Detox with the Correct Binders | Podcast #324

Dealing with toxic substances can be an overwhelming experience. With that in mind, it helps when things are simplified and made into relatable terms. Intestinal binders are a crucial part of any detox protocol. When the liver processes toxins, they get excreted through bile and into the small intestine. If the toxins are not bound to anything, most of them will get reabsorbed in the gut.

It is important to note that certain health conditions may make binder types more or less desirable. Having a good practitioner help determine those choices for you is always advisable. Also, there are some circumstances, such as in autoimmune disease and infectious conditions, that require the use of precaution and targeted choices with binders. Proper sourcing is critical as with all supplements, as each of them can come with unnecessary risks if they are not high-grade/quality. 

Binders are like free hall passes! In using a binder, your body is spared the work required to process a toxin through the liver and gallbladder and is, instead, excrete from the body. Check out this podcast to know more about what suits you!

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

0:18      How Binders Work

8:38      Binders’ Mechanism

15:11     Detoxifying

21:20    Different Kinds of Binders

29:44    Detox as a Side Effect

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Dr. Justin Marchegiani: We are live. It’s Dr. J here in the house with Evan brand. Today we’re gonna be talking about using binders to help detoxify, exciting podcast because we are utilizing all the things that we are chatting about with our patients every week. And we’re excited to share with everyone else, some of our natural strategies, Evan, how you doing, man? 

Evan Brand: I’m doing really well excited to dive into this. This is something that you and I got into several years ago. And it’s been really helpful for our practice, because we’ve been able to take people that were not tolerating protocols, and then we were able to get them to tolerate the protocol. And so when you’re coming in and working on something like gut infections, whether it’s h pylori parasites, bacterial overgrowth, Candida, sometimes, if people have been sick for a really long time, they may not tolerate the protocol we’re giving them. And that doesn’t mean the protocol that we’re giving them is incorrect, or there’s something wrong with it, or there’s an herb reaction or I don’t know, like a, you know, a supplement, it’s not working well for them. That’s not usually the case. In fact, that’s extremely rare. But what rather is happening is that the process of killing off these toxins, I kind of use the analogy of like a bad breakup. And when you’re kicking out the girlfriend, she’s taking off the pictures off the wall, and she’s breaking them and there’s a bunch of glass shards in the hallway as you kick her out. It’s not a clean breakup. And so when you’re killing off these bugs, they don’t want to die, they don’t want to leave. And so they may release toxins that make you feel bad in an effort to get you to stop killing them. Hence, that’s where binders will come in, and they’re acting as the janitor, and they’re going to come sweep up the glass shards that the bugs left behind. interesting way of looking at it. 

Dr. Justin Marchegiani: I like it, like the analogy that I typically give is imagine you got a trash barrel right in your home, well, it may not be a big deal until you go buy a whole bunch of groceries. Now imagine you got a smaller trash barrel. Well, once you throw it away the egg carton and all the other trash from everything else it’s going to overflow. And that overflowing is where you start dealing with die off. And a lot of people, people that are more sick tend to have smaller trash baskets to begin with. And so essentially giving yourself a bigger trash basket or increasing the frequency that we take it out, right, empty it out, is going to help. So I think either analogy works. So in general, I think the first thing I want to highlight off the bat is well, I like to prepare patients to get there you know, to get killing done in the right way. So I’m always working on hormones and adrenals and diet and blood sugar indigestion first, I find that is the most important component to all this. So an ounce of prevention is worth a pound of cure. So before you go in and start having to do all this killing and and use binders, first, get yourself ready for it. And most people do not like that they want to go in there and Kill Kill, kill, kill, kill, but preparations and be really important. 

Evan Brand: Yeah, and it sounds really attractive. And people, they get really excited when they find pathogens on a test. So we’re going to run a comprehensive stool panel, we’re going to run an organic acids test. And we’re going to be jumping on a call with someone to discuss the lab results. And then they’re going to say, Oh my god, I have to get this stuff out of me. I knew I had parasites. I knew I had this. I knew I had that. And then they’re ready. But we kind of have to pace people, you know, when we’ve done this thousand plus times between the both of us. So we know that, hey, based on their constitution, how do you pick up on that as a practitioner? Well, it all goes into stress management? What’s in their bucket of stress? Are they going through a divorce? Are they moving cross country? Are they a teacher? Are they working overtime? Are they a CEO? Are they not sleeping? Well? Are they doing too much alcohol? Those things are going to make us say, Hmm, well, you know what, we probably can’t go full strength with this person. Or if we do, we’re going to need to come in and bring in the binders. And the binders are these tools that they can be used in isolation. And we often use those in isolation. However, the majority of time we’re going to be using them as just part of a protocol, meaning maybe during the day, we’re going to be killing bugs. And then maybe at night, we’re going to be using binders or maybe first thing in the morning when they’re fasted and we know fasting increases the excretion of toxins, including mold and mycotoxins. Maybe we have someone do a binder first thing in the morning at six or 7am when they wake up, and they don’t eat until eight or nine when they take their killing or something like that. So there’s a lot of ways to work these into the protocol. And that kind of depends on the person. It depends on the Constitution. It depends on whether it’s a kid or an adult. But these are amazing tools. And we’ll break it down here in a minute.

Dr. Justin Marchegiani: Yep, I like that. I think it makes a lot of sense. So one of the first things we can do to help it die off as decrease inflammation. We know agglutination happens or cells become really sticky when there’s a strong inflammatory environment. So like imagine walking in your kitchen and like the floor is really sticky. It’s like you’re like creeping around that icky feeling on your feet. That’s kind of what happens when you’re inflamed and you start doing detoxification, your body is just all inflamed, things aren’t moving, things are sticky. And we want to keep things loose and flowing and slippery. So the first thing kind of in preparation For all this is getting the inflammation down. So one of the things that I love doing for die off support, we talked about it before. One we’ve already worked on the diet, right inflammations down food allergens, our digestion is better. We’re working on sleep, we’re working on hydration. Getting your hydration up is super important, right? Every time you consume water, you’re diluting the amount of toxins in your body, alright significantly. And so solution to pollution is dilution, high quality, filtered water, reverse osmosis or some kind of really good filter spring water, maybe add some extra minerals in so that you’re getting some minerals to add in some ginger tea. Ginger is natural anti inflammatory, and it’s also a natural anticoagulant. So prevents things from sticking, you could do ginger tea, burdock teas also really good, that’s a good starting place. And then things are moving, your cells aren’t clumping up and sticking together. And then from there, that’s where it’s a good place to maybe add in some binders. So a good first binder would be a really good activated charcoal, especially ones that are kind of more coconut shell based at bedtime, two hours after food and supplements. So it’s kind of in your bloodstream, it’s kind of filtering things out. It’s not getting binding up to all your food and all the nutrients in your food, unless you want to because you’re eating some bad food. That’s a good first starting point to kind of get you moving. 

Evan Brand: Yeah, let’s break down charcoal just a little bit. So people understand what it is they hear it but they’re picturing maybe the charcoal, you know, petroleum based block that your dad used to put lighter fluid on and burn them down and put them in the grill. And then you cook some hot dogs as a kid or something.

Dr. Justin Marchegiani: Yeah, totally. 

Evan Brand: That’s not the charcoal we’re talking about. So basically, what they’re going to do is they’re going to heat these coconut shells, that’s going to be the best. And that basically, they’re decomposed coconut shells. So they’re at a very, very, very high temperature. And then they’re going to combine it with oxygen to, quote, activate the charcoal. And then what happens is, if you were to look at it under a microscope, you’ve got millions and millions and millions of what they would call micro pores on the surface of the charcoal. And it’s when people say bind, it sounds like a magnet, but it’s really not, you know, it’s called an adsorbent agent. And so you’ve got just make sure you had it right. 

Dr. Justin Marchegiani: So it’s not like a sponge. It’s more like a magnet. 

Evan Brand: Yeah, right. So it’s like you’ve got but it’s a weak magnet is my point about the magnet is, is it’s weak, meaning that you actually can create a hurts if you do too much charcoal, for example. So I did it personally, when I went really high dose like 810 capsules, several times a day of charcoal, I actually, I started to get just a little off like I was detoxing too much. And so I found Yes, it is kind of a magnet, but it’s a weak one. Meaning that if you picture like the lava rock, that’s probably the best example in in a big form that people can visualize as those lava rocks. Maybe you had though, that was like old school landscaping. I know as a kid, we had lava rocks in the front of our house. Yep. And so the lava rock, you saw these tiny little holes in it. And that’s kind of the charcoal but but at a bigger level. And so let’s say it’s mycotoxins or heavy metals or pesticide, whatever else is kind of in those little holes. But remember, you still have to move this microscopic lava rock with the, with the toxins on through the intestinal tract. And if you have a leaky gut, some of those things can kind of fall off the law of rock and then go back into the bloodstream, which is why you can hurt even from binders alone. And so this is a really important point I want people to know because more is not always better when it comes to binders. So sometimes you can only handle one cap of charcoal three times a day, some people can handle more than that. 

Dr. Justin Marchegiani: 100% so you kind of highlight a couple things. What’s the mechanism? Well, there’s gonna be an adsorbent mechanism thing absorbed more magnet absorbed more like a sponge, right? absorbent sponge adsorbent more magnet. Again, we want to take it after food and supplements. We don’t bind up nutrition. I like starting in a bedtime. So it’s working overnight because a lot of how we detoxify happens around one to 3am. So I like having it in the intestinal tract when the liver and gallbladder dump. That way, it’s there binding stuff up and we can excrete it better. Now, one of the big side effects of activated charcoal on binders is constipation. So I always tell my patients Make sure your bowel movements are regular before you go into killing and use any binders because if we’re adding things that could slow down the motility more well that’s that’s a problem. Now, it’ll at least help pull toxins in but it’s still going to be slowing down your body’s ability to get toxins out of your intestinal tract. So that’s not good. So if that’s the case, we’re going to be adding in things to help move our intestinal tract and make sure we’re passing all of our bowel movement out in 24 hours or less 18 to 24 hours. So we have that effective mechanism of elimination working. So first thing is first check is like hydration. Second check is making sure your bowel movements are working and then if they’re not, we’re going to be adding things in to make sure our intestinal intestinal tract is moving appropriately before we add in binders. And if we have Side effects of constipation with the binders, we’re going to be adding more support to keep the bowels moving. 

Evan Brand: And it’s honestly pretty easy. I mean, it’s a very common kind of gut reaction, oh my god, charcoal, constipation. But I’ll be honest with you, it’s rare that it’s something that requires special attention. Because a lot of times we’re doing extra vitamin C, because most people are low in that most people are deficient in magnesium. So we’re doing extra of that already. A lot of times the herb formulas that you are using for gut infections, those may have some extra bow moving support in those and just by clearing out infections you and I’ve talked about, in the past how bacterial overgrowth can create certain gases that will slow the transit time down, just by eradicating those infections, the bowels can return to normal. So yes, constipation can happen. But it’s usually not a huge wrench in the gears. And we can overcome it pretty easily with minor tweaks if needed.

Dr. Justin Marchegiani: Yeah, exactly. So it can go either way. Some people when they get inflamed, they’re pulling a whole bunch of water in to flush things out. If you’re more prone to be constipated, you just have to be mindful of it. That’s why when we’re adding in binders, we’re doing it like one capsule at a time. So there’s no big jump, where people get into trouble is they just kind of come in there with a higher dose or they jump too fast. And that’s where the problem comes in. And again, like Evan mentioned us some of the herbs that we give may have a really, you know, good laxative effects are really healthy intestinal migrating motor complex work well, if not, I’ll be using special special things like magnesium and things like that to keep the intestinal tract moving. Ginger is a really good pro kinetics. So we’ll be adding that in and really just helping to support the natural migrating motor complex of the intestinal tract while adding some binders now, once we start adding some binders at nighttime, we may do it sometime midday as well that way we kind of have coverage within a 12 hour timeframe. So we have some coverage at night, some coverage during the day. But I always start at night first, partly because that’s when we were dumping a lot of toxins at night. 

Evan Brand: Yeah, let me just address this concern real quick. And then we’ll move on to my next favorite binder, which is chlorella. So just like oh, charcoal, constipation, people go Oh, charcoal mineral depletion. I’ve talked with a guy named Neil Nathan, who wrote a great book called toxic. I often recommend people buy that to look into binders. He has worked alongside a guy named Dr. Michael gray, who’s a toxicologist, I believe he’s out of Arizona, he’s a guy who’s been working on treating mold. For decades, this guy has been using, I’ve heard insane numbers like 50 to 100 grams of charcoal per day, we’re talking literally 8090 100 capsules of charcoal a day for years. And there’s never been an issue of mineral depletion, ever, ever, ever, ever, ever. So his kind of argument after I probed him on that question was, well, what about mineral depletion? He goes well, so what if you lose one or 2% of minerals? If you’re getting 98% of your nutrition and minerals, still, the the pros outweigh the cons in the sense that you’re removing toxins that are affecting hormones, the brain, the liver, the kidney, so he’s like, yeah, maybe you lose a couple percent. But it’s never been something that’s called like a heart attack. Because you’ve lost so much potassium or anything crazy like that. 

Dr. Justin Marchegiani: Yeah, you’re just going to be taking it away, you’re going to be just taking it away from it. So that’s going to mitigate most of it. If you’re taking activated charcoal with your food all the time. Yeah, maybe you have a problem. But you’re going to be one you’re going to be kept getting a lot of minerals in your water and food throughout the day. And then you’re going to start by taking it at night when you’re not, like overly hydrating anyway, and to at least two hours after you eat and so it’s not that big of a deal. And so yeah, as long as you time it up, right. I just think that’s a moot point for sure. 

