Skin Health and Autoimmunity | Podcast #202
The skin is a window into what’s happening in the gut. While it is true that a lot of potential skin irritants are everywhere, one might try to consider that everything going on on the inside is reflected on the outside.
Watch the video and learn about skin issues, effects of gut health to skin, autoimmune conditions, and effective ways and preventive measures to make the surface reflect the way we wanted it to be.
Dr. Justin Marchegiani
In this episode, we cover:
01:00 Gut health mirror the skin
06:09 Administer nutrients inside-out
11:02 Topical irritants
15:27 Bowel movement affects skin health
17:48 Histamine issues, genetics, and excessive insulin
20:38 Autoimmune domino effect
Dr. Justin Marchegiani: Hey there it’s Dr. Justin Marchegiani, hope you all had a fabulous weekend. I’m in a house here with Evan Brand. Evan, how we doing my friend?
Evan Brand: Happy Monday man. Hey look, I was talkin’ about the sunny weather but I’m gonna complain today it’s rainy and grace guys so, today is a good day to just
Dr. Justin Marchegiani: Hey, that’s wonderful man really good idea. Well, I’m excited to dig in today in this topic of Skin Health and Autoimmunity.
Evan Brand: This is huge!
Dr. Justin Marchegiani: Yeah it’s a powerful topic. I mean, we know that the immune system and the gut are intimately connected ’cause about 80 percent of your immune cells live in your gut and the MALT and the GALT the–
Evan Brand: Yeah, I’ve got some statistics here. Was a good way to open up. This is from the CDC; this is actually 6 years old so it’s probably even
Dr. Justin Marchegiani: Yeah.
Evan Brand: –it was all the dysbiosis in my gut. So, we’re definitely gonna chat about that today too about infections.
Dr. Justin Marchegiani: Yeah, you even have a lot of rosacea too which is a sign of inflammation on the skin. Now, that’s important because when I see someone that has some kind of a skin issue that tells me that there’s some type of autoimmune or internal inflammatory thing happening inside the body especially the gut. So when I see skin issue the first thing I look at is potential food allergens. And we would move someone to like a paleo-slash-autoimmune-paleo template. And then we know other nutrients are really important so if we have poor digestion the chance of us breaking down fat-soluble vitamins like Vitamin-A go down. We know the ability to digest and absorb and assimilate zinc goes down. Healthy fish oil fats like Omega-3 go down. Vitamin-C which is really important for that collagen matrix goes down. Biotin which is a– uh–
Evan Brand: Yeah I was gonna say let me take you down to zinc rabbit hole a little further ’cause this is really important based on my history–
Dr. Justin Marchegiani: Uh-huh.
Evan Brand: –the skin issues. I had H-pylori, I showed up positive with a– on my second test on my stool. I first showed up a parasites, cleared those out. Second round on the re-test, you know, Justin I see this every single week on lab results, you know, sometimes we clear out a client’s gut of some infection, and then on the re-test a new infection shows up. And that’s what
Dr. Justin Marchegiani:Yeah, I mean you have your antibiotics, you have your immunosuppressants, you have your
Evan Brand: Oh my gosh.
Dr. Justin Marchegiani
Evan Brand: Oh and here’s the thing I wanna point out: you have to do both. You’re talking about– okay, sure, do the topical stuff. Great. Instead of steroids, maybe do topical Vitamin-C serum, maybe some topical Vitamin-A. But you still always have to work
Dr. Justin Marchegiani
Evan Brand: Yeah.
Dr. Justin Marchegiani: If it manifest with psoriatic symptoms, right? Then that’s psoriasis if m– if
Evan Brand: Oh, and you tied it all together
Dr. Justin Marchegiani: Thank you! That’s it.
