Conventional GI Workup vs Functional Gut Health Program | Podcast #297

If you’ve ever wondered how functional medicine differs from everyday conventional medicine, this is the podcast for you. Dr. J sets out to explore conventional medicine GI workup vs. functional medicine gut-health workup. It’s a compare and contrast while looking at what chronic conditions may be missed by conventional medicine. Check out for more info.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, they cover:


0:29     Gut Issues, H. Pylori

7:49     How Are These Detected?

18:04   Tests

24:16   Compare and Contrast of Treatments

32:10   Saliva Secretions

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Dr. Justin Marchegiani: Hey guys, it’s Dr. Justin Marchegiani here really excited today we’re going to be having a phenomenal podcast on the topic of conventional medicine, gi workup versus a functional medicine gi workup. We want to just kind of give you guys a little compare and contrast and talk about where others shine and where others may be better, especially for most people who have chronic health challenges that may be missed by your conventional medical workup. Before we dive in, Evan, how are we doing today, man?

Evan Brand: Doing really well, this podcast started with a story. quick story. The best man in my wedding. He called me last night and Hey, how you doing? Everything’s good. Okay, awesome. And then hey, I need some help with my wife. She’s been having a lot of gut issues for the past several months. She went into conventional doctor then went to a I’m assuming she went to some type of a specialist. Gi probably I told them about her issues which were bloating, major abdominal cramping, cramping, and pain, floating stools, possibly some changes with mood, but I don’t know if that was brought up to the doctor. So just conventional gi stuff and some pain that was radiating to the back. So pain in the front that was in radiating to the back. And her protocol was no testing. I don’t even think they did palpation they didn’t do physical exam. I think it they just listened. And then they said, okay, buy this probiotic. This probiotic was something that you and I looked up. It was one strain of bacteria in the bifido family, and it was loaded with fillers. And it was what’s considered a consumer grade product, meaning you don’t have to be a practitioner to get it. And it was just loaded with garbage fillers and sugar and other stuff. It had sucrose like why do you have sucrose so that was it. So that was it. And so then When you and I called this morning, I just said, Look, we’ve got to cover this because she got nowhere. And she spent all this time sitting in a doctor’s office waiting. And now she’s no better off. So I talked with her for a little bit. And we made a protocol for her that I think is going to be far, far better.

Dr. Justin Marchegiani: That’s great. Yeah. So really excellent. And when we see patients on the functional medicine side, most have already gone through a pretty thorough, conventional workup. So, you know, my perspective on a lot of this, not that I’m a trained gastroenterologist, not we’re functional medicine practitioners. But I see lots of patients who have already been through the gamut. And so I really try to understand what’s already been looked at what’s been tested, and you see a pattern, you know, when you see a couple hundred patients kind of go through these intense workups you see a pattern of what’s already been done, and you can kind of see what’s been missed, or kind of what their perspective is. So, most conventional gi doctors, you know that these are ones that are not functional medicine and nutritionally change right 90% are going to be in the conventional Category right there just following the typical internal medicine gastroenterologist, kind of best practices workup. So most are coming in they’re doing a history, they may do a physical exam some kind of a palpation to see where inflammation may be in the intestinal tract right certain areas may lead them to think certain things right, upper left quadrant, right my left that could be stomach kind of things maybe pancreas things, upper right. Could be more on the gallbladder liver area, you know, bottom, like mid left could be more spleen, bottom right mid right could be more intestines, and then lower right lower left could be either appendix on the right could be colon ascending on the right, descending on the left sigmoid colon on the left so that you kind of get a decent area. If you just know the general anatomy of what the inflammation could be Now, the next step is going to be depending upon you know, how invasive that things need to go right. They may recommend a capsule or endoscopy just to get a window. What kind of inflammation is in the intestine and then almost always though, they may need to go deeper into an actual endoscopy which is scoped down the mouth. Alright, colonoscopy is going to be scoped up the rectum to look in the colon area right you have your sigmoidoscopy, which is the last part of the colon before, stool goes into the toilet. And then you have all the way up the different intestinal tracts in the colon, right you have your descending your transverse or ascending and then on the upper side, you have your tummy. You have your tummy on the endoscopy, and then you have the first part of that small intestine. So obviously on the colon they may be looking for if you’re older, maybe polyps, which could be precancerous, they may be looking at inflamed tissue. It could be inflamed tissue from a ulcerative colitis when maybe there’s bleeding. It could be inflamed tissue from Crohn’s disease, which may manifest a little bit differently higher up usually, and usually there’s some level of skip lesions we’re all sort of colitis may not have that on the upper side. There could be ulcers in the stomach, right? Those are all possible things. And then there may be other tests to look at the levels of blood there may be things done like a fecal occult blood, where they’re testing microscopic levels of blood in the stool, maybe looking at calprotectin, which are inflammation markers in the intestines, maybe doing a barium swallow to look for any fistulas or blockages or even bleeding. On a barium swallow those are all like conventional things, they may pull out a ultrasound to look deeper at pancreas or gallbladder or liver, if some of that area comes back and flame or to even monitor monitor some of the krones type of inflammation. Some of the more progressive gastroenterologist are starting to do more of the breath testing, the lactulose breath testing, which may look at hydrogen and methane gases. Some may even do a glucose type of breath testing, it looks at more of the bacterial imbalances in the stomach. These are all other more progressive, forward thinking kinds of functional medicine, functional GIS, maybe doing that. Not a lot do that though. Then after that you have your conventional blood tests which could look for inflammation or immune cells or calprotectin. Or actually no calprotectin has to be in the stool but you could look at C reactive protein, you could look at immune markers, right. You could also look at the blood, you could just look at red blood cells, hemoglobin, hematocrit, iron, because if you’re losing blood, you may see it on a panel like that as well. And then some may also do stool testing. Now they may do more of your conventional stool testing that is less accurate, less specific, maybe not the more cutting edge DNA testing that’s looking for microbes that are more sensitive level parasites, H. pylori virulence factors Candida sibo bacterial overgrowth, right elastase deatta krijgt elastase is an enzyme markers, the adequate amount of digested fat marker. So these are things that they they’re typically not going to look at that we’re going to really dive in deeper because we’re doing a real functional assessment for what’s happening in the gut conventional medicines more looking at a pathological assessment, where we’re looking at PE, here’s optimal digestion what’s functionally not working compared to optimal, because there’s a big spread between, you know, being functionally optimum, and being disease and pathological is a big spread. So the problem is a lot of people are in between, this is where a diagnosis happens. This is where optimal is maybe somewhere in between that area and they’re just not going to get picked up. They’re not going to get assessed or found. And that’s where most 90% are going to be in no man’s land. In regards to their assessment or diagnosis, now we can go into treatment next, but I’m going to just pause there and give you a chance to comment.

Evan Brand: Sure, yeah. Good. Good overview and H. pylori breath testing is sometimes done. 

Dr. Justin Marchegiani: I forgot H. Pylori. I’m sorry. Yes. H. Pylori as well.

Evan Brand: Yeah. So that’s something where, you know, if we, typically what Justin and I are doing when we work with someone is we’re going to have them send us any labs that they’ve done. Maybe the last six months, maybe a year. If We think it’s still relevant. And we’ll take a look at it. So each problem our breath testing will see those. But the truth is that there can in with all these conventional, less accurate tests, there can be an issue with false negatives. So that’s even more frustrating for the client or the patient because they come to us. They’ve got five or six things they’ve done with the GI people, and they still don’t have any answers. And of course, they don’t have any action plan or protocol. So for me, before I figured out that I had h pylori and parasite issues I did the barium swallow, you drink barium, which is terrible. It’s like drinking chalk. And then you go and you get an X ray. I was having a ton of gi burning upper gi burning so that’s where they did the you swallow it and then you basically lay back they then X ray you and try to see what was going on. And, of course, I wish I didn’t have that done because it wasn’t functional. And it gave me no answers. And all they said was Yeah, you may have some inflammation, they just call it idiopathic gastritis and then they send you on your way. No, yeah, meaning Idiot gastritis we don’t have a clue. And then they gave me the recommended acid blocker and the anti spasmodic and sent me on my way. And I said, I’m not taking them, don’t even give me the prescription pad, I’m not going to take it. And then Luckily, I was able to do functional testing, which then confirm the bugs that I had. So, so I’ve been there, I’ve been there, done that, and you made a great point, I just want to kind of restate it in a different way just to make people make sure people are clear with it, which is this this huge, wide, like you call it a spectrum, the spectrum of all the way over on one side is death disease, celiac krones, just like some sort of like you said, a pathological diagnosis. And then on the other end is like optimal gut health. And you could be so far down this hole, very, very close to pathological level of tissue destruction in the gut, but still not enough to technically be celiac or be krones or be this or that. So until you get to that level, to the conventional world, you’re fine. You just got to keep that Go and keep going, keep going until you get to the level of tissue destruction where you could say you are celiac or Crohn’s or pain, colitis or whatever. Now we can prescribe you this drug. And that’s it. And I’ve actually had doctors tell some of my clients during their workups Hey, sorry, you’re not there yet. You’re not bad enough yet. You’re not sick enough yet. We can’t do anything until you get to this point, like with thyroid, you know, your thyroid is not destroyed enough where we’re gonna put you on this drug or we’re going to cut your thyroid out. So just keep living as if you’re living now, once you’re bad enough, then call us back and we’ll cut your thyroid out or we’ll cut out your colon. If it’s diverticulitis. We’re going to wait until you’re in really bad shape. We’ll go ahead and do surgery. Let’s cut a foot of your intestines out. Yay. No, that’s not the answer.

Dr. Justin Marchegiani: Exactly. And then just to kind of echo on it because we see a lot of H. pylori, and conventional medicine may do a endoscopy for that where they’re taking a sample in the upper intestinal tract view the scope, they may do a stool And that may or may not pick it up. And then they’ll typically do the breath testing and like there’s different kinds of breath testing, as I already alluded, right you have your lactulose, which is going to be more your cebo breath tests, it’ll look at hydrogen and methane. You have your glucose, which may look at upper intestinal, upper gut, stomach type of bacterial overgrowth, right lactose takes about two hours to work through the full stomach, the small intestine, so anything after two hours is usually a pretty good window into the colon, because that’s where lactose starts to get absorbed by the bigger, bigger bacteria in the colon. But glucose tends to get absorbed a lot faster in that first, you know, 20 to 40 minutes so it gives you a better window of the stomach. And then you have your h pylori breath test where they’re giving you like it’s a urea breath test, they’re giving you like a urea tablet or a urea solution. And basically, the H pylori in your stomach will take their urea, right because typically how h pylori works, that makes an enzyme called urease. And that method analyzes the urea and the protein into ammonia and co2. So when you give that urea, the H pylori will convert a lot of it into co2 and ammonia. Ammonia has a pH of 11. So it’s very alkaline so that throws off your stomach digestion and lowers your stomach acid, but it also spits off a lot more co2 than in their mess. They’re they’re measuring high amounts of co2 to get a window if you’re positive for H. pylori on that conventional H. pylori breath test. So they’re looking at three things. Typically, they’re looking at breath, maybe a stool antigen, which is the stool under a microscope, they’re looking at maybe an endoscopy, if it’s more serious to rule out gastritis or ulcers, and then maybe a blood test with a look at like an IGG, IGM, or IGA. And it G’s more of a long term marker, so you really want to request an IGM IGA to see if it’s more active and acute. So those are the big things that they’re going to be looking at on the H. pylori side and I just say that because h pylori is a big thing. We find a lot and can be a problem in a large percent of the population after 30 to 50%. And then I would say things like Candida or a fungal overgrowth are very rarely looked at or assessed and will typically look for that in the stool. And we’ll also look for that in the urine via a functional DRAM and a tough test. So we’ll look at things with a good functional stool assessment. We’ll also maybe do that cebo breath test that lactulose SIBO breath test. Now most conventional gi Doc’s don’t do it. There are some like for thinking conventional MDS that are gastro docs, like Dr. Pimentel at a cedar Sinai, he started making more of the breath testing more mainstream on the conventional side, which is good, which is excellent. But still, a lot of conventional Doc’s aren’t even doing it. So we’ll do that. We’ll look at it we’ll run the more progressive sensitive DNA stool tests. And that will also look at the urine test which can look at bacteria in the urine and it can also So look at fungus in the urine, the [inaudible] or I can look at the hippo rate and the indicator which is a marker for bacterial overgrowth, as well as protein putrefaction not breaking down your protein. So benzoates another big one. [inaudible] in a tick is the fungus. And those are HIPAA raised another big one, there’s a couple of 2 phenylacetic acids. Another big one is about 10 markers that we’ll look at for bacterial overgrowth on an organic acid.

Evan Brand: And none of the stuff that we’re going to do is going to be invasive at all we’re going to get into kind of the, you know, compare and contrast some of the treatment options to we have regarding the testing the stool that we’re going to do, it’s an at home stool test, it’s going to be way more accurate. I’d like to put a number on it and say 100 times more accurate and sensitive but I don’t know the exact number. I would just say that. We’ve had hundreds and hundreds of people who’ve done conventional testing through their practitioners, they show up with nothing, even like doctors data has missed in fact For example, but there’s DNA stuff that will run will find or fill in the gaps where the other testing failed or lacked. So that’s going to be the at home stool testing, and then the organic acids testing. That’s amazing. I mean, that even find stuff that the stool test doesn’t find like the yeast overgrowth, and it’s all done at your house. It’s amazing. Nice.

Dr. Justin Marchegiani: Yeah, it’s very, very nice. It’s non invasive. I’ll tell you the problem with a lot of conventional medical assessment, if they’re doing a breath test, fine. If they’re, you know, obviously a good pal patient is really nice, especially when it’s acute, conventional medicines really good at finding Irritable Bowel Disease, like you know, krones ulcerative colitis, or something more like an ulceration. If you’re older that can be helpful at like precancerous polyps, but even that they don’t address why those polyps grow. That’s another conversation. So they’re really good at finding those kinds of things. But the question is, how do we get there is that underlying cause being addressed a lot of times it’s not, and then a lot of times it’s being managed with ppis proton pump inhibitor. Maybe a corticosteroids, some kind of like they have like natural coating products that kind of coat the gut but still don’t fix the underlying issue. May maybe Imodium or some kind of antispasmodic, or anti nausea medication, especially when IBS is a diagnosis because a lot of IBS type of diagnoses or diagnosis of exclusion, meaning they’ve ruled everything out, therefore, they give you this diagnosis, which means, hey, you have some symptoms, but we have no idea why it’s cost or what the causes so they give you this diagnosis, you feel comfortable that you got a label, but that diagnosis is a diagnosis of exclusion. It’s you rule these things out, therefore it has to be this that tells you nothing about the underlying cause. And you’re still recommended just certain medications that control the symptoms, and may create more problems over time. Like if you’re on chronic acid blockers, you’re going to have issues with minerals, and digesting protein and digesting fats and over time, you can have some serious nutrient deficiencies for sure.

Evan Brand: And then you can have mood issues, you’re gonna have sleep issues, because now you’re not making neurotransmitters from the amino acids. So now you’re irritable, you’re anxious, you’re depressed, you can’t sleep at night, and your guts still a wreck. And that was me. And I got the diagnosis of IBS and it was nothing but drugs. And back to my friend’s wife. So they recommended that we talk about that probiotic. It was just one strain, and it had a bunch of garbage fillers in it. They also, of course, told her to eat more fiber. And this is a woman who’s basically pescatarian and she’s eating cooked organic vegetables for almost every meal, I’m like, wow. So they told you eat more fiber? Did they even ask you about your diet? No, of course they didn’t. They didn’t ask you what you’re eating. I mean, vets are better at helping with gut issues. And dogs then gi dogs aren’t helping with gi issues in humans. Why? Well, because the first thing you do when you go into the vet, what’s the vet gonna say? Oh, what kind of food are you feeding him? You go and you take your puppy and oh, my puppies, you know got diarrhea. Oh, what are you feeding your puppy? But that’s not the first question that gi doc asked. Now It’s not the first question we asked either right boy definitely in our it’s definitely in our workup.

Dr. Justin Marchegiani: Oh it’s something that’s going to be going to be asked on day one is one of the most important things for sure. But kind of getting back to the conventional Sykes I really want to give conventional medicine it’s Do you know hat tip where it’s good, it’s really good at a lot of these conventional, you know, irritable bowel diseases or extreme ulceration, they’re just still not good at getting to the underlying issue. So let’s say you have an Irritable Bowel Disease, right? They may give you something like a lialda or mesalamine or a corticosteroid or a biologic or an immunosuppressant or some type of antispasmodic or Imodium just something to manage those symptoms. If it’s bad enough, they may give you chemotherapy like a methotrexate, something like that. They may do deeper testing like a CT scan, if they’re looking at things or a MRI, which doesn’t have the radiation CT has the radiation they made. They made a deeper testing for that. A lot of times they’re still going to want to go inside Do that colonoscopy or endoscopy for sure, which has its own host of issues because you typically have to be under anesthesia for those, okay? And anesthesia has a major negative impact on your gut flora. And sometimes they may even want you to be on antibiotics post treatment sometimes. So it just depends upon the doctor and kind of your situation. But the anesthesia could have some negative impacts on it. And there’s some data it’s more controversial now, but I’ll put it out there. But there’s some data talking about the fact that the equipment that is used to do a colonoscopy, the cameras or endoscopy cannot fully get sanitized due to the sensitivity of the equipment. It can’t fully get sanitized. Therefore, there could be some potential fecal debris on there. from a previous patient. It’s possible right? It’s more controversial.

Evan Brand: No, I don’t think it’s controversial. I’ve seen it for years man, they call them  HAI- hospital acquired infection. It’s huge. It’s one of the leading causes of death in hospital setting is an infection that you pick up by getting a routine procedure done. I actually had a woman who had this happen, and she developed major, major major c diff infection. So she had issues before. You know, she was having a lot of stomach pain, a lot of burning. She went in, went to the gastro, they did the endoscopic, the endoscopy, and let’s go. And after she got home, she had endless, endless, almost to the point where it killed her diarrhea. And I was like, oh, that doesn’t sound good. And guess what she had Clostridium difficile, also known as C diff. So then what happened? She gets the conventional GI Doc’s to prescribe her antibiotics, very, very strong antibiotics. However, C diff is just one of the major bacterial infections that’s become resistant to the antibiotics. The CDC has been warning this about this for years. They now call what we’re in now is the post antibiotic era. Just look up CDC post antibiotic era, you can read about it. And so this woman still had seed if she did the antibiotics, she killed off any remaining good bacteria. And she was still miserable. We ran the testing on her confirmed the C. diff was there via urine and stool. And then we used anti microbial herbs. And guess what, we got the woman better. We got the C. diff gone, and she was fine. So I’m glad that you pointed out they are good at finding stuff. That’s pathological. But yeah, and then they’re not going to tell you why you have Crohn’s and they’re not going to put you on an autoimmune Paleo Diet like we are.

Dr. Justin Marchegiani: Exactly, they’re not going to do that. Now, just to kind of highlight a couple things here. We talked about the hospital acquired infection, there’s also a chance of, you know, rupture, or, you know, poking the hole with with the cameras that are going into your, into your throat or into your rectum as well. It’s always a possibility. So the nice thing about some of these, the assessment and testing that we do, there’s no chance of any side effects, which is excellent and there’s no chance of disrupting your floor either with anesthesia or swallowing radioactive solution, right? So it’s nice to have an assessment that doesn’t really have a chance of causing any more problems. And it gives you that full spectrum because remember, on the conventional medicine side unless there’s this much inflammation on the scale, here’s optimal. Here’s a diagnose visible condition. There’s a large gap here. And if you’re somewhere in this gray area, this is the gray area where the doctor says, Hey, we can’t help you. Hey, it’s all in your head, hey, you’re just getting older. Here’s a prescription for an antidepressant. Like literally, these are things that happen after the fact and there are some doctors that are saying, Oh, well, here’s a probiotic, like you mentioned with your friend that called you and they recommended a crappy antibiotic right now. Hey, that’s better than jumping on the anti depressant, right? That’s at least a good step in the right direction. I appreciate the thought right A for effort, but outcome Not quite. And so the people are starting to wake up a little bit and I think people are under doctors are understanding that patients are going above and beyond and they’re reaching out the doctors like so some not a lot are striking. Trying to get through games stepped up for sure.

Evan Brand: Yeah. And the other story I had in my head, I may have mentioned this for but a male client of mine, he went in and got an endoscopy. And I don’t know exactly what part what material, what piece of the equipment, but anyway, he has a piece of equipment stuck in his body. And he has to go, he has to go in for surgery now to get that piece of equipment removed. And he just went in for a routine scan into scope. And now he’s got something stuck inside of him. And now they got to cut them open and get it out versus we’re having you wake up and pee in a cup at your house and mail it to a lab and we’re getting hundreds of biomarkers from that. And we’re having you poop into a tray and you scoop that into the collection to and you’re also doing that at home. And you’re sending that into the lab. So I mean, just in terms of ease, and you know, I’ve we’ve talked with quite a lot of few people who they’re worried about their immune system, so they don’t want to go around the hospital anyway, where there may be people that they could get exposed to COVID Yeah, so We’re saying, Look, don’t worry, you’ve never had to go anywhere. And with our practice, you still don’t have to go anywhere. And we’ll still mail you everything. You don’t even have to go to a pharmacy yet to pick it up. We’re going to mail you what you need to your door. So that’s fun, more convenient for sure.

Dr. Justin Marchegiani: Love it. But we did a pretty good job. Now we’ll just kind of compare and contrast a lot of the treatments, right? Because I have my six our protocol on how we work on digests or work on supporting someone’s health. So of course, gastroenterologist are typically going to make zero recommendations on food. Now some of the more progressive ones may say, hey, cut out gluten dairy, refined sugar, that that could be common that a lot of times, that’s not going to be enough, or they’ll recommend a conventional low fodmap diet, which could still have other grains and other inflammatory foods in it. So that still may not be great. So we have kind of our own special kinds of diets that we use, whether it’s a specific carbohydrate diet, cutting out females, salicylates, whether it’s not immune diet, which is kind of paleo plus, right, paleo. No grains legumes dairy right on the immunes no nuts seeds nightshades eggs we may do a keto we may do a carnivore we may look at cutting out histamines and a lot of different dietary templates that we have used thousands of times and we kind of know where the best ones to apply are, that’s important because nine times out of 10 your conventional doc won’t even touch that. Okay, next up is we’re going to recommend digestive support. Now your conventional Doc’s more likely to prescribe an acid blocker than anything to help improve digestion. Now, an acid blocker may be reasonable if there’s an ulcer or an acute ulcer. Now, a lot of times also like pain can improve with digestive support. So there’s also like pain we make ask to try a tiny bit of acid, the tiniest amount, maybe a teaspoon, or an eighth of a teaspoon of ACV or lemon juice. If that causes any irritation. We can all assets we just lean on enzymes. We just lean on maybe some bile salts and then we work on adding in extra healing and soothing nutrients to help support the gut lining conventional Medicine are not going to recommend any healing soothing nutrients, they’re not going to recommend glutamine, aloe, dgl, zinc, rising carnosine, they’re not going to recommend any of these high quality nutrients to help support the Go on.

Evan Brand: Let me point out to if you’re putting anything with acid on the shelf, it’s on the shelf temporarily, we’re likely going to bring that in at a future date where, you know, I got into the debate with the GI doc back in the day, and I asked her, Well, why do I feel better when I do extra acid and extra enzyme? She goes, No, that’s not possible. I’m like, I take more stomach acid, the more stomach acid I take, I feel better. I have less bloating. I have less gut pain. Nope, that’s not possible.

Dr. Justin Marchegiani: Okay, that’s someone that does not have an understanding of physiology, right? Because physiology tells us the more stressed and inflamed we get, the more our sympathetic nervous system is activated. Where does that jump blood to? arms, fingers, feet, why run, fight flee. So all that goes away from the intestine so we have a decrease in our digestive juices and we have a decrease in acidity because that’s part of the juices that are produces and then the acidity triggers enzymes to be produced. So if you have any type of acid irritation, unless we’re coughing up blood, or we have an active Oh sir, I always recommend adding a very tiny bit because sometimes, least half the time, it can make it better. Sometimes the mucosa is so raw that it can’t handle it. So if that’s the case, if we can’t handle it, we lean more on enzymes and healing soothing nutrients. If we can’t handle it, then we just gently taper it up. And again, we’re typically recommending a stool test that’s going to look at old cold blood. So we’re going to get a really good window if there’s blood in the stool or run a conventional blood test that will look at red blood cell hemoglobin hematocrit and particular sites, okay, particular sites or young, immature red blood cells over losing a lot of blood. Guess what goes up particular site. So if we see a lot of particular sites that could be a sign of blood loss. Now, women could have that because they bleed a lot men straight Why’s and have a lot of estrogen dominance? So you have to understand the context of what you’re testing. And when.

Evan Brand: Yeah, good point, good point, the calprotectin we are going to be looking at so that is one marker that does have good overlap from conventional to the functional side. We love looking at calprotectin that’ll kind of give us a clue on just how inflamed is the gut? And is it possible that we could throw in a little bit of acid right away, and I’ve had people that they have had high calprotectin. And we were able to still do a low dose, maybe two to 400 milligrams of patane. And that was enough to really calm things down and improve their digestion so much that we then infer that the malabsorption was creating the inflammation in the first place. And all we did is help them break down their foods better and then the inflammation always drops. It’s so fun to see that I’m sure you get the same high from it that I do where you see high calprotectin you’re like well look at this number. It’s scary. We don’t like it. Yeah, protocol, retest boom, look at the levels drop. It’s so satisfying.

Dr. Justin Marchegiani: Yeah, I would also say a lot of the inflammation and the irritation that is in the inside. decimal track can be from poor digestion. So the food purifies it ferments, it runs cinephiles, it basically rots inside your intestines, and that creates his own host of acids that can be irritating. And sometimes taking a little bit of a digestive acid can decrease the rotting acids from the food. So that kind of thought process is a little bit of acid can decrease the production of more acids from the rotting of the food. And big big clinical pro write this down. I always recommend taking acid with food already in the stomach. People can have false positive ulceration symptoms with HCL by not taking their HCL with food and that’s protein and fat. So I always like protein and fat on the bottom of the tummy kind of coating it and then we’ll typically come in if we’re on the fence with a 16th to an eighth of a teaspoon of ACV or lemon juice, tiny bit and some water just a tiny bit and then that’s a good first step because if you can handle that, then usually you can work your way up. If you can get to a teaspoon to a tablespoon, then usually we can start to add in supplemental HCL and go from there. But worst case, if we can’t, or we’re just being more conservative, we just lean more on enzymes. We go to the gut healing nutrients, and the third are repair right repairing the hormones and the gut healing nutrients where we support a lot of the adrenals. and stuff as well. We need testing for that. The fourth RS where we come in and knock out infections. Most people on the conventional side the antibiotic is prescribed first, not fourth. So we set the table so we can go in there and deal with infections better. And then we’re using herbs that have more of a broad spectrum, but I’m more selective for the bad critters versus the good guys, which don’t create as much of a rebound overgrowth, and then we deal with repopulate rynok good bacteria and we’re not doing just to defeat along them with a whole bunch of additives. We’re doing professional strength professional grade, high potency antibiotics that have you know, that the amount of probiotics on our labels is where that would be at expiration. Not at manufacturing. So when you get a product from us, you’re probably getting double the amount that’s actually on the bottle. And then six RS retesting, and we understand that siblings and their spouses may pass infections back and forth. That’s really important to keep that in mind when we have a chronic issue.

