them as they did not have any of the hundreds of thousands of manmade modern chemicals that we have today. 

Dr. Justin Marchegiani: I think it’s important. that’s great. Awesome animal today was a great chat as always. Hope everyone enjoyed the podcast in the interview before you put your comment down below. Let us know things that you have used to help you detoxify good experience that you had and if you enjoy today¡̄s show, give us a share. We appreciate it, and you can write a review at EvanBrand.com/iTunes and JustInHealth.com/iTunes. We appreciate ya¡̄ll. Everyone has a phenomenal day and we’ll talk real soon.

Evan Brand: The clinical websites. If you want to reach out to Joe is clinically, please do so at his sight JustInHealth.com. You can reach out around the world. We can send test kit’s to your door. You don’t have to drive anywhere and wait in a boring dirty doctors office and read People magazine. You can do it from your house. So JustInHealth.com, and then my side is EvanBrand.com. We look forward to helping you were very grateful for the opportunity.

Dr. Justin Marchegiani: Love it, excellent. Awesome Evan, have a phenomenal day great chat with you is always will be back next week. Thank you. Everyone. 

Evan Brand: See you later. Bye.

Dr. Justin Marchegiani: Bye. Bye.


References:

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Audio Podcast:  

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Root Cause of Mood Issues| Podcast #229

Anxiety, depression and mood swings are more than just that. Those things are real and are not just in our mind.

In this episode, learn various causes of our mood swings and situations that trigger it. Also, natural remedies to ease it and getting to its root cause is included in today’s podcast. Stay tuned!

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

01:03 Causes of Mood Swings

05:40 Medications and Antidepressants

10:12 Going Natural

11:07 Proper Oxygenation

26:29 Environment Matters

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Dr. Justin Marchegiani: Hey there it’s Dr. Justin Marchegiani. Welcome back to the podcast. We have Evan Brand here. Today we’re gonna do a live podcast today on mood and natural mood solutions, getting to the root cause of your mood concerns. So we’re live on Facebook here as well live on YouTube. Make sure you click down below, leave us some comments, we want to know what you think we appreciate a share we appreciate the like. Obviously subscribe and don’t forget to smash the bell so you can get notifications of our awesome content coming up. So, Evan how are we doing today man?

Evan Brand: Hey man I’m doing pretty good. I’m looking for statistics right now to make sure we can discuss how many people have depression how many people have anxiety. The Center for Disease Control they study this stuff and so I want to make sure people understand this, its not just

Dr. Justin Marchegiani: (Cross talking.) Exactly

Evan Brand: One or two people out in the world that are struggling with mood issues, I mean it’s an epidemic so how big of an epidemic well that’s what I’m about to tell you.

Dr. Justin Marchegiani: Awesome, so let’s dive in. So we’re gonna be talking about mood issues. Now I kind of draw the line in a couple different areas because there’s gonna be mood issues that are like all the time and you’re gonna see this in men women and more women. You’re gonna see mood issues that are more cyclical that are involved with their cycle whether it’s at typically it’s in the be, sometimes at ovulation and usually throughout that luteal phase, that last part of a woman’s cycle a week maybe three tool days to a week before they actually menstruate or bleed, have the period that’s when you’re gonna see a lot of mood issues and that could be hormonally based. So you have mood issues that are more cyclical than like an everyday kind of thing there’s that number two blood sugar issues people that are on a reactive hypoglycemia roller coaster and live their life on a blood sugar roller coaster that’s gonna be a problem. Number three, just poor nutrition. Like you’re not getting enough B vitamins and magnesium and amino acids in your body so you’re just – your diet’s just poor nutritionally it’s not nutritionally dense to provide the building blocks, to make all the brain chemicals, and then number four I would say is a malabsorption issue. Meaning, you don’t have the your digestion, is it off, or you don’t have the digestive secretions because of infection or food allergens or gut stress you’re not able to break down those nutrients so maybe the nutrients are coming in but we’re having a deficit on the breakdown side if you will

Evan Brand: Yeah, it’s not what you eat, it’s what do you digest from what you eat. So you could have a Paleo diet yes, but if you’re still on an acid blocker or you have some infection you could still be at a deficiency of those amino acids that you need to manufacture brain chemicals

Dr. Justin Marchegiani: Exactly, and then number five but kind of dovetail with the female hormone issue, but that’d be more on the adrenal stress side highs and lows in cortisol or cortisol rhythm issues. Now, I would say a lot of women that have the cyclical issues probably have an adrenal issue, but there are some people that may have all the time issues that are more Audrina based indoor men may have adrenal based issues, and then connecting to that, I would say with me the thyroid low thyroid hormone is commonly shows up as anxiety. They’ve done studies where they’ve taken people with anxiety and mood issues given one group, lithium the other group actual t3 and they found the actual t3 thyroid hormone saw some of the mood related issues and better than the lithium did. So those are kind of the big four or five things I’m trying to dovetail and we can connect any comments on that the brief over you Evan.

Evan Brand: Yeah, so what symptoms are we talking like when we say mood issues are we hitting, I mean we already did an anxiety podcast, we could talk about depression and that’s part of it are we just saying mood issues as a whole, I mean that could be irritability, that could be anger, I mean do we just tie it all together because really it’s all connected.

Dr. Justin Marchegiani: Yeah, your debility, anger, anxiety, depression and then typically those things tend to dovetail with fatigue I think the only if we’re unique most people that have fatigue tend to have those issues, with the exception of maybe anxiety. I’ve seen some people that are very energetic but are anxious kind of that tire but why are you kind of thing but they may not be like fatigue so to speak. So typically you’re gonna see almost all of those issues have a fatigue backbone with the exception of anxiety maybe but you can still be anxious and tired though –

Evan Brand: Yeah, so depression specifically what I found here for statistics in the US about 10% of the US population has reported depression, so I mean how many people are depressed that have not reported it probably a huge amount. So you know if we estimate the US population over 300 million people, 10%, that’s what 30 million people, yes a lot of people, so you know not just you and your brother and your sister and your cousin, no, I mean this is everywhere you go I think the numbers are probably way higher than 10%. I think it’s just that people are not reporting it you know, what are you gonna do like you’re gonna go to your doctor you’re depressed a lot of people are catching on to the fact that all they’re gonna do is get a prescription pad written form and in your intro you said nothing about a deficiency of depression medication, you didn’t say anything about a deficiency of anti-anxiety medication, so people know they know that’s the only supposed cure that they’re gonna get is those drugs and people don’t want to do, I mean you and I talk to people every single day all day and a lot of them do have depression and they know I can’t get help from conventional psychiatry or doctors so then they come to us because they know there’s something else going on it’s not just a pill that I’m missing to fix my depression it’s something underlying and I had depression for I don’t know 10 years I mean as long as I could remember and my mood started to lift significantly after I worked on my gut.

Dr. Justin Marchegiani: 100% now looking at a lot of medications acutely a medication may be necessary if you’re in a suicidal place that that may make sense but you have to work with someone to get to the root cause. The problem is most antidepressants that actually don’t work in the long run. What happens is the dose has to be raised up and then as you increase the dose your chance of side-effects increase and side-effects of antidepressants can be weight gain, it could be low libido, it could be other mood issues, it could be energy issue, so there’s other issues that could happen spinning off a various side effects. So like within the depressants we have SSRI medications right that’s your selective serotonin reuptake inhibitors, these are like your pre and post synaptic neuron you have all the the brain chemicals here in between the synapses is like your serotonin and there’s react ape ports on the presynaptic neuron where these chemicalsget recycled and a reuptake inhibitor it blocks this. So imagine putting my hand over this part and that way these chemicals cannot go back into that presynaptic neuron and if you guys are listening on podcast feel free and click below to see the YouTube links that you can see my, my little hand puppetry if you will. So that’s kind of SSRI you have SSNRI which is like Selective’s Norepinephrine Reuptake Inhibitor so SNRI. Now, looking at norepinephrine dopamine which is similar you have things like wellbutrin, there’s other medications that are in that category that are working more on adrenaline dopamine kind of cascade because dopamine’s a precursor to adrenaline. So you have those medications on the depression side there’s new lines of antidepressant medications coming out working on brain inflammation. The conventional medicine is starting to understand that brain inflammation is a big impact on mood so they’re giving you these medications to help with that. Now, you got to be careful because anytime you don’t get to the root cause you create potential side effects, so these medications are so new coming out not even sure if they’re even from market yet they’re in the testing process now, so the side effects I’m not sure of yet but I guarantee you there’ll be a whole bunch. Now, looking at functional medicine in nutrition we want to get to the root cause of that brain inflammation, so one of the first thing we look at is to diet and the first thing after that is the gut because inflammation in the gut drastically causes inflammation in the brain, we have this the tight junctions open up this leaky gut gastro intestinal permeability phenomenon occurs undigested particulate bacteria foods gluten dairy get into the bloodstream, they can make their way up to the brain and make an activate our microglial cells which can create more cognitive issues more brain fog and more mood issues. So depression is a really big component so just kind of laying out the medication here and then obviously we have like our our gaba like as a pain medications which are gonna be working more on the gaba receptor sites and then we have ourold tricyclic s–from the 80s which are antidepressants from the 80s, less side effects with those but those still are kind of a weaker SSRI and —

Evan Brand: Well the problem with the benzos is that they’re highly addictive and if you try to come off of those you have a big withdrawal period where there’s going to be potentially more anxiety, more depression, panic attacks, I mean I’ve had people who come to me after they tried to go cold turkey off of a benzo and they’re having night sweats and panic attacks it’s like no you can’t do that, you know those drugs were really really effective so it’s just not something you can do on your own, you really have to have a doctor to help get you off of those drugs and a big problem is two people that are trying to mix supplements with medications – I mean you can’t just go take a SSRI and then go take 500 milligrams of 5-htp that’s just not something that you want to do it’s rare and I haven’t seen any cases of it personally but it’s called serotonin syndrome and that’s when you can boost up serotonin way too much with the drug and a nutrient so this isn’t. I mean when you’re talking brain chemistry you don’t want to come in there and just go to Whole Foods, buy a bunch of amino acids and start popping them if you don’t know what you’re doing

Dr. Justin Marchegiani: Yeah, and the side effects are pretty prolific like we talked about nausea, fatigue, poor sleep, dry mouth, blurred vision, constipation, low libido, weight gain, so all of these things can, can add to the milieu of symptoms that are already there and we’re not getting to the root cause, so we kind of lead it the medications we talked about how important that is we obviously know foods really important because foods where all the building blocks come from so we want diets a very important very nutrient-dense with lots of good healthy B vitamins especially b6 which helps activate a lot of our brain chemicals. So obviously like a paleo temple it’s gonna be a great starting point with healthy organic green vegetables you know lower sugar fruit lots of good anti-inflammatory compounds they’re good healthy omega-3 fats which can help a brain inflammation and help with inflammation in general and lots of healthy good animal products that are gonna be grass-fed not grain fed with all the roundup and pesticides and junk.