Evan Brand: See. So here’s the thing out there people realized: you can measure this stuff. We measured β-glucuronidase on every single stool test and here’s the really-really fun thing that Justin and I love so much about our jobs – is that within 6 weeks, we could see β-glucuronidase come down by 500, 600, a thousand points, you know. We may see someone at 3000 which is too high and this means, hey look, they’re recirculating not only hormones but could be toxins too that get conjugated as you mentioned. And so that’s not good and this is why someone has like a heavy metal toxicity problem but they have dysbiosis. You have to fix the gut too because to detox effectively, you’ve got to have that open-loop system, not a closed-loop system. So when we come in with probiotics in usually phase 2 or phase 3 just depending on what our protocol looks like, we’re gonna see β-glucuronidase drop. We’ll typically gonna use some enzymes, you mentioned the liver support; liver nutrients can help, sometimes methylation nutrients can help. Uh– one thing we forgot to mention so far about skin is the topical irritant, so why don’t we chat about that, like soaps, shampoos, conditioners, perfumes, artificial fragrances– oh my God! I should have took a picture– I could have put this on my Facebook page man, it would have went viral. These two girls, we were in Target, we were gonna take the baby in the Target to go look for something. I remembered what it was. And these two girls were in the parking lot, and I saw ’em with a huge bottle, and they were spraying each other and I thought, “Oh, what are they spraying?” And so I just say, “Oh, whatever”. But we get into the store, we’re standing right next to these girls, I thought I have to ask them what this is. I said, “Can I ask what you all are spraying on each other?” And they’re both, “Ha-ha-ha” they both giggled, and she goes “Get it, it’s in your purse show ’em”. And they pulled it out and it’s a giant bottle of Glade air freshener, apple cinnamon scent. And I just looked at it–
Dr. Justin Marchegiani: Oh my gosh!
Evan Brand: –[laughs] I just looked at it and I was like, “So you’re all using air freshener as perfume?”, and they’re like “Yeah!”, and I was like, “Okay”. I should have said, “Can I take your picture that’s so cool and then post it online or something”. But I
Dr. Justin Marchegiani: Yeah, it’s like a warning right? Hey, do not take this.
Evan Brand: –so I mean, we could go into the reasons I– on my– if you just look up uh–
Dr. Justin Marchegiani: Uh-huh.
Evan Brand: If you just google “Uber fragrances ban” or something, you can read it. I did a whole like 20 different studies on my– on my petition about the different artificial fragrances and the phthalates and all that endocrine-disrupting things in those so, I mean, please don’t spray yourself with air freshener that’s just insane.
Dr. Justin Marchegiani: Yeah it’s a whole bunch of junk in there and a lot of these things, you know, if you’re female, a really big concern because you have a hormonal rhythm to your– to your monthly cycle and that can easily be disrupted. Men as well, because men, you know, they’re hormone rhythms more flat line but there’s a lot of Xenoestrogens in the environment from plastics to pesticides to fluorides,
Evan Brand: Yup, so not to go too off of that topic ’cause you were– you were going somewhere good–
Dr. Justin Marchegiani: Yeah.
Evan Brand: –but I just wanna restate. Make sure you clean up all your personal care stuff. It could be your lotion, it could be like I said, shampoo, conditioner, you can go on the environmental working group and you can look on there. Uhm– Justin also likes the skin deep uh– reference, you can just–
Dr. Justin Marchegiani: It’s the same thing– it’s a different branding, yeah–
Evan Brand: A different branding, okay.
Dr. Justin Marchegiani: Yup. And I– I use a brand called Marie Veronique, she’s a great brand– she’s a great
Evan Brand: Yeah.
Dr. Justin Marchegiani: –it’s one product I think that comes out really good. They have a patients telling me they have a good ___[14:25] I think it’s a moisturizer. But just take a look at it and see. And
Evan Brand: You gotta poop folks.
Dr. Justin Marchegiani: And that’s gonna be then be pushed out the skin, right? The solution to pollution is dilution, and, your skin is a mirror of what’s happening in your gut.
Evan Brand: And then also the solution is pooping, ’cause if you’re not pooping, you’re gonna have skin issues. I’ve– I’ve– I’ve literally seen people improve their skin issues just by pooping from once every 3 days, to pooping every day, their skin got better just by giving them some herbs to help things move along a bit.
Dr. Justin Marchegiani: Yeah, and if your skin is excessively dry across the board, I always look at essential fatty acid intake, as well as digestion like–
Evan Brand: Oh yeah.
Dr. Justin Marchegiani: –number one, are we getting enough of these good fish oils, uh–
Evan Brand: Yup, well said. Your poop has to sink. It’s very common. I mean, 90% of the time when we run a stool test on people, we’re gonna see elevated
Dr. Justin Marchegiani: A hundred percent.
