Blood Sugar Issues and a Weaker Immune System – Blood Sugar & Virus Connection | Podcast #278

Hi everyone! Today’s podcast talks about blood sugar and immune system issues. Diabetes marks the second spot today in comorbidities, and more information about blood sugar regulation is coming right up. With current health concerns, it is also important that we know why our immune system weakens and how we can make it stronger. We have different kinds of viruses and infections everywhere, so we really want to lay down all the important information about having a strong immune system. Join me and Evan Brand in this podcast. More info below.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

0:52     Diabetes

6:46     Glucose and Immune Function

11:43    Metabolic Side of Stress

18:38   Diets, Vitamins and Supplements

27:21   Flu Season

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Dr. Justin Marchegiani: Hey guys, it’s Dr. Justin Marchegiani here I’m with Evan Brand. Today we’re going to be chatting about blood sugar issues and the immune system. And of course, we’ll connect it to the corona virus here today as well. We want to make sense of why our immune system may be weak and how we can accelerate it and improve it. So we can deal with all kinds of different viruses and infections, including the corona virus. Evan, how are we doing today, man? 

Evan Brand: Hey, I’m really excited to chat with you about this. We’ve been looking at several different charts and graphs, there’s just so much stuff to keep up with. There’s just so much data, they could even be overwhelming for us, you know, just because we’re looking at so many different numbers from so many different places. But one thing that’s consistent across the board is we’re seeing that people that have comorbidities are ending up in a more critical shape. So specifically diabetes is second on the list. Heart disease is first on the list. So that’s pretty interesting because diabetics are [inaudible] is in America, and arguably were one of the highest diabetes incidents of any country out there.

Dr. Justin Marchegiani: 100%. And there’s a phenomenon in our body that our immune system uses is called phagocytosis. And phagocytosis involves like our macrophages and monocytes gobbling up viruses. So imagine a PAC Man or a PAC woman, and they are literally just basically grabbing various bacteria and viruses. And it’s gobbling it up now, when it invalid. So basically, it gobbles up a virus imagination, meaning it’s like you taking food and you swallowing it, it’s now inside of your body and your body digest it, your immune cells to the same thing with viruses. And when you have high levels of insulin, insulin actually decreases that process. It’s kind of like if you’re nauseous or sick, you don’t want to be swallowing or eating food. Right. Therefore you can’t digest the food that you’re eating. Well, it’s kind of like that with your immune cells. When your immune cells have high levels of insulin, it’s going to be harder your immune cells will be nauseous to a lot of that bacteria and viruses and won’t be able to digest it and break it down. Now really important because that process requires that process is decreased when there’s high levels of insulin. Now, insulin helps blood sugar go into your cell. Why does insulin go high? Typically, there’s too much carbohydrates and or inflammation. Usually, it’s a combination of the two, of course, more carbohydrates and insulin to go up, the more refined and processed the carbohydrates are, and of course, more inflammatory that carbohydrates are. So some people may have a big insulin spike with grains because one grains will eventually break down to carbohydrate and glucose in your body, but also, the more inflammation the grains cause, especially if you’re gluten sensitive, that may create a cortisol spike and mobilize even more sugar, right so carbohydrates kind of bump up your sugar, but you’re immune response and inflammatory response to it can even increase it even more.

Evan Brand: So it sounds like there’s multiple mechanisms against you in this aspect. And so you really want to go lower carb right now it sounds like it’s just a smart, protective. I would just say anything you could do to lower risk right now it’s going to be smart. So that seems like one thing that’s pretty low hanging fruit 100%. They’ve been studies where they look at diabetic patients, and they actually lower their insulin levels, trying to see if I can find a good study on this. Yeah, here’s a wonderful study. Okay, here Well, I’m going to tell you why you’re pulling that up. I’m going to tell you what I saw over the weekend, which was a video from a doctor who had reported that out of I think it was 23 patients that were in his unit that were in really bad shape. 19 of those were confirmed diabetics. So 19 out of 23 that were in really bad shape, confirm diabetics. So, to me, that’s pretty telling and I’m sure there’s bigger numbers out there. That’s a pretty small patient group, but still still helpful to to have that data.

