Common Causes of Weight Loss Resistance

Weight Loss Resistance

By Dr. Justin Marchegiani

Weight loss is one of the common issues faced by many of us. Sometimes we think we have tried everything, but weight loss just never really happens. Watch this video and learn about reasons why we can’t seem to lose weight effectively. Gain valuable insight about the factors affecting weight loss resistance and determine if any of these factors apply to us.

Today’s talk will be on weight loss. Essentially, weight loss resistance. I see many patients here at the clinic have issues with weight loss. Some of the common things that I find that really are kinda the main cause of weight loss is because you didn’t try, you’re kind of on that calorie roller coaster. And every few years, you notice your rate keeps up and going up. And it kind of feel like it just may never stop.

Factors causing weight loss resistance:

  1. Inflammation
  2. Gut issues
  3. Toxins
  4. Over exercising

Factors Causing Weight Loss Resistance


Inflammation is a really common factor to chronic weight gain. What is inflammation? Inflammation, there’s a couple of different kinds.

Acute inflammation will be something like cut or sports injury. So cut for instance, you’re body’s going to form clotting factors that is going to produce a scab, and eventually that scab will let go. That’s great.

What we find in today’s society is we have chronic, systemic inflammation. The body is systemically inflamed due to diet and lifestyle factors. Man is causing essentially stimulating a hormone called cortisol. Other hormones, still we have cholecystokinin, but just to keep it simple for this generalization.

Cortisol, essentially, is driving belly fat bad, driving fat that is actually breaking down protein and muscle. And it’s interesting to know that a lot of receptors for cortisol are actually right around our bellies and hips.

So our real first goal is addressing weight gain, knocking down that cortisol. That’s one.  Where does cortisol come from? We’ll just kinda go over couple of a few factors you may find in my patients coming here.  

What causes inflammation?

Causes of Inflammation

Foods being the first thing that we see that can attribute to inflammation. When you have to do it every single meal,
and when you’re either putting food in your body that’s creating the anti-inflammatory state or you’re putting food in your body that’s creating the pro-inflammatory state, that’s one. So eating the right fatty acids is very helpful. People on this called low fat kick today, they’re not getting the right nutrients and I suppose that’s one factor.


So if you’re eating lots of peanuts and different foods, like grains for instance, then you’re increasing your mycotoxin exposure, it is going to have a huge effect when you gain fat.

Want to know more about the causes of inflammation? CLICK HERE


So as we eat these foods that will cause this inflammation around the gut. And essentially, we can see inflammation on the skin. But in the inside, we can’t really tell what’s going on.  So we’re eating foods that, in the inside, will cause the inflammation. It will cause inflammation, then couple of things happen.

We have our different microvilli in the inside of our intestines that are our little vacuum cleaners. It suck up nutrients. So one may suck up vitamin C, some calcium, some iron, etc. So if we get clogged our vacuum cleaners from inflammation, we can’t really take in a lot of the nutrients that we need. It’s important that these nutrients are using their radar energy systems. So it makes sense that we can’t get the nutrients that we need. Our energy system maybe a little bit low.


Toxins are another huge factor that we see. Your body is very intelligent. It knows toxins are dangerous to the organs, dangerous to the brain. Well it does its best job to sequester them. Sequester meaning it stores it in the fat and keeps it away from going to systemic circulation. So if our body is constantly expose to toxins, isn’t it a hard time letting go of fat? Because you notice that fat needs to be there to help buffer that bad toxin exposure. So if we do our best to decrease toxin exposure, mycotoxins, food allergens, etc., we  put our body into a huge step of healing and feeling better. And where we see that fat that maybe there’s a safety net, so to speak.


Now the common thing you see, super common is over exercising. Patients are doing exercises that are actually increasing cortisol. You can check the medical databases, that long distance cardio, especially marathon running, anything that I consider over 45 minutes to an hour, long-term is going to increase cortisol secretions.

Then again, we talk about cortisol, the receptors are on your tummy, they’re on the hips. So at the same time, you’re adding on hip fat and belly fat and you’re also burning up muscle.

So, we like to get people’s  exercise dialed in precisely.  And a lot of times, it’s not about getting working harder, it’s about working smarter. So short bursts, shorter range and high amplitude burst is going to be a much better solution.

Summary and Recommendation

Summary and RecommendationsNow, so overall, we looked at some exercise components. We looked at some food components, and toxins, toxic exposure components to how weight loss tends to accumulate. And over time, what we find is patients with a sluggish metabolism, overtime, tend to accumulate weight.  So really the key is to address the metabolism, fix it. It’s important that we do not want to lose some weight to get healthy. You get healthy and then you lose weight. So it’s kind of a different way of thinking.

So I hope this video helps everyone here. And any questions, feel free and let me know. We can always set up a consultation.

Are you having trouble losing weight? CLICK HERE to ask an expert about it. 


The entire contents of this website are based upon the opinions of Dr. Justin Marchegiani unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Justin and his community. Dr. Justin encourages you to make your own health care decisions based upon your research and in partnership with a qualified healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Dr. Marchegiani’s products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using any products.