Evan Brand: What’s the high stew scene on
Dr. Justin Marchegiani: I’ve seen it
Evan Brand: Okay, okay.
Dr. Justin Marchegiani: And these people are you know– you know, they’re having– they’re reporting back, “Hey how are your stools looking?”. “
Evan Brand: Yup. The only of the thing I wanted to mention was the histamine issue, and, makes that– we’ve hit on this another podcast but that with uh– gut bacterial, like bacterial overgrowth that does mess up your ability to break down histamine from the diet. So that’s why some people say, low histamine diets help. But that’s still not the root cause. It’s just that those malabsorption and dysbiosis issue causing you not to digest your histamines or break ’em down rather.
Dr. Justin Marchegiani: Correct. So, when you wanna– when we get deeper into like the diagnoses, just remember, the diagnoses is a manifestation of inflammation and how that inflammation is presenting itself. Inflammation that presents in certain ways gets classifieds as one condition, versus another. A lot of times the underlying way to go about it is
Evan Brand: Yeah, well said. And then the
Dr. Justin Marchegiani: The genetics.
Evan Brand: –and then the genetics are always, you know, they’re– they’re
Dr. Justin Marchegiani: Yup, a hundred percent. And then a couple things you can see too is–
Evan Brand: Ahh.
Dr. Justin Marchegiani: –so if you’re doing a lot of insulin lot of modifying carbohydrates you can see the
Evan Brand: Yes.
Dr. Justin Marchegiani: –it’s like
Evan Brand: Yeah my uh– my brother-in-law, it’s my wife’s sister’s husband, he’s got a triple AMI. He’s got type-1 diabetes, he was diagnosed as a teenager, then he went on to develop Hashimoto’s, then he went on to develop Alopecia. So once the autoimmune domino effect starts to happen, you can start to rack up the autoimmune diseases and that’s why some clients come to us and like, “Look, I’ve got six different autoimmune diseases at the same time.” It’s the same thing. Once that leaky gut takes place
Dr. Justin Marchegiani: Yeah, and also excessively pale skin. We– that could be an anemic, lo– low B-12 and or Iron. And there could be
Evan Brand: Yup, well said.
Dr. Justin Marchegiani: Well, any other issues you wanna address here. Of
Evan Brand: So here’s the thing that I just found out. Uh– a couple of weeks ago is that Yasmina– is– she’s no longer alive.
Dr. Justin Marchegiani: What happened?
Evan Brand: She passed away a few weeks ago.
Dr. Justin Marchegiani: I didn’t know that.
Evan Brand: Yeah. If you go on– I think it was on her Facebook page. Uhm– and then I saw her uh– whole– her obituary is to– she’s the healing histamine check, right? Yasmina Ykelenstam, sounds like that?
Dr. Justin Marchegiani: Yeah.
Evan Brand: Yeah, yeah.
Dr. Justin Marchegiani: That’s really sad.
Evan Brand: Uh– it was breast–
Dr. Justin Marchegiani: [crosstalk]…last year she was really ___[23:14] and healthy.
Evan Brand: It was breast cancer; it says her on the– on the uh– obituary. She was 43.
Dr. Justin Marchegiani: Oh that’s really sad.
Evan Brand: That’s amazing that you got to chat with her.
Dr. Justin Marchegiani: Yeah well, I– I send my condolences to her family. That’s– that’s really sad, but she had a lot of great information that she provided and I’m hoping that, you know, she was able to help thousands of people during her–
Evan Brand: Right now hopefully her legacy will continue on.
Dr. Justin Marchegiani: Yeah. Absolutely.
Evan Brand: Well, good. We gotta wrap this thing up but check out justinhealth.com. If you wanna reach out to Justin, you can get help around the world. Doesn’t matter where you are. So justinhealth.com, we can help you figure this stuff out. If you wanna reach out to me, you can check out my site, evanbrand.com. We always love your comments, your feedback. And we look forward to helping you soon.
Dr. Justin Marchegiani: There any questions you wanna answer here Evan, I know, we kind of really, you know, on time constraints. Other than that, you saw that you wanted to highlight?
Evan Brand: I didn’t see any.
Dr. Justin Marchegiani: Okay. I think we’re on the right track here. Uhm– anything else you wanna say?
Evan Brand: Not today, just– get– get help. Don’t give up.