Dr. Justin Marchegiani: Exactly. Let me go show you guys. So if you guys are listening on the podcast, we also have a YouTube version of this as well where you can see the actual video. So that’s important. So if you guys are driving, don’t worry, we’ll put the YouTube link down below. So if you want to watch the video you can, I’m going to share my screen Evan so you can see. So this is really interesting here. Let me just show you all this. So what they’re actually showing here is this. You can see here’s the ingestion rate, this is your your neutrophils and or your phagocytosis happening by your macrophages. So this is ingestion. So this is like your immune cells eating stuff. And this is blood glucose. So as you can see, as your blood glucose goes up, what’s happening to your white blood cells being able to eat these viruses and bacteria, it’s dropping. Do you see that trend there? So you can look here, let me just kind of draw it up for you guys so you guys can see it and it makes sense. I’m going to make sense of this all so you can see the general trend is this. It’s down. Now again, these are really high blood sugar range. Just 300 400 500 but you can see, even at 100, hundred and 10 that trend already starts. So let’s say your blood sugar only goes to here, like 151 60. Well, you’re still having a decreased immune function, right?

Evan Brand: Yeah, I mean, I’ve had instances where I’ve taken my blood glucose after doing like rice, for example, in the blood sugar can go up into that range for sure.

Dr. Justin Marchegiani: Yeah, and the thing is, if you’re eating every four hours, or you’re drinking a lot of alcohol or soda, you’re constantly jacking your blood sugar up, right blood sugar is going up chronically, which is then driving your immune system down. And again, you have to be you know, kind of more in the diabetic range to get over in these levels. But it’s, you know, it’s not impossible for someone to go up to 151 6180 acutely after a meal. And then if you’re chronically consuming excess carbohydrates, refined sugar, processed grains, you can Keep your immune system your blood sugar a little bit low. And that could keep your immune system. You know, if you’re at this ingestion rate over here of let’s say 75 or 80, and you drop it down, let’s say to 65. Well, guess what? That’s like a 30% drop in your immune function that may be just enough to get you sick. Does that make sense?

Evan Brand: It does makes perfect sense. Well, of course, autoimmune to right, if you have some autoimmune diabetes stuff going on, I’m sure that’s gonna play into this. We’re talking just stuff that you could easily do and try to help support if you’re in the type two category, but type one would still apply.

Dr. Justin Marchegiani: Exactly, yep. And this is you know that a lot of different studies on this, that are looking at that or looking at glucose. In immune function. This is pretty common. So it’s really important to be able to know there’s a connection. And again, a lot of these studies connected to like diabetes or type two diabetes, which is fine, but there’s an in between area between having healthy glucose levels and being diabetic and alive. People are in this pre diabetic, whether we call it there’s starting to be this insulin resistance, it’s subclinical, it’s not at that 126 milligrams per dl of blood sugar, you may be just chronically above 101 10. And what does that mean? You may not have a 20 or 30 or 40% immune reduction, you may just have like a 10 or 20%. Right? And then that may be enough to get you sick.

Evan Brand: Yeah, that all counts, though, right? You may say, Oh, well, 10% reduction, but I want to do anything I can to to build myself up and reduce risk.

Dr. Justin Marchegiani: 110%. So there’s a lot of studies on that, and I’ve talked about it. That’s why right now, if you’re worried about Oh, Corona virus and other viruses, right, you really want to have your blood sugar under control, so leaning more or lower carbohydrate will be helpful. Also a lot of the inflammatory films that are produced from the immune reaction, right so when your immune system goes to fight a virus or if I fight infection, it it produces these inflammatory Well, it produces cytokines to go after what’s happening, right? These cytokines create an immune response. And typically there may be lippo polysaccharides that are produced from the infection. And so what happens is these lipid polysaccharides also can create inflammation. And some of the byproducts of the inflammation that are produced are these things called inflamasames. They’re like inflammatory compounds. And what happens is these things inhibit nitric oxide and nitric oxide is really in it blocks nitric oxide and it suppresses certain toll like receptors so dark pigmented fruits and vegetables are gonna block the LPS are that bad bacterial toxin that activates a lot of those inflammatory so doing bioflavonoids elderberry. Lots of high quality fruit vegetables, especially lower sugar on the fruit ranks. We talked about how high sugar stuff can decrease your phagocytes right? So we want to make sure that We’re on top of that, and we can decrease a lot of that immune response. Right. So the more refined and processed your carbohydrates are, when you make a lot of these cytokines, it’s possible that your body is going to have a increase inflamasome activity, so we can really modulate it. So think of a lot of these compounds and bioflavonoids, we talk about, like adaptogens for our immune system, or adaptogens for our adrenals. This is like adaptogens for like the cytokine response in your body, which is really helpful.