Evan Brand: Yeah. All right. So let’s let’s go into chlorella, because I really love chlorella, and I didn’t know too much about it. Besides that you’d see like little chlorella tablets, it always comes in these little green looks like a little Pez or something and they’re kind of hard to chew, but they’re a little awkward to swallow. And then Luckily, I found a couple companies that make micronized liquid chlorella, and that’s what I often use. chlorella is an algae. But it works amazing as a broad spectrum. So a lot of people kind of market it as a heavy metal detox because it has a really unique ability to bind on to heavy metals like mercury and lead and cadmium and arsenic and aluminum things that every modern human has, whether it’s from breathing and car exhaust, to having amalgam fillings in their mouth, but it’s awesome. And I’ve seen I could show you several case studies on pesticides, herbicides, and mold toxins, and chlorella being used to pull those out. We’ve got in fact before and after results of seeing even little kids, 234 year olds that I’ve worked with where they had major, major major pesticides. These were kids that were diagnosed autistic, are on the spectrum. We give them as high doses we can go with chlorella, we retest after three to six months and guess what the pesticides herbicides are gone. And oh my god. I mean, sometimes it just almost makes you cry because it’s like, wow, how is something like this so beneficial, but you’re not hearing about this on the nightly news?

Dr. Justin Marchegiani: Yeah, absolutely. So the first thing we can do to detoxify I always tell patients is stop adding toxins in. So first stop adding toxins in so look at your pesticides right? Look at the food that you’re eating, make sure it’s organic, no GMOs, you know, make note, no added hormones, don’t consume foods and plastics. If you use plastic, you know, try to keep it in the fridge out of the sunlight out of heat out of the microwave. Excellent clean water, filtered water, clean water, if it’s aro, no big deal, add some minerals back in there, I see a lot of people complaining about our water, hey, I rather have my water cleaner, and then add minerals back in and have water that’s more toxic, because you can’t, you can’t add things into the water that make it more or less toxic. It’s either got to be filtered from toxins, and then you can add minerals back in on the flip side. And that’s totally okay. And then from there. And then from there, that’s going to kind of give you that the first foundation because your food’s good, your water is good. And then all your hygiene products make sure deodorants and skincare and soaps were free of toxins there. And that way when we add in binders, there’s going to be just less things that have to be binded. So our body can work on binding up more things that are released from our tissues that are more stored toxins versus toxins that are coming in every day from our environment. 

Evan Brand: That’s a great point. I even forgot to mention that which is duh. Why did people have to get into the situation where they need binders in the first place? Well, it’s they’ve been exposed to toxins. Now, some people they weren’t exposed to toxins on purpose, it was just they ate organic, but then they, you know, stayed a month in a moldy Airbnb or something and they got exposed that way. So it’s not always your fault. But you’re right, you got to empower people and say, hey, look, you can make a choice, you can either eat organic, and not get exposed, or you can eat conventional. But now you’ve got to do the cleanup work. And it’s much better to stop it before it gets in than having to remove it once it’s already in.

Dr. Justin Marchegiani: 100%. Now, outside of that we can do things that help our livers function better, we can work on phase one detoxification support, which will take a lot of these fat soluble toxins and convert them into water soluble. Now these toxins are mobile. So the activated charcoal really works great when toxins are now mobilized, if they’re not mobilized, these binders aren’t going to really work well because everything’s kind of be in the tissue kind of stored up so to speak. So it’s gonna be hard to really grab it. So getting phase one detoxification support dialed in B vitamins, antioxidants, these are going to be key nutrients, maybe liver tona fine herbs like milk thistle, or dandelion or artichoke root. I have a supplement called liver supreme or antioxidant supreme are both my phase one detoxification support that gets things mobilized. Now if they’re mobilized now we can come in there with binders and we can soak it up a little bit. 

Evan Brand: Yeah, phase two is important to now a little involved, I would suppose with the with the binder conversation, because if phase two is not working, you know, phase one can be up regulated. But if phase two is not working, it’s like you’ve got a fire hose going into a garden hose and the backup can happen there. And I’ll tell you personally, and clinically, when I start to use nutrients to fuel phase to like some of the amino acids. I’ve taken it too far like with everything, you know, because I’m a guinea pig. But I’ve noticed massive, massive improvements just by helping out phase two. And then if I ramp up phase two too much, I’ll throw in binders and then the binders will kind of help mitigate the hurdles from up regulating phase two. So it’s a it can be a little bit of a seesaw sometimes. 

Dr. Justin Marchegiani: Exactly. 

Evan Brand: All right, what else what else should we hit on? We should hit on the the Clay’s a little bit as well. You and I love clays that are awesome. You’ve got zeolite you’ve got bentonite clays, those are kind of your top big ones you’ve got like green clays and such clays are awesome. I find that they are really good at heavy metals and molds and will often use it in a blend. So we’ll use a little bit of clay a little bit of charcoal a little bit of chlorella all at once. And they’re well tolerated. I haven’t seen that many people who works from clay so I don’t have any, you know, evidence beyond clinical with this, but I would say that you seem to have less hurting with clays than you do like chlorella or charcoal. I find you can go too much with the others.

Dr. Justin Marchegiani: Exactly, yeah. So just to highlight a couple of things here regarding the sulfur. NAC. glutathione glutathione is a tri peptide anyway. So that’s made from glutamine, glycine, cysteine, right, taurine, MSM, alpha lipoic acid, just getting a lot of our sulfur nutrients on board is going to be huge. That’s going to help provide a lot of the building blocks for phase two. And that way we’re going to be able to, you know, and acetylation, glutathione, conjugation, methylation, right, these are going to involve a lot of our phase two nutrients and so Phase One, like methylation will evolve, like b 12. And full eight, right? So we want to make sure all those things are working if we need Now, some people, we’re not going to be pushing the toxification directly, we’re going to just be, it’s gonna be there more to help pick up the dead debris from things that are being killed in the gut. But if the activated charcoal still not enough, we may have to push more of those phase one and phase two, just to make sure those toxins are releasing, and then the binders will be there to catch things a little bit as well. So a little bit of a push catch, if necessary. If not, we’ll just be doing more of a catch and the push will be more from the killing side. So everyone’s a little bit different. And I tend to a lot of times this isn’t a problem when you have the foundation built in first. 

Evan Brand: Yeah, the funny thing is going into this podcast, I thought, oh, wow, this will be you know, pretty easy to explain. But the more we dive into it, the more this thing gets a little tricky. And so case specific because some people, they don’t tolerate up regulating phase two that much, and other people they have trouble with the binders. So we try to make this stuff as simple as we can. But keep in mind people this is not This podcast is not designed to replace one on one functional medicine care. So if you really want to get to the bottom of these issues, you need help you need us to help guide you through this because I don’t want you to go in and just pop in a bunch of charcoal and you feel bad. You don’t know why. And then you’re confused about what you’re going to do next. 

Dr. Justin Marchegiani: 100% So let’s talk about some binders. So activated charcoal, you mentioned the heating like that the you know the which is going to really have a big binding effect. It’s also going to help with mold as well. We have things like bamboo, bamboo binders are excellent as well. We have things like citrus pectin, which are shown to be very helpful for lead. We have zeolite binders which are very helpful for mold. I think activated charcoal is also very helpful for mold. We have things like beetroot powder, which has some natural binding effects for mold as well. Obviously, we have the medication coolest I mean, which is a really good mole binder. There’s some side effects, though, which can lower your sex hormones fulvic minerals, which have some mold and some binding effects to any comments on the different kinds of binders having chlorella, more on the metal side more for Mercury, though more in the intestinal tract. Anything else?

Evan Brand: Yeah, the colas. darmian is strong stuff. I used it. And, man, I tell you it works. But I do believe that it affected my gut negatively. I do believe that. Now I don’t know if I don’t know if that’s a direct influence, or is it a byproduct of dragging mycotoxins out of the system? I’m not too sure. But I would try to tell people don’t use the prescription binder unless you absolutely have to. And you’re just so miserable. You can’t get yourself out of the rabbit hole with it. Because for me necessary for most. Yeah, for me, I just I really struggled. And I was doing the natural binders for months. And I needed a little extra help. So I did it short term. But I would try to stray most people away the natural binders can be really good if you have enough patience and time to resolve the issues.

Dr. Justin Marchegiani: And you’ve like for you it’s more of a mold thing. So we’re kind of talking for binders for most people is more in the killing side. Right. So for that you had no problems with it. Right? It was more on the mold side, correct? 

Evan Brand: Yeah, yeah, that’s right. 

Dr. Justin Marchegiani: And then you find you fit on the mold binding side, you found that which is better for you when you had what more glutathione and more so for support in along with the binders? Was that true? 

Evan Brand: Yeah, yeah, the glutathione definitely helped as long as I didn’t do too much. And then also helping the glucuronidation pathway that’s also part of this whole conversation. And so calcium D glucose rate did great things for me. 

Dr. Justin Marchegiani: Yes, calcium to glucose. It’s good. And that’s a estrogen binder as well as a mole binder. 

Evan Brand: Yeah, yeah, it really helps with z, what’s called [inaudible], which is something we test for on the urine. So, you know, like we’ve talked about today, you can have a kind of a broad spectrum approach, but we really try to dial it in if we can, if we see specific mycotoxins, we’ll try to give a little more specific. 

Dr. Justin Marchegiani: 100%. So I think that’s really important. Anything else you wanted to highlight on that?

Evan Brand: I think that’s it. I would just say the first step is really trying to get the data, right, because, you know, people hear the word detox and like, yep, I need some of that. And it’s kind of trendy, which is, I guess, good, but also bad because people just jump into detox not knowing why or what they’re doing or what they’re after. So my recommendation as always our philosophies test, don’t guess and figure out what do you have that you’re detoxing? Do you have a heavy metal burden? Let’s find out. Do you have a mycotoxin burden? Do you have pesticides and chemicals? Do you have all that? Okay, great. Now, let’s make a plan to go after these things. So, like I said, Don’t just run to Whole Foods, buy coconut charcoal and take it if you don’t know why you need it. I prefer people have a reason. 

Dr. Justin Marchegiani: 110% I totally agree. So a couple things, right. So number one, people say toxification. Right? Well, number one, you’re always detoxifying. The question is, are you detoxifying at 100%? Are there enough toxins and stressors in the environment that are impairing your detoxification? where certain toxins are accumulating in your body more than are being eliminated. So number one, you’re always detoxify. Number two, it’s more optimizing your detox vacation systems. Also number three people that talk about cellular detox. That’s marketing garbage. Okay. detoxification is happening at a cellular level. It’s called their cytochrome p 450 oxidase pathways that’s happening biochemically at a cellular level. amino acids, vitamins, minerals, nutrients, these pathways are being upregulated all the time that’s happening at a cellular level. So when people talk about cellular detox, that’s just marketing hooey. Anything you do to help detoxification just drinking more water, guess what you’re enhancing, so detoxification just by you, decreasing inflammation. You having really good nutrition in your food, you’re enhancing the certification. Okay, so don’t get don’t get caught up with a lot of these marketing buzzwords. 

Evan Brand: Yeah, unfortunately, detox is probably the most what would you say? Maybe sleazy snake oily type part of functional medicine? 

Dr. Justin Marchegiani: Yeah, it is for sure. I think a lot of the time it is because people come at it from that’s the first step. So they’re taking people and they’re just trying to upregulate these pathways right out of the gates. And people have gut issues, and they’re being nutritionally deficient for a while. And there have a lot of toxins that they’re consuming food wise, or in their life. Yeah, they can really feel crappy and sick. So it’s probably the last thing I do out of the gates again, specifically, right, we’re always detoxifying. So if I see a patient and I don’t hit the toxification, specifically with those nutrients, but I get them drinking better, cleaner water, and get them going organic, and get them pooping every day. I am enhancing their detoxification, like, tenfold just doing that alone. Yeah, yeah. I mean, it’s just funny, I guess, it gets a little-

Evan Brand: Cheesy, because that’s one of the few things that your average person who knows nothing about functional medicine knows about is the word detox. They probably heard it before their friend drinking detox tea or something silly like that. 

Dr. Justin Marchegiani: Right? And then you have like the master cleanse detox, right, which is, hey, that’s cool. You’re giving your digestive system a break, and you’re not necessarily detoxifying. When you when you do that, I mean, you’re not enhancing nutrition, you’re enhancing fasting and autophagy. And, and that can help with stem cells. And that can help detoxify a little bit, because you’re, you’re fasting. So detoxification is a little bit higher there, but you’re not specifically pushing those pathways. Most of those benefits happen because you’re not consuming a whole bunch of food allergens. People feel better doing a Master Cleanse, it’s typically because their diet usually isn’t that great. So when they go on a Master Cleanse, they’re avoiding a lot of those foods that are inflaming them all the time. The more healthy Your food is, when you go to a cleanse, you’re kind of like, Oh, well, it isn’t that big of a deal, because your food’s already really high quality. 

