Natural Ways To Increase Your Glutathione Levels | Podcast #292

Glutathione is an antioxidant that is capable of preventing damage to cellular components and also gives a lot of benefits to our body. For today’s podcast, the topic that came to mind is glutathione. Dr. J and Evan point a lot of information and tips on how glutathione is important in our health, how we increase our glutathione levels the natural way, the pros and cons, and a lot more. Read and listen below. Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

00:37    Glutathione as Tri Peptide

06:06    Conditions Associated with Low Glutathione

11:32    Glutathione in Helping with Treating Cancer

23:03    Food and Supplements

38:46    Tips, Ideas for Higher Glutathione Levels

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Dr. Justin Marchegiani: Hey guys, it’s Dr. Justin Marchegiani here. Really excited to chat with y’all today. We got Evan brand here in the house, Evan, what’s cooking my friend?

Evan Brand: Oh, not much. We cook some bacon and some pastured sausage earlier, but nothing is cooking at the moment beyond that.

Dr. Justin Marchegiani: Awesome, brother. Well, I know we were chatting about topics that for today’s podcasts in the pre show and glutathione was one of these topics that kind of came to mind based on challenges that we’re seeing with our patients based on things that we’re seeing in our comments section on our pages, and we decided glutathione will be a great topic for the show today. So really excited. Let’s just start off the day what is glutathione? So glutathione is a tri peptide. What does that mean? Tri means three, Peptide means essentially amino acid. And there’s three amino acids that make up glutathione. Glutamine, cysteine and glycine, those are the big three glutamine cysteine glycine. Now we really important because these are all amino acids. Sulfur rich amino acids and you’re not going to find a lot of these amino acids by the way in in plant based products, you’re going to find the mainly in animal based products. So for amino acids are much more rich from animal than you do plants. A lot of plant based products tend to be lower in sulfur amino acids and you actually have to combine them to even get them appropriately right. That’d be like rice and beans, right? Because they’re missing certain amino, so you got to combine them just right. So glutathione really important try peptide, glutamine, cysteine, glycine, glycine, very, very high in bone broth and collagen. Right. cysteine very high and a lot of high quality animal products. Also whey protein. Okay. And then glutamine is obviously in a lot of gut healing supports glutamine is really important for the gut lining. Glutamine can also be more inflammatory, too. If you don’t have enough B six, it can go down glutamate pathways without B six. So we also want to make sure we’re getting enough B vitamins and we’ll talk about glutathione metabolism. We’ll talk about some of those pathways and what nutrients are needed to maximize glutathione and healthy glutathione metabolism besides just those try peptides, glutamine, glycine, and cysteine. Any thoughts seven?

Evan Brand: Yeah, I think it’s all excellent. I look forward to breaking it apart more. Now, how do we measure glucose ion? One way is we like to look at organic acids testing. There’s not a direct marker that says, glutathione, boom, that’s your level. But using some of the metabolites that you can measure in the urine, you can get an indicator of it. And we know that when people are exposed to toxins, whether it’s mold, or heavy metals or pesticide or herbicide, whatever it is, you’re going to be reducing your glutathione levels. And as you mentioned, you know, people that are on veggie based diets, they’re probably going to show up low. And so we can measure that on the oat test other other ways that you know, have to measure glutathione or is that what you use?

Dr. Justin Marchegiani: So yeah, the big ones, like you mentioned are going to be the pirate glutamate. The sulfate and the alpha hydroxy butyrate. Those are going to be some of the best ways to test it on the organic acids. Those are precursors to solidify own and a lot of the the sulfur nutrients cysteine, glycine, glutamine, those are big, big ways to do it. So when you look on the organic acids section, it gives you about five different organic acids that are that are very, very helpful at looking at glutathione the big three of the ones I just mentioned, I’ll pull up a couple others that I use as well, that are more on the precursor side for glycine. So glycine is another big one. Because that’s really important for glue to found as well then there are others that look at glutathione than the cysteine and the glutamine on top of that I’ll pull that up in one second. So organic acids are great. There’s also a red blood cell glorify on that you can do doctors day that does it. I think spectra cell does it.

Evan Brand: Have you ever done it or do you run it or do you think it’s not worth it? If we’re doing that oat.

Dr. Justin Marchegiani: I think if you already have a good look at the oat, there’s four or five markers on there that you can elucidate from so I think the oat’s fine, but if someone has a chronic condition chronic detoxification issues, I don’t think it’s a bad way to just kind of give it a an extra look, see, especially if you’re struggling on the organic acids, or if the organic acids look good, but you’re still having some detoxification issues, I don’t mind running it. A lot of times I’ll run an ion panel with some of my patients which will come with an organic acid and a intercellular nutrient blood test as well. So it would be on there and then also be on the organic acids so that’s a way to kind of get a package deal on and kind of get two for one if you will.

Evan Brand: Yeah, I love the combos. Love the combos yes to like you mentioned the, like vegetarian sources where people are going to get sulfur to boost glutathione. I mean, that’s going to be the cruciferous stuff. This is why you and I will use some of these like broccoli sprout extracts. There’s some kale sprout extracts, things like that. There’s different greens powders, and there are some encapsulated products that we use and I’ve used them with children were if they weren’t able to swallow or they couldn’t stomach like a encapsulated glutathione or maybe alive was almost like they didn’t like the taste and some of the broccoli sprout extracts tend to work pretty good.

Dr. Justin Marchegiani: Totally and on the organic acid just to highlight sulfate and pirate glutamate are the big ones for glutathione that’s really big. And then the other ones are going to be to methyl hip right we’ll really look at glycine and then the gluco re also looks at glycine so those are some of the other ones that can be ultra ultra helpful.

Evan Brand: This is why oat test is like I don’t know desert island you only have one test to choose from between like a DNA stool and an organic acids. Oh, man. It’s tough. I mean, I some days I go with the oat over the stools, my only test if I had to pick one.

Dr. Justin Marchegiani: Well, it can be helpful because you get a good window into yeast and fungus, which can be really helpful. So that’s really nice. And then also, we can talk about gluten if I own the different conditions that are associated with their other nutrients that help you recycled modifying and that are very helpful in the healthy metabolism of fluidify own and we have a nice handout here. I’m going to pull up so you guys can see I think it’s under Very, very, very helpful. I’ll pull this up here for you guys to see. So there’s a bunch of different conditions that are associated with low glutathione. Everything from aging to all simers to cancer to chronic liver, cognitive issues, cystic fibrosis, diabetes, hypertension, any immuno deficiency and chronic viral issues, lupus, mental health issues, multiple sclerosis, neurodegenerative issues, Parkinson’s, I mean, this is like through the freaking roof. It’s unbelievable. The association with other conditions, it’s not saying this is a direct cause they’re just saying, hey, they test a lot of people for who to die on. And they just find this chronic association with these issues. Now, I would say there’s definitely going to be there’s definitely going to be a causation link there for me, it’s hard for research to say that it takes a while for research to do a causation thing you got to do a metabolic war and you got to really take people in, give them Low, low defiant take people out, give them some glutathione and study the different it’s really hard at metabolic Ward studies are tough. So it’s you have to kind of look at more of associative studies versus metabolic Ward that really give you the causation. Let me show a couple things here for you guys to see. me pull this up for you guys.

Unknown Speaker: Okay, can you see my screen Evan? 

Evan Brand: It’s loading. Yep, there it is. 

Dr. Justin Marchegiani: Okay, cool. So these are a bunch of the conditions here that are associated with low glutathione. And then there are the links here. So you can actually see the scientific studies right Alzheimers, the emerging role of glutathione and an Alzheimer disease, right? You can see diabetes glutathione synthesis is diminished and patient with uncontrolled diabetes is really important. And again, this is the article right here I wanted to highlight is called a review of dietary phytonutrients for gluten support. It’s in the journal nutrients September 2019. So pretty, pretty fresh study. But this pathway here I really wanted to highlight for everyone. I think this is super important. When I get this just the right size, does that look good to you? 

Evan Brand: Yeah, looks perfect. 

Dr. Justin Marchegiani: Okay, cool. So let me kind of highlight a couple of things that are happening here so people that are listening, we got a video on screen so you guys can actually see the different pathways and how glutathione gets into the cell and works. So you have your three major amino acids you have cysteine right here, which can come from an acetylcysteine and can get converted from cysteine assisting right there, you have glycine, right very high and collagen and bone broth. That’s why I like to do my 20 grams of collagen in my coffee every morning. Okay, and then you have your glutamate or glutamine inside the cell. So outside the cell, these are the big two amino acids and then inside the cell, you have your glutamine that gets conjugated here. Now also outside of the cell, look at the the green vegetables right the brassica vegetables, the high cruciferous vegetables. Some of the polyphenols like green tea are very important in this glutathione to conjugated, basically it helps conjugate a lot of these foreign chemicals xeno biotic means foreign chemicals, you know, biotics could be xeno estrogens that could be xeno neurological things from pesticides right? So basically they’re going to be chemicals that are foreign to the body that are stressor on the body this can help with fluidify on to GST and conjugate Gosh, conjugate just means binding a protein to it, typically, so the body can excrete it via the stool or the kidneys or urine, right?

Evan Brand: Now, here’s the thing. You mentioned that big list of conditions so it would make sense why cancer would be associated with low glutathione because this pathway you’re showing if you’ve got a build up of all these toxic chemicals and hormone disrupting chemicals whenever if that pathway screwed up. I mean, it sounds like you’re going to end up sick so it’s not that like you said, it’s not causation, but that pathway could be you know, if I were somebody like focusing on an anti cancer regimen, I mean, this pathway here would be a huge piece of the puzzle.

Dr. Justin Marchegiani: 100% and this GST stands for glutathione S transferase and they’re actually making drugs that are glutathione s transferase in nature. So this GST is very very very important in excreting toxins and crap outside of the body. And we know this to like a lot of the things we may use on the brassica vegetable side, we may do broccoli sprouts, we may do sulfur rich compounds like dim, which is di n Dom methane, or we may do indoor three carbinol these are all going to be so for concentrated compounds, we may even do things like calcium to glucose rate. And these can help improve this clarify own clarify on s transferase pathway. Any comments there? 

Evan Brand: I’m trying to figure out what the I would love to learn about that you’re saying they’re using or they’re making prescription drugs to work on this pathway?

Dr. Justin Marchegiani: Yeah, so let’s um, let me see I can pull it up here on screen for you. Can you see this right here? 

Evan Brand: We’re still on the image we still see the image of the pathways.

Dr. Justin Marchegiani: Okay, let me just pull this up here this is an older study but you know I like to just show people what’s going on so they can actually see it 

Evan Brand: Because here’s if they’re gonna make a prescription here’s what they’re going to do they’re going to jack up the price 1000 X to do the same thing that in AC or DC now do yes sir.

Dr. Justin Marchegiani: Okay, so you can see this the role of fluidify on s transferase. In anti cancer drug resistance. So it seems like this may be helping a lot of the cancer drugs work better. So they’re talking about who defined as transfer rates are a family of phase two detoxifying enzymes that help catalyst catalyst is a gluten independent enzyme. And it basically helps when I say conjugate that means bind a protein to it, a variety of endogenous and exogenous toxin. So endogenous means toxins that are made by your body. exogenous means toxins that are come into your So think of mold and pesticides as exogenous. Think of maybe yeast overgrowth or bacterial overgrowth and those toxins being produced like acid aldehyde, maybe being endogenous. Does that make sense? 

Evan Brand: It does. I actually found something on this. I’m looking on this drug website, and actually found out here that for chemotherapy, doses of 1.5 to three grams of glutathione have been given in a 15 to 20 minute time period right before a chemotherapy treatment.

Dr. Justin Marchegiani: Totally makes sense. Yep, totally makes sense. So I’m trying to go down to the conclusion of this one study here. I haven’t gone through it yet. Yeah, I’m just trying to look through this here. Alright, cool. I’ll have to go through this here later on. But I mean, it just shows you how important glutathione is with detoxification, cancer and also we can talk about the immune system, right. There’s the reason why that page had immune issues, AIDS and viral issues as being a low glutathione issue. Because gluten has a major, major role in immunomodulation and immune balancing any comments there?

Evan Brand: I just wonder where this conversation is happening in an oncology office though, hey, we need to boost up your clue to find out I want you to eat broccoli sprouts and take some extra NAC and vitamin C and some of the stuff we’re going to get into. It’s like, Where’s that happening? I mean, maybe in a holistic oncologist office, but I feel like your conventional guys, it’s still just the chemo model. It’s not going to be anything like this. Exactly wrong. If you’re, you know, cancer doctor out there, then let us know who you are, what you’re doing. We’d love to hear about it.

Dr. Justin Marchegiani: I mean, the problem is, people on the pharmaceutical side or conventional medicine side, their perspective when they look at things is how can we make a drug that modulates this pathway or interacts in this pathway? The problem is once you start making the drug, you’re forgetting why these pathways are low to begin with. Right? Hay diet issues, digestion issues, stress issues, exposure to toxins, right They’re forgetting why these pathways are low to begin with. And then number two, anytime you make a drug, you can’t patent Mother Nature. So you can’t patent the actual codify on building blocks, you have to do isomers, or different substrates that look similar, but may not be the real deal. And the problem is once you start deviating from Mother Nature, all drugs have what Evan?

Evan Brand: They have side effects, side effects. It’s like the designer babies. It’s like, oh, let’s play with these genetics. We’re going to make this baby have this color hair and this color scan and whatever there. It’s not what nature intended. 

Dr. Justin Marchegiani: Exactly. So once you start doing that, then you have an increased risk of side effects. And because you can’t patent Mother Nature, you know, that’s the problem. That’s the big issue. You can’t patent Mother Nature. Therefore, you have to go and create compounds that are isomers that look similar, they may work a little bit will never work as good as the real thing. And then you’re going to have a whole bunch of side effects.

Evan Brand: Yeah, let’s get back to that first paper that you and I have pulled up with the graphic on it because we wanted to go through some things that have been shown to help with this whole glutathione people think just pop glutathione pill in that scene of the day. But there’s and that’s true. You can do that. You could do your oral, your sublingual, your zomo, your intravenous glutathione. But there’s other things along the way they can help, like NAC is a game changer.

Dr. Justin Marchegiani: So let me let’s kind of let’s work from the top and go down. Okay, so we talked about what’s happening outside of the cell, right? We need cysteine. We need glycine, these are really really big pathways. We talked about maybe some of the sulfur compounds in the vegetables, we hit that right now inside. If we go to the top of this cycle and work our way down, you can see folic acid or we’ll just call it full late. Okay? And you can see thf this is tetrahydrofolate and this goes to mthfr. Right everyone talks about methyl tetrahydrofolate reductase right mthfr right. So you need full A B vitamins, and then you’re also going to need b 12 betaine, which is trying methyl glycine, so these are important nutrients that are needed. So this pathway can go around and essentially when you have an mthfr issue, this pathway up here, this enzyme is lower. Therefore, you need more of these nutrients here to run this pathway and of course not folic acid we activated fully, whether it’s cat you know, folic acid or calcium D fully or mthfr folate, we need to activate it fully. And then you can see here I’m assigning gets stuck as homocysteine if we don’t have enough of these nutrients and we know homocysteine can create vasculature inflammation, inflammation in the vasculature right? associated with heart disease. You can go look at the research of Kilmer McCauley over at Harvard, and we need enough of these nutrients to take pining to go to homocysteine and then go all the way down to cysteine down here so then you can see cysteines are really good sulfur amino acid cysteine then binds with glutamate or glutamine. Okay, and then you can see cysteine and glutamine go downstream to actually make glutathione and guess what else you need? Well, you know, if you look at some of these nerve pathways over here where you know, you know that multi level product called Protandim, right, it’s got a lot of the phytonutrients the green teas ashwagandha fits in this category, a lot of bioflavonoids like resveratrol, vitamin e omega three and guess what? Magnesium. So these nerf two which is really important for binding that cysteine to the glycine and making glue to find magnesium is really important as well. And then you can see glutathione also is very Selenium dependent. So fluidify on gets utilized in the body, it needs to be two and then also when it gets reduced to reduce go to diet, it needs vitamin C and lipoic acid to bring it right back up and to recycle it. So if you don’t have enough vitamin C or lipoic acid, which is a silver component, we may not recycle our glutathione and then Selenium is very important too because Selenium helps take the metabolism of Go to found it spits out a lot of hydrogen peroxide right here, h2o. And Selenium actually binds an oxygen off and makes it water. So it actually helps the metabolites of glutathione that are very inflammatory h2o to and it turns it in the water. And then we use a lot of these phytonutrients as well to buffer that oxidative stress.

