The Benefits of Collagen and Glycine on Your Health | Podcast #322
Collagen is rich in numbers in our bodies. It is an essential part of connective tissues that make up our tendons, cartilages, and muscles. Also, it functions to give fair skin structure, smooth hair, healthy nails, and bone strength.
On the other hand, glycine is an amino acid that your body utilizes to create proteins. It is also responsible for maintaining the connective tissues and making other substances, such as hormones and enzymes.
Dr. J and Evan Brand emphasized that glycine and collagen provide outstanding health benefits. Our body needs glycine to make essential compounds such as glutathione, creatine, and collagen. Also, collagen helps promote muscle mass, relieve joint pain, and reduces wrinkles and skin dryness.
Dr. Justin Marchegiani
In this episode, we cover:
0:44 Glycine Benefits
7:20 Fixing Root Causes
10:40 Natural Supplements from Food
Dr. Justin Marchegiani: And we are live. It’s Dr. J here in the house with Evan Brand. Evan, how are we doing today man? What’s going on?
Evan Brand: I’m doing good. I’m feeling better. I don’t think I even told you about this off the air. But I had a bat house on the side of my house.
Dr. Justin Marchegiani: A bat house?
Evan Brand: Yeah, bat house. Yeah, to try to get to try to get some bats to basically, you know, take take residents there. So they would eat all of our mosquitoes. And they never came. And I was up on the ladder. I don’t know, this may be two months ago now. And I was up on the ladder. And I was unscrewing the bat house from the house. And as soon as I did that, I noticed it was a wasp nest in there. And as soon as the, as soon as I saw that, a wasp landed on my hand. And last time I got stung, it hurts super bad. And so I wasn’t thinking straight, I thought, okay, there’s a wasp on my hand, I’m gonna get stung, it’s gonna hurt, I might shake my hand and fall backwards off the ladder, this is really bad. So I just turned around and just jumped. And it was probably not crazy high, but maybe eight feet up. And I just jumped and just tried to like, you know, cushion my fall as much as I could and kind of roll after I landed on the grass. But ever since then, man, I’ve had a little bit of some cervical, I probably need to see a chiropractor. I haven’t yet but I’ve had like some cervical tightness. And if I sleep the wrong way, it like flares up the cervical tightness. And so I’ve been using some herbal anti inflammatories and nutrients that we can dive into to help me. But I wanted to tell you that and see if you had any other suggestions of things I should be doing.
Dr. Justin Marchegiani: That’s really great. Yeah, so we’re going to be talking all about inflammation. And we’ll be talking about natural herbal support to kind of help her natural functional medicine support to help kind of reduce that inflammation. Now, structurally, in your situation, there’s probably some level of inflammation directly to that area. So some level of soft tissue, whether it’s active release technique, or myofascial just to kind of help with that tissue. Because when it gets strained or damaged or inflamed like that, it can get a little bit fibrotic, you can get some scar tissue, it can maybe lose some blood supply and oxygenation. So getting some good movement in that tissue to kind of help with oxygenation, make it more pliable, helps making sure those joints are moving well. So really good chiropractic adjustments through there to make sure everything is moving well, alignments, good. So those are the first things out of the gates that I’d be pursuing. Outside of, you know, just some good soft tissue support in your own like a good massage guns helpful just kind of day in day out. And then seeing good massage therapists, maybe some red light to kind of reduce inflammation, too. I think that’s great out of the gates. And of course, you know, we can kind of go into all of the different natural anti inflammatory, inflammatory support that we use typically in practice, and we’ll talk about what what you’re using already as well.
Evan Brand: Yeah, I appreciate it. I need to get back in touch with my myofascial lady. I just haven’t reached out to her yet. But I think she left town for a while. So she’s still around. I should probably try. I just got fearful I thought, Oh, god, what did I do to my spine? Am I screwed forever? You know, you hear about these people having like car wrecks. And you know, my wife used to work in a chiropractor’s office, and she would see people that were injured from 20 years ago. And I’m like, ah, why, like, surely it doesn’t have to be that way. And I think we have some good strategies that can definitely shorten the recovery timeline. Let me just talk about the topical aspect first. This one thing’s been very beneficial. It is a company called Ned. Hello, Ned is their company. And they actually just send it to me like a year ago, just as like a free Hey, we want you to sell our products. Here’s some free stuff to try out kind of thing. But I loved it so much. I bought more of it, but it’s called a body butter. And it’s just loaded with CBD oil and frankincense and a bunch of other essential oils. It has Arnica in there. So this is just a topical body butter. And I tell you, if I put that stuff on, it’s a significantly reduced pain. And my range of motion is almost 100% if I’m using that topically, so CBD Arnica frankincense, you know, something like that a good blend, or if you like by that body butter, that might be a good option topically.
Dr. Justin Marchegiani: I like that. That makes a lot of sense. So out of the gates, what’s the first thing so more than likely you get some kind of a mini whiplash? I’m guessing you kind of fell more into flexion. Right?
Evan Brand: Yeah, yeah.
Dr. Justin Marchegiani: So you probably had a little whiplash because you probably went forward and then your body had to like kind of seize up to kind of stuff that forward flexion and so it probably just strained you probably had a little spray sprain strain in those back ligaments in the neck. And so getting some good soft tissue out back there will help making sure that joints are moving appropriately will help the problem with like ligamentous tissue, it’s more a vascular, right, you don’t get great blood supply. Or like if you strain your muscle like a muscle belly issue, right, it’s going to heal a lot faster because that tissue is just more vascular, it’s got a lot more blood flow. So anytime you have a vascular tissue, you really need good soft tissue support to really help break down and break down fiber optic tissue, scar tissue and then help that will improve oxygenation and that will improve blood flow. And of course, you know, soft tissue and or red light therapy are all going to be amazing things to really work on the on the blood flow and the inflammation reduction aspects. So that’s good out of the gates. And of course like my good thing in my line, we use something called curcumin supreme. Which is a liposomal curcumin, I like that. I think that’s excellent because it has natural anti inflammatory pathway. So like the big inflammatory pathways that you’re going to see a lot of the medication use are going to be the Cox pathways right cyclo oxygenase pathways. And so like cyclooxygenase, two and cyclooxygenase one are going to be some of the big ones right? Now we can do natural herbs to kind of help produce Cox one and Cox two. So Cox one typically will be reduced by things like aspirin or n sets the problem with these things that can be a little bit more irritating to the liver into the gut. So maybe acutely, it’s okay, but chronically not the best, right? And then we have Cox two as well which these were like the old fashioned, like Vioxx drugs, remember, those, like 15 years ago, caused a lot of stroke and heart issues. Those are like our Cox two pathways. So Cox one and Cox two are some pretty good ones, that major pathways. And of course, we have like our prostaglandin e two, which is an inflammatory pathway as well. And prostaglandin e two is what drives constriction. And it’s what causes more platelets and more stickiness to happen. And so we want to work on reducing some of those pathway. So we want to knock down prostaglandin e two, what’s the best way to do that? Well, high dose fish oil or fish oil in general, of course up a really good whole food, pasture fed kind of paleo templates, it’d be great. And you’re going to reduce a lot of inflammation coming from conventional meats. Again, healthy grass fed pasture fed meats better, right? Less arachidonic acid, which feeds that PG net prostaglandin to pathway, of course, keeping the insulin and the grains and the refined sugar, all that crap in check, all of that inflammation feeds these Cox two and Cox one. pathways, right. And so we want to inhibit those pathways, we want to block them. So more Cox one, Cox two, the more inflammation is going down those pathways. So all the dietary crap sets the table, like my analogy is, imagine you walk into a kitchen and the gas is on the burner. Okay, let’s say it’s been on for a couple hours you smell it? Well, let’s say you pull out your lighter, right? Just a little spark, boom, how’s it gonna explode? Okay, but if you did it without the gas there, no explosion? Well, it’s the same thing. If you have the gasoline going, that’s a systemic inflammation from all of these things we chatted about, that allows the little spark of an injury like that, to set off this whole inflammatory cascade, that’s going to be a lot more, let’s just say amplified in the wrong direction, if you will.
Evan Brand: Yeah, that’s, that’s a great analogy. So let’s kind of spotlight some of the the key ingredients that we use here. Now some of these we can provide to our clients and to me personally in blends, and then some of them we can do in isolation. So I think the the best one or kind of the best combo for me is really some of the enzymes and then plus tumeric and the boswellia I think that’s been kind of my game changer because I noticed that when I added some extra serapeptodase into my system, I have a blend, I’m using the has some in there, but when I added extra serapeptodase, and also some lambro kinase, my issues, definitely, I would say I felt definitely more mobile, like I have more blood flow. And then of course, my hands and feet were warming up too. So I just know from like a circulation standpoint, that that’s also helping and then we know that tumeric has like an anti coagulating ability. So whether it’s like a tumeric tea or like you mentioned a life was almost a product or even just like a standardized curcuminoid product, something like that is going to be awesome.
Dr. Justin Marchegiani: Yeah, I like it. So if we kind of break things down by Cox one, Cox two, there’s also the locks pathway that’s like the the leuco trying pathway or the light bo oxygenase pathway. Alright, so lipo oxygenase versus cyclo oxygenase. These are both going to be inflammatory pathways. So if we start with like the Cox, one pathways, things like ginger are also going to be very helpful in that. So ginger is really good. Excellent. You can also do things like you mentioned lumberg kinase, or serrapeptase, that’s gonna just sit in your bloodstream, you’re taking it away from food, it’s not like a digestive enzyme. And that’s going to help hit all these inflammatory chemicals that are in the bloodstream, it’s going to start breaking them down and digesting them. And we already talked about the fact that we have a lot of platelet aggregation. So what that means is over time, those platelets are going to increase scar tissue and in decreased blood flow. So what are the enzymes are going to do is they’re going to break up those platelets isn’t help improve blood flow, improve oxygenation and improve nutrition. So and it’s also going to decrease scar tissue formation. So part of the enzymes are helping blood flow. They’re reducing. They’re increasing oxygenation, and they’re reducing scar tissue so then it helps a lot of the other nutrients also work better. So we already talked about like, some of the Cox one stuff is going to be ginger. We talked about that already. Some of the Cox two things are going to be things like curcumin, lipids, omo curcumin, and my line I have one called Curcumin Supreme, which is a really good one. And then you already mentioned a couple things earlier like Frankincense or boswellia. That’s also going to be another cyclo oxygenase ACE inhibitor and the thing I like about boswellia or frankincense, it’s the same thing. By the way, guys, frankincense is the essential oil version of that frankincense, you can kind of put topically on it. And then you can also take boswellia internally, so you can kind of hit it from both ends, which is really good.
Evan Brand: Yeah, also omegas, I am boosting up my omegas, I’m doing about five grams per day of pure omega, that’s my formula. It’s a triglyceride form of omega as it works amazing. And then also, I’m doing extra course attend, just to really help you know, I’ve had some histamine issues after getting exposed to mold. So for me, I do course attend with an enzyme, there’s a special enzyme we use, it’s a course it’s an enzyme blend that I love. And I actually may start manufacturing it soon. But for now, I’m just mixing these. And the course attend for me is a mast cell stabilizer. Now I don’t know about like trauma, necessarily physical trauma, aggravating mast cells and creating a histamine release. But it would make sense if there’s a stress response from the body, you may be pulling out more histamine, I’m thinking of like a, I don’t know, a car crash or some sort of immediate trauma, you’re probably going to have some histamine to really help increase inflammation, but overall, you don’t want that long term.