Evan Brand: Yeah. I’ve noticed a big difference myself with the fish oil just taking that tends to just level my mood out it’s not like it’s an any depressant effect like you would get from something like rhodiola, that’s one of my favourite adaptogenic herbs for depression. It’s not that significant but it just kind of makes you more even keel, where something like an adaptogen is going to help really boost you and you’re gonna feel altered, almost like you have a buzz from the herbs like, whoa I’m I feel happy I feel great. Yeah ___[10:57] is good for that gotu kola is good. I would say ginkgo could be in that category too because ginkgo will help with the blood flow in the brain, you know some of it could just be poor oxygenation what you think like if someone’s sedentary and maybe they have poor circulation, maybe they have mold issues that’s blocking nitric oxide, I mean how much of depression do you think is an oxygen related issue.

Dr. Justin Marchegiani: Yeah, I mean anytime you have poor or increased coagulation meaning blood is kind of viscous, it’s like molasses things aren’t flowing well. Exercise helps improve that just getting inflammation down when you’re more inflamed and you have more inflammatory cytokines or interleukins in your bloodstream. Things get stickier and they’re not gonna flow as well, so movement helps getting the inflammation down, helps doing things like ginger tea. Ginger can be helpful. Fish oil is a natural blood thinner so you talk about fish oil. Part of the mechanism on fish oil works is it helps that coagula, it prevents things from clotting and sticking and also a fish oil is like a weak MAO inhibitor so basically, MAO is another kind of enzyme that metabolizes a lot of these brain chemicals kind of naturally and this it has a way of delaying that metabolism so not quite a drug like effect but it does have a mild effect there and again when you do things that are more natural and have mild effects. You have less side effects so fish oil’s wonderful with that also things like St. John’s Wort has some really good depression antidepressant qualities too and a lot of times they’re working on indirectly. They have anti-inflammatory effects they have which then helps with blood flow which then they tend to have maybe a mild MAO kind of you know decreasing the metabolism of our brain chemicals kind of mechanism that’s happening at play. Also one thing about gluten they’ve done, studies on gluten where gluten decreases blood flow to the frontal cortex so oh you have you know your garden hoses up the side of your head is called your carotid they gave people basically functional MRIs and they looked at blood flow and activation and the frontal cortex pre and post gluten and they saw significant reduction in blood flow to the frontal cortex the neocortex which is what makes us humans compared to animals and they saw a significant reduction and also significant reduction in migraines when that blood flow was supported. Meaning, when they cut the gluten down migraine stopped and they also saw that the blood flow was coming up when that happened so kind of outlined the mechanism. Blood flow is a really important component so anytime we can decrease the coagulate, meaning things sticking and we can improve the blood flow, like we talked about that makes a huge difference now exercise helps with the blood flow it also helps stimulate beta endorphin which is the natural antidepressant. It hits that opiate receptor and it’s a nineteen amino acid compound, meaning you need to be digesting and having good protein so the more you’re vegan and vegetarian and you’re not getting good quality proteins in there or you’re not supplementing additional proteins and b12 as a vegetarian vegan in omega-3 from algae you’re in a worse situation because you’re not getting those certain nutrients in

Evan Brand: Yeah, I’ve got my wife on some herbs right now St. John’s Wort passion flower motherwort dandelion Damiana black cohosh this is a kind of a postpartum mood remedy that we’re using that’s an herbal tincture and I’ve tried it and I feel great. I feel a lift from it too. So, this is something we’re doing for her just because you know a lot of depression we didn’t talk about this yet, a lot of depression is postpartum but then it never lifts right you and I talk with moms every single week. We’ll talk with the mom who says you know you and I will do a history together we’ll say okay let’s go back in time when did this depression start or when did this anxiety start. We’re always trying to make our timeline and so a lot of moms will say, wow this was after my first kid or after my second kid or after my third kid, the depression came on and it never went away and some of that steroid related because we do see a lot of postpartum Hashimoto’s where all the sudden the immune system goes crazy antibodies go up. The thyroid gets attacked the woman becomes hypo under functioning with thyroid or maybe she’s alternating between hypo and hyper and then she’s feeling bad because of that and so these herbs can come in and really help to regulate not only thyroid function, you could do some adaptogens to help adrenal thyroid but then the mood ones too like passion flower. I love it you know I think it’s something everybody could benefit from especially if you’re more on the anxious side where you’re stuck in traffic and you’re freaking out even my grandfather the other day he told me he said, Evan I can’t handle traffic anymore, and my grandma starts making fun of them they were talking about how they got stuck in rush-hour traffic and my grandpa was kind of freaking out kind of panicking getting anxious and he never used to be like that. So I told him, hey maybe we can get you a passionflower tincture. You put it in your purse, you know my grandma’s purse and take a shot of that next time you get stuck in traffic

Dr. Justin Marchegiani: Exactly, now some natural ways that you can improve GABA levels is there’s some people to talk about GABA is too small or too large to pass the blood-brain barrier, but yeah I don’t know I kind of go back and forth on that so there’s that so you could take a product called Pharma GABA and you can do with sublingually so I’m gonna take one now to kind of promote my parasympathetic nervous system responses.

Evan Brand: I love them. They’re great. I chew them up too so great, great tasting.

Dr. Justin Marchegiani: Anytime you’re supporting adrenal stress right because GABA is the brake on the sympathetic fight-or-flight nervous system so anytime you can kind of bring cortisol and adrenaline back into balance, it’s helpful so things that you can do are gonna be ___[16:37] is gonna be excellent, magnesium will be excellent, ashwagandha will be excellent as well that really helps curtail, let’s just say a lot of the at the HPA access dysfunction.

Evan Brand: Let’s go into magnesium a bit because you hit that one but I don’t want to gloss over because magnesium is a huge needle mover. Maybe let’s dive into just a couple different forms for people that they could use. So last night I did some magnesium oil. I did some spray on my legs, my calves, I started to feel a little cramp coming on I thought you know, I was in the sauna over the weekend I was sweating I might not have replenished enough of my magnesium so I did magnesium oil and I slept much better with the oil. So that’s one topical form and then a lot of times you and I talked about magnesium glycinate, ___[17:23]I’ve had really good success with ___[17:25] especially for like muscle relaxation.

Dr. Justin Marchegiani: Exactly, so magnesium is gonna be excellent. It’s a natural beta blocker so it can relax your heart so your heart’s not beating out of your chest. Obviously there’s like a thousand enzymatic roles in the body from magnesium so it’s in help with motility it’s in help but blood sugar metabolism it’s in hell but inflammation in the brain I think part of the mechanism and how magnesium works , ___[17:51] it’s highly anti-inflammatory to the brain. I saw a lecture with Russel Blaylock who’s a famous neurosurgeon and he said clinically when he operated on people and he would give them post-op stuck the metal magnesium they heal better than his colleagues patients that had the same procedure, it was like a remarkable difference. He said so supplementing additional magnesium really made a big difference.

Evan Brand: Magnesium threonate, that’s amazing magnesium threonate would be the other form I would recommend just because we do know magnesium threonate and a-actually crosses the blood-brain barrier so when you’re talking about gaba, you know supposedly being too big to cross the blood-brain barrier and the pharma gaba is smaller and is more easily readily available to get through the barrier same thing with magnesium threonate. So yeah if you do one to two grams of threonate that’s going to get to the brain and you’ll feel significant changes, I mean we’ve used it for people with PTSD. You know some of the literature we use professional healthcare companies to manufacture our products and they’ll give us some text sheets on the back end and they’ll have a whole list of symptoms why you would use threonate and PTSD and anxiety is one of them so we know these people think of anybody who’s at a stressful or traumatic event which is pretty much every human ever obviously some more than others. The threonate to me is a good a good remedy I mean if I had like a a trauma clinic or like a PTSD clinic or something or a mental health clinic where you know let’s say you’ve got people having mental breakdowns, you know kind of back in the day like my grandmother her grandmother would talk about oh if you have a mental breakdown you go to this hospital you stay in there for a month and they send you home. I guarantee they weren’t using magnesium threonate because it wasn’t invented back then but that would be something I would have in the protocol for people rather than, yeah, automatically going to the prescriptions.

Dr. Justin Marchegiani: Yeah, I know Blaylock. I don’t even think Blaylock was using threonate, back things it wasn’t really that big.

Evan Brand: Yeah.

Dr. Justin Marchegiani: Using a standard citrate, probably citrate it’s fine. It’s a cheaper version you can get it in natural calm, it can cause bowel, your bowels to move so some people do better with the ___[19:51]  or a or glycinate or if you know this cognitive issues we can do a magnesium that is a threonate, that better at crossing the blood-brain barrier we love that.

Evan Brand: Yes, I wanted to give you a brief diversion on the magnesium piece because here magnesium, but then they don’t know there’s a lot of different varieties of it that have different effects .

Dr. Justin Marchegiani: Mm-hmm yeah, exactly. Now, next passionflower is great which is otherwise known as melissa officinalis. Another great relaxing kind of herb. It tends to be almost like a natural.

Evan Brand: melissa is a lemon balm.