Evan Brand: It’s beautiful. It’s a it’s amazing how that happens. So you and I’ve talked about autism and behavioral issues and detoxification issues and all that and how it’s related to mthfr defects. So what we’re kind of showing here can show how just simply improving the methylation component of this picture can improve detox because methylation helps with detox on its own, but you see the mechanism downstream of glutathione. So this is why some kids that we work with even just by improving methylation, and as you mentioned, we’ll give them like an activated, you know, l mt hf or something similar data We’ll clear up some of the mood issues that will clear up some of the skin, it will clear up dark circles under the eyes. I mean, just improving methylation alone could be a game changer. My favorite part of this whole picture is the vitamin C, because in this paper that you and I were looking at, it was shown that even just taking 500 to 1000 milligrams a day of vitamin C for 13 weeks. So what’s that give it three months or so led to an 18% increase in gluten ion levels? So that’s it. That’s such low hanging fruit. You and I are such huge fans of addressing low hanging fruit. I mean, how much easier can it get? You’re boosting Bluetooth on 20% just by vitamin C. I’m rounding at 18 but I’m calling it 20. I mean, it’s close enough.

Dr. Justin Marchegiani: I wanted to highlight this one study here so you can see it to kind of just dovetails with everything we’re talking about. I want to just make sure that makes sense. pull this up screen here so you guys can see it.

Evan Brand: Okay, while you’re doing that, I’m going to just keep ranting about other nutrients. So yeah, I just pulled up Selenium. I want to say one thing about that real quick. So Selenium. It was found that beautify on increases just by giving Selenium as well. So I’m not saying spot tree. But let’s see someone had a thyroid issue were like, Hey, you really need some extra selenium, that alone could be boosting Bluetooth ion. So it’s really, really cool.

Dr. Justin Marchegiani: And the nice thing is when we’re looking at patients, we’re testing all these nutrients because of course, yes, it’s going to help but if you’re deficient in one nutrient over the other, that nutrient could be the bigger linchpin for supporting your glutathione. Right. Now, this study, I thought was really important because one of the major mechanisms of glutathione and how it works with cancer is it modulates the immune system, better immune system, right? It controls cancer cell growth, right? What’s cancer just cells growing out of control, and then it helps with oxidation, right? oxidation is when you lose electrons and cancer is very oxidative. It causes a lot of loss of electrons which then creates a lot of free radical stress and damage. To the DNA into the immune system, so really powerful abstract here, role of fluidify on and cancer progression and chemo resistance which means resistance to chemotherapy. It talks about codifying, placing an important role in the cellular process, including proliferation and a pop ptosis. That means cells growing and cells dying, so it helps cells so they don’t grow too much until they die sooner. That’s good. We need that. Then it talks about while glutathione deficiency or decrease in glutathione ratio leads to an increase in susceptibility of oxidative stress. What does that mean translation, you lose a lot more electrons, and that creates free radical damage and DNA implicated in the progression of cancer elevated glow to final levels increase the antioxidant capacity. That means it helps you take electrons that you’ve lost it helps bind to them and stabilize the cell and resistance to oxidative stress observed in many cancer cells. The presence highlights the role of gluta thiam as a cytotoxic That means it protects the cells from being damaged. Carcinogenic means means the formation of cancer. So it protects cells from being inhabited by cancer and the sensitivity to tumors to the cytotoxic agents, or the cytotoxic effects of anti carcinogenic agents, so what that means it’s going to protect you from getting damaged by chemotherapy. And it’s going to protect you from the cytotoxic effects of chemotherapy. So that’s kind of the the layman’s translation as we go. So what’s the moral of the story glutathione protects you from the damage of cancer, it protects your cells from growing into cancer and it protects you from the damage of chemotherapy. So three ways it’s very beneficial.

Evan Brand: That’s amazing and not that this was the glutathione cancer podcast, but hey, I’m sure everybody listening would agree that you don’t want cancer. So, of course, you can’t say glutathione prevent you from getting it, but man, it’s an incredibly protective molecule.

Dr. Justin Marchegiani: 100% Evan, can you see me back on screen now? 

Evan Brand: Yes, sir. 

Dr. Justin Marchegiani: All right. Awesome. I think we hit that one really, really well. Let’s keep on rolling though, if you don’t mind. So we talked about that pathway, which I thought was really helpful. We’ll put the links down below. So if you guys want to see it, why don’t we talk about some of the big foods, so beautify on right cysteine glutamine glycine, so now we just back into it what foods are really high in cysteine, glutamine lysine? Well, of course, things like whey proteins and to be great as long as you’re not ultra dairy sensitive whey proteins great sulfur rich foods are going to be helpful like a lot of your brassica cruciferous vegetables right bok choy, broccoli, brussel sprouts, cauliflower, kale, mustard greens, turnips, again, the problem is that’s not going to really help you with a lot of the intercellular glutathione but it’s still going to be helpful. Now what other other foods that are more high in some of those intercellular nutrients? Well, you’re going to see all of your high quality animal products, beef, chicken, fish, eggs, all of these things. The higher quality the animals are, meaning the less hormones the West junk, the less toxins, the more they’re fed high quality grass, the more nutritionally dense they’re going to be.

Evan Brand: I found, I’m looking at a couple of like food data sheets. So in one large egg, you get almost 150 milligrams of cysteine. And who knows if that’s even, I mean, that could have been a conventional egg. I mean, what about like a fully pastured organic egg, you may even get more cysteine you’re talking almost I mean, if you do two eggs, you’re at 100% of even over 100% of your daily intake for assisting with two eggs. Love sunflower seeds, and a handful, a one ounce handful of sunflower seeds. You’re at over 100 milligrams of hemp seeds. You get a ton from hemp seeds as well. So like let’s say you did a smoothie in the morning where you put in some collagen with maybe some hemp seed or maybe some hemp protein added to it. Maybe a grass fed way. I mean you’re going to be stellar in the solidify on generating department.

Dr. Justin Marchegiani: Love it. 100%. So your animal products are always going to be the best way to go off the bat just because of how high they are and how nutrient dense they are. Also, when you look at amino acids and plants, you have to look at the digestibility of the amino acids, there are certain scales, you can look at that look at the digestibility because plants have a lot of anti nutrients that bind a lot of these amino acids up because plants don’t have claws and teeth to fight or flee. So how they survive is they have anti nutrients which makes some of their nutritional compounds harder to break down which means they pass through the stool and then they can grow seeds and flourish and other parts of the soil. So they have to have anti nutrients so they can pass other animals digestive tracts right. Animals just have claws and teeth to fight and flee plants don’t so there’s a lot more anti nutrients that prevents some of the digestibility whether it’s mineral blockers like fighting And oxalates, whether it’s trypsin inhibitors that help decrease proteolytic enzymes, so their proteins can’t be digested, whether it’s lots of hard to process fibers, all those things are potential and could be, could play a big role in those amino acids not being fully absorbed.

Evan Brand: Well, here’s a couple other things, too. So in that paper, they’ve got a table on there that talks about preparation of the sulfur rich vegetables. And apparently freezing of broccoli does reduce the sulfur. And then of course, if you are eating it overcooked, you’re likely gonna it’s like a sweet spot, right? Because we’ve talked about this before nutrient density of raw versus lightly steamed. So lightly steamed is going to be the way to go. But if you cook too much, then you’ve broken it down that way. If it’s frozen broccoli, then you’re already at a disadvantage state. So it sounds like it’s just too difficult. I mean, I’m not saying that. veggies aren’t important. I still eat a ton of veggies, but if I’m looking to it To increase glutathione I’m not just going to be doing a broccoli smoothie, I’m going to be focused on the way and the collagen. And also, here’s an interesting one. Number one food for my pining king crab, one crab leg, you’re over 700 milligrams of Matheny. It’s the number one source. So if you like crap out there, there’s a reason to like it because of them.

Dr. Justin Marchegiani: Love it. I love it. I think that’s really, really awesome points. So a couple of kind of deal breakers, let’s call it low stomach acid, we don’t have enough high quality stomach acid, it’s gonna be hard to break down a lot of these sulfur rich compounds. So of course, that’s going to be a big, big problem. So if we don’t have enough stomach acid or enzymes, we’re not going to be able to digest a lot of those animal products, and also a lot of the sulfur rich vegetables. Let’s be real, a lot of them are very high and fodmaps, right, fermentable oligo, disaccharide, mono and polyols. So guess what, if you have SIBO guess what kind of response to those vegetables you’re going to have? Yes. A lot of bloating and gas, they may even disrupt motility they may even cause diarrhea or constipation. So you may not really be able to tolerate much of these vegetables. So a lot of people that are like on a carnivore template, a lot of times they have SIBO, and a lot of autoimmune sensitivities and they’re really sensitive to a lot of the anti nutrients in these plants. So a lot of people kind of come down on people that are doing a carnivore template, but the reason why they do it is because they feel significantly better because of the anti nutrients and because a lot of times there’s some SIBO going on and cutting out those fermentable carbohydrates or even going carnivore can help starve out some of those critters too.

Evan Brand: Yeah, and important. And let’s point out that’s not forever. I mean, if somebody is on a carnivore template, we’re using that to stabilize those people until we can work behind the scenes on these other issues like the infections you mentioned. Yep.

Dr. Justin Marchegiani: And we may be able to add some other things down the road for sure. So a lot of your vitamin C rich vegetables are going to be awesome. A lot of the sulfur ones a lot of the lower sugar fruits are going to be awesome. Those are going to be great things to do off the bat. Of course, we talked about yourself. Millennium rich foods as well animal products, oyster seafood, high end zinc high in selenium, Brazil nuts can be excellent as long as you can tolerate the knots very, very high in Selenium. We talked about the stomach acid and the enzymes as being a rate limiting factor because of the fact that they need good acid levels and enzyme levels to be able to break them down. And also say we talked about this earlier. Vitamin D is really important for glutathione in the brain. Can you talk about that a little bit, Evan?

Evan Brand: Yeah. So I think the best way to talk about this and implement it is through the nebulizer. So there was a couple papers talking about increase included found in the brain. I don’t have it pulled up. But long story short, I’ve looked into this. I’ve done it over the weekend. I will tell you, I get more energy, I get more mental clarity. I feel honestly I feel relaxed. I mean, it’s almost like I snuck in a little bit of gamma powder into my nebulizer something because after breathing in the glutathione, I just felt relaxed. Maybe because I was like focusing on deep breathing and such while I was breathing it in. But I looked at a couple papers on the administration method. So just eating glutathione orally meaning in a capsule form like zomo, doing foods to increase it versus IV versus nebulized. The only way to get it in the brain is nebulizing. At we’re talking at therapeutic levels now, the some of the glutathione made in the body get into the brain, probably, but we’re talking if you want to just crank up brain power, let’s say you have a traumatic brain injury, maybe you had a head injury or you’re an athlete or a soccer player or you fell off a bike or you fell down a set of stairs or you have mold because we know mold damages the brain to me nebulizing with the sodium bicarbonate and the saline solution. It’s a miracle cure, so I can’t say enough good things about it.

Dr. Justin Marchegiani: No, I love it. I think it’s really, really important. I wanted to highlight a couple more things that I thought were also very important. Let’s talk about supplements. So we talked about a couple things when we review that solidify on pathway that you guys can see the video on. Alpha lipoic acid is very important in recycling clarify him. Also, milk thistle is a really good tone of fire and does help support glutathione levels as well. Vitamin C is really important, right? That helps with reduced glutathione and help activating it again, that was also very, very important. Oh-

Evan Brand: Here’s one thing. Go ahead. Here’s one thing I forgot to mention this was in the paper. So I kind of went on a tangent on the on the nebulizer. But in that particular paper, you and I were discussing it I was wrong. It is true that you can increase at least this was in rats. So is it the same in humans maybe. But by just giving an IV dose of NAC they were able to increase glutathione in the brain. So what about oral NAC? Does that increase glutathione in the brain? I don’t know. But at least in that paper IV NAC did boost Brain levels include glutathione.

Dr. Justin Marchegiani: That’s great. Yeah, I imagine over time, I mean, those amino acids will eventually cross. I know sometimes the amino acids cross the blood brain barrier and then the glutathione converted in the brain I think glutathione maybe too big to cross the brain itself. I know some of the amino acids like cysteine Oh l cysteine. can cross the blood brain and can then convert to glutathione in the brain. So I know cysteine is a big one. I don’t think NAC can but l cysteine can. 

Evan Brand: You think just because it’s smaller? 

Dr. Justin Marchegiani: Yeah, smaller because NAC gets broken down into cysteine by the body and some people they say just take cysteine because I know a lot system is very important with adrenaline. And we know adrenaline is a really big, nervous system. amino acid right? And we know dopamine actually gets converted to adrenaline and we know dopamine to adrenaline. That pathway involves sulfur in particularly cysteine.

Evan Brand: So wonder, I’m just thinking out loud just for for my purposes. So I want to People that are having issues with anxiety, if they would be able to reduce the anxiety by boosting up that pathway working more on sulfur.

Dr. Justin Marchegiani: Sulfur can be really helpful. Now in my line, I have a product called detox and he knows that we’ll have some cysteine some and acetylcysteine some calcium to glucose, which is a really good binder for mold and for hormones, refining, cysteine, taurine, glycine, so all the amino acids which is really helpful, I like that a lot. I’ll also do a lot of the the phase one nutrients, a lot of the antioxidants, a lot of the B vitamins, milk thistle, those kind of things for phase one support. Phase One is taking toxins that are fat soluble and converting them to water soluble phase two is going to be water soluble, excrete it out the body and that involves lots of sulfur, all the amino acids I just mentioned. And with some people we may do a combination of El glue or lipids almost glutathione we may do glutathione, there’s another good found has these little these little Bucky balls? Can you talk about that?

Evan Brand: Oh, yeah, I love I love the seat elated. Yeah, so there’s a couple out there with the Bucky balls that basically the idea is to try to just shrink the molecular size of it, so you can kind of sneak it into the cell. So there’s, you’ve got the light zomo where you’re going to do like a sunflower and then you’ve got this buckyball idea now I don’t know if it’s a carbon molecule, if this is the same thing as the C 60. You and I’ve been talking about or what but but there are ways to to make Bluetooth ion smaller for me, I just look at the papers on it. And the acetal version is the one that I believe you have your own I have my own as well have an S acetal ad glue defi on. I’ve had people doing here just just a quick little debate. I’ve had people doing various versions of like Bumble glue defy on and liposomal vitamin C and I’ve measured them and many of these people are still low on the test for vitamin C and glue to violence. So when we switch them over to like an acetal ated and then just a mixed ascorbate I see the levels come up so it’s not that I’m against the life was almost glutathione. But I’m just finding that the acetal works just as good if not better, and it’s capsule because the lipids almost generally tastes like crap. Or if you’ve got a really sensitive person, there’s going to be citrus oil or some other flavoring to cover up the terrible beautify on taste. And then those people don’t tolerate it, and then they’re not compliant and then they don’t get better.

Dr. Justin Marchegian: 100% Yep, I totally agree. So right now, I use a lot of lipids almost, but you still do the seagull and you still get good results with that clinically?

Evan Brand: I do. Yeah, it works great. And I feel good on it. So I’ve done an experiment on myself where I’ll go life as normal for a month and then I’ll go acetal I feel just as good Now it could be because my acetal version has a gram of NAC added to it. So I’m kind of cheating because I’m really getting the NAC plus the gluten. Maybe that’s why I’m I’m getting so much better. Oh, so while you were talking I just did a quick search on studies on glutathione and anxiety because you brought up this whole dopa mean endorphin thing and this is not for the podcast, but really more just Brain Candy for me. Turns out Yes, there’s a link between glutathione and anxiety and bumping up glutathione been shown to reduce depression and anxiety. So there you go.