Evan Brand: Yeah, yeah. silica is on the list, too. There are small nutrients. I mean, there’s there’s boron, there’s trace minerals. Or you may be helpful. Yeah, molybdenum can be helpful. So I think we hit on a lot of the big ones, though, a lot of the big tools that you mentioned the pack, then I’ve done packed and I’ll be honest, I haven’t noticed much from it. I do use it in combination with some other binders. But I’ve never done just like a pectin trial by itself and notice any significant difference, meaning I haven’t taken it. And my head’s clear, like with charcoal, if I’m kind of fuzzy, I’ll take a little charcoal and then boom, you know, I’ll notice the clarity. I don’t know if it’s pectins different maybe it’s not binding on to the type of toxin that’s causing the head drunkenness in the first place. 

Dr. Justin Marchegiani: It’s better for lead I think and Merc, okay, yeah, we’re for the heavy metals, but it’s still helpful, you know, ya know, if you’re gonna be detoxifying, it’s not gonna hurt having that in there. It just wouldn’t be the only thing you’d have in there.

Evan Brand: Right, right. Yeah. And so, and maybe heavy metals, they don’t have as much of a quick turnaround time on your symptoms, whereas mold does, like, I know, if I’ve taken a mold hit, it’s like, Whoa, it’s a pretty quick symptom reaction. Whereas, hey, I breathe in a little car exhaust, I’m probably not going to feel anything right away from that.

Dr. Justin Marchegiani: Right. Exactly. Yeah, totally. So anything else you want to add? And I think we really went to town on all this stuff. I mean, I think the key thing I want to highlight for everyone listening, if you’re having a lot of issues or hormone issues of detoxification issues, you know, do the foundation’s out of the gates. But if you’re still struggling, you want to reach out to someone like myself, and Evan, so we can help you all out. We’re available worldwide, and Evan’s at EvanBrand com. I’m at, you can click on our schedule buttons, and we can support you and help you during the process. If you need that extra help. We’ve helped thousands of patients together. So we have a lot of experience. And a lot of people have other issues going on, like gut infections, like hormone imbalances, like inflammation issues like other thyroid or autoimmune issues that are part of the issue. And just supporting detoxification by itself won’t be the fix for that. It’s part of a bigger broader plan. Yeah, on the fence. Feel free to reach out guys. 

Evan Brand: Yeah, good point. And some of our mentors that said you really have to kind of market to people for what they think they need, but give them what they truly need. So a woman may say, Oh, I need detox. Okay, so I’m like, Okay, yeah, we can help with that. But hey, guess what, detox is not your number one priority based on these labs, we really need to do this. And as a side effect of working through this, yep, we’ll detox you as well. So, don’t always assume in your head, you’ve got it all figured out. Because there may be a different set or of priorities or a different order of operations. 

Dr. Justin Marchegiani: Yeah, it’s always interesting when patients come in, and they kind of have an idea what they want. But then the question is, I’m gonna try to give you what you need. And I’ll try to connect the dots. Because if your goal is to get better and address these issues, then we’re totally in alignment, you just may be, you may think this is what you have to do to get there. But as long as you’re open to guidance, then hey, we can adjust that for sure. 

Evan Brand: Yeah, it’s always a fun process. So Justin mention the links I mentioned a moment of time, Dr. J at available online. And me, And that’s it. So we’ll be back next week. take great care. If you have questions, concerns, comments, you know, write us a review and tell us what kind of topics do you do you want us to cover we’re happy to dive into all of it. We live we eat, we breathe this stuff every day, all day. I mean, this is our life. So we’re very passionate and we would love to hear what you want to hear about. 

Dr. Justin Marchegiani: Absolutely. And we’ll put a link down below under references for products that we specifically use and formulate to help support some of the pathways and the objectives that we chatted about in today’s podcast. So if you want to support the show, you can also purchase those products that which we believe in personally use for ourselves, patients and family. Awesome, everyone. You guys have a phenomenal day. It was great chatting with y’all. Take care now. Take care.

Evan Brand: Bye bye.


Audio Podcast:

Gallbladder Attacks| Podcast #228

Gallbladder seems like a small pouch that is located just under our liver and is responsible for storing the extra bile the liver makes. Pretty easy, right? No. The gallbladder plays a very important role especially in digesting fatty foods.

In today’s podcast, Dr. Justin Marchegiani and Evan Brand talk about the importance, and how to take care and address problems when it comes to our gallbladder. Stay tuned!

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

02:52 Gallbladder’s Function

07:43 Risks of Taking Out a Gallbladder

12:45 Mechanisms Behind The Damage

14:58 Hormones

19:26 Gallbladder Damaging Foods

22:32 Parasites

23:53 Hormones and Birth Control Pills

25:50 Keeping It Safe

31:25 Fiber and Sugar

34:15 Tests



Dr. Justin Marchegiani: Hey guys it’s Dr. Justin Marchegiani here, I was out of the office last week. I’m so excited to be back in action. We get Evan brand here in the house and we’re gonna be doing a talk on gallbladder attacks what you can do to treat, prevent and what the physiological cause of this is. Again do we have to rely on conventional medicine to get your gallbladder out. Can we do more natural means to get to the root cause. So, Evan how we doing man?

Evan Brand: Hey man pretty good, yeah. This is timely because as I told you before my mother-in-law she ended up having a bunch of pain last night and goes into the ER and they say after doing an ultrasound, which is one of the diagnostic tools that conventional medicine is really useful for, they said, yep you’ve got gall stones, you got to get your gallbladder taken out and they’re gonna say, hey you got to go right into surgery and get it out and I’m trying not to let that happen but I may lose this battle, it’s hard to say right now.

Dr. Justin Marchegiani: Oh, before we dive in man you had a baby in the last week. Congratulations!

Evan Brand: Good, thank you. I can’t show her off, she’s gone. Mom took her out somewhere, but yeah she’s, she’s healthy. She was 8 pounds 1 ounce. No complications during birth at all. Everything went absolutely amazing and, right yeah, yeah my wife had her in a big old bathtub that we bought and got set up just for that so.

Dr. Justin Marchegiani: Her name is Jenna Rose B.rand

Evan Brand: Yep, that’s it.

Dr. Justin Marchegiani: That’s awesome JRB, I love it man.

Evan Brand: Yeah, yeah.

Dr. Justin Marchegiani: So she’s drunk right there, right.

Evan Brand: There man, mom’s good, mom’s recovering and we’re figuring out our sleep schedule. Still the baby’s sleeping pretty good, she’s breastfeeding pretty good. So far so we can’t complain, I’m still in kind of that like oxytocin overload so I don’t have much to complain about right now.

Dr. Justin Marchegiani: Yeah, a little hazy. It’s always a little tougher when you have another kid because you got to still manage the other kid while this new babies into the world and then maybe it is a jealousy thing going on so you got to manage that so it’s definitely tightrope walking. I’ll be there in like 3 months so it’s like crazy that I’m just, you know, you’re like a sneak preview of what’s to come 3 months ahead of time here.

Evan Brand: I know all I can say is enjoy it with one kid because you don’t realize how easy it is to have one until you have two, and then it’s like wow this is more than twice as complicated as one it doesn’t just double it’s an exponential work scale.

Dr. Justin Marchegiani: I know that’s first six months of the hardest wood getting the sleep on track everything is possible with good sleep. When sleep is not there, everything becomes so much harder across. You got a good sleeper.

Evan Brand: Yep.

Dr. Justin Marchegiani: And of course you’ll do all the right stuff so much of baby sleep has to do with you know early on it’s tough because the baby just doesn’t have the blood sugar stability aspect but having good quality breast milk and good proteins and fats in Hannah’s diet will be huge with providing sustenance for the baby, so, fingers crossed that you guys are on the right track there.

Evan Brand: Yeah, thank you man I appreciate it.

Dr. Justin Marchegiani: Well let’s dive in the gallbladder issue, so physiology 101. What is your gallbladder? So, it sits right below your liver so your livers on your right side, here so in this quadrant here and the gallbladder kind of tucks up underneath and it’s there to primarily concentrate bile salts and bile is designed to help emulsify fat. So think of emulsification is when like greasy pan soap it’s the pan it starts to kind of like suds and break down that’s emulsification in the ability the reason why we want to emulsify it so we can absorb if not if you just try to wash a let’s say a greasy baking dish with just like water use a big sheen right and that essentially what happens in your stool you’ll see that kind of a sheen in your stool and you may even see your stool float if we can’t break down fat adequately, so we need that emulsification so we can break down that fat. And it’s important because there’s actually nutrients in fat like vitamin A, D, E and K these are fat soluble nutrients vitamin A is great for your skin for your thyroid for your immune system D is obviously great for your immune system you make it from the sun as well vitamin E is a powerful antioxidant and great for cardiovascular health and stress and then vitamin K is amazing for your bones it’s also a very important nutrient for your immune ___[04:04], your immune function and healthy vascular system so vitamin A, D, and K really important and you will not be able to optimally break those down within adequate bile salt production so if your gall bladder is not working and that can be a problem. Now, your gallbladder provides a benefit because it concentrates violet and the 15 acts some people report you and higher compared to what your liver could do so your gallbladder sits there. It’s just little pouch and then it concentrates that bile. And then when you eat food by protein and fat primarily it’s gonna be fat but typically protein is batter together that’ll go into your stomach you’re gonna make a whole bunch of stomach acid that lowers the pH. That nice low pH causes activation of proteolytic enzymes. That nice low pH then goes into your small intestine. That nice low pH then triggers bicarbonate from your pancreas which helps bring that acidity back to neutral about,   but that nice low acidity triggers a hormone a hormone peptide called CCK, or cholecystokinin for short, and cholecystokinin causes that gallbladder to contract and release that bile salts and that good acidity also causes the pancreas to produce light pace in proteolytic enzymes lipase means fat digestive enzymes proteolytic, means protein digesting enzymes so we need that nice low pH, and that triggers our gallbladder to work and if we don’t have a good gallbladder, that bile from the most part your liver becomes your gallbladder. So you’ve become and hepatic bile duct expands and that gallbladder just kind of drips and it doesn’t really get to that nice concentrated fashion and work as well, so you’re not gonna have good fat digestive capacities.

Evan Brand: Man, I didn’t even know this there’s so cholecystokinin can also be its officially called pancreozymin,  did you know that?

Dr. Justin Marchegiani: No, I didn’t know that was, uh, another name for it.

Evan Brand: I guess that’s another name for it. But yeah, so it’s made right there in the first sect ion of your small intestine. That’s pretty cool. I never knew that name before. Yeah, this is interesting because you, you gave a really good visual about the whole bacon grease on a pan thing because it’s fat soluble when I picture that and, and I, and I use your visualization. I’m seeing all these nutrients that are almost hidden or protected by the layer of fat and if you can’t bust apart that fat and emulsify it, it’s like those nutrients just go to waste you could be eating those nutrients but if you’re not emulsifying the facts those nutrients are not really getting absorbed and I think this is why so many people you even who take vitamin D supplements, maybe they’re deficient because they’re not maybe one they don’t have a gallbladder or two they’re just not eating it with fat or three they just don’t have the emulsification process working.

Dr. Justin Marchegiani: 100%, and again like if you’re eating really good foods fats and proteins and that’s not digesting properly a lot of times, you’re gonna feel nausea. You’re gonna have indigestion because a lot of these proteins and fats they’re gonna go rancid. They’re gonna rancidification and  then they’re gonna get putrified right so rotting proteins Beautification rotting fats rancidification fermentations the carbs and that can create a lot of bloating and gas and digest the de-stress, so and that can even create more nausea. Yhen what tends to happen is a lot of these kind of people are, are ones that tend to go more vegan, vegetarian plant-based because they’re really just having a hard time with these harder. Let’s say energy intensive foods to break down and then their diet starts to shift so we got to get to the root cause and say what’s going on with our digestive system and figure it out.

Evan Brand: Well, you know, what I just found out too is kind of a risk of getting out the gallbladder is the increase of colorectal cancer goes up quite significantly. When you get the gallbladder removed, if you just Google gallbladder or they call it a cola how do you even pronounce this, is a sola, coalescedectomy-

Dr. Justin Marchegiani: (Cross-talking.) Yep.

Evan Brand: Coalescedectomy, anyway, remove the gallbladder alright it’s quite significant, I’m trying to find the exact percentage here but I would just say that there is a big increase in different types of cancers after you get the gallbladder removed and I would say probably just because the gallbladder does have some function to help with detoxification, because you’ve got this connection between your liver and your gallbladder and your bile so that whole system gets disrupted if gallbladder is removed.

Dr. Justin Marchegiani: Yeah 100 % yep, so in general we have like two major ducts right we have like this common, this common bile duct right, and then we have this pancreatic duct because you have bile coming out so you have liver, gall bladder, common bile duct ,or the common duct and then you have the pancreas hanging over here, and you have a successive pancreatic duct. So what happens is these kind of conjoined and then they eventually go to this hepato pancreatic ampule er there’s a couple names for it, it’s the same thing it’s basically just where the liver and the gallbladder duct meet the pancreas dock and then they go into the small intestine. You can have stones that go right after, they, here they go a little bit lower. You can have some stones join now when those stones are there it can create a blockage and it can create a backup of enzymes in the pancreas, and they can create a backup of gall bladder or the bile or essentially you can create more pressure where those stones are up in the gall bladders and then you can create pancreatitis issues on the pancreas side right because it tees to the right and then we’re at each to the left. You can create inflammation in the gall bladder right and these are both issues so typically they lean more on pulling out the gall bladder than they would the pancreas just because the pancreas has a lot of other exocrine functions like insulin and glucagon and other types of hormones so they typically go right to the gallbladder and remove it. Now we can talk a little bit about should you remove itn should you not. It just depends on how acute it is and how long it’s been going on. But I’ve had great experience saving people’s gall bladders by doing some of the things that we’re going to talk about in a bit so you really have to sit down and talk with your doctor see how your immune system is doing. See how inflamed jar but you really if you’re gonna let’s say try some of the more natural things to save your gall bladder, you really want to be monitoring it especially if you’re on the pancreatitis side because that can definitely be dangerous. Any thoughts on that Evan?