Dr. Justin Marchegiani: Yeah, oh yeah I’m sorry yeah yeah, the same thing Melissa and lemon balm tend to be relaxing so a lot of like natural hyperthyroid formulas have that in it so Melissa Melissa and lemon balm are over here passion flowers is similar and then Valerians both sent when they didn’t have relaxing kind of dampening effects and yeah, thank you.

Evan Brand: Yeah theLlatin on because you said passion flower, then you said otherwise Melissa yeah ,passion flowers Latin name is like Pasi flora something and carnie incarnate, uh, something like that I don’t really.

Dr. Justin Marchegiani: It’s, it’s lemon balm and Melissa are the same thing yeah, flour and then valerian excellent also we can add kava to the mix there’s been research on kava from the Cochrane Database. You know, finding it’s very effective at helping with anxiety without the side effects so kava is excellent.

Evan Brand: Have you tried kava?

Dr. Justin Marchegiani: I’ve tried it supplementally a couple times. I’ve tried it, someone made me kava tea before, it’s big in Fiji I think it’s very helpful it basically activates those GABA-A receptors is GABA-A and GABA-B and it really activates the A receptors in the brain so it can really help kind of chill you out and relax you.

Evan Brand: I went-I’m going to a kava bar one time when I was down in Austin and drink a shot of it, it tasted like – it tasted and looked like mud water.

Dr. Justin Marchegiani: That’s exactly how it tasted look, yeah.

Evan Brand: And I was I was altered, I thought man I don’t know if I’m gonna be able to drive home. I mean I’m really sensitive so maybe my GABA system just got flooded but I was sitting back in the chair kind of like, whoa I mean it hit me like a ton of bricks.

Dr. Justin Marchegiani: I’ve also seen CBD do very well in the mood side too so that’s ___[22:01]  with the non active THC has, I think is very helpful too I always tend to lean more on nutrition first, so like the B vitamins, b6, magnesium ,will also do higher dose l-theanine amino acid which can help promote GABA production stuff the mental gammas I tend to promote those along with the long-standing adaptogens that have a long term success record, like ashwagandha is excellence I’d say Kava after that’s wonderful lots of studies on it and then- um-any comments on that before we go to the next step?

Evan Brand: Yeah CBD has been helpful for me too. I give it to my daughter so if she complains of a headache or a bellyache or if she seems restless at night we’ll just give her a one milliliter dose which the brand I carry is a 10 milligram CBD, she’ll go right to sleep so it’s a really good settling thing and so for kids too. I mean I didn’t mention the statistics I was looking at some of this stuff from the Center for Disease Control. I mean we’re seeing we’re seeing 20 to 30 percent of children now are reporting anxiety and depression so I have moms that are telling me their kids are suicidal at 5 10 years old. I mean, when I was 5 and 10 years old I had no comprehension of death or mortality so I don’t know if it’s you know the the TV shows and the violence that kids are exposed to in other places that I wasn’t because I was outside on my bike all the time or what but you know as a kid I don’t remember other kids being anxious and depressed. Now I mean it’s almost every single kid that I see there’s an underlying anxiety problem associated with as you mentioned the gut you know we see these kids eating conventional food or get tons of glyphosate they’re good bacteria killed off the bacterial overgrowth are making toxins which are depressing and causing anxiety and the kids, so I mean there is a root cause for the kids too. It’s not where they need to be put on medication immediately same thing with ADHD. ou know these kids are getting diagnosed with ADHD we see that get better with fixing the gut to 100% and there’s herbs for kids too so there’s actually I mean, technically we can just dose adult formulas down but there are some special kids formulas that we do use that are specifically maybe they have a glycerine base as opposed to an alcohol base and passionflower skullcap, things like that you can use those with kids as well.

Dr. Justin Marchegiani: 100% also there’s something called people, may know it call phenibut or for amino 3 phenol butyric acid. Now this components a little bit controversial because there’s, there can be some addictive qualities to it it’s essentially a GABA agonist. Supposedly crosses the blood-brain better it’s a GABA agonist I’ve had some people that had phenomenal results with it ,but I’ve seen it I’ve seen it become a little bit more addictive and people become dependent upon it so it’s one of those things as a double-edged sword. I would never go to it first but I’ve seen people that have done very well with it I think it would probably be better than peeing on a benzo long term but I would always try that, that mean the last thing I would potentially ever go to in my arsenal because of so the so-called some addictive qualities to it

Evan Brand: Yeah, I mean it helped, it helped change my change my life and get me through some tough times but, yeah, there’s a huge risk with people not respecting it and overusing it and down regulating GABA so much that you get more anxious you get more panic etc. When you try to get off of it whereas the pharma GABA that you just chewed up you’re not gonna have that potential for that one.

Dr. Justin Marchegiani: Exactly, yeah, exactly, so we have a lot of the supplementation I would also say if it just depends – because if we have a high cortisol state things that can help lower cortisol make a big difference. Some people have a very low cortisol state and some of their anxiety and mood issues is driven by low cortisol so some people think it’s like, hey this is the solution for that, well it really depends because what if you have low adrenaline and low cortisol well a lot of your anxiety and mood stuff could be from the lower state versus higher anxiety and high cortisol or higher adrenaline and high cortisol be many things to bring it down so we may be doing things more like phosphorylated serine to bring it down and actual gana we may do things to bring it up that are more stimulating like ginseng or licorice if it’s chronically low, and or tyrosine if we see low adrenaline so we got a look at what the pattern is because sometimes extreme high and lows can feel the same and that’s hard people to wrap their heads around.

Evan Brand: Yeah that’s a good point. I mean I had a woman in college who she, she was in Hawaii I remember that we found out her her dorm was super moldy and that’s why she was having all these panic attacks so that was cool too, but she had extremely, extremely high cortisol but just based on doing the initial intake and we talked over her symptoms. She was exhausted couldn’t get out of bed etc, we thought, oh my god I bet her cortisol has flatlined, no it was the opposite it was very sky-high so this is why you know you listen to a podcast you think, oh I’ve got low cortisol I’m tired I’m gonna go take a bunch of licorice, no way if we would have given that to that girl with high cortisol we would have made her blood pressure go up she would have had more anxiety more panic so this is why you have to test you don’t want to guess with this stuff you really want to get the data, maybe we should talk about that now do you think we should move on to testing.

Dr. Justin Marchegiani: Yeah so I would say off the bat right we got to make sure the guts functioning well right the absorption of these nutrition where inflammation kind of gets into the bloodstream and goes to the brain really depends a lot on gut inflammation so good high-quality stool testing. I know we talked about doing the GI map task we like there’s a couple others that we do as well but if someone wants to dig in deeper to the gut we have to really fully assess that.

Evan Brand: Yeah so the guts huge urine I mean you’re in great we test for micro toxins through urine we test for chemicals we test for amino acid metabolism we test for bacterial overgrowth and Candida which can affect the mood so getting a urine test will be key and then getting the saliva adrenal test or a urine I don’t know do you do salivary adrenals anymore are you just doing urine

Dr. Justin Marchegiani: I know sometimes salivary adrenals but I’ve been liking the urinary metabolites because I see a lot of women that have a hard time metabolizing estrogen, so it’s nice to be able to run that one because I can also see how they’re metabolizing the hormones too. So that totally helps if you’re a female and you have estrogen dominant issues. So I maintain a new right estrogen dominance right that that ratio of progesterone estrogen drops right progesterone and estrogen drop like this. Meaning everything drops but progesterone drops faster so it’s nice to be able to see that because that can be a big mood issue – remember progesterone is a natural GABA chloride channel opener meaning we can promote GABA in the brain with healthy levels of progesterone so part of your GABA issue could be lower progesterone as a woman and also progesterone is very anti-inflammatory in the brain even with men with like concussions or any brain trauma they’ll give a couple hundred milligrams of progesterone for a few days after brain trauma to actually curtail the inflammation in the brain, so progesterone is very anti-inflammatory because of its cortisol building block effects of progesterone can help brain inflammation in brain trauma.

Evan Brand: Now let’s go a little further then are you talking supplementing progesterone, are you taking, doing some of these specialized maca extracts to help regulate progesterone estrogen?

Dr. Justin Marchegiani: Both no, but it depends on how bad it is. If it’s slightly out of balance we always lean to herbs and diet and natural components, if it’s significantly out of balance will use the bioidentical plant base and we’ll dosed it accordingly to accelerate the results.

Evan Brand: Okay and then like estrogen dominance, you’re talking removing plastics removing phthalates and other things from the makeup and environment. Plus maybe you’re gonna be throwing in some herbs to help regulate that maybe like the do you pronounce it ___[29:41]  

Dr. Justin Marchegiani: Yeah ___[29:42]  more gonna help on the testosterone side, but on the inside we would do more like calcium to ___[29:47]  and all methane, fiber. Right these things are really helpful also there’s some some seed protocols where they’ll, do they’ll, do what’s the seed-

Evan Brand: Alpha linoleic acid omega-3 flax

Dr. Justin Marchegiani: Yeah exceed in the first half of the cycle so f for first half of the cycle and then typically a lot of sesame seeds for the second half of the cycle F &S; sometimes they’ll throw some pumpkin seed in there as well and that can help bind up some of the estrogen metabolites too.

Evan Brand: Oh interesting I was going to say I was reading some studies over the weekend about detoxing mycotoxins and actually one of the suggest that things to do was take flaxseed to help bind to toxins so that’s pretty cool it’ll bind the excess estrogen as well.

Dr. Justin Marchegiani: Yeah I think that’s in our ___[30:36] buying product too isn’t it?

Evan Brand: Yes,

Dr. Justin Marchegiani: Exactly, so that’s really good for mycotoxins and mold and then we already kind of dovetail through the mold mycotoxin coagulate issue it’s in a decreased blood flow so if you have any mold or environmental stuff that could easily be affecting how the blood is flowing to the brain and obviously potentially even getting to the brain and activating those microglial cells – that’s very possible.