Evan Brand: Yeah, and that’s not that’s not going to get brought up ever. I mean, I actually had a actually had a medical doc send me an email, and they were mad at me because I blamed the husband’s H. pylori infection on the wife. And so the wife was working with this doc and was saying, this practitioner, this guy on the internet, is saying that I’m the reason that my husband got reinfected with h pylori. So the medical Doc’s like that’s not possible. That’s not true. I’m like, Look, man, I could send you hundreds of cases I’ve got before and afters here where we tested someone. We then made a protocol we got rid of the infection two to three months later the infection comes back within test the spouse, boom, the spouse is positive, then we put both Have them on a protocol, boom. Now both of them are clear and both of them stay clear. So, I mean, why that would be controversial? I don’t know. But it was it was a funny email.

Dr. Justin Marchegiani: Yeah, I mean, I have one study right here in front of me it’s called saliva secretions in the efficacy of H. pylori. They’re talking about H. pylori was detected in dental plaque and oral lesions and in the saliva.

Evan Brand: When was the year of that study? Just curious.

Dr. Justin Marchegiani: Yeah, I’ll pull it up here right now. So you can see it may put it right up on the screen-

Evan Brand: Because maybe, you know, maybe this was a guy who maybe he hasn’t looked at a journal in 20 years and he doesn’t know that this is possible or true. And while you’re doing that, too, I want to say something about the-

Dr. Justin Marchegiani: 2011 but there’s a lot of studies on this stuff. So there is going to be some h pylori in the saliva for sure.

Evan Brand: Yeah, and I want to talk about the the herbs in such too. So the cool thing is with the anti microbial herbs, those alone can help reduce them. inflammation and we made out of the gate, as opposed to saying, Hey, here’s an acid blocker out of the gate. If we’re waiting on testing, you know, if someone’s really miserable, it may be 2 3 4 weeks turnaround time. We could throw something in right out of the gate that’s going to address and calm things down, which is very, very good. We talked about a guy had that was a teenager with panchal itis we talked about him a few podcasts ago. But anyway, we got him started on a really potent aloe extract right away. And by the time we got his lab results, Two, Three weeks later, he was already significantly better in less pain, less misery. So that’s the cool thing is there are some quote like, I don’t want to call him urgent care, but for lack of a better term, there are some quick fixes that we can implement right away before we get testing.

Dr. Justin Marchegiani: Totally. And then right here, salivary secretions, the Journal of dental think this is out of two round salivary secretions and advocacy of H. pylori eradication. So basically, they see that hey, the oral cavity may be affected, right. And they see that there could be saliva. saliva could contain H pylori secretions and then the conclusion is they find that h pylori eradication from the stomach may reduce the may reduce the salivary secretion of H. pylori. So we see that in some of the studies and this has been around for a while, so, it’s good to know that and that just kind of supports our theory that we’ve seen clinically with spouses passing things back and forth. And, again, you know, it doesn’t have to be a sexual thing, just sharing drinks and maybe silverware and just living in a house where those kind of things happen easier, right? That increases the chance.

Evan Brand: Oh, yeah, we’ve seen it in kids where it’s like, oh, hey, honey tribe, I did this organic dairy free ice cream, and mom’s got h pylori here. She has given her two three year old the spoon and then you and I’ve seen you know, countless children 2 3 4 5 6 year old kids with H. pylori, and my daughter had it my oldest summer she had h polarized so we tested her gut she had parasites first we eradicated those then on the retest H. pylori showed up and then luckily we were able to get rid of that. So you know, we clinically and personally deal with these things all day, every day, so we have a lot of, we have a lot of sympathy and empathy when it comes to the gut work here. And I just feel for all those people like me that they go to the doctor’s, you have so much hope you’re so anxious about the appointment. I remember feeling comforted. I remember I was in so much pain. I remember being in that office waiting for the doctor to come in. And I just felt comforted back then being in that environment. I’m waiting in the office. I’m like, Yes, she’s going to come in here he or she’s going to come in here. They’re going to give me the answer. They’re going to help me they’re going to get me solved. And then my bubble just got burst. I remember walking out of that place just so disappointed. I thought, oh my god, I remember the beginning of my appointment here. I was so thrilled and happy. I’m going to get to the bottom of this thing. And then here I am, you know, X amount of time later so disappointed and had to keep searching. So we feel for you, we’ve been there.

Dr. Justin Marchegiani: 100% and then again, just because someone has h pylori. The healthier you are, the stronger your immune system, the better levels of IGA you used to create which is going to be in the saliva. mucosa mucosal membrane barriers that’s gonna fight these infections. So it’s just because you get exposed to it in the saliva doesn’t mean you’re necessarily going to get an infection. But the more immuno compromised, you are stressed, weaker adrenals gut barrier integrity issues, poor digestion, the greater chance that h pylori that’s in the saliva could gain a foothold in your body. It’s very possible.

Evan Brand: Yeah, good point. I’m glad you pointed that out. Because there’s going to be a couple haters. Eventually, they’re going to hear this and go, Oh, that’s bullcrap. You know, 50% of the population has H. pylori, you’re painting it to be the bad guy dead. Well, in the modern world, people are so toxic, so stressed, so immunocompromised that I don’t think we can coexist the way we used to, because our buckets are so full. So these things do tend to take on a more pathogenic pro inflammatory state than maybe previously where people stress bucket and toxin bucket was less full. So yeah, I’m glad you made that point.

Dr. Justin Marchegiani: Yeah, and again, not everyone will get exposed to it, because their immune system will just knock it out via their IGA and some may get it but they’re going to be able to be Ace symptomatic, and they’re okay. And then they’re just like, hey, this isn’t a problem. And then they project their their good health and their asymptomatic status to Hey, you know this, this can’t be the problem, because I had the same thing, but everyone has a different constitution. And because of that constitution difference, it could affect you differently. For sure.

Evan Brand: Yeah. Well said, Well, I think we did a good job. We covered the testing piece, kind of the conventional colonoscopy and endoscopy, barium X ray scans, MRIs, CAT scans, CT swallowing, radioactive tracers, compared to the at home, organic acids and genetic DNA based stool testing that we’re doing at home with people. We compared the drugs, the antibiotics, the acid blocking medications, the antispasmodics, the immune suppressant or immune modifiers, like you mentioned, possibly an extreme case a chemo drug, versus we’re going to be going for more inflammatory herbs, natural antimicrobial herbs, anti parasitic antifungals, possibly some extra acid and enzymes, maybe some zinc carnosine and other things to heal up the gut later. Maybe some additional mushrooms and adaptogenic herbs to strengthen the immune system, possibly using these things throughout the family with spouses or children to help protect them as well. And then of course, the diet piece possibly, like my dad when he was suffering. When I was a young kid and he was suffering with diverticulitis, he was told to eat more fiber and that was his diet protocol. And it was take you know, GMO Metamucil psyllium husk or whatever it was with natural with it probably wasn’t even natural flavoring back then it was probably artificial flavoring. And that was the protocol versus you mentioned the templates so possibly, low fodmap low histamine, paleo autoimmune carnivore. There’s different things that we’re going to do based on our educated guesses plus, with the labs, the information and then people’s food journals, how are they feeling basically-

Dr. Justin Marchegiani: Even cooking, cooking, a lot of times just cooking those foods up better, avoiding raw foods and that can help a lot right the cooking is pre digestion and if your tummy has a heart digesting the food The more we can pre digest that food within reason you know steamed sauteed even stews or soups instapot crockpot pressure cooker that can really help with helping the tummy access those nutrients better. 

Evan Brand: I brought out the Instant Pot The other day you know it’s summertime it’s hot so it’s not very attractive to bring out the Instant Pot but man, we threw some organic purple sweet potatoes in that instant pot, 10 minutes. It’s awesome. Oh my god, they were so good.

Dr. Justin Marchegiani: Oh, yeah. Like like my carb cheat on the weekend is going to be potatoes because why? Cuz they’re grain free. They’re starchy. I can handle them on the autoimmune side. Some may not be able to but it’s just it’s a really good healthy safe starts and it gives you that mouthfeel that you’d miss from like, you know, breads or grains. That’s my big cheat and I do 10 minutes on the instapot on that it’s wonderful or, you know, at a nice Steakhouse is pretty good too.

Evan Brand: It was hard to believe I could I mean, it was a pretty good sized potato and I thought 10 minutes there’s no way this thing’s going to be done. It was done. We put some butter on that bad boy, some garlic salt. Delicious. 

Dr. Justin Marchegiani: It takes 45 minutes to do Boiling or steaming in real life. I mean, the instapot is pretty amazing how fast they can cook stuff. 

Evan Brand: This episode is brought to you by Instant pot.

Dr. Justin Marchegian: I know right? Awesome well if you guys are enjoying this content and you wanna share with your family and friends, or you wanna dive in and get support from myself, Dr J or Evan,, reach out for Evan. reach out to myself, Dr. J. If you guys enjoy the content we’re available, click down below, whatever you’re source, we have links down below to get access. Make sure you give us a comment. Let us know what you think, what you like, what parts resonate with you, give us a comment, like, share, hit the bell for notifications and we appreciate you guys sharing this with your family and friends, so they can become empowered about their health. You guys have a phenomenal day. Take care ya’ll.

Evan Brand: Bye now.

Dr. Justin Marchegian: Bye.


Audio Podcast:


Mitochondrial Dysfunction & Other Causes of Chronic Fatigue- Mold & Candida Contribute | Podcast #287

Welcome to another episode of Beyond Wellness Podcast! For this episode, Dr. J and Evan Brand talk about chronic fatigue, which is a disorder characterized by extreme tiredness that doesn’t go away with rest. Because sometimes, chronic fatigue can also be associated with mold issues, Candida and etc. Check this podcast out. Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

1:06     Mitochondria

8:26    Toxins that damage Mitochondria

14:40   Mold Issues

22:22   How Mold and Candida affect Mitochondria

31:05   Nutrients and Vitamins

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Dr. Justin Marchegiani: And we are live. It’s Dr. J here in the house with Evan brand. Today we’re going to be chatting about chronic fatigue, mold issues and other different causes that could drive chronic fatigue. Evan, how are we doing today? 

Evan Brand: I’m doing really well. We’ve got just a couple of papers on this. And we don’t really more than that, because we have so much experience now ever since I had my issues. And you and I started digging into this. It’s like you and I jumped into the mold whirlwind over the past few years together. And it’s been really fun learning and educating people simultaneously. We’ve implemented stuff in our houses that have been game changers for us. We’ve implemented stuff clinically, that have been game changers for others, but I believe this is one of the biggest triggers of chronic fatigue is mycotoxins and I experienced it personally and so I can tell you my own issue, I was exhausted and I’m still recovering from that and your exercise intolerance goes down and a lot of that has to do with the mitochondrial damage to happen. So could you just give us maybe like mitochondria 101 What like, how do they help people? Why are they so important? What happens when they get damaged and all that? 

Dr. Justin Marchegiani: Yeah, so your mitochondria, they exist inside of yourself, okay? And it’s going to generate ATP. And part of you know, so you have glycolysis, right? That’s going to be outside the cell where you’re kind of taking glucose generating energy. And then you have the Krebs cycle where you’re spitting out different amounts of hydrogen and ATP. And those hydrogens then now go into so you have these things called reducing agents, called FADHNAD and they gather up hydrogens, okay? And then these hydrogens, right, they enter the electron transport chain, they generate more ATP. So you have glycolysis to the Krebs cycle, right, or citric acid cycle, same thing. And then we have from there into the electron transport chain. And this is where we start to enter the mitochondria. And we need things like carnitine to help shuttle fat into the mitochondria. We need B1 B2 to help with fatty acid oxidation in the mitochondria, it’s part of how the mitochondria burns fuel to run the Krebs cycle and to get the electron transport chain set up we need B vitamins, we need magnesium we need carnitine like I already mentioned before, we need creatine we can use things like ribose we can use things like co q 10. These are all really really important nutrients that fuel these different metabolic pathways obviously, intermediary nutrients like Fumarate and malate and succinate. And then different amino acids are involved with the electron transport chain and or the citric acid cycle, Krebs cycle the leading up to it. So all of these pathways, they roll and they really help generate energy and generate ATP, which is that energetic fuel source. 

Evan Brand: And there’s a really good picture of the citric acid cycle some of the stuff that that you and I’ve learned from some of our books and study so we may be able to put that up in the shownotes to where people just want to download it look at it, I think it’s kind of cool because you could look at it and you could just quickly learn all the different nutrients that fuel each part of the cycle. So then I don’t want to say you could spot treat but for lack of a better word, you could kind of spot treat and go, Oh, magnesium, boom, I might be missing that be six. Oh, I might be missing that.

Dr. Justin Marchegiani: 100% Yep. 100%. I’m gonna try to pull up a good picture for everyone to see here. So they can kind of wrap their head around it. A picture’s worth 1000 words. So if you guys can kind of understand the concept. I think that makes it a lot easier. I’ll pull that up here in a minute. Okay. All right, cool. Anything else you wanted to highlight on that before we dive in a little bit more? 

Evan Brand: Well, you mentioned a bunch of different nutrients. And so I think the most important part to pay attention to is that today we’re focusing kind of zoomed in. But you mentioned a lot of stuff that people could be deficient in for other reasons that we might not cover today. So parasite infections, bacterial overgrowth, any kind of dysbiosis. That’s not allowing the gut bacteria to produce some of these nutrients that may be involved. But that’s not the highlight of the show today. Today we’re focusing on other triggers and other causes. 

Dr. Justin Marchegiani: 110%. Exactly. Very good. So of course, the first thing is we have things that enter the mitochondria. And that major nutrient, that major compound that’s going to enter that mitochondria is going to be acetyl co a, and acetyl. co a is made from fats, carbs and proteins. So the first thing I always tell people is we have to make sure we can digest and break down our fats, carbs and proteins. And we have to make sure we have good proteins, good fats, primarily carbohydrates. You know, of course, if you’re more active, you know, you can always do more safe starches and make sure you’re not doing too many grains and an inflammatory refined sugar. But we need good fats, we need good proteins because that performs and creates a really good building block for that acetyl. co a, and we need that for really, really, really good mitochondrial production. 

Evan Brand: Yep. Let’s dive into this study. This is really cool. One of my favorites, this guy, Dr. Brewer-

Dr. Justin Marchegiani: If you don’t mind, I want to just hit one more thing. Just I want to set the table a little bit more for the listeners. Okay, let me just do this here real quick. All right. This is a really, really good picture. Can you see that on my screen yet?

Evan Brand: Yep, there it is. 

Dr. Justin Marchegiani: Okay, good. This gives you a pretty good idea. So the mitochondria is kind of the powerhouse of the cell. All right. And so when you look at energy, we first have the cytosol that’s outside of the cell. This is glucose. Glucose comes in glycolysis means breaking down glucose. glyco means glucose. And then license means breaking down. So we generate a little bit of energy here, ATP from glycolysis. Okay, then that then that little bit of energy then moves into the mitochondria. So this is the mitochondria here right now. So we have acetylcholine, acetylcholine then starts going into the Krebs cycle, that Krebs cycles in a turn twice and it’s typically forget exactly, I think it’s two to three NADH or going to be spit out for one fa, d h2. And this is going to turn around twice. And then these different electrons, these hydrogens that are collected from the Krebs cycle, the NADH and the FA, d h 22 to 3, NADH, one fA d h two going to enter the electron transport chain, and then more ATP is then created. So I want to say it’s like 36 to 39 ATP are created from glucose to Krebs cycle to electron transport chain, and I want to say it’s two or three for glucose. Like Allah says two or three for the Krebs cycle, maybe six for the Krebs cycle. And the electron transport chain is the majority where it happens. I want to say 33 or so I want to say it’s about 36 to 39 total ATP, per this whole thing and this is a mitochondria right here. So all most of this stuff happens in the mitochondria and then some of it happens outside in the cytosol. 

Evan Brand: Yeah, that’s what I was going to ask you. So if someone has major mitochondrial issues according to this picture, it looks like you would still be able to generate some, but it’s going to be a minimal amount of ATP created from glycolysis. Is that true? 

Dr. Justin Marchegiani: Correct and then glycolysis is going to be dirty fuel right? So you’re going to get a lot more oxidative stress because of the advanced glycation end products that occur when you start making a lot of sugar right? A lot of sugar you coat your proteins right this increases oxidation oxidation and and then require more electrons to stabilize because when you when you oxidize something, right, think of cutting open an avocado, and it browns right or think about cutting open an apple and it browns, you’re losing electrons. That’s what’s happening there. Now you can easily go take a nice lemon or lime and squeeze the vitamin C from that on there, and that will prevent it from oxidizing. So the difference in your body is going to require a lot more antioxidant reserves. If you start creating a lot of oxidative stress, so glucose always burns dirty, okay, and there’s a really good book by Kristofferson called ‘Tripping Over the Truth’. And it’s a book all about mitochondria in glucose and cancer. So there’s a lot of data on this stuff already. So it’s really important to know that’s why we want to be more fat burners, good proteins and you can get carbs, you know, according to your metabolic needs. If you’re more active and, and you’re healthy, healthier and more fit and more lean and more active, then you can definitely add in some good high quality safe starches, but you really want to dial that in according to your metabolic needs. It’s not a set kind of size for everyone. 

Evan Brand: Very cool. Thanks for the picture. That’s awesome to see. So where do the toxins come into the picture? Well, the toxins are going to damage the mitochondria. So as you showed here, you can make some energy outside of the mitochondria. So you can still quote get by, but you may be exhausted if that Krebs cycle isn’t working properly due to potentially some of those nutrient deficiencies you covered that could be fueling the Krebs cycle. Maybe you’ve got infections or malabsorption issues going on. But we know that mold toxin damages the mitochondria law as well and actually sent you another paper in the notes if you wanted to look at it. It’s called mycotoxin its impact on gut health and microbiota. And this is pretty cool, because the end of this paper discusses that if you have good intestinal flora, they say here, it’s now well established that a healthy gut microbiota is largely responsible for the overall health of the host findings revealed that gut microbiota is capable of eliminating mycotoxin from the host naturally, provided that the host is healthy with a balance of good gut bugs. So long story short, and there’s a cool picture on that paper to just I don’t know if you can pull it up, but it’s called frontiers, cellular infection, microbiology, it’s a really cool picture of the gut and it just shows on the right that you’ve got all these different infections, like helicobacter, you’ve got E. coli, you’ve got reduction of beneficial bacteria, and therefore, the mycotoxins are not going to get treated as they should. 

Dr. Justin Marchegiani: Oh, I see that right here. Yep. So on that you see a whole lot bunch of decrease in good beneficial bacteria. I can share it right real quick here with y’all. You can see a decrease in a lot of your beneficial floor right here, man, you don’t see an increase in a lot of the pathogenic floor right here. And then of course, you have lipid polysaccharides. These are going to be your endotoxin that are the outer coating of the bad Gram negative bacteria. And then of course, you have more than mycotoxins. And of course, that’s going to stress out the microbiome stress out the immune system is going to increase gut permeability. The more gut more your gut is permeable, aka leaky gut, the more immune stress you’re going to have, because now your immune system is interacting with compounds and toxins that normally wouldn’t Is that correct? 

Evan Brand: Yep, that makes perfect sense. And this makes sense of why probiotics can be beneficial right out of the gate. A lot of people discuss and you and I discussed binders and Bluetooth ion and fixing the environment and all of that, but I mean, this shows here that bumping up your good bacteria is going to be a critical component to so I personally implemented a 50 to 100 billion have some multi stream probiotics and I have felt better. Is that the magic here? No, I’m doing a lot of things, but it has been pretty beneficial.

Dr. Justin Marchegiani: 100% Yep, pull up that pull up that Brewer paper. Now I think that’s going to be the next thing we should talk about. So let’s go over that. 

Evan Brand: This is crazy. This is crazy. So if you scroll down, long story short, in clinic, Brewer and some of his associates in this in this paper, they were testing using urine testing, which is what Justin and I run in clinic as well. We do a urine mycotoxin screen. And right here on the first page. It’s crazy says right here that urine specimens showed that 93% of his chronic fatigue patients these are known chronic fatigue sufferers. 93% of those were positive for at least one mycotoxin

Dr. Justin Marchegiani: Correct. So if you look here, right, here’s 112 patients 93% had at least one mycotoxin, again you have different mycotoxins, you have the aflatoxin- This is common like peanut stuff okra toxin and then you have the tri coat the scenes which is common in the in the black mold the Stacie buttress black mold, okay, so these different toxins we can actually test and now it’s important. Some people may test these things and they don’t do a really good glute. If I don’t push people that have really poor to toxification they may not push these things out. So you really want to make sure a couple of days ahead of time you do a good Bluetooth ion push and and even that you may just want to even look at the home too and do a really good play test on your home. Again, we use immunologic labs, we’ll put some links down below if you guys want to procure those tests, but some people they may have a hard time pushing it out. So yeah, so number one is I always recommend do a glutathione push. If you feel achy or really bad or brain foggy or tired or fatigued that could be a good time. Also, if you have a lot of mold in the home, especially molds that have these mycotoxins The nice thing about the amino Linux. It’ll tell you if these mycotoxins are produced by the species of mold they find so they see Aspergillus, or different mold that can be produced during water damage, then usually there’s an oak, there’s usually going to be a mycotoxin attached to it. There are some molds that are natural, like in soil and just plant degradation outside. Those are different some more from pet dander and those kind of things. So you’re able to get a window into all those things, as well. 

Evan Brand: Yeah, and I just want to say one comment about the push. When I first did my original mycotoxin urine screen, I did do Bluetooth ion for maybe three days and I guess that wasn’t enough because my Michael phenolic acid, which is a mycotoxin that comes from Penicillium, which I was exposed to my level was a 12, which was in the red range, but it was just barely. And then when I retested six months later after trying really hard and doing sauna therapy, which is another way you could actually do provocation. If someone doesn’t have glue defi on, you could do a sauna session, then collect urine, that could also help but six months later, my levels went from a 12 to a 1700 my levels were off the chart, even though I’d been trying for six months to get it out, and I did feel better. Some may look at that. And I’ve had some clients, you know, call me and they’re like, I’m crying. I’m freaking out, my levels went up what’s going on, and we explain most of the time, that doesn’t mean new exposures happen. That just means you’re getting better at detoxification, and you’re pushing more out. And that’s what happened to me. So my levels were really, really low. Six months later, they were really, really high. And then another six, eight months later, they were low again, indicating that I did actually detox it and push it out.

Dr. Justin Marchegiani: Exactly. Now part of the reason why we were able to stick with it is because we knew that you had high levels of mold in your old home, correct? 

Evan Brand: Well, so it was a crawlspace exposure. Looking back at the plates. The house was minimally bad honestly, what I think happened based on talking to Scott force grant, he his theory on it is that my tick bites that I got sort of set the mold in motion because I had the most exposure when I was a kid hanging out in my grandmother’s house. Were her babies basement flooded many times. And I remember going down there and smelling musty basement. So I guarantee you, I’ve had mold toxin, you know, just because I’m genetically unable to detox it like a lot of people are, I probably had it since I was a very, very young child. But his theory was that the tick bites basically weaken the immune system enough to allow the mycotoxins to really take me down. Whereas before, I may have had some symptoms, but it wasn’t as it wasn’t as brutal. So it was the combination of tick bites, and then some more recent mold exposure, that kind of retriggered things. Yeah, and I think it was just the straw that broke the camel’s back. I think it was a combination because I didn’t really get exposed to that much upon looking back at my plates and comparing those to some of my clients. I’m like, you know what, this wasn’t that bad. I mean, we had a though, I remember them being more high. So everything in the house was in single digits. It was just the crawlspace that was in double digits. And then once we did the fog treatment, everything was back to normal but what really screwed me is when we modified the the hva system. And we were trying to circulate the air in the crawlspace. Better. So the ductwork was changed to make a complete loop system from the crawlspace, sucking that air pumping that air into the house, and then the house pumping back in. So it was a continuous loop. And that’s what really screwed me because that setup wasn’t there before. And that’s what really cranked the levels up. And that’s where, even after we did an initial treatment, the levels went way up. Because now we were bringing in bad air into the breathable air. And so once we reverse that correctly, so if I remember correctly, is you had this crawlspace right, there was mold in the crawlspace. That was really high. The rest of the house was okay, but there was a lot of whole mold in the crawlspace they fixed the ventilation part of the home before they treated the crawlspace. Is that correct? Yeah. So we Yeah, we treated the home silly. I mean, absolutely. I can’t believe that happened. I’m just like, How the heck did these guys screw that up? I know, I know. So So then we treated it again though. And then the reverse the duck system that we had put in we reversed all of that. And then treated it again. And then it was fine. So technically, I could have stayed because the plates were incredible after that, but I needed a bigger house. Anyway, we had another kid come in. So it was a good excuse for me to just say, hey, let’s just go ahead and leave. 

Dr. Justin Marchegiani: Right but that was a big trigger for you. And then I think even in the new home that was still a little bit more mold that came back on that home to right near the retreat that address. 

Evan Brand: Yeah, yeah, we treated this house as well. We had some high colonies near the kitchen, which is potentially from the kitchen empties out into a screen room. So if those screen doors were always open, bringing bringing in outside air outdoor molds over time can accumulate in the house and make mycotoxins so yeah, we’ve we’ve treated it and now we just do some of the maintenance solution and we do some of the candles and such and now we’ve got it under control. So and then-

Dr. Justin Marchegiani: Also in general, you have the dehumidifier put in so then the humidity is now a lot less in the home. So that helps so there’s less breeding ground for it. And then you also just have air filtration throughout the home. So even if things were to come in your filters would naturally grab it anyway. 

Evan Brand: Yeah, I would assume my house is probably one of the few in Kentucky that doesn’t have mold in it because even with our whole house dehumidifiers, I mean, it’s pouring rain as we speak right now the ground rarely dries out because we have so much rain here lately. And even with the whole house dehumidifiers running, we’re barely keeping the house at 50% 45 to 50% humidity if you didn’t have those Running Man, who knows outside right now is like 86% humidity. And you and I’ve discussed this many times on the podcast, but you know, if you have humidity levels above 50% continuously in your home, you don’t have to have a water event. You don’t have to have a dishwasher overflow or a toilet leaking. Just the high moisture from the humidity alone can create mold, and that’s what happens in many homes that you and I’ve tested. 

