Iron Overload, Malabsorption, & Autoimmune Issue | Podcast #198
In this video, Dr. Justin Marchegiani answers health questions such as problems with Iron overload, hair loss, malabsorption, Epstein-Barr virus, depression, and autoimmune.
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Dr. Justin Marchegiani
In this episode, we cover:
00:30 Iron Overload Relating to Vision, Energy and Oxidation Issues
02:00 Healthy Hair and Autoimmunity
05:00 Malabsorption During Intermittent Fasting
07:20 Recovering from Epstein-Barr Virus
11:30 Depression, Protein, and Brain Chemistry
Dr. Justin Marchegiani: He-hey! Hey! Dr. J in the house. Evan, how are we doing today, man?
Evan Brand: Hey, man. I’m doing great. Happy Monday to you.
Dr. Justin Marchegiani: Happy Monday to you. How was your weekend?
Evan Brand: It was great! Uh, actually, I’m feeling much better. I donated some blood again, which I was telling you off
Dr. Justin Marchegiani: Yup.
Evan Brand: My vision literally cleared up, like right after donating blood. So, this is very interesting because you find nothing in the literature about vision and high Iron. At least maybe I just— unless I missed the research— I didn’t find anything. But when I got the blood out of my body, “Boom!” My vision was cleared. [crosstalk] Do you have any explanation—
Dr. Justin Marchegiani: I know a podcast on this recently too with elevations in Iron. I think back in May, we did a nice podcast on this— how that can create some oxidation issues. It could have been some kind of oxidation reaction. It could have been just maybe putting some stress on your antioxidant reserves. It’s hard to say, but I think it’s good everyone
Evan Brand: Yeah, and for people that are— you know, for women, specifically that are menstruating, this probably not an issue that’s gonna happen but we do have quite a bit of male listeners too. So if you guys are having any type of symptoms that are just not making sense, run that Iron panel because I was also noticing my mental energy was lower.
Dr. Justin Marchegiani: Totally.
Evan Brand: and— and when I left the Red Cross, my mental energy had skyrocketed. So, Iron, energy levels, uh— in terms of sleep, grogginess, mood— it could all be related to Iron overload, and I suspect more people have Iron overload. Males; suspect Iron overload, and— and most people don’t have a clue.
Dr. Justin Marchegiani: One hundred percent. Well, let’s dig in here. We got a couple of questions here. One from Amy. Uh— what can man and woman do for hair loss? Well, first thing, for both sexes, is make sure your gut function’s doing well because if we’re not absorbing good fats and good proteins, we’re not gonna have the building blocks to make our healthy hair. That’s number one. Number two on the female side, and even the male
Evan Brand: So what would that be? You
Dr. Justin Marchegiani: Above 3.0. Above 3. A 3.0 or above, I think is adequate. Low th— You need thyroid hormone to help mature and grow the— the hair follicles. So, low thyroid hormone levels could potentially drive hair follicle loss. In men, you can also see increases of DHT can start Oxygen and blood flow to the hair follicles so that’s why things like Arimidex had helped or you can do nal— Natural 5-alpha Reductase inhibitors like Selenium, Like Lycopene, Saw Palmetto,
Evan Brand: Yeah, and look for the antibodies, too. And— And you said that without saying it. I know it’s in your brain but you didn’t say it-
Dr. Justin Marchegiani: Oh, yes.
Evan Brand: -which is, “Look at the antibodies,” because almost every single woman that you see and almost every single woman that I see has some type of an autoimmune component to her thyroid, so just making sure you get those antibody levels down.
Dr. Justin Marchegiani: Yeah, ni— fif— over 50% of thyroid issues are autoimmune, so when we talk about thyroid, autoimmune is already being plugged in
Evan Brand: Any infections— addressing infections— ‘cause my [crosstalk] Reverse T3— Yeah. My— My reverse T3 was too high and a lot of it, I believe is my gut issues.