Dr. Justin Marchegiani: I make a lot of that has to do with the catecholamine. The dopa means synthesis in the brain. So I think it’s really really important to know. Dr. Marty hands I think he’s over at neuroscience or neuro research. He talks about how sulfur is very important for synthesis of serotonin and dopamine and a lot of your adrenaline over time you will deplete it, especially when you get stressed and you’re taking a lot of your dopamine and you’re converting it downstream to adrenaline, you will be depleting a lot of your sulfur. Now, what does this matter? So this matters, because the more stressed you are, the more sulfur you deplete, which means you’ll have less sulfur leftover. So now if you’re stressed and now you’re exposed to toxins, or you’re living in a moldy home, you can see how stress can make everything worse because now you have less flow glutathione precursors to help you in that situation. 

Evan Brand: Yeah, speaking of stress, I’ve got a paper in nature right here. was called I’ll give you the link in case you want it in case you want to show anybody but it was called glutathione depletion, mitochondrial dysfunction induced by chronic stress. And I don’t know this is a rat thing so you know how they deal with rats they do something to them to stress them out but long story short stress in this paper had reduced glutathione brain glutathionr by over 35% so it would make sense why glutathione would help with depression too because you think about the toxicity I mean, heavy metals and such those can impact neurotransmitter function you can get depressed just for being toxic. So by reducing the toxicity, you’re less depressed. I mean, I think that’s really cool. 

Dr. Justin Marchegiani: Exactly. Now a lot of people are asking well where can you get the nebulized glutathione right now the third natural site is sold out but would be where you can find that as the third natural site if not head over to or just put glutathione in the search and we have some of our own sulfur based compounds that we use in the lead As well mold based compounds we use so feel free to reach out to us, we’ll put pertinent links down below for you guys as well. And then outside of that, just really make sure you have good stomach acid levels because you need good stomach acid to break everything down. And then we also talked about, you know, the animal products if you’re vegan vegetarian, try to get some animal products in there, even if it’s egg yolks, or if it’s a little bit of fish, do your best on that and just try to make it healthy. And then really look at B 12. And fully, you’re not going to get enough b 12. On the on the plant based side, you really need animal products to get b 12. So if you are really plant based, you need to make sure you’re supplementing with the high quality methylated B 12. And maybe some activated full layers to be safe, because you need full eight and B 12 to run those glutathione pathways.

Evan Brand: Let’s just do like a quick 30-second recap because those with brain fog are like oh my god, what am I supposed to do? Do I go like swimming? Am I in a pool filled with glutathione? What do I do? So whey protein, grass fed meats Good cruciferous veggies probably lightly steamed over raw, maybe some greens powders or greens juices if you if you just for some reason can’t tolerate it like the broccoli sprouts, I think that’d be great for somebody that can’t eat broccoli because maybe they have digestive troubles and you could go for some of the extracts, making sure you’re doing enough vitamin C as you mentioned, adequate stomach acid, so making sure you’re testing your gut for infections. If you have H. pylori, and other infections, you’ve got to fix your gut, so possibly extra enzymes, possibly anti microbials, antifungal, anti parasitic herbs to treat the infections, maybe doing an oat test to check in on your overall levels and getting some micronutrient panels run. And then if there’s other issues that are keep depleting you then maybe looking into the mold, the heavy metals and the other toxins that are going to deplete glue to die on. That’s kind of your recap.

Dr. Justin Marchegiani: 100% now, what do you need for sulfur amino acids a day? I would say you know 1500 to 2000 milligrams on some of the NAC and some The sulfur aminos I’ll do one to two scoops, you know, 1020 grams of collagen a day, I think it’s great on the vitamin C on the low side, you know, one to two grams, I think it’s great if your diets amazing and you’re getting lots of leafy greens and some low sugar fruit, maybe a gram or nothing is probably okay, if you’re really great there, if not a gram or two on the vitamin C sides are great on the light bulbs almost go to file. And if you want to go that road, I think half a gram to one full gram is fine half a gram on the maintenance side. Or if you’re just getting sulfur amino acid, that may be enough. But if you’re under some stress with mold a half a gram to a full gram. And if you’re dealing with more acute stress, right, a lot of viral issues today can really create stress in the lungs and glorify them can be very helpful with that long stress. You may want to go up to two grams on the glutathione more acutely and those are a couple of good first things go ahead.

Evan Brand: Yeah yeah don’t forget about the NAC too. You and I did I don’t know if we did a whole show or if we just kind of rained it on it for a little bit, but NAC in regards to immune health and NAC being very very protective so I’m usually at around a gram but you could go higher possibly 2 grams per day of NAC combined with that 500 to 1000 milligrams glutathione that is an awesome one-two punch. 

Dr. Justin Marchegiani: Yeah, just be careful what the NAC cuz it’s an expectorant it will dry out your sinuses and and your throat a little bit so it’s great if you’re really mucus ease but be careful if you’re getting too dry you may want to pull back on it. So just kind of know that NAC is awesome for a lot of the excess post nasal drip excess mucus but if you go a little too much you may get a little bit too dry in some of those areas.

Evan Brand: I can confirm. I haven’t had a nosebleed but when I was going higher like, two grams. Yeah I was pretty dry I felt like I could breathe better though, man I tell you my sinuses felt clean as a whistle.

Dr. Justin Marchegiani: Yeah, so if you’re getting over a cold and you got a little bit of post nasal stuff going on, NAC you should be one of the first things you go to in your medicine cabinet specially if you get that little bit of a nagging post nasal drip cough and they cease the first thing to hit.

Evan Brand: Yep.Maybe that some Exley or nasal spray something like that you got anything.

Dr. Justin Marchegiani: Oh yeah, well you definitely the sign is flush with the X clear like that’s number one, because you got to flush things up, and the number two, you dry it up and then you do those you’re in good shape. Anything else you want to highlight Evan?

Evan Brand: No, let’s wrap this thing up it was fun and if y’all have further questions or comments of course we always want to hear your experiments and your experiences- how did it go, what did you do with glutathione, did you do like me and then I called Justin in like 10 o’clock when I hey man I took like a double or triple dose of glutathione and I got a terrible headache I remember that so now. We’re always being the guinea pigs and that’s what we love doing and we are available clinically. So if you need help, you can reach out to Dr. J at, we work with people around the world. So, my website and we’ll be in touch next week.

Dr. Justin Marchegiani: And when we talk about these things guys, this isn’t theoretical for stuff. We see thousands of patients, tens of thousands over our decade-long careers and we know it works. We know it doesn’t and if you’re leaning into glutathione, maybe put a little bit of a binder in there an activated charcoal bentonite clay taking way away from food and supplements just to kind of soak up or kind of broom up anything that may be already liberated from your body. So that’s kind of a good first step just to be on the on the alert and always start low taper up don’t ever go over the top on it always start low work your way up try to make sure you’re working with a

practitioner so you have ways to monitor, test and assess as well as figure out the best order of operations and addressing your concerns. And if you want to reach out to Evan,, myself Dr. J We are available worldwide for support and health consults and feel free and reach there. All right guys if you enjoy it let your friends and family know put your comments down below and what future podcast topics you’d like to hear about. Have a good one guys, take care.

Evan Brand: I got one final comment on that sure, I’m so glad you brought up the binder. So this podcast is not designed for people to go, hey I’m you know feverishly writing down everything that Justin said. This many milligrams of this is I’m gonna go do his protocol- no, that’s not what he said. These are just guidelines okay because if you go and you do a gram of glutathione and you’ve never taken it you’re probably gonna get a headache or feel like crap because you’re mobilizing things. This thing glutathione helps push and I think of it as the push so when we’re talking about a detox protocol it’s kind of a push catch push catch repeat and if you don’t have something in to catch it meaning something to upregulate phase 2 or potentially also in addition the binders like the charcoal the clay zeolite bentonite you know chlorella whatever it is you could get in trouble so please don’t just go to glutathione, you’ve really got to have some sort of catcher’s mitt in place or just help your you know allow your practitioner to guide you because you can have too much of a good thing.

Dr. Justin Marchegiani: Excellent point, Evan. We’ll put some of our favorite products down below so you guys can take a peek and we’re here to help you as needed Evan you have a phenomenal day.

Evan Brand: Great chat with you, take care. See you later. 

Dr. Justin Marchegiani: Thanks, bye.


Audio Podcast:

Functional Medicine Tips to Survive the Holidays | Podcast #262

Happy Monday! It’s the holiday season and everybody is feeling the holiday rush. As much as we are excited for the holidays, it is also important to keep our body sane and healthy. Today’s chat will be all about functional medicine tips and tricks to keep our health, sanity and stresses down in the holiday season. Check out this episode to learn more.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

00:40 Portable IQ Air

5:35 Stave off stress during Holiday Season

14:38 Nebulizing

25:04 Air and Water Filtration for travels

31:34 Tips on Traveling


Dr. Justin Marchegiani: And we are live it’s Dr. J here in the house, Evan, how we doing today my friend?

Evan Brand: Hey man, Happy Monday. I’m glad to be back. I took a week off and felt like a month off. And I was like, God, I can’t wait to get back to work. So I’m glad I’m here.

Dr. Justin Marchegiani: Totally man, I hundred percent agree. So that’s good. We got the holiday season. We are here in the thick of it. I know you were off in Florida this last week trying to get some sun and some good rays. Let’s kind of chat a little bit today about you know, functional medicine tips and tricks that we can do to keep our health and our sanity and our stress down in the holiday season.

Evan Brand: Yeah, so why don’t we start talking about just the travel component and then we could go wherever you want in terms of like herbs to help the immune system and nervous system. I think there’s a lot of cool directions we can take this but I’ll just start out with the air travel because I just got off the plane yesterday. Right? And it wasn’t terrible, but I’m not a huge fan of air travel for many reasons. And one is just The air pollution the fact that you’ve got, there’s no fresh air on airplanes, they’re pumping the cabin full of the research related or recycled air from the exhaust of the engines. And so it’s just really not a good place for fresh air. So what I did and some may say, Oh, this is extreme or whatever, but that’s why you’re listening to us because you want to be the best and you want to be the healthiest you can be. So what I have is the portable IQ air. It’s pronounced autumn, but it’s spelled atom at em. It’s like a desk It looks like a little UFO. And it’s a portable air purifier. We have one in our car that hooks up to the 12 volt outlet. But then we also have another one that we can take for travel and they have a portable battery pack that they sell with it and it fit inside of my backpack, no problem on my carry on bag. And I put this little portable half the air purifier on my tray table on the plane ride with the battery pack and cranked it up on high and you couldn’t even hear it because of the engine noise of the plane. And my my two daughters and my wife and I all got fresh hepa pure air Right in our face, we just angled the vent of it. So it pumped our direction. And the air was noticeably cleaner and more pure. And we’re not talking just filtering jet fuel, you know, you’re filtering potential mold on the plane, you’re filtering out the neighboring people’s perfumes and colognes and all that. So it’s just one simple way to try to reduce your exposure to toxins. And if you’re weak from an immune perspective, hopefully that’s filtering out some bacteria and viruses and other things like that. I mean, I remember, I don’t know if it was this year, last year, whenever it was, I think it was when you went to Mexico and you came back and it was like you picked up a cold from the plane because the plane was Germany or something. So it’s like, I’m not going to say this is a cure all, but I think it’s a good preventative medicine.

Dr. Justin Marchegiani: I like it. So the IQ air the ATEM. Okay, cool. We’ll put some links below. And that’s a good portable one, huh?

Evan Brand: It’s gorgeous to It’s very pretty. You can control it from your phone if you want to. You can you know Turn up the speed turn down the speed, there’s blue light on it that you can turn off. So overall, it’s a very, very good portable setup. And when we were in hotel rooms as well, we would just unplug the battery pack and plug up the wall outlet. And then we would just crank it on high in the hotel room and then boom, by the time you step back in your hotel room, you’ve got real fresh air in there as well,

Dr. Justin Marchegiani: that says absolutely great. And then did you use the atem desk or the atem car or?

Evan Brand: Yeah, yeah, good question. So the car is better, because there is an extra layer of carbon or something involved in the car versus the desk. So I only recommend buying the car version and then you can just use it inside your home as well. That is great. That’s awesome. And then you can bring that with you on trips and then you have that extra bit of air filtration. That is awesome. And could you use it in like a kid’s bedroom or a bedroom? Oh, totally. Yeah, I mean, it was the perfect white noise to for the kids to take a nap. We just cranked it on high and it’s just a nice white noise but then you know the kids are breathing in pure air too. 

Dr. Justin Marchegiani: And can you keep all the lights turned off to?

Evan Brand: yep on the app. You can just go boom, and then the blue light turns off. So it’s just a completely dark air filter.

Dr. Justin Marchegiani: That’s great. Awesome. I like the ones that are small and portable. Some of the ones that I have by the Austin area great, but that, you know, they’re not quite as portable, you know?

Evan Brand: Yeah, you can’t put it in a suitcase, you know, and like, you know, other people, Dr. mercola, he had promoted these like neck things where it’s like a portable ionizer that you wear on your neck, I bought one those things are garbage. This thing is way better. I mean, it’s a hepa filtration versus, you know, people try to say, oh, here’s a negative ion generator that you wear on your neck. It’s like, No, those are so stupid. This is way, way better and more functional.

Dr. Justin Marchegiani: And what does it cost to change out those filters?

Evan Brand: I got an extra filter when I bought it. I think the extra filter was maybe 100 bucks. Don’t quote me on that. Okay, good. And you can monitor the filter life from your app. So it’ll say, hey, you’ve got 89% left of your filter, and then it’ll give you a notification when the filter needs to be changed.

Dr. Justin Marchegiani: Okay, God, that’s cool. So I like the air filtration aspect of I think it’s powerful because Air Quality is important, especially on the airplane. I mean, you know, I think you may only be able to do so much because you have so much recycled air coming through. So, in general may not move the needle too much, but I think it’s really cool to have it in your hotel room, especially people using whole bunch of cleaning products that you know, aren’t as nice. It’s nice to have that good quality air filtration at least in the room. That’s great.

Evan Brand: Yeah, filters out the voc right. So yeah, if you had you know, we did request fragrance free hotel rooms and made sure they only clean with vinegar and all that. So it helped a little bit but filter would help reduce or remove any other voc if you’re sensitive like I am.

Dr. Justin Marchegiani: Absolutely. And we’re really diving into the functional medicine and natural health kind of principles to stave off stress during the holiday season and when traveling and such that’s really the title and the topic of today’s chat. So off the bat we also can be utilizing natural antioxidants to help deal with stress when we’re flying to. I’m always a big fan of when flying or travel or vacation starts. I’m going to be adding in include a phone and or glue to find precursors. This is kind of our body’s natural, very most powerful antioxidant to try peptide antioxidant. And we’re going to use this at higher levels to deal with stress from travel, just the radiation you’re exposed to and traveling. We’re also going to do maybe natural medicinal mushrooms or herbs like a strapless and geographics. akinesia. We’re going to be doing things like this to help bump up our immune system in my supplement line at protocol them, you know, Supreme, and that’s powerful that has a couple of different herbs in there, some medicinal mushrooms and it has some of the stragglers and akinesia that kind of get your immune system right ready. So it’s just kind of getting those natural killer cells up and ready on attention. So if we get exposed any viruses or bugs, we’re more likely to stave off an attack. So herbal support medicinal mushrooms, Reishi, [inaudible], ekenasia, these are going to be very powerful and then of course things to new actually deal with oxidative stress which could be glued, if I own high dose vitamin C, which is going to help include if I own as well. I’d also say you could even add in some natural anti inflammatory support like curcumin, but I’d say if you’re going to keep it simple, high dose kluth iron and vitamin C is going to be very, very powerful.