Dr. Justin Marchegiani: Yeah, it really happens in areas where the temperature is just a little bit low. So you don’t have the AC because the AC will act with a natural dehumidifier but it’s temperature driven where humidifier is humidity percent driven. So I had a little bit of so if you have a you know 65 or 70, and it’s not quite triggering the AC, that’s where you really get screwed, but it’s not cold enough, not hot enough to trigger an AC but it’s also very humid 6065 70 or it’s just a basement area where basements are really cool but humid, that’s where you really need it because then if you get a humid basement, that’s cool. Well guess what it’s going to that ventually those molds are going to go upstairs to the rest of the home even if the rest of the home is is you know nice in and low humidity because of the air conditioner. So having a dehumidifier is important. I had a little bit of water issues over the weekend I was changing my water filter. And there was like three vowels you have to turn off. I only turned off two out of the three so it leaked a bit. Nothing bad I you know, got three or four towels cleaned it up. But what I did is I went in crank that dehumidifier down to 40%. And within two, three hours, any residual water that was hanging out was all evaporated, gone. But if you had 60% humidity in that basement, that water would just sit there for days on end. Once that water sits for 48 hours. It’s gonna start raining mold toxins. 

Evan Brand: Yeah, I’m glad you got the dehumidifier too. That’s, that’s pretty much essential for where we live with higher humidity. So, back to the chronic fatigue thing. So let’s keep going back on this paper because this is what I had.

Dr. Justin Marchegiani: If you want you can go share your screen here, Evan, you can share your screen if you like. Evan, are you there? Can you hear me? I lost that and guy, so I’ll wait for him to kind of come back on here. I’ll just keep on riffing. While we are waiting for him. I’m just gonna give him a message here.

All right, awesome. So just chatting with Evan here on the on the side here. He’ll be back on the show in just a minute. Let me keep rolling with you guys. So in general, we have the mitochondria we have different mold toxins that can affect and poison the mitochondria. One of the things that we get with fungus or mold is we get things called oxalates. And oxalates can enter the mitochondria enter the Krebs cycle, and make it harder for that Krebs cycle to work and harder to generate energy. So of course, that’s going to be a big component to stressing out the mitochondria. So when we look at molds coming into the end environment, whether it’s mold from outdoors, whether it’s molds or fungal because it kind of have molds, right, and then you have different things like funguses in your gut like Candida, they kind of have a similar mechanism where they’re going to affect and poison the mitochondria. and different things like that can create oxalate and they can really make it harder for the mitochondria to generate ATP. 

I’m going to show a couple of articles here I got an article on mold and how it can affect or Candida and how it can affect the mitochondria. I’m gonna pull this up with you guys here right now so you guys can see it. So this is interesting right here, you guys can see my screen chronic intestinal candidiasis as a possible ecological factor in chronic fatigue syndrome. We talked about Candida syndrome, also known as Candida related complex, putatively caused by an overgrowth of Candida, so that’s an overgrowth, not the Candida is not ever going to be there. It should be there and maybe at very low levels, it’s the significant overgrowth. That’s the problem.

And essentially in response of large number of patient with chronic fatigue to an oral antifungal agent, there’s evidence that Candida infection of the mucous membranes depress our T cells and natural killer cells. Similar abnormalities of the immune function are found in chronic fatigue. So it’s altering our immune function. So our body’s ability to deal with an immune response and deal with infections and deal with stress is going to be impaired big time. This is this is really, really, really important to kind of highlight and then it says, um, and it’s important in preventing reactions like epstein barr cytomegalovirus, herpes virus, there are other viral infections that could play a role with chronic fatigue. Right? And again, with chronic fatigue, the question is what comes first? Is it the chicken or the egg? In other words, when you have a an infection, is it the infection is cause is the underlying cause or did you have a weakened immune system leading up to the infection that caused the problem to begin with. 

That’s really what the underlying issue is, did you get the infection first? Or did the infection come as a result of the weakened immune system, and I’m not sure if it matters too much, we always try to line up what the what the likely causes. But we know here things like Candida and gut issues can affect the T cell and the natural killer cell, this is going to be our th one branch of the immune system. So our th one or those kind of special forces, they get in there and really do a lot of killing ahead of time. And they kind of the first line defense of the immune response. That’s like kind of really, really, really important to highlight and then it talks about here. And so then when you have a compromised immune system, other parasites other viral issues may be an issue then mold may be more of a problem. So now when you get exposed to mold, you may have been able to whip through it no problem you adapted to a bun now it’s like dang I think really knocked on your butt. So then said yes. The immune dysfunction found in the sorter has been considered the primary underlying cause. So this imbalance of cytotoxic T cell and T helper cells and natural killer cells is the underlying cause. It proposed that the chronic intestinal combat is maybe an agent, which leads to the immune depression in many chronic fatigue patients, and therefore, it could be a causal factor in chronic fatigue. So a lot of times we have the guts stuff leads the way. Okay, the guts stuff leads the way and then everything else happens after that, that makes sense. All right, excellent. Excellent. Very good.

I’m going to just take a pause here for one second. We lost Evan here, so I’m gonna see if I can get him back on the show as we chat. All right, let’s keep on rolling. So we talked about some of the guts stuff now you can see some of these things here with Candida and mold. We can see the same thing with CBOE as well. All right, if we look at small intestinal bacterial overgrowth, SIBO and chronic fatigue, guess what we’re gonna see similar things and why? Why is it? Well, it’s because of the fact that the God is where 80% of the immune system lives this is important. So when you look at research, research suggests the high prevalence of SIBO among chronic fatigue patients, One study found 77% of chronic fatigue. patients had SIBO why because when you start to have gut issues, the immune system starts to get revved up, right. And when the immune system gets revved up, it gets weakened or you start to create an imbalance like that th one part of the immune system starts to become depleted. And when that th one becomes depleted, that’s going to make it harder for you to go after and deal with other stressors like SIBO like Candida like mold, right. This is why the gods plays a big role is because you have this tube.

That’s technically outside of your body yet when you swallow food, it’s technically outside of your body because when it goes into the bloodstream, that’s now inside, technically, it’s outside of the body, you’re have 80% of the immune cells in the golf, the gastric associated lymphoid tissue, that’s the part of the stomach. And then we have the mall. That’s the mucus associated lymphoid tissue that’s in the in the small intestine. And if you have stressors, whether it’s bugs or bad food that stresses out the immune system, the more chronically the immune system is stressed. It creates imbalances and makes it so other things that now encounter your body like mold or Candida or viruses like epstein barr mano, right? The kissing disease. Now that’s going to create more stress and really, really, really knock on your butt. So we always have to look at what the underlying root cause of everything is. So, so we don’t lose sight of that. So we always want to understand what’s the root cause? What are associated causes and just because it’s an associative cause, you still want to make sure you fix it. Because sometimesyou’re not really sure if there’s three or four different infection 234 different bugs, does it mean that hey, each one is 25% equal, maybe, sometimes one’s a bigger one. And we also have to make sure we set the table. So if there’s food or other issues that are driving the problem, to begin, we got to make sure we fix that. What if those things have created an autoimmune issue? And now you have Hashimoto is because of the mold or because of the bug issue. Right. And now, the thyroids been attacked for a decade. Well, now what do you got to do? You can’t just ignore the thyroid and be puritanical and say, well, the root cause is Candida. 

Therefore, if I only fix the root cause, then everything else should be fixed. No, you may still have to go in there and support the thyroid because the hormone levels have now dropped, or the adrenal levels now have dropped. So you, you, you know, it’s easy to be like, well, the root causes this, everything else goes downstream, yes, but you may have to come in there and support those other pathways so you can get better and feel better faster. If not, you may be suffering for a long time. Really, really, really important points. All right, I’m going to roll with questions guys and see where you’re at with everything. So in general, with foods, big things that are going to stress this out, if you’re eating lots of refined sugar, and you’re and you’re spitting out a lot of candy to the candy doesn’t make a whole bunch of lactic acid, and that can make it and though that can easily eat a lot of your B vitamins, so the more Candida and the more bugs we have, the more you’re going to be consuming and ripping up a lot of your B vitamins. So B vitamins are very important. When you have bad bacteria, it’s gonna make it a lot harder for you to consume a lot of those good healthy B vitamins because your bugs in your gut are going to be consuming it for you. That’s like super, super important bugs in your gut are going to be consuming it. Number two is the bacteria is and it produced toxins. And this is big because these toxins now put more stress on your guts. So put more stress on your detoxification pathway. 

So when you have a lot more gut toxins, like polysaccharide or endotoxin, or the different mycotoxins may be made by Candida, and now your detoxification pathways get stressed. And now the sulfur that your body needs to run detoxification pathway have to get up regulated, you’re going to need more B vitamins like b 12, and fold a and be sick. So you’re going to need more of those nutrients as well to run those detoxification pathways. And so that can also drive fatigue as well because if you’re really like your body only has so many so much resources, so if you’re really toxic, if you’re really toxic, your body’s gonna allocate a lot of the nutrients on the B vitamins side or the sulfur side that may plug into the mitochondria. ….. ossification have less resources over here. So just just very, very, very, very important to keep that in the back of your head. Okay, awesome. Okay, very, very good.

All right, excellent. So it’s very, very important to really keep an eye on all the resources here because the more stressed your detoxification pathways gets, they’re going to pull a lot of that sulfur, they’re going to pull a lot of the B vitamins, and those are all nutrients that would plug into that mitochondrial pathway to begin with. So really, really, really, really important. You need so for people forget you need sulfur to actually make a lot of your dopamine and adrenaline. So dopamine and adrenaline. You need good sulfur. All right. And so if you if you’re chronically stressed, you’re going to be making a lot of adrenalin and eventually you’re going to be depleted because you’re not going to have that good software to take dopamine to norepinephrine, epinephrine, so you deplete sulfur because when you have dope mean that’s your feel good neurotransmitter you feel good, helps you focus. It’s a good reward center neurotransmitter, and that will go downstream, the more stressed your app is epinephrine, norepinephrine, that’s basically adrenaline or catecholamines. And these things are going to get very, very depleted, the sulfur will, will get very, very depleted, the more you’re chronically stressed, and then you’ll have less sulfur. And then the less sulfur you have, you’re going to have less building blocks for glutathione for your methylation, for all your detoxification nutrients, so it really plugs in. You want to look at everything holistically, so it all makes sense. All right, wonderful. All right, guys. Hey, phenomenal chat with you. If you guys enjoy today’s podcast talking about Candida talking about mold and mycotoxins connecting it to the mitochondria connecting it to energy. These are all very, very important components and on how and why everything you know is vitally important, why it all connects. So in general, co q 10. Very important, you know, anywhere between 100 to 500 milligrams a day. B vitamins, you know, a good high quality B Complex especially if we see on an organic acid test more forming a glutamate or more methylmalonic acid that tells us B12. And it also tells us full later benign, we may see things like xanthi urinator, kind of urinate which tell us B6 is important because B6 helps with our brain it is needed for the synthesis of neurotransmitters, right serotonin and dopamine. So if we don’t have good neurotransmitters that’s gonna really really affect our body’s ability to sleep to deal with stress mood, our adrenals right B five is a really important one pens authentic acid, we need it for our adrenals and also plugged into our mitochondria. Krebs cycle amino acids like I’ll see on these mitochondrial tests, we’ll see low sulfur like we’ll see low sulfate or low power of glutamate, or we’ll see low Pokorny, which is a sign of lower amino acids and these amino acids plug in to the Krebs cycle. 

And you can see here I’ll try to pull it up on screen how the amino acids plug in, but there’s a bunch of amino acids and the Krebs cycle. I’ll try to pull it up here. Now, why is this important? Well, because if you have poor digestion, because of mold, because of Candida, guess what’s going to happen to your body’s ability to break down protein? It’s going to drop, it’s going to significantly drop. Okay, I’m going to pull this up here so you guys can see how amino acids plug in. They plug in significantly. Okay, I got it right up here for you guys. Alright, cool. Let me just show this to you guys so you can see it. So this is what the Krebs cycle looks like. Okay, so you have remember this is the glucose here is in the site is all that’s outside of the mitochondria. Okay. All right, and then this stuff here comes in glucose phospholipids animal pyruvate pyruvate to acetylcholine. Now this starts to enter into the mitochondria, so sudo Coase now in the mitochondria, so look at these building blocks a Piru a to acetal koi look what it is people listening here we have a video version two so you guys can see my screen alanine cysteine glycine serine three Nene trip the fan right I so loosing all these things are big these are all essential amino acids that plug in to pyruvate and the seal co a and these kind of provide the building blocks to ratchet through your Krebs cycle and this thing is going to turn around twice. So you have saturate the ISO citrate and then you have alpha ketoglutarate more glutamine more prolene more histidine more origin and get plugged in. Then you have [inaudible] when you have more isoleucine more veiling right these are branched chain amino acids. Now this is part of the reason why working out with branched chain amino acids helpful refining 3d and then it goes from succinylcholine to succinate or we have tyrosine and phenyl alanine, which helps dopamine and adrenaline and then Fumarate to melee, melee to oxaloacetate, which is aspirin gene and aspartate. And then it plugs right back into we’ll see the code so you can see how that works. All right, you can see how that works very, very important amino acids. So if we have very poor, if we have very, very poor digestion, we have low hydrochloric acid, we have low enzymes, that’s an a play a really, really big role in this whole thing. So getting your enzymes and your stomach acid up really having a clean diet, really breaking down your food, and then really working with a good practitioner to look at the mold toxins or the gut stress the Candida in the gut. Right, and it’s more of an overgrowth, maybe looking at SIBO maybe looking at H. pylori or other gut infections. Looking at the environmental mold, if there is mold, how do we fix it right? What’s the root cause of that mold? Is it a muted humidity issue? Do we just need an air filter? Do we have to do a bio balance protocol in the home to get the mold level down right? So we have to look at the whole picture so we get to the root cause I hope that makes sense. 

Any other questions? Feel free I’ll chime in and try to answer them here for y’all. I think we got most stuff here that’s on point kind of already dialed in. So if you guys want to reach out to Evan, is a console link you can feel free and schedule. Also head over to my site to schedule a consult with myself if you want to dive in deeper we’ll put links down below. If you guys enjoyed this content, share it with friends and family make sure you subscribe hit that like button hit the bell so you get notifications. It’s phenomenal chatting with y’all really appreciate it. Just do me a favor try to apply some of this information so that you can make yourself healthier. It’s really important when you’re healthier. You become a better parent, a better person a better employee, a better boss, and it just it really helps the whole world get better the healthier you get the whole world gets better. Alright guys, it was phenomenal chat and you guys have a great day. Take care. Bye


Audio Podcast:

Natural Solutions for Food Poisoning | Podcast #231

Food poisoning, also referred to as foodborne illness, is illness caused by consuming contaminated food. Infectious organisms — as well as bacteria, viruses, and parasites — or their toxins are the foremost common causes of food poisoning.

In our new episode with Evan Brand, Dr. Justin shared his recent food poisoning experience. He detailed what he did, what medicines he took, and how he overcame with it. He also shared some tips on what medicines to bring when traveling.

Enjoy! Don’t forget to like and subscribe!

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

00:15 Dr. J Food Poisoning Experience

02:36  Food Poisoning Treatment and Remedies

08:23  Gut Issues for Kids

16:26 Enzymes Available

25:14  Candida Diagnosis



Dr. Justin Marchegiani: Hey guys it’s Dr. Justin Marchegiani here. Welcome back to the podcast. Evan, how we are doing today man?

Evan Brand: I’m doing great, good morning to you. We’re ready to talk about food poisoning. You got food poisoning. What was it, a week ago now that we are talking?

Dr. Justin Marchegiani: Yeah, so I was in Boston for a wedding last weekend and I got sick. I was in the north and I did pretty good. I did like a ribeye steak with this broccoli and I was okay, but something didn’t feel right with that kinda mixture. I did go afterwards, and I do this once a year. I did have a cannoli with gluten and dairy in it. So, I did get that. That’s like my one thing cause it’s just like so great. But the previous two years as well, so I’m like, is it really dairy and gluten thing? So there’re just two different light levers here. Alright, you got like food poisoning where it’s like bacteria kinda thing like an e.coli kinda thing. It could be food poisoning AKA an infection like a parasite or bigger bug, or number three, it could be inflammation from the food. Both kinda similar. First thing I did was, I was alright, enzymes, charcoal, ginger, you know, anti-inflammatory southing support that kinda calm things down. And the big thing was I was so noxious. The ginger really helped but it couldn’t keep it down all the way, so that was number one. I’m like, alright. And then I was doing a lot of L glutamine so I’m like, I don’t think this an inflammation thing. It’s lasting a little bit too long. I started to hit a little bit of oil of oregano, didn’t move in a ton, so I was doing my GI clear five oil of oregano, wasn’t moving a ton then I started hitting, when I got back home, my GI clear four and I knocked it right away. So there was some kind of I think a bigger bug in there so I don’t think inflammation that I caught but within a day, within two doses of my GI 4 which has the Berberine the Goldenseal the Burdock the Black Walnut, my nausea went right away. So I’m still on it now I’m gonna take actually one of it as we speak.

Evan Brand: So, were you throwing up or you were just noxious?

Dr. Justin Marchegiani: I didn’t have any diarrhea or any you know throwing up. It was just like just incredible amount of nausea like whoa!

Evan Brand: Like a scale of 1 to 10, 10 is the worst nausea ever, where were you?

Dr. Justin Marchegiani: It was probably like an 8

Evan Brand: Oh, that’s pretty bad…

Dr. Justin Marchegiani: Like I didn’t wanna move like I thought very uncomfortable moving at all.

Evan Brand: and you were flying back home…

Dr. Justin Marchegiani: Oh yeah, I mean what really helped those, those GT Dave’s kombucha, the ginger really really helped. I mean I was doing that…

Evan Brand: You were saying

Dr. Justin Marchegiani: Yeah, I was doing the Kettle & Fire bone broth which is very soothing as well. So I was just doing bone broth, kettle & fire, to the ginger kombucha, and I was hitting probiotics, hitting activated charcoal, and then I was nailing the oil of oregano the last day. The oil of oregano didn’t touch it as much, but the GI Clear 4 really knocked it up. Typically I tell my patients and you travel, go with the GI Clear 4  and 5 when you travel, just to ensure that you don’t have any food poisoning issues or you get an infection. So my generalized stack if you’re traveling is one dose of probiotics, in my line like a probiotic 4, the lactobacillus kinda Hindus lactobacillus  bifidobacteria species, I GI Clear 5 which is a higher dose oil of oregano, and then my GI Clear 4  which is a broader spectrum, bigger parasite kinda killer, and then activated charcoal.

Evan Brand: Yep.

Dr. Justin Marchegiani: Like my big four and then like a little bit of enzymes and HCL too so actually five. That’s my stack for traveling.

Evan Brand: You must have probably picked something up then because that sounds more than just… I mean maybe it was food poisoning. But if it took you to throw in berberine and a lot of these anti-microbial herbs, it sound like to me, I mean I’ll just make up something out of thin air, maybe picked up Clostridia, or some other bacterial pathogen that took you over.

Dr. Justin Marchegiani: Yeah, I mean the oil of oregano didn’t move it as much, but when I got the GI Clear 4, it was like holy smokes. It went away in about 3 hours.

Evan Brand: I was gonna say it was a coincidence that it just got out of your immune system and your immune system mounted the attack or you think it was the herbs that really knocked it out?

Dr. Justin Marchegiani: It was the herbs. I mean I was doing my GI Clear 5 the day before. I did 12 capsules, so I was hitting it hard. Don’t get me wrong, I think it’s still important to do that.

Evan Brand: Yeah.

Dr. Justin Marchegiani: I will just do it centergisticly. I did really good success with the 5 at other types of food poisoning, so it does work very legitimate. I had a parasite in Mexico years back, and that was very helpful but the 4 really did it, so my stack for traveling is GI Clear 4 and 5. But the 4 is like the most important, 5 is kinda secondary, and then the probiotics too are super helpful and I recommend enzyme. You’re eating any questionable foods. Activated charcoal and enzymes and HCL is great. Just to ensure your digesting and breaking everything down.

Evan Brand: I was speaking of enzymes. I was talking to my wife yesterday about how when I went over to your house, you cooked a nice steak for me, and you had your little caddy on your table full of like three different brands of enzymes on your dinner table, I loved that.

Dr. Justin Marchegiani: Yeah. Yep.

Evan Brand: Your wife and your mother-in-law, all of us we had just a whole handful of enzymes we were able to take right there. See I’ve got them in the pantry or in the cabinet in the kitchen, but then you sit down in the table and you forget so you gotta run into the kitchen and grab your enzymes. So I think I’m gonna adopt your roll thereon having enzymes right on the table so you don’t forget ‘em.

Dr. Justin Marchegiani: Yeah. I put them right with the salt and pepper like keep it really simple, really easy, I mean I think the low hanging fruit and functional medicine world is be able to digest your food well. If we spending a lot of money on good quality organic food we wanna make sure we can digest it and break it down especially when you’re eating when you’re stress, because that fight-or-flight   nervous system response really keeps the enzymes and hydrochloric acid levels lower so maybe you’re not making as much, so I think that’s really important.

Evan Brand: Yeah, I’m back on enzymes so, we could talk about this for a minute, you know. A lot of people have the… they’ve got a question of well if I’m taking enzymes, am I making my body lazy? And the answer’s no. it’s not like melatonin where if you take melatonin you can down-regulate your production. With enzymes, you’re really just adding to the fire. You’re not replacing it and that becomes more important as you get older too. But for us, you know we’ve got a baby now and so she’s 4-weeks-old, maybe she’s five weeks, I don’t know. Time’s already flying. But if we’ve got the baby, I’m tryna hold her, mom’s tryna hold her or keep her happy while we’re eating dinner. we’re not optimally digesting, we’re not in parasympathetic tryna keep two kids happy at mealtime. So we’re back on enzymes now just the insurance policy.

Dr. Justin Marchegiani: Yep. And I think it’s great when you’re eating when you’re stress. If you’re doing great and your diet’s really good and you’re feeling stable with everything and you can actually sit down and relax fine. Then I think it’s totally cool that you don’t necessarily need it, as long as digestion overall is good. But if you’re definitely more on the stress side, and you’re eating a meal a little bit faster then I think it’s good to always have them as an insurance policy. I just keep them right there so if I fill the need to have it, I’m right ready to go.

Evan Brand: One thing you didn’t mention, which I think we should mention for you know…

Dr. Justin Marchegiani: Yeah

Evan Brand: Just general… yeah… getting hit with something like that would aloe. You know, there’s a couple different aloe extracts that we used. I’ve got one, do you have your own aloe as well?

Dr. Justin Marchegiani: In my GI restore, I have a 4ml that has aloe TJ and glutamine, so I do like that for gut soothing and gut healing support. And then one thing when I was traveling, I went to whole foods and I bought some aloe juice. So I did get some aloe juice, I would sip in on that. I do find it very soothing and it was very palliative, wasn’t fixing the underlying issue does mean you shouldn’t put it in there. Cause even if you have infection there’s gonna be some level inflammation present so it’s gonna help calm it down.

Evan Brand: True, true. I see so many kids with gut issues. I feel like it’s probably more common than even the adults that I see. I don’t know if it’s just that you know the kids are finding the answers from the pediatrician, so they end up reaching out to us or what but when I’m looking at stool test lately, I’m finding kids’ gut are so much inflamed. I mean I’m seeing 7 or 8 hundred 9 hundred on the calprotectin. It’s like, my Lord.

Dr. Justin Marchegiani: And that’s a very high level I mean that basically in like irritable vowel disease kinda category. You know that you’d see the crones and also the fled, that’s really high. And I think a lot of it is you see have more crap food out there for kids today. I mean my God, it’s very rare to see kids eating whole foods. It’s very rare to see kids even just drink water like my son, he drinks sparkling mineral water, he drinks water and he drinks unsweetened crane juice like with kale, broccoli, spinach, like no added fruit, no added sugar at all outside on what on those green vegetables. And then he has meet sole for breakfast, still have half of an avocado today, a piece and half of bacon, and then maybe a couple of blackberries and some coconut unsweetened vanilla yogurt. Like that’s it, that’s his breakfast and for lunch, it’s tough with kiddos so I try to always recommend with parents, whole cuts tend to work really well on kids just choose a higher quality one. Like at the Applegate or the Wellshire Farm works at least at step two, so you at least getting a pretty good quality, or if we do the hotdogs, we get the Wholefood step 4 so they’re at least grass-fed and organic in pastrofed hotdog so at least the meat quality is high so those are good.

Evan Brand: Another uncured as well so…

Dr. Justin Marchegiani: Yep

Evan Brand: You’re not having bunch of night trades or other sodium into rebates added, you don’t want those.

Dr. Justin Marchegiani: Yeah. That’s overblown kinda thing, especially it’s coming from celery powder. But either way,the more important thing is the food quality is there. And if we can’t get the vegetables in, we at least do the green juice. He’ll pound 8 to 10 ounces of high-quality green vegetable juice a day. That’s helpful.

Evan Brand: I gotta tell you about something. I just found today and we ate it this morning, it was absolutely so delicious so my wife wanted to do waffles for a long time so we were looking at all these different grain-free waffle recipes, but we went to Wholefoods and there’s this brand called Swapples. Do you know Swapples?

Dr. Justin Marchegiani: No, I don’t know Swapple.

Evan Brand: Oh my God, alright so I’ll send you the link here. But they’re grain-free like this is an autoimmune approved. I got the cinnamon one, I’ll send you the link here. This thing was so good, I thought this can’t be real how good this is. So it’s yucca, let’s see let me tell you the ingredients here. Yucca, coconut oil, organic coconut palm sugar, 2 grams of sugar, I think per waffle, cinnamon, sea salt, vanilla extract.

Dr. Justin Marchegiani: Swapples, okay I’ll put some links in the description below. That’s awesome. Are they premade already?

Evan Brand: Yeah, it’s premade. You just throw it in the oven for like 10 minutes at 375 and its ready.

Dr. Justin Marchegiani: That is awesome dude. That’s really cool, Swapples. Okay cool.

Evan Brand: I think you told me when you were in Austin that you say you goy yucca, yucca pancakes that you got?

Dr. Justin Marchegiani: Well I picnicked, yeah anyone that knows picnic is awesome for their autoimmune gluten-free, grain-free type of foods they have great yucca-based waffle and pancakes. So I would do like blueberry pancake.

Evan Brand: That’s delicious. So they have other ones too that people can use like as a bread replacement. Still gonna be you know, carbohydrates. If you trying to stay in ketosis or something, this is not gonna work for you. But they got like a tomato basil one which is the yucca, however you say it, coconut oil, tomato, sea salt, spice, and garlic. So if you’re like one of those people who just can’t leave without bread, and it’s like pulling teeth for you, for us to get you to an autoimmune template, you may be able to do something like this instead and get you off of the grains, I mean.

Dr. Justin Marchegiani: Yeah, I like that.

Evan Brand: I love the stuff like this exist.

Dr. Justin Marchegiani: That’s awesome. Yeah, have a recipe in my website basically it pretty simple it’s a half cup of coconut milk, 2 and half cup of coconut flour, to four eggs. That’s it. And it’s blended up and then we use a waffle maker and we just put it in there, it’s done. So that’s another good option too if you wanna make it, coconut flour, coconut milk, and eggs. But this is not a great option, it’s always nice to have them pre-made so if you’re in a rush you just can heat them up fast and be done with it.

Evan Brand: Yep, absolutely.

Dr. Justin Marchegiani: That’s great.

Evan Brand: I wanna share that cause like people are always like looking for things cause they wanna get off their diet, you know they’re like “oh I feel deprived, or I miss this food. I miss that food” I mean I’m still trying to get my grandfather off chocolate milk, you know. So, it’s like we got a long way to go. People would think our families listen to us on everything but at least my family doesn’t.