Evan Brand: Yeah, I wonder if looking at the pancreas, if that would be something they would look at via blood or if that would just be the ultrasound maybe they would look to see if the pancreas is inflamed, I mean how would you judge the pancreatitis so you would know?

Dr. Justin Marchegiani: That’s a great question. I’m not sure the exact what they — I imagine the ultrasounds and to be a big component in it they’re probably gonna also look at your immune markers as well to see how jacked up your immune system is from what’s going on and like you probably also look at some various pancreatic enzymes as well.

Evan Brand: Okay here’s the National pancreas Foundation testing would be yes ultrasound so this would look for acute pancreatitis there’s an endoscopy basically endoscopy type of ultrasound that they can do them RCP which is basically like a special type of MRI and then a CT scan.

Dr. Justin Marchegiani: Yeah and they’re gonna look at also the pancreatic enzymes like we talked about the amylase and the light base.

Evan Brand: Okay.

Dr. Justin Marchegiani: Exactly, so yeah when you understand physiology, it’s not that complicated because you only can test them look at, so many things so you have your physical exam where they’re just gonna touch and and poke in that area and see where that pain is and just assess how it feels on the outside. They’re gonna look a little deeper with an ultrasound. They’re gonna look a little deeper with immune testing to see how much your immune system is stimulated and also look at the enzyme see how bad the enzymes are and that’s normal.

Evan Brand: I mean if you had a gallbladder attack, it’s normal to have some back up and for that pancreas to be dysfunctioning a bit. It doesn’t mean, you know, just if you do have maybe some pancreatitis, I don’t think that necessarily makes a situation any more detrimental like if you avoid surgery. I don’t think that means you can’t avoid surgery if your pancreas is inflamed bit.

Dr. Justin Marchegiani: Yeah. My biggest thing, because this is a podcast and we’re not seeing people individually. So make sure you check with your doctor just know that every conventional doctor or surgeon is going to be prone to pulling your gallbladder out because that’s what they do. They don’t understand nutrition or the root cause of what’s happening so you have to understand that to begin with ,but my goal is at least to get your doctor’s blessing you at least try some of these things and then you can come back and monitor and see how you do, but we’ve had great success. So let’s talk about some mechanisms that drive these problems, so the first thing I would say is just poor digestion to begin with, right. We don’t have enough stomach acid, we don’t have enough stomach gas so we missed the stimulation for the pancreas pancreatic output. If we miss the stimulation for the pancreatic out, but we probably have missed stimulation for the gallbladder to contract and the more we have bile that sits in our gob line or longer we can get crystals to form and when these crystals form at some point your gallbladder will start to contract, and that’s like going and petting a porcupine. Like giving a porcupine a big hug right because these crystals are forming and then they’re inside this gallbladder now the gallbladder contracts over time and it’s like given that pork you find a big hug and then you get a lot of inflammation then they go and they’re gonna test your gallbladder via ultrasound then it’s, yeah, it’s inflamed we got to pull it out but it’s not getting to the root cause of why it needs to be pulled out or why it’s inflamed to begin with so we want to. Just keep that in mind.

Evan Brand: Yeah well said well also we’ve had some people that they’ll go from like a really low fat or a nonfat diet – paleo and then they have pain in that area. Kind of that low right side under the ribcage there, and I think your analogy works perfect for that which is that their gallbladder really probably hasn’t been being worked it hasn’t been being squeezed and pumped like it would if they were eating good fat so that’s why some people will go on paleo or keto or something similar and they’ll complain of issues.

Dr. Justin Marchegiani: Yeah, I think a lot of women have been brainwashed. You know, from the 80s or 90s where you’re kind of going lower fat and then when you’ve gone lower fat for a while and that gallbladder is not having to contract. It’s like the equivalent I’m not changing the oil in your car for a while that oil in your oil tank gets sludgy it gets really sludgy it’s not moving well and then it’s possible that you could have a blockage or a stone could form and then you start eating paleo and you’re eating all these really good healthy fats your gallbladder is contracting you’re hugging that porcupine or that that backup occurs maybe to your pancreas, and back to your gallbladder and then you get a whole bunch of inflammation but and then you’re told hey we got to get your gallbladder removed, so we got to understand the mechanisms here another major mechanism is estrogen dominance so if you’re a woman or even guys – because guys are getting exposed to lots of estrogens in the food the water and through plastics and pesticides and glyphosate, that this can cause the bile to get more sludgy. It can turn it into molasses, so you have kind of let’s just say more weakened or decrease bile flow and this can create issues as well so sludgy bile can be a big concern in the hormones have a major impact on that.

Evan Brand: Well now that you say that, the natural question becomes what about all the women that are on bio identical hormones and they’re getting put on progesterone and estrogen creams and all that I mean that’s got to be playing a factor in this.

Dr. Justin Marchegiani: Yeah, I mean if you’re on hormonal support make sure it’s bio-data   and make sure you’re being monitored. Make sure it’s really being monitored so you know that you’re not in an estrogen dominant state. You want to make sure you have a good ratio of estrogen to progesterone, so typically on average is about 22 to 23, to one progesterone over estrogen right because progesterone should be more dominance but a lot of women just natural they’re more estrogen dominant and a lot of people if they’re supplementing hormones a lot of times they may not provide that good progesterone with it or if they’re cycling females, they do it at the wrong time may just do progesterone throughout the month which is not what you do for a cycling woman because they have a follicular phase which is the first half and they have a luteal phase which is the last half first l, and luteal for last and that last half is where progesterone really predominates and I’ve seen a lot of doctors recently where women they’re cycling they’re still in their cycling age their follicles are still active and they just kid progesterone flat line throughout the whole month that’s not how you treat a cycling female.

Evan Brand: (Cross-talking.) Yeah, well-said.

Dr. Justin Marchegiani: So getting back to that we talked about the hormonal imbalance and then of course if we start having sludgy or dodgy bile flow that’s going to start to impair really good fats, and fats are great because they make up our cell membranes they all. We also tend to have fat and cholesterol together a lot of times and cholesterol is a really important hormonal building block so when you start to have poor bile flow and poor fat digestion then you start to have more bloating and gas issues because things are rancid if I and putrifying in our guts right and then we need these important nutrients to make our hormone so then we start to have digestive issues and now we start to have more hormone issues because these building blocks aren’t being absorbed and we know vitamin K vitamin A is really important for the thyroid and then we start having thyroid issues. And we also know vitamin A is really important for skin too and then you start to have skin issues so you can see with some of these cascades you can start off with poor digestion got symptoms hormonal imbalances skin issues and then when you start affecting more hormones, you can affect mood cognitive so you can see how that gallbladder domino can fall and then so many other cascades of symptoms can occur after the fact.

Evan Brand: Yeah, well thyroid too I mean we could go on and on we if we unpack this thing fully this could take us all day, but we know that low thyroid, so hypothyroidism and especially Hashimoto’s. you know that’s gonna be a link to with gallbladder function if your thyroids under functioning that’s gonna affect things to the stomach acid you already hit on that so i always think of H pylori soon as you stay low stomach acid, i think of all these women with H pylori infections or women that are on the anti-acids or PPIs that’s a contributor to.

Dr. Justin Marchegiani: Big-time, so being on PPI is also antibiotics because antibiotics really mess up our gut bacterial balance and then that can really have some negative effects of – some studies showing that antibiotic exposure can significantly increase cholestasis so stasis this means like the flow is impeded so the flow starts to get more dodgy and kind of more like molasses versus water so to speak so that can start to create issues with bile flow and then of course we talked about the stomach acid and enzymes the next big when I say it would be food allergens

Evan Brand: Yeah this is huge. You gave me a good article on this it was about Dr. Jonathan Right, who you and I both love and look up to his book Why Stomach Acid is good for you. Its amazing, if you don’t own that book it’s like bucks on Amazon totally favorite books of all time and he talked a lot, yeah, I mean we’re talking I was telling you I think he’s in his mid to late 80s now I mean he was talking in the 1960s about food allergies in this article food allergies and what and in the contributing factor to took all bladder issues and he was saying that eggs was number one the number one offender for these people   90 almost 93 percent of people that they were studying had an issue with eggs that’s gigantic and then.

Dr. Justin Marchegiani: Also number two is pork aka bacon. So this is big because if you’re in the paleo community and you’re on a paleo template you’re probably eating a lot of eggs and bacon so one of the first things that we see with patients is if we have any gallbladder issues we pull out eggs and bacon and I’ve seen it work phenomenal now after that there’s I’ve done a video on this a few years back so we’ll try to put that the gallbladder video in the references, if you just put my name and gallbladder you’ll probably find the article in the video but we have eggs and bacon number 1 and   2, onions number 3, chicken and turkey 4 and 5 and then milk coffee and then we have some citrus oranges and then corns beans nuts apples tomatoes peas cabbages spices peanuts fish and rye to follow so I gave you a long list and you may be overwhelmed the, the biggest thing I’d focus on is the first yeah focus on eggs. I focus on the baking component. I focus on the coffee and I’d focus on maybe chicken or turkey but at least do those first out of the eggs and bacon maybe some coffee because those are pretty common and see how we do from there now of course the gluten and the refined sugar in the trans fats the junkie or standard American foods are like first so if you got someone that’s on a standard American template well first thing is just try to get them to go paleo first that may be a good first step but go paleo but cut out eggs and bacon as a starting point and maybe coffee just to see how we do to start.

Evan Brand: Yeah I don’t do eggs that often. I mean I had a lot of digestive problems with them in the past when I had parasite infections. I couldn’t tolerate eggs they send me straight to the bathroom so I don’t know if that was related to gall bladder if that was just due to my infections but now I’m ok with eggs I just don’t really care for them I only eat them maybe, maybe once a week I’ll do a few eggs.

Dr. Justin Marchegiani: I mean eggs are a super food there. They got a whole bunch of really good fat soluble nutrients in the yolk really good protein source. I think eggs are phenomenal but not everyone can do it and if you can’t do it just make sure you, if you love it, rotate it, if you love it, rotate it. So, we have those common foods of course we’re going to add in extra enzymes and hydrochloric acid so we can break the foods down right those would be the next steps and I would say a couple of other things here for poor digestion is you kind of already alluded to it with H pylori but other types of infections whether it’s SIBO bacterial overgrowth whether it’s other types of parasites blastocyst is hominis Giardia Giardia is also known to hang out in bile ducts in the out ladder so Giardia can definitely be a gallbladder a stressor for sure I don’t remember if.

Evan Brand: I told you that I mean this was coming up on four or five years ago, now I’m pretty confident I had a gallbladder attack due to Giardia, I mean I was doubled over in pain and it was in that low right quadrant of my abdomen and that was when I got my stool test back that said Giardia is, so if you just type in Giardia bile duct you can read about it they’ve known about this since like the s that Giardia can hang out around that area and cause sort of a phantom gallbladder attack I mean it’s real the pain is real but it’s not actually a gallstone or anything it was the Giardia doing it which is hard to believe because it’s such a tiny organism it make you think how could it do that.

Dr. Justin Marchegiani: Yeah exactly, and also healthy bile flow is really important because bile acids which is what they are vile acids help provide a really good environment for good gut bacteria and keep the bad stuff down in the gut, so when you start having poor bile flow and you’re not producing good bile guess what happens you have less bile acids in the intestines so then you start to have more gut bacterial imbalances so we just have imbalances and the bad bacteria higher amounts of bad verses lower amounts of good and then this starts to wear away or create leaky gut because now we have this dysbiosis. Bad bacteria tends to produce something called lipopolysaccharides or endotoxins that’s the outer coating of the bad bacteria and it can be stressful on the gut lining and actually can create leaky gut so another mechanism is this poor bile flow can, can create imbalances and bad bacteria and that bad bacteria can also start to affect leaky gut now also one other thing we talked about hormones right but also birth control pills are in a similar category especially most of them are going to be estrogen base and they’re gonna be very high levels faster than      to times typically more estrogen than normal and that can start to sludge up gallbladder and bile flow so you can start to see right birth control pills prescribed decrease bile flow decrease bile acids and the intestines more despotic bacteria less good bacteria leaky gut more food allergens food allergens then cause markov ladder is so you can see how that vicious loop kind of plays out ,and then also you can add in while your immune system gets compromised more infections come in that feeds back to more gallbladder stress that you can see the vicious cycles here and you can see how okay just cutting out my gallbladder doesn’t really fix that that mechanism is still in effect.

Evan Brand: Yeah. Well that’s why people report having a lot of pain and post gallbladder issues and they say well I’ve got my gallbladder remove and I’m still having all these symptoms. So some of the sites that we had referenced about symptoms after gallbladder removal could be guess what gallbladder attacks, nausea, vomiting, discomfort, gas and bloating, burping, and belching, heartburn new or worse Barrett’s esophagus, constipation, diarrhea, weight gain that’s all after the gallbladder is gone so it’s really not a miracle cure as it’s promoted unfortunately.