Dr. Justin Marchegiani: Yeah, absolutely. Now, Gabe writes in, “Can Intermittent fasting help me absorb nutrition better? Heard it also calm inflammation. I’m dealing with malabsorption.” I’ll let you tackle that one first, Evan.
Evan Brand: Yeah. So, intermittent fasting. I mean,
Dr. Justin Marchegiani: No, you’re not. Again, we’d had
Evan Brand: Yep. So, I mean, it c— it could be part of a healing protocol but it’s not the cure-all.
Dr. Justin Marchegiani: No. It’s not— It’s not root causal. There’s not— There’s no magic in eating nothing. If that’s the case, anyone that would be on the streets or homeless that didn’t eat, you know, would have perfect health, and that’s just not how it is. And I get that’s an oversimplification but it’s true.
Evan Brand: Yup.
Dr. Justin Marchegiani: We actually need nutrients to run our pathways.
Evan Brand: We do.
Dr. Justin Marchegiani: Uhmm— Justin writes in, “Dr. J, any recommendations on helping recover from
Evan Brand: Yup.
Dr. Justin Marchegiani: Absolutely love that. Uhm— Longterm, I think Ashwagandha’s wonderful or the product called Ashwagandha Supreme. I love it. I take it for capsules during the week. Maybe—
Evan Brand: You do—
Dr. Justin Marchegiani: …stress.
Evan Brand: Do you do evening doses as well or do you just do Ashwagandha during the day?
Dr. Justin Marchegiani: If I’m stressed and I’m feeling like a little bit just like I had a long day with patients, I’m feeling really stressed, I’ll do that maybe some GABA and Magnesium just to kind of chill out.
Evan Brand: Yeah.
Dr. Justin Marchegiani: But it can be helpful. It’s great long-term immune support. It’s great adrenal support, Cortisol modulation, and balancing good HPA Axis support. Also with that, we can do Silver. We can do Monolaurin. We can do the Reishi
Evan Brand: Yeah. The Monolaurin’s great. The Lauric acid formula comes from coconuts. I have one called Biofilm Buster that I use, and that one is a— is a potent antiviral. And you really turned me on to the Silver, so the Silver could be useful too. And then, you mentioned the Reishi. I’d say, any of the mushrooms too, but Reishi would be probably the go to. Cordyceps, Shiitake, Maitake-
Dr. Justin Marchegiani: Yup.
Evan Brand: -could be helpful. And then Astragalus. I’m a huge fan of Astragalus. I love taking it. I take it almost
Dr. Justin Marchegiani: Yeah. Totally. “Any knowledge and opinions on the health benefits of carbon-60?” Never heard of it.
Evan Brand: Yeah. I have. Yeah, so the Carbon-60— it’s like this patented version of Olive oil. And—
Dr. Justin Marchegiani: Oh.
Evan Brand: -suppose to just be like this miracle cure, and everyone is taking it. Let me look and see if there was another ‘cause I had heard there’s another one that’s different though. So that’s one, and there’s another one that’s called C60, and it’s something different. It’s Avocado oil. And then there’s another one. That’s C60 Coconut oil. And—
Dr. Justin Marchegiani: Yeah. I’m familiar with the like the MCT Oil. Like the— the Hexanoic acid. Like, you know, Dave Asprey has it in the Brain Octane. Other people have it as well, which is primarily used by the brain. I’m familiar with that. That has six Carbons on it for sure.
Evan Brand: So, for example, a 4-ounce bottle of this stuff is a hundred dollars.
Dr. Justin Marchegiani: That’s really expensive.
Evan Brand: And it says— It’s a— It’s an—a monomolecular pure C60 suspended in Avocado oil. I mean, look. Anytime that there’s something promoted as like a Silver bullet like that, I just am a little bit skeptical. I’ve not personally taken it so I’m not gonna tell you that it’s not awesome, but it says here. What they do, get this. It says, “Here’s how we create C60. We use rods of elemental Carbon, vaporized by electricity in a Helium atmosphere. This method imitates the way C6— C60’s made in the atmosphere of giant red stars.”