Dr. Justin Marchegiani: 100%. Yep, that makes a lot of sense. So there’s other pathways you mentioned, right? So the course attend, like you mentioned earlier, that’s going to help with the TNF alpha pathway. So TNF alpha is another inflammatory cytokine. So think of a lot of these cytokines are like inflammatory chemical messengers, we have cytokines, we have interleukins, we have nuclear factor, Kappa beta, we have TNF alpha, these are all these chemicals, signalers. And so when we have inflammation happen, these type of chemical messengers can amplify inflammation, the effects of inflammation, systemically. And the problem with inflammation is it’s helpful in the short run, because it helps drive blood flow and helps the healing repair process. The problem is, is when it hangs around too long, right? So for like an acute injury, it’s probably good. I think part of the reason why that pain and inflammation is there is to keep you on your butt, so you’re not continuing to damage that area. So I think part of it is, it’s Hey, you hurt yourself, let’s kind of like rest a little bit right part of its that it’s also going to aggregate a lot of immune cells to help heal the injury, preventing infection, it’s also there to help with healing the body up, right, because the body is not about performance when it’s injured, it’s about band aiding the crap out of that area. So the problem with that is the body doesn’t care if it laid down a whole bunch of scar tissue. And that area is now going to be less flex, less flexible, and less mobile. It just wants the body to heal. So now you have to say, Well, I’m also interested in performance too, right? So then you have to look at the fact that like, Okay, I’m going to reduce inflammation, I probably should still be more mobile, I’m sorry, less mobile moving less, because my body wants me to move around less. I’m reducing the inflammation, pain naturally. But I still have to make sure I don’t overdo it. So you have to make sure if you reduce the inflammation, you still don’t overdo it because your body’s creating that pain to keep you from not moving as much. You probably want some movement, but not as much to hurt yourself. And then number two, you really want to remodel that inflammatory scar tissue. And that’s where you know, massage, soft tissue work, adjusting, maybe some some rolling, some foam rolling, gentle things like that to kind of help realign that soft tissue. So it’s more functional and structurally stable. That’s better in the long run.
Evan Brand: Oh, yeah. Good point. I forgot to mention that. It’s not called the Theracane but it’s similar. I’ve got this wooden like cane from like a physical therapy office like it’s a, it’s a wooden cane basically, and it’s got the wheels on it. I’ve been kind of digging that into my upper mid back area kind of work in my traps. I’ve been just doing some light stretches. I’ve been doing some lateral pull downs, I love lat pull downs, I’ve been doing some seated rows. I’ve been doing my roll machine. So just gently trying to work the area. And I do that after I take these enzymes. And I do notice that it definitely warms up the area and I do feel more loose. So I’m trying to think of you like you and I always talk about you have this stacking effect, right you’ve got the anti inflammatory diet as the foundation, you’ve got the omegas coming in to hopefully help lubricate reduce inflammation. We’ve got the anti histamine anti mast cell course attend. We’ve got the ginger working on the Cox pathway, you’ve got the tumeric you’ve got the boswellia. I mean, that’s just really the synergistic thing here. And I’m not I haven’t taken a single aspirin. So I’m not actually in pain anymore. But like I said, if I sleep wrong, it might kind of flare me up. So I don’t think I’m fully out of the woods yet, but I think I’m 95% there.
Dr. Justin Marchegiani: Correct. That’s good. So in general, we kind of have our Cox pathways right. Now, arachidonic acid can feed those pathways. So a lot of excess omega six junkie, refined omega six excess junkie animal products can definitely feed those pathways that sets the table like I mentioned gas in the kitchen right below spark and can take it off. And then we have our natural herbals like like ginger can help with Cox one. Fish Oil is actually For Cox two at high doses now if you do high doses of fish oil, you can increase what’s called lipid peroxidation. Because fish oil is a polyunsaturated fatty acid, it’s more unstable, right? It’s got a lot of these. It’s got more double bonds in it, right? omega three means three double bonds, the more double bonds that are there, the more unstable the fatty acid is to heat and things like that, the more let’s say it can be oxidized. So having extra vitamin C, or extra vitamin E on board when you’re taking extra fish oil, just to make sure you don’t have oxidation is great. And we already talked about things like systemic enzymes talked about, like, you know, curcumin, liposomal curcumin is better due to the absorption, or something with black pepper in it helps with absorption to already talked about things like Frankincense or boswellia is great, you could always do some white willow bark, which is kind of how aspirin is naturally made, right? aspirin works more on Cox one. So aspirin is going to be your other natural source. And you can do white willow bark, which is the natural form of aspirin, which is great. There are things like Tylenol, but Tylenol works more on the central nervous system perception, right? So it decreases the nervous systems, perception of pain. And then of course, at the extreme example, we have opiates, which block the pain receptors in the brain, the the opiate receptors in the brain, not the best thing because you’re just decreasing perception of pain. Obviously, the opiates are way more addictive, right. But we can block some of these natural pain perceptions with CBD oil. So CBD is another great way to reduce perception of pain. But we got to be careful of, you know, Tylenol, or things like opiates, you know, opiates due to their addictive qualities. And Tylenol actually chronically can reduce gluta file and you can just type in Tylenol and low glutathione level. So if you’re taking Tylenol longer term, you definitely want to take it with NAC and or some cloudify and just to be on the safe side. But in general, we want you to try to do more of the herbals and more of the natural stuff out of the gates because that really, really, really can help reduce inflammation.
Evan Brand: Yeah, well said. Yeah, and the acetaminophen glutathione yeah, it’s a big problem. So that’s why I stayed away. So people listening, if you’re didn’t jump off a ladder like me, and you’ve got osteo arthritis or rheumatoid arthritis, or sports injury, or you’re just trying to heal up maybe post operation, these things we talked about today may be something to implement. And then obviously, working on all the other root causes too, because you are not just what you eat, you are what you digest from what you eat. So if you’re doing all these good nutrients, but you’ve got some type of malabsorption issue in the gut, you’ve got ridges on your fingernails, you’ve got thinning hair falling out here, you may need to look deeper at the gut and try to find some of these more root cause issues that led you to that amount of inflammation or slow recovery in the first place. So if you need to reach out, please do so. Our websites are JustinHealth.com. That’s for Dr. J. He works worldwide via phone, FaceTime, Skype, zoom, whatever. And then me Evan Brand, EvanBrand.com. So JustinHealth.com, EvanBrand.com please reach out if you need help. We love helping you guys. This is just a wonderful situation that we’re in to be able to help people across the globe get solutions to their health issues.
Dr. Justin Marchegiani: Absolutely. And one last thing to comment is people talk about what we know about cortisone and prednisone injections, right for chronic pain, right? This is a common thing. Well, what’s our natural cortisone? What’s our natural anti inflammatory? Well, our adrenals. So if you have weaker adrenal is going into this stuff, you may not be able to make good amounts of our natural kind of anti inflammatory hormones like cortisol or cortisone, right? This is important. Now I had a family friend come up to me recently, they had chronic pain issues. And it was asking me some questions about things. And they were telling me Oh, I just got a cortisone injection. It’s doing really great right now I said, Well, number one, that’s that’s a really big mistake. I said, you can do a cortisone injection only, only one if it’s really debilitating, and you need that to buy you time to fix the underlying issue. The problem with any injections of steroids is they start breaking down the tissue and the cartilage and the ligaments and the bone in the joint. And actually, over time, they’ll stop giving you cortisone injections in an area after two or three injections sometimes, so then now what now you’re kind of stuck. So the only way ever support a cortisone injection, is if that’s buying you time to do all the other stuff and the pain is so debilitating, you’re just doing that to buy you time because if you’re not figuring out and doing all the other stuff, while that quarter zones working, you’re just going to just repeat its pattern over again three to six months later. And that’s not a good situation. So ideally, you maximize the low hanging fruit, hopefully you won’t have to go to that. And then if you have to go to it, you at least use that time to do more of the right things regarding soft tissue chiropractic work anti inflammatory, there’s another device we we use here we’ll put a link below for the newbie device which is a bio electric device that I have and I use that helps reduce inflammation with special bio electric wavelengths. Electricity wise that reduce inflammation, improve blood flow, help improve the muscle integrity in that area. So the muscles take over the stress the joints and the ligaments and that’s cartilage would normally absorb right we want our we want our shocks to absorb The force not the sensitive material in the in the vehicle so to speak, right we have shocks for a reason. Think of shocks in your body as like muscles. Think of the sensitive tissue as ligaments and cartilage, right? Those are going to be more a vascular right poor blood flow the muscles more vascular. So what’s good let the vascular shocks absorb most of that issue most of the inflammation and for so I’ll put the link down below for that too. So you guys have that for references. Anything else, man?
Evan Brand: Yeah, the sauna. The sauna has been helping me too. I love sitting in there. Yeah, that obviously warms me up to so I have the infrared heaters in the front and then the ceramic around the edges. So I do try to rotate make sure that the infrared does hit my back and it does help me quite a bit. So that’s also another beneficial thing. Epsom salt baths are very helpful potentially using a floatation tank, a float tank with just tons of Epsom salt and their magnesium and that’s that’s also another great strategy. So hope this helps people and take care yourself. Like I said, if you need to reach out please do JustinHealth.com or EvanBrand.com look forward to helping you soon.
Dr. Justin Marchegiani: We’ll be right over recommended products down below so you guys can see that and take advantage of the things that we use clinically for our family, ourselves and our patients worldwide.
Natural Ways To Increase Your Glutathione Levels | Podcast #292
Glutathione is an antioxidant that is capable of preventing damage to cellular components and also gives a lot of benefits to our body. For today’s podcast, the topic that came to mind is glutathione. Dr. J and Evan point a lot of information and tips on how glutathione is important in our health, how we increase our glutathione levels the natural way, the pros and cons, and a lot more. Read and listen below.
Dr. Justin Marchegiani
In this episode, we cover:
00:37 Glutathione as Tri Peptide
06:06 Conditions Associated with Low Glutathione
11:32 Glutathione in Helping with Treating Cancer
23:03 Food and Supplements
38:46 Tips, Ideas for Higher Glutathione Levels
Dr. Justin Marchegiani: Hey guys, it’s Dr. Justin Marchegiani here. Really excited to chat with y’all today. We got Evan brand here in the house, Evan, what’s cooking my friend?
Evan Brand: Oh, not much. We cook some bacon and some pastured sausage earlier, but nothing is cooking at the moment beyond that.
Dr. Justin Marchegiani: Awesome, brother. Well, I know we were chatting about topics that for today’s podcasts in the pre show and glutathione was one of these topics that kind of came to mind based on challenges that we’re seeing with our patients based on things that we’re seeing in our comments section on our pages, and we decided glutathione will be a great topic for the show today. So really excited. Let’s just start off the day what is glutathione? So glutathione is a tri peptide. What does that mean? Tri means three, Peptide means essentially amino acid. And there’s three amino acids that make up glutathione. Glutamine, cysteine and glycine, those are the big three glutamine cysteine glycine. Now we really important because these are all amino acids. Sulfur rich amino acids and you’re not going to find a lot of these amino acids by the way in in plant based products, you’re going to find the mainly in animal based products. So for amino acids are much more rich from animal than you do plants. A lot of plant based products tend to be lower in sulfur amino acids and you actually have to combine them to even get them appropriately right. That’d be like rice and beans, right? Because they’re missing certain amino, so you got to combine them just right. So glutathione really important try peptide, glutamine, cysteine, glycine, glycine, very, very high in bone broth and collagen. Right. cysteine very high and a lot of high quality animal products. Also whey protein. Okay. And then glutamine is obviously in a lot of gut healing supports glutamine is really important for the gut lining. Glutamine can also be more inflammatory, too. If you don’t have enough B six, it can go down glutamate pathways without B six. So we also want to make sure we’re getting enough B vitamins and we’ll talk about glutathione metabolism. We’ll talk about some of those pathways and what nutrients are needed to maximize glutathione and healthy glutathione metabolism besides just those try peptides, glutamine, glycine, and cysteine. Any thoughts seven?