Dr. Justin Marchegiani: Exactly so if we can avoid gall bladder removal, that’s ideal. If it’s incredibly late stage it may be tough but if we can get to it early enough we can definitely keep your gob wider now. So we have the foods, we have the gluten we have the refined sugar, right we have the big things on the Paleo side which are eggs and bacon now when your gallbladder is kind of inflamed we may have to go a little bit lower on the fat in the meantime just because we don’t want to be hugging that porcupine so to speak meaning gallbladder stones contracting on those stones could create more inflammation. we may have to go lower fat or at least rely more on coconut oil for our fat because that does not require as much bile basically bile flow to be able to emulsify coconut oil and then we want to cut out some of those bigger foods we talked about the bacon and the eggs and we’d probably do some leaner proteins good healthy vegetables and lower sugar fruits maybe a little bit of safer starches and keep it all cooked really easy to digest use enzymes use acids and we also want to use supplemental bile salts to break down the small amount of fats that we are eating but we would want to keep the fats down just because you wouldn’t want to be causing that gallbladder to contract around those stones and pet that porcupine so to speak, yeah.

Evan Brand: And if the if the media were trying to sabotage you, they would take that clip that you just said, you may need to go lower – fat and use it against you just to be clear, that is the only time you’re ever going to hear him say go lower fat that’s in this context don’t know the context of-

Dr. Justin Marchegiani: It’s a transitionary period to allow the inflammation to drop to bring and support some extra digestive nutrients so your body can actually handle the fat that you’re taking in and then as the inflammation and the gallbladder symptoms in the pain improves then we can start to taper it up but this advice that I’m giving you really want to be working with a functional medicine doctor you do not want to be doing this on your own absolutely not.

Evan Brand: And I just wanted to point out that because some people may be driving or listening or something and they hear oh I need to be lower fat that’s in the context of this.

Dr. Justin Marchegiani: It’s a season for a reason and it’s designed to help take stress off those systems so they can heal better. Now there’s certain things that will add in as well like we have certain supplements in our line that are have ox bile in it or we’ll use phospholipids like phosphatidylcholine or phosphoric acid which can help dissolve the stones and help decrease the nausea. We may do things like dandelion or fringe tree or artichoke which help thin out bile flow and help support and nourish the gall bladder we may do extra things like beetroot which thin out the bile salt as well we may do things like taurine that help with bile flow, as well so we may do these different things to support and nourish the gall bladder. In the meantime we may do extra stomach acid and enzymes and of course we’re gonna look deeper at the gut and then got bacteria we’re gonna look at some of the lifestyle causes whether it’s medication or hormones that may have driven the issue to begin with and we’re also gonna dive in and look deeper at what the if there’s leaky gut what the potential causes of leaky gut are do you have also some infections that are happening so we got to hit this thing you know 360 degrees it’s really important.

Evan Brand: Yeah, well said. I’m glad you gave all the notes about. Okay, here’s what you do in the situation but then you always have to work backwards because if you just take a digestive enzyme that hasn’t addressed the root cause, yeah, I’m gonna call it and you guys credit the root cause because maybe your age above and you have low stomach acid because you’re aging but you still go to work backwards and fix the other stuff too.

Dr. Justin Marchegiani: Exactly. Now couple of tests that we’re gonna see here or you know first thing is pain that’s gonna be there. Second will be ultrasound to look and see the inflammation in this area and then third, are gonna be the blood markers for the gall bladder you’re gonna see alt or ast for the liver which can be affected by the gallbladder Gigi T’s more specific to the gallbladder and then of course you have, um, you have a LP alkaline phosphatase. They’ll be another one and then you have LDH which are various enzymes in that area of pancreatic enzymes that you can see increase as well and then also the amylase and the lipase are gonna be other ones that may go up if the pancreas is affected. As well so those are the big tests there and then on the functional medicine side we want to dive in deeper to some of the root cause tests which will be gut function just good clinical work up because a lot of people can see low stomach acid can be a really important root cause and then also to make sure we’re infection free cuz infections can be a big part of what’s going on and of course if, like for instance your mother-in-law, I mean if she’s had impairments with, you know, good fat soluble vitamins for the last ten years there’s probably other hormonal systems that have been impaired because of it.

Evan Brand: Oh I guarantee it I’ve got her on enzymes. Luckily she’s been on enzymes and acids for a while but yet you know she’s still sedentary you know.

Dr. Justin Marchegiani: I had a study pulled up right here over sixty thousand women regular exercise reduced gallbladder surgery risk by      % she said in Terry she did have a family history of gall stones her mother had her gallbladder removed so there, there is a somewhat of a you know family history which plays a part of part of the battle and then fiber too, you know, she does quite a bit of dairy so I know that’s one of the big no nos to is staying away from, like, your creams and cheeses and ice creams and yogurts and all that and then fiber. I definitely know she’s not getting enough fiber so I didn’t know this until just now so I’m just reading this that I knew fibers’ good, you always hear well fiber is good. Well, why? Well here’s the mechanism. So fiber reduces the absorption of the deoxycholic acid so this greatly lessens the cholesterol solubility in the bowel and promotes its excretion so that’s the mechanism fiber reduces absorption of deoxycholic acid which lessens cholesterol solubility in the bile promotes its excretion rather than the cholesterol forming a stone it.

Evan Brand: Sounds like, yeah, so it basically helps that cholesterol kind of move its way out of the body that way it’s not hanging around too long and forming crystals and stones that makes sense yes. Okay.

Dr. Justin Marchegiani: That’s cool, so, so fiber is key blood sugar keeping your, keeping your out your, blood sugar stable which she doesn’t eat a bunch of good fat so I’m sure her blood sugar’s all over the place.

Evan Brand: That’s probably where exercise has a play into. It’s like what’s the mechanism why would exercise help your gall bladder. I think it has to do with the insulin resistance and the better you know the more insulin sensitive you are the more you can handle extra carbohydrates and of course extra carbohydrates if your insulin resistant that can start screwing up your hormone so as a woman you know you can create more estrogen dominance and higher levels of testosterone when your insulin resistant. And as a guy, you up regulate an enzyme called the aromatase which can increase estrogen formation and that can also dug up and slow up your bile flow which can promote more crystallization and thus blockages and inflammation so all this makes sense so we’re trying to lay out these various mechanisms so people listening can wrap their heads around it from a root-cause perspective, yeah, I always love to read like well.

Dr. Justin Marchegiani: This study says this, but if you don’t have the mechanism behind it, to me it’s kind of useless so here’s, here’s one more and then we’ll wrap up maintain a normal weight so obesity which she’s definitely overweight I don’t know if I’d obese but definitely overweight obesity increases cholesterol synthesis which leads to more cholesterol secreted in the bile and when you lose weight that will that will reduce your risk as well so I mean really it’s the perfect storm we talked about it it’s the dairy it’s the gluten over age     not enough fiber sedentary eating conventional fats not probably doing enough enzymes and acids until I came into the picture and through supplements at her and she took some of it history of birth control I mean it makes sense why this is such a common issue and why there’s billions of dollars being spent year to remove these i found one estimate here that’s around the guy was Doctor. right it’s article you gave me here where’d it go yeah here we go every year in the U.S. four hundred thirty thousand gallbladders, four hundred thirty thousand gall bladders are removed. Average cost is thirty thousand dollars this gets up to an annual grand total of twelve point nine billion, is in with a be twelve point nine billion dollars. Wow unbelievable, that’s a lot of money is that, I mean there’s got to be a money component is that why is it the combination of the money and that the doctors are not trained on this stuff.

Evan Brand: Yeah, I mean if you don’t understand root cause and all you understand is you know as typically its general surgeons doing these surgeries. If all you understand is how to cut then that’s gonna be your solution and again he may not go away cuz you know you have other areas that can be inflamed besides just the gallbladder.

Dr. Justin Marchegiani: That’s right.

Right, and you mentioned that earlier yeah what a trip.

Evan Brand: Well, I’m ready to wrap it up, if you are you talked about the testing so you know from a functional perspective getting the stool looked at we can measure your fecal fat for one that can be a good indicator just to see hey look we have high static rib not digesting facts you mentioned the infection piece looking at H pylori and parasites and bacterial overgrowth and Candida organic acids testing. We’ll look at other types of bacterial overgrowth that can be throwing things off nutritional markers we’ve got a whole ton of nutritional status markers we can look at via blood and urine and then getting your foundational supplements in order on top of your diet, I mean, that’s really the secret sauce right there yeah I think so.

Dr. Justin Marchegiani: I think we hit it all. So if anyone has any gallbladder issues or digestive issues please feel free and reach out to Evan at or me at and we can get you in and schedule for a consult to look deeper at what is going on because we really want to get to the root cause of what’s happening, I mean, the root cause really is. Where you want to be and you want to have someone that can connect all the dots because it’s not just a hormone issue or a gut issue or a leaky gut issue or an infection issue or a medication issue, it’s a combination of a lot of things. Some people that maybe more than others so you really want to look at everything     d and connect the dots. Yep, if we’re doing, you know, put your comments below we really appreciate your comments. Make sure you’re sharing it to friends and family that could benefit we’re trying to just put so much information for people because a lot of let’s just say other people that are out they maybe aren’t as transparent or reachable right they’re hard to get ahold of or they’re just more blogging and you can’t really connect with them via video like this so this is a great medium take advantage put your comments below and give us a thumbs up as well and a share we really appreciate it and then you can head over to iTunes as well Evan / iTunes Justin / iTunes write us or review we really appreciate it.

Evan Brand: Yep good, good, good, good, for all the plugs. The only other thing I would say is take the two minutes to write us a review because when you do that what it does is I’ll actually pull us up in the iTunes charts so when your average Joe Schmo with gallbladder pain goes in the health and nutrition category on podcast will be at the top of the charts and then they click there and they get to hear this verses who knows what else.

Dr. Justin Marchegiani: Exactly. Well, everyone thank you so much. Hope you guys have a phenomenal week I’ll be back for some live Q&A; so stay tuned subscribe to my channel hit the subscribe they subscribe button hit the bell as well to get notifications. Evan, congrats on the new baby, will talk soon man

Evan Brand: Thanks, take care.

Dr. Justin Marchegiani: Take care, bye.



Improving Gallbladder Function with Functional Medicine | Podcast #216

Digesting fat is so important for one’s hormone growth and for healthy cell membranes as every single cell has a lipid bilayer. If one wants to be a good fat burner on a ketogenic template, it is really important to have great gallbladder function.

In today’s podcast, Evan Brand and Dr. Justin Marchegiani talk about utilizing functional medicine principles and assessment to figure out how one’s gallbladder is doing. Listen as they talk about what can one do about it, the common gallbladder symptoms, root cause solutions, and how can one get better from these symptoms. Stay tuned for more!Evan Brand

Evan Brand

In this episode, we cover:

00:35    What is Gallbladder?

04:47    Consistency of Chewing Foods

08:16    Bile Surgeries

14:18    Autoimmune Issues that Affect Gallbladder

17:28    The 3 F’s of Gallbladder Issues

20:26    Some Advises if Your Gallbladder was Removed

26:32    Comprehensive Stool Test


Dr. Justin Marchegiani: Hey there, it’s Dr. Justin Marchegiani, welcome to today’s podcast. We’re gonna be talking about utilizing functional medicine principles and assessment to figure out how your gallbladder is doing. Also talking about what we can do about it, what are the gut- what are the common gallbladder symptoms, what are root cause solutions, and how we can get you better. We know, digesting fat is so important for your hormone growth, for healthy cell membranes. Every single cell has a lipid bilayer. And also, if you wanna be a good fat burner on a ketogenic template, it’s a really important we have great gallbladder function. So Evan, welcome to today’s podcast, man!

Evan Brand: Hey man, thanks for having me.

Dr. Justin Marchegiani: Awesome. Well, let’s dive in brother. I’m excited to- to dive in. So, first off, let’s just first dive in just to kinda physiology 101: what is the gallbladder? Why is it even so important? So, off the bat, gallbladder is kinda in this upper right quadrant here just beneath the rib cage, ‘kay? If it’s tender in that area like they’ll do a- a palpation that’s called Murphy sign, uhm, in that area where they’ll look for tender type of gallbladder issue where the gallbladder’s inflamed. But the gallbladder, it- it basically concentrates bile at about a 15 times above than the common hepatic bile duct in the liver wood. So when you’re having your gallbladder removed, that common hepatic bile duct up in the liver just drips bile all the time, it’s not specific, it’s not during a fatty meal, just kinda hits, and you can definitely have some bile acid diarrhea issues. When you have a gallbladder it concentrates that bile 15 times and then allows it to come out and time it, it- it squeezes, it contracts, and s- puts up that bile especially during a fatty meal ’cause you have these hormones in your stomach when that food- when that uhm, kind, that mixed up food in your stomach gets released into the small intestine. Uh, the nice acidity of that stimulates this uhm- neuropeptide called cholecystokinin or CCK for short. And that cause the- the gallbladder to contract and stimulate all these bile release which helps with fat digestion. If we don’t have a gallbladder, we’re not gonna be able to breakdown fat optimally through biliary concentration.

Evan Brand: Yup. So, you’re in to that fast, I’m just gonna repeat it so it gets into some people’s heads.

Dr. Justin Marchegiani: Mm-hmm.

Evan Brand: So, you say, when your- you put food down the hatch, especially fat, it enters the digestive tract, the body says “Okay, boom. There’s fat in here now, I’m gonna start making CCK”, and that comes from your duodenal, and I believe the jejunal as well, and then- it- to respond to the CCK, then the gallbladder goes “Oop, CCK is in the neighborhood, now I’m gonna release my stored bile because we’ve got fats to take care of”. So then the bile, or they call gall, will start working on these fats and then turning those fats into usable fuel.