Evan Brand: Good advice. You know a lot of people post articles and snippets and all that about top 10 ways to naturally fight the flu or top 10 ways to naturally fight a cold, it’s like, well, wouldn’t it be better if you could just keep your immune system on alert, like you mentioned and up regulate these immune system pathways as opposed to getting sick and then now you’re trying to read an article on how to get yourself sick like just if you are on these herbs and your immune systems up regulated, you may not even have to go to the top 10 Natural Ways to fight the flu because you never got the flu because your immune system was so strong

Dr. Justin Marchegiani: 100% so on the vitamin C, you know we’re going to do a couple of grams, so anywhere between two to five or six grams and the vitamins See, again, typically just below bowel tolerance is ideal. So a lot of people will start getting loose stools around six to 10 grams or six to 10,000 milligrams. So somewhere in that two to five, two to six gram dosage range is probably good. You may have to feel it out to see where you sit. And then in regards to Reishi, you know, I’ll go anywhere between two to five grams a day, probably closer to two to three if I’m just trying to like, get my immune system upregulated and I’m not fighting something probably like two to three grams just to be like, Okay, I’m ready to go. And then acutely, I’ll go off to three to five if it’s really acute. And then I would say what the gluta Island probably you know, up to a gram or so a day on the glue to die on and get my immune system kind of hyper regulated and ready to go.

Evan Brand: Yep. And talk about the nebulizer. We spoke about this a few episodes ago, I said, hey, you’ve got to try it. And you’ve tried it. So what’s your what’s your feedback?

Dr. Justin Marchegiani: Yeah, so this is a very powerful tool and a means to get Certain compounds into your lungs and into your bloodstream fast because we know when we get sick a lot of times, you know, we have the ability to control essentially our hands by washing our hands. And we have the ability to control not quite as much what we breathe, maybe if we have a mass, that’s probably the best that we can do. But in general, a nebulizer allows us to take compounds in my favorite two things to us are going to be silver, and we’ll choose a 15 ppm to a 10 ppm or less of silver. And we’ll nebulize that and we can breathe it into our lungs. So we have all of the silver in our lungs, in our sinuses, and that’s going to help kill any bugs or biofilms that we may be getting exposed to so I like nebulizing silver, acutely, especially after a flight or after any exposure to someone because you get the silver in your lungs, and it’s anti viral as well. So the problem is, number one, you don’t want to be using antibiotics prophylactically but number two will not touch a viral issues. So the best thing with the silver is you can knock down some of the virus stuff. And the second thing is cluded I own concluded I own really helps with inflammation. And it really is increased so much more especially in your lungs when you do it when you nebulize it and you break it down to really tiny particle. So with nebulize go to dial and you can do that as well. One you’re getting the Bluetooth ion to help with the oxidative stress. But number two, it’s also going to help with inflammation and it’s going to help modulate your immune response. I’m a big fan of nebulizing the silver and nebulizing the Bluetooth ion is a couple of good nebulize that are out there I have one that’s really small and recommended to me there are two really two or three really good small ones. I’ll do a separate video on this and you take the nebulizer and essentially you use some sodium chloride kind of a nice taylean solution that sterile and then you’re going to add anywhere between a teaspoon of silver of there or you’re going to do about 200 milligrams of glutathione and a sodium bicarb form so it’s an a breakdown. And then you can nebulize that 200 milligrams a load of biome, or that one teaspoon of silver, and you get it directly into your bloodstream and the nebulize go to die on significantly increases in your bloodstream and in the lungs even more than oral when it goes orally. It has to kind of go throughout your body. But when you do it in your nebulizer, it goes right into your lungs, it’s going to help with things in your sinuses, it’s gonna help with all the inflammation in your lungs. So you get it right there. It’s fast and it increases your blood sugar levels so much faster.

Evan Brand: Yeah, not to mention, you can cross the blood brain barrier when you’re breathing something in like that too. So I got to give credit where credit’s due. This whole idea of me getting interested in nebulizers and Bluetooth ion and then trying in and then you and I talking about it, Stephen Buner. He’s like one of my favorite herbalists. He’s written a lot of really great books on Lyme disease and co infections. I believe he’s personally suffering from COPD and, of course, many people out there suffering with COPD so he actually came up with this COPD protocol. And I just took a couple pieces from his protocol which was the nebulizer with the sailing and the glue to die on. Now he’s talking about, I think it’s frankincense and some other essential oils. And he’s doing a lot of these other like Japanese herbs and Chinese herbs and mixing all these in a combination as this big old 20 to 30 p COPD protocol. I don’t have COPD. So I just took the pieces that I thought would help me the most from that protocol and then implemented it and then I had had watched the I don’t know if it was a webinar, what it was about, it was a guy speaking about using silver hydrosol which same thing Colloidal Silver silver hydrosol is the is the right name, and he was using this for lung cancer. And he was putting the silver into a nebulizer for lung cancer and I thought okay, that sounds pretty cool. And then I just mixed them I just thought why don’t we mix silver mixed Bluetooth ion. And as you mentioned, it’s the one with the bicarbonate added so it doesn’t burn your lungs or anything, and it’s a very smooth process I get, and I don’t know if it’s placebo or what but I feel like I get a little bit of a head rush after I do it. Like I feel a little bit more mentally clear, you know, Bluetooth ion is, is said to increase energy levels to right because you’re increasing your detox ability and a lot of times that helps increase energy. So after I do it, it kind of hits me like a wave. It’s like whoosh, and then I feel good for you know, a couple hours after I haven’t had any bad side effects. I don’t know if you have I haven’t had any headaches. I haven’t had any like detox reactions from it. Overall, it’s been very, very good.

Dr. Justin Marchegiani: Yeah. Also, I find it very helpful with kids that don’t want to swallow supplements or take supplements. The nice thing about it is you can don’t even have to put it over the face, you can kind of keep it a couple inches away and just let them read it for a few seconds, and they’ll get it into their system. So I like it because if my son may have gotten exposed to something, I can just give them maybe a minute with a silver, just kind of reading it in or I can give them a minute of the Go to File and I can at least get some good antioxidant support which does help with the immune system, Bluetooth Iowans a really important immune system modulator. And I can also get the silver up there which will help with viruses and biofilms as well. So it’s pretty powerful to have that, especially with kids. And especially with just being around people that are sick, I can get stuff into my respiratory tract fast. And I’m not sure if any studies in this but you know, there’s a lot of times it’s like a one or two, one or a week or so latency period on getting an infection and it manifesting. So I’m curious to know, you may have an infection, it may be an latency period, and I wonder if just doing that preventatively would prevent that infection from manifesting?

Evan Brand: I think it would, right I mean, think about if it’s sitting in the nasal cavity, maybe it’s found a way to hide in some biofilm and the nasal cavity or the sinuses and then the silver comes in and kills it. You know, I think yeah, I think you’re right. I think it could kill it. While we’re on the topic of the nasal cavity area for the holidays. You know, this would apply for people going to a family member’s house where they’ve got air fresheners or plugins are, you know, if you’re a smell smell sensitive person like I am, even if you’re not and you just don’t want that crap in your sinus cavity, you and I really like the x layer, which is the stevia based nasal rinse, or is it Earth return those xylitol, I’m sorry, it’s xylitol. You know, if you squirt that up your nose, I wonder if you could just add some of that mixture to the nebulizer. I mean, it’s the same thing right? You’re squirting it up your nose versus nebulizing I don’t know, maybe overkill, but at least you could use the X ray or nasal spray, boom, boom, a couple sprays each nostril and spit it out. If you end up getting some drainage,

Dr. Justin Marchegiani: what I think is even better, what I’ve been doing is I’ll do the Neti Elixir packet so it’s actual packets and and I mixed it with four ounces of water, clean, filtered reverse osmosis water, and then I squeeze it up one nostril and it goes all the way up my frontal sinus and then back down and I do have about two to three seconds of flow. Then I blow my nose, clean it out and then to the other side. Two to three seconds, and then blow. And then what I’ll also do is if there’s any kind of infection that I’m thinking about, I’ll do the Neti actually or packets because you only can spray, barely anything with the spray. But if I can do the packets, I get constant flow for two to three seconds. And then number two is I’ll add a teaspoon of silver. I’ll add a teaspoon of silver as well to it. So then I’ll have the Neti Elixir with the xylitol in there, and then I’ll see it has the minerals in there to make it more you know, sensitive against the mucosa. And then I’ll add the silver and then the silver goes up and can really kill any viruses or pathogens or biofilms as well. So that’s a double whammy. That better Yeah, and then afterwards, then you can do if you want to nebulize some silver because that way it goes in your bloodstream because it’s not going to really go into your bloodstream, right? But when you nebulize a silver now it’s in your bloodstream and in your lungs. So if there’s any incubating viruses That’s where it’s going to be really, really helpful because then I’m really work on knocking and killing that down. And then you could also nebulize the Bluetooth icon, which I don’t think is anti viral, but it will help with inflammation, and it will have an effect on modulating your immune response for the better.

Evan Brand: Yeah, I’m using the nebulize glue to find to get mycotoxins out of my brain. If you just go into PubMed and you just search okra toxin. Okra toxin is a really common mold toxin that we see. If you type in okra toxin cerebellum, you can read that okra toxin has an affinity meaning it likes it goes to that part of the brain, the cerebellum and so you can literally detox the brain. When people say detox the brain. It sounds like it’s like trendy or buzz worthy or something. But no, it’s real. You literally can detox the brain because that’s where okra toxin can can damage it can create damage in that part of the brain. So all right, well, let’s move on. I think we’ve talked about the sinuses all day,

Dr. Justin Marchegiani: I’ll do a video I’ll do a video of myself kind of dealing with the issues. So I’ll break On the nebulizer and kind of the solutions and, and we could talk about it and go over what those look like. That’s perfect. All right, good. I think those are powerful tips. And then obviously, we have low hanging fruit, which could be getting sick from food. So of course, we’re going to use things like activated charcoal, which is going to be a really good binder. We typically say take activated charcoal away from food and supplements, when you’re using it for like a detox protocol for mold or for bug killing. But if we’re eating questionable food, or we’re getting exposed to things like alcohol, we may want to actually take it with the alcohol or the questionable food. So you kind of have to just draw a line and say, Hey, is this an acute exposure issue? Or is this more part of the long term protocol? If it’s acute, and it’s food or alcohol or just you know, partying, then we’re going to take it with that food. 

Evan Brand: That’s a good idea. I mean, think about it. You’re going over to Uncle Jerry’s house. You know, everybody’s going to be drinking wine and cocktails and whatever. There’s going to be bread There’s going to be all kinds of food allergens and dairy and, and who knows what else cornbread and pumpkin pie. I don’t know what all you’re eating that’s not good for you. But, you know our clients report this every year they say hey, I’ve got off my diet on the holidays and now here it is January and they feel like crap, you know, so we’re trying to help prevent some of those calls.

Dr. Justin Marchegiani: Exactly. So I like that. Also bug killer so my line I have a product called gi clear 4 which I have found to be the best for me. And for most patients with food poisoning issues, it just works amazing. And it could be food poisoning from a bacteria like e.coli or Campylobacter or salmonella. It could be food poisoning from an infection. Right Giardia. Cryptosporidium H. pylori, maybe a parasite like blasto and this works really good at knocking it down. So I like my gi clear 4 which is very high in Golden seal, which is a really good bug killer, very high in berberine, which is great for SIBO. It’s also very high and all of which leaf which has antiviral properties, and burdock which is really Good for the lymph and the lymphatic system. So my gi clear 4 is good avid has some ones in his micro biome line that are similar to. So you know, we love a good bug killer in case we get exposed, and you can stay on a low dose of those preventatively to like I’ll do, I’ve got one that’s got all of leaf in there, which is just a good antifungal, and it’s been said to take antifungals while you’re detoxing mold, so for me, I’ve just been doing a little bit of a low dose of some antifungals just preventively. And the good thing is with something like olive leaf, that’s an antiviral as well. So you can have that’s the cool thing why we love herbs so much is because you can have as you mentioned, bugs is kind of a generality, bugs could be viruses, bacteria, parasites, you could have an herb that can be antimicrobial, antiviral, antifungal, all in one so we love these anytime of the year but especially if you’re around like you said potential bad food that who knows what if they didn’t cook the shrimp cocktail good enough, right? Or if it was all shrimp and and you got a exposed to something there. Yeah, so if you’re on vacation like let’s say Mexico or somewhere where the food may be a little bit different than what you’re normally used to people that go to Bali or Mexico or sometimes other countries, they’re exposed to things they’re not used to. So going on like a preventative dose, like one capsule with each meal, a lot of times can be super helpful. We may also do, I always recommend my patients flying with a full bottle of probiotics too, because that can really help with food poisoning as well. So we can do like one probiotic capsule every hour or two. And that can acutely address any food poisoning works phenomenally.

Evan Brand: So I like doing that to help with any food poisoning too. Beautiful and of course acid and enzymes deserve a mention up to just because you mentioned the travel. You know in theory if your stomach acid levels are good enough and you’ve got your gallbladder releasing store bile, you’re breaking down your fats good. Hopefully everything’s okay but it wouldn’t hurt to add in some extra enzymes and acids to hopefully neutralize any pathogens you could expose to

Dr. Justin Marchegiani: one Hundred percent. I think it’s vitally, vitally important. Probiotics clearing herbs we talked about gluta time we talked about silver, these are all really, really important modulating things, HCl enzymes, digestive support, kind of as needed, just so we can digest and break down our food. I think those are all very, very, very powerful things. Next, I think will be sleep support. So you could always do something like a sublingual, melatonin and just kind of do that. Once you get your schedule back on track, you can take it maybe at sunrise the next day. I’m sorry, you could do it at at nightfall. So as soon as the sun goes down, you can you know, as it gets dark, you can take it as it gets dark to kind of reset your cycle. And then when the sun comes up, you could do some kind of the caffeine with some light exposure and grounding can be very helpful to get your circadian rhythm back on track. You take a little bit of a caffeine or a mild stimulant. As the sun comes back up. You do a little bit of grounding your feet on grass or some kind of a stone while getting light exposure to the sunrise. That’s a great way to get your circadian rhythm restarted. And then at nighttime when the sun sets, do a little bit of melatonin, you know you can do anywhere between like a third of a milligram, very small those couple hundred micrograms to it sublingually and that can kind of get your circadian rhythm kind of back on cycle for your time zone again if you’re traveling to Mexico or something or the DR and then you’re only a time zone or two off, or even the same time zone not a big deal. You travel to Bali or maybe Hawaii or Europe then you’ll You know, you’re going off maybe 5678 hours that you may have to do a significant reset there.

Evan Brand: Yeah, good advice and of course light pollution at night always trying to address that a lot a lot of hotels luckily these days have pretty good blackout curtains and such but you know, we had several places where the outside light was still trying to sneak in so we would take extra blankets or towels or whatever else you got to do unplug alarm clocks, cover up lights, take out light bulbs, you know whatever you got to do to to cover it up. We had One room we had had a smoke detector that had a super bright green light and green light can suppress melatonin just like blue light can at night. So I just took a pair of swim trunks and threw them over the smoke detector, boom, we had darkness. So sometimes it’s tricky to get a nice dark room.

Dr. Justin Marchegiani: One thing I will travel with his electrical tape, black electrical tape and any lights like that, I will literally just take a piece tape, put over light,

Evan Brand: that’s easy, that’s great.

Dr. Justin Marchegiani: So just a little bit of tape. And then you can just tape up all the lights and then you want to make it black so blocks out the lights a little bit thicker, you know a little more opaque blocks the light out better. And I always call ahead and say hey, you know do you have dark shades or blackout shades? I think it’s really important. I stayed at one place that didn’t and I couldn’t believe it. I’m like, man, your sun goes up at seven o’clock you’re up at seven it’s like this, you know, that’s just you know, forget sleeping in. So I always try to call ahead and make sure I do have blackout shade options if not, you know get A blanket, tape it up against the wall. That’s your best bet. It’s kind of Yes. But yeah, go ahead.