Evan Brand: Yeah, I think it’s all excellent. I look forward to breaking it apart more. Now, how do we measure glucose ion? One way is we like to look at organic acids testing. There’s not a direct marker that says, glutathione, boom, that’s your level. But using some of the metabolites that you can measure in the urine, you can get an indicator of it. And we know that when people are exposed to toxins, whether it’s mold, or heavy metals or pesticide or herbicide, whatever it is, you’re going to be reducing your glutathione levels. And as you mentioned, you know, people that are on veggie based diets, they’re probably going to show up low. And so we can measure that on the oat test other other ways that you know, have to measure glutathione or is that what you use?
Dr. Justin Marchegiani: So yeah, the big ones, like you mentioned are going to be the pirate glutamate. The sulfate and the alpha hydroxy butyrate. Those are going to be some of the best ways to test it on the organic acids. Those are precursors to solidify own and a lot of the the sulfur nutrients cysteine, glycine, glutamine, those are big, big ways to do it. So when you look on the organic acids section, it gives you about five different organic acids that are that are very, very helpful at looking at glutathione the big three of the ones I just mentioned, I’ll pull up a couple others that I use as well, that are more on the precursor side for glycine. So glycine is another big one. Because that’s really important for glue to found as well then there are others that look at glutathione than the cysteine and the glutamine on top of that I’ll pull that up in one second. So organic acids are great. There’s also a red blood cell glorify on that you can do doctors day that does it. I think spectra cell does it.
Evan Brand: Have you ever done it or do you run it or do you think it’s not worth it? If we’re doing that oat.
Dr. Justin Marchegiani: I think if you already have a good look at the oat, there’s four or five markers on there that you can elucidate from so I think the oat’s fine, but if someone has a chronic condition chronic detoxification issues, I don’t think it’s a bad way to just kind of give it a an extra look, see, especially if you’re struggling on the organic acids, or if the organic acids look good, but you’re still having some detoxification issues, I don’t mind running it. A lot of times I’ll run an ion panel with some of my patients which will come with an organic acid and a intercellular nutrient blood test as well. So it would be on there and then also be on the organic acids so that’s a way to kind of get a package deal on and kind of get two for one if you will.
Evan Brand: Yeah, I love the combos. Love the combos yes to like you mentioned the, like vegetarian sources where people are going to get sulfur to boost glutathione. I mean, that’s going to be the cruciferous stuff. This is why you and I will use some of these like broccoli sprout extracts. There’s some kale sprout extracts, things like that. There’s different greens powders, and there are some encapsulated products that we use and I’ve used them with children were if they weren’t able to swallow or they couldn’t stomach like a encapsulated glutathione or maybe alive was almost like they didn’t like the taste and some of the broccoli sprout extracts tend to work pretty good.
Dr. Justin Marchegiani: Totally and on the organic acid just to highlight sulfate and pirate glutamate are the big ones for glutathione that’s really big. And then the other ones are going to be to methyl hip right we’ll really look at glycine and then the gluco re also looks at glycine so those are some of the other ones that can be ultra ultra helpful.
Evan Brand: This is why oat test is like I don’t know desert island you only have one test to choose from between like a DNA stool and an organic acids. Oh, man. It’s tough. I mean, I some days I go with the oat over the stools, my only test if I had to pick one.
Dr. Justin Marchegiani: Well, it can be helpful because you get a good window into yeast and fungus, which can be really helpful. So that’s really nice. And then also, we can talk about gluten if I own the different conditions that are associated with their other nutrients that help you recycled modifying and that are very helpful in the healthy metabolism of fluidify own and we have a nice handout here. I’m going to pull up so you guys can see I think it’s under Very, very, very helpful. I’ll pull this up here for you guys to see. So there’s a bunch of different conditions that are associated with low glutathione. Everything from aging to all simers to cancer to chronic liver, cognitive issues, cystic fibrosis, diabetes, hypertension, any immuno deficiency and chronic viral issues, lupus, mental health issues, multiple sclerosis, neurodegenerative issues, Parkinson’s, I mean, this is like through the freaking roof. It’s unbelievable. The association with other conditions, it’s not saying this is a direct cause they’re just saying, hey, they test a lot of people for who to die on. And they just find this chronic association with these issues. Now, I would say there’s definitely going to be there’s definitely going to be a causation link there for me, it’s hard for research to say that it takes a while for research to do a causation thing you got to do a metabolic war and you got to really take people in, give them Low, low defiant take people out, give them some glutathione and study the different it’s really hard at metabolic Ward studies are tough. So it’s you have to kind of look at more of associative studies versus metabolic Ward that really give you the causation. Let me show a couple things here for you guys to see. me pull this up for you guys.
Unknown Speaker: Okay, can you see my screen Evan?
Evan Brand: It’s loading. Yep, there it is.
Dr. Justin Marchegiani: Okay, cool. So these are a bunch of the conditions here that are associated with low glutathione. And then there are the links here. So you can actually see the scientific studies right Alzheimers, the emerging role of glutathione and an Alzheimer disease, right? You can see diabetes glutathione synthesis is diminished and patient with uncontrolled diabetes is really important. And again, this is the article right here I wanted to highlight is called a review of dietary phytonutrients for gluten support. It’s in the journal nutrients September 2019. So pretty, pretty fresh study. But this pathway here I really wanted to highlight for everyone. I think this is super important. When I get this just the right size, does that look good to you?
Evan Brand: Yeah, looks perfect.
Dr. Justin Marchegiani: Okay, cool. So let me kind of highlight a couple of things that are happening here so people that are listening, we got a video on screen so you guys can actually see the different pathways and how glutathione gets into the cell and works. So you have your three major amino acids you have cysteine right here, which can come from an acetylcysteine and can get converted from cysteine assisting right there, you have glycine, right very high and collagen and bone broth. That’s why I like to do my 20 grams of collagen in my coffee every morning. Okay, and then you have your glutamate or glutamine inside the cell. So outside the cell, these are the big two amino acids and then inside the cell, you have your glutamine that gets conjugated here. Now also outside of the cell, look at the the green vegetables right the brassica vegetables, the high cruciferous vegetables. Some of the polyphenols like green tea are very important in this glutathione to conjugated, basically it helps conjugate a lot of these foreign chemicals xeno biotic means foreign chemicals, you know, biotics could be xeno estrogens that could be xeno neurological things from pesticides right? So basically they’re going to be chemicals that are foreign to the body that are stressor on the body this can help with fluidify on to GST and conjugate Gosh, conjugate just means binding a protein to it, typically, so the body can excrete it via the stool or the kidneys or urine, right?
Evan Brand: Now, here’s the thing. You mentioned that big list of conditions so it would make sense why cancer would be associated with low glutathione because this pathway you’re showing if you’ve got a build up of all these toxic chemicals and hormone disrupting chemicals whenever if that pathway screwed up. I mean, it sounds like you’re going to end up sick so it’s not that like you said, it’s not causation, but that pathway could be you know, if I were somebody like focusing on an anti cancer regimen, I mean, this pathway here would be a huge piece of the puzzle.
Dr. Justin Marchegiani: 100% and this GST stands for glutathione S transferase and they’re actually making drugs that are glutathione s transferase in nature. So this GST is very very very important in excreting toxins and crap outside of the body. And we know this to like a lot of the things we may use on the brassica vegetable side, we may do broccoli sprouts, we may do sulfur rich compounds like dim, which is di n Dom methane, or we may do indoor three carbinol these are all going to be so for concentrated compounds, we may even do things like calcium to glucose rate. And these can help improve this clarify own clarify on s transferase pathway. Any comments there?
Evan Brand: I’m trying to figure out what the I would love to learn about that you’re saying they’re using or they’re making prescription drugs to work on this pathway?
Dr. Justin Marchegiani: Yeah, so let’s um, let me see I can pull it up here on screen for you. Can you see this right here?
Evan Brand: We’re still on the image we still see the image of the pathways.
Dr. Justin Marchegiani: Okay, let me just pull this up here this is an older study but you know I like to just show people what’s going on so they can actually see it
Evan Brand: Because here’s if they’re gonna make a prescription here’s what they’re going to do they’re going to jack up the price 1000 X to do the same thing that in AC or DC now do yes sir.
Dr. Justin Marchegiani: Okay, so you can see this the role of fluidify on s transferase. In anti cancer drug resistance. So it seems like this may be helping a lot of the cancer drugs work better. So they’re talking about who defined as transfer rates are a family of phase two detoxifying enzymes that help catalyst catalyst is a gluten independent enzyme. And it basically helps when I say conjugate that means bind a protein to it, a variety of endogenous and exogenous toxin. So endogenous means toxins that are made by your body. exogenous means toxins that are come into your So think of mold and pesticides as exogenous. Think of maybe yeast overgrowth or bacterial overgrowth and those toxins being produced like acid aldehyde, maybe being endogenous. Does that make sense?
Evan Brand: It does. I actually found something on this. I’m looking on this drug website, and actually found out here that for chemotherapy, doses of 1.5 to three grams of glutathione have been given in a 15 to 20 minute time period right before a chemotherapy treatment.
Dr. Justin Marchegiani: Totally makes sense. Yep, totally makes sense. So I’m trying to go down to the conclusion of this one study here. I haven’t gone through it yet. Yeah, I’m just trying to look through this here. Alright, cool. I’ll have to go through this here later on. But I mean, it just shows you how important glutathione is with detoxification, cancer and also we can talk about the immune system, right. There’s the reason why that page had immune issues, AIDS and viral issues as being a low glutathione issue. Because gluten has a major, major role in immunomodulation and immune balancing any comments there?
Evan Brand: I just wonder where this conversation is happening in an oncology office though, hey, we need to boost up your clue to find out I want you to eat broccoli sprouts and take some extra NAC and vitamin C and some of the stuff we’re going to get into. It’s like, Where’s that happening? I mean, maybe in a holistic oncologist office, but I feel like your conventional guys, it’s still just the chemo model. It’s not going to be anything like this. Exactly wrong. If you’re, you know, cancer doctor out there, then let us know who you are, what you’re doing. We’d love to hear about it.
Dr. Justin Marchegiani: I mean, the problem is, people on the pharmaceutical side or conventional medicine side, their perspective when they look at things is how can we make a drug that modulates this pathway or interacts in this pathway? The problem is once you start making the drug, you’re forgetting why these pathways are low to begin with. Right? Hay diet issues, digestion issues, stress issues, exposure to toxins, right They’re forgetting why these pathways are low to begin with. And then number two, anytime you make a drug, you can’t patent Mother Nature. So you can’t patent the actual codify on building blocks, you have to do isomers, or different substrates that look similar, but may not be the real deal. And the problem is once you start deviating from Mother Nature, all drugs have what Evan?