Evan Brand: Yeah, and I don’t know how powerful that would be like eating a handful of blueberries, versus doing like Japanese knotweed or some of these other side of kind of herbs that we’ve discussed. But to me, it’s all on the table at this point.

Dr. Justin Marchegiani: Yep, exactly. I mean, you’re going to eat anyway, you’re not going to just you know, get your calories and your nutrition off of herbs, right. It’s not going to happen, but can you use good herbs and nutrients that are supplemental for the immune system along with you know, fresh blueberries or really good quality bioflavonoids that are going to be in your vegetables and low sugar fruit. Yeah, I think so. And then of course, leaning more on on the lower carbohydrate side and improving your ketone levels, because ketones one, they’re going to want to keep your immune system or they’re going to keep your you satiated. And to ketones don’t have an effect that I’m aware of clinically of decreasing an immune response. And actually, your body tends to increase ketones when you get sick. Let me let me walk you through that. So when you get sick, what tends to happen, you tend to get more nauseous, right? And then the nausea does what it prevents you from eating, right? And then what is the eating? Do you actually start going into what I call starvation, ketosis, meaning you’re not getting enough calories, but you’re also going into ketosis, too. Now, that may be more on the severe side, right? Because your body’s trying to one not worry about digesting food, it’s worrying about digesting bacteria and viruses. Now that’s more when you’re sick. But what about the in between? Can you start to push your body a little bit into here? ketosis so you’re starting to do some cellular autophagy and clean up some junk in your body. Yeah. And with the with the ketones be fueling the weakened immune response like sugar would know they won’t be they won’t be right. And we talk Sugar. Sugar is typically sucrose, what sucrose, usually it’s 50%, glucose and fructose or 55 45 of its high fructose corn syrup, 55, fructose 45, glucose. So all that gets broken down into the same thing. 

Evan Brand: It’s a big metabolic stressors, the key point here and so any stress in the bucket, we’re trying to analyze those. So we’ve talked about immune stressors. We did a whole podcast on different herbs to try to help calm the nervous system, because that’s part of the stress. Now we’re talking about the metabolic side of stress. So really, I mean, if you think of this whole thing as a spiderweb if we look at someone who’s getting critically ill, we’re thinking they may have emotional stress in the bucket. They may have metabolic stress in the bucket. You know, the dietary stress, they may not be sleeping well because they’re up all night watching TV for example. So They’ve got that melatonin cortisol disruption, which is also very impactful on the immune system. Because we know Melatonin is a super powerful antioxidant. It’s one of the most powerful known to man, and produced by the body. So to me, if you’re trying to look at all the data and you’re thinking, Okay, what can I do? I think the wise decision is try to look at these puzzle pieces, look at the spiderweb and try to systematically approach each of these categories making sure you’re getting to bed on time, like I put my little girls down and I go to bed kind of early. I know I go to bed earlier than you Dr. J. I go to bed like 9:30 10 you know, at the latest, sometimes even nine o’clock and then the winter when it’s dark. I may even go to bed sooner than that. So So sleep is foundation one and then foundation to get into doubt delta and focusing on your good quality fats to stabilize that blood sugar will still do some carbs and starch right, like well, we’ll do rice maybe once a week. We’ll do some potatoes maybe once a week. But other than that, it’s mainly good meat. Good fat. That’s good veggies, nuts and seeds. And then the herbals, vitamin C is not an herbal but vitamin C, some extra vitamin D, that stuff is all being used now in New York, you and I were talking about that earlier before we hit record that they’re starting to implement some IV vitamin C into some of these critical care facilities, which I think is a very, very smart idea.

Dr. Justin Marchegiani: 100% and also with the hydrochloric when alone protocol with the as the term is and the Z Pak, the doctors that are actually doing even better are adding about 230 milligrams of zinc to that protocol. And some that are even doing better also add in the vitamin C. So again, we always look at the immune function. Drugs are never essential to the immune system but nutrients are so that’s why leaning to extra zinc, or extra vitamin C, let’s say your diets great and you’re already getting a lot of those things. That’s awesome. But if you do get Exposure to something having more of those nutrients could help your immune system deal with that stress better, especially things like vitamin C, because there’s so much research on those at higher levels being very beneficial. And even if you were to get sick, your body’s gonna blow through those nutrients at a higher level. It’s just like, okay, now your drag race in your car, well, you’re gonna go through a lot more gasoline than you would if you were just driving normally, right? So you have to look at how you run in your body, if your body is already sick, or you’re under immune assault, right? You really got to bump it up even more so you can decrease exposure to the virus.