Dr. Justin Marchegiani: And I’ll be back here later on this week guys for a live Q and A, so we can get some more questions and answers. I may even jump on today if I can if I have time. But you all here make sure you subscribe, give us a thumbs up, give us the share, give us the bell. And we will all chat real soon. Have a phenomenal day.
Evan Brand: Take care.
Dr. Justin Marchegiani: Take
Trends in allergy prevalence among children aged 0–17 years by asthma status, United States, 2001–2013 Study
Epigenetics And Why You Are Not A Slave To Your Genes
By Dr. Justin Marchegiani
You are not a slave to your genes. We see all kinds of information on the news today about Angelina Jolie getting a preventative mastectomy, which is removing healthy breast tissue.
She tested positive to the BRCA1 and 2 gene, this is a genetic risk factor for breast cancer.
The question that I purpose is why are there millions of people out there that have this gene and aren’t coming down with breast cancer?
It’s because, genes are not a death sentence. You have the ability to control how your genes are expressed, in regards to how you manage stress.
Essentially, genes are like a light switch; You can flip it on or off based on how you manage stress and it’s the factors above the genes, known as epigenetics (These are the switches that are above).
It’s kind of like you see a puppet and the puppet moves but it’s the marionette above that’s controlling the puppet. It’s the epigenetics above that’s controlling the DNAs, flipping it on and off.
Many different people in different families know that they have a predisposition to heart disease. Their father died of that or their uncle died of that. We see it with cancer in different families as well.
Yes we passed down lots of traits and skills through generations in regards in how to eat and how to manage stress and such. These can play a factor in why these are passed down.
If we don’t manage our stress properly that turns on certain epigenetics, which flip genes on or off.
So the next question is how do we control these?
Predisposition, stressing our genes is nothing more than pulling the chain tight. Each link in the chain may be a predisposition. If I pull the chain tight, the heart disease link may break, maybe cancer on another, or fiber fibromyalgia MS on another person.
So the question is, let’s take the stress off the genes (let’s take the stress off the chain). Pulling these chains tight gives us the predisposition for these chain links to break; lessening the stress decreases that chance.
Essentially, we have three main stressors. These stressors can be physical, chemical, and/or emotional stressors.
Physical can be an old car accident, it can be too much too little exercise, old injuries, and traumatic events/physical traumatic events. Chemical stressors can be infections, food allergens, eating poorly, getting exposed to environmental toxins and heavy metals. Emotional stress poor communication in relationships, financial issues, issues with children or your spouse or loved ones.
These are all issues that can affect the emotional side and all of the stressors actually interplay on one another. So what that means is you may have hurt your back in an old athletic injury, an old sports injury. That’s going to decrease your body’s ability to function and do things like maybe golf, or do things that you enjoy.
Then you’re going to have an emotional heart ache now because you’re not going to be able to do some things that used to do and then we have all kinds of inflammation which is a chemical stressor from the injury. So if physical stress becomes a chemical stress which becomes an emotional stress, then all of these stressors interplay on the genes.
If we don’t manage those stressors properly then our genes are going to frown, we’re going to see a frowning face. If our genes are managed properly, we are going to see a smiley face. The goal is we want to make genes smile as much as possible.
So getting back to our genetic predisposition analogy, our predisposition is which link may break. But again, if we don’t pull the chain tight we don’t have to worry about the link breaking because the stress isn’t on there to make it break in the first place.
So manage the stressors, by taking the stress off the chain, by taking the stress off your genes. You have the ability to control this.
Going out there and preventatively removing healthy organ tissue is absolutely preposterous. A lot of people do this because they get caught up in the fear of it, they feel like they don’t have control. They feel like it’s a death sentence and I want to make sure that everyone knows that it’s not a death sentence.
You have the ability to control your genes.
So in the analogy of Angelina Jolie and cancer, vitamin D is a perfect analogy that can decrease cancer risk amazingly. Decrease sugar and refined carbohydrates, eating organic, managing stress, getting good sleep, moderate amounts of exercise, and eating cruciferous vegetables; broccoli, asparagus, kale (they’re high in these different cancer metabolizers).
These are all simple things that you can do that can take the stress off your genetic chain. You may have to do a better job at managing stressors than the average person, but you still have the ultimate control to help your genes express optimal health.