Evan Brand: Yeah I’ve got a story people like stories right so we get into the geekiest and then people like zone out on us so here’s a here’s a quick stor.y I was working with a teacher last week she’s in her sixties she’s about to retire and we were discussing her urine test we looked at her urine for mycotoxin. She had a lot of different mold problems and I gave her some of these little plates these little petri dishes and we took him to her school she put him in her classroom. Her classroom came back very moldy and she goes, oh my god. you know this explains why after summer break you know all the teachers leave they come back and she says her and all of her colleagues talk about how they get depressed they get fat they get tired they get anxious etc, when they come back to school. Now obviously people would say, oh it’s just the kids stressing them out, no it’s she’s getting out of the moldy environment. For the summer the mold grows there in the summer they probably don’t run the air conditioners because they’re saving money on budget. during the summer they come back school starts in August or whenever and then they get sick again but luckily in her case she’s retiring so it didn’t matter but this is a real issue with a lot of women in office buildings or school buildings if you, if you feel worse, if you feel more tired, you feel more depressed etc when you go into a certain environment that might not just be the stress of the job or the bad boss this could be a toxin or pollutant in there so you may need to get like a HEPA filter in your classroom or a portable HEPA filter to put on your desk. if you’re in a cubicle and you’ve got people wearing perfume and stuff around you right you may need to try to make yourself have a little healthy bubble if you can’t leave or fix the environment that you have to work in.

Dr. Justin Marchegiani: 100% also be on top of your environment, so we’ve already done plate testing in your house, in my house, my basement, my new office. And my basement tested great for mold but I’m noticing that the humidity contents going up as we get closer to the summer so like my first two floors it’s like 43 44 % but then my basement where my office is is that 56%. Now the problem is I would run the air conditioning more to knock it down but the problem is it’s already sixty five degrees right now it’s already kind of cool because of you know the nature of basement so because of that because I’m on top of it I’m gonna be getting a whole house dehumidifier. Specific for basement dwellings to remove the humidity from the air that way I don’t have to drop the temperature I can keep the temperature where it’s at and just suck the moisture out of the air and drain it out so based on your feedback, I’m already on top of that and everyone listening, if you have if you have a moldy environment or any environmental symptoms but there are no leaks check the humidity content of your house.

Evan Brand: Yeah it sounds like we’re coming out of left field, like okay we’re talking about GABA supplements now we’re talking about your environment. Your environment it’s a huge piece of I mean, think of how much time you spend indoors, it’s like what ninety five percent of your day. Most people are indoors so the air you breathe can affect your nervous system we know just based on looking at the EPA’s work where they’re sampling the homes that live near highways we know that the pollution from a major highway gets into the home and that actually increases cortisol so you actually have a shorter life span if you live close to a major highway or a busy road or a busy intersection they’ve done. Studies on people that live near four-way stop signs and four-way traffic lights and if you live near those busy intersections the cars are breaking the brake dust gets into the air it goes into your home it contaminates you know your children’s lungs your lungs etc so if you’re in a busy area and even if you’re not in a busier. I mean, here’s the deal, you know I’ve got five acres, I’m out in the country but we still have bad air quality because of the way the wind blows and so when the summer starts heating up the pollutants from the car exhaust will have air quality alert days all the time during the summer so that’s the time where you want air purifiers in your home, in your space. Making sure your airs clean now if you go outside and play sure you’re going to get exposed to the crap, but if you’re in your home you need it to be a sanctuary in terms of free of extra EMF free of mold free of extra humidity free of pollutants you know this is very, very critical especially your bedroom.

Dr. Justin Marchegiani: 100% that’s why we recommend also high quality air filtration as well if you go to my site justinhealth.com/ shop, you can click on the recommended products tab and look at some of the products that I recommend, that I personally havem I have multiple same thing. If you go to evanbrand.com and click on his store button, he has similar products that we both recommend and talk about and share with each other but if you guys are enjoying this cause and that’s a great way to support us so you can get great products we’ve already tested for y’all.

Evan Brand: Yep, yeah we’ve got like four different brain. I’m always experimenting so we’re trying to get you the best of the best. There’s a lot of crap out there like if you go to Target or Walmart and you go buy a air purifiers thats better than nothing, yes, but is it the best of the best? Probably not, no.

Dr. Justin Marchegiani: Exactly.

Evan Brand: You get what I pay for you, get what you pay for. You can go buy a $50 HEPA filte.r but you know, I buy more like $500 HEPA filters but they’re you know they’re built like a tank and they’re quality so-

Dr. Justin Marchegiani:  Yeah it’s kind of we are getting like almost a surgical base kind of air filtration.

Evan Brand: Yeah it’s like a hospital in my house in terms of the, the air purity not the not the Candida everywhere on the walls that is affecting people. Have you read about that the candida like ___[36:06] outbreak? It’s very dangerous.

Yes, yes I’ve seen that it’s pretty bad.

Evan Brand:Hhospitals don’t know what to do. I mean they’re, they’re running out of options, you know the antifungal drugs are not working.

Dr. Justin Marchegiani:  Yeah they need to be using more silver and probably even more specific probiotics because I think a lot of these Candida things are coming potentially from people post antibiotic supplementation or post probiotic prescription so I think the components big also, I know surgically my mom’s a surgical nurse for 45 years they’re using a lot more silver, now they’re wrapping all joints in like a silver cellophane after surgery to prevent MRSA an issue, so silver is already being used at that surgical level.

Evan Brand: Good, good yeah we still need more help though, I mean when the center Disease Control says, hey basically don’t even go in a hospital unless you have to, I mean, that’s pretty scary.

Dr. Justin Marchegiani:  Oh yeah like if I have to go somewhere, I’m, I’m calling a doctor and going directly in paying cash or I’m going to an urgent care place where you’re kind of in and out versus the conventional ER forget about.

Evan Brand: It, it’s just not it’s just not safe so you know obviously the, the hospitals are there sometimes we have to go there but when we’re talking about mood related issues. I mean you could have something as simple as a panic attack, you think you’re dying because if a panic attack you go to the ER and then they go run a bunch of tests on you and send you home with anxiety prescription and nothing was wrong and now you expose yourself to all these pathogens in the hospital and you come home more sick than you went in that’s just not a good thing to do.

Dr. Justin Marchegiani:  Exactly, yeah, 100% same, and today was a great podcast, is there anything else you want to, to the show here?

Evan Brand: The last thing blood sugar. We’ve done so many we always talk about blood sugar but I just forgot to mention it because when we talking anxiety, mood issues there’s so many pieces of the puzzle when I feel low, if I feel depressed, if I feel anxious, if I feel like oh my heart’s starting to race a little bit, I’ll go prick my finger and sometimes I’m at – at like a 68 on my alt my glucose. Is just too low I’m getting that adrenaline response which is driving anxiety so I mean, don’t you know we got so many people practicing intermittent fasting and doing low carb diets etc, and these people depending on the, the stress and their life they may be less tolerable of lower carb less tolerable of intermittent fasting meaning a intermittent fasting was too stressful so I just currently don’t do it and I was noticing that I felt more anxious on those fasts and so for me blood sugar stability is a huge component.

Dr. Justin Marchegiani:   Yep I 100% agree and if you guys are liking this content give us the thumbs up, smash that like button and hit the bell as well so you can get notifications. I’ll be doing a live thyroid reset summit QA for all the people that were involved in the thyroid summit so if you guys are enjoying this I am set to go live here another 40 minutes we’ll be taking only thyroid Q&A; topics anyone listening to this as well head over to thyroid reset. Some of oumake sure you subscribe there as well. Evan, anything else?

Evan Brand: Our plugs people have these issues every day all day these are things we work with every day all day ,so if you want help from Justin please reach out to his website justinhealth.com you can schedule a call from around the world. For me my site is evanbrand.com. We don’t care who you work with as long as you get the help you need we’re just happy to be, a be of service to you guys.

Dr. Justin Marchegiani:  Yeah 99.9% of people that we help be never either me cuz they get access to our free content and they start utilizing it and then some need you know deeper more hand-holding and deeper assessment so that’s why we’re here and glad that everyone is enjoying the podcast and we’ll be back. Evan take care

Evan Brand: You too, take care bye

Dr. Justin Marchegiani:  Take care, bye.


References:

https://www.evanbrand.com/

https://justinhealth.com/

https://www.youtube.com/watch?v=wqKqHwkdOpc

Improve Your Mood Part 1 – Podcast #28

Dr. Justin Marchegiani and Baris Harvey reviews why your mood is off and shares with the listeners some simple things you can do to help get it back on track. Basically, this is a discussion regarding mood and neurotransmitter health. So if you have overthinking and anxiety issues, listen to this podcast learn how to deal with them. Dr. Justin also explains the importance of female hormones and the adrenals working for PMS, mood issues, or disruption of cycle.
mood disorders

Find out about the key foundational principles that will definitely help with mood changes.  Also learn about the types of food you should eat to keep your blood sugar regulated which is greatly improve your energy and mood throughout the day. Discover how neurotransmitters allow us to feel good in this podcast. Get information on the recommended ratio when taking 5-HTP and L-tyrosine.

In this episode, topics include:

4:58   Fixing your mood with foundational principles

12:27   Foods to eat and to avoid

15:19   Protein, amino acids, and neutrotransmitters

24:40   Female hormones and supplements

33:24   5-HTP and serontonin & L-tyrosine and dopamine

 

itune

 

 

youtuve

 

 

Podcast: Play in New Window|Download

Baris Harvey:  Welcome to another awesome episode of Beyond Wellness Radio.  Before we go into today’s show, I wanna tell you guys about our newsletter.  Go to BeyondWellnessRadio.com and hit the button that says Newsletter Sign Up.  By doing this, you’ll never miss out on an episode.  Be the first ones to hear it as it is sent out to your inbox each week.  Want even more?  Make sure that you go above and click on Just In Health or Really Healthy Now or access straight to us the practitioners.  You can go ahead and send us an email and talk to us one-on-one and even get yourself a free 15-minute consultation.  Dr. Justin even has a free video series on How To Fix Your Thyroid.  So that being said, thank you guys for listening to another episode and coming on.

How’s it going, Dr. Justin?