Dr. Justin Marchegiani: Yeah, think of emulsification is like you have a greasy pan, and you put a drop of like soap, right, like some- some dish soap like dawn dish soap, and it kinda breaks it up, it emulsifies it. Think of that’s what’s happening if you got this greasy pan in your stomach, which is all the fat in your stomach going into your small intestine, that emulsifies it and allows your body to break it down and absorb it. It goes in these little things that form uhm- a- uh- a- a- a micelle, and that allow it to get into your body and be able to utilize it. Now, going up one kind of marker is hydrochloric acid levels. This is even important, this is more important because hydrochloric acid stimulates, it lowers the pH, and a nice low pH triggers cholecystokinin. So, we also need good pH function, good hydrochloric acid function and then that then, in the small intestine really gets the bile going, and then we also have some enzymes in the pancreas called lipolytic enzymes, lipase enzymes that also help with the pacre- with the- with the gallbladder in the- in the bile digestive process.

Evan Brand: Well, you make a good point, ’cause when we jump into this conversation, if we’ll look at the whole digestive cascade, as a big row of dominos, when you get to CCK and you get to the gallbladder, you’re really talking 3 or 4 dominos down the list but it’s good that you went upstream first to the mouth, where that’s where you’re chewing your food – hopefully you’re chewing your food, you’re not rushing through your meal. That’s why I don’t like things like chipotle, I enjoy the food itself, but it’s all soft, it’s mushy, meat and rice and guacamole, and you can just shove it down the hatch and you really have to chew the stuff. So, if I eat a soft meal, I still try to be very condescend about chewing, chewing, chewing, chewing, tellin’ the digestive system, “Hey, something’s coming down the hit- down the hatch”, but, you make the point about HCL. It’s why it’s so important when we- uh, talking about gallbladder symptoms which we’re getting to in a minute, to look for, and to treat if you have them, H-Pylori, and other infections ’cause, if H-Pylori is reducing your HCL levels, well, you can’t go straight to the gallbladder. I mean, you- you can, you can take bile salts to help it, but you didn’t fix the root cause, it was H-Pylori.

Dr. Justin Marchegiani: Exactly. So, kinda highlighting, we went from the gallbladder. What’s happening at the gallbladder, upstream to HCL, and that- that also activates other enzymes in the stomach called pepsin, and also gets the pancreas producing lipolytic fat breaking down enzymes, and then proteolytic protein breaking down fat enzyme, it’s- it’s very rare that you just have fat by itself, typically fat, protein and cholesterol tend to come together. And then, up one stream above is the chewing part. We wanna make sure we’re chewing our food at least 32 times, that’s about one chew per tooth, right, you have 32 teeth, so think of 32 chews, 32 teeth. And in general, getting your food’s to like an oatmeal like consistency, like- if you’re having a food that’s kind of more predigested like a chipotle meal, you gotta just make sure you at least chew to that good oatmeal-like consistency, and try to be in a relatively stress-free environment because the parasympathetic nervous system is really important for HCL secretion, thus enzyme secretion, and thus, uhm- bile secretion because we need that nice acidity, we need the enzymes, we need the digestive secretion. And for a sympathetic state, all that blood flow is going out extremities, our arms and our feet to run, fight and flee. So, it’s very important that we have good parasympathetic, so good breathing, gratitude, being in a quiet kind of relaxed setting to start our digestive processes.

Evan Brand: You know, I was trying to find some research on this, I am just gonna guess based on the mechanisms we discussed, that people on acid blocking medications probably have more issues with gallbladder. Would that make sense, ’cause let’s say you don’t have H-Pylori infection but you’re on an acid-blocking drug, isn’t that gonna just down-regulate this whole process we’re talking about?

Dr. Justin Marchegiani: Yeah, we need good acidity to trigger that CCK. So, that totally makes sense, right? And then we need- to be able to break down god fats. What are good fats? Well, we have our mono unsaturated fats are gonna be things like olive oil, avocado oil, and then maybe even some nuts and seeds. We have more saturated fats which are gonna be animal products, right? Grass-fed beef, uhm- any of our like, you know, fish, chicken, beef stuff, you’re gonna have omega-3 fats which are on the polyunsaturated category. Omega-3 is more polyunsaturated, and then you also have your saturated coconut oil which I think is your only plant fat that’s saturated, maybe that and palm I think are the only 2 big saturated ones that are plant-based. So, we have our saturated fats, right? Coconut, plant-based fat- coconut, and animal-based fats. We have our mono-unsaturated which typically are gonna be uh- a lot of the olive oil, potentially avocado oil, we have our polyunsaturated, a lot of times which are fish, and then maybe some of the nuts and seeds kind of fit into that monounsaturated category omega-6 kind of category as well. And then we have our uhm- Vitamins-A, D, E and K, “ADEK”, these our fat-soluble vitamins. So if we don’t have good bile-support, we’re not gonna be able to break fat down by the minute which is really good for our uhm thyroid function, it’s good for our skin, right? Higher dose Vitamin-A is great for skin that’s why they use uhm- Accutane which is- is a Vitamin-A analog to shrink the oil cells on the skin, also great for our eyes. Vitamin-D obviously great for our immune system, we make it too from the sun. Vitamin-E is great for our heart, it’s a natural antioxidizing, great for inflammation. Vitamin-K is really good is found in butter fat. It helps get calcium into our bone, right? Vitamin-K2, consider activated- a- activated X by western price, really important nutrients. So, these fat-soluble vitamins, we really need good gallbladder function to absorb them.

Evan Brand: Yeah, and if you don’t have a gallbladder, we’ll get into that in a minute, you know, I was just looking up, uh- reading the bile, the surgeries that people get. When you get into the gallbladder world, gallbladder surgery is just such a huge, huge money maker and it’s done often times in cases where it didn’t have to be done. And I told you we need to get a lady on whose uh, got a specific website about protocols for people with gallstones to try to help give them relief and to save their gallbladder. But another surgery which is crazy to me is called fundo- fundoplication, and it’s what they do to relieve chronic acid reflux. The surgeon tries to recreate your lower esophageal sphincter, by taking the upper portion of your stomach and wrapping it around the lower part of your esophagus and sewing it into place.

Dr. Justin Marchegiani: Wow.

Evan Brand: That just seems insane to me, they call it anti reflux surgery. How many of those people, just have H-Pylori infections that were put on acid blockers, therefore that LAS, that lower esophageal sphincter wasn’t working properly, or maybe they had a mineral deficient or maybe it was a ___[09:18] issue and structurally, that could get adjusted, but instead, they go get their stomach wrapped around their esophagus and sewing together. That’s insane!

Dr. Justin Marchegiani: It really is, and that’s kinda what conventional medicine does. They can go to some extremes to fix things that in my opinion are much more foundational and much more simple. And most of the time I would say 99% of the time, the surgeries aren’t root cause, right?

Evan Brand: Yeah.

Dr. Justin Marchegiani: So if we look at the conventional side, we have things like a HIDA scan which is like a nuclear image, they swallow s- solution that’s nuclear, and uhm- they kind see kind of biliary function, right? You want typically a 33 to 40 percent kind of dejection fraction that’s normal, on the gallbladder. So, you can look at that with the HIDA scan, you can even look at, an ultrasound, uhm, to give you a window of the inflammation in the gallbladder. It’s not gonna give you how much uh, bile is flowing to the duct but at least give you- okay it- it- is there- is it stagnant, or just stuffed in there, is it inflamed. You can kind of get that sense as well. A lot of times they’ll do some conventional testing, ’cause if your gallbladder is inflamed, and there’s an immune response, you may see white blood cells uh- on the higher side, right? Uhm, you may also see certain liver enzymes, ALT is a common liver enzyme, AST is another enzyme that can be effective in the skeletal muscle, you can see GGT, think of the “G” in gallbladder, GGT is a big gallbladder enzyme. Bilirubin is a byproduct of red blood cell metabolism that comes out in the gallbladder. With high bilirubin, we may have some- some backed up gallbladder bile issues. And then a- also, I think alkaline phosphatase is another big one that we may see on the higher side. So, we’re gonna see bilirubin on the higher side, alkaline phosphatase on the higher side, and then we’re also gonna see potential HIDA scan issues, that can- those are- HIDA scans more like pathological.

Evan Brand: Yep.

Dr. Justin Marchegiani: There are a lot of people that are in between that may be okay on the ultrasound or maybe okay on the HIDA scan and we can use some of this functional test as well. Uhm, but really important we gotta dig to the root, underlying issue on what’s going on there. And again, AST is more skeletal muscle but there’s some crossover with the liver, ALT is more liver. Think of the “L” in ALT as liver and then the alkaline phosphatate is a big gallbladder one, also a big one for zinc. Alanine transferase or ALT, asphotate transferase, and then alkaline phosphatase for ALP.

Evan Brand: Well, the good thing is, a lot of the blood markers you just mentioned are pretty standard. So, even if you’re not working with the functional medicine practitioner like one of us, you may be able to get your doctor to just run these labs, refer back to this podcast and look and see if you have an elevation. Now, the only problem is, the conventional reference range for blood testing is very bad. So, you may be quote, “normal” by your doctored standards but our reference ranges maybe tighter. So if we start to seal your ALT or your AST enzymes go up, it may not be up enough to flagged. So, that’s why it takes a trained eye to look at these numbers and see, and we’ve seen it time and time again, we get somebody on gallbladder supplements their AST and ALT go down. So, it’s amazing to see, we gave this nutrient, “boom” look at the blood changing just based on this nutrients, it’s really cool. Let’s talk about symptoms now, I think we’ve given a good-

Dr. Justin Marchegiani: Yeah, just to highlight one thing, you just wanna get that CBC done at- which is a complete blood count, and then also a CMP – Comprehensive Metabloc Panel profile, and it’s important, you need to work with a good functional doc because you may be okay in a lot of these areas and you still may have issues, so now what, right? So you don’t wanna just rule it out ’cause some of these testing are good, you wanna look at subjective symptoms, connected to the anatomy, connected to how your stools look, right? If we have fatty stools, blond stools, excessive amount of wipes to clean out your- you know, to clean yourself after going number 2 or just, you get skin marks on the toilet seat, we’re probably not breaking down fat. And again, if you have too much MCT oil in the morning, that can also do a tube instead as a laxative effect. So, you gotta look at it the trend in general, clinical symptoms, subjective symptoms, and then lab symptoms to really make a complete picture of what’s going on.

Evan Brand: That’s a good point ’cause my AST and my ALT on my blood looked perfectly fine. But when I had parasite infections, I had that low right side pain under my rib cage where my gallbladder and liver are. Your gallbladder is kinda tucked in with your liver under there, so if you look down at yourself on your right side up where that rib cage, if you’re having pain there, when I had parasites, I had ton of pain there, my blood looked perfectly fine. So I don’t want, like you said, you don’t wanna give a- a false sense of hope just ’cause your blood looks okay. There may be other functional problems that you’ll find by looking at stool testing for example. But let’s hit- let’s hit-

Dr. Justin Marchegiani: Yes.

Evan Brand: -on these symptoms, because you mentioned some but we needed just go through symptoms here and tell people, “okay, what would you be experiencing?”.

Dr. Justin Marchegiani: Mm-hmm.

Evan Brand: So, you mentioned, fatty, greasy stools-

Dr. Justin Marchegiani: Mm-hmm.

Evan Brand: You mentioned it takes a lot of wipes to clean your butt, you mentioned the skid marks in the toilet which if everybody is going on a high-fed diet these days, sure, that may be okay but if you’ve got gallbladder problems to start and then you try to go on to ketogenic diet and you don’t feel well or you don’t lose weight and you’re complaining to your doctor, that may be the part of the problem is gallbladder.

Dr. Justin Marchegiani: 100%. Also, autoimmune issues can affect the gallbladder as well. Gluten’s a big one, it creates those condition called primary biliary- what’s that last?

Evan Brand: I think you call it cholangitis.

Dr. Justin Marchegiani: Yeah, primary biliary cholangitis. I mean, typically just “PBC” for short. But basically you can have some scla- scarring of this uhm- on the- the kind of biliary tubes that go out of the gallbladder, and as well as the- you know, the gut- the liver goes to the gallbladder, the gallbladder kind of comes out together with the pancreas and comes out the sphincter of oddi, or the hepato biliary kind of ampulla, and that- that can kind of scar and it can sclerose, it can kind of have uhm narrowing of the- of that vasculature. Of course, it can back up, and if that backs up, and those enzymes can’t get out you can have pancreatitis as well. But that’s an autoimmune condition where your body is attacking a lot of that tubing that goes up to the gallbladder and maybe even can help with the pancreas, and that can narrow and prevent a lot of that stuff from coming out. So of course, gluten is a big component because that can really activate a lot of au- autoimmunity and you can also have a leaky gut, you can also have a leaky gallbladder which does aggravates more autoimmune attack because things that shouldn’t be out in the bloodstream are out and that exacerbates the immune system going after it.

Evan Brand: Yeah, so let me just read a few sentences on these whole PBC thing ’cause I think this is critical. We know, even just this is just standard you know, medical textbook stuff that says “it’s the most common among women”. And we know that Hashimoto’s is more common in women and men. So it says here, “the cause is not clear but we know it’s more common in people with…” guess what, “…hashimoto’s thyroiditis”.

Dr. Justin Marchegiani: Yes.