Dr. Justin Marchegiani: That just sounds a little bit out there for me. [laughs]
Evan Brand: For a hundred bucks for
Dr. Justin Marchegiani: Oh, yeah. That sounds a little crazy. I would need a lot more of clinical feedback on people that have had amazing results. But I mean, if
Evan Brand: For a 16-ounce bottle, 370 dollars.
Dr. Justin Marchegiani: Crazy.
Evan Brand: Yeah.
Dr. Justin Marchegiani: Crazy. Crazy.
Evan Brand: So, let’s see. Let’s see like before and after Lab results. Okay. It promises to do this with Mitochondria. Okay. here’s before and after.
Dr. Justin Marchegiani: Yes.
Evan Brand: Nothing else was done, except this supplement. Look at what it did to the mitochondria.
Dr. Justin Marchegiani: Yes.
Evan Brand: Then I would be like, “Okay. It’s a miracle.”
Dr. Justin Marchegiani: Exactly. Charlie writes in, “When doing the 201 CAR Test, will
Dr. Justin Marchegiani: Try to be as stationary as possible.
Evan Brand: Yup. Uh— Do you want me to
Dr. Justin Marchegiani: Yeah.
Evan Brand: I’ll read it for you.
Dr. Justin Marchegiani: Yeah, go ahead.
Evan Brand: “I’m dealing with depression, etc. They tell me plant-based diet. Been doing it for four weeks; not much success. Any thoughts? I’m not going back on meds.”
Dr. Justin Marchegiani: Yeah. The big problem is a lot of people need protein for helping brain chemistry and it’s hard to get enough protein in a plant-based diet. It’s
Evan Brand: And I know we’ve done podcasts all on depression, so just go on Justin’s site, justinhealth.com, or go on my site, evanbrand.com. Type in depression, you’ll find entire hours dedicated to this. Also, I believe uh— Justin and I both have done a YouTube video— I know I have for sure— on Depression and some of the stuff that helped me ‘cause I was depressed for a long time. So, just go like on YouTube, type in Depression, Just in Health or Evan Brand, you’ll find the videos.
Dr. Justin Marchegiani: Totally. Cool. Let’s keep on rolling. “Is there a supplement to help me fall asleep and stay asleep? I wake up every night, one to three times, and have uh— have trouble sleeping sometimes as well.” Evan, what do you think.
Evan Brand: I mean, that’s hard, right? There could be a million reasons why you can’t fall asleep. What if you’re checking your phone? You’re probably looking at your phone on social media before bed, which is
Dr. Justin Marchegiani: Yeah. If there’s— If it’s an Anxiety issue, sometimes women that have lower Progesterone levels, that could be a problem too. So there’s a potential— bunch of potential things there and it’s different for each sex. So I mean, we have to know kind of male, female, menopausal, cycling whatever— That— That helps a lot too.
Evan Brand: Yeah. There was a follow-up from the same person here. “What is the reason why I wake up with sore legs? They feel heavy. Uh— I mean, and no exercise a day before.” That could just be Mitochondria. What do you think?
Dr. Justin Marchegiani: It could be Mitochondrial stuff. I’d look at how much amino acids you’re getting and just try to get some good mitochondrial support and some extra amino acids in and see. Uhm— I also want to know, what’s your day like? Are you at a
Evan Brand: I think we’ve got— you’ve got like
Dr. Justin Marchegiani: Right.
Evan Brand: -try to hit one more.
Dr. Justin Marchegiani: Absolutely. “Any thoughts on Iodine for thyroid health, Lugol’s, Iodoral, or
Evan Brand: Well—
Dr. Justin Marchegiani: So, in general, like Nasient’s a big thing. I think
Evan Brand: Yeah. That’s— That’s what I was gonna say was that if there is autoimmunity, you got to be careful ‘cause it can make it worse and we’ve seen the antibodies go up from people that went to a practitioner-
Dr. Justin Marchegiani: Yes.