Dr. Justin Marchegiani:  Baris, it’s going great, man.  How are your holidays?  How was the New Year?

Baris Harvey:  It went awesome.  Got–got some–some new clothes, some new jeans, I’m looking a little dapper so I appreciate that shout out to my mom for that.  How’s it going–how was your holidays?

Dr. Justin Marchegiani:  Holidays are great, very good. I’m restful, got a little–little bit of a cold just kinda leading into the holiday but I was kinda got back on my immune-boosting protocol and I was able to get over it in just a few days and–and I’m, you know, definitely better for it.  I mean, most of the conventional solutions for getting a cold really there aren’t much.  I mean, it’s either get a flu vaccine ahead of time or Tamiflu for the most part.

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  But there’s a lot of nutrients in the national medicine realm and that probably is a good podcast that we should do maybe next week.  We’ll–

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  Add that to the queue.

Baris Harvey:  Yeah, we’ll definitely add that one.  Alright, as a matter of fact, I’ll write that down right now–immune.  Alright, so I–I know one thing for me was like I actually did really well when it came to vaccines because I know a lot of people got sick because, you know, the weather and oftentimes it–it might not even have been the weather, maybe because they’re staying inside more and all that dust accumulates and what not.  I stayed pretty–pretty healthy, to think that I messed up because I didn’t eat that great and that’s when I started feeling like, “I don’t feel like myself.”  So I know people say like, “Oh, does food really make that much of a difference?  And I could tell you, I–I was not–I’m not in my greatest shape, just in, you know, just in that stress off of a couple of weeks.  So, yeah, food makes a big difference.

Dr. Justin Marchegiani:  Absolutely.  I’ve been off a little bit with my exercise but I find diet is, you know, 80% of the game, just choosing some good movement patterns, adding some–some resistance in there, doing some good movements.  You don’t need too much once you’re at a high level to really maintain.

Baris Harvey:  Yeah, definitely.  So–and today, well, before I get to today’s podcast, what did you have for breakfast?

Dr. Justin Marchegiani:  Today was just 4 eggs, sunny side up and some–some butter and MCT in my coffee.  Today was pretty simple.  I’ve been doing a lot more collagen recently because to help, just kinda with hair and skin and just anti-aging and also to help with some of my joints.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  So I’ve been kinda just really rocking out the collagen.  I actually just got my organic acid test back so I’ve tweaked my supplement program a little bit to help improve my health and there’s some things on there, I think we’ll–we’ll talk about in today’s show regarding mood and neurotransmitter health.

Baris Harvey:  Yeah.  Now for the listeners out there, yeah, I remember we’re on a–me and Dr. Justin are on a 2-hour difference right now, so usually for my Friday I kinda, I might have been more relaxed when my–my day’s not always as busy so sometimes I don’t–I don’t wake up as early, so sometimes I usually just wake up and just hop on–hop on the call.  You know, compared before and I hop on the call, so I don’t always eat anything.  So I’ll tell you what I’m gonna eat after.

Dr. Justin Marchegiani:  Nice.

Baris Harvey:  So after the show, I’ll also have some eggs and then I’ll have some organic, you know, not a lot of ingredients because I think when I say sausage, somebody’s gonna think of like, “Oh, sausage, that’s not healthy,” but alright, if you go to the healthy food store, you’ll notice there’s high quality sausage out there and I just keep it simple like that and just, you know, I think so–I think, well, II do fine with dairy especially if it’s higher in fat, so sometimes I like putting in some organic sour cream, and I do fine with that.

Dr. Justin Marchegiani:  Nice.  Awesome.

Baris Harvey:  Yeah, so today’s podcast we’re gonna talk about fixing our mood and this is something that can be–can either–either be like sleep, it can be PMS, that’s something that’s almost joked about, and it–and–and people might joke about it but it–but it’s a real concern, a real matter.  And there are other things that, and–and we gotta be careful here because there’s a–there’s a gray area.  We mention things that might sound a little bit more psychological.  We wanna remember that, you know, we don’t wanna say that all drugs are bad or anything of that fashion.  We just have to be smart that there are some people with more severe cases that–that might need more treatment but you can be on the borderline with some of these things and maybe there’s some underlying things that you can fix yourself.  So if you have like a mild depression or like a mild–or even if you do have severe, there are still things you can fix, but just understand that, you know, also talk to your doctor about these things as well.  So, if you have like some depression issues or some obsessive overthinking, anxiety, today is a show for you, and make sure, you know, that you consume as much of this knowledge that you can and because when you’re mood is off, it–it kinda changes who you are.  And I’ve–I’ve noticed myself like get–not get enough sleep and become irritated and all of a sudden like, “That’s not me, I don’t wanna be mean to other people,” so-and I’m pretty sure you–you’ve had that every once in a while, Dr. Justin, where you just–you don’t get enough sleep and maybe ate something bad and all of a sudden someone’s like, “Whoa!  That’s not you.”  And you’re like, “Oh, I’m sorry, that’s totally not how I act.”

Dr. Justin Marchegiani:  Exactly.  So when we deal with these issues we have foundational principles, right?  These are things that we cannot ignore these if we wanna feel good and have a good mood.  So you kinda have already to it sleep.  Sleep is ridiculously important because sleep actually helps us have good sensitivity to blood sugar.  So what that means is they’ve have done studies where they took healthy college kids.  They cut their sleep in half to 4 hours a night.  After 1-2 weeks later, they were insulin-resistant, meaning the cells in their body were–the receptor sites were numb to sugar, to glucose, and they weren’t taking it into the cell properly and the glucose was accumulating in the blood creating free radical stress, right?  And free radical stress are like it’s basically when the body kinda comes in there and can damage the DNA, right?

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  So it’s when the body can chip away and–and chip away at the electrons essentially.  Ox–oxidation is nothing more than the loss of electrons and that creates damage to the DNA.  So we wanna really make sure that we have good stable blood sugar and the first way we do that is to getting to sleep on time ideally 10 to 10:30, definitely before midnight, that’s gonna be a great way to make sure our mood is dialed in.  That’s one, from a foundational perspective.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  Two, blood sugar.  So if you have thyroid issues or adrenal issues, we don’t wanna be skipping meals, having enough food that can last us 4-5 hours a day is gonna be huge–or sorry, 4 to 5-hour in-between meals, so having your breakfast within an hour of getting up, eating the right ratios of protein and fat and carbohydrates for you is very important, and you should go about 4-5 hours and you shouldn’t be starving at 4-5 hours.  So those are just some really key foundational principles.  Blood sugar and sleep.  You wanna add to that, Baris?

Baris Harvey:  Yeah, that’s some night we should always make sure that we have down at a basic borderline if you’re not.  If your blood sugar is off, that’s an easy way to get irritable and if you’re not sleeping enough, those are I guess basic foundational thing that you already mentioned so as long as people know that, “Hey, make sure you’re getting enough sleep.”  Those two, basically if those two things aren’t on point, any of these other stuff we’re gonna talk about is just minutia at that point, right?

Dr. Justin Marchegiani:  Exactly, and regarding all the blood sugar stuff, most people are kind of brainwashed regarding blood sugar.  “Oh, my blood sugar drops,” like “Eat a candy bar or something,” or like “Have some candy.”  Like that’s not what we’re talking about here.  So I use a lot of analogies and I think you do as well with your practice and with your patients.  But I always tell patients imagine you got a campfire in front of you, right?  You want that campfire to–you wanna ignite that fire, but you want it to stay lit for a while so you don’t get cold, right?

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  And just think of the heat from the energy is like–the heat from the fire is analogous to your energy throughout the day and in-between meals.  So for the most part, the logs in the fire are gonna be really important.  So the logs are like the protein and the fat.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  And by protein, we’re just gonna go out there with the assumption, organic, high quality, you know, grass-fed meat, chicken, fish, beef, skin on, good quality fats from like grass-fed butter, ghee, coconut oil, you know, tallow beef, things like that.  So that’s kinda already lumped in to when we say protein and fat, the quality is already built into that.  So that’s are like the logs in the fire and if anyone’s lit a fire before, they probably know they maybe used a little bit of kindling.  And some of that kindling–

Baris Harvey: Uh-hmm.

Dr. Justin Marchegiani:  May be some paper and that paper in real world terms may mean, maybe some low glycemic fruit, berries, things of that nature.  Or maybe eat some vegetables.  Maybe eat some vegetables like broccoli or spinach, right?  And then sometimes we have things like gasoline that we use in the fire and that maybe like sugar, refined sugar or even–

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  Alcohol.  So if you ever just like have like your match lit and you put a whole bunch of gasoline on it, it goes up and then out.

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  And that’s kind of analogous to how people’s moods are, right?  They go out, they’re like bouncing off the walls, feeling super good, and then they’re crashing with their head on their desk just a little while later.  So we wanna make sure when that fire’s there, maybe we have 80% to 90% good logs, and then we put maybe a little bit of paper in there, using the right carbohydrate, you know, for your metabolic needs.  If you’re working out that morning, you may put a sweet potato in there.  If you’re trying to lose weight or you’re trying to, you know, eat according to healthy thyroid and adrenal function, you may go lower carb in the morning and ramp up carbs later in the day, kinda like an adrenal reset diet where you go higher carbs at night when cortisol is lower and you maybe go lower carb during the day when cortisol’s higher.  So that’s kind of a good analogy there and just thinking you light that fire, right?  The logs are like the proteins and fats and maybe the kindling is like some of the carbohydrates and just choosing the right kindling that’s appropriate for your metabolism.

Baris Harvey:  Yeah, definitely.  So that sounds great.  You also did a podcast on blood sugar in the past as well, so I’m gonna advise all your guys out there to, you know, search that one up.  I can also put a–a link in there as well on that.  We also–we’d talked a lot about different supplements that you can take or–or foods that can help with–helping your blood sugar and what different cravings mean and how to–how to kind of fix these because yeah, low blood sugar, you’re–you’re gonna end up being stressed out and cranky and irritable and have a headache.  So, yeah–

Dr. Justin Marchegiani:  No good.