Evan Brand: Yeah, that makes sense. So, and someone who’s already stressed too, we know just by looking at organic acids testing. I mean, I would say 95% maybe your numbers a little different. 95% of people that we’re testing clinically are showing really low and a lot of nutrients. So amino acids, various nutrients, like vitamin C will show up low all the time. So to me, you may say that, Oh, this is extra supplementation. But to us, it’s kind of just baseline because so many people are deficient. So we’re actually implementing those already, even if this weren’t going on.

Dr. Justin Marchegiani: 100%. And I see a lot of doctors out there that are throwing a lot of doctors under the bus that are recommending immune nutrients and our immune support. But frankly, there’s two differences in care. There’s differences when we’re working with someone in care, and we’re testing certain nutrients and we’re being more specific, and creating a longer term plan. But then there’s even with patients a palliative approach where we may upregulate our immune system for an a more acute response, like if someone’s going to be having more stress or they’re going to be flying on an airplane, or they’re going to be around people that are potentially more sick. That’s a difference to the protocol, we’re going to be having more of a palliative immune boosting acute approach. This isn’t more of a long term program. It’s more of an acute response because your body may be under more stress right now. And it’s just trying to increase our terrain and our reserves, so we can deal with something more severe Specifically, so a lot of people get very dogmatic and want to nuance this and make it more difficult than it is. And of course, different people need different nutrients. But there’s also general approaches that we can use across the board to give ourselves a little bit more of a bump across, you know, the population without having to see each person as a patient test everyone.

Evan Brand: Right, right. I mean, my thought of it is kind of like a road trip, you’re not going to start a road trip with a quarter tank of gas. If you know you’ve got a journey ahead, you don’t really know how things are going to end up. Why are people close to you going to get affected or not? It’s going to be wise to go ahead and fill up the tank with nutrition now, even if you’re someone who has zero concern, zero fear, worst case scenario, you know, something did happen to you, but I think it would be wise to just it’s a prep, it’s sort of prepping your body prepping your immune system, prepping the metabolic system, prepping the nervous system. Like last week, we did a show all about that. different herbs that we love and use to help with the nervous system. All of it counts.

Dr. Justin Marchegiani: Also, when You get exposed to put infection your needs go up. So ideally, you’re already nutritionally supported in a way where your vitamin A Levels are good, your sea levels are good, your D levels are good. So when an infection hits you, it literally bounces off you it can even gain a foothold into your body, right? We know the corona virus uses that h2 receptor site, and it gains a foothold in uses this like filament to drop off the RNA inside the cell. And then it replicates and then you have an immune response. But if we can even prevent that pesky little mosquito from from dipping its nose into that Ace to receptor site, then that prevents this whole issue from happening. So it’s keeping your immune it’s like kind of like, Hey, we’re going to replace the locks on our door. We’re going to maybe put a ring camera out there, you know, I may put an ADT sign or something to make people feel, you know, hey, we’re watching this, this receptor site this home a little bit better, and it may prevent someone from even accessing the home or the cell. Does that make sense?

Evan Brand: That’s a great analogy. I love it.

Dr. Justin Marchegiani: Yeah, so there’s two ways to look at it. Hey, you get sick. How do we have a stronger immune response? But number two is how do we just prevent that invader from even opening the cell door to begin with? And so we kind of want to look at it from two sides of the coin if we can.

Evan Brand: Yeah, and of course you can’t sign in blood and say, hey, look, if you do all the right things, you’re going to have guaranteed protection but to me, it makes sense that you could reduce risk I mean, if we look at just try to comparatively look at vitamin D levels and the flu we know just by looking at the data you can see in general, lower vitamin D equals increased risk. So the data is there on this this is not stuff we’re just making up on the fly to sell some vitamin D you know it’s there.