Dr. Justin Marchegiani: Yeah, it’s tough. For sure the key this is to have substitution mindset like what’s the substitute, what’s the switch, what can we incorporate in there that will provide similar mouthfeel, will you feel good about it, you enjoy, the taste’s good, but you’re not getting the crap. So, I love options like these. Especially the carbohydrates and the sugar in a pretty good spot. So, I like it. That makes a lot of sense man.

Evan Brand: What about the serials and all that? Have you found any alternatives? Cause so many people “why do I do I can’t have serial anymore?”. Like what do you push people towards in the morning?

Dr. Justin Marchegiani: There’re some decent lite paleo granola that’s out there that’s more nut and seed based. So that pretty good. And then you can use like a coconut milk kinda thing for it. If you’re on autoimmune templet, that wouldn’t be as good because its nut and seed based.

Evan Brand: Right.

Dr. Justin Marchegiani: That’s a good option as well in the morning. Option number 2 is just a really simple collagen-based smoothie, you know, some good collagen powder, unsweetened coconut milk, and then some frozen berries. Or just you know, a butter collagen-based coffee, butter collagen-based tea. Or kinda like my go-to is pretty simple, pretty easy. Yesterday we went out to eat in a restaurant near us that we, I was able to get like an egg florentine, so it was like an eggs benedict with over bacon and vegetable, and tomatoes.  So it was like a really nice kinda lower carb, good fats, good protein, tasted really good, felt good. I don’t get a chance to do much eggs benedict so when I go out, I’m all over that.

Evan Brand: Nice, we had a question here from James. Happy Monday to you James. He says that, when we talk about gut health, what organs are we referring to besides the stomach?

Dr. Justin Marchegiani: So when we look at the intestinal tract, right, we have a mouth, that connects to our esophagus, connect to our stomach, our stomach then connects to our small intestine, three parts of the small intestine duodenum, jejunum, and ileum, then down here at the… at this side, bottom right-hand side. The ileum and the cecum meet up. This is where the colon starts, the colons up here, ascending, transverse, descending, sigmoid and then anus rectum. So, that’s kinda your generalized intestinal track. Everything from mouth to esophagus to stomach to small intestine to large intestine to rectum, anus and out in the toilet, that’s it.

Evan Brand: Yeah, and then organs. So other organs we’re referring to, gallbladder is a part of digestive process, pancreas.

Dr. Justin Marchegiani: Gallbladder and liver, its gonna be hanging out right here that dumps into the small intestine to be the duano hepatic ampulla. That’s a big one, splints more of a red blood cell kinda graveyard. Not much with the splints

Evan Brand: Pancreas.

Dr. Justin Marchegiani: Pancreas will help more excrete whites with the enzymes, it will help with the blood sugar component from the insulin and glucagon.

Evan Brand: Depending on how crazy your mealtime is. If you’re one of those people, you know how many people I see driving on the highway eating, stop doing that people. Eating sandwiches while they’re on the highway like trying to merge on. Lady’s got like a wrapper with a burger on her hand.

Dr. Justin Marchegiani: The worst time to be eating, I mean definitely fight-or-flight nervous system response. I hope they’re at least doing some hydrochloric acid and enzymes but they’re eating a sandwich. Probably not there yet.

Evan Brand: no, they are not there yet.

Dr. Justin Marchegiani: Exactly

Evan Brand: Here’s a question from Carol, she said, love the idea of keeping the enzymes on the table. What company are you purchasing your enzymes from? We have costume manufacturing, so we work with several professional health care companies for practitioners, and they make special blend and products for us. So, you could check out Justine’s site, Just In health, Ge’s got several different enzymes on there, I do on my site as well.

Dr. Justin Marchegiani: Correct, yeah mine’s enzyme synergy, HCL supreme, and then digest energy is kinda my lower dose enzyme hcl, blend I like those. Evan has… Evan, what’s the name of yours?

Evan Brand: Mine’s pure digest. That’s my go to. That’s the one that got DPP 4 in there for an accidental gluten exposure. 200mg butane per capsule. Here’s a question from Matt, ill be taking a trip to Greece sometime next year, definitely will take charcoal and enzymes, I’m mostly worried with water, all I drink is reverse osmosis. Do I just resort to bottled water?

Yeah, I mean I don’t see an issue with bottled water. Or if you want something that… if your just like super anti-plastic, you could do the Berkey sport, the little blue bottle, I think I may be made of silicone but it’s got the berky filter in there and you just out in your tap water and you can suck it up through the straw and as you’re sucking to the straw, it pulls the water through the filter, now it’s incredible and its relatively cheap too.

Dr. Justin Marchegiani: Yeah those were good. I don’t have problem with drinking out of a plastic bottle it its you know, special occasion kind of thing. Like in general, like I was up in a bout this weekend and I rough like a whole bunch of chiccos with me. So, I was able to do that, but sometimes it’s just not convenient because I don’t want the glass breaking, you know. O I don’t want the glass clanging around my ca from there. So sometimes I use that can, I use another type of water sparkling brand or you know. I’m typically doing fiji for a higher silica, or I’ll do the evy on for the high mineral content. I’ll do that. The key thing is, just make sure you keep it out of the sun. if it’s plastic, you know. If I’m outside drinking it, I have a backpack and it goes right in the backpack afterward. I don’t wanna have it the sun’s rays. My biggest concern with water is they just put it on the pallet, leave it outside, let it sit in the sun. so typically, you know, you want it pulled inside right away because the UV Rays from the sun will cause the plastic to deleach some of those estrogen compounds in the water.

Evan Brand: Yeah, I trust like Wholefoods the way they handle their stuff cuz if they get a truck full of fiji water, they’re gonna unload the truck directly from the truck un the darkness and in to the store and then the case of the water may even be inside of a cardboard box there where you are not getting the sunlight to hit it.

Dr. Justin Marchegiani: Yeah. Wholefoods, in those stores they have… you can just see right. They have a smooth tracking containment inside the store. You’re pretty darn safe cause it’s going from inside to outside or inside the store pretty smoothly. So that’s at least a good option for it. So, I like that.

Evan Brand: Yep. We had a question here from Judith, she says she has an H. Pylori. She can’t get better and she’s got pain constantly. She’s using Matula tea, everything makes her tremor. I don’t know if she’s talking tremor like T-R-E-M-O-R, but she spelled it tremor like a tremor for your hair, and anxiousness. So, yeah I mean if you got H. pillory, obviously there’s some random supplement that Justine and I both have that could help that. But really, you wanna be working with somebody with this cause if you’re in pain constantly and you’re anxious, there could be some other things you need to do. We don’t necessarily want to give you H. pylori herb or you may need adrenal support and other things.

Dr. Justin Marchegiani: There could be other infections going on there. A lot of people who are going after gut infections, they don’t have the ability to regulate blood sugar and energy, and they tend to feel more anxious like this. This is a common symptom that I see when people just go after the gut and don’t fix the other things first.

Evan Brand: Yeah.

Dr. Justin Marchegiani: So, this is a common side effect. This is why we really wanna have a comprehensive program lined up and not just spot treat people with a gut bug. Sometimes you can do that when people are in really really really really good health and their infections are more acute. You can totally do that. But in more something chronic, in a more other fatigue,harder issues are in play, you really have to line things up and a really systematic approach to get the best results.

Evan Brand: Yep. Yeah. Well said. So, Oliver asks; Do you guys tolerate raw milk kefir? I don’t do any. I probably tolerate it; I just don’t do it.

Dr. Justin Marchegiani: I don’t do well. I had a patient get me a gown of like really awesome super high-quality grass-fed pastored milk and I’d still have a lot of diarrhea from it. So, I’m just like, it’s not worth it for me. The only dairy that I can do well is yea and butter and then if I do kefir, its gonna be coconut based, I’ll do coconut based kefir.

Evan Brand: Yeah, it’s just not worth it for me to try so, I just don’t.

Dr. Justin Marchegiani: Exactly. Suzanne writes; What can I do to fight hunger cravings. I do not eat after 5 pm but I wake up crazy hungry. I drink a lot of lemon water with some Himalayan salt.

So, yeah. You probably need to be eating a little bit later. If you’re going to bed around 10-11, that’s you know, 5-6 hours before going to bed without food. So, there could be some blood sugar instability happening. So, if you’re walking up at night, you may wanna have a nice, little, simple snack, protein and fat by your nightstand and try eating within 2 hours before bed. Again, if we’re having blood sugar issues and those sugar issues are waking you up, that’s the next logical step.

Evan Brand: Yeah, may need some adrenal support, you may need some chromium, you could throw some cinnamon on a baked sweet potato with butter. Have that for dinner that may stabilize the blood sugar a little bit too. I really really love using chromium and other minerals to help so, there’re herbs that you can use too. There are some like glucose, modulating glucose control herbs that we use, but once again, that’s something that you don’t wanna guess and check on. You gotta get to the root cause.

Dr. Justin Marchegiani: And then Carol writes in; Are your products that you mentioned safe for 2 years old and up?

It depends, most 2-year-old can’t swallow pills that are in our product so we have special tincture that are liquid based and they tend to be easier to dose. So, we can dose them. We like the tinctures for the younger people.

Evan Brand: there are couple chewable products we used for kids too that kinda depending on what it is.

Dr. Justin Marchegiani: You’re talking chewable for actually like clearing herbs?

Evan Brand: Uhh no. I’m talking for digestion.

Dr. Justin Marchegiani: For enzymes stuff.

Evan Brand: Yeah, chewable enzymes.

Dr. Justin Marchegiani: Yep.

Evan Brand: Chewable aloes, things like that.

Dr. Justin Marchegiani: Yep. There’s some DGL and aloe up there I’ve seen and then there are some enzymes that chewable that are good.

Evan Brand: I know. For killing, no. I don’t know of anything that can kill that’s chewable.

Dr. Justin Marchegiani: Exactly. There are pump based that I like and then dropper ones that are dropped based. Then you can kinda dial that dosage up. So those are the ones we typically like and we can dose it up better. Just more individualized.

Evan Brand: Judith had a question. She said; can I call on the phone, please?

You know that what that makes me think off? That makes me think we should have like a call in podcast where people can call in and talk and tell their questions on you know, like on the air so to speak, like a radio. That would be fun.

Dr. Justin Marchegiani: Yeah.

Evan Brand: I don’t know how we do it. Im,sure there’s a way.

Dr. Justin Marchegiani: Yeah. I’m open to that. For sure I think I need some kind of a call board and plug it into my computer. Something we can look at. Anyone has information on it, let us know. We’ll put it in a queue.

Evan Brand: That would be fun.

Dr. Justin Marchegiani: Couple more questions, George writes in. hey,George hope you’re doing well. I typically do ashwagandha to dry herbs versus the tincture. Ashwagandha and tincture taste absolutely horrid especially if you take wrong ashwagandha. One of the worst tasting herbs next to Tribulus.

Evan Brand: I do ashwagandha and tincture actually with the sooth formula, the adrenal sooth formula I do and I mean…

Dr. Justin Marchegiani: Blend?

Evan Brand: Yeah it is a blend. I mean it does have; well it has motherwort in it which is equally.

Dr. Justin Marchegiani: There’s liquorish too?

Evan Brand: Uhh. No there’re no liquorish. Its ashwagandha, rishi, motherwort, ziziphus, albizzia. It’ pretty horrid. I have a lot of clients who like “I just can’t do it”.

Dr. Justin Marchegiani: Okay. Yeah yeah yeah yeah yeah. But there’s a blend. But if you do ashwagandha 2 to 1, meaning 2 times the amount of herbs to the alcohol’s in there, most people do like awanda 2 or awanda 5. So, its literally 5 to 10 times less potent. It’s not even close. But when you really do 2 to 1, it’s like holy god! It’s crazy.

Evan Brand: Oh man. Judith, how can you contact us. So, Justine, you can reach Justine at his site, there’s a scheduling button if you need to schedule a call or there’s also contact information if you just wanna email.

Let’s see what else here. Me, my site,, same thing.

Dr. Justin Marchegiani: Yep.

Evan Brand: Do you wanna answer this one here from Christian?

Dr. Justin Marchegiani: Yup. 9 months ago, I was diagnosed with candida, came up 40 on my oats test, feeling a lot better and got rid of it, lost too much weight, how can I gain back the weight and not look sick? So, first thing first. Not to be a wise guy, but you have to make sure you’re eating enough. That’s number 1. You have to make sure you’re getting enough calories. Sometime when people do a lot of killing, that killing can actually decrease the appetite. So you have to actually run your food chronometer., make sure you’re getting enough calories, number 1. Number 2, if you’re more of an ectomorph or its hard for you to gain weight, you also have to look at your macronutrient ratio. Ratio a protein fat carbs and increases the percentage of your carbs. So, if you’re 30 of 40 percent go to 50 of 60 percent. And still, ry to make sure you’re doing grain free based carbs. Don’t get extra grains in there just to get more carbs. Do more squash, sweet potato, plantains, you know those kinds of things instead.

Evan Brand: You know what I’m gonna say based on his comment, right. I’m gonna say there’s probably more than just candida, you know.

Dr. Justin Marchegiani: Yeah, and if you’re feeling better and you’ve gotten retest, that’s great. But you would also wanna get a high-quality gut test on because the oat will not look out the parasites. It won’t get the parasite. It will look out bacteria and fungal metabolize and that’s it.

Evan Brand: it’s extremely rare. I mean whoever they say 9 months ago they were diagnosed with candida. Whoever diagnosed you with that, I mean I can legally diagnose anyway, but I would be very very suspicious that you had just candida. It’s very rare to see. I guarantee there’s probably maybe some parasite, bacterial overgrowth, h. pillory. Something else going one cause I feel like candida’s usually kinda late to the party whereas the bacteria and the low HCL from the h. pillory and the parasite, those kinda disrupt the gut and then I feel like candida moves in. I guess it could happen. Chicken or egg, who cares. But I feel like candida is a secondary issue to a primary parasite.

Dr. Justin Marchegiani: Exactly and typically the timing of how we treat. We typically do the h. pillory first, parasite, bacteria, 2nd or 3rd and then candida last. That’s kinda the general way in which we treat, Robert. Hope that helps.

Evan Brand: Yeah, Robert’s question for those listening, he had a question on what should you go after first. Candida or sibo? I mean honestly, a lot of the herbs used tho have multiple properties that we may use blends of herbs that are anti-microbial and anti-fungal so you kinda killing 2 birds in 1 stone. But I guess it depends on the serenity of one issue we may use more inti fungal as a posting, anti-microbial if its parasites who may have parasitic herbs that could kill fungus. So, its really just case by case basis.

Dr. Justin Marchegiani: Totally. And I thank Guererro about this zoom meeting thing. I’ll keep that in mind, I think it’s good. Matt writes in; Would there ever be any benefit to not save carbs for the evening? So, meaning to do your carbs in the morning. So, that’s like kinda common sense where lot of people load up carbs in the morning. Again some of the data suggest in the carb backloading community that better at night. There’s also some data that some people tend to sleep better with a little it of carbs in their system at night. Also tends to help with fat burning and such. So, I typically always, let’s just say lean on the carb backloading mindset but always tested out. I mean there’s data out there but then you gotta use your clinical experience. So test it out to see how you do and see how you feel.

Evan Brand: Yeah, I got a question from Jac. Should one take probiotics daily?

I mean that’s like such an open-ended question. I mean we could spend an hour on that subject. We probably have spent hours on it. I’m kinda on and on face right now with probiotics. I’m doing some special probiotics blends to help lower regulate histamine. And then I’m also doing some Saccharomyces boulardii. So, I’m doing those daily for probably months, but now with my daughter, cycle her on and off probiotics, throwing some Saccharomyces. It kinda just depends on what you’re doing.

Dr. Justin Marchegiani: Correct, correct. Now in general about people taking herbs between meals, couple things to say about that is, I use to say like do your herbs hundred percent before food, which I think is great. You typically take at least five minutes before food. the problem is you get a lot of patients that are like they forget, and they just won’t do it. Then they’ll forget half a time so then half a time they’ll never taking the herbs. So, my perspective is ideally five, five minutes or more is fine especially you’re not getting nauseous, but if you forget, still have it. Like still have it, always do it. Eating your food and forgetting is not an excuse to not take it. I always try to draw that line with patients and if the patients are more sensitive, we’ll typically do it with food anyway just so it mixes in and it’s a little bit less potent as well.

Evan Brand: Yeah, the question Justin was answering was should you take herbs between meals or with meals. I would say amino acids. That wasn’t the question but just to overeducate people. Amino acids, we’ll like to have those on empty stomach cause they can peak. But hers, I like herbs with meal and a lot of gut killing protocols we do the herbs are suggested with meals.

Dr. Justin Marchegiani: Yes, exactly.

Evan Brand: I think that was different question unless you saw more then we can kinda circle back to the food poisoning thing and then talk about testing real quick and wrap it up.

Dr. Justin Marchegiani: I appreciate Judith’s comment as well. I got a question here from Facebook from Dawn. Dawn hope you’re doing well. What type of protein powder do you recommend for smoothies? So, Dawn, for like autoimmune kinda template, we typically lean more on just plain collagen or just plain P protein.  So those are the big ones that will do if we’re just kinda on more autoimmune side, and then typically gotta low sugar berries, ripe berries, blueberries, raspberries,  they can be frozen, and then some unsweetened coconut milk tends to be a pretty good shake option. And then in my line,I do the true collagen to the true P and then I have one called the true keto collagen, which is a really good collagen-based smoothie that sweetened with vanilla and cinnamon and that is still autoimmune approved. It got some MCT oil, I added some taurine in there and a couple more amino acids and coconut colostrum. So, that one’s a really good one and it mixes awesome with unsweetened coconut milk.

Evan Brand: Nice, I mean I’ve not had… many people have issues with hemp. Hemp protein. A good organic hemp protein could be okay. Some people don’t like, feel like they digested as well as the P, but I feel okay with hemp.

Dr. Justin Marchegiani: Yeah, I mean if someone’s on autoimmune, I would say no. but if they’ve been able to kinda reintroduce nuts and seeds, and they’re doing good then I think it’s fine. I don’t have a problem with that.

Evan Brand: Okay. So, circling back if you’re ready. Circle back to the conversation, we started about the food poisoning and going put to restaurants and traveling and all that. We talked about kind of preparation kit of having your binders like your charcoal, your soothing gut nutrients, like maybe your aloe, and your glutamine. You mentioned using some of your GI Clear 4 and 5 products with like berberine and anti-microbial herbs like oregano oil and then I would just say doing a once a year testing on your gut system, My daughter just turned 3 over the weekend, and we’ve already done 5 stool tests on her. She’s not even 3 years old yet. But that’s cause she has a lot of issues on het stool. So, she had h. pylori, then we got rid of it. Then had 2 parasites, then we got rid of those. Then she had a bunch of bacterial overgrowth, then we addressed that. Then she had candida, now we’re working on that. So, man it’s been a, it’s been a ringer what she’d gone thru. So, for her, we’re doing more often than once a year for testing, but I would look getting an organic acid urine test we’re on. And we’re often running that through a mycotox screen now where we can look at mold toxins for people, because diarrhea and abdominal pain can be caused by mold, by mycotoxins. So, we’re running that now cause sometimes we find people don’t have gut infections, but they have mold that’s why their body is creating diarrhea cause they’re trying to flush out toxins. So, doing the urine once a year would be a good idea and then doing the stool test, we like to use GI Map stool test. We often use that one. And that’s a DNA-based one where we can look at all the different infections people have. We can look at your inflammation to determine well, is it the infection, is it the inflammation, is it both. How’s your pancreatic enzymes function look. Are you eating and reacting to gluten? How’s that look. How’s your fat digestion look. We can get all those pieces of data. Just really at the end of the day a lot of people have these great questions here. But a lot of questions are… they’re too general, and really you need a clinical data. You need to see the answer… the question, do I need probiotics daily. Well, I don’t know. Why don’t we look at your bacteria flora, and if you’re low across the board, the answer would be yes.

Dr. Justin Marchegiani: One hundred percent. So in general for everyone who’s traveling and has a food poisoning issue or wants to be careful, it could be a food poisoning where food poisoning could mean like there’s just mold in the food, there could be some E. coli in there. Then you upgrade to like infections like h pylori and actual parasites, there could be a little bit longer lasting that aren’t gonna go away at night and then you obviously have food allergens and the inflammation from food allergens. Whether its glute, whether it’s the junkie vegetable oils, MSG, those kinda thing. So, typically the charcoal, the enzymes, the HCL are great for binding up the bad foods and maybe the infections. If you have the issues and they’re acute, you wanna hit the GI Clear 4, GI Clear 5, oil of oregano, Goldenseal, higher dose or berberine. Those things are gonna be great. Higher dose probiotics lactobacillus bifidobacter, enzyme, HCL, activated charcoal with the food at that point. We do not worry about taking charcoal before meals when we are eating questionable foods or when we are sick. We try to bind things up. And prevent excessive diarrhea and such.

Evan Brand: Yeah there was a question earlier about like a shilajit and fulvic acids. I used a product that has charcoal and fulvic acid in it and shilajit as well. And its from Beyond Balance that’s a practitioner company. You need a practitioner to order that. But it’s a product that we use called tox-e bind. And it’s a binder. Very very helpful. So I’m using that personally and have a really good experience with it.

Dr. Justin Marchegiani: Exactly, I love that. Very good. Well,today was a great chat, man. Excellent. If you guys enjoying the podcast, make sure you head over to Evan’s got some great information there. Really good stuff. as well to reach out to me. And of course, you can schedule consult with Evan and myself if you want to dive in deeper. And if you’re enjoying these guys, smash the like button, hit the share, hit that bell so you get notifications. We appreciate connecting with you all and we will be back next week. You guys have a phenomenal day, talk soon.

Evan Brand: Take care.

Dr. Justin Marchegiani: Take care, Evan. Bye.

Evan Brand: Bye.


Audio Podcast:

Candida Summit with Evan Brand – Podcast #181

Welcome to the Candida Summit! In this video, Dr. Justin Marchegiani interviews Evan Brand, an internationally-based functional expert who specializes in digestive issues and chronic infections, obesity and fatigue. Listen as Evan Brand shares his personal experiences with Candida and his protocols to overcome it.

Don’t miss the chance of listening to this knowledge-filled interview! Stay tuned!

Dr. Justin Marchegiani

In this episode, we cover:

01:20   Candida, Mood & Cognitive Issues, and Other Infections

06:26   Multiple Mechanisms of Candida

12:00   Diet Does Not Affect Skin Myth

23:21   Lab tests for Candida Overgrowth

63:00   Treatment Issues for the Immune System


Dr. Justin Marchegiani: Hey, guys! It’s Dr. Justin Marchegiani here. Welcome to the Candida Summit. I have the honor of hosting this interview with my good friend and colleague, Evan Brand. Everyone knows Evan here. Six million downloads, internationally-based functional medicine expert. You can reach him via phone and Skype. He specializes in digestive issues, Chronic infections, Obesity, Fatigue. He’s had his own issues with IBS and Mood Issues, and he’s been able to overcome it with a functional medicine approach that gets to the root cause. Evan also has a couple of books. The “Stress Solution,” “REM Rehab.” There’s a lot of stuff on Nootropics as well. And again, you can always get a hold of Evan. Schedule a complimentary consult at See if you’re a good fit for the next step. But, Evan, how are we doing, man? Really happy to be connected.

Evan Brand: Hey, man. Thank you so much. We have had hundreds of hours of fun together over the last few years so…

Dr. Justin Marchegiani: Yeah.

Evan Brand: …of course, there’s no one else that I would want to be interviewed by than yours truly. So, uh— thank you. Thank you for the opportunity.

Dr. Justin Marchegiani: So excited to be here. So, let’s talk about Candida. So, Candida’s one of these things where it’s like, “Oh.” You know— Back in the 70’s and 80’s, it’s like, “Oh, the yeast connection.” “Oh. It’s Candida causing all my problems.” And it’s interesting ‘cause we talked about this a lot, on air, where Candida, a lot of times, can be connected with other types of infection. So, I’m just curious. How often are you seeing, in your patients, just a— a pure Candida issue that’s driving the problems? Or is Candida there with other types of infections that you’re saying?

Evan Brand: Yeah. Great question. I’d say, maybe five percent of the time, it’s Candida by itself..

Dr. Justin Marchegiani: Yeah.

Evan Brand: And if I hit that five percent of the time, I’m thinking, “Okay. Something must have got missed because, the other 95 percent of the time, it’s Giardia issue, it’s a Crypto issue, like what I had going on when I had Candida problems, personally. And of course, Adrenal issues are always happening. Thyroid issues can be happening. So, if somebody just has Candida, it’s like, “Okay. Something’s weird or you just got lucky, because it usually never happens that way.”

Dr. Justin Marchegiani: Yeah. I see the same thing as well, clinically. And some people, you know— Candida can be a big issue. There’s something called the Auto-brewery S— uhm— Auto-Brewery Syndrome. Are you aware of that?

Evan Brand: Yes. Basically, where you’re getting drunk, right, on your own…

Dr. Justin Marchegiani: Yeah.

Evan Brand: …Candida?

Dr. Justin Marchegiani: Yeah. Part of the metabolites of Candida is Acetaldehyde, and Acetaldehyde basically goes to your liver and is like— is a stressor kind of like Alcohol is.

Evan Brand: Yeah. Well, the good thing is, we can fix the yeast and then we can use other things to soak it up too. I’ve been using some of those Fulvic acid supplements…

Dr. Justin Marchegiani: Uhmhm—

Evan Brand: …that we spoke about to try to suck it up. And basically, any type of a binder, like clays or your Fulvic acids— these binders, you can kind of soak up that Aldehyde, which is cool, because if you are getting drunk on your own Candida, that’s not the root cause of deficiency of— of clay or charcoal. But, if that can help you ten percent better while we work on fixing the other issues, that’s— that’s a win.

Dr. Justin Marchegiani: And I see a lot of Candida people. People that have a Candida overgrowth, they also end up developing like neurological or mood issues. What’s your experience with patients with Candida and Mood, or brain or cognitive issues?

Evan Brand: Yeah, it’s huge. I mean, that was me, right? I always like to talk about me first just because I like to tell people, “Hey, look. I’ve already been there, done that. I’ve struggled. I’ve suffered.” I feel like— and I know you would agree too that as a practitioner, it’s much, much better if you have dealt with the exact same problem that you’re working with your clients on, as opposed to you got some of these medical doctors where they’re prescribing drugs that they would never take themselves. They’re prescribing Statins and Beta-Blockers, and etc., etc., etc. And people may say, well, they might not need those drugs. If there are Cardiologists, they might not need a heart rhythm drug but— you know— in our space, you and I take everything that we’ve recommended for people. We take our own herbs. We formulate our own supplements. We take our own fish oils. We take our own anti-parasitics if we show up with parasites. So, back to the original question about the mood issues— I mean, I dealt with Depression for probably ten years, if not more. Like, the more— the more that I do interviews, I realize that even as a kid and as a teenager, I was depressed. And I still had a great childhood, but I just wonder if it goes back to something when I was very, very young. Like, you talked with Dr. Dietrich Klinghardt and he says that— you know— traumatic experiences, even before age two (2) can cause issues later in life. It’s like, “Well, I have no idea what happened before age two (2), so I just wonder if— if something like that happened to where a roll of the dice led me to be more depressed. And then, of course, my parents— you know— They struggle a lot with Depression on both sides so of course the genetic epigenetic component is— is part of it. And then the infections. I mean, you were the first guy who looked at me and you said, “Dude, I guarantee you’ve got gut bugs,” because you saw old pictures of me and I had a lot more muscle than I did. When you saw me like, “Dude, what happened to your muscle strength?” I was like, “I don’t know.” And you’re like, “Okay. You need to run a Stool Test on your self.” And, that’s when I had ran some comprehensive stuff and found out I had gut bugs. And that was the answer I was looking for because my mental health was affected it wasn’t just the gut. It wasn’t just the weight loss. It was the Insomnia, which leads to…

Dr. Justin Marchegiani: Totally.