Baris Harvey:   Yeah, no good.  Alright, we mentioned making sure that our–our diet’s right and you know, avoiding the sweet foods and could there also be some specific foods that just might throw people off?  I know some people just don’t do good with caffeine.  Some people might be allergic to certain foods.  What are just some certain foods that are just like no-nos for people?

Dr. Justin Marchegiani:  Well, of course, we have foods like gluten.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  And for the most part I kinda reverse the effects on gluten where gluten is guilty until proven innocent.  Because there’s such a majority of people out there that will benefit from cutting gluten out.

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  The fact that gluten is a nutrient-poor food, it’s inflammatory, it doesn’t have the nutrients that we need, it can spike our blood sugar, it’s–can also create leaky guts, and then also it is highly refined with folic acid which a lot of people don’t have the MTHFR genes so then they convert folic acid–they–they can’t convert it and it’s actually can be pretty cancerous.  So there’s so many reason to cut out–

Baris Harvey:  And why and why not eat it versus–

Dr. Justin Marchegiani:  Yes.

Baris Harvey:  To eat it, right?

Dr. Justin Marchegiani:  So a lot of people are like, “Oh well, you know, you’re just being a zealot, you know, not everyone’s gluten-sensitive.”  In my experience, the majority are gluten-sensitive, so I air on the side of cutting it out and keeping it out, that I’m gonna help more people than I hurt from that perspective.  But from the other perspective, the foods you eat on a continuous basis should be nutrient-dense, low in toxins, and anti-inflammatory.  And gluten gets a–a failing grade for all of those category and then we add on the whole folic acid thing and the MTHFR SNP–we’ll save a podcast specific for methylation and MTHFR, but most people can’t covert whether they’re heterozygous MTHFR or homozygous, meaning one gene or two genes, they’re gonna have a hard time converting folic acid into active folate or MTHFR folate.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  So gluten’s gonna be a big way there.

Baris Harvey:  And any other foods you can think of that are inflammatory foods or anything–

Dr. Justin Marchegiani:  Well, anything, omega 6 fatty acids, refined vegetable oils, trans fats, refined sugars.  What sugars are gonna do–the reason why sugar’s so addicting is because when we spike up insulin because insulin gets spiked up because of sugar.  So insulin’s kinda there to pull all that sugar into the cells.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  And so for the first part of that when you’re eating some protein and a whole bunch of sugar, it’s gonna shuttle as much sugar into the cells and into the muscles.  What happens is 5-HTP, L-tryptophan and L-tyrosine tend to have an affinity to cross the blood brain barrier faster while all the other proteins are being shuttled into the muscle and into the cells.  So what happens is we get this huge rush of serotonin and dopamine being converted in the brain because L-tyrosine and 5-HTP, we’ll talk about this, but they are amino acids.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  And all amino acids–let me say it another way–all neurotransmitters are actually made–

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  From protein and amino acids.

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  So all that protein is, imagine a pearl necklace, right?

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  A pearl necklace is the protein and all of the pearls connected to the necklace, those are like amino acids, so a string of pearls together, each individual pearl being an amino acid and then the whole necklace as a–as a whole will be the protein.  So all those amino acids, they actually make up our neurotransmitters.  And neurotransmitters are the little cellular communicators that go in between neurons.  So like take a–kind of give you an analogy here–make a fist, make two fists.  A fist with your left hand and a first with your right hand, and kind of put your knuckles like they’re gonna touch each other right in front of your body, so your knuckles are meeting–

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  Right in front of your sternum and pull them apart just about an inch or two.  So your left knuckle will be like the presynaptic neuron, that’s where the action potential or the currents, the nerve connectivity flows down.  The space between–

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  Your left fist and your right fist is called the synaptic cleft or the pre–the pre-synaptic space.  That’s where a lot of the neurotransmitters accumulate and then–

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  The right hand or the right fist will be the post-synaptic neurons.  So again, the currents flowing from the left fist then we have the neurotransmitter, the pre-synaptic cleft that space there where the neurotransmitters accumulate and the neurotransmitters are like a bridge, a bridge of action potential from the left fist to the right fist.  So we have the pre, which is the one leading up to it.  We have the space, which is the–the–the space in between there where the neurotransmitters accumulate.  And then we have the post-synaptic neuron which is the right fist.  And all of these neurotransmitters actually accumulate in between the pre and post-synaptic neuron.  And these neurotransmitters allow us to feel good, so we have serotonin which allows us to feel kinda happy.  We have dopamine that allows us to feel the “I love you” feeling.  It’s that when we get when we’re in love or what we get when we’re eating a bunch of sugar, we have GABA which can relax us, so these are really important neurotransmitters that allow us to feel good.  Do you wanna elaborate on that, Baris, or break it down a little more?

Baris Harvey:  Yeah, I–I think the analogy you used was great, you know, like either–you wrote down some good notes when you were taking anatomy or you had a great anatomy teacher, like I this–I went ahead and did it myself with the two hands and like that’s almost exactly how like it looks, it’s–it’s–has little bulb at the ends–

Dr. Justin Marchegiani:  Yeah.

Baris Harvey:  And your spinning neurons and that’s where–and so–so basically for people to know we are bioelectrical-chemical beings so there are electric surges that get sent to other cells, our–our neuro cells have these little–actually, you know, just where your–this little space, these little gaps in which their communication that actually happens and then, you know, they send the chemicals and depending on if they can’t absorb it or reabsorb that’s where, you know, problems are gonna happen, right?

Dr. Justin Marchegiani:  Exactly.

Baris Harvey:  So like if someone’s either overstimulated or they can’t reabsorb something appropriate, that’s when, you know, for an example, if someone does cocaine often.  Dopamine is–is the one–the–is gonna shoot out very often, right?  And it’s in–it keeps it in that rather than getting reabsorbed, it keeps it in that synaptic cleft.

Dr. Justin Marchegiani:  Exactly.

Baris Harvey:  And it’s overstimulated and that’s why people feel amazing, I hear.  I’ve never done it before, but I hear people feel amazing and that’s probably why it–it’s extremely addictive.  Not to the same level but that kinda happens with sugar as well, so I’m not saying that sugar is cocaine but there is a similar mechanism and that’s just why, you know, sometimes your sweet tooth wins the battle when it comes to your willpower.  So–

Dr. Justin Marchegiani:  Well, also from that standpoint, there had been studies where they fed rats–the rats had to chance to choose cocaine or Oreo cookies and they found the rats were choosing the Oreo cookies over the–the cocaine and they found the same areas on the brain that were being lit up with the cocaine use were being lit up by the Oreo cookie use.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  So at the same standpoint, you know, one is just, you know, more societally accepted than the other, right?  You know–

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  We don’t look too, you know, friendly on, you know, drug abusers in society.

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  In my opinion, we should treat them like severe obese people that just can’t–that have no self-control.  It should be looked at between that because people aren’t really getting helped.  Throwing people that are like just neurontally damaged in jail.

Baris Harvey:  Damaged in jail.  Yeah.

Dr. Justin Marchegiani:  It’s just not–it’s not fixing the problem and they come out as violent criminals.  So we don’t do that with severe obese people that just can’t–can’t stop eating because that’s like a societally accepted thing.  But what happens is the same parts of the brain are being lit up.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  And what we’re doing with food, what we’re doing with dopamine–excuse me, what we’re doing with cocaine to increase dopamine, what we’re doing with SSRIs or all these drugs, they have one thing in common.  And that is they are changing the location of where these neurotransmitters are.  So again, left fist, right fist, the in between space that’s where the neurotransmitters accumulate.  What they’re doing is, they’re taking all the neurotransmitters that are stored up in this left fist and they’re bringing it out into the middle.  Now here’s where it’s interesting.  When we change the location, when we pull these neurotransmitters out of that left fist and we put it in between in the middle, we get that really good feeling.  But the problem is, the longer they stay outside of the fist and in this space, they break down faster.

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  So let me say that again, most habits that are drug-induced or sugar-induced, or let’s say it’s like CrossFit extreme exercise-induced or like jumping out of airplanes, any type of like crazy addiction that that’s bringing you negative results in your life, that’s just changing the neurotransmitter location.  And the more you rely on changing the location, the faster these neurochemicals break down, we set you up for long-term destruction because then the amount of neurochemicals that are there drop and those neurochemicals can’t carry the signal from the left fist to the right fist or for the science junkies out there, the pre-synaptic neuron to the post-synaptic neuron.  And that’s important so in–in functional medicine world, we wanna work on things that don’t just change location but actually build up the amount of neurotransmitter in that location.

Baris Harvey:  Uh-hmm.  Because that’s when you start to getting–that’s where it starts to get insensitive, right?  Or–or it’s not communicating the signal strong enough and all of a sudden what used to be, you know, super powerful now you–now the only way you get happy is  with cocaine because nothing is strong enough to–to–to have that feeling, right?

Dr. Justin Marchegiani:  Exactly.  It’s like those Einstein balls.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  So like if you’ve ever seen them in the museum or on like, you know, cooler places there like the little balls that like swing and like hit a ball and the other ball kinda goes up the exact same place and it kinda swings back and forth and hits?

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  So if you’re on Google Image, just type in Einstein balls and you know what I’m talking about.  But imagine that first ball hitting and that second ball barely moving.  Like that’s what happens if there’s not enough neurotransmitter in between that left fist or that right fist and most of the drugs, let’s just break down a few drugs like Celexa or Lexapro, you know, these are selective serotonin, that means they’re working on increasing serotonin in the synapse, reuptake inhibitor, that means it’s blocking the body’s ability to pull it back up into the pre-synaptic neuron or that left fist.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  And then you look at other drugs like Wellbutrin, that’s gonna be more of a dopamine inhibitor and there are other drugs for migraines that are norepinephrine inhibitors.  So a lot of these drugs work on just blocking the uptake which in essence changes the location of where these chemicals are.