Evan Brand: And also on the on the traveling thing too. We talked about air filtration. I travel with the water filter as well. I mean, you can buy bottled water for drinking, I’m talking about for bathing. So you know, a lot of places, a lot of cities really heavily chlorinate the water. And so of course, chlorine is like a natural antibiotic. So first of all, if you’re drinking water with chlorine in it, you’re killing your good bacteria and your microbiome. But regarding the skin, chlorine, I just doesn’t agree with my skin. It makes your hair nasty. It makes your skin nasty. It smells bad. It’s it’s toxic. It’s a neurotoxin. So I personally use the Berkey there’s other brands out there. Yeah, Berkey makes a really good shower filter. And I forgot to travel with my wrench. But luckily the shower head on the hotel was loose enough I could unloosen it. Put on the Berkey shower filter and boom, you got super pure water and for the little kids for my little girls. I don’t want them bathing and chlorine. So Guess what we do we just turn on the shower to fill up the bathtub and now you got a perfect chlorine free bath.

Dr. Justin Marchegiani: Exactly, that’s definitely a good option. Also, if I’m staying at a hotel in the states you know, I’ll just instacart for Amazon Prime now good filtered water, you know, couple bottles, couple dozen, maybe a dozen bottles of Pellegrino or or Voss or Fiji water, try to buy it in bulk or if there’s a whole foods nearby, just buy a couple of gallons and just leave them in the hotel room. So I have clean filtered water, you’re not paying an arm and a leg for the hotel price. But that way you can get some good clean water. Ideally, if you can get like a bunch of Pellegrino dropped off and glass that’s an awesome class may not work especially if you’re traveling a lot and you have young kids, you may have to do classes just for the convenience of it not breaking. So those are good options for you in the states try to use instacart or prime now or they can drop off within an hour to attend to be super helpful. And then I’ll also stay at a lot of places in the states that have a like a little kitchenette. So then I’ll just have a couple of dozen eggs dropped off maybe a pound or two again. again so then I have breakfast covered every single morning at least eggs or bacon and that way you’re set you could at least start the first meal out of the day pretty good and you can control the quality of it and I just try to make sure if I can there’s an instant Carter prime now service available where I could have it dropped off.

Evan Brand: Yeah, that’s what we did. We did we didn’t do the delivery. We just stopped at Whole Foods, but we did have a kitchenette. So we did bake and we did eggs. We bought some frozen fish. We had a freezer and we had an oven so we were able to bake some fish for a couple nights that was great. And we did find a couple good restaurants luckily they had some grass fed steaks and such but we tried to mix it up 5050 because you know you go on vacation you don’t want to be doing dishes three times a day either my wife’s like I’m doing dishes again what’s going on so like Okay, let’s go to a nice place get you a grass fed burger. And that was a good break from from dishes.

Dr. Justin Marchegiani: yeah, I actually was able to find so what I believe the country I like going to Mexico for vacation because number one you get, you know, nice little warm retreat, but it’s not far. It’s only just a couple hours from Austin. It’s easy nonstop flight virtually the same time zone. And when you get There, I found a resort The brand is charisma. And if you let them know I sent you over, but I found them because they were one of the only gourmet food brands meaning they grow all their food on site, super high quality. And they cater to food allergens. So really good quality food, lots of good restaurant options, all inclusive so you don’t pay anything extra. You get what you pay, and then you have unlimited access to the food. And then you can you know, you can get gluten free options. They really cater to the food allergen and you get better quality food. And it’s even you know, local locally raised right there on site.

Evan Brand: Yeah, I know you live like a king when you go down there. It is pretty cool.

Dr. Justin Marchegiani: Yeah, it’s nice because there’s a couple there’s a of like maybe 16 maybe 20 different hotels in the charisma brand, but it’s KARISMA just type in Karisma hotels, but they have a bunch of hotels couple doesn’t have a gore main line and that the formula This the food quality is five star so you have great quality food, organic, and you have lots of options and they cater to food allergens. That’s one of the best things about it.

Evan Brand: That’s beautiful. You know, I actually on my searches for hotels, I came across this website called pure rooms. PURE which was supposed to be this. It’s basically a company that works with different hotels, Marriott and whoever else and they basically put in water filters. They put air filters in the room, they use no fragrance, they take out any feathers for any allergens to like down comforters and such. The problem is every hotel I call they said oh no, we don’t do that anymore. Probably because nobody was ever booking the rooms and they didn’t want those rooms just sitting there wasted. So I called like three hotels and they’re like, Oh, yeah, we had the pure room, but we don’t have it anymore. So I don’t know if it’s somebody had to request in advance. But if somebody super sensitive, you know, you could look up your room and there’s basically a directory on the planet on the whole world where you can look at a hotel that would have a quote, pure room available for you to book.

Dr. Justin Marchegiani: Yeah, the nice thing is a lot of hotel rooms You know, they’re they’re getting better because people are more hypoallergenic people smoking is kind of a more taboo so they have non smoking rooms, I think just the big thing you can do is just try to request in advance, you know, not all the harsh cleaners or harsh smells, or just get a really good air filter like you have kind of drop it off, plug it in for a couple of hours, get the room kind of cleaned out, and then you’ll probably be good to go.

Evan Brand: Yep, that’s what we did. We put it on full blast, took a walk to the beach came back the room was was much better, still not optimal. I mean, I’d rather be at my house with my big ol nice air purifiers, but you know, you got to make the best of it.

Dr. Justin Marchegiani: Exactly. And then when I travel when I choose vacations, I want to come back on a vacation feeling good. So I don’t want to be eating crap the whole time. I want to be eating quality foods. When I come back. I’m not like bloated and inflamed and feeling like crap. So I want to food quality is a big deal for me. Number two is I don’t want to spend a day on the way there and a day on the way back traveling. So I try to choose places that I can go in a non stop and ideally be there within three to four hours on a non stop. I don’t like to get my sleeping all day. jacked up. So I don’t want to be up at like 3am leaving. So ideally, I try to find flights that I can leave at, you know, you know, get up at six or seven, get to the airport, leave at nine or 10 and get to where I want to be by, you know, three or four at the latest, you know, just because I don’t want to waste the day on each on each side and I want to feel relatively rested. So Mexico, Dr. Jamaica, you know, if if you’re like trying to go somewhere more tropical. Those are pretty good places because you get the tropical feel you can get an all inclusive access, and it’s not going to be too far or too expensive to get there.

Evan Brand: Yep, yep. Good advice.

Dr. Justin Marchegiani: Yeah, absolutely. So anything else on the travel side, you want to highlight? I mean, the only thing I could say is, if you know you’re going to be eating more crap, we talked about glutathione. I’m sorry, we talked about activated charcoal. And you can always want if you know you’re going to be having gorging yourself, you can always intermittent fast the next day to compensate. You can always do a little bit more movement before after whether it’s interval or resistance training just to deplete glycogen and to get your metabolism up on that way. The extra alcohol or sugar won’t hit yes hard. Those are all other good options that you can kind of add in.

Evan Brand: Yeah, I would just last thing just in general is some type of good adaptogenic herbs to help cope with the stress. So ashwagandha would be great. I know you love ashwagandha I love it too, but you could use it at night. You could use it during the day for stress, you could use it at night for sleep you could do you already mentioned the the the reishi mushroom for immune support, but that’s also kind of an adaptogen. Basically, you’ve got rhodiola which can help boost your energy. I took a mitochondrial support that I have. So that’s like a B vitamin combo that can be helpful because the stress of traveling burns up your bs B as in Bravo. So mitochondrial support can be helpful. Vitamin D, hopefully you’re going somewhere sunny. You don’t need vitamin D, but that’s also important for immune function. We talked about the enzyme piece, I would say liver support I did take some liver herbs to just some milk this old and some other basic stuff methionine tarin. I think That’s it. I mean, I’m sure we could riff on more but that’s that. Oh, yes. Oh, this is important. So anybody that has like any travel anxiety, which I don’t know if I have traveling anxiety, I just get stressed travels is stressful for me, especially with two kids and is the kid hungry and Okay, and the diaper and you know what I mean? So, what I took is just a blend of some calming herbs. So I took like some other war. I took some skullcap I took some Valerian some thenI, and just had a combo in tincture form. So we’re at the airport, you got 1000 people in front of you, you’re waiting to get past I just boom, boom, boom. Shoot a few squirts of some calming herbs in my system, and I was cool as a cucumber the entire time.

Dr. Justin Marchegiani: Exactly. Love it, man. Yes, smart. You know, try to do it the right way. Like you said, That’s why I try to do nonstops in and short flights. But if you’re going to Europe or anywhere else, that becomes a little bit tough. So like you mentioned, the adaptogens are helpful. That’s where definitely bringing the melatonin to be helpful. Some of the extra Bs, the B vitamins to help with stress, I think they’re going to be really helpful as well. Anything else you want to highlight or add today, Evan?

Evan Brand: I don’t think so I’ll just make a comment. You know, it’s so interesting. You see all these people that get on the plane, you can tell some people, they’re nervous and they order alcohol from the flight attendant, and they’re trying to drink alcohol to calm themselves down. That’s the worst thing you could do. The elevation of being on the plane causes dehydration. It’s like being on top of a mountain, the stress of it is depleting. So, I mean, if you need to calm yourself down, a glass of wine on the plane is not what you want. I’m not judging you. I’m just saying Would you rather have something awesome? Like, you take a few squirts of some passionflower and ashwagandha then your your nervous system is going to be calm. You’re not gonna have any crazy blood sugar swings on the plane, you’re not going to be dehydrating yourself. So I just, I just, I think in five to 10 years, maybe we’ll see more people like shooting adaptogens down their throat on the plane versus taking alcohol.

Dr. Justin Marchegiani: Exactly. I think number one, if you are going to consume alcohol, let’s say you got the upgraded seats and they cover a nice drink. Like when I go to Mexico, I think it was like I think I was I got the ability to upgrade to first class like 50 bucks. I’m like, heck yeah, you know, an extra foot a leg room. And so when I go to Mexico, I think I’m going to be going in February, I will be doing a glass of champagne on the flight because it’s complimentary. But what you do is number one, when you get to the airport and you have time, get a nice like, get a nice bottle of Pellegrino or something, hydrate before the flight where you know, so you have the good minerals in your system. And then if you’re going to drink then just have a nice, bringing a couple activated charcoal with you. So then you have that just kind of go back and forth. And if you are going to drink, just try to space out one drink one glass of mineral water, one drink one glass of mineral water. That way you don’t get too dehydrated, you get the extra minerals in the water, so you won’t be getting to deplete it. But I think that’s really a good important points.

Evan Brand: Perfect. Well, let’s wrap this thing up. If you do want to reach out clinically, we work with these gut issues that we’re talking about detox problems. You know what we do? We love helping people get to the root cause of their problems. You know, we were used to someone being through 510 15 practitioners before they get to Dr. J. Or me And we kind of like being I’ll speak for Justin as well, we kind of like being in that position because it allows us to show them what we do differently. And oh, here’s why you didn’t get better. It’s because you didn’t you didn’t do this or you didn’t look in that ballpark or you did it in the wrong order. So we love and some, sometimes it comes with the territory of our jobs to be in the in the cleanup crew category. We’re cleaning up somebody else’s mess. And that’s fun. I love that and we’re both very grateful to be able to serve you well. So if you want to reach out to Justin clinically, please do so his website is Justin health. My website, And thank you for listening. We appreciate it.

Dr. Justin Marchegiani: Excellent. I think next week is was next year, next week, next month in New Year’s Eve. Yep. So I think I’ll be here next Monday as well. So I’m excited to chat with you again. How about you Evan? Will you be here?

Evan Brand: I’ll be here. I ain’t going anywhere.

Dr. Justin Marchegiani: All right. Excellent. I love it. You’re back from your vacation. You’re supposed to be refreshed. So yes. Excellent. All right now great chatting with you put it thanks for all the information on the product. We talked about or recommended. We’ll put them in the references links below. Evan, great chat with you have a phenomenal week. Will you take care bye bye. Thank you, everyone. Bye


Xlear Rescue Nasal Spray with Xylitol

Austin Air Health Mate Junior Plus

Audio Podcast:


The Thyroid, Adrenal and Microbiome Connection | Podcast #255

Together with Evan Brand, Dr. Justin talks about the adrenal, thyroid, gut, microbiome, brain connection and a lot more. Go through this podcast to discover more about functional medicine world. Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

4:13 Potential probiotics to treat thyroid nodule

9:06 Microbiota modulate anxiety like behavior

15:02 Stress in gut

20:16 Chemicals in water

23:10 Eating organic



Dr. Justin Marchegiani: Getting ready to go live now go get it live this week. And we are live. It’s Dr. J here with Evan brand. Evan, how are you doing today? Man? I know in the pre show. We’re gonna we’re going deep, deep into the adrenal thyroid gut microbiome connection. How are we doing, man? 

Evan Brand: I’m doing really good. Yeah, this is trippy. You know, people talk about the gut brain connection. But when you actually look into the papers on this, you actually just found a paper that was from just a few months ago, that will have to dive into on gut brain, adrenal connection, thyroid cancer, all being tied into the gut. So where do you want to? Where do you want to start?

Dr. Justin Marchegiani: Yeah, so this one article, I just want to read the summary of his articles. I think this really shows you the connection of the microbiome with the thyroid and of course, we have some scientific articles looking at the microbiome with the HPA access and connecting to the adrenal, so this is really, really powerful. I just thought this one conclusion here, and I really wanted to highlight it because I just think medicine is just really going in a totally different direction. So the title of this article here, I’ll read it all for you all here is dis bios of the gut microbiome is associated with thyroid cancer and thyroid nodules. And there are correlated with thyroid function. And essentially, we know that autoimmunity which is the number one cause of thyroid issues with almost all people, right, that is a major association with cancer and with nodules, of course, the major cause of thyroid nodules are going to be autoimmunity. But the conclusion of this study was interesting they found our results indicate that both thyroid cancer and thyroid nodules are associated with the composition of the gut microbiome. These results may further support a clinical diagnosis to a great extent, and helping in developing potential probiotics to facilitate the tree Men have thyroid cancer and nodules. So conventional medicine in the Journal of endocrinology starting to come to the conclusion that, hey, we need to have probiotics to treat thyroid cancer and thyroid nodules. That’s pretty amazing.

Evan Brand: That’s a trip trip. Well, I’ve got another paper I was looking at here that was about babies. So let me read this one because this is pretty interesting and, and kind of up the same vein here that this was looking at 78 infants who were premature and were in the queue. And it was found that the infants that had despite AOSIS, which I just call an abnormal gut microbiome. They had more gut issues, even at age four of age, they followed these kids for four years. And if their gut was screwed from day one, even four years later, they still had gut issues. So not related to thyroid but just crazy how much the stress of the mom The diet of the mom the microbiome of the mom, if the mom doesn’t have enough good bacteria, not giving good bacteria to baby, this is crazy. I don’t want to get too off topic from from thyroid to babies, but there’s countless papers coming out on even there was another one I looked at two, which was about sun exposure, right. And the sun exposure paper was looking at people getting UVB as in Bob UVB light exposure. And they had significant changes with their gut microbiome but it only worked in the patients that were deficient in vitamin D. So there’s this you know, our mutual friend jack crews, he’s always talking about Sunlight, sunlight, sunlight, everybody gets sunrise get your skin exposed to the sun. It turns out Yes, that is totally true because in various studies, living in higher altitudes means there’s a higher risk of developing inflammatory bowel disease and Ms because at a higher latitude and higher altitude both you get less UV light. So now There’s this gut flora, sunlight link as well, but it only was in vitamin D insufficient patients. If the vitamin D levels were normal, the sunshine didn’t do as much to boost the gut bacteria.