Evan Brand: …Brain Fog because you’re tired. And then, the Brain Fog leads to Anxiety ‘cause you can’t focus. So, then, you’re anxious that you can’t get your work done, and your boss is like, “Hey. This project is due. Where is it at?” And you can’t do it ‘cause your brain’s not working. So— i mean, Candida can be a massive, massive health issue and is not something that I think people should just write a blog about. “Ten Ways to Fix Candida,” It doesn’t work that way. You can’t just throw a bunch of stuff at this with a Shotgun Approach and get good— good results. I’m literally, probably, gonna make  T-shirts one day that have the term supplement graveyard on there ‘cause every person I talked with, they tell me they loved that term that I used because…

Dr. Justin Marchegiani: Oh, yeah.

Evan Brand: I have a supplement graveyard and they— they usually do two of— of supplements they tried but that they didn’t follow through with.

Dr. Justin Marchegiani: A hundred percent. And, what’s the mechanism of Candida and Yeast and Fungus? And just, for the listeners, right? We have like the big umbrella is fungus, right? And then, we have Yeast i like a various— you know— type of fungus underneath that umbrella, and Candida is in one of those kind of yeast families. What’s the mechanism of Candida or these yeasts uhm— causing neurological and brain and cognitive issues?

Evan Brand: I would say, there’s multiple mechanisms. One, which is with something that Dain Kailash and I chatted about is Mitochondria being affected.

Dr. Justin Marchegiani: Yeah.

Evan Brand: So, that can affect the energy levels because you’ve got the toxins that are being created by the Yeast. You talked about like the Brewery Syndrome.

Dr. Justin Marchegiani: Yep.

Evan Brand: And so, that’s affecting the Mitochondria. That’s affecting the liver too. So, if we’ve got a lot of things in the gut, like parasites and bacteria, plus the Candida, the liver’s overburdened. So now, the liver’s having a backup, so to speak, and that can cause fatigue. And then of course that fatigue can lead to depression, possibly anxiety then sleep issues. For me, I had terrible sleep issues when my liver was overburning ‘cause I have so many bugs. I would say another mechanism, too, would just be the malabsorption that Candida’s causing because— you know— you and I ran a lot of Organic Acids Testing. And when we look at our clients’ lab results, we see the amino acids are very low, meaning they’re not digesting their proteins well. We see their neurotransmitter’s low so we’ll look at markers like HVA, which called Homovanillate— you and I talked about that all the time— which is a Dopamine marker. And, we see neurotransmitters drop too. So now, the person has lack of energy. They have lack of drive. They can’t focus. They have lack of concentration. They’re easily bored. And this is because their neurotransmitters are not being produced. Then we see Serotonin being low. That’s another mechanism of the Yeast because most of it’s produced in the gut. And if the gut is in a state of dysbiosis, meaning you’ve got bad guys that have moved into the neighborhood, all the good guys are being crowded out, you can’t manufacture neurotransmitters like you’re supposed to. So, when Serotonin is low, then you’ve got the irritability, you’ve got the panic, you’ve got the phobias, you’ve got the sugar cravings, you’ve got mood swings, winter depression, PMS. And so, just to summarize, I would say, the mechanism is affecting the liver ‘cause of the toxins. I would say, it’s affecting Mitochondria ‘cause of the toxins. It’s creating a permeable gut barrier so it’s creating leaky gut, which is causing malabsorption. So, even if you’re eating organic Paleo template, which is what we kind of promote, and— let’s say, your brain chemistry. It is the other mechanism that’s affected.

Dr. Justin Marchegiani: Yeah, 100%. And there’s one toxin that’s actually produced by the Candida. So, you have Candida, which then produces the Acetaldehyde. The Acetaldehyde produces a toxin, a neurotoxin called Salsolinol, and that Salsolinol can make its way up to the midbrain, and actually start killing off some of these Dopamine-producing cells in the Substantia nigra. [crosstalk] And that’s because—

Evan Brand: Spell that.

Dr. Justin Marchegiani: So, yeah. The compound is Sal—  S-A-L-S-O-L-I-N-O-L, Salsolinol. And that’s synthesized from Acetaldehyde and can affect the Dopamine-producing cells in the brain, in the midbrain, in the Substantia nigra. So, that’s another mechanism ‘cause Dopamine’s really important for focus. It’s really important for mood. It’s that reward center neurotransmitter that gets secreted— you know— during happy moments and it’s important for focus, too, right? People that are trying to go on these antidepressants are using that. So, that’s another mechanism too.

Evan Brand: You know what’s crazy too uh— that Salsolinol— I’m just reading a little article here. It says it’s a metabolic product of fermentation…

Dr. Justin Marchegiani: Uhmhm—

Evan Brand: …found in small amounts in several foods, most notably chocolate, and it’s believed to be the addictive component of chocolate and alcohol. That’s pretty interesting. I didn’t know about the link between chocolate, alcohol and this compound.  

Dr. Justin Marchegiani: Exactly. And then, my thing with the Candida, as well, maybe you’ve experienced it, but so many conventional medical doctors, they really poopoo it. They really put it down like it’s some— like, thing that’s just not real, even when we have data like Candida via a GI Map Test or Candida antibodies, or D-Arabinitol via an Organic Test. What’s your experience with that?

Evan Brand: Yeah. Well, I had two medical docs that are both Gastroenterologist on the Summit. So, Ken Brown joined us and then uh— Parthenon D joined us. And they both admitted that the tide has turned, or at least is turning in the conventional Gastroenterology world, and that now when they go to, like, conventional medical doctor conferences, Candida is being brought up, as well as leaky gut. When they’re saying like five years ago even, leaky gut was laughed at. And, of course, Candida was laughed at too. So, those are at least two guys who give me hope that, “Hey. Maybe this is gonna turn the tide.” But, I mean, every single week, countless times, you and I, both, hear the same story, which is that the conventional doctors laughed at them, and if they talk about using herbs to treat something like Candida or parasites or bacteria, which is something we specialize in. That they— they basically get laughed at and say, “Good luck.” And then, they send them all away, and that’s 95% of the people. I alway ask this question to every new client. When’s the last time you saw a medical doctor? If they have an answer to that question, usually the answer is in a negative way, meaning, “I went to the doctor. I didn’t get the answer I was looking for. Now, that’s why I ended up at your door,” which is crazy because I’m not a medical doctor but yet I’m giving people far better success rates because we’re looking at root causes. We’re not just throwing antibiotics or Diflucan at them and saying, “Have a good day.”

Dr. Justin Marchegiani: Yeah. It’s really interesting how much treatment by conventional medical doctors is driven by acceptance from peers or just maybe uh— you know— what the— the so-called best practices are, right? The problem is, in conventional medicine, it takes 20 years to get research into the curriculum, so there’s— It takes so long for these people to even interject new information. I mean, you go into conventional dermatologist office— you know— they’ll— we’ll have the typical handout that even says, “Diet does not affect skin, or breakouts or Acne.” But we know that diet is a massive direct cause. Anyone that’s changed their diet will notice their skin probably clear up the first time. So, it’s interesting as functional medicine docs were really driving our protocols and our treatment based on results. Non-dogmatic, let’s get the patient better. The results are what matters. We don’t need to wait ten or 20 years for a research study to tell us we’re on the right track.

Evan Brand: Agreed. Yeah. My wife, I mean, she had so many skin issues and it was all tied into probably a Candida problem but her skincare  products too. And people will say, “Well, is this a tangent that you’re going on?” “Yeah. a little bit.” And it’s because I want people to think about the other pieces of this puzzle. So, it’s like if you just focus on the Yeast, you’re probably not gonna get the results. Like, you could take all the Oregano oil, all the Olive leaf, all the Caprylic acid that you want. And you may fix some of the issue, but for me, I had parasites and H. pylori, which is a bacterial infection. I don’t think many people have talked much about H. pylori so I guess let’s give the— the audience a little bit of info about it. Uh— It’s a bacterial infection estimated 50% of the world’s population has H. pylori, and what it does is it damages the poridal cells in the stomach, which secrete HCl, Hydrochloric acid, which is your stomach acid. And, what that causes is the stomach to become more alkaline so the pH is increasing, meaning, now, you can’t digest your proteins. So, your grass-fed beef and your pastured meats and your chicken, and all these good things that you’re eating, you can no longer digest those. So then, you get rotting and putrefying food in the gut, which then creates a leaky gut situation that creates fermentation, which feeds bacterial overgrowth, which then feeds Candida. So, all that being said, you can still fix the gut, have terrible skin care products and then have terrible skin, which is what my wife had. She was basically covered in Hives and she went to like five dermatologists. And guess what? They all just gave her steroids, and she put the topical steroid on, and then it would get better for a week and then it would get worse again. And so, we knew something was up in the gut and then we knew something was up externally. We cleaned both parts up, and then all the sudden her skin’s been perfect. And [crosstalk] me too.

Dr. Justin Marchegiani: That’s great.

Evan Brand: I mean, uh— probably, maybe 2013/14’/15’ whenever it was. Several years ago, when you and I first started talking together, you were like, “Man, I bet something’s going on in your gut ‘cause I was having breakouts on my chin, and no matter what I did, my diet was super clean.” I think I did have some roll of cheese in there and I did have to pull out raw dairy, unfortunately. Luckily, I do butter now and that’s my only source of dairy. So, I do okay with butter, but cheeses, they had to go. And you’re like, “Look, man. I bet something’s going on food-wise or gut-wise.” And you were right on both counts. It was the roll of cheese, even though it was grass-fed, hand-picked by the Amish in the beautiful field on the mountaintop. No.

Dr. Justin Marchegiani: [laughs]

Evan Brand: I don’t know. It was— you know— It was the highest quality I could find, but it didn’t matter because I had gut bugs. And— And that dairy, that undigested Casein proteins, not only was it addicting because it’s similar to Gluten, where it’s addicting. You get these Morphine-like compounds. You hit the Opiate receptors with undigested dairy and Gluten. So, those had to be pulled out of the diet for the addictive property reason, but then also, it was feeding the Yeast that I had.

Dr. Justin Marchegiani: Totally. That makes so much sense. And you know, big thing that I noticed too growing up, I had lots of Yeasts. I mean, I had Chronic Athlete’s foot. I mean, I would literally remember like in bed, like being like 8:00/9:00/10:00, and I would like scratch my toes. I’d like take on etoe and like scratch the top of the other toe until I bled.

Evan Brand: Mm—

Dr. Justin Marchegiani: Remember, I was just chronically doing that throughout my whole childhood.

Evan Brand: Was that antibiotics or what let to that for you to be so young and have Yeast?

Dr. Justin Marchegiani: I mean, I think it’s just a combination of antibiotic usage, like Chronic Ear Infections. Literally, six or seven every year by the way, since I have cut and cleaned out my diet. I’ve had zero ear infections for 15 years. And I’m in like Austin every week, water skiing and I have but all kinds of potential bacteria getting in there, not any ear infections at all. So, that’s a huge component. The other one, is I had a ton of Rosacea growing up, and I find Rosacea and fungus has a massive correlation. You cut out Rosacea, and Rosacea just like— when your skin just gets really red and flushed. And when I cut— you know— clean the diet up and cut the fungus out, I noticed the Rosacea significantly improved.

Evan Brand: Yup.

Dr. Justin Marchegiani: [crosstalk] I know if we go back to some of your pictures or videos from a couple of years ago, you can see your skin had uh— a more reddish hue and you can see that’s cleared up too.

Evan Brand: Yeah. [stutters] It’s definitely much, much better now. I still occasionally get a pimple here and there, and it’s probably ‘cause I touch my face. If I touch my face— you know— if I’m sitting here thinking I’ve got my hand on my cheek or my chin, or something. But, I’ll tell you, man. My skin is probably 90% better.

Dr. Justin Marchegiani: Yes.

Evan Brand: And it was already 100% better from when I was a teenager. So, like I had exponentially increased my skin health and I still had a little bit of Acne and I just accepted it as normal. And see, I think that’s something I want to kind of divert the conversation to, is that many people accept their condition and they modify their lifestyle to appeal to that condition. So, if you have back pain, maybe more sedentary because you don’t want to hurt your back. So, you don’t exercise. If you have depression, maybe you don’t go out in public because you’re depressed and you don’t want to make friends. If you have anxiety— I had a woman as a client who— she didn’t drive on the highway because everytime she got on the highway she would have panic attacks. And, so many people modify their disease or women, they get Acne and their face is covered in Cystic Acne and bad deep— you know— the Pizza Face, they call it. But they just put more makeup on. And, they’re modifying their lifestyle— more makeup. They’re avoiding social situations. They’re— Or think about belly fat— you know— with Candida. So many women are concerned about their weight. So, uh— I don’t want that topic to go uh— ignored. If you have that Candida belly, that big doughnut belly, they’ll just put on black clothes or they’ll put on a flowy dress instead of a tight dress. And then, they don’t feel sexy. So, it’s like, “Look. Stop sabotaging yourself. If you just get to the root of all this, you don’t have to wear as much makeup. You don’t have to wear black. You don’t have to wear a flowy dress to hide the belly. Like, you can fix all of these issues.” And for me, I never wear makeup, but I got to the point where I thought, “Okay. This is just Evan. I just em— I’m just a guy who’s gonna have  X amount of Acne always on my face.” Nope, not anymore.

Dr. Justin Marchegiani: I love it, man. So much value. I listen to so many summits and so many people they just talk about flaw, flaw, flaw. And you listen to someone for an hour, and you’re like, “Okay. I heard a lot of stuff, but like, what’s the take-home? Like— Like, what am I gonna do now?” And then you— you walk away, being like kind of paralyzed. “Okay. I heard some stuff, but what the heck do I do?” So, off the bat, just kind of summarizing, we know that Candida and— and this type of fungal overgrowth have massive effect on the skin. We know it has effect on the immune system through leaky gut. As you make the gut more permeable, food can get into the bloodstream and create autoimmune issues. We know that the Acetaldehyde can make its way up to the brain and create mood issues, also become a stress on the liver. And then also, it can create other toxins, like Salsolinol, and we know that energy issues as well because— Let’s talk about that. This— Doesn’t Candida also uhm— eat up a lot of B vitamins too?

Evan Brand: Well, I would say, Candida plus the other bugs too, right? Because as we mentioned in the beginning, it’s rarely Candid by itself. But, yeah. If we want to just simplify, yeah, you could say Candida. But everytime we look at Organic acids panel, almost always, there’s some levels of B vitamins being low. Whether…

Dr. Justin Marchegiani: Yeah.

Evan Brand: …it’s B2, which is the Riboflavin, whether it’s your B6, which is important for converting Serotonin into Melatonin…

Dr. Justin Marchegiani: Yeah.

Evan Brand: …which is why so many people have sleep issues, because the Candida’s rob them of their B6. Now, they can’t convert Serotonin. So, even if they take 5-HTP to have— try to help sleep and Serotonin, if they don’t have the B6 component, they don’t sleep well. So, yeah. B vitamins get robbed. We talked about amino acids being robbed. Talked about neurotransmitters being low. And, just the fact that you feel like crap when you have Candida because then you’re driven by sugar cravings. I mean, I’’ll tell you, I remember the point where I couldn’t go more than a few hours without eating. And, there’s an adrenal component to that too, which I think we should mention and address here. Which is that, when you have gut stress, which could just be Candida or could be other bugs, your adrenals are stressed because the liver is stressed and the adrenals have to come in to try to pinch hit, as you call it, to help out the liver. So, the adrenal glands get involved. You’re secreting Cortisol, and that Cortisol is further affecting blood sugar ‘cause then the pancreas has to get involved. So, that’s just whole system of pancreas, adrenals and liver. If there’s liver stress, the adrenals have to come in.

Dr. Justin Marchegiani: Right.

Evan Brand: If there’s adrenal stress, the pancreas has to come in and try to help out with Insulin regulation. So, long story short, I was a mess. I was a triangle mess. I had pancreas, therefore blood sugar problems, liver problems, therefore detox problems. I was getting headaches all the time. I was exhausted. And then, adrenal problems. I had heart palpitations. I had problems falling asleep, problems staying asleep. And, it was this whole triad, and it all stemmed from the gut. So, long story short, uhm— uh— I told you before we jumped on this cause that, “Hey. Let’s make sure that we talked about putting together a Candida protocol…”

Dr. Justin Marchegiani: Yes.

Evan Brand: “…for somebody.” So— So, let’s talk about that.

Dr. Justin Marchegiani: So, hold on. I mean, just, yeah. [stutters] I think that’s the End stage…

Evan Brand: Yeah.

Dr. Justin Marchegiani: …but let’s go a little bit deeper to how to figure out you even have Candida to begin with first.

Evan Brand: Okay.

Dr. Justin Marchegiani: So, I’ve been…

Evan Brand: Okay, good.

Dr. Justin Marchegiani: I’m gonna— I’m gonna pitch you over of kind of the lab test that you do— we do to detect this stuff. But, we have some clinical symptoms, right? We have Tinea versicolor, which is kind of like a fungal rash. You can just do a Google image of it, and you can get a sense of uhm— what that looks like. Again, Google image will give you the most severe [laughs] pictures and tends to be in the worst body parts, on Google, but uh— at least it gives you a pretty good idea. You have, obviously, Jock itch, right? You have uhm— uh— Tinea capitis or— or Cradle cap, or uhm— Seborrheic Dermatitis, right? Those dandruff— those type of things. You have Athlete’s foot. I mentioned the Jock itch. Uhm— Those are gonna be like your big clinical indicators on the skin. You have Thrush or just uh— a gentle white coating in the mouth or on the tongue. I’d say, those would be some of the— the key clinical indicators, things that you physically see in an exam outside of labs. Is there anything else, clinically, that you wanted to add there?

Evan Brand: I would say the fingernails, right?

Dr. Justin Marchegiani: Yep.

Evan Brand: My fingernails…

Dr. Justin Marchegiani: Oh, yes.

Evan Brand: …showed up with itch. The fingernails— So, could be little white spots, like little white flex but could be vertical ridging, vertical lines. And I can actually feel it’s much, much better than it used to be, but I can actually feel the vertical ridges on my nails. So, guys, look down. Girls, look down. If you have fake nails, take them off. Look at your ridges. [crosstalk] If you have vertical…

Dr. Justin Marchegiani: [laughs]

Evan Brand: …ridges, uh— that’s a sign you’ve got Malabsorption.

Dr. Justin Marchegiani: Absolutely.

Evan Brand: You’ve got to figure out why. You got to figure out why. Is it Candida? Probably.

Dr. Justin Marchegiani: And I think you also want to mention is that slight yellowish hue on the fingernail or on the toenail, and that’s super helpful too. We can talk later about how we address that, ‘cause sometimes, those will not go away even with the diet and the gut stuff because it’s so far removed from the body. But, we’ll add that to the end. Alright, good. So, we hit the clinical indicators. Let’s go into the lab tests. I know, there’s a couple different body secretions you measure, uh— Urine with Organic acids, Stool with some of the gut testing, and also, maybe you even do blood, too. But, let’s go break that down.

Evan Brand: Yeah. So, the Stool Testing, for Candida specifically, it’s not very accurate, and I actually uh— We talked about this a little bit uh— during Kailash’s interview. He kind of brought something interesting up, which I’m gonna go ahead and just mock what he said ‘cause it makes sense and it seems to correlate with the symptoms. It’s that, when he sees that the Stool test doesn’t show Candida, but it does on the Urine, that he considers it a much worse overgrowth, which I think is— is seems kind of counterintuitive. It’s like, “Okay. The Stool missed it, which it commonly does, but then the Urine finds it.”  thought, “Okay, that’s just Candida.” But, he’s saying, he thinks when the Stool doesn’t find it at all, then it’s more systemic. Therefore— It’s not showing up in the Stool ‘cause it’s more in the bloodstream, and therefore it’s a worse overgrowth. So, I thought that was a cool little caveat that I’ve added to my— to my brain because, most of the time, 95% of the time, the Candida shows negative on the GI Map Stool Test, which is what you and I utilize. But, the 95% of the time that it doesn’t show there, it does show on the Urine Organic Acids Panel. There’s a whole section dedicated to Yeast and Fungal markers that we look at. There’s Carboxy Citric acid.

Dr. Justin Marchegiani: Yeah.

Evan Brand: There’s Citric acid. There’s d-Arabinitol or d-Arabinose, which is the gas that Candida produces.

Dr. Justin Marchegiani: Yeah.

Evan Brand: You’ve got Tartaric acid, which…

Dr. Justin Marchegiani: Tartaric.

Evan Brand: …is another one.

Dr. Justin Marchegiani: Yep.

Evan Brand: And, we look at these and that’s like measuring the tailpipes. So, when you take your car in for Emissions testing, we’re measuring the tailpipe of your body, which is the urine. And we’re saying, “Hey, look. Here’s the metabolite. Here’s the breakdown product.” Meaning, Candida’s in there and it broke down into this organic acid, and we found it in the urine. So, there’s your 100% proof that it’s there.

Dr. Justin Marchegiani: Love it. That is absolute knowledge bomb. So, I do like that. I do see the d-Arabinitol, like on Organic Test. Uhm— It’s a really good indication of systemic because it’s looking kind of, metabolically, what’s happening throughout the body, especially if we miss it in the gut. I had about four patients this week, where it missed it in the— the Gut Test, but then it came back in the Urine Test. So, that’s good to know. I also see other types of Yeast in some of these testing, like Microsporidium or Geotrichum. What’s your experience with other types of Yeast outside of Candida? Do you feel like Candida is the more viral or invasive species? What’s your take?

Evan Brand: Well, i would say, Candida’s definitely more common.

Dr. Justin Marchegiani: Yeah.

Evan Brand: And, I do see the Microsporidia, which is— It’s funny ‘cause it’s in the fungus category, but when you do a research on it, it comes up being a parasite, too. So, it’s almost like it’s a parasite and a fungus. I don’t know. It— Microsporidia is a weird one. Do you have a comment on that?

Dr. Justin Marchegiani: Yeah. I mean, I would say that people that have Yeast issues, uhm— tend to be more Candida-based, and I know Candida albicans is the one that’s been researched the most. But, you know, if we see another type of Yeast like a Microsporidia, we’re gonna treat it just the same. I don’t really…

Evan Brand: Yeah.

Dr. Justin Marchegiani: …alter my Yeast programs any different. We’re gonna still knock it out.

Evan Brand: Agreed.

Dr. Justin Marchegiani: And— you know— I see a lot of these Yeast issues combined with H. pylori, and it makes sense ‘cause H. pylori alter stomach acid. What are your thoughts on that?

Evan Brand: Oh, yeah. I mean, it’s huge. That’s what I had, right? That’s kind of what I was mentioning earlier. It’s that when the H. pylori does the damage to your poridal cells, you’re not making stomach acids. So then, the food rots and putrefies, and that fermentation process in the gut feeds Candida, where a normal commensal amount of Candida becomes an overgrowth level. So, yeah. I would say, in— in the order of dominoes, like chicken or egg, I would say, h. Pylori could absolutely come first and then Candida overgrowth could follow. And, same thing with Proton Pump Inhibitors. Let’s just take the H. pylori out of the picture and say somebody that was put on an acid-blocking medication because they had heartburn. That would also lead to a pretty systemic Yeast overgrowth. And, I second your thoughts— the Geotrichum, the Microsporidia— these other type of Fungi and Yeast that we see. I don’t modify the protocol at all because a lot of the herbs that are used for these protocols, they’re pretty cool. They’re pretty comprehensive. They’re gonna knock out parasites, bacteria, yeast, kind of all in one fell swoop. So, really don’t have to do something different if we see Candida plus Geotrichum. It’s something that we can just keep the same. We just want to— we want to “test, don’t guess,” which is the whole philosophy behind this. It’s, “Look. maybe you’ve got all those symptoms, but wouldn’t you rather test yourself first with these functional medicine test that we’re talking about rather than building up your supplement graveyard even further and buying supplements that you’ve heard but you don’t really know if you need them? And, now, herbs are a thousand times safer than antibiotics but it is true that we can kill some beneficial bacteria in the gut, especially in like really, really young kids and toddlers and infants, where their immune system isn’t formed. You might not want to throw a bunch of heavy Oregano oil at a two-year old kid that we’re working with. So, get the test first, because then you’re gonna be much more specific in terms of the— the options for the treatment.

Dr. Justin Marchegiani: Phenomenal. Excellent. And then, I noticed, when people find out they have some type of critter of foreign uh— entity inside of their— their digestive tract, they want to knock it out right away. And I find so many people, they’re going after gut issues, but they haven’t had the foundational things in alignment. They haven’t had the— the hormonal uhm— support, the nutrient support and the anti-inflammatory support on-board. Then, they go after these critters. They start feeling worse. Can you talk about how you sequence care or treatment when you go after these gut bugs, especially Candida?

Evan Brand: Yep. Well said. And uh— first, I just want to give credit where credit’s due. You know— I thank—I thank you so much for all the mentorship that you’d given me over the last several years because a lot of this education, I had to learn the hard way. And that was by you helping me to create my own protocols to work on myself.

Dr. Justin Marchegiani: Uhmhm— Uhmhm—

Evan Brand: And then, I took that knowledge that you’ve taught me and put it into my clients. So…

Dr. Justin Marchegiani: That’s great.

Evan Brand: Just want to— to pause and say, “Hey, look. You’re the man. Uh— Thank you.” And regarding the— the level of care that you’re providing and the order of care that you’re providing, that’s huge. If you go to a quote/unquote “gut expert,” they may just focus on just the gut. If you go to just a Lyme disease expert, you’re gonna get diagnosed with Lyme and every issue that you have is related to Lyme.

Dr. Justin Marchegiani: A hundred percent.

Evan Brand: Headaches? It’s Lyme. Fatigue? It’s Lyme. Joint pain? It’s Lyme. And it may not be. It may be Rheumatoid arthritis caused from a Prevotella infection, which is an autoimmune trigger that we see, or a Proteus mirabilis infection, which is a bacteria that we see, for example, in Rheumatoid arthritis patients. You can look at the research on this. Seventy-five percent of people with new Onset Rheumatoid arthritis have a Prevotella Infection, which is an autoimmune trigger that you and I see on Stool test every single…

Dr. Justin Marchegiani: Also—

Evan Brand: …week.