Baris Harvey:  Uh-hmm.  Yeah, definitely.  And yeah, and–and with our–our brain chemicals, too.  There–there are two different kinds and dopamine being so awesome and so powerful, it kinda fits in both categories but, you know, the inhibitory neurotransmitters and the excitatory neurotransmitters, so making sure that we’re stimulating and the right ones are firing in the brain at a certain time like you don’t–you don’t need norepinephrine firing off at midnight when you’re trying to go to sleep unless, you know, someone’s breaking into the house, and yeah, that would totally–but unless something, you know, is bad happening, you need to–I guess and that can be an–an another way to help with some of our mood issues as–as I guess that’s back to our foundational start we talked about the blood sugar and getting good sleep but relaxation and exercise, you know, exercising is a healthy way to one, get your body moving, get the hormones pushing the right direction but also it might not always feel good when you’re doing it if it’s hard but you feel really good after when you get really good sen–sensation and you’re kinda fixing some of your neurotransmitters but also making sure that regular relaxation, you know, if you’re stressed out all the time you’d–if you’re in a crisis we know that we feel–we don’t feel right, but if it’s–if it’s daily, that’s chronic, and we’re letting maybe that person at work or relationship hinder how we feel in our relaxation and you go to sleep every night not feeling well, you kinda create this vicious cycle. Well, now you can’t, you know, maybe that–that’s causing some longer term depression or it can even cause like other problems.

Dr. Justin Marchegiani:  Those are some really good points, Baris.  So, Baris, let’s talk about some things we can do from a supplemental perspective.

Baris Harvey:  Yeah, that’d be awesome and real–real quick, too.  Just for so some resources that people might wanna know about right before we get into the supplements that I know you’re gonna, as well people the mute them–if I can speak English, The Mood–The Mood Cure by Julia Ross.

Dr. Justin Marchegiani:  Julia Ross, right.

Baris Harvey:  And also Change Your Brain, Change Your Body by Dr.–

Dr. Justin Marchegiani:  Daniel Amen.

Baris Harvey:  Dr. Amen.  Yeah.

Dr. Justin Marchegiani:  Yup.

Baris Harvey:  So those are other great resources, but you go ahead and–and knock some supplement or advice to our listeners.

Dr. Justin Marchegiani:  Absolutely, very good.  So it really depends on what the problem is because a lot of hormones actually–

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  Are natural kind of reuptake inhibitors.  So for instance, females especially if they have PMS or any mood issues or disruption in their cycle for instance, you really wanna make sure the hormones and the adrenals are working.  So if a woman has PMS or has issues with progesterone in the second half of the cycle which female hormone symptoms have to do with the combination of estrogen dominance which has to do with progesterone being lower than its ideal ratio in relation to estrogen.  Typically there should be like a 23 to 25 time more amount of progesterone to estrogen and when it drops–when it drops in that ratio, we can start having symptoms.  We can start having excessive bleeding.  We can start having moodiness.  We can start having breast tenderness.  So all of these things can easily be fixed by getting the adrenals and the female hormones working again.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  Now on that note, we talked about blood sugar and sleep earlier if you don’t make those changes, the sleep and blood sugar and stuff, you will never ever, ever and I hate using absolutes, but for the most part it’s just true and I think you would agree–if you don’t get the blood sugar and the sleep on track, you will never be able to get the hormones on track no matter how fancy a supplement program we make.

Baris Harvey:  Yeah, definitely.  Or you can’t sleep 4 hours a night and eat candy all the time and then take a pill.  It’s not gonna work that way.

Dr. Justin Marchegiani:  Exactly.  So at most females for instance, we really wanna make sure that we get the hormones dialed in and the adrenals are gonna be an important component of that.  So that’s gonna be one of the most important parts right there.  And also if a woman has low progesterone that second half of the cycle, they’re gonna be excessively.  When they bleed excessively, then they’re gonna be low on iron and if they’re low on iron, they’re not gonna be able to carry oxygen properly which then–we’re not gonna be able to have aerobic metabolism when we’re burning fat and oxygen for fuel efficiently and then iron’s needed to make thyroid hormone as well.  So it’s like this vicious cycle when female hormones get off, all of these other problems start to occur.

Baris Harvey:  Uh-hmm.  Yeah, definitely.  And–and I know, you know, a lot about this topic and the thyroid is gonna have–have in accord with our energy and our mood, right?

Dr. Justin Marchegiani:  Exactly.

Baris Harvey:  You feel lethargic and you’re probably not the happiest person in the world.

Dr. Justin Marchegiani:  Exactly.  So that kinda leads us into the next thing, we have kind of our hormone centers.  We have ATF for females and ATM for males, meaning–

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  Adrenals, thyroid, male hormones or adrenals, thyroid, and female hormones.  And we wanna make sure those are balanced at some level and by balance, we can kinda push the female hormones or the thyroid back into the right place but if there are other issues pulling it out, we really have to make sure the root causes are–are being addressed.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  So on that notes–on that note, looking at thyroid is important.  They did a study where a third of the people who are depressed, they found had low thyroid function and when they just got their thyroid fixed, depression was gone.  So a lot of mood issues can be fixed just by getting the thyroids or getting the adrenals or getting the female hormones working better.  So that’s why you really don’t want to have like a symptom-based approach.  You really want a systems-based–based approach because if you look at the systems that are out of balance and you just start nudging them back into balance and you make the diet and lifestyle and sleep changes along with it, half of those people with mood issues are gonna be fixed off the bat.

Baris Harvey:  Yeah, okay.  A real big one that we can all–and I–I think we talked about–we might have talked about this before so I’m gonna go ahead and–and look it up and link it if–if necessary, but PMS that can really throw off some–someone and I know one thing that I notice a lot with the women in my life that have had that, they also sometimes have heavy cycles and end up being anemic or need to watch their iron because iron totally make an interplay with like PMS or what are some other things that a woman can do if she has PMS?

Dr. Justin Marchegiani:  So off the bat–off the bat there with PMS, you really want to get to the root cause–

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  So the blood sugar and the sleep is kinda really important, the adrenals are really important.  With some patients depending on their progesterone, we’ll use a cyclical augmentation program where we actually modulate and give small amounts of progesterone during the second half of the cycle to really get the progesterone levels back on track.

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  Now once that kinda gets on track, we also see that the bleeding becomes less and we can even use herbs such as Chaste tree or Vitex agnus.  We can even use estrogen-modulating herbs like Dong quai or black cohosh and such to really help kind of modulate those things, and remember these hormones actually have an effect on the reuptake of neurochemicals.  So we kinda already talked about how when we block the reuptake of neurochemicals that may be a bad thing–

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  But if we’re blocking the reuptake by just restoring normal physiology that may not be necessarily be a bad thing because we’re just trying to push the body back into balance.  We’re not trying to make it–we’re not trying to use hormones or supplements like a drug, we’re trying to use them to push normal physiology back and if–if those hormones help and provide enough blocking activation to make the person feel better, well, the issue may have just been hormonal imbalance driving that neurochemical imbalance and that neurochemical imbalance is restored to normal function.  So maybe it’s just the hormones that are actually causing the reuptake issue.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  Like monoamine oxidase or MAO is a specific drug out there.  Now if we can do something via natural means, it’s always better because natural means tend to have more, how should I say it?  They have more homeostatic mechanisms involved.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  So there’s more sensors, if you will, to make sure things are working properly.  When we use the drug, there’s just one objection.  It’s to block–

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  An enzyme or to inhibit some type of pathway and there aren’t quite as many feedbacks letting things to know that, you know, we’re imbalanced.

Baris Harvey:  Yeah, I hear this would be like fix even one specific thing but if the body doesn’t–

Dr. Justin Marchegiani:  They whack ‘em all.

Baris Harvey:  Yeah, exactly.

Dr. Justin Marchegiani:  Whack ‘em all.

Baris Harvey: Your body is like–

Dr. Justin Marchegiani:  You pop one down and another one comes up.

Baris Harvey:  Yeah, like “Okay, why did that happen?”  We don’t know.  Yeah.

Dr. Justin Marchegiani:  Exactly.

Baris Harvey:  Whereas, you know, you eat a food and there are so many different chemicals and signals in there and helps boost certain area but it also just like works in rhythm with your own body.

Dr. Justin Marchegiani:  Exactly.

Baris Harvey:  Right, definitely.

Dr. Justin Marchegiani:  So the next perspective is we can actually give amino acids to help–

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  With boosting up the location of these neurotransmitters. So for instance we have 5-HTP which is a precursor to serotonin and we have L-tyrosine which is a precursor to dopamine.  Now when we do this with a lot of patients, I–I recommend using 5-HTP over L-tryptophan because there’s an enzymatic regulation where you only can make so much serotonin from L-tryptophan.  With some people that may have damage or made them in higher amounts than normal, you wanna use 5-HTP because you’re not gonna have that capacitor or that–what do they call it when–when it prevents it from getting higher or they have it in cars for instance that prevent the engine from going too hot?  I forget the term.  It will come to me in a minute there, but it’s–it’s basically preventing the transmission and the conversion of serotonin.  But if you use 5-HTP–I’m sorry that term is governor.  If you have a governor on something–

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  The governor prevents it from going too high.  So the governor is taken off when you give 5-HTP so you can actually get higher levels of serotonin than if you just gave L-tryptophan instead.  So I like 5-HTP.  The key is we have to give it with B6, that’s really important.  We need B6 to actually help convert 5-HTP to serotonin and I always give for the most part starting out 5-HTP and L-tyrosine in a balanced formula of 10:1 so 10 times more L-tyrosine than 5-HTP.  So if we’re dealing with 100 units of 5-HTP, we wanna have a thousand units or 1,000 mg of L-tyrosine.  And that’s important because the same enzymes that metabolize 5-HTP which is the amino acid decarboxylase enzyme, that amino acid is the same one that metabolizes L-tyrosine.  So if we’re stimulating this enzyme to–to break down 5-HTP and we’re giving more 5-HTP and this enzyme’s upregulated and we don’t have an additional amount of L-tyrosine there along with it, we can start creating deficiency because of us upregulating that enzyme.  So you always wanna give this long-term, right?  More than a month or two.  You wanna give them in conjunction and ideally with B6 and ideally being on other good multivitamin with B12 and folate and all the other nutrients as kinda there as a blanket to make sure that there’s no nutrients that are missing for neurotransmitter metabolism.