Evan Brand: -and they just got like
Dr. Justin Marchegiani: Hundred percent. Cool, Evan. Anything else you wanted to mention?
Evan Brand: I think that’s it. I mean, we can hit up the other questions, you know, next week, but we’ve both got a roll. And so, in the meantime, if you want to reach out to Justin for help, got to his site, justinhealth.com, and if you want to check out me, you can check out evanbrand.com. We love helping you all. We love talking to you and we’ll be back next Monday.
Dr. Justin Marchegiani: Yeah. I’ll be back on Friday for my live Q&A, guys, so any questions I didn’t get to, we’ll hit it up there. Give me a like. Give me a thumbs up. Give me a share. Palm that bell. Tell a friend or family member. We’re here to help you all-all. We love interacting. I appreciate you guys being uh— active participants in this conversation.
Evan Brand: Take care.
Dr. Justin Marchegiani: Evan, take care. Bye.
Dave Asprey in Brain Octane
Dr. Edward Group at Global Healing Center
Hashimoto’s Disease and The Infection Connection
By Dr. Justin Marchegiani
Hashimoto’s Disease, is an autoimmune disease, a disorder in which the immune system turns against the body’s own tissues. In people with Hashimoto’s, the immune system attacks the thyroid. This can lead to hypothyroidism, a condition in which the thyroid does not make enough hormones for the body’s needs.
While a healthy immune system resists infection, a weakened immune system welcomes it in with open arms. Infections thrive in unhealthy environments. And once a bug (parasite, bacteria, fungus, or virus) moves in, it can be difficult to exterminate.
Infections can worsen autoimmune conditions of the thyroid (such as Hashimoto’s thyroiditis and Grave’s disease) and other parts of the body. It can also create inflammation, disrupt detoxification, and wreak havoc on the digestive system. So the bug has moved in—here’s what you need to know to minimize infection and protect your thyroid.
Bacteria in the Gut: The Good vs. the Bad
Our gut needs good bacteria to function and thrive. A ratio of 80% good bacteria and 20% bad is a healthy level of gut bacteria.
An imbalance in this bacteria (e.g., 80% bad and 20% good) is called dysbiosis. Overgrowths of yeast (such as Candida) or infections (such as H. pylori) can cause this imbalance.
Good bacteria consume toxins and send nutrients to the body. Bad bacteria consume nutrients and send toxins to the body. Those bad bacteria can lead to a leaky gut.
Small intestinal bacterial overgrowth (SIBO) is a condition that’s driven by bacteria that’s migrated from the large intestine into the small intestine. They’re in the wrong place. This can produce toxins in the gut and disrupt peristalsis (the wavelike contractions that move stool through our intestines).
If we have a delay in peristalsis, we can reabsorb a lot of the toxicity. This is called autointoxication.
Infections in the gut can be particularly challenging and difficult when they accompany an autoimmune condition.
Infection with an Autoimmune Condition (Hashimoto’s)
When we have an autoimmune condition, this simply means the body is making antibodies that can’t tell the difference between the invader and the body itself. Antibodies are proteins that fight invaders such as bacteria and viruses. So while the antibody may fight the invader, it will also attack a specific part of the body.
In the autoimmune condition Hashimoto’s thyroiditis, the body makes antibodies to thyroid peroxidase (TPO) causing thyroid breakdown. In Grave’s disease, the body makes antibodies to thyroxine-binding globulin (TBG) causing thyroid breakdown.
Infection Leads to Leaky Gut Leads to Thyroid Breakdown (Hashimoto’s)
The bad bacteria (overgrowths of infection) in the gut pave the way to a leaky gut.
When our gut becomes leaky, undigested food particles pass through “leaks” in the gut and enter the bloodstream. The surface proteins on gluten, for example, can look very similar to the thyroid and cases of “mistaken identity”. This is known as molecular mimicry. This is true for other body tissues as well. Dairy can look like the pancreas, for example.
So the immune system starts making antibodies for the thyroid because it can’t tell the difference. And then know, the thyroid is under attack.