Dr. Justin Marchegiani: Interesting, very good. So I want to just kind of connect the dots here with some of the more valuable Intel. So in the study that I just looked at, where they’re talking about potential probiotics to treat thyroid nodule, and of course thyroid function issues and thyroid cancer, the couple of things to highlight is what does that mean? So despite doses typically means a higher amount of bad bacteria in relationship to good bacteria. Now in this one study, just kind of giving people to take home is the bad bacteria they were looking at that they were looking at they were higher in these cancer patients was the streptococcus and the nice Syria bacteria, and the beneficial bacteria was the lactobacillus and they also looked at the beautiful record bonus and beautiful components. I think it’s just bacteria that helps make beautiful Beauty rate is the same fat that’s in butter. Okay, so eating healthy butter and things that help improve beauty rate bacteria could be very beneficial. Also, anything that’s going to be fermented is going to give you healthy levels of lactobacillus and support puter rate is great. So those are the big bacteria that we’re looking. So I mean, these studies are limited because you’re not looking at a whole suite of bacteria, right, or a whole suite of positive probiotics. So these studies are still a little bit myopic, and their focus, but I think it still gives us a little bit of insight that probiotics, beneficial bacteria important and some of the despotic bacteria can have negative implications even affecting your immune system and even cancer. So I think it’s good to keep that in the back of our head. So when we’re seeing patients, we’re recommending comprehensive gut testing, that’s DNA based, it’s looking at all kinds of normal Flora imbalances, despotic balances, we’re measuring it to, you know, the umpteenth degree because the DNA testing is about two to 3000 times more sensitive than your typical stool testing, and then we’re also looking at infections because the bigger thing here I think is we could have an H. pylori issue or a fungal overgrowth, or we could have a, a major parasitic infection that could be thrown off the bacteria too. So sometimes the bacterial issue isn’t necessarily the root cause. It’s an effect of something deeper in the gut. That’s kind of going wrong. And then also, we have to look at the fact that gut stressing gut inflammation can throw off digestion and when our digestion is poor, we’re not ionizing minerals. We’re not breaking down our Selenium and zinc and magnesium. We’re not breaking down protein as well. We’re not absorbing all the the hormonal building blocks like cholesterol and fatty acids and protein and fats to make our hormones and our neurotransmitters. So you can see this isn’t just an isolated issue, it spirals off into other systems not working well. That’s why you need some more the clinical picture clinical, I’m for this like me and you to dive in deep and kind of spiral off the intimate connection. And how and how and why this is a big deal.

Evan Brand: Well, I love that this paper exists because between you and I both we’ve put a combined 15 plus years of education and content about gut and how important it is and how it affects every other body system. But you still have people that go to their conventional doctor and they’ll say, hey, my guy and work with Dr. Justin told me that my gut is affecting the thyroid. And the endocrinologist says, No, it doesn’t know your hormone levels are just low. We’re going to bump up your your Synthroid, we’re going to give you extra t three and supplemental form and blah, blah, blah, and they never bring up the gut. Well, now here’s the proof in the pudding. Here’s the paper that proves what we’ve been saying the whole time. So it’s good. I like I didn’t need the validation, but I guess for maybe for our ego sake a little bit when you get good results with people. And we’ve seen countless time and time again that the thyroid antibodies and Hashimoto is go down when we fix the gut. I’ve always loved seeing that. But now we have the proof to be able to show why this is working.

Dr. Justin Marchegiani: 100% and I saw a patient just from a few years back, her antibodies were well over 2000 2000 regarding feral globulin and they were around 30. Now, so I mean, you’re looking at a 99% reduction with thyroid antibodies. And I’ve seen that quite frequently, and people listening and may not be practical to get your antibodies down, even below the reference range or even negative or to zero. That may not happen. But if we can have a 50 to 90% reduction regarding those antibodies, that’s going to be huge.

Evan Brand: Let’s Let’s move on. Let’s go into this other paper that you had sent me this was the one that was from frontiers and cellular and infection. microbiology. This was a 2017 paper. It was called microbiota modulate anxiety like behavior and endurance abnormalities and hypothalamic pituitary adrenal axis. Let’s go into this because this is another frickin awesome paper that proves what we’ve seen with regarding mood and the whole adrenal connection type into the gut. 

Dr. Justin Marchegiani: 100%. So if we go into the what’s that again? 

Evan Brand: This is the one I’ll I’ll put it back in the chat for you here. This is the pub man one, go check your chat I just put it in your chat on on zoom. This is the one that’s called microbiota modulate anxiety like behavior. And so I’m going to go into Yes, kind of the bottom section of this, where it’s showing all the pictures here about the connection between you’ve got your cortical, yes, hormone, your AC TH you’ve got the metabolic effect picture here. And what we’re finding is the microbiome, the gut, your microbes, your intestinal microbes, they are changing this whole brain gut access activity, and all of your gut microbes are responsible for your dopa mean, your Gabba, you’ve got histamine, you’ve got acetylcholine And regulating the function of the CNS, which is your central nervous system and the stability of the HPA axis. This is the crazy part to me, this last part of the sentence that the intestinal microbes regulate the stability of the HPA axis. Because when we talk about the kind of this brain adrenal connection, we just talked about, like adaptogenic herbs and you know, I meditate and and deep breathing and extra Asheville, ganda and all that and maybe you need some l theanine, which is all cool. But if you’re just doing that you’re missing the boat, you’re missing the fact that the gut is going to overpower any effort on your brain. It’s like, Oh, I’m going to go do yoga to calm my nervous system. You can’t if your gut microbes are screwed.

Dr. Justin Marchegiani: Exactly. I want to highlight one sentence in this study conclusion. I think it’s vitally important. They say here imbalances of the HPA access can’t cause by intestinal microbes. So now this study is kind of submitting to the fact that the microbes are calling HPA access imbalances could affect the neuro endocrine system in the brain. That’s the brain talking to the hormonal system primarily through the adrenal and the sympathetic nervous system and the parasympathetic result in anxiety like behavior. And the study suggests that intervention into intestinal micro Flora may provide a new approach for treating stress like diseases that is profound. They’re talking about altering the microbiome typically. And that’s going to be done in two ways. It’s going to be done by killing or knocking down this biotic bad bacteria or supporting beneficial good bacteria. Those are the two modulatory ways to do it. So that’s amazing. The fact that conventional research at no one even talks about this on the conventional medical side, partly because it’s about a 20 to 30 year lag between stuff and the literature making its way into conventional medicine and there needs to be a profit motive. So if a big pharma company cannot patent what’s happening here, and we probably won’t see this be applied, because there’s gotta be a reason to spend billions of dollars in research and get patents. And if we can’t patent it, what are you going to do?

Evan Brand: Yeah, so like the $30 bottle of probiotics that we sell after we do some type of a gut killing protocol, I mean, 30 bucks, is it your profit margins, not going to be like some of these cancer drugs, for example, they’re like 1000 to 10,000% markup, you know, you’ll have like, one vial of chemotherapy, that’s 10,000 bucks.

Dr. Justin Marchegiani: Yeah. And it’s not just a, it’s not just the the money you make on it, it’s the ability to guarantee that you’re the only one that can produce it. So if you get the patent, that you’re the only one that can produce it, then you can artificially make the price higher, right. So that’s kind of how it works. It’s not that there’s not a natural profit, you know, like a 50% markup or something like in a lot of stores that you see is going to be thousands of percent markup, and it’s going to be artificial, did a patent law.

Evan Brand: Oh, that makes sense. Yeah, you’re talking rather than 20 companies all making the same thing and charging 100 bucks if you’re the only soul guy, then you’re allowed to charge 10,000.

Dr. Justin Marchegiani: Yeah, you can charge a lot of money for it. Yeah, that’s how it works. That’s how you saw that with the, the epi pen when the patents went out. Only one company had it and they jacked it up. And that’s kind of that’s how it happens. So the more we can use things that are natural, that can’t be patented, you know, then you have a little bit more market force keeping the prices down. So that’s nice. So interesting. In this study, they also talked about however, the precise mechanism of action and how intestinal micro Flora means unclear. So it’s really interesting they have there’s some unknown pathogenic mechanisms I think with a lot of the the infections causing problems, my gas, all right, my into intuition really comes at it from the perspective of intestinal permeability. I think the intestinal permeability aspect is a big one. I also think a lot of the good bacteria has a modular Tory effect on your immune system, because we know your immune system is in the gut. So if your immune system is hyper regulate or hyper stimulated, that can do a lot of different things from increasing gut permeability, to just sucking up a lot of resources for energy. And I think it also has a negative impact on your mitochondrial function as well. And then I think the low hanging fruit is you may not be digesting, absorbing and assimilating a lot of the key nutrients in your diet, which go to make other systems work like your mitochondria, like your thyroid, like your adrenal, is we not getting enough selenium, we may have thyroid issues not getting enough. Magnesium, we may have issue with our mitochondria. So we need a lot of these nutrients. And if we have stress or interplay with the HPA axis and our gut, there could be some absorption issues for sure.

Evan Brand: We should almost just title this podcast which we already came up with a better title that you’re that you’re seeing or you already clicked on to download this, which was like the microbiome adrenal thyroid link, but really, we should call it yoga ain’t gonna fix you. gut. I mean, that’s basically the summary here.

Dr. Justin Marchegiani: Right. And again, there’s a lot of data on this where the stress in the gut and stress in the brain is bi directional. In other words, Stretton the stress in the gut can create brain stress, but stress in the brain can create gut stress. And we know this because high levels of cortisol stress in the brain that makes a CTH adrenal cortical tropic releasing hormone that stimulates the adrenal to make cortisol that can create gut permeability at high levels, it can break down the gut barrier, and we know stress in the gut through number one is gluten is a big one can easily create gut permeability, which can then also create gut stress. So these are important things. Quick Study I want to pull up here. I did not show it to you but this is called dietary gluten induced dysbiosis can create issues with the tight junctions. And that’s the summary of the title. The title is really convoluted, but

Evan Brand: I want to have that link from book market myself. 

Dr. Justin Marchegiani: Yeah, I’ll send this to you right now. So you have it. But this is fascinating. And basically they’re talking about gluten having a major impact on the gut bacteria and creating this bio system. And we know with this by osmosis, that can affect the whole neuro endocrine HPA axis cascade of things. And they talked about dietary gluten had effects on the streptococcus family, the lactobacillus family, the Koryo bacteria family, really, really, really interesting and how it affects different things. It Down regulated, the guts, absorption and a lot of different ways created inflammation. So there’s a lot of different potential cascades that happen when gluten comes into the equation. So the low hanging fruit that we talked about is kind of getting patients on a paleo template which is a grain free, grain free, dairy free legume free template. And then potentially even moving towards a paleo template where we’re going grain free, legume free dairy free, no nuts, seeds, nitrates and eggs.

Evan Brand: Yeah, you may have the autoimmune. So here’s the point that we’re trying to make is that the people who say, Oh, I eat gluten and I feel fine. It’s not about whether you feel fine. It’s about that internal biochemistry that’s changing. It’s about those microbes that are changing. Also, in that study that you just sent me here. It was talking about Prevotella being affected too. We know there’s a huge link between Prevotella and joint pain. We did a whole podcast on joint pain, you know, functional medicine. And so it’s not that like, Hey, you have to get a rash or you have to break out an acne after you eat gluten. That’s not it’s a lot more subtle, but the subtle changes over time, change the whole system.

Dr. Justin Marchegiani: As a lot of people out there that I hear I won’t mention their names but their podcasts out there and say, Hey, you know, you can have gluten if you haven’t, you don’t have any symptoms. You know, you’re fine. The problem is the inflammation that’s happening here. may not create a symptom, there may be a delay in the symptoms that occur. And that that’s kind of the myopic level of thinking. You can’t just you can’t go to that conclusion, well, if you don’t have symptoms, you’re fine. In this one study, they’re looking at inflammation associated with the micro RNA. So they’re looking at inflammation at the RNA level. I mean, that is a very myopic level, very, very microscopic level, I should say. And in this study, they had some people on a gluten free diet and some eating gluten. And they saw on the gluten diet, they saw this increase in inflammation at the micro RNA level, which is pretty profound. So it may take time to manifest into actual symptoms. And we know there’s data on the fact that there are people that even if they aren’t celiac, or even really gluten sensitive symptomatic Lee, they still saw permeability with their gut when exposed to gluten. So kind of my general recommendation is try to be grain free all the time, especially if you have an autoimmune condition. And if you’re going to cheat, try to choose gluten free cheat, if you can. Now, if you don’t have a known autoimmunity, then maybe you choose a little bit of gluten here or there but be very careful with it. Try to do things like extra enzymes, extra enzymes with DPP for maybe some extra activated charcoal include a bio and to kind of deal with the stress and the inflammation associated with that you can also add in some extra glutamine and things help with the gut lining. So these are some ways that we can mitigate it. So I kind of I tear things a known autoimmunity, no gluten ever, and if you’re going to cheat, try to make sure it’s gluten free. If you’re relatively healthy and no autoimmunity, then maybe you cheat a little bit with gluten but try to make it a special occasion holidays, birthday, etc. and then try to use things to blunt the negative consequences that may occur.

Evan Brand: Yeah, well said people aren’t even aware of that. We have some little cheats in our pocket, especially that will give to people around the holiday season, different enzyme formulations that can actually sort of break up or reduce the effect of some of those food allergens. Your dairy, your corn, your egg or soy, you know, you can use enzymes to help break those apart. But we don’t want people to get hooked on those or use that as a long term solution, because then you’re still cheating and it’s not going to be reducing the the impact 100% it’s just going to blunt it, as you said. 

Dr. Justin Marchegiani: Exactly. And one thing I wanted to highlight, I saw this article come across my desk too. It’s a compound called Tributyltin, is in the chemical paint that they paint on the underside of the hall of the boats, and this compounds getting in the water, and they’re finding that this compounds actually an obese engine, and it negatively impacts the gut microbiome and then you’re getting exposed to this in the waters. So I think this is really important, why we need to be filtering our water because it’s possible that these compounds may not be filtered out with conventional filtration processes. And this compounds Aaron obesogenic and they affect your microbiome. So another great reason why you should head over our sites get a good high quality Water Filter that we personally use or slash water. I’ll put the link in the description. Waters a big component is a lot of chemicals and toxins and tributyltin and it’s just one compound that could negatively impact your gut microbiome.

Evan Brand: Oh man, that’s amazing. Well, there’s countless like that I just got the Environmental Working Groups report on local Kentucky’s tap water. And you know, people say oh, we got voted the best tap water in the US because we’ve got a lot of limestone here naturally that kind of filters out our water. It was still garbage man. There was still tons of flame retardant chemicals that PFOA which is like the Teflon nonstick chemicals, foams, heavy metals, pesticides and herbicides. I mean, we had countless pollutants in our tap water here, even though it was voted best and it does taste good. But you might you’re not going to taste these part per million chemicals that like you said can be an obese adyen or disrupt hormones. So yes, drinking tap water can make you fat and sick. Absolutely.

Dr. Justin Marchegiani: Of course and then the number One thing you can do, this is a no brainer. Most of our audience and listeners know this is avoid glyphosate. So you really want to eat 100% organic because glyphosate, many, many studies are shown to affect the microbiome couple of rat studies, looked at different rats and microbiome and saw significant, you know, impact on the microbiome of these rats when exposed to glyphosate. So you really just got to be careful, make sure you eat organic as glyphosate, which is the major pesticide Roundup. And again, one of the studies I have up here now 13 weeks study, guess what bacteria were knocked down with Roundup. I mean, I’m going to guess all of them but probably lactobacillus. lactobacillus was the major one. It was reduced in the roundup study. And we know that the thyroid cancer study showed what that the cancer group had lower amounts of lactobacillus and then when we improved it, you know, we saw an improvement in the cancer. So we know lactobacillus is beneficial and glyphosate, roundup same name is going to negatively impact that.

Evan Brand: That’s a trip well, so people say, Oh, I haven’t done antibiotics doesn’t matter. You did an antibiotic and the glyphosate.

Dr. Justin Marchegiani: Yep, exactly. So you really want to be careful. This is another reason why you want to eat organic. There’s two reasons right? Number one, you’re avoiding toxicity, which is going to affect your microbiome and your immune system. Number two, increased nutrient density. Typically, organic farming will have higher level of nutrient density because the soil microbiome will be more healthy and the microbiome and the topsoil produce help the plants produce more nutrition. So we’re nutrition on one side, less toxic than the other side. And even if, let’s say you don’t buy what I’m saying about nutrition, just the fact that you’re getting less toxins, right? Because for it to be organic, USDA Organic, it has to have no pesticides in that soil for three years. You are definitely getting less toxins, for sure.