Baris Harvey:  Yeah, definitely.  That sounds good.  And I know that that some people will do really good with 5-HTP like you mentioned and whether that be in a smaller or a larger dose of L-tryptophan, but also there are some people that do–do really well with a GABA.  The gamma-aminobutyric acid–

Dr. Justin Marchegiani:  Right.

Baris Harvey:  Which is our–that natural tranquilizer like a chemical which kinda relaxes us and loosens us up kinda and–and I know I’ve used before in the past as well.  So I–I’ve actually taken–I think it’s Source Naturals, but they had this Theanine Serene which have like–had a little bit of GABA and theanine and I think some magnesium and some other natural herbs, those are really nice.  I forget the formula off the top of my head.  But tell us a little bit about GABA and how that can help you sleep.

Dr. Justin Marchegiani:  So GABA can be helpful, there’s a–this is kind of a controversial school of thought so–

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  I’m a big fan of Marty Hinz.  He does a lot of research on neurotransmitters.  Basically, he’s like the catch-all guy that neurotransmitters can fix everything.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  And in the functional medicine world, we wanna be careful of absolutes.  I think neurotransmitters can be a real powerful tool in your tool belt to address any type of mood-related issue.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  But I think we also need a good functional medicine model where we don’t, you know, throw the baby out with the bathwater.  So I think it’s important.  So without the GABA, if you look at Marty Hinz’s type of perspective, he says that dopamine and se–serotonin are gonna be the master regulators of GABA.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  Meaning that if we work on dopamine and serotonin, the GABA kind of takes care–takes care of itself if you will.  Now on that note, I’ve seen patients that do well with GABA.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  But on the same standpoint, you talk to other people like people that are in Dr. Kharrazian’s camp, they’ll say that GABA cannot cross the blood brain barrier, it is too big, it is too large, the research paper say this, and the only reason why you’d have an effect with GABA is because you have a leaky gut/leaky brain–

Baris Harvey:  Leaky brain.  Uh-hmm.

Dr. Justin Marchegiani:  And then the GABA is passing in there and having that type of an effect.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  Now personally myself, GABA does nothing to me.

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  I have a lot of patients where it’s done nothing and I have had some where they swear by it.  So is that true or is it not?  Well, it’s hard to say.  And with so many people–

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  Having leaky guts, maybe there’s more people out there that have leaky brains than we think–

Baris Harvey:  Right.

Dr. Justin Marchegiani:  They actually benefit from GABA.  But I like Hinz’s school of thought that we really wanna deal with the master neurotransmitters because a lot of times when we deal with the masters, everything kinda gets taken–

Baris Harvey:  Taken care of.

Dr. Justin Marchegiani:  And can put back in balance, taken care of, exactly.

Baris Harvey:  Yeah, definitely.  Sounds good.  That sounds good.  And I know that there’s–there’s, you know, a lot of stuff when it comes to all these things and–and we talked about the making sure we get the basic functional–make sure you get your sleep, make sure you relax, make sure you have a healthy mood, and your blood sugar’s regulated.  I mean some–some other functional stuff, you know, anti-inflammatory diet, you know, making sure your vitamin D levels are in check, and you know, you’re taking your fish oil and–and there’s a lot of specifics.  So for–for people that might have a specific question, I urge you to go to beyondwellnessradio.com and we have a tab that says Questions.  You can leave us a question.  You can click on the tab that says Just In Health and Contact Dr. Justin for a one-on-one consultation if you wanna look further into this, you can also contact me as well.  So yeah, you wanna go ahead and–and–and add–and add some?

Dr. Justin Marchegiani:  Yeah, absolutely.  So we also look at some of the neurotransmitter conversion with dopamine and according to Dr. Dan Kalish who has done thousands of neurotransmitter testing with DBS Labs, he’s found that most people tend to be dopamine dominant–or sorry–I’m sorry dopamine­-deficient, meaning they actually need more dopamine.  So when we look at dopamine, we were thinking L-tyrosine.  That’s gonna really improve dopamine conversion.  Now if we’re doing this whole 10:1 ratio, that’s a good starting point, right?  Maybe 100 mg of 5-HTP to 1,000 of L-tyrosine, maybe bringing that up to 300 mg 5-HTP to 3,000 L-tyrosine, that’s a good place.  We also need sulfur-based amino acids for healthy conversion of dopamine.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  Okay, what that means is this.  We have dopamine that gets converted from L-tyrosine, and that dopamine that goes from L-DOPA to dopamine and then it goes to norepinephrine.  And norepinephrine to have that conversion from dopamine to norepinephrine, we need some certain nutrients there, alright?

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  So norepinephrine to go to epinephrine needs sulfur-based amino acids and there’s two main ones that you could use.  SAMe or methionine or cysteine.  So cysteine’s a pretty rare one.  Dr. Hinz uses cysteine.  I’d use little–I use L-methionine instead because it’s a little bit more cost-effective than SAMe.  SAMe is pretty expensive.

Baris Harvey:  Yeah, it is.

Dr. Justin Marchegiani:  So I’ll use L-methionine with patients instead and L-methionine will really help with that conversion of norepinephrine to epinephrine, right?

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  So one more time, right?  We need dopamine to go to L-DOPA.  L-DOPA then goes to norepinephrine and then to get norepinephrine to epinephrine, we need the sulfur-based amino acids and that’s where SAMe, cysteine, or L-methionine.  And I urge you not to use NAC.  The research had been kind of on the fence about this, but most people just say, “Hey, NAC is not gonna be what you need to make that conversion.”

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  I think you’re just better off from a cost-effective perspective, if you could go with the methionine anywhere between 1,500 mg to 3–3 g or 3,000 mg is a good way to go.

Baris Harvey:  And the–so you–you probably recommend not using like L-DOPA itself as a supplement using the precursors instead, correct?

Dr. Justin Marchegiani:  So regarding using pure L-DOPA, it’s possible there are things such as mucuna pruriens or velvet bean where you can extract L-DOPA directly from that which is actual L-DOPA.  Now that’s really interesting.  I’ve had an experience using L-DOPA.  I don’t recommend using that unless you are working with a practitioner.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  I used it and I literally felt like–

Baris Harvey:  Literally, too strong.

Dr. Justin Marchegiani:  Yeah, I felt like I was incredibly spacey, felt like I was walking around drunk, like it was a terrible experience and I’m like–

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  Alright I’m gonna do this–this was like 5 or 6 years ago when I was like in the middle of finals–

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  And studying for a really big exam and I’m like, “I’m gonna boost up dopamine because dopamine helps with focus.”  And I just overdid it and it was terrible because I couldn’t study the whole day because I felt so spacey.  I felt like I was drunk.

Baris Harvey:  Uh-hmm.

Dr. Justin Marchegiani:  So I said, “Alright, this is a lesson learned.”  So I strongly recommend you do not use L-DOPA unless you are working with a trained functional medicine physician.

Baris Harvey:  Uh-hmm.  Right.  I know that–I forgot when I first saw that  and I-I’ve never used it myself so I can’t really give my 2 cents on it but I remember, it’s gonna probably like a–a long time ago when I was just looking for supplement–like workout supplements and those like supposed to help with boosting testosterone and what not, and that’s when I first–but after researching it, I mean I might do a little bit of that but it’s more so with the–with the dopamine-like response.  Yeah, you-you know the opposite like effect, gotta be careful with that, what you supplement with.

Dr. Justin Marchegiani:  Exactly and this whole sulfur-based amino acid cascade adrenal fatigue, right?  Where we’re hyper secreting or maybe it’s fatigue where our cortisol’s actually bottomed out, we’re also gonna be kinda whipping the tired horse of adrenal or norepinephrine to epinephrine, so that’s gonna be low as well.  So that’s why adrenal fatigue is really important to helping to fix this whole pathway.

Baris Harvey:  Yeah, definitely.

Dr. Justin Marchegiani:  So I think a good starting dose for anyone here that says, “Alright, well, what–I wanna use some of these sulfur amino acids.  I wanna use some of these neurotransmitter supports.”  I think a safe dose would be 300 mg of 5-HTP followed with 3,000 mg of L-tyrosine with some sulfur-based amino acids, anywhere between 1500 to 3 grand of L-methionine will be a really good starting point.  And just to make sure the 5-HTP you’re getting has B6 in it and make sure you’re on a high quality multivitamin with B12 and activated MTHFR folate and if you need support with this, feel free and you can reach out to either Baris or myself because we do this stuff with patients every day.

Baris Harvey:  Definitely make a part 2 to this because–

Dr. Justin Marchegiani:  Yes.

Baris Harvey:  I know, I mean we could so long ahead of this stuff and I–I think we got a good foundation here.

Dr. Justin Marchegiani:  Yes.

Baris Harvey:  We got some things for people with irritability.  I know like myself and also like, I know mentioned in the beginning like anxiety and some of the overthinking like stuff.  We’re gonna make a part 2 for you and we’re gonna, you know, go into the hormones, estrogen, and the different supplements and neurotransmitters to help you with anxiety and mood and that as well.  So kinda like you had the depression on one side and then the overthinking on the other side and we’ll get to that one as well.  But again, go to beyondwellnessradio.com, go to Sign Up to the Newsletter.  You know, make sure that you won’t miss part 2 and you’ll get it right in your inbox.

Dr. Justin Marchegiani:  Well, we’re gonna really work on increasing the frequency of the podcast.  We’re gonna try to do 1 a week to really kind of get everyone’s brain candy addiction in for the week hopefully.

Baris Harvey:  Yeah.

Dr. Justin Marchegiani:  And if you guys got any feedback or have any feedback on show tips or topics you want addressed, feel free and reach out beyondwellnessradio.com and I think it’s question, slash question, and you can speak your question to us or you can drop us a line and we’ll be more than willing to, you know, listen to what people wants and–want and create show topics based on the needs of our listeners.

 

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