Evan Brand: They have side effects, side effects. It’s like the designer babies. It’s like, oh, let’s play with these genetics. We’re going to make this baby have this color hair and this color scan and whatever there. It’s not what nature intended.
Dr. Justin Marchegiani: Exactly. So once you start doing that, then you have an increased risk of side effects. And because you can’t patent Mother Nature, you know, that’s the problem. That’s the big issue. You can’t patent Mother Nature. Therefore, you have to go and create compounds that are isomers that look similar, they may work a little bit will never work as good as the real thing. And then you’re going to have a whole bunch of side effects.
Evan Brand: Yeah, let’s get back to that first paper that you and I have pulled up with the graphic on it because we wanted to go through some things that have been shown to help with this whole glutathione people think just pop glutathione pill in that scene of the day. But there’s and that’s true. You can do that. You could do your oral, your sublingual, your zomo, your intravenous glutathione. But there’s other things along the way they can help, like NAC is a game changer.
Dr. Justin Marchegiani: So let me let’s kind of let’s work from the top and go down. Okay, so we talked about what’s happening outside of the cell, right? We need cysteine. We need glycine, these are really really big pathways. We talked about maybe some of the sulfur compounds in the vegetables, we hit that right now inside. If we go to the top of this cycle and work our way down, you can see folic acid or we’ll just call it full late. Okay? And you can see thf this is tetrahydrofolate and this goes to mthfr. Right everyone talks about methyl tetrahydrofolate reductase right mthfr right. So you need full A B vitamins, and then you’re also going to need b 12 betaine, which is trying methyl glycine, so these are important nutrients that are needed. So this pathway can go around and essentially when you have an mthfr issue, this pathway up here, this enzyme is lower. Therefore, you need more of these nutrients here to run this pathway and of course not folic acid we activated fully, whether it’s cat you know, folic acid or calcium D fully or mthfr folate, we need to activate it fully. And then you can see here I’m assigning gets stuck as homocysteine if we don’t have enough of these nutrients and we know homocysteine can create vasculature inflammation, inflammation in the vasculature right? associated with heart disease. You can go look at the research of Kilmer McCauley over at Harvard, and we need enough of these nutrients to take pining to go to homocysteine and then go all the way down to cysteine down here so then you can see cysteines are really good sulfur amino acid cysteine then binds with glutamate or glutamine. Okay, and then you can see cysteine and glutamine go downstream to actually make glutathione and guess what else you need? Well, you know, if you look at some of these nerve pathways over here where you know, you know that multi level product called Protandim, right, it’s got a lot of the phytonutrients the green teas ashwagandha fits in this category, a lot of bioflavonoids like resveratrol, vitamin e omega three and guess what? Magnesium. So these nerf two which is really important for binding that cysteine to the glycine and making glue to find magnesium is really important as well. And then you can see glutathione also is very Selenium dependent. So fluidify on gets utilized in the body, it needs to be two and then also when it gets reduced to reduce go to diet, it needs vitamin C and lipoic acid to bring it right back up and to recycle it. So if you don’t have enough vitamin C or lipoic acid, which is a silver component, we may not recycle our glutathione and then Selenium is very important too because Selenium helps take the metabolism of Go to found it spits out a lot of hydrogen peroxide right here, h2o. And Selenium actually binds an oxygen off and makes it water. So it actually helps the metabolites of glutathione that are very inflammatory h2o to and it turns it in the water. And then we use a lot of these phytonutrients as well to buffer that oxidative stress.
Evan Brand: It’s beautiful. It’s a it’s amazing how that happens. So you and I’ve talked about autism and behavioral issues and detoxification issues and all that and how it’s related to mthfr defects. So what we’re kind of showing here can show how just simply improving the methylation component of this picture can improve detox because methylation helps with detox on its own, but you see the mechanism downstream of glutathione. So this is why some kids that we work with even just by improving methylation, and as you mentioned, we’ll give them like an activated, you know, l mt hf or something similar data We’ll clear up some of the mood issues that will clear up some of the skin, it will clear up dark circles under the eyes. I mean, just improving methylation alone could be a game changer. My favorite part of this whole picture is the vitamin C, because in this paper that you and I were looking at, it was shown that even just taking 500 to 1000 milligrams a day of vitamin C for 13 weeks. So what’s that give it three months or so led to an 18% increase in gluten ion levels? So that’s it. That’s such low hanging fruit. You and I are such huge fans of addressing low hanging fruit. I mean, how much easier can it get? You’re boosting Bluetooth on 20% just by vitamin C. I’m rounding at 18 but I’m calling it 20. I mean, it’s close enough.
Dr. Justin Marchegiani: I wanted to highlight this one study here so you can see it to kind of just dovetails with everything we’re talking about. I want to just make sure that makes sense. pull this up screen here so you guys can see it.
Evan Brand: Okay, while you’re doing that, I’m going to just keep ranting about other nutrients. So yeah, I just pulled up Selenium. I want to say one thing about that real quick. So Selenium. It was found that beautify on increases just by giving Selenium as well. So I’m not saying spot tree. But let’s see someone had a thyroid issue were like, Hey, you really need some extra selenium, that alone could be boosting Bluetooth ion. So it’s really, really cool.
Dr. Justin Marchegiani: And the nice thing is when we’re looking at patients, we’re testing all these nutrients because of course, yes, it’s going to help but if you’re deficient in one nutrient over the other, that nutrient could be the bigger linchpin for supporting your glutathione. Right. Now, this study, I thought was really important because one of the major mechanisms of glutathione and how it works with cancer is it modulates the immune system, better immune system, right? It controls cancer cell growth, right? What’s cancer just cells growing out of control, and then it helps with oxidation, right? oxidation is when you lose electrons and cancer is very oxidative. It causes a lot of loss of electrons which then creates a lot of free radical stress and damage. To the DNA into the immune system, so really powerful abstract here, role of fluidify on and cancer progression and chemo resistance which means resistance to chemotherapy. It talks about codifying, placing an important role in the cellular process, including proliferation and a pop ptosis. That means cells growing and cells dying, so it helps cells so they don’t grow too much until they die sooner. That’s good. We need that. Then it talks about while glutathione deficiency or decrease in glutathione ratio leads to an increase in susceptibility of oxidative stress. What does that mean translation, you lose a lot more electrons, and that creates free radical damage and DNA implicated in the progression of cancer elevated glow to final levels increase the antioxidant capacity. That means it helps you take electrons that you’ve lost it helps bind to them and stabilize the cell and resistance to oxidative stress observed in many cancer cells. The presence highlights the role of gluta thiam as a cytotoxic That means it protects the cells from being damaged. Carcinogenic means means the formation of cancer. So it protects cells from being inhabited by cancer and the sensitivity to tumors to the cytotoxic agents, or the cytotoxic effects of anti carcinogenic agents, so what that means it’s going to protect you from getting damaged by chemotherapy. And it’s going to protect you from the cytotoxic effects of chemotherapy. So that’s kind of the the layman’s translation as we go. So what’s the moral of the story glutathione protects you from the damage of cancer, it protects your cells from growing into cancer and it protects you from the damage of chemotherapy. So three ways it’s very beneficial.
Evan Brand: That’s amazing and not that this was the glutathione cancer podcast, but hey, I’m sure everybody listening would agree that you don’t want cancer. So, of course, you can’t say glutathione prevent you from getting it, but man, it’s an incredibly protective molecule.
Dr. Justin Marchegiani: 100% Evan, can you see me back on screen now?
Evan Brand: Yes, sir.
Dr. Justin Marchegiani: All right. Awesome. I think we hit that one really, really well. Let’s keep on rolling though, if you don’t mind. So we talked about that pathway, which I thought was really helpful. We’ll put the links down below. So if you guys want to see it, why don’t we talk about some of the big foods, so beautify on right cysteine glutamine glycine, so now we just back into it what foods are really high in cysteine, glutamine lysine? Well, of course, things like whey proteins and to be great as long as you’re not ultra dairy sensitive whey proteins great sulfur rich foods are going to be helpful like a lot of your brassica cruciferous vegetables right bok choy, broccoli, brussel sprouts, cauliflower, kale, mustard greens, turnips, again, the problem is that’s not going to really help you with a lot of the intercellular glutathione but it’s still going to be helpful. Now what other other foods that are more high in some of those intercellular nutrients? Well, you’re going to see all of your high quality animal products, beef, chicken, fish, eggs, all of these things. The higher quality the animals are, meaning the less hormones the West junk, the less toxins, the more they’re fed high quality grass, the more nutritionally dense they’re going to be.
Evan Brand: I found, I’m looking at a couple of like food data sheets. So in one large egg, you get almost 150 milligrams of cysteine. And who knows if that’s even, I mean, that could have been a conventional egg. I mean, what about like a fully pastured organic egg, you may even get more cysteine you’re talking almost I mean, if you do two eggs, you’re at 100% of even over 100% of your daily intake for assisting with two eggs. Love sunflower seeds, and a handful, a one ounce handful of sunflower seeds. You’re at over 100 milligrams of hemp seeds. You get a ton from hemp seeds as well. So like let’s say you did a smoothie in the morning where you put in some collagen with maybe some hemp seed or maybe some hemp protein added to it. Maybe a grass fed way. I mean you’re going to be stellar in the solidify on generating department.
Dr. Justin Marchegiani: Love it. 100%. So your animal products are always going to be the best way to go off the bat just because of how high they are and how nutrient dense they are. Also, when you look at amino acids and plants, you have to look at the digestibility of the amino acids, there are certain scales, you can look at that look at the digestibility because plants have a lot of anti nutrients that bind a lot of these amino acids up because plants don’t have claws and teeth to fight or flee. So how they survive is they have anti nutrients which makes some of their nutritional compounds harder to break down which means they pass through the stool and then they can grow seeds and flourish and other parts of the soil. So they have to have anti nutrients so they can pass other animals digestive tracts right. Animals just have claws and teeth to fight and flee plants don’t so there’s a lot more anti nutrients that prevents some of the digestibility whether it’s mineral blockers like fighting And oxalates, whether it’s trypsin inhibitors that help decrease proteolytic enzymes, so their proteins can’t be digested, whether it’s lots of hard to process fibers, all those things are potential and could be, could play a big role in those amino acids not being fully absorbed.
Evan Brand: Well, here’s a couple other things, too. So in that paper, they’ve got a table on there that talks about preparation of the sulfur rich vegetables. And apparently freezing of broccoli does reduce the sulfur. And then of course, if you are eating it overcooked, you’re likely gonna it’s like a sweet spot, right? Because we’ve talked about this before nutrient density of raw versus lightly steamed. So lightly steamed is going to be the way to go. But if you cook too much, then you’ve broken it down that way. If it’s frozen broccoli, then you’re already at a disadvantage state. So it sounds like it’s just too difficult. I mean, I’m not saying that. veggies aren’t important. I still eat a ton of veggies, but if I’m looking to it To increase glutathione I’m not just going to be doing a broccoli smoothie, I’m going to be focused on the way and the collagen. And also, here’s an interesting one. Number one food for my pining king crab, one crab leg, you’re over 700 milligrams of Matheny. It’s the number one source. So if you like crap out there, there’s a reason to like it because of them.