Evan Brand: Yep. Well, this has been fun. I mean, we could do Part 2 3 4 5 6 7 8 9 10 on this because this is like one of my favorite favorite things ever. So we’ll be back to talk more about I’ve got so so I’m just giving you I’ve been told you this, but this is what we’re going to cover. Next we need to cover the gut microbiome in the issue with pans, which is the pediatric acute onset neuro psychiatric syndrome and kids. I just sent you a paper on this one. Let’s Let’s hit this next time though, because it’s a whole nother can of worms, but it’s about all these children that are having behavioral issues and anxiety and different problems. And it’s related to certain species in the gut. And if you can shift the gut out of this pro inflammatory state, you can calm the brain down. I mean, we basically already hit on that but it’s a little different for kids and I’ve seen it personally and clinically, you have to So I do want to get into this and also, there’s talk about the specific bacteria this or ODR bacteria and the link to autism. And alzheimers. So Wow, this is I mean, it goes deep.

Dr. Justin Marchegiani: I love it totally, what I’ll do is I’ll put all the links of all the studies that we talked about today in the description so you guys can go take a look at it so you can see it for yourself. It’s amazing. Your conventional medical doctors aren’t going to know about this stuff. And it’s because of the 23rd 20 to 30 year gap between the literature and going into effect in the curriculum. And also there’s just has to have a profit incentive for the big pharma if if they can’t patent it, then you’re not really going to use it as a modality. And guess what, as functional medicine docs, we take that up and we put that in our metabolic toolbox. TV’s healing get better. So I love it. Is there anything else you want to highlight today? Evan? 

Evan Brand: We’re going to be looking into your gut if you’re working with us, so if you’re like, Okay, what do I do? How do I investigate this? How do I fix it? I mean, we live and breathe and look at labs all day every day. So we’d be happy to run some panels on you and take a look at your gut and see how is your thyroid function affected by your gut? I guarantee it is how much is it affected. I don’t don’t know yet, but we can run some labs and figure it out. So if you do want to reach out clinically, you can do so at Justin’s website, which is he works with people all around the world. So do I, my website is, and we don’t care who you work with as long as you get better. So please reach out if you need help. That’s what we’re here for. Don’t wait till you’re super miserable. We got tons of people that like buy supplements and listen to podcasts and listen to summits and they buy 50 to 100 supplements and they don’t know what the heck they’re doing. You’re spending a lot more money in wasting time and maybe getting sicker by doing that. So it’d be much better to have somebody that can help walk you through the process rather than you buying this probiotic and it didn’t work and then you bought that gut healing supplement and didn’t work and then you bought this detox supplement, you felt like crap, Okay, stop doing that. You know, let us help you through what we found to work clinically.

Dr. Justin Marchegiani: 100% also we can get a window into the HPA access as well using cortisol rhythm testing. So we’ll measure your cortisol which is your major stress hormone. That’s the hormone that Made by or that stimulated by ACTA, that’s that brain chemical. That’s the neuroendocrine connection, the brain, the ACTH, the cortisol, we can look at that rhythm. And that gives us a pretty good interplay into HPA access functioning, because the data says that, you know, as that cortisol starts to get this regulator rhythmically, that’s a big sign that the HPA access is out of balance. And so we can use specific herbs, we can use protocols, we can work on fixing the microbiome, we can look at getting rid of some of the chemicals like we talked about, we only mentioned to today, the cyberbullying and the glyphosate, mold, and others toxins and metals could be another factor as well. That’s another podcast of the day. So there’s a big is a big net that we’re kind of looking into and trying to connect everything here because everything’s intimately connected. And I hope you guys are enjoying the Intel. If you’re feeling overwhelmed, just feel free to reach out to us we can help break it down. The big connection here today is stress, brain stress, HPA access. That’s the communication all feedback loop brain to the adrenal brain to the thyroid. Think of that as the thermostat to the heater thermostat to the air condition, right? Imagine you having that thermostat not talking appropriately to the heater when you want it to get hot, or the air conditioner when you want it to get cool. And that’s a big big connection. So when we talk brain stress, or HPA access, pretend like your thermostat in your house is not working or probably that’s kind of the equivalent here.

Evan Brand: Makes sense. Makes sense. Well said.

Dr. Justin Marchegiani: All right. Well, if you guys enjoyed it, give us a thumbs up give us hit the bell as well. So you subscribe. We appreciate great reviews, for reviews. And let us know your comments down below things that have helped you things that have hurt you in regards to the HPA access and your gut microbiome. We appreciate it. Evan, it was great chatting today man you have a phenomenal day. 

Evan Brand: Yeah likewise you too see you. Take care. Bye bye.


Audio Podcast:

Mood Imbalances and their Root Causes | Podcast #250

Depression, being the #1 cause of disability in the US, has tons of other mood issues that come along with it. Some psychiatrists are not telling what are the things that caused us mood issues,and what should we do to lessen it.

For this podcast, Dr. Justin and Evan Brand talks about root causes to mood issues.  Also, learn through this podcast the importance of blood sugar maintenance, sleep, diet, and a lot more.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover: 

01:15 Moods and Diet

03:40 Blood Sugar

09:00 Sleep

12:20 Chemicals in Food

14:40 Progesterone and Estrogen


Evan Brand: I’m doing very well. This is an exciting topic because depression is the number one leading cause of disability in the US and there’s a ton of other mood issues that come along with depression and your psychiatrist is not telling you that you need to detox heavy metals and get infections out of your gut and stop eating pesticides and all the other things that are causing a mood issues. They just give you a drug to treat it and give you a Band-Aid which has save lives but it’s not the root cause so we always love root cause. 

Dr. Justin Marchegiani: 100% So let’s talk about some root cause foundational mood stuff first and we kind of have the Nuance nitty-gritty stuff and then we have the foundational stuff. So the first thing is just your diet, right? We need a nutrient dense anti-inflammatory low toxin dietary template and I I like to talk about diets me template. It provides a lot more flexibility and then we have a framework premise and why we recommend the things that we recommend part of it is foods that are evolutionarily appropriate Foods. We had enough time to adapt to eat, food that are going to be low in toxins, whether it’s anti-nutrients are oxalates are five dates or natural plant Oxalis plants have claws and feet to run and Fun Run and fight so they have berries toxins, right? So we want to make sure were using cooking methods and avoiding toxic plants, especially the more got issues we have and that anti-inflammatory, right? We know foods have the ability to move us to an anti-inflammatory environment good healthy, omega-3 fatty acids good healthy saturated fats of the more process refined omega-6 that are more fragile and they can move it move us more in that Pro in from inflammatory State and then of course the nutrient density foods are going to be super nutrient dense B vitamins minerals. Obviously the food quality is now a big deal because you can have the same kind of meat on on your plate. Looks totally different under a microscope because of the hormones because of the feeding practices cuz the medications and the and the drugs given to the animal while they were having their life and growing so to speak. So we have to look at nutrient density anti-inflammatory status and hormones and toxins are the big things off the bat. 

Evan Brand: I’m glad you about this before but we could just bring it up briefly which studies done on prisoners and when they were giving Omega-3 supplements basically fish oil supplements, they had less violence and less just crazy behavior overall and there’s been some like Psychiatry studies looking at just overall like homicidal rage and suicidal thoughts and those things in there directly correlated with a deficiency of omega-3. Fatty acids 

Dr. Justin Marchegiani: Omega-3 is really important. Also blood sugar stability. There’s also data on the fact that’s Information I should say. Are you able to see me hear the screen? 

Evan Brand: Yeah, I see you perfectly.

Dr. Justin Marchegiani: Good excellence. All right, so there’s information showing that. Mood issues anxiety and depression is a result of inflammation in the brain. And we also know that anytime low blood sugar environment can happen right refined carbohydrates blood sugar Spike followed by a drop that’s called reactive hypoglycemia. Those kind of those kind of situations are going to create mood issues and this data on the fact that a lot of violent crimes are committed in a hypoglycemic environment and some of the data on that is because of the fact that low blood sugar and are making shutdown activation of the frontal cortex in the frontal cortex is the part of the brain that’s going to predict the outcome of an action so it can say Hey, you know that person that just pissed you off. I want to go hit him or go call him out. And then that frontal cortex has that like 20 milliseconds of hey, you know, if you do that you may get arrested and it can dampen the impulse so to speak so the more you have good activation of that frontal cortex through reducing inflammation. And then also maintaining good blood sugar and part of that as we become more fat burners and that fat burning environment put logs on our metabolic fire was future blood sugar from going up and down and then avoiding a lot of a refined carbohydrate which tends to make our blood sugar go up and down as well. 

Evan Brand: Well, this is part of the reason people make bad decisions when they go out to a bar into a club and they drink alcohol and go home with somebody that they don’t want to partial partially due to what is alcohol. I mean, it’s basically correct liquid. It’s basically liquid sugar. It’s going to crank up the blood sugar but it’s also going to crank up serotonin and then the serotonin is going to just flat line and when you run out of Serotonin, you can’t make decisions that are smart. And so if you are somebody who is struggling with mood issues alcohol needs to be out of the picture completely for multiple reasons that we just met-

Dr. Justin Marchegiani: Blood sugar or I should alcohol actually lowers your blood sugar can create a hypoglycemic and where I might just go take a for instance a shot of vodka and just test your blood sugar your blood sugar. Drop restaurants do this on purpose because they know if they can get you some refined carbohydrates and pretzels and some bread and then they can get you some alcohol pretty fast. They’re going to cause a reactive hypoglycemia environments and you’re going to be ordering more food and getting more carbohydrates may be ordering a bigger desert whether or not they understand the biochemistry of it all they understand that if they do these kind of things in the beginning of the meal they can create a larger bill for you at the end of the meal.

Evan Brand: Should have clarified like margaritas and things that have like agave syrup and all the sugary stuff mixed with the alcohol. That’s when your blood sugar is going to go crazy, but I haven’t tested the Vodka by itself. That would be cool to see on a glucose monitor. 

Dr. Justin Marchegiani: Exactly yup 100% you can really create some significant significant issues of significant stressor 100%. 

Evan Brand: So we could spend time and talk about this isn’t for today. But I mean, there’s like a traumas for example, you know any trauma that’s left over in your body, you know physical mental abuse or anything like that yet. You must address promise. I don’t want somebody listening and thinking if they just perfect their diet and get rid of alcohol. Their mood issues will go way there could be super deep traumatic issues that need to be addressed but no we were trying to focus on more like the biochemistry aspect the blood sugar affect adrenals hormones thyroid got those things. 

Dr. Justin Marchegiani: 100% Yeah. I totally totally get that for sure. So in general we have the inflammation components to so of course gluten to be a big one there the main mechanism how gluten is in a create more mood issue is going to be through inflammation and it can create gut permeability and that gut permeability can allow various inflammatory cytokines and Undigested food particles to get in the bloodstream that can create more of an inflammatory response and then create leaky brain as well. And then a lot of these inflammatory compounds whether it’s lipopolysaccharides or just inflammatory foods that are unprocessed that you have that immune response these particular can get into the brain but through the astrocytes which of the blood-brain barrier and then that can activate our glial cells in our brain and that can create more cognitive issues more information in the brain and some of the newer families of antidepressants that are coming out very soon. These medications are actually working more on inflammation in the brain problem is like any medication is going to be at have inherent side effects just because of the fact that Any medication does when you block and inhibit various enzymatic Pathways other things happen as a result, like the old vioxx days with these cox-2 inhibitor medications the cox-2 enzyme the cyclooxygenase to enzyme that was being blocked by some of these medications like vioxx. Well, those enzymes also have beneficial effects on recovering liver heart and gut tissue to then you had a lot more stroke and cardiovascular incidences. When you were on this medication. Do you know they worked at enzyme and other important roles outside of just blocking paint. 

Evan Brand: Where they pulled from the shelves. I mean, that’s like long gone, isn’t it? Maybe I should look it up. 

Dr. Justin Marchegiani: Yeah that was pulled like 10 years ago. I make more cat a massive lawsuit around that I think it was on record of killing 60,000 people. Yeah. Yeah. I know really sad but we are going to do you know?

Evan Brand: All right. So let’s talk about the Sleep aspect like for example 3rd shift workers much much higher incidence it personally when you’re working a third shift. You’re messing up your circadian rhythm your serotonin in your dopamine your melatonin your cortisol all these hormones and neurotransmitters that can act as both neurotransmitters and hormones. They all have a circadian rhythm. And if you’re not going to bed with the sun and getting up with the sun, you’re probably not going to be optimally happy now. There may be a few people listening. So I work 3rd Shift for 20 years and Im as happy as a lark. Okay, Mike, maybe you’re unique but as a general human rule going against the sun is not going to result in Good Moods. It’s that simple.

Dr. Justin Marchegiani: Yep, 100% shiftworks a big one. We know that I can definitely Cradle by The Moody she’s partly because we are hardwired to kind of be on a natural circadian rhythm Right light stimulates cortisol cortisol stimulates, you know alertness and and being awake and then that cortisol drop throughout the day and a Miralax at night and darkness stimulates melatonin antioxidant information helps you recover. So yeah, that’s a really important step into this. Equation for sure. So they sleep component, the food the nutrient density component think it’s really big. Lets go to the next low hanging fruit– digestion. Okay, great. Were eating a really good diet. But now we got to actually break down those nutrients those nutrients so we gotta make sure what you and our food up. Well, we got to make sure we have enough acid and enzymes to break down those amino acids. Those fatty acids those cholesterol compounds cuz they are building blocks for a brain is cholesterol and saturated fats are hormones are building blocks from cholesterol as well. And then our brain amino brain chemicals. They’re all going to come from amino acids, which come from protein. So all of our brain chemicals norepinephrine dopamine Gaba serotonin serotonin than Converse the Melatonin which is our sleep hormone and our antioxidant for the brain, they all come from protein. So we really have poor digestion and their studies actually on H. Pylori for instance cant create mood issues. And what’s the major mechanism? My opinion, the mechanism is the fact that you have poor digestion you have less stomach acid. You have less breakdown of these important building blocks and then hes building blocks can be used to make these healthy brain chemicals that allow you to feel good sleep good and deal with stress. 

Evan Brand: Yeah. I agree. I was depressed when I had h-pylori could attest that my mood was not good and I lost a lot of muscle too, I mean you looked at me and you told me Evan man. I remember seeing a picture of you you had some muscles what happened to you. I was so skinny. Luckily. I’ve regained a lot of that muscle back but mood issues are definitely related to gut infections and I just want to talk about kids for a minute because a lot of parents blame their children or just being kids and that’s why they have a bad mood. I’ll tell you as a father of two mood issues are totally related to what’s going on with your kids diet as well and your kids got so if you send your kid to school with crackers and goldfish and other garbage that’s going to be inflammatory. But also it’s going to affect your blood sugar and they’re not having good protein with their lunch. It’s no wonder they crash. I have bad moods and then they are getting in trouble in school in the teachers calling you saying hey, you know Johnny hit another student today. What would have happened if his blood sugar was well regulated and go ahead. 

Dr. Justin Marchegiani: Yeah. I saw my son a picture of him. it’s snack time last week. It was really funny. All the kids are there had their lunch box is open and you could see he had like some green apples that were cut off. He had this like grass-fed organic, like beef jerky. They’re just really easy and Ill kind of cut off and he had I think some little bit of almond butter is a hit a really nice snack and he has seen a lot of the other kids. You see the Goldfish. You see a lot of sugary drinks. I’m like oh man, and these kids are just really getting their blood sugar on a roller coaster ride, and they’re not going to be as good I mean, don’t get me wrong nutritions not going to make your one or two year-old a three-year-old who is developing be a perfect angel but it’s going to significantly improve things and make it much much better and it’s in a provide the building blocks. They need one to heal in to grow their nervous system and connect all these synapses in the brain. All these neural connections from all these new skills that there that they are using but two are keeping a lot of the inflammatory dies and chemicals and Foods out that could make things even worse as well. 