Dr. Justin Marchegiani: Also, the Mycoplasma infection, too.

Evan Brand: Yeah, Mycoplasma, which my wife had, and…

Dr. Justin Marchegiani: Yes.

Evan Brand: …she had bad joint pain from. So, long story short—

Dr. Justin Marchegiani: And when we knocked the Mycoplasma out, what happened to her joint pain?

Evan Brand: Her joint pain’s gone.

Dr. Justin Marchegiani: Gone. That’s it.

Evan Brand: See, she’s so much better. So, he point I was getting at here is that— you know— you and I, what we do is— is kind of like a specialty in it’s own. Right? Like, functional medicine and the type of functional medicine that we’re creating and using with our clients is very, very specialized, but at the same time, we’re generalist in the sense that we’re not gonna say everything is Lyme. We’re not gonna say everything’s your gut. We’re not gonna say everything is the thyroid, if you’re a thyroid expert. Or, if you’re an adrenal expert, [clears throat] we’re not gonna say everything’s adrenals. We have to look at all of it, and that’s something that uh— I— you know— I really credit to you teaching me that, because if you go too hard into a gut protocol, what happens is you start to get more fatigued. You may have die-off reactions, or Herxheimer reactions, which in my opinion, like the longer I do this I’m starting to believe that Herxheimer’s are— are like a myth. Or, not a myth, but that it shouldn’t happen. Like, if you design a good protocol, which would involve supporting the adrenals, sometimes we have to support the adrenals for a month before we even go into the gut protocol. If that person is too weak, the last thing you want to do is start a war. Like, I mean—

Dr. Justin Marchegiani: Yeah.

Evan Brand: Uh— Uh— You know—

Dr. Justin Marchegiani: Totally.

Evan Brand: You have— You have such great analogy so let me try to— to mock your skills with this.

Dr. Justin Marchegiani: [laughs]

Evan Brand: You know— If we’re going into the Civil war and we’ve got— you know— 50 guys on the Confederate side, and we’ve got— you know— 5,000 guys on the North, that’s— that’s a not— That— That’s a— That’s uh— If you’re the Confederates, you’ve got a bad chance of winning if you’ve only got 50 guys left and then the North has 5,000. Like, you’re toast. And so, why would you want to go into battle against those guys until you’ve built up your reserves. So, in this analogy, building up your adrenals are the reserves. You’ve got to have the adrenals, the backup generators for your energy production to come in and rebuild your army. So then, you can go into battle  when it’s a more fair battle. Once the army’s strong, once the adrenals are on-board, and we’re supporting that with the use of adaptogenic herbs, things like Ashwagandha. I’m a huge fan of Albizia bark, which comes from the…

Dr. Justin Marchegiani: Uhmhm—

Evan Brand: …Mimosa tree. Uh—

Dr. Justin Marchegiani: Oh!

Evan Brand: Yeah, I love it. Motherwort.

Dr. Justin Marchegiani: …came from Mimosa? Oh, that’s cool to know.

Evan Brand: Yeah. Uh— Motherwort is been a huge favorite for me. Blue Vervain has been something I’ve been using a lot the last couple months. And, then of course, our standards that many people talk about— Reishi mushroom, Cordyceps mushroom, Rhodiola can be great. Be careful if you’re Bipolar Manic depressive. Rhodiola can exacerbate it.

Dr. Justin Marchegiani: Okay. Good to know.

Evan Brand: Uhm— Schisandra— Love Schisandra berry extract. There’s also— Oh, God! What else could I mention? Eleuthera, which is Siberian Ginseng. Licorice, I use not too commonly because a lot of people have blood pressure issues and Licorice, long-term, could elevate that just a bit. I play with Licorice, but for me, it’s personally too stimulating so I don’t use much of it.I focus more on the— the other herbs. And you know— especially because so many people on our society are fatigued, but they’re tired and wired and they have anxiety. So, that’s why I generally start with the more calming things, like the Albizia, the Sisyphus, which is a seed. [crosstalk] Sisyphus seed is very cool.

Dr. Justin Marchegiani: That’s what I’m gonna say.

Evan Brand: Yeah, ain’t it?

Dr. Justin Marchegiani: —this. Right.

Evan Brand: Uhm— M— Motherwort, which is cool, and— and then the Ashwagandha, which I do pretty much everyday. Uh— I pretty much stay on adaptogens and— and Kailash kind of called me out. He goes, “Well, you’re cheating. You— You need to fix your lifestyle.”

Dr. Justin Marchegiani: Oh. Right there. Ashwagandha, baby. Love it.

Evan Brand: Good. Kailash is like, “Evan, you’re cheating, you know, because you’re just taking the adaptogens.” And— And then, I said, “Well, I’ve got a little baby at home.” And he goes, “Oh, okay. Well, that’s just special circumstance. You deserve the adaptogens.” I was like, “Okay, good.” Uh—

Dr. Justin Marchegiani: [crosstalk] I think the adaptogens are great. There’s a lot of long-term research on that. You know, Dr. Stephen Buhner  talks about Ashwagandha’s being one of those adaptogens that you can take long-term, which is great. I love that.

Evan Brand: Yeah. And it’ funny though ‘cause he called me out, and he’s like, “Evan, you’re just using that as a crutch so that you can work five days a week when you should only be working three days a week, you know.” Uh— So, that was funny. And— And I agree, but you and I, we love the hustle. We love the grind. We love helping people. So, uh— I’m so driven that I used the adaptogens to help keep me going. And, I do have a baby at home, and she wakes us up at night. And my sleep pattern, my Circadian rhythm is not perfect. So, I use the adaptogens in that manner. But, back to the story of Candida, adrenal support always should be on-board because it is a stress. Now, it’s a good stress, but still stress to kill off these gun infections. So, that’s why adrenals need to be on-board. And then, we spoke about the liver support too. So, if we were kind of piecing something together, like step one-two-three, or maybe options one-two-three, A-B-C, that should be in— in place, I would say, adrenals is at the top…

Dr. Justin Marchegiani: Yup.

Evan Brand: …and secondly is the gut support. And then, usually, the gut support has liver support added. And then…

Dr. Justin Marchegiani: Yup.

Evan Brand: …inside of that, we could also talk about some Mitochondrial support.

Dr. Justin Marchegiani: Yeah.

Evan Brand: If we see that there’s Mitochondrial dysfunction, we could do Creatine, Ribose, Carnitine, CoQ10…

Dr. Justin Marchegiani: Right.

Evan Brand: …PQQ, other nutrients to fuel Mitochondria…

Dr. Justin Marchegiani: Yup.

Evan Brand: …so the energy levels can hurry up. Now, if you support adrenals, you support liver, you’re giving like N-Acetylcysteine, Milk Thistle kind of take in the load off the liver, you can start producing more Glutathione from your liver on your own to help detox improve, but we may need to throw an extra detox support. So, you and I talked a lot about the binders, like the— the clays, the charcoals, the stuff like that to help pull stuff out. We’ll go back to the war analogy. If you’ve got the— the field— And I think Kailash use the same analogy, but something along the lines of if the— if the battlefield is full of all these dead bodies, all these dead bugs, but you don’t support the liver and the gallbladder to get the— the dead bodies out of the field, you become overburdened. So, it’s kind of like, maybe if you had a water hose but the golf ball was stuck at the end of the hose, and then you turned on the hose, which  is you killing all the bugs and trying to flush them out, but the detox and drainage pathways are— are toast and they’re not open at the— at the end of the hose, it’s not gonna work. And then, you start like feeling worse. And then, your practitioner says, “Oh. Herxheimer reaction is good. You’re getting better. Keep pushing forward.” It’s like, “No, no, no. I disagree.” I think that means something’s overburdened. You’re too weak. You’re creating too many toxins. You can’t keep up. You need sauna, or you need an Epsom Salt Bath. Or, you need something, or you need to take less herbs, or less intensity, or you need to shorten the duration of the herbs. If your body is screaming at you, saying, “No, no, no, no, no,” don’t keep pushing forward. That’s silly. That’s like being on the train of going across the bridge and then the track like disappears. You know— It’s like…

Dr. Justin Marchegiani: A hundred percent.

Evan Brand: I want to make sure.

Dr. Justin Marchegiani: Yeah, 100%. And, just to kind of echo a couple of things that you just said. Number one, if we have a lot of infectious debris inside of our gut that we’re killing off, that could easily overwhelm our body. So, if we sequence care the right way, with the adrenals and all the diet stuff first, that’s gonna reduce inflammation. And when cell— When you you have less inflammation, cells don’t stick together as much. They don’t uh— glutinate, so they can move in the Lymphatic system  better, and move out your body. And think of the Lymphatic system as— It’s the interplay between the blood and the tissue so, as things die, we kind of have to get them into the— you know— if we— they go into the blood. They go into the Lymph. And, ideally we excrete them out, whether it’s stool or in our— you know— typically Stool or in our Urine. So, we have to make sure those pathways are moving but the more inflamed we are, the more the cells stick together, and they glutinate and become really stagnant  and sludgy, and that increases stress on our detoxification pathways. And the longer those toxins are there, it stresses out our immune system. So, one of the things I wanted to highlight in them will go back to treatment issues. There’s a lot of patients, they come in there and they kill things out too fast or too hard. So, my instructions to patients is, “Go taper it up. If you have a lot of die-off issues,” and a lot of times it’s gonna be Fatigue, Malaise, Achy Joints, Headaches, or just an intensification of the symptoms you already currently have. You either, number one, slow down, decrease the dose, take the herbs with food. If it’s really bad, we do a supplement holiday for half a week to a week, add it back in. Throw some ginger and binders in. And, I always just tell patients, “Make sure you can tolerate.” If there’s a tiny bit of die-off and it’s not affecting your life, fine. But if not, you got to follow that die-off reaction protocol to calibrate the dosage and add in more binding support. What are your thoughts on that?

Evan Brand: Yeah. I think it’s excellent. And, so many people that we work with, they’ve already been to 20 practitioners before they  get to us. So, generally speaking, they’re pretty sick. So, you and  kind of have to tiptoe sometimes with people, and that’s fine. It takes a little bit of work. It takes extra brain power for us to tiptoe and handhold these clients, but look. If you’re listening to this, I’m guessing you’ve already done something and it hasn’t worked, which is why you’re here listening to us. And, you know, between the two of us, we’ve worked with thousands and thousands of people at this point. So many that we’ve lost count. And what I’m finding is that people are— are sicker and sicker, that are coming to us and we have to— we have to babystep this. And for me, I’m pretty sensitive, so if somebody tells you, “Take four capsules of something,” that’s the full dose, I’m gonna start with one. And, I’m gonna stick with one capsule for a few days, and then maybe on day three or four, you bump up to two capsules. And you stick with that for a few days, and then you go up to three.

Dr. Justin Marchegiani: Yes.

Evan Brand: And then, maybe two weeks later, now you’re at the full therapeutic dose. I tell people that— I say, “Look. You’re not gonna get a trophy if you get to the full dose right away.”

Dr. Justin Marchegiani: Right.

Evan Brand: You’re not gonna win. You— You’re not gonna…

Dr. Justin Marchegiani: Hundred percent.

Evan Brand: I’m not sending you anything in the mail. I’m not sending you any Gold bars or Silver bars because—

Dr. Justin Marchegiani: [laughs]

Evan Brand: …because you got to full-dose on day three. Like, “Look. Take your time. Start with the adrenals. Get yourself feeling strong. Get your sleep dialed in. Make sure you’re going to bed. If you’re listening to this at 2:00 A.M., shut down the computer. Get off your phone, and go to bed. Come back and listen to this in the morning.” Like, you’ve go to have sleep dialed in. I don’t care how many adaptogenic herbs you take. If your sleep is crap, it’s gonna be tough to heal. There’s a lot of detox and other things going on in the middle of the night that you just can’t do if you’re— if you’re up all night and you’re overworking. So, if you’re working 70 hours a week, you’ve got to fix that first. I talked to a guy yesterday, who’s a Real Estate Salesman, and he’s been fatigued for ten years. His wife was on speaker phone with us so it was kind  of like a three-way conversation.

Dr. Justin Marchegiani: Uhmhm— Uhmhm—

Evan Brand: And uh— And— And she says— you know, “He comes home. He eats dinner at 6:00, and then he’s passed out on the couch at 6:30.” And— And she goes, “And it’s not a light sleep.” She goes, “This full sleeping for three hours, and then he gets up at, you know, 9:00 or 10:00 o’clock. And he crawls into bed.” I said, “Oh, man.” You know, “How long is this thing going on for?” And she says, “Ten years.” This guy’s been working 75 hours a week for  a decade. I said, “Man, when’s the last time you took a vacation?” He goes, “I have no idea.” And then we— you know— talked about sex drive. Of course, sex drive is gone, which usually happens with gut issues, but with that amount of stress. I’m like, “So, do you guys— you know— Do you have a relationship? You know, sexual relationship?” He’s like, “Once in a blue moon.” And of course, they’re both not happy about that. I’m like…

Dr. Justin Marchegiani: Yeah.

Evan Brand: “Why don’t you guys just schedule a two or three-day weekend away somewhere? Why don’t you guys take a trip somewhere and try to get that spark back in your life?” And then, “Look, man. Why don’t you hire a couple admins to help take off some of the load? Like, you’re doing all these paperwork and stuff. Surely, you can— You can offload some of this to somebody so you can do only the expert task.” And he’s like, “Oh! What a great idea!”

Dr. Justin Marchegiani: Yeah.

Evan Brand: And also like, this is the more practical stuff that I think people need to consider when they’re working on this protocol because everyone’s busy. And, if you’re so busy, you can’t heal. And, that’s why I’m taking the entire month of June off. By the time people are listening to this talk, this is gonna be in July, and maybe you and I’ll— uh— we’ll chat and you’ll say, “Evan, you’re crazy. Maybe you only need two weeks,” and I may come back on the clock. But, the goal is at least a few weeks off, just because I want to try a full reset and see. “Okay. If I’m fully disconnected from the emails and— you know— the client care, what does that do for me?” So uh— So, I’m gonna try it. So, long story short, if you have stress, you have relationship issues, you’re working too much, plese address those issues, as well as address the protocol stuff.”

Dr. Justin Marchegiani: One hundred percent. I love it. And anyone listening to this, make sure you subscribe right now. Go over to, C-A-N-D-I-D-A-S-U-M-M-I-T. We’ll put the link below. We’ll put some annotations on screen here. Make sure you subscribe because this is gonna be one interview out of 30, and I’m— I’m so pleased that i had the honor to interview you ‘cause it’s your summit, and it’s just great that you are actually contributing to your summit. It’s amazing, I know, but you’ll probably provide some of the most valuable information, ‘cause especially when it’s happened to you and you’re connected to it, and you see improvements— I mean, how can you not be incredibly passionate about it?

Evan Brand: Agreed. I know. I feel like you and I could chat for three hours but we said we probably want to make it short and sweet, because then we give too much information and people have no clear action steps. So, I just— L— Look. here’s the deal, too, for people listening. We spoke about this on— on Dr. J’s interview on the Candida Summit as well. If you like what you hear, our interaction or rapport that we have together, our conversational tone. We make functional medicine fun. That’s like our tagline. McDonald says like, “Billions and billions served.” You know, open a box of happy or whatever, something crazy. Anyway…

Dr. Justin Marchegiani: [laughs]

Evan Brand: We  make functional medicine fun. So, if— if you like what you’re hearing, this is only just a snippet of what we discuss. So, please look up Justin, Justin Marchegiani. Check him out. He’s the man, I’m telling you. This guy has changed my life more than anyone over the last five years. Uh— I’m— I’m so— you know— [stutters] indebted and so grateful for— for friendship and relationship. So please, go look him up. Go study him. You know, subscribe on his YouTube, if you’re not already. Subscribe to the podcast. And him and I chat pretty much every week so make sure that you’re tuned in because this is just the tip of the iceberg today. And, then obviously, make sure you’re signed up for my podcast as well. And, you know, like, “Okay. I’m here for the summit. Why are you talking to me about this?” We’ll because, look. You’re not just gonna hear this talk and magically everything’s gonna get improved in your life. This takes time. This takes repetition. Just like you’re in the gym, you’re not gonna go hit biceps once and then your arms look like Arnold Schwarzenegger. You’ve got to come back every week to the gym. So, if you come back every week to us and you’re finding one other little new ones golden nugget that you can add into your health protocol, that’s what it takes. It’s repetition. Repetition. Repetition. Apply. Learn. Apply. Learn. I could care less if you’re impressed by the brain candy if you don’t act on it. So, that’s the secret. That’s why I want you guys subscribed to my Evan Brand podcast and Justin’s podcast because I believe you need a partner, an accountability partner, where you tune in once a week or once a month, whenever you can and you get the knowledge and then you apply one little baby step. Maybe it’s you changed your job. Maybe it’s you get rid of the toxic person in your life. Maybe it’s you cut out the— the—  the Gluten-free brownies that you’re eating, or you stopped the Kombucha per— you know— for a little bit because maybe you’ve got excess fermentation, and the Kombuca makes you feel worse but you didn’t know it. You know— That’s the golden nuggets that we might not talk about here but that can give you the significant improvement that you need.

Dr. Justin Marchegiani: That’s phenomenal info, and I appreciate the— the flattery. That is very kind, and flattery will always get you everywhere with me, Evan. Just so you know.

Evan Brand: Uh! [laughs]

Dr. Justin Marchegiani: [laughs]

Evan Brand: Well, hey look. I got— I got to keep it real, you know. And, like I said, there’s— there’s a million uh— people out there that the— that I could learn from, but— but you have a really good way of taking complex things, breaking them into simple actionable steps, and that’s done so much for me personally but clinically as well. So, you know, uh— uh— I like tooting your horn but I’m serious, man. I really, really appreciate it.

Dr. Justin Marchegiani: Well, you’re welcome. And anyone listening to the summit, make sure you go over to, because this conversation doesn’t end just with the Candida Summit, and there’s a lot of other topics that we’ll get into down the road. And, I want to just kind of pivot here to some of the herbs and the antimicrobials that you’re using. I know you kind of alluded to some earlier. I really want to lay it out, but I also want to put a caveat for listeners. It’s really easy to be like, “I got this bug. Let me just hit these herbs.” we kind of already gave you some caveats earlier, but just kind of remember. It’s gonna be always better to have a complete program set up, especially if there’s already hormonal stressors or detox stressors or maybe diagnosed autoimmune issues. You really want a comprehensive program but tie it in. So, with that caveat— and again, Evan’s available internationally, worldwide. I am as well. So, if you want to dig in deeper— you know, we’re gonna be some great guides or Sherpas, so to speak, to help you get to the top of the mountain. But, Evan, let’s just talk about some of your favorite herbs that you used and how you sequence them. I know you have some that you formulated as well so I want to go into those too.

Evan Brand: Cool. Yeah. So, like you mentioned, it’s good to have uh— uh— a partner. I mean, we’re biased. We think that we know enough to significantly help you. So, we’re gonna say, “Hey, look. Work with us because we’ve done this a thousand times and our success rates are very high.” “Are there other practitioners out there that could probably help you?” Of course. We’re not against those. We— We’re— We’re for anybody that helps you. I always say, “Look for a practitioner that’s creating content. If they just have like a really pretty smile on their website but they have no content, they’re not regularly producing content, be questionable because maybe they’re stuck and they’re stagnant in their protocols, where every week, you and I are discussing what worked, what did not work? So, that’s the disclaimer. I’ve got two different formulas that I’ve used a thousand times that works so good, called MicroBiome Support II, MicroBiome Support III. These are the formulas that I have that have a combination of herbs. So, these are things like Yoro flower, Hedyotis. Cutch tree, which is a bark, Java brucea, which is a fruit, Wormwood extract, which many people know Wormwood for being an antiparasitic. But, it also can kill gram positive bacteria, which are lot of the bacteria we see on Stool test. Dill seed is in there as well. And then, we’ve got the MicroBiome Support III, which I use for Candida every single day. And the MicroBiome III, this is Olive leaf. This is Stinging Nettle root.

Dr. Justin Marchegiani: Mm—

Evan Brand: This is Pau D’arco, which is…

Dr. Justin Marchegiani: Hm—

Evan Brand: …a bark. Many people can drink pau D’arco bark tea.

Dr. Justin Marchegiani: Tea, yeah. 

Evan Brand: That’s great, but it’s not gonna work as good as a supplement extract. Thyme leaf is in there, French Tarragon leaf, Horsetail herb, and a few others. And this is kind of our antimicrobial/antifungal, because Olive leaf, not only does it help with blood sugar but it helps with viruses, and it helps with fungi. So, I use this protocol pfft— every single week. I told you before we got on the show. I said, “Man, can you believe the combination of herbs and how much stuff you can knock out across the board. So, if we’re talking parasites, bacteria, Candida, all at once, if I run the MicroBiome II and III, six capsules a day— two, two and two, breakfast, lunch, dinner. Of course, we’re doing the liver support, which is gonna be something like my Liver Synergy. If we’re doing an adrenal support, which there’s many variations of that, plus digestive enzymes. We’ve got a really, really heavy hitting 1-2-3-4 punch, and we’re gonna pretty much knock out all the bugs. And die-off reactions are gonna be pretty minimized because we’re supporting adrenals, we’re supporting liver. And then, the herbs that we’re using, they’re potent, but they’re not so potent that they’re gonna make you sick.

Dr. Justin Marchegiani: Love it. I mean, phenomenal information. I mean, where can you get this much information in 45-minute uh— summit interview? So, all the listeners, give us a thumbs up. Give us a share right now. Give us a like. You know, if you— If you’re writing somewhere where you have the ability to put comments, let us know your thoughts. We want to continue to provide better information, and this summit is a— awesome platform to do so. Evan, is there anything else you wanted to add for the listeners here…

Evan Brand: Uh—

Dr. Justin Marchegiani: …before we wrap up?

Evan Brand: yeah. I would say, “Don’t give up.” If you hear that there’s a Silver bullet, be skeptical of the Silver bullet. Like, if somebody says, “Hey. All of your problems are X-Y-Z.”

Dr. Justin Marchegiani: Uhmhm—

Evan Brand: I— I doubt it. I doubt it. It’s always multifactorial. For me, it was adrenals. It was H. pylori. It was bacteria. It was Candida. It was a bad Circadian rhythm. It was working night shift, when I was in college.

Dr. Justin Marchegiani: Uhmhm—

Evan Brand: It was excess stress. It was Gluten that was previously in my diet. It was dairy that was in my diet. It was bad relationships, maybe toxic emotions from certain people I was taking on. It was obligations that I had in my plate that I should have gotten rid of. Like, all that stuff was part of the protocol. So, if you just said, “Evan, it’s Candida,” it would have been wrong because it wasn’t. So, make sure you get a good functional medicine practitioner on your team. Get a good work up. If it’s Justin, awesome. If it’s me, awesome. If it’s somebody else and they still give you the same success rate as us, awesome. I don’t care who it is, but I want you to get better. And, we’re up against a lot. The healthcare system is collapsing on itself right now. But, I believe, with the functional medicine wave that we’re riding right now, I believe we can turn this tide around. And, it’s a— it’s a division of two systems. And I’m not saying, “Ditch mainstream medicine,” like if you— If you break your arm— Like I thought I broke my arm like a few weeks ago, please go get the X-ray and see if your arm’s broken or not…

Dr. Justin Marchegiani: [laughs]

Evan Brand: …and then get help. But, thank goodness, I didn’t break my arm. Justin, help me. He was like, “We were— I was in the back of the car, driving to the— to the Urgent Care.” And Justin’s like, “Hey turn your hand this way. Move your hand this way. Hey, can you put your arm up?” He’s like, “Okay. I don’t think it’s broken, but get it checked out anyway.” So, uh— look. Still do that stuff, but once you found out that your arm is not broken, then you got to get back to the functional medicine world. Check out your Mitochondria. Check out your liver. Check out your gut. Check out your adrenals. Check out your thyroid. If you have autoimmune disease, take this stuff even more serious. Hashimoto’s, etc., Rheumatoid arthritis, if you’ve got Alopecia, if you’ve got Sjogren’s— I don’t care what you’ve got, autoimmune-wise. You’ve got to do the work. Because, you’re not gonna get a magic drug that’s gonna fix your autoimmune disease. You’ve got to address all of this stuff.

Dr. Justin Marchegiani: That is amazing. How does it feel to give the best summit interview in your own summit?

Evan Brand: Hey. Well…

Dr. Justin Marchegiani: [laughs]

Evan Brand: …I think it was pretty good. Uh— It feels good. It feels good. Uh— I don’t ever want to be like an all-knowing guru. I just want to tell people, “Look. I figured out enough to help a lot of people. I don’t know everything. I never will. But, I’ve learned enough to significantly move the needle.” And I’m happy with that.

Dr. Justin Marchegiani: And I think one of the nice things that we’ve kind of— we got a pretty good tag team going, where we kind of feed off of each other, which is great. You help push me up. I help push you up. In the— In the interview and the content delivery process, and that’s— that’s awesome. It creates momentum, and that momentum— You know, the listeners get the benefit from that so we’re really excited. 

Evan Brand: Yeah. I get emails every week. Man, when you and Justin get together, it’s the best. So— I mean, you and I kind of joke. It’s like, “Okay. Let’s just never interview anybody else, except each other, because we have so much fun together.” But then, we may become stagnant. So, we still interview and have a lot of good conversations with other practitioners. But, yeah. Uh— i don’t think there’s anything like the energy that you and I have together. So, once again, thank you so much. Thanks for interviewing me. Thanks for helping me out with this project.

Dr. Justin Marchegiani: You’re so welcome, Evan., subscribe and get all 30 listeners. I’ll be speaking in that as well at Available for consultations worldwide. And again, if you’re on the fence and you’re trying to figure out if you’re a good fit, there are also some introductory consults there, where you can get screened and see if you’re ready for the next step.

Evan Brand: [crosstalk] Yeah. Justin, tell people about uh— you, as well, how people can keep up with you, study you, study your work, etc.

Dr. Justin Marchegiani: So, yeah. Got to uh—, J-U-S-T-I-N-H-E-A-L-T-H dot(.) com. You’ll see my podcast link there. Subscribe my YouTube links. Subscribe. Get on my newsletters so you get all these information right at your fingertips. And if you need to reach out to me, if Evan’s a better fit for you, personality-wise, go with Evan, or go with me if you feel like you’re a better fit. See what’s best for you. The most important thing is it— it’s got to be in alignment with you and health and how it’s in that— you know— That— That way, you’re gonna be the most compliant. You’re gonna be on track. But either way, you can’t go wrong, and I’m so excited to be part of this and make sure everyone just shares it with someone so this information gets out there. Our goal is to help millions of people, and we cannot do it alone. Everyone listening plays a small part in that. We really appreciate the listeners. So, thanks so much everyone and have a phenomenal day.

Evan Brand: Take care.

Dr. Justin Marchegiani: Bye.



SIBO, Yeast Overgrowth, Mood Issues & More – Podcast #169

Your gut affects your health in a variety of ways, and it’s not just about digestion. The health status of your gut can influence the immune system, your weight, and even your mood! In today’s part-podcast and part-Q&A video, let’s join Dr. Justin Marchegiani and Evan Brand as they talk about gut health and how it affects us as a whole.