Evan Brand: So, it says here, “An autoimmune cause is- is thought possible because more than 95% of people with PBC have certain abnormal antibodies in their blood. These antibodies attack mitochondria. What triggers these attack is unknown…”, of course they say that but it may be exposure to a virus or toxic substance A.K.A. ‘gluten’, maybe dairy, I mean, you and I talk so much auto about- about autoimmunity so I’m glad that your brought this up because, you know, these people may have these symptoms, and they’re not gonna know what’s autoimmune in nature, they may just get the- the knife and say, “Hey, we’ve gotta pull this gallbladder out”. Not necessarily, what if we can shut down this autoimmune attack?

Dr. Justin Marchegiani: 100%. Also, here’s the bigger issue too. Okay, great, the gallbladder is removed, your digestion is now forever altered. I’ve yet to meet a conventional patient of a gallbladder procedure, whether surgeons that “oh, by the way, you’re gonna have to add in HCl, pro- or- lipolytic enzymes and bile salts for the rest of your life”. I’ve never really heard that, at least bile salts seem to be added in. I would say HCl and enzymes too, but I’ve never heard someone do that. Now, your digestion is forever altered, do you think there’s a connection with now you’re not being to breakdown cholesterol optimally ’cause that’s gonna be in the bile, right? The bile is 97% water, then you have some cholesterol, and cholesterol salts as well, and you also have some toxins coming out, that’s why if you have uhm- poor, you know, gallbladder-emptying, then you’re not getting rid of potential toxins that are in there too. So, we gotta be emptying that gallbladder. If we’re not breaking down Vitamin A, D, E, and K, if we’re not breaking down our fat-soluble vitamins, which I just mentioned, if we’re not breaking down cholesterol which is the building block for all of our hormones, do you think we’re gonna have problems ladies, uh- as you get into your 40’s and 50’s, with menopausal issues, perimenopausal issues, PMS, and we know the main connection, it’s kind of a slang but, I’ve heard many uhm- let’s just say general surgeons say it, it’s the 3 ‘F’s’ of gallbladder issues: fat, female and forty. And that’s the time to- late 40’s, early 50’s where hormonal transitions happen, and if you can’t breakdown those nutrients, you are setup for a menopause uh- of “hell”, so to speak.

Evan Brand: Yeah, in terms of side-effects, possible side effects of gallbladder remover- removal, it could be anything from pancreatitis, to increased risk of choline cancer to increased digestive sy- symptoms like heartburn, could be constipation. So, we’ve seen people that- they don’t feel well, after they get the gallbladder removed. And uh, like you said, there’s no surgeon out there saying, “Hey, I’m gonna put you on this comprehensive digestive support protocol, after we remove it”, no, they’re gonna you out with anesthesia, cut that bad boy out, and send you home in a day or 2. Uh, there’s a- a whole lists symptoms here I’m looking at now, symptoms of- uh- symptoms after gallbladder removal. I’ve had women have gallbladder attacks, but they don’t have a gallbladder. You know, it’s like, “well, how the heck does that happen?”. So, you know, the- the- the removal is not the “cure all”. Anything from nausea to gas and bloating, distension, burping, belching, feelings of fullness, heartburn, barrett esophagus, diarrhea, dumping syndrome, weight gain. There’s a whole article here all about post gallbladder removal weight gain happening.

Dr. Justin Marchegiani: And part of the reason why women get targeted so much – I hate to say it – is the estrogen. The estrogen kind of makes things sluggish and slow, it kinda takes- it kinda makes it turn into molasses. So, things really are very sluggish, very viscous, and of course, that can affect gallbladder and bile flow. Women that are on, you know, uh, birth control pills, that’s gonna- in- obviously increase estrogen levels, obviously just being stressed, right? You’re gonna take your progesterone, you’re gonna shoot it downstream to cortisol, and that’s gonna basically cause estrogen dominance there because you’re already starting to lower progesterone in relationship to estrogen. You’re getting estrogen in the environment from the conventional meat products, uh, water, plastics, chemicals, hormones in the meats as well, and then you’re also gonna be just getting it, just from uhm- being a woman, having 10 times more estrogen than a man. So, you’re- you’re already predisposed, and then when you add stress to it, it’s going to exacerbate it uh, big times. So, you really wanna make sure that you’re fixing the- like if you’re having- if you know you have a gallbladder issue, you also need to be going after the- the hormonal issues as well. And then we can dive deeper into the food allergies stuff too, so you gotta go after the hormones, gotta make sure you fixed the estrogen dominance, you gotta make sure you fix the digestive aspects, and then we can go into foods later.

Evan Brand: Well, I’m sure there’s gonna be a ton of people that are just yelling at us right now through they’re podcast app or YouTube or wherever they’re listening to us, and they’re saying, “Well, this is not fair, I already have my gallbladder removed, so what the heck do I do now?”. So, do you wanna address that now or should we talk about that later?

Dr. Justin Marchegiani: Yeah, so, off the bat, the underlying mechanism that was driving that inflammation in the body’s still there. Just the end target, the end uh manifestation of it is removed, but now other tissues may start to, uh, have issues, then also if you don’t fix the underlying uhm, digestive im- impediment which is, your fat-soluble vitamins, your cholesterol, your hormone building blocks are now gonna be thwarted in their digestive processes. So, you have to fix that to prevent compounding hormonal issues, 10, 20, 30 years later, number 1. Uhm, and then so obviously this- so- err- if you’re- if you still have your gallbladder, we wanna keep it by doing a lot of the preventative things. But on the food side, I outlined this in a couple of my gallbladder videos are down in the past. But there’s some common foods that are even uhm- let’s just say paleo-approved, but should probably be looked at- look at removing. So, of course we have the refined sugar in the guts. That’s kind of a no-brainer right here. But, uhm, in order of kind of like uhm, the most likely offender are gonna be eggs.

Evan Brand: Yes.

Dr. Justin Marchegiani: So definitely autoimmune template, cut out the eggs, pork, onions, chicken turkey, milk, coffee, corns, beans, nuts, apples, tomatoes, peas, cabbage, spices, peanuts, fish, rye. I’m gonna link my article that goes into this. So, everyone’s probably like, “Say it again!”, no, I’ll put the link below, don’t worry, take a look at the article, alright? But, I have them in most likely to offend to least. So, if you’re overwhelmed after hearing that like, “What the hell am I gonna eat?”. Just start with the biggest 3 or 5, or look at that list and say, “What are the biggest 3 or 5 that I eat on a daily or weekly basis” and just pull that out. Once we get the inflammation under control, we support HCl, we support enzymes, we support bile salt production, we look at the gut ’cause sometimes there can be infections like H-Pylori and giardia, and of course SIBO in and around that ___[22:31] that can exacerbate everything too. So, we get the infections clear, if we get the acidity and the enzymes dialed in, if we cut out some of the common offending foods, we may be able to start adding some of these foods in overtime. But I find pork’s a big one, eggs are a big one, those are like my- my 2 biggest right there off the bat, and they’re kind of paleo-friendly too.

Evan Brand: Yeah, eggs are huge and people over-eat them and, if you have gallbladder issues, uh- when I interviewed Ann Louise Gittleman, she said the same thing, she said eggs are the biggest offender. I’m like, “Wow, I thought that was just me”, no, it’s- it’s a real thing, and then also onion. I think she said onion are ready-

Dr. Justin Marchegiani: Yes.

Evan Brand: But that was- that was a problem for me when I  had parasites and I would try to do like stir or fry and throw some onion in there, I’d end up with that lower right side stomach pain, I’m like, “What the heck is it”, or if it was I had parasite infections but, the other- the other part of it was the onion. So, yeah, I at least temporarily, like you said going on an autoimmune protocol while you’re working with your practitioner to fix the other underlying causes, you’re gonna be in good shape if you do that.

Dr. Justin Marchegiani: Onions are also a ___[23:28] too. So there could be some underlying SIBO or small intestinal bacterial overgrowth going on as well. So, you gotta look deeper at everything. So, kinda like piggy-backing everything, alright? Women are gonna be the- more bigger offenders ’cause of the hormones, because of the- you know, the pregnancy prevention with the birth-control pill, so you have that, right? So we gotta fix the hormones, fix the hormones, number 2, cut out the foods, at least paleo to autoimmune paleo with those additional 3 to 5 to 8 foods I just mentioned. Get enzymes dialed in, get acids dialed in, and definitely bile salts added in, and if you already had your gallbladder removed, definitely do all 3, and those that up and watch your stools and make sure your stools go floating to sinking, right? Oil and water mix, so if you had the stool, with the whole bunch of undigested fat, and oil and water mix, the stools stay on top of the water, they don’t sink. So, you wanna see the stools sink, and ideally you wanna be able to clean yourself, you know, 3 to 5 wipes on average, and you wanna make sure when you flush, you’re not seeing big skid marks all the time. If you’re doing some MCT oil in your coffee there may be some issues there, too much of that can cause some undigested MCT, so be mindful of that. So, foods, acid, enzyme, bile salts, get the infections cleared, and if you’re a woman, get the estrogen dominance fixed, get the hormones balanced.

Evan Brand: Yup, and, how can you do that from a testing perspective, we mentioned the blood, but I’ll just throw a few other components of this in. Number 1 is the stool test, so we’re always gonna be running a PCR stool panel, or gonna be looking for all this. As you mentioned, we’re gonna look at H-Pylori, we’re gonna look for giardia, we’re gonna look for cryptosporidium, blastocystis hominis, there’s a ton of different bugs, there’s worms, there’s parasites, there’s bacterial overgrowth we look at, there’s candida that we look at, that’s all done with the combination of  stool and urine testing. And on the stool, there’s a couple markers that we can track, obviously, you looking in the toilet is gonna be the best way to track. Well, we like numbers, you know, Justin and I like data. So, when we look at steatocrit, which is a fecal fat marker that usually is expressed as a percentage. I like to see it, you know, 10% or below, we’ll see some clients, they’re 30, 35, 40 percent steatocrit, that means they’re not digesting their fats at all, and they while I’m doing a ketogenic diet and I feel like crap, it’s ’cause they’re not digesting anything.

Dr. Justin Marchegiani: That’s it.

Evan Brand: So, we gotta get that steatocrit down, and how you do that, well, one, clear the bugs too, supplement, and then, what was the other part of my brain? The blood, we talked about the blood, we talked about the stool, oh, the beta glucuronidase. So, beta glucuronidase at enzyme on the stool test we look at, that enzyme gets messed up due to bacterial overgrowth. When we see the enzyme is high, that’s when the estrogen dominance probably becomes more problem- problematic because now, they’re re-circulating the hormones. So, we do some like a calcium d-glucarate or a DIM, or something else, maybe a broccoli seed extract to try to get, or could be probiotics, could just be clearing bugs, taking care of the SIBO, the glucuronidase goes back down, and now all these quote, “estrogen-dominance symptoms” just disappear, and it’s really fun to see that.

Dr. Justin Marchegiani: 100%. So, kinda highlighting the test again, look at your symptoms, if you have pain in the upper right quadrant, under the rib cage, if you have problems breaking down fat, if you’re seeing a lot of your fat, your stool sinking or floating on top, not sinking. If we run a ho- comprehensive stool test and we see a lot of uhm, steatocrit, undigested stool, we see that greater than 10 or 15, whatever that lab marker is right in that area, we got problems, and then we gotta dig in deeper, and this could be the reason why you have hormonal issues too so we have to highlight that. Is there anything else in this topic Evan that you wanna go into that we haven’t gone in deep enough?

Evan Brand: I don’t think so, I would just tell people that if you feel discouraged, or, you know, you’re facing surgical removal of your gallbladder, I’m not saying the gallbladder can always be saved. I have a friend of mine, she’s in her late 50’s, maybe early 60’s at this point, and she was having major, major gallbladder pain, and I told her about taking digestive enzymes, but the pain just continue to grow. So, you know, I said hey, you might have to, you know, go to a doctor and get this checked out. This is very recent, so she did. And her gallbladder function was basically nothing, and she went in and she had to get surgical removal and because of with so much inflamed tissue around her gallbladder they couldn’t do the- the- the uh, laparoscopy, where they just give you a small- a small uh surgical side, they had to really cut her open like 6 to 8 inches, they hadn’t take out the gallbladder, and the surgeon told her, that her gallbladder was so heavy, full of stones that it felt like a concrete block. He said there was no way you were gonna save this gallbladder. So, I think there is a point of no return, where surgical removal does happen, we’re not shaming anybody or making fun of anybody if you got your gallbladder removed, that sucks, like she had to get it out, there was no turning back. And now, you know, she’s got tubes coming out of her stomach to drain her bile until she recovers from the surgery. So, obviously, that’s an extreme case but man, uh, you know, it can- it can get to a point where surgery is the only option but we’re just trying to help you before you get to that point.