Dr. Justin Marchegiani: Love it. I love it. I think that’s really, really awesome points. So a couple of kind of deal breakers, let’s call it low stomach acid, we don’t have enough high quality stomach acid, it’s gonna be hard to break down a lot of these sulfur rich compounds. So of course, that’s going to be a big, big problem. So if we don’t have enough stomach acid or enzymes, we’re not going to be able to digest a lot of those animal products, and also a lot of the sulfur rich vegetables. Let’s be real, a lot of them are very high and fodmaps, right, fermentable oligo, disaccharide, mono and polyols. So guess what, if you have SIBO guess what kind of response to those vegetables you’re going to have? Yes. A lot of bloating and gas, they may even disrupt motility they may even cause diarrhea or constipation. So you may not really be able to tolerate much of these vegetables. So a lot of people that are like on a carnivore template, a lot of times they have SIBO, and a lot of autoimmune sensitivities and they’re really sensitive to a lot of the anti nutrients in these plants. So a lot of people kind of come down on people that are doing a carnivore template, but the reason why they do it is because they feel significantly better because of the anti nutrients and because a lot of times there’s some SIBO going on and cutting out those fermentable carbohydrates or even going carnivore can help starve out some of those critters too.
Evan Brand: Yeah, and important. And let’s point out that’s not forever. I mean, if somebody is on a carnivore template, we’re using that to stabilize those people until we can work behind the scenes on these other issues like the infections you mentioned. Yep.
Dr. Justin Marchegiani: And we may be able to add some other things down the road for sure. So a lot of your vitamin C rich vegetables are going to be awesome. A lot of the sulfur ones a lot of the lower sugar fruits are going to be awesome. Those are going to be great things to do off the bat. Of course, we talked about yourself. Millennium rich foods as well animal products, oyster seafood, high end zinc high in selenium, Brazil nuts can be excellent as long as you can tolerate the knots very, very high in Selenium. We talked about the stomach acid and the enzymes as being a rate limiting factor because of the fact that they need good acid levels and enzyme levels to be able to break them down. And also say we talked about this earlier. Vitamin D is really important for glutathione in the brain. Can you talk about that a little bit, Evan?
Evan Brand: Yeah. So I think the best way to talk about this and implement it is through the nebulizer. So there was a couple papers talking about increase included found in the brain. I don’t have it pulled up. But long story short, I’ve looked into this. I’ve done it over the weekend. I will tell you, I get more energy, I get more mental clarity. I feel honestly I feel relaxed. I mean, it’s almost like I snuck in a little bit of gamma powder into my nebulizer something because after breathing in the glutathione, I just felt relaxed. Maybe because I was like focusing on deep breathing and such while I was breathing it in. But I looked at a couple papers on the administration method. So just eating glutathione orally meaning in a capsule form like zomo, doing foods to increase it versus IV versus nebulized. The only way to get it in the brain is nebulizing. At we’re talking at therapeutic levels now, the some of the glutathione made in the body get into the brain, probably, but we’re talking if you want to just crank up brain power, let’s say you have a traumatic brain injury, maybe you had a head injury or you’re an athlete or a soccer player or you fell off a bike or you fell down a set of stairs or you have mold because we know mold damages the brain to me nebulizing with the sodium bicarbonate and the saline solution. It’s a miracle cure, so I can’t say enough good things about it.
Dr. Justin Marchegiani: No, I love it. I think it’s really, really important. I wanted to highlight a couple more things that I thought were also very important. Let’s talk about supplements. So we talked about a couple things when we review that solidify on pathway that you guys can see the video on. Alpha lipoic acid is very important in recycling clarify him. Also, milk thistle is a really good tone of fire and does help support glutathione levels as well. Vitamin C is really important, right? That helps with reduced glutathione and help activating it again, that was also very, very important. Oh-
Evan Brand: Here’s one thing. Go ahead. Here’s one thing I forgot to mention this was in the paper. So I kind of went on a tangent on the on the nebulizer. But in that particular paper, you and I were discussing it I was wrong. It is true that you can increase at least this was in rats. So is it the same in humans maybe. But by just giving an IV dose of NAC they were able to increase glutathione in the brain. So what about oral NAC? Does that increase glutathione in the brain? I don’t know. But at least in that paper IV NAC did boost Brain levels include glutathione.
Dr. Justin Marchegiani: That’s great. Yeah, I imagine over time, I mean, those amino acids will eventually cross. I know sometimes the amino acids cross the blood brain barrier and then the glutathione converted in the brain I think glutathione maybe too big to cross the brain itself. I know some of the amino acids like cysteine Oh l cysteine. can cross the blood brain and can then convert to glutathione in the brain. So I know cysteine is a big one. I don’t think NAC can but l cysteine can.
Evan Brand: You think just because it’s smaller?
Dr. Justin Marchegiani: Yeah, smaller because NAC gets broken down into cysteine by the body and some people they say just take cysteine because I know a lot system is very important with adrenaline. And we know adrenaline is a really big, nervous system. amino acid right? And we know dopamine actually gets converted to adrenaline and we know dopamine to adrenaline. That pathway involves sulfur in particularly cysteine.
Evan Brand: So wonder, I’m just thinking out loud just for for my purposes. So I want to People that are having issues with anxiety, if they would be able to reduce the anxiety by boosting up that pathway working more on sulfur.
Dr. Justin Marchegiani: Sulfur can be really helpful. Now in my line, I have a product called detox and he knows that we’ll have some cysteine some and acetylcysteine some calcium to glucose, which is a really good binder for mold and for hormones, refining, cysteine, taurine, glycine, so all the amino acids which is really helpful, I like that a lot. I’ll also do a lot of the the phase one nutrients, a lot of the antioxidants, a lot of the B vitamins, milk thistle, those kind of things for phase one support. Phase One is taking toxins that are fat soluble and converting them to water soluble phase two is going to be water soluble, excrete it out the body and that involves lots of sulfur, all the amino acids I just mentioned. And with some people we may do a combination of El glue or lipids almost glutathione we may do glutathione, there’s another good found has these little these little Bucky balls? Can you talk about that?
Evan Brand: Oh, yeah, I love I love the seat elated. Yeah, so there’s a couple out there with the Bucky balls that basically the idea is to try to just shrink the molecular size of it, so you can kind of sneak it into the cell. So there’s, you’ve got the light zomo where you’re going to do like a sunflower and then you’ve got this buckyball idea now I don’t know if it’s a carbon molecule, if this is the same thing as the C 60. You and I’ve been talking about or what but but there are ways to to make Bluetooth ion smaller for me, I just look at the papers on it. And the acetal version is the one that I believe you have your own I have my own as well have an S acetal ad glue defi on. I’ve had people doing here just just a quick little debate. I’ve had people doing various versions of like Bumble glue defy on and liposomal vitamin C and I’ve measured them and many of these people are still low on the test for vitamin C and glue to violence. So when we switch them over to like an acetal ated and then just a mixed ascorbate I see the levels come up so it’s not that I’m against the life was almost glutathione. But I’m just finding that the acetal works just as good if not better, and it’s capsule because the lipids almost generally tastes like crap. Or if you’ve got a really sensitive person, there’s going to be citrus oil or some other flavoring to cover up the terrible beautify on taste. And then those people don’t tolerate it, and then they’re not compliant and then they don’t get better.
Dr. Justin Marchegian: 100% Yep, I totally agree. So right now, I use a lot of lipids almost, but you still do the seagull and you still get good results with that clinically?
Evan Brand: I do. Yeah, it works great. And I feel good on it. So I’ve done an experiment on myself where I’ll go life as normal for a month and then I’ll go acetal I feel just as good Now it could be because my acetal version has a gram of NAC added to it. So I’m kind of cheating because I’m really getting the NAC plus the gluten. Maybe that’s why I’m I’m getting so much better. Oh, so while you were talking I just did a quick search on studies on glutathione and anxiety because you brought up this whole dopa mean endorphin thing and this is not for the podcast, but really more just Brain Candy for me. Turns out Yes, there’s a link between glutathione and anxiety and bumping up glutathione been shown to reduce depression and anxiety. So there you go.
Dr. Justin Marchegiani: I make a lot of that has to do with the catecholamine. The dopa means synthesis in the brain. So I think it’s really really important to know. Dr. Marty hands I think he’s over at neuroscience or neuro research. He talks about how sulfur is very important for synthesis of serotonin and dopamine and a lot of your adrenaline over time you will deplete it, especially when you get stressed and you’re taking a lot of your dopamine and you’re converting it downstream to adrenaline, you will be depleting a lot of your sulfur. Now, what does this matter? So this matters, because the more stressed you are, the more sulfur you deplete, which means you’ll have less sulfur leftover. So now if you’re stressed and now you’re exposed to toxins, or you’re living in a moldy home, you can see how stress can make everything worse because now you have less flow glutathione precursors to help you in that situation.
Evan Brand: Yeah, speaking of stress, I’ve got a paper in nature right here. was called I’ll give you the link in case you want it in case you want to show anybody but it was called glutathione depletion, mitochondrial dysfunction induced by chronic stress. And I don’t know this is a rat thing so you know how they deal with rats they do something to them to stress them out but long story short stress in this paper had reduced glutathione brain glutathionr by over 35% so it would make sense why glutathione would help with depression too because you think about the toxicity I mean, heavy metals and such those can impact neurotransmitter function you can get depressed just for being toxic. So by reducing the toxicity, you’re less depressed. I mean, I think that’s really cool.
Dr. Justin Marchegiani: Exactly. Now a lot of people are asking well where can you get the nebulized glutathione right now the third natural site is sold out but JustinHealth.com/glutathione would be where you can find that as the third natural site if not head over to EvanBrand.com or JustinHealth.com just put glutathione in the search and we have some of our own sulfur based compounds that we use in the lead As well mold based compounds we use so feel free to reach out to us, we’ll put pertinent links down below for you guys as well. And then outside of that, just really make sure you have good stomach acid levels because you need good stomach acid to break everything down. And then we also talked about, you know, the animal products if you’re vegan vegetarian, try to get some animal products in there, even if it’s egg yolks, or if it’s a little bit of fish, do your best on that and just try to make it healthy. And then really look at B 12. And fully, you’re not going to get enough b 12. On the on the plant based side, you really need animal products to get b 12. So if you are really plant based, you need to make sure you’re supplementing with the high quality methylated B 12. And maybe some activated full layers to be safe, because you need full eight and B 12 to run those glutathione pathways.
Evan Brand: Let’s just do like a quick 30-second recap because those with brain fog are like oh my god, what am I supposed to do? Do I go like swimming? Am I in a pool filled with glutathione? What do I do? So whey protein, grass fed meats Good cruciferous veggies probably lightly steamed over raw, maybe some greens powders or greens juices if you if you just for some reason can’t tolerate it like the broccoli sprouts, I think that’d be great for somebody that can’t eat broccoli because maybe they have digestive troubles and you could go for some of the extracts, making sure you’re doing enough vitamin C as you mentioned, adequate stomach acid, so making sure you’re testing your gut for infections. If you have H. pylori, and other infections, you’ve got to fix your gut, so possibly extra enzymes, possibly anti microbials, antifungal, anti parasitic herbs to treat the infections, maybe doing an oat test to check in on your overall levels and getting some micronutrient panels run. And then if there’s other issues that are keep depleting you then maybe looking into the mold, the heavy metals and the other toxins that are going to deplete glue to die on. That’s kind of your recap.