Evan Brand: There’s been countless studies on the artificial colors and flavorings increasing the risk of ADD and ADHD. And a lot of these behavioral cognitive issues that are deemed as common so the teachers, you know, well just recommend that the parents speak with the doctor in the doctor puts the kid on Ritalin and that calms the kid down but that’s not the root cause he there’s a root cause of that and this is not hey, you know, Justin and I are awesome in our kids are better than you but I’m just telling you I’ve seen it my daughter hanging out a plate at a playground versus other kids where other kids in the same age group are having emotional breakdowns and they’re crying and rolling on the floor and screaming and just acting out like not how you think a kid would act out just not in control. Where is my daughter would be controlled or emotions would be controlled. Does she still have outburst and cry? Over silly Small Things. Yes, totally. But she’s three years old at the time of this recording. So I’m just saying that as a general rule, but also the chemicals to write when Im just talkin food. Were talkin that you and I both are you’re giving your son detoxification support. I give my daughter detoxification support. We’ve given both of our kids herbs to help treat gut infections and bacterial and things like that in the gut too. So maybe if the diet is dialed in but you’re not seeing any progress Improvement this applies for adults, but also children since were on the subject run a stool test on your 3 4 5 6 10 year old 15 year old kid and you may find gut infections like the H pylori just to mention as another root cause of the mood issue. 

Dr. Justin Marchegiani: Exactly plus it’s probably incidences where maybe some not-so-great food or more refined processed food slipped in with your child at all. And then you probably saw an outburst or behavioral issue, you know, we had an incident. I think on a birthday. We gave him a little bit of gluten-free cake and there’s a little bit of a crash afterwards we could see that in this by observations from you. So it’s all wrong with it. Right now. We definitely want to provide the hormone environment where it allows our kids to grow in NBA Staples possible think it’s really really important. We hit the the food component the digestion component. Let’s talk about four months. So obviously blood sugar has a major effect on our hormones the more I blood sugar goes up and down the more cortisol and adrenaline to get call to the rescue to to bar for that out to the mortgage Reno stress gets put on our body in archery know our stress handling system and the adrenals are a part of the hormonal system is connected with the sympathetic nervous system. So the sympathetic nervous system is the part of the nervous system that deals with fight-or-flight stress running fighting, fleeing confronting and that part of the nervous system the more it gets turned on or flare the more adrenaline and cortisol and stress hormones that are catabolic the break tissue down or going to be secreted and the adrenals also produce a significant amount of sex hormone precursor. So the more we’re stressed and dealing with the catabolic stress side last week and allocate resources to the anabolic repair and Recovery parasympathetic size. And then it makes it harder for us to recover put on muscle feel good turnover on neurotransmitters and just be able to deal with and adapt to stress. So there is that on one side and the adrenals affect the kind of men and women relatively equally but then women have their hormonal side from the ovaries that cycle throughout the month and that part of the Cascades a little bit more unique because cortisol, which is that major stress hormone that we talked about can also be made from progesterone. And so the more we are stressed, the more we can pull from the progesterone. I was thinking create more estrogen dominance so are relative ratio of progesterone estrogen which is typically 20 to 25 to 1 on average for progesterone Dash inserts asked you and this condition called estrogen dominance starts to occur with a percent of that returns coming up and this can create more mood issues more PMS kind of issues breast tenderness cramping back pain in the mood components of they want irritability anxiety depression. All those symptoms can happen as a result of that. So the more we can take away that up and down with our cortisol in the movie that takes out of that the less estrogen dominance will kick in.

Evan Brand: I just want to point out one key Point you’re speaking about ratios a lot of women come to us and say I’ve got so much estrogen. I’m so estrogen dominant know he’s not saying that you have tons of estrogen you saying in relationship to your progesterone. So it’s not that the estrogen is literally overwhelming and you have more estrogen than progesterone. that’s not what’s happening. Correct, correct? 

Dr. Justin Marchegiani: And it could be that your estrogen is actually really really high. Im seeing with a lot of my female patients is progesterone is low really low acids also low, but the ratio is still skewed. So Im seeing it like if you are as progesterone, right and he is estrogen what’s happening. Both are low, but progesterone is even lower. So it’s like that.

Evan Brand: Are you saying estrogen overwhelmed progesterone or would that be like an extreme case?

Dr. Justin Marchegiani: That being extreme case and almost all the time with cases like that. There may be an exhausting is pit Ashton being taken right? You’re definitely would see on the birth control pill side. You may not see it come back like that because a lot of egestion metabolites me to come back on the test cuz youre not, you know the actual the actual estradiol or estradiol hormone. They’re like the analog that it’s a metabolite that has still in that shouldn’t affect but it’s not coming back in the lab. So we just know the fact that if these levels are that high cuz you’re taking it then the warm out there going to be Might as well.

Evan Brand: OK make sense would be a mechanism to cuz if you had like yes High B6 recirculating all those hormones hormones would just make it works. Right if your recirculating hormones.

Dr. Justin Marchegiani: correct Plastics that I have seen no estrogen kind of facts whether [inaudible] egg. And then of course, you’re going to have hormones in the states right to give it a lot of estrogen type of hormones to make them fatter and kind of woke up. So to speak to the farmers can make more money on the slaughter there is that too. So that’s why you have to mitigate the toxins in the hormones and all the food and then you have to look at detoxification pathway. So well run on the docks tested a little gas gauge in the bottom left-hand corner of stop H3. it’s called the two methoxy hydroxy acid metabolites panel, or I should say reading and it’s a little gas gauge you want to at least in the middle, but you’ll see a lot of decreased methylation so it’s way to the left and that’s a sign that were not metabolizing are Estrogen. 

Evan Brand: Yeah, that’s important. So you have to address hormones and were not saying hey, you just go on thyroid medication. Like that’s not you know, this is a whole system here adrenals are connected to your thyroid thyroids connects. The brains involved. You mentioned the sympathetic nervous system. So if you’re somebody whos working 70 hours a week or not taking days off in your nervous system is so revved up. You can eat a paleo-diet and still have mood issues. 

Dr. Justin Marchegiani: Correct. Yep. that’s very possible. So we have those kind of hormone issue is and of course any women listening to it mood maybe one component of that. It could be other things as well could be the energy you could be back pain and cramping breast tenderness fluid retention. It could be all the above. 

Evan Brand: We should talk about toxicity and liver and chemicals and metals and stuff for a minute. But why don’t we just briefly mention autoimmunity and the role that I could play in hormone. So if you’re someone who has autoimmune thyroid, isn’t it possible that if you’re going from hypo to hyperthyroid, you may have some mood issues associated with that autoimmune attack or some day is the immune system is bang bang and then some days he knew system is not. 

Dr. Justin Marchegiani: So we look at hormones. it’s either ATM or ATF and it’s not you know, the ATM where you get money or the Alcohol Tobacco and Firearms government agency ATM is Adrenals Thyroid Male Hormones, ATF is Adrenal Thyroid Female Hormones. So we already talked about the adrenal and the female and the adrenal and the mail. Yes the same mechanism are as we complete DHEA and we kind of lets just say deplete our sex hormone precursor from the adrenals testosterone can also drop and then testosterone can have a significant mood depleting fact as well. So same on the men the little bit less has less pronounced because women have a hormone cycle that that rhythms up and down throughout the cycle or manner kind of like a flat kind of Foghorn. So to speak there isn’t quite as much rhythmic activity. Therefore it’s harder to knock that off so to speak but now with the thyroid issues women are going to be five times more prone to But men still listen because if you have symptoms, we definitely want to rule out the thyroid like you said just having low levels of thyroid hormone can create anxiety for sure and also having high levels can also create anxiety and irritability and also having Hashimoto autoimmune flares which would eventually end with low thyroid but like you mentioned that autoimmune flare can flare up your thyroid autoimmune response was Canaan cause more hormones to dump in the system, which can then create mood swings and irritability and anxiety difficulty sleeping and that can create issues as well. So you really want to look at autoimmune markers for the thyroid TPO thyroglobulin antibodies. You want to look at your thyroid levels because high or low or going to be significantly driving a lot of mood issues most of the time it’s going to be low because low is The Chronic place that people tend to end up but you will see with a cute flares that it will go high or more in the hyper side again in general. it’s going to be harder to catch that but if we see Levels of antibodies we can definitely assume those level of flares may be happening whether or not we catch the high-level on the test. If we know High antibodies are there then it makes sense that’s possible. And then of course some graves for sure, graves will be the other condition where were making antibodies. Where is thyroid receptor site antibodies are TSI with your thyroid stimulating immunoglobulins those can cause thyroid to make more hormones and that’s an autoimmune condition as well. Get ninety-five. 99% are going to be Hoshis, Hashimoto’s 1% grave. So in general, it’s more plausible. If you’re gambling person that you’re going to go on the Hashi side Less on the graves, but you know, you’ll typically were not going to ever run for Graves antibodies unless we see very high levels of thyroid levels like very high levels of T4 and T3, then we’ll definitely say, okay. Lets run TSI. Lets run thyroid what receptor antibodies.

Evan Brand: Your endocrinologist would probably even run even if you beg them. So a lot of times were ordering Special Labs because the primary doctor that someone may have the working with us. We may try to push them. Hey, you don’t try to get your endocrinologist to run this and they just won’t they’re very stubborn. Even when it comes to the TPO and TG antibodies despite the mass of massive increase even just the past 5 to 10 years of autoimmunity with thyroid. You would think that it’s like part of standard procedure and protocol now, but it’s still not my grandfather got his thyroid Labs run. It was literally just TSH and T4 and maybe like T3 uptake, but still nothing else and it’s just crazy. So what are they doing? They they modified your drug based on TSH, TSH one up. Lets give you a little bit more synthroid and people just don’t know why they’re not getting better.

Dr. Justin Marchegiani: Exactly and then conventional medicine will look at the graves thing and they’ll just say, okay. Well if you’re not in any hormone the right when you come in and your TSH is buried meaning it’s very low and let’s say below point 3.2.1. Then they may want to look Downstream at them some of those antibodies right? They may look at T4 and then I’m a look at TSI in the thyroid receptor site markers, but outside of that unless they see that they’re probably not going to do much. 

Evan Brand: Yeah, hopefully that’s what they do. But in some cases they may go straight to hey, we need to do radioactive iodine and try to just kill your thyroid off because youre youre over your thyroid overactive. I’m sorry that.

Dr. Justin Marchegiani: If they saw grave markers, that would be the next logical step. They didn’t want a thyroidectomy or they give u p t u or more time is all the shutdown of the thyroid activity or they give the radioactive iodine to just kill the thyroid to begin with.

Evan Brand: Not pretty.

Dr. Justin Marchegiani: No it’s not so thyroid flares because of Hashimoto’s well that may never come back on the TSH may never come out of balance enough for it to be an issue and your TSH may still be relatively in range, even though your antibodies are going up and down and your T3 may be low or could be going up or down to so you may not even see a problem with that.

Evan Brand: Alright so let’s talk about that was a good diversion. So I just wanted to make sure we hit. Community Casa del Carmen and no pesticides damaging the gut barrier damaging the blood-brain barrier. Even if you’re a vegan listening, please eat some meat but if you’re not, you know the vegetables or not benign neither you can still get a different herbicides pesticides excetera that still damaged your good gut bacteria and create leaky gut, even if youre saying everything I don’t need hormone me. Okay? Well the plants could do at 2 and then also the heavy metals, you know, we’ve seen a lot there’s just Google it look it up on PubMed your Googles evil because they’re suppressing a lot of help people. So use another search engine like one called ecosia ecosia. They plant trees every time you do a search every 10 searches the plant a tree for you so search on a Ecosia, PubMed Mercury depression or you know Mercury anxiety and any like bad mood something that you type up you can find a correlation with a various heavy metal. 

Dr. Justin Marchegiani: Excellent. I think it’s really really important. So heavy metals various pasta sides various toxins Roundup glyphosate. These are all going to be potentially stressors on your nervous system on your immune system on your brain. I told easiest thing is one just decrease the toxic overload. Just be eating organic higher-quality food. Drink really good clean filtered water. And then number two we can always give support to help run our Phase 1 Phase 2 and R2 toxification Pathways, that’s really important. We could do simple things like activated charcoal with you give sulfur-based Obito acids, we can get glutathione straight into liposomal former reduced form. We can get back Extra B vitamins and antioxidants like milk thistle with cumin and Resveratrol and really powerful things to help with inflammation and in donating antioxidants anything else. You want to highlight their on the detox. 

Evan Brand: I started over the weekend doing some glutathione and a nebulizer. there’s actually a brand out there which I can tell you about a bluetooth ion this mixed with a sodium bicarbonate that you can make Saline solution. I’ve read a Stephen Buhner, the herbalist that you and I love because of his work on Lyme and co-infections. He made a COPD protocol for people suffering with asthma and other lung conditions and came up with a nebulizer protocol with essential oils. And so I’m doing the nebulized glutathione by itself and you just need to put the face mask on you got the nebulizer and I just took a of 200 mg of glutathione intranasally and I tell you my brain yesterday was so clear like, amazingly clear and I’ve actually spoke with some of these people at the company who’ve gotten their patients off of IV glutathione and onto the nebulizer because they don’t have to drive anywhere to get poked with a needle is much cheaper and the results are being seen much better because it’s getting through the blood-brain barrier when you inhale the glutathione vs. IV is not so that’s like my new development on detox and I haven’t done it enough yet to to give you the full, you know the whole story but for right now, My story is very positive. 

Dr. Justin Marchegiani: Excellent. Very good. So I think we talked about some of the toxic things. And again, it’s pretty simple. it’s like you just got to look at the food. Look at the environments try to increase sweating the infrared sauna good clean hydration could get a grill to go clean water filter or the ones that I specifically used Evan probably has some as well and you can look at his shop as well. But that’s kind of things. I actually use and I recommend personally clean water organic food being able to digest your food and then we talked about some of the various binders that we can do like chlorella for that some of the heavy metals activated charcoal as it’s a really good multi-tasker for a lot very spent the night Clays or folded minerals are really good too. And then they also you know from what we may also do things like Z light or maybe even Coley star means to help that bind up some of that mold as well that could be there environmentally if that’s the case then well have to do some testing on the house and and look again. Is the root cause of that Dilantin I have a guest that were going to get on just a few minutes. It will talk all about that in the next podcast. I will be right after this show. 

Evan Brand: Yeah, we got to wrap it up so that you all can chat about mold. it’s going to be fun. But the sauna would be the last thing I would add animal wrap it up the sauna and I love sweating sweating is the key and you can look at if you just look up PubMed typing like ochratoxin sweat. You can read that mold toxins. In fact do come out when you sweat so there is proof behind that and there’s a reason that our ancestors did like sweat lodges and some of these ceremonial practices they sweat their butt often those things and they were probably detoxing too good thing for them as they did not have any of the hundreds of thousands of manmade modern chemicals that we have today. 

Dr. Justin Marchegiani: I think it’s important. that’s great. Awesome animal today was a great chat as always. Hope everyone enjoyed the podcast in the interview before you put your comment down below. Let us know things that you have used to help you detoxify good experience that you had and if you enjoy today¡̄s show, give us a share. We appreciate it, and you can write a review at and We appreciate ya¡̄ll. Everyone has a phenomenal day and we’ll talk real soon.

Evan Brand: The clinical websites. If you want to reach out to Joe is clinically, please do so at his sight You can reach out around the world. We can send test kit’s to your door. You don’t have to drive anywhere and wait in a boring dirty doctors office and read People magazine. You can do it from your house. So, and then my side is We look forward to helping you were very grateful for the opportunity.

Dr. Justin Marchegiani: Love it, excellent. Awesome Evan, have a phenomenal day great chat with you is always will be back next week. Thank you. Everyone. 

Evan Brand: See you later. Bye.

Dr. Justin Marchegiani: Bye. Bye.


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