Dr. Justin Marchegiani: Yep 100% and also, the patient’s got a road in here well what this fasting help well, depends. If you’re sick fasting can definitely help but we still want nutrition to come in. I would just lean in maybe on some collagen, amino acids smoothie, or maybe even just some bone broth or some gentle soup. Because when you when you are sick, your immune system just kind of doesn’t want to work as well because It’s mobilizing that energy right? When you eat food half of the energy that you take in goes to the digestion process. It’s kind of expensive. I use the analogy of using your credit card and having a 50% transaction fee on it. Hey, you buy $100 pair of shoes. Well you get a bill $50 after the fact right, that’s, that’s expensive. So if we can break everything down and make it easier on the tummy, or even go a little bit lower calorie for a day or two, but do it in response to your appetite dropping and nausea occurring if you’re not having a whole bunch of nausea or appetite drop, listen to your body, but you can always do a little bit of fasting. But try to make sure if you’re not nauseous to get enough nutrition, right extra nutrients, potassium, vitamin C, proteins, fats all that’s going to be great and if you start to feel your appetite going down, you can lean into a little bit more of a fast but you know still rely on easy to access nutrition from bone broth or collagen, amino acids or some simple smoothies.

Evan Brand: Yep, you said it best once on a call. Which was that? If you said there’s no nutrition and starving, so you kind of have to weigh that balance of potential benefits and things getting upregulated, maybe more ketone production, versus Hey, I’m just not having the blueberries and all the nutrition to me, I would still say go three meals a day, maybe you eat dinner at six, and you don’t eat breakfast till eight. You know, that’s a 14 hour fast. I mean, that’s plenty long enough at this point,

Dr. Justin Marchegiani: Exactly a lot. Now, again, the less sugar and carbohydrate you need, you actually need less B vitamins and less antioxidants because the more glucose and glycolysis that your body has to run, it actually requires more vitamins and more magnesium, so your nutritional needs will drop. But if you ain’t really getting enough of those nutrients in you’re still going to need some of them. Okay, so get to them. And there is important, a lot of the carnivore crew, they don’t get a lot of those nutrients. But if you’re carnivore, you’re also going to be leaning on lots of grass fed nutrients. And if you’re eating healthy, quality steaks, there’s a lot of biotech cumulated nutrition those animals are going to get from those plants. So it’s totally different if you’re eating animals that are all grain based versus ones that are more grass fed. So if you’re going to be leaning more on the keto or even carnivore side, just make sure that animal products are high quality.

Evan Brand: Yeah, one thing that some clients have said to me is that they, of course, they’re not glad that stuff is shut down in the city. But I have had some people tell me, Hey, now that I’m forced to cook meals at home, it’s actually allowing me to get into new paleo cookbooks that I’ve had sitting on the counter or try these new recipes for this grass fed steak or try, you know, cooking some brussel sprouts for the first time. So I want to try to, you know, put some positive light into this that people are with their families, hopefully at home, they’re eating more good quality food, you know, when everything is running, normally, people are running out and they just don’t think about it. I mean, even when I talk with William Shaw, you know, the head of Great Plains Lab, you know, here he is running a laboratory doing it. Vance testing, and I get him on the podcast. And I’m like, yeah, take us through your diet. He’s like, Oh, I eat out for lunch every day like no bill, don’t eat out for lunch every day. So I guess you could do Chipotle and other higher quality things. But in general, now people are cooking at home or so I’m hoping this is really encouraging people to, to focus on nutrition more. And I think it’s it’s been a real big wake up call for the general population that, hey, our health does matter. And we kind of waited for a crisis to focus on building ourselves up. But obviously, this is not the way I would want it to turn out. But it’s interesting now that people are wanting to wake up and think more about the choices they’re making on a daily basis, like, oh, maybe I don’t want that alcohol because I know that alcohol is not good for my immune system. You know, people are just starting to, to care more, which there’s got to be some good out of that. 