Dr. Justin Marchegiani: 100% now, what do you need for sulfur amino acids a day? I would say you know 1500 to 2000 milligrams on some of the NAC and some The sulfur aminos I’ll do one to two scoops, you know, 1020 grams of collagen a day, I think it’s great on the vitamin C on the low side, you know, one to two grams, I think it’s great if your diets amazing and you’re getting lots of leafy greens and some low sugar fruit, maybe a gram or nothing is probably okay, if you’re really great there, if not a gram or two on the vitamin C sides are great on the light bulbs almost go to file. And if you want to go that road, I think half a gram to one full gram is fine half a gram on the maintenance side. Or if you’re just getting sulfur amino acid, that may be enough. But if you’re under some stress with mold a half a gram to a full gram. And if you’re dealing with more acute stress, right, a lot of viral issues today can really create stress in the lungs and glorify them can be very helpful with that long stress. You may want to go up to two grams on the glutathione more acutely and those are a couple of good first things go ahead.
Evan Brand: Yeah yeah don’t forget about the NAC too. You and I did I don’t know if we did a whole show or if we just kind of rained it on it for a little bit, but NAC in regards to immune health and NAC being very very protective so I’m usually at around a gram but you could go higher possibly 2 grams per day of NAC combined with that 500 to 1000 milligrams glutathione that is an awesome one-two punch.
Dr. Justin Marchegiani: Yeah, just be careful what the NAC cuz it’s an expectorant it will dry out your sinuses and and your throat a little bit so it’s great if you’re really mucus ease but be careful if you’re getting too dry you may want to pull back on it. So just kind of know that NAC is awesome for a lot of the excess post nasal drip excess mucus but if you go a little too much you may get a little bit too dry in some of those areas.
Evan Brand: I can confirm. I haven’t had a nosebleed but when I was going higher like, two grams. Yeah I was pretty dry I felt like I could breathe better though, man I tell you my sinuses felt clean as a whistle.
Dr. Justin Marchegiani: Yeah, so if you’re getting over a cold and you got a little bit of post nasal stuff going on, NAC you should be one of the first things you go to in your medicine cabinet specially if you get that little bit of a nagging post nasal drip cough and they cease the first thing to hit.
Evan Brand: Yep.Maybe that some Exley or nasal spray something like that you got anything.
Dr. Justin Marchegiani: Oh yeah, well you definitely the sign is flush with the X clear like that’s number one, because you got to flush things up, and the number two, you dry it up and then you do those you’re in good shape. Anything else you want to highlight Evan?
Evan Brand: No, let’s wrap this thing up it was fun and if y’all have further questions or comments of course we always want to hear your experiments and your experiences- how did it go, what did you do with glutathione, did you do like me and then I called Justin in like 10 o’clock when I hey man I took like a double or triple dose of glutathione and I got a terrible headache I remember that so now. We’re always being the guinea pigs and that’s what we love doing and we are available clinically. So if you need help, you can reach out to Dr. J at JustinHealth.com, we work with people around the world. So JustinHealth.com, my website EvanBrand.com and we’ll be in touch next week.
Dr. Justin Marchegiani: And when we talk about these things guys, this isn’t theoretical for stuff. We see thousands of patients, tens of thousands over our decade-long careers and we know it works. We know it doesn’t and if you’re leaning into glutathione, maybe put a little bit of a binder in there an activated charcoal bentonite clay taking way away from food and supplements just to kind of soak up or kind of broom up anything that may be already liberated from your body. So that’s kind of a good first step just to be on the on the alert and always start low taper up don’t ever go over the top on it always start low work your way up try to make sure you’re working with a
practitioner so you have ways to monitor, test and assess as well as figure out the best order of operations and addressing your concerns. And if you want to reach out to Evan, EvanBrand.com, myself Dr. J JustinHeatlh.com. We are available worldwide for support and health consults and feel free and reach there. All right guys if you enjoy it let your friends and family know put your comments down below and what future podcast topics you’d like to hear about. Have a good one guys, take care.
Evan Brand: I got one final comment on that sure, I’m so glad you brought up the binder. So this podcast is not designed for people to go, hey I’m you know feverishly writing down everything that Justin said. This many milligrams of this is I’m gonna go do his protocol- no, that’s not what he said. These are just guidelines okay because if you go and you do a gram of glutathione and you’ve never taken it you’re probably gonna get a headache or feel like crap because you’re mobilizing things. This thing glutathione helps push and I think of it as the push so when we’re talking about a detox protocol it’s kind of a push catch push catch repeat and if you don’t have something in to catch it meaning something to upregulate phase 2 or potentially also in addition the binders like the charcoal the clay zeolite bentonite you know chlorella whatever it is you could get in trouble so please don’t just go to glutathione, you’ve really got to have some sort of catcher’s mitt in place or just help your you know allow your practitioner to guide you because you can have too much of a good thing.
Dr. Justin Marchegiani: Excellent point, Evan. We’ll put some of our favorite products down below so you guys can take a peek and we’re here to help you as needed Evan you have a phenomenal day.
Evan Brand: Great chat with you, take care. See you later.
Dr. Justin Marchegiani: Thanks, bye.
Top 10 Anti-Inflammatory Foods | Podcast #197
Welcome to a functional medicine podcast! In this video, Dr. J and Evan Brand discuss what the top 10 anti-inflammatory foods are, what nutrients derive from them and how essential can those nutrients be to our gut and overall health.
Keep tuning in for more videos to get the latest about what’s happening on the functional medicine world. Hit subscribe, smash the bell, and don’t forget to share!
Dr. Justin Marchegiani
In this episode, we cover:
02:34 Importance of Nutrients in Anti-Inflammatory Foods
05:35 Ways and Mediums for Foods to be Consumed
10:44 All About Priorities
23:54 Glyphosate Affects Glycine
28:10 Digestion Problem Epidemic
Dr. Justin Marchegiani: Hey, guys. It’s Dr. Justin Marchegiani here. Evan Brand, happy Monday! How are you doing?
Evan Brand: Happy Monday to you, man. I’m doing great. Summer’s going along fast. I mean, it’s already like mid-August now, and before you know it, it’s gonna be September, October, November. Then I’ll be complaining that it’s cold. So—
Dr. Justin Marchegiani: I know. Can you believe it, man? Time flies when you’re having fun. Any uh— fun stuff happen this weekend for you?
Evan Brand: Not— Not, I mean, every
Dr. Justin Marchegiani: Yeah.
Evan Brand: -saw a bunch of butterflies and— Oh! We did get chiggers on us. That was not fun.
Dr. Justin Marchegiani: [incomprehensible] chiggers are interesting. Yeah.
Evan Brand: It was two weeks— Not two weeks, two hours picking chiggers off of us. They were so small I had a little magnifying glass. You literally could barely even see it. At first, I thought it
Dr. Justin Marchegiani: Wow!
Evan Brand: It’s small. And so now, we’re all covered in chigger bites. But besides that, We’re doing good.
Dr. Justin Marchegiani: Excellent. Very good, man. Yeah. Doing a lot of water skiing this weekend, uh— enjoying Austin. It wasn’t quite as hot as it normally is in the summer this weekend so it’s pretty fun.
Evan Brand: That’s great. Yeah. you’re gonna— You’re gonna miss out on the uh— the water. I guess I have to revisit the water.
Dr. Justin Marchegiani: Totally. Absolutely. Well, let’s dig in, man. Let’s talk about our top ten anti-inflammatory foods. So we make a lot of recommendations to patients on, you know, certain foods, and— You know, we tend to follow like a Paleo template, right? And the Paleo template is nothing more than utilizing anti-inflammatory, nutrient dense, and low toxin foods. And we typically— Animal protein, the quality component’s also factored in, right? Organic, pasture-fed, you know, antibiotic-free, hormone-free. Animal products can have a lot of really great nutrient density, right? A lot of people that are plant-based, they kind of miss out on that. Do you know, uh— I got a lot of conversation to people on nutrient-density. So, for instance, 500 calories and grass-fed meat packs a lot of nutrition, right? You can get 500 calories of grass-fed meat in about eight ounces of meat, which is pretty reasonable, right? A lot of people, they’ll go out and they’ll get like a sev— you know, a six to eight ounce kind of Filet Mignon, or a bigger Rib Eye. Lot of good nutrients there. To get 500 calories of Kale, you got to consume 16 cups of Kale. That’s a lot of Kale! Most people would never consume that much. So the nutrient density is easier in some of these animal products, and it’s easier to get. It’s easier to access. Most people couldn’t do 16 cups of Kale in two days, let alone one day. But almost anyone could do eight ounces of grass-fed meat at one meal. And I’ll— Typically, if I go to a nice steak restaurant, I’ll even do— I’ll even do 16 in one meal for some good Rib Eye.
Evan Brand: Yeah. Let’s talk about why. I mean, why is it so important? You got to have these nutrients to—
Dr. Justin Marchegiani: Right.
Evan Brand: For one, you got to stabilize your blood sugar. And so, if you’re not getting good fats-
Dr. Justin Marchegiani: Uhmhm—
Evan Brand: -good proteins in, you must stabilize in blood sugar. And then, two, all the different-
Dr. Justin Marchegiani: Great.
Evan Brand: -micronutrients in amino acids that you get from your meats. Those go into fuel hormones, and neurotransmitters.
Dr. Justin Marchegiani: Right.
Evan Brand: So this is why like Vegetarians and Vegans, they come to us so often, but they a lot of times have a mental health issue, like an Anxiety problem. And it’s because they have no protein in. Or if they do have protein, as you mentioned, it’s beans. And then they have a bunch of digestive problems ‘cause they’re eating like cups of beans a day.
Dr. Justin Marchegiani: Yeah. So when we look at animals, right? Animals have a great ability to concentrate plant matter. So part of the reason why a lot of animal products can be superfood is because they concentrate plant matter. Number two, if you do organ meats— organ meats. If you look at like— Just Google like Vitamin A, you know, animal versus plant. I mean, you’re gonna see a lot of the plant-stuff. It’s— It’s beta-Carotene and uh— precursor compounds, right? These mixed Carotenoids, these beta-Carotene things, they have to get converted. Right? It’s not active Vitamin A. But if you get animal-based Vitamin A, whether it’s from Cod liver oil or actual liver— liver glands but they weren’t from good quality grass-fed meat, it’s already activated. So a lot of these nutrients are ar— already activated in animal-based forms. And number two, they’re— they’re concentrated, right? Part of the reason they’re concentrated is because the animals concentrate plant matter as they grow. If they’re— you know, if they’re like a natural kind of sustainably farmed type of thing, they’re gonna be grass-fed, and they’re gonna have access to it. We’re not talking about the CAFO feedlot thing. A lot of these, you know, documentaries, you’ll see like cow-
Evan Brand: Yeah.
Dr. Justin Marchegiani: -to make it work, right?
Evan Brand: Yup, well said. Let’s talk about gut real quick and then we’ll get into the food. So, if your-
Dr. Justin Marchegiani: Yeah.
Evan Brand: -gut’s
Dr. Justin Marchegiani: Uhmhm—
Evan Brand: You and I measured this on Stool testing. We look at levels of Calprotectin. We look at secretory
Dr. Justin Marchegiani: Right.