Watch and listen as they discuss topics like Small Intestinal Bacterial Overgrowth (SIBO), yeast or fungal overgrowth, weight gain and weight loss, and even the link between your gut and your mood swings. So many people are diagnosed with SIBO, in fact, Dr. Justin says that almost 90% of his patients are suffering from this condition. Learn how to manage your gut health by taking the right supplements, eating the right foods, and preventing issues from wreaking havoc on your overall health. Watch this video for more info!

Dr. Justin Marchegiani

In this episode, we cover:

02:30   SIFO is Definitely an Issue

05:20   Conventional Treatment of Candida and SIBO

07:19   Urinary Tract Infection

10:00   Treating UTI by Just Hitting the Gut.

21:36   Top herbs for Candida Overgrowth


Dr. Justin Marchegiani: Dr. J here in the house, with Evan Brand. We’re gonna do a live Q and A call. We may talk about some topics near and dear to us, what’s trending. And then if you guys want to come in on the side and ask any questions, feel free. We are here to serve. Evan, what’s cooking, man?

Evan Brand: Hey. Uh— not too much is cooking but I’m drinking some apple cider vinegar drink. Good old Bragg’s uh— with some cinnamons. So, that’s good. This is a good— like tummy tonic, and there’s a small amount of sugar in here but— Hey, I’ve got Stevia extract in here, some ACV, some little bit of apple juice. I could probably make this myself, but it’s so convenient for two bucks to go buy one of these and just have a nice little tonic.

Dr. Justin Marchegiani: I know. Totally. Just that convenience aspect is really nice. I like the lime one. The lime one’s really good, too. IIt’s only sweetened with Stevia.

Evan Brand: Oh, that one doesn’t have sugar.

Dr. Justin Marchegiani: Yeah. That one’s a good one.

Evan Brand: Oh. Yeah. I didn’t know that…

Dr. Justin Marchegiani: Love it.

Evan Brand: existed.  

Dr. Justin Marchegiani: Wow, man.

Evan Brand: Well, I did an interview uh—

Dr. Justin Marchegiani: Now you know.

Evan Brand: I did an interview this morning uh— with my— for my summit, and it was all about SIFO, so I figured maybe we could chat about that, like Small Intestinal Fungal Overgrowth are what we’re seeing. You know SIBO is such like a hot topic, but people aren’t really talking about SIFO, and you and you and I are seeing so many people every week. I’d say, it’s what— 90 percent of the people have yeast overgrowth?

Dr. Justin Marchegiani: Yeah. I think, when we look at yeast, for instance. You know, we do a typical SIBO test, which looks at Methane and Hydrogen gases, which are— you know— You give a sugar s— solution via lactulose to the per— person, and that sugar’s indigestible to the body, except certain bacteria that are dysbiotic. And when those bacteria eat that lactulose solution, they spit off Methane of Hydrogen gases, depending on wha— what bacteria they are. And that Hydrogen can either disrupt and cause diarrhea or increase motility, or can cause decrease motility via Methane, so— Of course, we see it with various gases indirectly. We don’t know the exact bacteria, but we know that those gases are there because the exhaust created by it. It’s kind of like, you don’t know a car’s in the garage if it’s not there, but if you smell the exhaust that it left a minute ago, you can kind of tell, right? So, it’s kind of like that. And of course, people can have— or patients can have symptoms in their gut via fungal overgrowth. And, symptoms can overlap pretty well, so you may have a fungal overgrowth or something else happening and you may think it’s a small intestinal bacterial growth. You may come back on the test with nothing in that area, but we may do some other testing that shows a fungal overgrowth is present.

Evan Brand: Yeah.

Dr. Justin Marchegiani: So, SIFO’s definitely an issue.

Evan Brand: Yeah. So let’s— let’s go through symptoms a bit. What if somebody know if— or expect that they have SIBO or SIFO? There’s gonna be the bloating, could be fatigue, could be anxiety, could be brain fog, uh— could be food cravings, sugar cravings could be possible. Uh— I mentioned the mood issues, like anxiety, because most people don’t think about it, gut being a cause of anxiety. But it is. And when I had gut issues, I had anxiety. I lost weight. I had brain fog. I had fatigue. It’s all because of my infections.

Dr. Justin Marchegiani: Hundred percent. And a lot of people who have gut issues, right? They’re gonna have a lot of mood issues or energy issues too. It’s very rare that someone only has gut issues. Like, they could have diarrhea, bloating or gas, or indigestion, or GERD, or acid reflux, or gastroparesis with their food, just sits in your tummy for a long time. But it’s very possible that you could just have mood issues, uh— brain fog— With fungus, it’s common to have joint pain. It’s common to have brain fog. It’s even common to have anxiety too. Uhm— the yeast, kind of metabolic products in the gut, uhm— when they metabolize, they can spit off acetaldehyde. Acetaldehyde can then create a compound called salsolinol. Salsolinol can create apoptosis in the midbrain, where it— it can actually kill off some of the uhm— substantia nigra cells that produce dopamine— s, of course, you know, chronic yeast issues, severe yeast issues, but could potentially create more neurological issues due to all the toxic by-products.

Evan Brand: That’s a trip. Now, I know saccharomyces boulardii. We talked about it. We use it for the saccharomyces could do two things, maybe you colla— collaborate on this a bit for the saccharomyces as one, gonna help to crowd out the yeast, but can also kill the toxins that Candida’s producing. Can you speak on that? Do you know what I’m talking about?

Dr. Justin Marchegiani: Yeah. I mean, yeast, Candida can also produce [stutters]— As a by-product, they’re gonna produce mycotoxins, right? And these toxic by-products can disrupt digestion. Uhm— they’re also— you know, acetaldehydes, a stressor that’s produced by the Candida that I mentioned earlier. And Candida’s one type of yeast. You know, they’r— you can have, you know, the Rhodotorula species that— that the cal— Candida albicans, as the Candida of everyone refers to. You have the Geotrichum candidum. You have uhm— these species as well. So, of course these things can cause similar symptoms as SIBO and they can create toxic low because of the how it disrupts toxicity, how it disrupts uhm— digestion. You need nutrients to run our detox pathways. It can create this mycotoxins, which then have to be processed by our detoxification system as well. And of course, it can stress out the immune system because 80 percent of our immune cells live in our gut and it can create more permeability with the gut, i.e., leaky gut, which then gets the immune system fired up. Which is kind of like leaving the uhm— the faucet on in your guest bedroom that you never go into, and your water bill’s sky high that month.

Evan Brand: Yep. Well said. So, let’s talk about treatment a bit. I mean, some of the options that we use, conventional docs. Maybe let’s chat about that first. I mean, we always go straight to the functional medicine piece and assume that people understand that. But I don’t think many people understand what and how poorly conventional medicine treats Candida and bacterial overgrowth type issues.

Dr. Justin Marchegiani: Well, most of the time, conventional medicine’s gonna, you know, typically laugh at your face when you talk about Candida. And unless you have— number one, you have some type of skin-oriented rash, like a tinea versicolor, some kind of seborrheic dermatitis. That’s apparent on the skin, right? It’s like, it’s there. You can see it. It’s apparent they’ll recommend some type of antifungal cream, and they won’t ever look deeper in the gut, which tends to be the root of where it comes from. Or there’s like a vaginal yeast infection or there’s some kind of thrush, where there’s a white coating around your mouth or tongue. So, unless you have those two or three things, for the most part it’s not gonna be picked up. And the Candida like we mentioned can create a whole host of issues: fatigue, mood— It can create things that are none digestive. It can create things that are digestive. I already mentioned. And if you’re going to your conventional medical doctor, it’s typically not gonna be picked up. We can even see it via antibodies, too. So, sometimes people will do a stool test but we’;; actually see the candida via the antibodies. It’s hard to pick up so, we’ll always use clinical symptoms too. Oh, the other one was a fungal tell— fungal toenail.

Evan Brand: Yeah.

Dr. Justin Marchegiani: Like the yellow kind of thickened discolored toenail. That’d be the— the fourth one. [crosstalk] Mouth, nose—

Evan Brand: What about on the fingers, too? I’ve seen people with like a ye— a yellow nail, where it’s like…

Dr. Justin Marchegiani: It’s the same.

Evan Brand: …falling off.

Dr. Justin Marchegiani: It’s the same thing, right? Toenail and fingernail is the same kind of thing.

Evan Brand: Yeah. Okay.

Dr. Justin Marchegiani: Mp— that thickened type of fungal things we see on the nails, on the skin, Uhm— typically, on the mouth, and then typically, vaginal. And let’s say number five would be kind of like a uhm— seborrheic dermatitis, or like a cradle cap, or like a dandruff. It’s kind of in that same fungal category. So, five big ones: hair, mouth, vaginal, skin, nails…

Evan Brand: Got it.

Dr. Justin Marchegiani: …toe or finger.

Evan Brand: Yeah. So, let’s talk about UTIs for a bit. Now, when you hear about a Urinary Tract Infection, a lot of times, this is affecting women. Is that bacteria plus Candida [crosstalk] at the same time?

Dr. Justin Marchegiani: Typically— It depends. Typically, it’s gonna be bacteria. The— the number one way you can figure it out is typically bacterial vaginosis. We’ll have kind of a fishy odor to it. So, it’s gonna a little bit fishy, in women. No, it’s like— okay, it’s apparent something’s going on down there. Yeast infection, typically is not gonna smell like that. It may smell a little bit yeasty, almost like a buri kind of smell, but it’s not gonna have that kind of fishy odor smell. That’s the number one. Both are gonna have discharge. [crosstalk] Both are gonna have discharge, typically like you know, kind of a cottage cheesy kind of fim. Uhm— you know— We’re getting pretty graphic here but hey, this is— this is what we do, all week long. So, of course, that’s the big way. And then, typically, the UTIs can affect primarily the urinary tract, right? Bacterial vaginosis involves more the Gardnerella bacteria. Uh— the UTI is more gonna be the E. coli bacteria. And then, of course, yeast is gonna be more like your Candida albicans kind of thing. So, of course, like if it’s a UTI, you know, you tend to feel it. It tends to hurt more when you pee. A little bit of pain or stinginess when you pee; bacterial vaginosis, probably not as much. Maybe just itchy. And the big— you know, dividing factor would probably be the odor, as how you would know.

Evan Brand: Okay. And then [inaudible]—

Dr. Justin Marchegiani: Of course, you can get a culture. You can get a culture, right? You go see your doctor. They may do a culture, but in terms of treatment for bacterial vaginosis, we may do kind of an herbal formula, mixed with apple cider vinegar. And we make it like a douche applicator and flush that area out for a week or two. And then, we may throw some probiotics in, internally via the mouth and intervaginally to help shift the pH. Typically, getting more acidic pH makes it harder for that bacteria to grow. Obviously cutting out the refined sugar and the junk of your food, too. With yeast, similar thing. We have some Boric acid or suppositories that we’ll use. The help will also get the probiotics going. Cut out the refined sugar. And then for UTI stuff, we’ll typically use some Silver. We can use some D-Mannose powder. We can use Uva Ursi herbs. Uhm— we can do apple cider vinegar, lemon juice. These are all really good things that we can do to help acidify the p— acidify the urinary tract. Also we can do cranberry juice extract, unsweetened organic. We can also do some organic cranberry pills as well. That has a big shift on the pH in the urinary tract, which then starts to starve them out because they— they tend to not live as well in that nice acidic environment. They tend to grow more in an alkaline environment.

Evan Brand: So, let me ask you this. Could you successfully treat a UTI just by hitting the gut?

Dr. Justin Marchegiani: Uhm— you could. Uhm— again, like some of the things we’d want to do is to want to make sure we have some of those herbal metabolites make their way out the vaginal, you know. I mean, typically UTI it’s gonna go out, right? It’s gonna head some and go out, and so the urinary tract will be hit. The question is, “Will the vaginal area be hit.”  Obviously, for peeing it out, it’s not gonna be hit. It’s close in that area, but more than likely it’s not gonna hit it. That’s where you need some kind of an herbal douche formula to topically get in there. Same thing with the yeast. So, yeast, you kind of want to top like in there with a suppository. BV get in there uhm— with a— a flushing type of herbal mechanism, and just make sure you’re not pregnant, right? ‘Cause the— there could be some abortifactant uhm— mechanism there if it’s getting too close— you know, up the vaginal canal. And then, uhm— number three is the UTI that we could do internally, and we could flush out that way.

Evan Brand: So, could you go— I mean are there like professional grade herbal douche blends, or is that something you’ve got to piece together yourselves? Like, does the store-bought version exist?

Dr. Justin Marchegiani: Yeah. I have one that I use that works really well. It’s good to call herbal douche formula, and that we should choose an applicator when we mix— mix it with some apple cider vinegar, like the instruction’s say, and we flush one— one or two times a day. [crosstalk] I’ve got to shift the diet. I’ve got to shift the diet. Typically, it should do a— a really good probiotic intervaginally, as well, that kind of help shift the pH and shift the microbiome there.

Evan Brand: Is there a brand for that?

Dr. Justin Marchegiani: Yeah. I like one by Wise Woman Herbals.

Evan Brand: Okay.

Dr. Justin Marchegiani: [inaudible] … for the herbal douche formula, and then the probiotics will typically do, you know, my Probio Flora or will do a Woman’s formula. But typically, the Probio Flora is enough as well.

Evan Brand: Cool. Okay.

Dr. Justin Marchegiani: Probio Flora too is uhm— the Phage in there really helps kill uh— E.coli too. So, if it’s any UTI stuff going on too, that could also help with that too.

Evan Brand: I’m gonna bookmark that. That’s really really cool. And this— I feel like the douche is something good where if you’ve got like a resistant infection or something that just keeps coming back. Sounds like that would be a good thing to add in.

Dr. Justin Marchegiani: Yeah. And then, typically though, even if we ever— let’s say, we do topically hit that area, we still want to make sure we systemically treat things too. Like, we would topically hit something ‘cause you want a faster results.

Evan Brand: Right.

Dr. Justin Marchegiani: Like, let’s say, there was a fungal nail, right? And maybe really hard to get rid of that fungus on that nail if we just hit it to the gut. So, we kind of want to hit it from both ends. So, we kind of want to put that critter between a rock and a hard place. Make it so it has nowhere to go.

Evan Brand: So, do you add apple cider vinegar, too. That’s— I know it comes [crosstalk] west.

Dr. Justin Marchegiani: Yeah. We’d add it to it.

Evan Brand: Okay.

Dr. Justin Marchegiani: Make it says like add six ounces of apple cider vinegar or something. If you read the jo— instructions on how to mix it.

Evan Brand: ‘Cause like in ingredients, it says it’s in a base of ACV. So, I was just curious.

Dr. Justin Marchegiani: Can you read the in— Can you read the instructions?

Evan Brand: Yeah. It says, “Add one tablespoon of concentrate per six ounces of warm water.”

Dr. Justin Marchegiani:Per warm water?

Evan Brand: Yeah.

Dr. Justin Marchegiani: Got it. Yeah. So then it’s the warm water then. So, the apple cider vinegar’s already in it. SO, we will just add that to the warm water.

Evan Brand: That’s really cool, man. I learned something new everyday.

Dr. Justin Marchegiani: That’s it.

Evan Brand: Wow. Well, thanks. [crosstalk] Let’s look at some questions and see what we’ve got here, digestively. Uh— Evie ask you a question, “Dr. J, I’ve been taking your Digestive Supreme and HCL. They’re helping a lot. Thanks. Is it okay to take for a long time or should I stop after some time?

Dr. Justin Marchegiani: So, typically, if there was an infection, we want to get rid of the infection and then we can taper it down. And then, the rest is gonna be based upon you. So, if you’re under a lot of stress during the day, you know, then we may want to take it during stressful period. If you’re eating food that’s maybe a little bit questionable, we want to save it for that. So, get rid of the infections. Get rid of the internal stress that’s causing the issue. You know, as long as your diet’s on track and the stressful environment is kind of under control or you’re not hydrating so much during the meal, then I think it’d be okay to reduce the consistency on that, for sure.

Evan Brand: And I— I— I’ll throw my two cents in.

Dr. Justin Marchegiani: Yes.

Evan Brand: I cycle on and off enzymes, personally.So, I just got my Stool testback. I showed up with some gut bacteria, showed up with the cyclospora parasite. So, needless to say, I’m back on enzyme ‘cause I’m clearing out these infections because the last thing you want is undigested food particles feeding the bugs. Like Justin mentioned, if you’ve got an infection, something that— like H.pylori could be suppressing stomach acid. You know, that’s undigested food that’s going straight to the bad guys. So…

Dr. Justin Marchegiani: Yeah. And I noticed myself. I was just having a— like uh— looser stools for the last few weeks only after coffee, and it was just— typically, was a different consistency. So, I just start on. I used to hit my GI Clear 4 and Para 1 up, and I noticed that it did start to solidify again even after coffee. So, I’m gonna be doing the GI Map Test at the end of this month…

Evan Brand: Good.

Dr. Justin Marchegiani: …and see what at.

Evan Brand: Well let’s go through your results when they come.

Dr. Justin Marchegiani: Yeah.

Evan Brand: It’d be a fun show.

Dr. Justin Marchegiani: Yeah. I’m excited. Then also uhm— I saw your test last night. I saw the increased steatocrit on yours…

Evan Brand: I know.

Dr. Justin Marchegiani: …and the increased beta-glucuronidase. So, definitely hitting it with the antimicrobial herbal stuff, maybe adding in some extra bile salts or lipase in there too would also help.

Evan Brand: Yeah. I appreciate it. I’m gonna uh— I’m gonna do that, and then also, I’m gonna add in some milk thistle too. Try to get that glucuronidase down.

Dr. Justin Marchegiani: Yep.

Evan Brand: No probiotics can do it, but I think I rather probably do both.

Dr. Justin Marchegiani: Well, yeah. I mean, glucuronidase is gonna be— if you kill the bacteria, that— that will go down, too.  

Evan Brand: Okay. That’s cool.

Dr. Justin Marchegiani: You can just throw in some extra charcoal to help bind that up too.

Evan Brand: Okay. Also, uhm— we’ll have to chat but uhm— where we’re getting our Para 1. There’s also a binder that they’ve got, which is like a Fulvic acid – Charcoal mix.

Dr. Justin Marchegiani: Yeah. I’ve seen that . I think that’s good too. Uhm— I find that— you know, the charcoal’s still really good as well. So, you could do either one [crosstalk] then. I like the charcoal.

Evan Brand: Yeah. And the charcoal’s so cheap.

Dr. Justin Marchegiani: That’s the thing. The charcoal’s just a little bit more cost-effective, that’s why I like it.

Evan Brand: Yeah. You can’t beat it. Okay, [crosstalk] cool.

Dr. Justin Marchegiani: And it’s still great. I mean, it’s still— you know, you can use it for alcohol— I had— my Patriot’s play yesterday, my Tom Brady. They’re just freaking awesome, man. He used to go— and— you know, he is just like the perfect— like practitioner spokesperson for natural medicine. I mean, what he does, what his diet, and he eats basically a Paleo Autoimmune Template for the most part. He’s trying to keep inflammation down.

Evan Brand: Yep.

Dr. Justin Marchegiani: And uh— you know, he trains in a way that to support pliability and muscle length, and then which we’ll have to uhm— try to get his trainer on, man. I got to get him on…

Evan Brand: Good.

Dr. Justin Marchegiani: …and speak to him. I know. We’re gonna work on that. But yeah, he’s a perfect practitioner of all these stuff. But uhm— in regards to—- where was I going? So, we just talked about?

Evan Brand: I think you were talking about—

Dr. Justin Marchegiani: Oh, yes! I’m sorry. So, I had a nice glass or two of champagne yesterday.

Evan Brand: Oh.

Dr. Justin Marchegiani: So, I hit up some activated charcoal, and I hit up some Sulfur amino acids, and I feel phenomenal. No issues. Then, of course, I have a nice glass of mineral water in between drinks that prevents any— you know uhm— the antidiuretic hormone that’s being reduced. So, all the peeing that happen from alcohol, prevents any of those minerals from being washed out. So, that’s my little tip there.

Evan Brand: That’s cool. Uh— anybody uh— listening, watching, add your comments. We’re gonna go through these. We’ll try to answer as many that are on topic as we can. So, add your comments now. So, we’ll go through it now.

Dr. Justin Marchegiani: Yes. And we’ll hit the ones that are on topic— is— is first. And then also, give us a share, give us a like, give us a thumbs up. We appreciate it, guys. Help us grow so we can help more people like you. Your benefitting right now. Don’t keep it all to you. Let it get out there. We appreciate it.

Evan Brand: Absolutely. Uh— what’s our time on? How much time we got left with these questions?

Dr. Justin Marchegiani: We— we got five minutes. Let’s roll for it.

Evan Brand: Okay. Alright. So, we’ve got one here from Jeff. Uh— he says that he’s been taking the GI Clear 1, 2 and 5. Two caps a week for H. pylori. Yesterday was his birthday. He’s been so sick; nausea, headaches, panic attacks. How should I take the herbs on an empty tummy?

Dr. Justin Marchegiani: So, number one, I‘m imagining that because it was your birthday, you may have gone off the—

Evan Brand: Oh, oh.

Dr. Justin Marchegiani: …of the rings there, Jeff, maybe with some extra birthday type of uh— surprises or things like that. So, there could be that. Uh— number one, if we’re having some sensitivities, we need to come off the herb for three to five days, get back to base line, add them a ginger tea, and then ratchet up one capsule per day on each herbal product. If you hit the wall, meaning you start to have those nausea or negative symptoms, you  back off. Get super stable before you go to the next. And of course, if you’re having issues, take it with food, because the food kind of prevents a buffer. So, those herbs aren’t sitting up against an irritated gastric mucosa, add in the ginger and then we should probably throw in some activated charcoal in between breakfast and lunch away from food and lunch and dinner away from food. That will maximize absorption of any of the— the toxins. But dial in the dose. Don’t be a hero and push it too high and too fast. Take it with food. Take a couple of days off. And then, add it back in.

Evan Brand: Yep. Good advice. Now, the question here. Dr. J, I’ve been following your advice but not perfectly. I’ve had long term constipation, GERD, gastritis, H. pylori, bloating, abdominal distention, cramping. How can I help myself? I’ll answer this one.

Dr. Justin Marchegiani: Yes.

Evan Brand: If you don’t mind.

Dr. Justin Marchegiani: You got it. Do it.

Evan Brand: Uh— You’ve got to get tested. I know you said, “I’ve been following…

Dr. Justin Marchegiani: Uhmmn—

Evan Brand: “… meaning you’ve probably been watching Dr. J’s videos, maybe some of the stuff that we’re doing together like this. But if you’ve knocked out the testing done, then you’ve— you’ve got uh— you’ve got to do that. If you say H. pylori— if it’s still there, you’re gonna have these symptoms. So, you’ve got to get some functional medicine testing. You can reach out. Get that done. And, we’ve got to fix the bugs. You’re never gonna fix constipation if you’ve got bacterial overgrowth ‘cause those gases are gonna change the intestinal motility time. Bloating; same thing. That could be yeast, fungus, bacteria, H. pylori. We know that’s why you’ve got the GERD, because that’s suppressing your stomach acid. You’re gonna have heartburn because your body’s not gonna allow the undigested food to go down. So, get tested and then we can use herbs to fix this.  

Dr. Justin Marchegiani: One hundred percent!

Evan Brand: Uh— let’s keep going here. We’ve got another [crosstalk] question from Kitty. Uh— She’s taking the beef protein powder. That makes her constipated so she take HCL and pepsin even though it’s a powder.

Dr. Justin Marchegiani: I would say, you could try it, and see what happens. If it doesn’t work, there could be something in it that you’re allergic to so I would try a Collagen protein that’s in a peptide form and see if that shifts or changes it. ‘Cause that’s gonna be in a more broken down assimilated form. [crosstalk] So, try it. Try more enzymes and HCL, and see what happens first. And then try just a really clean— like— you know, my TRUCOLLAGEN. Try something in a collagen peptide form…

Evan Brand: Yeah.

Dr. Justin Marchegiani: …and see if that fixes it. And then, let us know.

Evan Brand: Good advice. Another question, “Hi, Dr. J. I’d like to ask you uh— how to detox from heavy metals toxins, parasites, etc., naturally?” We’ve done a ton of shows on this. We’ll continue to probably hit this topic, but just searched or search the YouTube channel here for those ti— uh— those titles, and you’re gonna find some stuff. But that— that could be an hours and hours and hours conversation.

Dr. Justin Marchegiani: Totally. Yep. Absolutely.

Evan Brand: Samuel. Want to read that one?

Dr. Justin Marchegiani: Yeah. “Is it possible to overpopulate with good bacteria using probiotics? And if so, what steps do you take to balance?” So, number one, we can see it with patients that tend to have like digestive issues or SIBO. We see an excessive amount of D-lactate, which can be caused by throwing a whole bunch of Lactobacillus in with the whole bunch of dysbiotic bacteria. So, we can see that. So, number one, make sure we’re starting from a blank canvas, not a canvass full of messiness from the start. Uhm— number two, probiotics tend to be transient. They’re not gonna stay around longer than a month or so. So, they are transient. So— Number one, a good steady dose of them is gonna be fine. So, you know, two to four capsules I think is a reasonable amount, like with my Probio Flora. And I think, you know, some couple sources of fermented foods that you want to throw in a weekly, whether it’s a lower sugar Kombucha, fermented pickles, sauerkrauts, uhm— those are all good standard options that you can kind of add in. And, I think, as long as your digestive symptoms are under control and you’re infection-free, I would not worry about it. If you’re having a lot of blow or gas because of probiotics, you probably have to look a little deeper and see what’s happening with the dysbiosis or other infections.

Evan Brand: Yep. One more questions right next to that. You want to hit that one too?

Dr. Justin Marchegiani: Top herbs for Candida overgrowth?

Evan Brand: Yep.

Dr. Justin Marchegiani: Oil Oregano, Berberines, Silver, not really an herb but it’s still something that we use, uh— Clove, Wild Indigo, grapefruit seed extract; I would say those are a couple, right there. Anything you want to add?

Evan Brand: Yeah. I’d like to add olive—

Dr. Justin Marchegiani: Anything like a medicine?

Evan Brand: Yeah. Olive leaf.

Dr. Justin Marchegiani: Olive leaf, yep.

Evan Brand: Uhm— the monolaurin, the lauric acid…

Dr. Justin Marchegiani: Monolaurin, lauric acid, yep.

Evan Brand: Uh— I would also say— I mean, we’ve got so many formulas. I would just say to look at our— look at our GI formulas. Justin’s got several custom formulas I do as well. You could check our sites,, We’ve got many. And these herbs in isolation can work— can work pretty good, but we’ve really like to focus on the synergistic effective herbs together.

Dr. Justin Marchegiani: Yeah. like, for instance, Berberines, and Artemisia. If you look at Stephen Buhner’s book, he talks about the synergistic effect that you have with those herbs together. So, like one and one equals ten, not two. So, combining some of these herbs, they have to work phenomenal.

Evan Brand: Yeah, uh— you want to hit Tammy’s question?