Infection and a leaky gut are two of the prime mechanisms that exacerbate the breakdown of the thyroid.
Infections That Impact the Gut and Thyroid
A few common infections that are found when dealing with leaky gut and thyroid issues follow:
- Helicobacter pylori (H.pylori)—This bacteria is common in greater than 50% of the population. It can drive autoimmunity in Hashimoto’s. Also, it is linked to other autoimmune conditions. It is transmitted through saliva or fecal contamination.
- Borrelia burgdorferi (Lyme disease)—This bacteria looks similar to the thyroid, so it can exacerbate autoimmunity. It can be acute or chronic and is transmitted by the deer tick.
- Yersinia enterocolitica—This parasitic infection can trigger thyroid conditions and autoimmunity. It is transmitted through contaminated food and water.
- Candida—This fungal infection disrupts digestion, throws off good-bad gut bacteria balance, and creates constipation. It is transmitted through direct contact and can be spread by contact with contaminated objects.
- Epstein-Barr virus (mono, the kissing disease)—This virus causes an imbalance in the immune system and is present in 80–90% of the population. It’s connected to many autoimmune conditions, including Hashimoto’s. It is transmitted through saliva.
Removing the Infection Isn’t the First Step
Addressing infections can be stressful on the body. Being unhealthy means having an imbalance in gut bacteria, poor gut function, adrenal issues, energy issues, a bad diet, poor sleep habits, etc. When we are unhealthy and we knock out an infection, our body has to deal with the dead debris.
The infections are like soldiers fighting on a battlefield. We introduce our natural or herbal antibiotics to destroy the infections. Massive numbers of soldiers (the infections) are falling all over the battlefield.
Our immune and detoxification systems have to send out the medics to help pull the soldiers off the battlefield, but there are just too many soldiers (too much infection debris). The medics (our immune and detox systems) get backed up. And there’s a huge line of soldiers that still need help.
Once our immune and detox systems are backed up, this creates a Herxheimer reaction. In this reaction, the harmful biotoxins from the infectious debris accumulate. Then, they start creating stress on our immune, detoxification, and lymphatic systems. The medics are stressed—they can’t keep up.
To eliminate the stress of infection debris on the body, removing infection should be the fourth step in a five-step (the 5Rs) strategy that can be found in detail at this link, and briefly below:
- Remove hyperallergenic foods.
- Replace enzymes, acids, and bile salts.
- Repair with healing nutrients and adrenal support.
- Remove infections
- Reinoculate with probiotics.
Removing infections can leave the gut empty. It will even knock out some good stuff, too. And weeds (bad bacteria) tend to grow automatically in this world. Gardeners don’t go to Home Depot to pick out weeds to plant. Weeds just happen. So it’s important to reseed the gut with the good bacteria after removing infections.
Studies have shown that when certain infections are removed, we see a significant decrease in the amount of thyroid antibodies. This means that these infections are driving the immune system to destroy the thyroid faster. So if we can knock out the infections, ideally naturally, herbally, and safely, we can reduce the self-destruction of our thyroid tissue. That’s the goal.
Featured image from my.microbes.eu.
Benvenga S, Guarneri F, Vaccaro M, et al. Homologies between proteins of Borrelia burgdorferi and thyroid autoantigens. Thyroid, 2004 Nov; 14 (11): 964–66.
Corapçioğlu D, Tonyukuk V, Kiyan M, et al. Relationship between thyroid autoimmunity and Yersinia enterocolitica antibodies. Thyroid, 2002 Jul; 12 (7): 613–17.
Molina V, Shoenfeld Y. Infection, vaccines and other environmental triggers of autoimmunity. Autoimmunity 2005 May; 38 (3): 235–45.
Tomer Y, Davies TF. Infection, thyroid disease, and autoimmunity. Endocr Rev, 1993 Feb; 14 (1):107–20.
Wentz, Izabella. Hashimoto’s Thyroiditis: Lifestyle Interventions for Finding and Treating the Root Cause. Wentz, 2013: 238–241.