Dr. Justin Marchegiani: Yeah, so if we don’t have enough, if you don’t eat good fats, then we don’t have good gallbladder flow, then, what happens is, it’s like not changing the oil. A lot of that bile uhm, and that cholesterol can crystalize. And then overtime those crystals can- can produce more and more crystals. And then imagine these little crystals that are like- a little mini or- miniature-like porcupines. And imagine that gallbladder contracting, it’s like giving a- a big porcupine a nice hug, right? Probably not the best thing. So, that can create a lot of inflammation, and the more little porcupine you’re having your gallbladder, the bigger issue every time you have fat that contracts. And then also, we can have potential pancreatitis because of it ’cause those gallstones can eventually produce, can block the bile flow, and that can stop pancreatic enzymes from flowing into the small intestines. So, that can create more inflammation. So, the more this thing, err- there’s more of this issue, the underlying cause goes unaddressed, the more the inflammation accumulates, accumulates, accumulates, accumulates, there may be a drastic solution of cutting out the gallbladder. Now, I would say, the vast majority of the time, it can be saved. We have to make the food changes, uhm, we also do a lot of gallbladder bile support, we’ll also use things like phosphatidylcholine, we’ll do beet root powder, we’ll do taurine, we’ll do dandelion, we’ll do artichoke, French trees, or herbs that’re designed to help to help one thin out bile flow, they can smooth out the little crystals, so imagine like kinda coming in there and smoothing out all the little porcupine barbs. Uh, that way they aren’t as sharp, and then we can be very careful with our fat consumption, maybe we do the tiniest amount possible. A lot of the coconut fats are easier to process and digest. So, maybe we’ll do more coconut fat, we’ll just do- just the- the largest amount of fat we can handle without issues, we up the enzymes, we up the bile salts, and then we give a lot of those herbs to smooth out the bile flow, thin out the bile, and smooth down the crystals. We’ll even do some- some like extra phosphorus drops to even thin out the bile uhm stones as well.

Evan Brand: Yeah, I do beet powder every day. You know, part of that for my circulation issues dues to all the mold in my body, so- so the beet powder’s been really helping. But, you know, back to my friend, you know, she was, she’s a woman, she’s over age 40, she does have excess weight, you know, she is overweight, she is very sedentary, uh, she did have some familiar health issues as well, you know, any- any family history of uhm- diabetes, other type issues like that can- can increase the risk of gallstones which then increase the risk of these problems, so, if you were to take all of the things you don’t wanna be sedentary, you know, overweight, uh, etc., poor diet, she had all those things against her. So, I’m not gonna- I’m not saying that everyone’s gonna end up like that with her case which is extreme but, you know, I just wanted to point out, hey, sometimes there may need to be a surgical removal. But, we just- we wanna try to prevent that. Statistics I found say there is about uh- 3 quarters of a million surgeries every year for gallbladders.

Dr. Justin Marchegiani: Exactly. Then we kinda talked about, our women- right- our- our fat, 40 and female. The big issue is, estrogen is a big uhm cause of kind of making the- the gall uhm, making the bile more sludgy, so is insulin. So, insulin is also another stimulating factor, this is part about I think where the fat comes in there, because the more weight you have typically is more insulin-resistance, insulin’s that hormone that sticks sugar into the cell, converts it to fat, so if you have more insulin, that’s a greater likelihood of making the bile flow more sludgy. So, if you have high levels of insulin, that’s gonna slow up the bile flow, and then if we have uhm, high levels of estrogen or just estrogen dominance, that’s gonna sludge up the bile flow as well.

Evan Brand: Yup. I’m sure we could keep going on this topic all day but, we should probably wrap it up. Reach out if you do need help, you can go to, and Justin’s summit is coming up very-very darn soon. So, I don’t know when you’re listening to this, if you listen to it in the future, and you already missed out, well, you can purchase his summit, but if you’re listening to it ahead of time, his summit is going live very soon, in two weeks at the first week of March. So, go to Go register for Justin’s event, it’s gonna be awesome, I interviewed him, which I thought was probably one of the best interviews possible, and interviewed me, and I talked about some other stuff that he hadn’t talked about. So make sure-

Dr. Justin Marchegiani: [Crosstalk] …interviews too.

Evan Brand: Thank you, thank you [crosstalk].

Dr. Justin Marchegiani: …for sure.

Evan Brand: So, so go register, uh, it’s- it’s gonna be probably one of the biggest events of the year called Thyroid Reset Summit. So,, go check it out and to run through health talks which is like the apple of summits, they do a great job of putting things on, and there’s, I don’t know what, 30 other experts on there. So-

Dr. Justin Marchegiani: 30 great experts. And also, I’m giving way the first uh- 3 to 4 chapters of my new book coming out, the thyroid reset. That book will be coming out in the next uh, few months here, so, get your free intro copy and then I really appreciate you guys picking up the book as well. Get me up there on the Amazon ranking so we can help more people, I appreciate it. And also, just to finish with this uh, article, here, the uhm conclusion, very important here for gallbladder issues, just to tight home, repeat yourselves a lot because repetitions some other skill, here’s the conclusion, insulin resistance is a risk factor for the incidence of gallbladder sludge and stones during pregnancy and after. And then it says insulin resistance may represent a causal link between obesity, overweight and gallstones. So our big mechanisms here, just kind of- f- coming in full summaries, if you missed the whole entire podcast, if you get this one thing, you got it. High levels of insulin, increased gallbladder sludge. High levels of estrogen, or estrogen-dominance, increased gallbladder sludge. Inflammatory foods, right, that drive insulin and inflammatory foods that are paleo friendly like, pork, like onions, like eggs, like coffee, maybe an issue, and then of course the low HCl levels, uhm, the low-fat diet, uh, all of those things and eating in the stressed out environment, those are gonna be your big 3 or 4, then also infections, giardia, gluten-sensitivity, SIBO, all of those things are gonna drive, probably the big 5 factors. Infections, insulin, estrogen dominance, low HCl enzymes, and then hidden food allergens. Those are your big 5 factors of this gallbladder issue here.

Evan Brand: Yeah, well said. And I love my friend to death but my wife and I were driving in the parking lot the other day, and she’s- and- and then we see our friend who just got her gallbladder taken out, and she’s sitting in the Taco Bell Drive Thru, and I’m just like, “No, that’s exactly what got you in this problem in the first place”. So, the diet is so critical, you can’t skip it.

Dr. Justin Marchegiani: Hundred percent, excellent. And for anyone enjoying this, I’m gonna do another live Q&A here tonight, this at- you know, the very end of the day, probably around 5, 6 o’clock here central time. Make sure you subscribe to the YouTube channel, we do a lot of live Q&A. So, go to If you’re listening to the channel now, make sure you hit that bell, that gives you the notification. So, if you’re on your phone, it’ll pop-up as it ___[35:35] doing a live chat. Even if you’re not around for it, just your little- little question in. So, we do a live Q&A, it’s op-in question, if there’s a topic, keep your question to that topic, if it’s a podcast, we may or may not get to questions ’cause we kinda get in our flow state and uhm, we may just be really focused on our conversation.

Evan Brand: Take care.

Dr. Justin Marchegiani: Hey Evan, you have a good one, take care.

Evan Brand: You too, bye.

Dr. Justin Marchegiani: Bye everyone.




Is Your Gallbladder Preventing You from Digesting Fat?

By Dr. Justin Marchegiani

A common theme that we see in any patient that is chronically-ill is gallbladder issues and problems digesting fats. There’s always a hormonal fatigue, maybe a thyroid or female hormone component. And there’s also a digestive component, whether it’s maldigestion, inflammation, leaky gut, or an autoimmune condition that’s emanating partly from the underlying gut issue. So let’s journey through the digestive system, starting with the moment you take a bite of food, and explore why your gallbladder may be preventing you from digesting fat.

Digestion Process

Step One: Chewing Your Food

When you take a bite of food, chewing is really important because it increases the surface area of the food and breaks it down. The more you chew, the better exposure you have to bile salts, enzymes, and hydrochloric acid. And these begin that break-down process. It’s best to take smaller bite-sized pieces of food and chew once for each tooth you have, that’s 32 chews at a minimum—work at getting that food to a steel-cut oatmeal-like consistency.  That’s step one.

Step Two: Breaking Down Food in Your Stomach

When you swallow, the food goes down the esophagus and empties into the stomach. The stomach needs a nice, low pH for proper digestion. Our bodies are slightly alkaline on average, about 7.35 or so, and hydrochloric acid (HCl) is the guy to help get the job done. HCl is very acidic, and it drops the pH in our stomach and gets it into that nice acidic range we need for proper digestion.

When the pH is nice and low, it starts to increase enzyme activity. One of the main ones it increases is pepsin, which is a proteolytic enzyme. Proteo- means protein, and -lytic means to break or cut. So the food breaks down further in the stomach, becoming chyme, which is a mixture of the food, enzymes, and acid.

The Role of The Nervous System in the Stomach

Acetylcholine is a really important compound because it’s part of the vagus-nerve stimulation.  So the vagus nerve is actually cranial nerve number 10, right in the back of the skull. And it goes throughout the entire body and has an effect on the parasympathetic nervous system. The parasympathetic nervous system tells the body to hit the brakes and rest and digest as opposed to the sympathetic nervous system, the fight or flight system. This tells the body to go, go, go.

Our parasympathetic nerve fibers from the brain actually start innervating the stomach. We have acetylcholine being produced in the stomach because of this vagus-nerve stimulation from the brain. So chewing your food and not eating on the go is very helpful because it creates a relaxed, stress-free environment for food digestion. That stress-free environment turns on the parasympathetic nervous system. This in turn stimulates the activity of the vagus nerve and production of acetycholine in the stomach.  It helps get the whole ball rolling from a nervous system standpoint.  This is called our cephalic phase of digestion.

Click here to schedule a FREE Consult with a functional medicine doctor to help with gallbladder issues.

Step Three: Breaking Down Fats and Proteins in the Intestines

The chyme enters the small intestine and starts to trigger some enzymes, such as cholecystokinin and secretin, which break down our fats and proteins.

Cholecystokinin (CCK) is stimulated by increased fat, and it causes the gallbladder to contract and produce and release bile salts. The gallbladder is a small organ that sits just below our liver, and it takes bile from the liver. It concentrates bile (making it more potent), and releases it into the small intestine. Bile’s primary purpose is to break down fat; it emulsifies it, like soap on a greasy pan. It’s also a detox mechanism for cholesterol and hemoglobin or bilirubin, which is like the broken-down skeleton remains of red blood cells.Our bile will deplete itself every six hours or so. So one of the big things we can do is eat good fat.

It’s like changing the oil in our car. If we don’t change our oil for a long period of time, things start to get very gelatinous and sticky and sludgy. If we eat enough fat, it’s like giving ourselves an oil change every day because it stimulates our CCK, which allows our gallbladder to contract and then release bile, and it keeps us from getting gallstones (watch the video above for more detail about gallstones and how these form).

Secretin is a compound made from about 22 amino acids. The lower our pH is, the more secretin we get. And this secretin stimulates our pancreas to make and release more enzymes and bicarbonate to break down our proteins. Bicarbonate is important because our super acidic food coming down from our stomach has to be made more alkaline to complete digestion. Bicarbonate acts like baking soda, regulating the pH, bringing it back up to neutral or slightly alkaline.

Symptoms of Gallbladder Trouble

When something isn’t quite right in the steps of digestion, your gallbladder may experience trouble. There are some common symptoms you can watch for, including the following:

  • Right-sided abdominal pain with possibly some right shoulder pain as well
  • Indigestion
  • Bloating and gas
  • Blonde-colored stools
  • Floating stools (extra fat in the stool is like oil and water, and the fat will float to the top instead of sinking, so floating stools aren’t good)

Causes of Gallbladder Trouble


These are a big common cause of gallbladder trouble. Let’s say you’re already Paleo, you’re already gluten-free—all of these things are already addressed. There are still some other allergens that can cause gallbladder trouble.

In order of the most likely offender to the least, these include the following: eggs, pork, onions, chicken, turkey, milk, coffee, oranges, corn, beans, nuts, apples, tomatoes, peas, cabbage, spices, peanuts, fish, and rye. This may seem like a lot, but start with the most likely offenders and work your way down when trying to pinpoint the food allergen affecting you.


Additionally, some medications, whether its birth control pills, antibiotics, and even some other statin and lipid medications, are known to cause gallbladder issues. Almost 20% of all gallbladder issues are induced by medications.


There are also infections that can drive gallbladder issues. A big one is Giardia, a parasitic infection. Giardia can nest itself up in the gallbladder and create inflammation.

For professional advice on gallbladder issues from a functional medicine doctor, click here!

How to Treat Gallbladder Pain

Now in conventional medicine, doctors see the increased bilirubin levels, they see the inflamed gallbladder then they just want to go in and cut that gallbladder out—that’s it. In functional medicine, we want to address the issue causing the gallbladder pain and trouble.

The easiest things, right off the bat, are to make the diet changes, add in some stomach acid. We add in some bile salts and some bile-supporting agents, whether it’s fringe tree, dandelion root, taurine. These can all be helpful for enhancing gallbladder bile flow, increasing the HCl, and cutting out the bad foods.

Get yourself tested to determine the root cause. Do you have an underlying infection? If so, it needs to be treated. Are you taking medications that may be irritating the gallbladder? If so, we need to find a good alternative. Do you have more symptoms outside of the digestive problems? If you have those gallbladder symptoms—the right-sided pain, indigestion, floating stools, nauseous after meals—there’s a really good chance that you have a gallbladder problem and you need to dig in and get to its source.


If your gallbladder is painful and inflamed, it is likely preventing you from properly digesting fat. While conventional medicine is quick to go in and just cut it out, there are other ways to treat gallbladder trouble and get to the true source of the issue, including changes in diet, eliminating offending medications, and killing off irritating infections. Taking care of the source of the problem may regulate your gallbladder and get it back under control.


The entire contents of this website are based upon the opinions of Dr. Justin Marchegiani unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Justin and his community. Dr. Justin encourages you to make your own health care decisions based upon your research and in partnership with a qualified healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Dr. Marchegiani’s products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using any products.