Dr. Justin Marchegiani: Yeah. “I got stomach pain when I take Proteolytic enzymes. What does that mean? I had H. pylori and stomach ulcers twice in the past. So, number one, I’d make sure you’re not taking the enzymes on an empty stomach. I’ll take them in the middle of the meal. Okay? Number two, I would just see that, you know, if you didn’t take the enzymes, would you also have stomach pain? Or is it— Is the enzymes the only variable factor? And if you have a lot of stomach ulcers and those kind of things, number one, we need a support and start adding some healing and soothing herbs. Potentially, lower the dose and make the food more liquid or predigested in kind of like a crock pot type of format. So, the food is easier to process. Nothing raw. Even if it’s like, raw broccoli or like raw Paleo veggies, that may still be too much. So, I would look at crock pot liquid form, healing-soothing herbs and amino acids. Kind of what’s in my GI Restore. Uhm— add every variable in one at a time so that way you know. You get the foods dialed in, right? You get, you know, the type of food and the cooking process dialed in. You add some soothing herbs. You do the enzymes. You start with the very low dose. You work it up. You isolate. You do one of each variable, one at a time. So, you know what’s going on.

Evan Brand: Yep. And I would like to add. Make sure that you’re infection-free. You said you had H. pylori and stomach ulcers twice in the past. Uh— gastroenterology is very very very uh— inaccurate. Some of their testing. You can have false…

Dr. Justin Marchegiani: Yeah.

Evan Brand: …negative [crosstalk] in every week though. Just get retested. Make sure you’re free and clear. Make sure there’s no other infections or that H. pylori plus vitamins factors, which is something we test for. Make sure that that’s not there.

Dr. Justin Marchegiani: And again, here’s the deal, too. If you’re having issues potentially with food or enzymes, then you sure as heck gonna have issues with herbs to knock out the infection. So, work on the first three R’s first: removing the bad foods, replacing enzymes and acids to the right dosage, taken the right way, healing-soothing nutrients and adrenal support. So, adrenals, ginger tea, amino acids, healing-soothing herbs, and then, make the food really palatable so it’s easy to process.

Evan Brand: Uh— Great. Great advice. Angel, “Do you recommend diet to Diatomaceous Earth for Candida?

Dr. Justin Marchegiani: I think it’s great to help uhm— with the killing and binding effect that’s good at worms. Uh— I use it to kill ants in my backyard when I see them. Uh— Diatomaceous Earth has a high amount of Silica in it and it basically dehydrates the uhm— the exoskeleton of the— the insects. So, it’s a great non-toxic thing. You can also swallow it too so it can— it can dehydrate the worms, too, and kill them.

Evan Brand: That’s neat. Now, question from Narine, “You two are awesome.” Thank you, Narine. Where do you guys practice? So Justin, uh—

Dr. Justin Marchegiani: Everywhere, in the ether.

Evan Brand: Yeah, everywhere. Justin lives in Texas. I live in Kentucky. But, we are 100 percent via phone and Skype consults. That’s it. Uh— Riley, “ How long should you take the GI Restore 4 with probiotics after a parasite killing protocol?

Dr. Justin Marchegiani: Uh— typically, combination— typically, if we’re looking at it objectively ‘til calprotectin goes down, which is an inflammatory uh— protein that’s produced by the gut when there’s inflammation, and/or ‘til you’re infection-free. So, for infection-free, then we really want to see that calprotectin go down, and ideally, that correlates with symptoms and improving in the gut mucosa just becoming better and feeling better.

Evan Brand: I would say, generally, though, the given number— I tried to get people to run…

Dr. Justin Marchegiani: Two  to four months.

Evan Brand: …[inaudible] models.

Dr. Justin Marchegiani: Yep. I think two to four months on average. I know Riley’s case in particular. You know, he’s had issues with H. pylori in the past. So, there could be just some— some thinning gastric mucosa, that’s just more sensitive, and we just need to make sure that infections crossed off our list. And then start the timer, you know, two to four months from when that infection is gone.

Evan Brand: Okay.

Dr. Justin Marchegiani: Kind of thing—

Evan Brand: That’s good. That’s good. Uh— Addy asks, “ Do we  recommend Grapeseed extract for Candida?” Yes. We use it [crosstalk] in our formulas. It can help.

Dr. Justin Marchegiani: Absolutely.

Evan Brand: Uhm— uh— another question here. “Thoughts on prebiotics supplements?” I think it’s our last question uh— that we have time for. “Do we need prebiotics if we have lots of vegetables in the diet?”

Dr. Justin Marchegiani: I think you can throw in some resistant starch either some unripened banana flour or a little bit of a cool potato flour. I think that’s great. Throw in a protein shake. Uhm— we typi— and I think my Probio Flora, and maybe your probiotic, there’s a little bit of Inulin or Chicory root, which can be helpful. Uhm— but in general, some of that starchy carbohydrate, and it can start with the very small amount, can be helpful. And take a look at my videos on resistant starch for more info on that.

Evan Brand: Oh, good. Good. Good. Good. Glad you got a video there. Well, that’s all we got time for, question-wise. I think we hit most of them, though. Unless there were some off-topic. But, we hope this was helpful. Make sure you guys hit Subscribe if you’re not subscribed to the channel. Go ahead. Hit subscribe right now, because you’ll get notified. Make sure you hit the bell too, ‘cause we—

Dr. Justin Marchegiani: Hit the bell!

Evan Brand: …we’re back [inaudible]…

Dr. Justin Marchegiani: Everyone’s like, “Hey, Dr. J, like when are you gonna be live?” So, we’re gonna try to let you know a day ahead of time. But if you hit the bell, It’s gonna pop-up on your YouTube app, on your computer or phone. It’s gonna say, “Dr. J and Evan are live.” And then, you’re gonna know.

Evan Brand: Generally speaking though, you guys should expect us here every Monday at anywhere between 11:30 and 12:00 Eastern.

Dr. Justin Marchegiani: Yeah. That’s the general kind of gist and I’ll be online typically 9:30 to 10:00 CST, which is 10:30 to 11:00 EST on Fridays, for our FAQ for you all.

Evan Brand: So, s— you know, go ahead and stalk us here. Subscribe, hit the bell and we’ll be back for more content very soon. If you have…

Dr. Justin Marchegiani: Oh, one last question here.

Evan Brand: Yeah.

Dr. Justin Marchegiani: One last question. “Can you overdo with herbs?” Yeah, you can, Charlotte. So, just make sure if you’re— people thata are sensitive, they kind of already know it, right?

Evan Brand: Yeah.

Dr. Justin Marchegiani: They have issues with Vitamin C and issue with probiotics or issues with HCL, and it’s like— these are patients like we got to take our kid gloves and put them on ‘cause we got to go. Everything has to be very slow and very gentle. And it’s not that you’re— you’re weak or have— you know— It’s not anything— It’s not a negative on you. It’s just your system, where it’s at. So, if we go a little bit slower, it helps. It’s kind of like, you want to take a cold shower, get in the shower. Get it on warm and then just inch the dial a little bit co— you know, to the cold direction. And then, before you know it, in three to five minutes, you’re in a cold shower. And it wasn’t that difficult. So, if we have to, we can go slow. Of course, working on ginger tea and soothing nutrients to get the gut lining more tonifying, relaxing things, adrenal support. And then we can inch into the herbs as well. So, for sure. Absolutely.

Evan Brand: Oh, I’m gonna advise, two cents…

Dr. Justin Marchegiani: Yes.

Evan Brand: …because you made some word adrenal. Yeah. If your adrenals are weak, you gut protocol is going to be much more uh— heavy hitting on you. So, if— if you’re working on with a practitioner and you guys are just looking at the gut, make sure you’re asking questions about thyroid and adrenals and hormones. Because, you know, Justin and I are utilizing a Three Body System Approach, which is adrenals, gut, thyroid detoxification. Things like that.And if all these other pillars aren’t there, and you’re just hitting one avenue really hard, you’re gonna crash out. So, make sure those other— other pillars are involved. Otherwise, the progress will not be as well. And I could explain why you’re not handling the herbs as much.

Dr. Justin Marchegiani: And it’s human nature. Once people find out they have a critter in them, they’re like, “Get rid of it! Oh, my gosh! This is awful.” And I— I get it. So, normal reaction, but we have to make sure the bigger picture is we don’t to get reinfected. The bigger picture is we don’t want to feel worse either. So, there’s this a sequence in which we have to do. And it takes a little bit of trust because the normal reaction is, “Get rid of it now.” “Get rid of it yesterday,” right?

Evan Brand: Yeah. For sure.

Dr. Justin Marchegiani: Okay. Awesome. Well, great call. Slam that bell. Give us a share. We appreciate everyone watching. And hope everyone’s health takes one notch in the right direction today. [crosstalk] Appreciate it all.

Evan Brand: Take care.

Dr. Justin Marchegiani: Bye, Evan.

Evan Brand: Bye.


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Curing Candida Naturally

Curing Candida Naturally

By Dr. Justin Marchegiani

While research shows that Candida affects approximately 70% of the population, few people know what Candida is, and even fewer know it when they’re infected. Candida overgrowth is the most common type of fungal yeast infection. Like most fungi, Candida is a fungus that can live harmlessly within your body. In fact, proper levels of Candida can even be beneficial to our digestion! However, when Candida overgrowth occurs, problems begin to arise. Today we’re going to discover the signs and symptoms of a Candida overgrowth, and learn ways to treat this infection naturally.

Causes of Candida Overgrowth

Causes of Candida Overgrowth

Candida overgrowth has become increasingly common due to our changing lifestyle and dietary choices. Below is a list of some of the most common causes:

  • A diet high in sugar, processed carbs, and alcohol: Yeast lives off of sugar, whether it be refined sugar or the sugar from fruit and carbohydrates. Sugar and alcohol both deplete healthy gut bacteria, which creates just the environment that yeast needs to thrive.
  • Taking antibiotics: Antibiotics are literally meant to kill bacteria. The problem is that they don’t discriminate, and end up killing off the good guys, too.
  • Using birth control: Women taking birth control pills have been shown to be twice as likely to develop vaginal yeast infections like Candida.
  • Weakened immune system: Those who suffer from or who have undergone cancer or HIV/AIDS treatment have lowered immunity and are more susceptible to infection. Infants, the elderly, and those suffering from autoimmune diseases are also more likely to develop fungal overgrowth.

Identifying a Candida Infection

Identifying a Candida Infection

Candida overgrowth is hard to detect. A person can look perfectly healthy on the outside, but be silently suffering on the inside. If you self-identify with any of the causes of a Candida infection, check out this list of common symptoms to further determine whether you suspect this overgrowth may be harming your health:

  • Lack of energy; easily exhausted
  • Craving sugar, sweets, and carbs
  • Bad breath; white coated tongue
  • Brain fog, tiredness, confusion, memory problems
  • Joint pain, muscle aches, swollen joins
  • Lowered libido or complete loss of sex drive
  • Chronic allergies; frequently sick
  • Digestive troubles: bloating, gas, excessive burping, constipation, diarrhea
  • Infertility
  • Mood swings; anxiety; depression
  • Insomnia
  • Bloating, belching, intestinal gas, and/or abdominal pain
  • Burning or itchy vagina, unusual discharge, frequent vaginal infections

Because the list of symptoms is vast, it is hard to diagnose Candida overgrowth and it often goes undiagnosed or misdiagnosed. If you suspect you have a Candida infection, it is a good idea to follow the diet and wellness recommendations to fix Candida overgrowth. This is a case of “better safe than sorry,” because even if you aren’t infected, these guidelines are still beneficial to your health! If you’re someone who loves to self-quantify or is just curious, a functional medicine doctor is trained in identifying this issue, and can even help you with a stool test to know for sure if you have a Candida overgrowth problem.

Click here to work with a functional medicine doctor to balance your Candida levels!

Natural Remedies for Candida Infections

Natural Remedies for Candida Infections

Perhaps the most effective treatment for Candida overgrowth is a dietary makeover. The recommendations outlined below will build your immune system and eliminate foods that feed the fungus.

  • Garlic contains sulfur which is particularly skilled at killing fungi. Be sure to use raw garlic to reap all the benefits of its antifungal properties!
  • Eat your greens! Leafy green vegetables contain a host of vitamins and minerals which boost your immune system. While yeast is acidic, green vegetables are alkaline, which makes them great at fighting off Candida.
  • Limit fermented foods: “But fermented foods are good for me!” While this is true, overdoing fermented foods can actually feed Candida! While the good guys need fermented foods to thrive, the bad bacteria (such as Candida) like them too. For the duration of the Candida cleanse, limit fermented foods.
  • High-quality probiotics will help restore balance to your gut bacteria.
  • Coconut oil is more than a delicious and healthy fat, it is also antimicrobial! Caprylic acid, a main component of coconut oil, actually kills Candida. If you don’t use much coconut oil, taking caprylic acid as a supplement will help get the job done!
  • Swap sugar for stevia. Sugar feeds yeast, while stevia actually kills it!
  • Oregano and clove oil kill off parasites and fungi such as Candida.
  • Limit your exposure to environmental toxins. This may mean it’s time to look at natural beauty products and cleaning products. Be cautious of perfumes, paints, and other strong chemicals.
  • Vitamin C boosts your immune system, supports your adrenals, and helps your stomach acid fight Candida.

Keep in mind, you may experience bloating, headaches, and breakouts while you’re body detoxes. This is to be expected, because while your body kills off the fungus, dozens of toxins are being released! In 1-2 weeks, you will begin to feel much better as the Candida will effectively be removed from your system. For maintenance, you can resume normal consumption of fermented foods, and should maintain a diet low in sugar, alcohol, and processed carbs.

Click here for a holistic health consultation and start feeling better today!

Hashimoto’s Disease and The Infection Connection

hashimoto's disease

By Dr. Justin Marchegiani

Hashimoto’s Disease, is an autoimmune disease, a disorder in which the immune system turns against the body’s own tissues. In people with Hashimoto’s, the immune system attacks the thyroid. This can lead to hypothyroidism, a condition in which the thyroid does not make enough hormones for the body’s needs.

While a healthy immune system resists infection, a weakened immune system welcomes it in with open arms. Infections thrive in unhealthy environments. And once a bug (parasite, bacteria, fungus, or virus) moves in, it can be difficult to exterminate.

Infections can worsen autoimmune conditions of the thyroid (such as Hashimoto’s thyroiditis and Grave’s disease) and other parts of the body. It can also create inflammation, disrupt detoxification, and wreak havoc on the digestive system. So the bug has moved in—here’s what you need to know to minimize infection and protect your thyroid.

Bacteria in the Gut: The Good vs. the Bad

Our gut needs good bacteria to function and thrive. A ratio of 80% good bacteria and 20% bad is a healthy level of gut bacteria.

An imbalance in this bacteria (e.g., 80% bad and 20% good) is called dysbiosis. Overgrowths of yeast (such as Candida) or infections (such as H. pylori) can cause this imbalance.




Good bacteria consume toxins and send nutrients to the body. Bad bacteria consume nutrients and send toxins to the body. Those bad bacteria can lead to a leaky gut.

Small intestinal bacterial overgrowth (SIBO) is a condition that’s driven by bacteria that’s migrated from the large intestine into the small intestine. They’re in the wrong place. This can produce toxins in the gut and disrupt peristalsis (the wavelike contractions that move stool through our intestines).

If we have a delay in peristalsis, we can reabsorb a lot of the toxicity. This is called autointoxication.

Infections in the gut can be particularly challenging and difficult when they accompany an autoimmune condition.

If you are concerned that you might have a gut infection, please feel free to reach out here for help!

Infection with an Autoimmune Condition (Hashimoto’s)

When we have an autoimmune condition, this simply means the body is making antibodies that can’t tell the difference between the invader and the body itself. Antibodies are proteins that fight invaders such as bacteria and viruses. So while the antibody may fight the invader, it will also attack a specific part of the body.

In the autoimmune condition Hashimoto’s thyroiditis, the body makes antibodies to thyroid peroxidase (TPO) causing thyroid breakdown. In Grave’s disease, the body makes antibodies to thyroxine-binding globulin (TBG) causing thyroid breakdown.

Infection Leads to Leaky Gut Leads to Thyroid Breakdown (Hashimoto’s)

The bad bacteria (overgrowths of infection) in the gut pave the way to a leaky gut.

When our gut becomes leaky, undigested food particles pass through “leaks” in the gut and enter the bloodstream. The surface proteins on gluten, for example, can look very similar to the thyroid and cases of “mistaken identity”. This is known as molecular mimicry. This is true for other body tissues as well. Dairy can look like the pancreas, for example.

So the immune system starts making antibodies for the thyroid because it can’t tell the difference. And then know, the thyroid is under attack.

Infection and a leaky gut are two of the prime mechanisms that exacerbate the breakdown of the thyroid.


immune system


Infections That Impact the Gut and Thyroid

A few common infections that are found when dealing with leaky gut and thyroid issues follow:

  • Helicobacter pylori (H.pylori)—This bacteria is common in greater than 50% of the population. It can drive autoimmunity in Hashimoto’s. Also, it is linked to other autoimmune conditions. It is transmitted through saliva or fecal contamination.
  • Borrelia burgdorferi (Lyme disease)—This bacteria looks similar to the thyroid, so it can exacerbate autoimmunity. It can be acute or chronic and is transmitted by the deer tick.
  • Yersinia enterocolitica—This parasitic infection can trigger thyroid conditions and autoimmunity. It is transmitted through contaminated food and water.
  • Candida—This fungal infection disrupts digestion, throws off good-bad gut bacteria balance, and creates constipation. It is transmitted through direct contact and can be spread by contact with contaminated objects.
  • Epstein-Barr virus (mono, the kissing disease)—This virus causes an imbalance in the immune system and is present in 80–90% of the population. It’s connected to many autoimmune conditions, including Hashimoto’s. It is transmitted through saliva.

Removing the Infection Isn’t the First Step

Addressing infections can be stressful on the body. Being unhealthy means having an imbalance in gut bacteria, poor gut function, adrenal issues, energy issues, a bad diet, poor sleep habits, etc. When we are unhealthy and we knock out an infection, our body has to deal with the dead debris.

The infections are like soldiers fighting on a battlefield. We introduce our natural or herbal antibiotics to destroy the infections. Massive numbers of soldiers (the infections) are falling all over the battlefield.

Our immune and detoxification systems have to send out the medics to help pull the soldiers off the battlefield, but there are just too many soldiers (too much infection debris). The medics (our immune and detox systems) get backed up. And there’s a huge line of soldiers that still need help.

Once our immune and detox systems are backed up, this creates a Herxheimer reaction. In this reaction, the harmful biotoxins from the infectious debris accumulate. Then, they start creating stress on our immune, detoxification, and lymphatic systems. The medics are stressed—they can’t keep up.

To eliminate the stress of infection debris on the body, removing infection should be the fourth step in a five-step (the 5Rs) strategy that can be found in detail at this link, and briefly below:

  1. Remove hyperallergenic foods.
  2. Replace enzymes, acids, and bile salts.
  3. Repair with healing nutrients and adrenal support.
  4. Remove infections
  5. Reinoculate with probiotics.

Removing infections can leave the gut empty. It will even knock out some good stuff, too. And weeds (bad bacteria) tend to grow automatically in this world. Gardeners don’t go to Home Depot to pick out weeds to plant. Weeds just happen. So it’s important to reseed the gut with the good bacteria after removing infections.


Studies have shown that when certain infections are removed, we see a significant decrease in the amount of thyroid antibodies. This means that these infections are driving the immune system to destroy the thyroid faster. So if we can knock out the infections, ideally naturally, herbally, and safely, we can reduce the self-destruction of our thyroid tissue. That’s the goal.

Determining if you have a thyroid and infection connection can be difficult. Please don’t self-diagnose, but feel free to click here for help.


Featured image from

Benvenga S, Guarneri F, Vaccaro M, et al. Homologies between proteins of Borrelia burgdorferi and thyroid autoantigens. Thyroid, 2004 Nov; 14 (11): 964–66.

Corapçioğlu D, Tonyukuk V, Kiyan M, et al. Relationship between thyroid autoimmunity and Yersinia enterocolitica antibodies. Thyroid, 2002 Jul; 12 (7): 613–17.

Molina V, Shoenfeld Y. Infection, vaccines and other environmental triggers of autoimmunity. Autoimmunity 2005 May; 38 (3): 235–45.

Tomer Y, Davies TF. Infection, thyroid disease, and autoimmunity. Endocr Rev, 1993 Feb; 14 (1):107–20.

Wentz, Izabella. Hashimoto’s Thyroiditis: Lifestyle Interventions for Finding and Treating the Root Cause. Wentz, 2013: 238–241.

Is Candida Causing My Health Issues?

By Dr. Justin Marchegiani

What is Candida?

Candida can be at the root of chronic health issues, chronic fatigue, and digestive issues. It can also be a sign that there are deeper underlying problems, such as a parasitic disease (e.g., giardiasis) or a bacterial infection (e.g., H.pylori).

Candida is a microbe that falls under the category of fungal infection. There are a variety of other microbes underneath the infection umbrella, as well, that can attack the body. These include bacteria, parasites, and viruses. Any of these can be stressors for Candida or other fungal infections and can drive health problems, including a leaky gut.

There are many species of Candida, including Candida krusei and Candida albicans. Candida albicans is the more common species. It is the one that typically causes jock itch, yeast infections, athlete’s foot, nail fungus, and even dandruff.

Candida can stress many areas of the body, including the adrenal glands, liver, and brain. And Candida with other stressors, such as endotoxins, bacteria, gluten, and food allergens, in the intestines can cause a leaky gut.

Candida & Adrenal Glands

Candida and other fungal infections put stress on our adrenal glands. Our adrenal glands sit right on top of our kidneys, and these glands deal with inflammation. The stress and inflammation caused by a Candida infection will force our adrenal glands to come to the rescue and help heal all that inflammation in the gut and the body.

The adrenals produce cortisol to get rid of a lot of this inflammation. Imagine you have a smoldering fire. The adrenals are like the fire hose, and the cortisol is the water that’s going to extinguish fire in the gut.

Candida & Liver + Brain

Candida can produce its own toxins. For instance, bacteria produce a toxin called lipopolysaccharide, or endotoxin. Candida, and other funguses, produces mycotoxin.

Mycotoxin creates a by-product called acetaldehyde. Acetaldehyde is a stress on the liver. A lot of my patients say that when they eat bad, they kind of feel drunk. Typically, that’s the effect of the by-product acetaldehyde on the liver.

Acetaldehyde then creates a compound on the brain called salsolinol, which can affect the substantia nigra of the midbrain and the cells that produce dopamine. This can potentially cause vertigo-like symptoms, dizziness, and even Parkinson’s-like symptoms.

Candida & Intestines

A healthy intestinal tract is lined with microvilli and contains junctions underneath that are nice and tight. These junctions are the mechanism that provides the barrier between the inside of the gut and the blood. When Candida is present in the gut, it’s going to put stress on the gut lining.

On deeper inspection, we might also find bad bacteria, parasites, and viruses. All of these things adding additional stress to a Candida infection can cause our tight junctions to open up, allowing those undigested food particles, bacteria, and even Candida to slip into the bloodstream.

If you need help getting rid of your candida, click here!

candida in the intestines

Candida Disrupts Peristalsis

The mycotoxins Candida produces will also disrupt peristalsis, a wavelike contraction in your large and small intestines that helps force out your stool. This will prevent regular bowel movements. If you’re not pushing out about twelve inches of stool every day, you’re going to start to reabsorb a lot of these toxins.

One of the big things we see with Candida is constipation due to mycotoxins, and constipation leads to autointoxication. Auto means “self,” and toxicating means “poisoning.” So you’re poisoning yourself, which is going to lead to more issues with leaky gut. This is one of the biggest mechanisms behind autoimmune disease, which we don’t want.

Diagnosing Candida

There are three methods we typically use to diagnose a Candida infection:

  • Blood test
  • Stool test
  • Clinical signs and symptoms
  • At-home test

Blood Test

A blood test tends to be a pretty good mechanism to look for the presence of Candida. When I look at the blood, I look at IgM, IgG, and IgA. IgM and IgA will reflect a more acute or active issue or infection. The blood test is an indirect measurement. It looks at the response of the immune system coming to the rescue of the infection, so it looks for the fighters that would typically attack Candida, not necessarily the actual infection.

Stool Test

Candida is hard to find in a stool test. We’ll try to culture the stool and see if it comes back positive. If it does, it means you definitely have a Candida or fungal issue. If it comes back negative, it doesn’t necessarily rule it out.

With both lab tests there can be a decent amount of false negatives. If it comes back negative, there’s a good chance it’s a false negative. There aren’t many false positives, so if it comes back positive, it’s there.  In my opinion, a more accurate way to diagnose a Candida infection is through clinical signs and symptoms.

Clinical Signs and Symptoms

What exactly are clinical signs and symptoms? We’ll make observations and ask a variety of questions.

  • Do you have a lot of flatulence, and is there a lot of odor there?
  • Does your bedroom have a yeasty smell to other people?
  • Do you have a history of jock itch, athlete’s foot, or yeast infections?
  • Do you have skin rashes? Not psoriasis, eczema, or dermatitis—more of a blotchy kind of rash that doesn’t really rise up. That tends to be more of a fungal rash.
  • Do you have orange or yellowish fingernails or toenails?
  • Do you have chronic dandruff?
  • Does your tongue tend to turn white? This is called thrush, and it’s the ultimate symptom. It can be a subtle white, pure white, or anything in between.

Clinical signs and symptoms are the gold standard—if we see the clinical signs and symptoms of Candida, it’s there.

At-home Test

You can also take this free and easy at-home test to check for the presence of Candida:

candida yeast test

Treatment Options

If you have chronic Candida or fungal issues, the diet is the best place to start. Read The Fungus Link by Doug Kaufmann.

The following are the essentials for the antifungal diet:

  • Good fats and proteins
  • Carbohydrates primarily from nonstarchy vegetables
  • Avoid most nuts (including peanuts)—almonds are OK
  • Cut all grains, legumes, and dairy (except grass-fed butter)
  • Eat only low-glycemic, low-sugar fruits (e.g., berries, green apples, grapefruit, lemons, and limes).
  • Minimize, don’t cut, sugar (a little is necessary because without it these funguses can form into cysts or spore-like states that make it harder to kill them)

candida killing foods

Herbs like grapefruit seed extract, undecanoic acid, various Berberines, and oil of oregano are good options. The key is to use them in high enough dosages. Typically, taking two or three can be a great combination.

Finally, we have to make sure deeper issues, or infections, aren’t present because we can treat Candida, but it won’t do any good if you also have a more serious underlying infection, such as a Giardia parasite. You have to pull a weed out at the root. If you don’t pull it out at the root, it’s going to grow back. We have to treat the underlying issue, or you aren’t going to get better.

If you have chronic gut issues, health concerns, or adrenal fatigue that you feel could be driven by Candida, reach out and schedule a consult to learn about your options. If you need more help getting to the root cause of your chronic fungus, click here.

The entire contents of this website are based upon the opinions of Dr. Justin Marchegiani unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Justin and his community. Dr. Justin encourages you to make your own health care decisions based upon your research and in partnership with a qualified healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Dr. Marchegiani’s products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using any products.