Evan Brand: And if your gut’s inflamed, you’re more susceptible to pick up infections. So bacteria and parasites, and worms, and everything else that we see, if you’re gut’s leaky because your gut’s inflamed because you’re eating inflammatory foods, that’s a big like Domino effect. And you could take all the herbs in the world to kill your infections but you have to have an anti-inflammatory diet at the base of it. Otherwise, it won’t work. I’ll just give an example. I did a case review this morning with some clients. And they’re vegetarians. And I’ve been really trying to get them to eat animal proteins but they won’t listen to me. The biggest foundation of their diet is grains. And we’ve looked at their IGA levels, and their IGA levels are still terrible. Now, we did clear some infections, but they have a bunch of parasites. And, I don’t think they’re be— gonna be able to heal their gut if they stay a hundred percent vegetarian. All they eat is like salad three times a day, and then they poop out undigested leafy greens. It’s like your body’s trying to tell you something, but they won’t listen. So—
Dr. Justin Marchegiani: E— Exactly, and that’s a really important component. We talked about some of these foods. There’s lots of different ways and mediums in which these foods can be consumed— soup, or smoothie,
Evan Brand: Yeah. Y— You got to do something.
Dr. Justin Marchegiani: Big time.
Evan Brand: Let’s dive in.
Dr. Justin Marchegiani: Alright, cool. So off the bat, I will just say, we’ll just kind of go into our animal products. I would say, grass-fed meat,
Dr. Justin Marchegiani: Totally. Totally. So, I’m gonna put the— I’m gonna put the
Evan Brand: Yup. I would add Avocados to the list while we’re talking about fats.
Dr. Justin Marchegiani: Yup.
Evan Brand: I do an Avocado, not
Dr. Justin Marchegiani: Uhmhm—
Evan Brand: …or Polyol reaction. I’m not sure what it was but uh— I believe isn’t Avocado a FODMAP?
Dr. Justin Marchegiani: It is. It’s a moderate FODMAP. It’s also a monounsaturated fat, so it’s a good one. It’s that good meme on the Face— Facebook I— I see a lot. It’s just great. It’s like an— an Avocado looking in the mirror like having a conversation with himself and he’s like, “You’re fat,” and then he goes, “But you’re a good fat.” [laughs]
Evan Brand: Exactly. I love that one.
Dr. Justin Marchegiani: [laughs] Is it a great little meme? So I like it. It’s a good quality fat.
Evan Brand: There’s a huge difference. Some may say a note about that. There’s a big difference even between certified organic eggs and certified organic pastured [crosstalk] local—
Dr. Justin Marchegiani: Yes.
Evan Brand: So like the Whole Foods Organic Eggs, the yolk is still pretty yellow, but we get these local eggs. There’s a pasture like 20 minutes from here. The eggs are— the yolk is so orange, you can’t even believe it. You’ve never even seen a yolk like that. So if you guys haven’t sought out a local farm, go on the website Eat Wild. Just Google “Eat Wild” or “Local Harvest” and type in your zip code and you can find all sorts of farms, and you could probably find farmer’s markets where you’re gonna get legit— legit quality.
Dr. Justin Marchegiani: Totally. And— And Joe Salitan who runs Polyface Farm, he’s taking some of his pasture-fed organic eggs. He sent them to the lab, and he actually compared
Evan Brand: That’s amazing.
Dr. Justin Marchegiani: So I mean, it’s like, let’s say, you do spend twice the amount of money on something— Let’s say you don’t even get 20 times more. Let’s say you get three or four times more nutrition in certain parts. Is that worth it? I think so.
Evan Brand: Absolutely. Well— So I posted on my facebook page last week. I just put up a podcast with Stephanie Seneff all about Glyphosate.
Dr. Justin Marchegiani: Yes.
Evan Brand: It’s a really good episode. And I told people that of you’re not eating a hundred percent organic, that you’re slowly killing yourself. And the lady said that— that I was in an elitist and I was an
Dr. Justin Marchegiani: Yeah. It hits a lot of people’s hot buttons because it’s— the argument really is about priorities. Right? It’s w— where things are more important, money tends to go, right? The problem is, there are a lot of people that kind of have an entitlement, where they expect optimal health but they want to put zero time or money towards it.
Evan Brand: Yeah.
Dr. Justin Marchegiani: And like if you read Micheal Paulins book— I think it was The Omnivore’s Dilemma. He talked about the amount of money that we use to put towards our food in the 1950’s. It was about 18% of our daily income— or our yearly income. And then, today, it’s been down to 9%. So what does that mean? We’re allocating 50% less of our resources to healthy quality food. I think that’s part of the reason why, you know, we’re sicker as a country, is that we want cheaper, more convenient food, which tends to be more processed and more inflammatory, and less nutrition in it. So there’s a sense of entitlement out there, and we’re just trying to fix the entitlement by, one, inspiring people and motivating them, and number two, giving them the education of like—alright, “Where can I get these things? Which foods are the best from a nutrient density anti-inflammatory stand point. And then piggybacking on that, the Monsanto had a big lawsuit. Uhm—They came back Friday night to take a 290,000,000-dollar lawsuit with this
Evan Brand: Yeah, well said, and so just to clarify for people, if something is not marked organic at your grocery, you can assume that it is sprayed with Glyphosate. We have millions— hundreds of millions of pounds sprayed in the US each year, and it really should not be called conventional food. I should really be called chemical, and then— So there’s the chemical section and then there’s organic. It shouldn’t be conventional because that’s not conventional. Conventional was organic just a short time ago. Now, organic has to be labeled organic but-
Dr. Justin Marchegiani: Yes.
Evan Brand: Your grandparents ate conventional in the
Dr. Justin Marchegiani: Right.
Evan Brand: -didn’t exist.
Dr. Justin Marchegiani: And here’s the— he’s part of like the reason why a lot of this stuff’s skewed. RIght? If like, you’re Monsanto, and you’ve invested billions of dollars into a product, and you’re researching the product, what are the odds are that you’re gonna come up with negative information— let’s just say, shutting down this product, like sho— like showing that it’s negative and bad and harmful? Now, again, a perfect world would happen is, it would— you may— you may kind of like, you know, manipulate the study a little bit. A lawsuit like this happens and then, it sends a signal to every company. “No. We got to be really careful because we don’t want to be shut down with a massive lawsuit like this that would cripple a company. . Number two is, if I’m like, you know, Josh Mo, scientist at a university, and I want to do a study at this— looking at the safety of Glyphosate or Roundup, how do I get the ability to do a study on that? I have to license that product, that chemical, from Monsanto. Would you think Monsanto’s gonna license that product to me to use in the study? Probably not. This is what becomes, This becomes really hard to— to know the safety of some of these things, where it’s a little bit more ay, easier to do a study on Vitamin C, or an herb because there’s no major patent or massive company behind it. So it’s easier to study nutrients and herbs because it— they’re just out there in nature. There’s no patent on it. No one has exclusive rights to it. So I think it’s easier to believe some of the plant or nutrient or vitamin-based research out there. But when you have a licensed product that people have invested billions into, it’s harder to get unbiased research on those compounds.
Evan Brand: Yup. Agreed. So, eat organic is the goal. Check out the podcast with Stephanie because it will make you just really
Dr. Justin Marchegiani: Totally makes sense, and we a little kind of— We went off the— the beat and path here for a sec but I think it’s important to highlight this because if foods have these various residues, even if it’s on our top 10 list here, it may not be a good food for that.
Dr. Justin Marchegiani: Little different, yeah.
Evan Brand: Yup. Go for organic.
Dr. Justin Marchegiani: You can make that claim. There’s a little more behind that claim.
Evan Brand: Let me say a couple things about coconut. You mentioned coconut oil. I would tell people too. If you— If you like it, or if you’re looking for a swap, and you’re not doing well, with like Almond milk or if you’re still drinking conventional milk, coconut milk, you can do
Dr. Justin Marchegiani: Totally. Now, let’s go onto some various herbs that we can add
Evan Brand: Yeah, that’s great. I would say Cinnamon would be one to add to the list, too, of things you should have.
Dr. Justin Marchegiani: For blood sugar too.
Evan Brand: Yeah. I love using Cinnamon to help with stabilizing blood sugar. There’s actually-
Dr. Justin Marchegiani: Uhmhm—
Evan Brand: -some blood sugar supplements that have Cinnamon as an ingredient, so that show you how powerful it can be, not only as a spice or a
Dr. Justin Marchegiani: Absolutely. Let’s go into some various nuts and seeds. I mean, there’s some really good seeds. Chia seeds are great. They have really good Omega-3 content. Omega- 3 is that anti-inflammatory
Evan Brand: ‘Cause you’re avoiding the conversion process, you’re saying?
Dr. Justin Marchegiani: [crosstalk] Yeah. you’re bypassing the conversion process when you’re doing animal products. When you’re doing plant, there is a conversion process. Now, the less inflamed you are and the more Insulin-sensitive you are, the more you can convert that. So there’s an enzyme called delta-5 desaturase. Should it delta-5 or
Evan Brand: Makes sense
Dr. Justin Marchegiani: Very high in Zinc.
Evan Brand: -feeling so good with pumpkin seeds. I found a brand that’s organic, just a little touch of salt on them, and I do great with those, and most people can tolerate those quite well.
Dr. Justin Marchegiani: Excellent. Very good. Now, if we go to some of the fruits, I mean, I would go to the more nutrient-dense lower sugar fruits ‘cause high sugar in— in higher forms can be inflammatory just because it increases Insulin, and it causes these Advanced Glycation End Products. So we got to be careful with the sugar component. So I would say things like
Evan Brand: I would throw in the Citrus a bit too. Some Lemon, some Limes could be great.
Dr. Justin Marchegiani: Yes.
Evan Brand: I do that in the morning. A lot of people say that they just don’t have an appetite to drink water, or just, they don’t like the taste of it or something, so they just don’t drink much, especially a lot of teenagers that I work with. So I just tell them, “Make a little homemade Lemonade. Do a dash of Stevia or Monk Fruit, Lime, Lemon, and drink it, and that can be great. There’s a ton of benefits to that. And even some of the heavy metal detox protocols that I’ve learned-
Dr. Justin Marchegiani: Uhmhm—
Evan Brand: -the companies recommend that the client drinks Lemon to help during the process, so that’s pretty cool.
Dr. Justin Marchegiani: Totally. Absolutely. Is there anything else? So then we also have like our green vegetables. And then again, a lot of these green veggies are gonna be very high in Sulforaphane, uh— Diindolylmethane,
Evan Brand: Yeah. And we weave and use Broccoli extract in some of our protocols, so there’s actually really, really good solid evidence on the helping with Estrogen metabolism. So if you’d have any type of uh— Phthalate or plastic PA type exposure, which everyone has, then Broccoli extracts, or just eating Broccoli or Broccoli sprouts are awesome. I have a friend who actually makes a lot of different sprouts. He grows them and sells them at the farmer’s market, and people loved that stuff, and they feel so good.
Dr. Justin Marchegiani: That’s great. That’s great. And also say, uh— bone broth and/or organ meats, kind of put them on the same category ‘cause they’re more like
Evan Brand: So— Yeah. It— I believe the— So the Glyphosate, it is uh— I believe it’s a Glycine molecule that has something extra added to it. So, it replaces a Glycine. It’s like the body thinks that it’s Glycine but it’s not, so that’s why it’s so dangerous.
Dr. Justin Marchegiani: But I imagine it may block some of the effects that Glycine would normally have on the body.
Evan Brand: That’s right.
Dr. Justin Marchegiani: Glycine has a lot of beneficial effects at helping to be a backbone for Glutathione, so I imagine that Roundup or Glyphosate probably decreases Glutathione function. And I imagine it probably decreases the enterocytes that line our gut, ‘cause I know there’s research that in— increases gut permeability. I know Glycine’s really important for gut function. Correct?
Evan Brand: Yeah. That would be the mechanism. She did talk about that. How it does— not only does it increase the leaky gut situation but it also increases blood-brain barrier permeability, too. So, if you have a leaky gut, you have most likely
Dr. Justin Marchegiani: And we’re getting some questions in here that are inquiring about like, “Oh! If I get Glyphosate toxicity, what will I do?” I mean, I would say, liposomal Glutathione is great and/or just a lot of the Sulfur amino acids to make it. So, like, we have products that we use that give concentrated Sulfur-based amino acids like Glycine, Glutamine,
Evan Brand: Yeah. So, uh— Samuel had asked about a product form Zach Bush called Restore. I’ve had clients who’ve been taking Restore for over a year. I tested their levels of Glyphosate. These were people who said they’ve been eating organic, so we know they’re getting no new exposure to Glyphosate. They’re not using it around the house, and they’ve been taking Restore for a year. Their levels wer— we’re still off the charts. So I’m not convinced. I know he’s done some research on— on his own about gut permeability, which is awesome, but I’ve seen the data firsthand, testing people, and Glyphosate levels are still high. Now, I don’t know what their levels were like before they started that product. So maybe their levels were—
Dr. Justin Marchegiani: [crosstalk] It could have been higher.
Evan Brand: …higher.
Dr. Justin Marchegiani: Exactly.
Evan Brand: And maybe it reduced it 10 times, so I’m not against it. I think it’s in the category of things that might help. Can’t hurt. But it’s not the ultimate cure-all. I talked with Dr. Shaw. He says sweating is key, and then Stephanie said that Fulvic acid is one of the best binders to— to soak it up and so I’ve been using a couple different tinctures lately to help with heavy metals, and it happens to have Fulvic acid in it. So, that’s kind of the go-to.
Dr. Justin Marchegiani: That’s excellent. So, in general, a lot of the Sulfur amino acid compounds I think are good to help with Glutathione. Uh— I think getting liver-
Evan Brand: I want to say the last food, and it’s sweet potatoes, and it’s because everyone is against-
Dr. Justin Marchegiani: Mm—
Evan Brand: -Carbohydrates so much, and sweet potatoes changed my life. When I had adrenal problems, I was going so low carb, and I couldn’t handle the stress of it. I believe my— my adrenals may have been just too weak to adapt to Ketogenic— maybe I’m wrong, maybe there was something else and my gut infection’s weakening me, but when I just added in a small sweet potato, just a couple times a week, that was the— Carb read feed at dinner time that I needed to really help me-
Dr. Justin Marchegiani: Yeah.
Evan Brand: -sleep better. And then once I slept better then I had more energy during the day.
Dr. Justin Marchegiani: Yeah, and I think, you know, we got to look at your situation as you’re definitely leaner and more Insulin-sensitive. So, just remember, if you’re an Insulin-resistant individual, right— uh— maybe a little bit overweight,
Evan Brand: You’ve got Vitamin A.
Dr. Justin Marchegiani: Uhmhm—
Evan Brand: You’ve got Vitamin B5, B6—
Dr. Justin Marchegiani: Potassium, uhmhm—
Evan Brand: Yeah, Potassium, Riboflavin— I mean, there’s a lot of good B’s in your sweet potatoes. I want to hit this question up, and I didn’t mean to distract if you have something else to say, but there was a question, or just a comment, from Gary, and he mentioned that the dilemma is you talk to the cardiologist nutrition people and they
Dr. Justin Marchegiani: Jack Wolfson, yup.
Evan Brand: He’s a Board-Certified Cardiologist. Guess what he’s dietary protocol is for all of his patients. It’s Paleo. It’s a Paleo template, and he reverses heart issues with the Paleo template. So you can’t pay attention to the conventional nutritionist that are trained by big Pharma.
Dr. Justin Marchegiani: And just remember, when we— when we talk about any dietary advice, we don’t talk about
Evan Brand: Yup.
Dr. Justin Marchegiani: And that template allows us to take meat and bring it
Evan Brand: Right. Yeah, well said. Uh— There was uh— comment here from Eva that you probably like to hear. “Hi, Justin. Wanted to say my nightly light cramps are gone since I started to take magnesium malate three times a day. That’s cool.
Dr. Justin Marchegiani: That’s great. Really cool. Excellent.
Evan Brand: Has a question here about Charl— from Charlie, “Grass-fed beef but grain-finished beef still optimal?” No, it’s not. You want a hundred percent grass-fed, grass-finished. They do the grain at the end because it helps to add some fat and marbling to it, but I, personally, like grass-fed and -finished.
Dr. Justin Marchegiani: Yeah, I mean, if you don’t have the ability to get that because
Evan Brand: That’s a good point.
Dr. Justin Marchegiani: Uhmhm—
Evan Brand: There’s a good question from another person. My son had GALP He eats grass-fed meats, organic chicken. He’s Gluten dairy-free. Any thoughts?
Dr. Justin Marchegiani: Uuuhm— Who’s
Dr. Justin Marchegiani: Okay. Got to— I’m trying to find that question.
Evan Brand: It was near the top.
Dr. Justin Marchegiani: Okay, got it. Uhm— So in general, I would just say first, goat tends to be driven up by fructose. Okay? So, fructose can get converted to Uric acid. And again, it’s Fructose. We had a lot of questions about this. So, like, “Dr. J, what’s— what’s Fructose? It’s Fructose.” No, it’s not. It’s Fructose. I got a big conversation with Dr. Robert
Evan Brand: I’ll just start saying it like you then. I wouldn’t say Fructose. I’m gonna have to correct myself now.
Dr. Justin Marchegiani: Yeah. Oh, he was like, “Dude, it’s Fructose.” I’m like, “Alright. I’ll say Fructose from now on.” Uhm— But in general, with Fructose, that can be the big driving factor of Uric acid, alright? That can be the big one. So, they may need to go. They may need to decrease some of the Purine-rich meat to start, so a lot of the Purine-rich meat may be the organ meats, may be the higher fatty meats, in the meantime, while they get the carbs down and they cut the fructose down beneath like 12 to 15 grams per day. And then—
Evan Brand: And then grains too, ‘cause she said gluten-dairy free but she didn’t say [crosstalk] grain-free.
Dr. Justin Marchegiani: Of course, grain-free— all that. Get all that stuff out of there. I’d even do nightshade-free as well, and make sure the Carbs are very low and the Fructose— the Fructose is low as well, below 13 grams. And then start from there.
Evan Brand: And alcohol. I’ll get rid of alcohol if they’re doing it. There are people could, “ Oh! I’m organic, gluten-free!” And then they drink two glasses of wine at night.
Dr. Justin Marchegiani: Exactly. Yup. So I would start with that and then I’ll— the alcohol as well, and then see how it goes.
Evan Brand: Alright, let’s keep going here. Thanks for the feedback, Mary Anne. Uh— Did you see any other questions? I think that was most of them. We— We hit Samuel. He was asking about the supplements to eliminate Glyphosate. I commented on that already. And then, Em-Em here. Do you know of a good d— desiccated glandular supplement?
Dr. Justin Marchegiani: So desiccated glandular— So it’s got to be— So it’s got to be porcine. So for my thyroid support, thyroid balance, I have one. It is— It’s got some active thyroid constituents in there, so it’s something I only recommend to someone that needs it and has lab testing to support it. So, that’s a good product but it wouldn’t be necessarily recommended in unless there’s Lab Testing saying that you need it.
Evan Brand: Yeah, good point.
Dr. Justin Marchegiani: Yeah.
Evan Brand: Uh— Last question here form Roshan, “It’s becoming evident. My Hypochloridia’s due to
Dr. Justin Marchegiani: Yeah. So, number one, just getting the stomach acid and the enzymes up
Evan Brand: [incomprehensible] will work better, you’re saying?
Dr. Justin Marchegiani: Yeah. It will make it work better, I mean. So, they’re saying that the pyloric sphincter— so that’s the sphincter that goes from the stomach to the small intestine. Uhm— That is opening up soon. So I would just get the food digested better. You could always throw some bitters in to help as well. But I get that sphincter working better by getting the right pH there, and that tends to help in obviously like the low-hanging fruit, like not eating when stressed and such.
Evan Brand: Yeah. Not eating in a rush-
Dr. Justin Marchegiani: Uhmhm—
Evan Brand: -not scrolling on Instagram while—
Dr. Justin Marchegiani: Chewing your food up enough.
Evan Brand: Yeah. A lot of people have terrible eating habits. You know, my clients, I tell that I want them to eat in peace and they laugh and say, “But that’s so boring.” It’s like, what are you doing then? And they’re like watching TV, playing on their phone, reading the newspaper, and like in an argument with their friend, all at the same time while they’re eating. It’s like, “No wonder we have a digestion problem epidemic.”
Dr. Justin Marchegiani: Yeah. I mean, I would just say, if your digestion’s better and good and you’re feeling good after your meals, you can obviously cheat a little bit with some of those recommendations. But if your digestion’s not good, then you want at least give yourself that 10-15 minutes of peace.
Evan Brand: It’s easy.
Dr. Justin Marchegiani: Uhmhm—
Evan Brand: Five minutes before the meal, chill out. Five minutes after— you know, try not to rush through the meal.
Dr. Justin Marchegiani: Yeah. And then, what can help a Hiatal hernia is on— one, there’s some
Evan Brand: I had a Hiatal hernia one time, and I think it just disappeared ‘cause I’m not bothered by that part of my—
Dr. Justin Marchegiani: [crosstalk] Yeah.
Evan Brand: I don’t feel anything anymore.
Dr. Justin Marchegiani: It could have been infection-based. So let’s kind of summarize a lot of the foods. And again, in no particular order just ‘cause
Evan Brand: Pumpkin seeds. Don’t forget—
Dr. Justin Marchegiani: Pumpkin seeds. Pumpkin seeds. Is there anything else you wanted to add to that list, Evan? I think good quality hydration.
Evan Brand: Uhmhm— Don’t skip out on that. A lot of people do a lot of teas and a lot of coffee because they don’t do Soda, which is great, but you can’t skip the good
Dr. Justin Marchegiani: Totally.
Evan Brand: Organic coffee all day, great! But, okay. You got to drink water, as well. How simple.
Dr. Justin Marchegiani: Bingo! I guess that’s excellent, Evan. Well, hey! Today was a great podcast. Appreciate everyone listening. Head over to thyroidresetsummit.com. We got a Summit coming out, end of the year to probably be in January. We’re moving it back a little bit to get more great speakers involved in the summit. More time here. And, Evan, anything else you want to say? I would just say give us a thumbs up. GIve us a share. You know, hit the— the bell as well so you get the alerts to these great talks so you guys can be involved and connected. Anything else, Evan, for you?
Evan Brand: Uh— People can reach out if they want to. Schedule a consult with you, your site. And they also— you also have those supplements mentioned on there. The Curcumin Supreme. That’s at justinhealth.com. And then, if you want to check out my site, consult with me, evanbrand.com. We love helping you all. We really appreciate the feedback. Take good care of yourselves.
Dr. Justin Marchegiani: Evan, you have a great day. Everyone out there, have a phenomenal week too.
Evan Brand: See you later.
Dr. Justin Marchegiani: Bye now.
Evan Brand: Bye.
The Omnivore’s Dilemma, Michael Paulin’s book