Dr. Justin Marchegiani: Exactly. And then first thing is we talked about the immune system and cortisol and stress. So this video, we’re not going to go into the stats on what’s happening with Corona virus. I’ll do a video after this one where I go into the statistics of it. But let me just frame it a different way. All right? When it’s all said and done, the mortality rate of this infection is far below 1%. Number one, number 290 percent of people that get this infection are going to be asymptomatic. That means for every 10 people, or every one person that gets the infection, nine out of 10, minimum, maybe even higher. Doctor shots out of Ontario says maybe up to 20 people. So for every one person that gets it 19 to 20, are going to be asymptomatic as low as nine to 10 will be asymptomatic. That means your body got exposed to the virus, it’s maybe it’s having an immune response and you’re showing no symptoms. So in other words, there’s a 90 plus percent chance that you’re asymptomatic. And number two is, if you get sick, and you actually have symptoms, 80% of those symptoms are going to be very mild. So in other words, if you kind of look at the 90% chance, right and then you tail it with the 80 percent chance if you actually show symptoms, that’s a 98 to 99% chance that if you get this virus or get exposed to it, you’re going to virtually have very little problems addressing it, and you have a 90% chance that you won’t even know you got it. So that’s pretty awesome. So when you look at all the history and everything that’s happening on TV, you have to know those stats to begin with. And then the first thing I say is, am I doing more than 90% of the population? Or am I doing more than the 10% of the population that that’s really 10 or 20%. Out of that out of that population is getting sick? Am I doing more than 10 to 20% in regards to my immune system, and health, and I would say if you’re doing the right stuff, you’re going to be in that 99% category, for sure. Now, you’re going to see lots of anecdotes on TV of one offs of people getting sick. Number one, you don’t know their health history, too. You don’t know their diet. You don’t know what they eat. You don’t know if they have any other pre existing conditions. You don’t know any of that stuff. So the problem is, you’re not going to have access to a lot of it. And the majority of people are going to be 75. And often have multiple comorbidities like 99% of people in Italy had. So if you look at it, if I say, Oh my god, you have a 1% chance of dying, right? And you’re going to feel something. And if I say, My God, you have a 99% chance of not even having an issue at all, you also feel something with your body and your mind immune wise. So let’s flip it in our brain and look at it like from the 99% chance, and that’s not a 99% chance of living. That’s a 99% chance that if you get it, there’s no issue at all. It’s totally over your head. You don’t even know what’s going on.

Evan Brand: Yeah, and and we’ll wrap this up, because I don’t want to get too deep into this part, but I’ll do mine. 

Dr. Justin Marchegiani: That’s very important, though.

Evan Brand: Yeah. Well, and yeah, and I agree with you, but what I’m going into is different and I don’t want to go off into a tailspin. But one thing that I’m noticing is that the media is focusing on Law on specific naming of people. So this celebrity has it that celebrity has it that celebrity has it. And it’s almost too, as if it’s to create, I don’t know, more fear because it’s like, oh, I know that person. They think they know that celebrity, if it’s patient 367 you’re kind of like, oh, man, that’s bad for them. But if you’re like, oh, Tom Hanks, it’s sort of, I think creates a more visceral response. But as you mentioned, Tom Hanks has diabetes. I just read an article this morning about Oh, yeah, having diabetes or being diabetic. I don’t know if he’s still fits the diagnosis or what but So, as you mentioned, just a minute ago, you lose sight of what else is going on with people. So it’s really easy to compare and think I’m a human, very human. But if they’re diabetic and their diets not good, and they’re traveling internationally, I mean, he was in like Australia, I think, you know, traveling. However many time zones to film for a movie, you can’t compare yourself and your situation to them and think that you’re just as vulnerable as them. It’s just not fair to yourself. It’s not fair to yourself to try to say, because that happened. That’ll happen to me. Because if you’re at home, you’re quarantine, you’re eating good food, you’ve got your nutrition on board, your your extra supplements on board to me. I would try not to worry unless there’s an urgent need to worry if that makes sense.

Dr. Justin Marchegiani: Correct. And then, you know, like you mentioned, when you go into these one off kind of anecdotes, you lose perspective. And so like I always like to give perspective because it gives you a frame of reference to go back to. So this flu season right now. We’ve had 155 pediatric deaths due to flu. How many of these pediatric deaths have been, let’s say they did a a one off story on that person dying of flu, a 15 year old or a 13 year old or a 10 year old kid dying of flu, you don’t hear any of these things with the flu. All right, and that just tells you right now, if we’re comparing our apples to apples. There is an agenda by the media, to hyper focus on this and to hysteria is the issue. If there wasn’t an agenda, show me all the photo ops of all the other kids of flu dying, show me those stories, okay, they’re not there. And the reason why they’re not there is because people are trying to create a lot more fear in general a lot more fear and also decrease, you know, the relative risk on other conditions that happen all the time that we live with. And we’re very comfortable with it happening and we know what happens, right? And that’s the whole the pediatric fluids and it’s 155 dead so far this year.

Evan Brand: Yeah, it’s not good. It’s not good. I wish I could change things. But I guess all we can do is try to help provide just a little bit of a different perspective than just the headlines. And hopefully that can help people to just get through this and we’re all in it together. Unfortunately, everybody’s affected globally. You know, we’ve got clients all around the world, Justin, I work with people in Australia and Canada and Europe, and and it’s the Same there too. So it’s not just a US thing. Now at this point, you know, everybody’s involved. So we hope to just help everybody keep your heads up and keep pushing forward.

Dr. Justin Marchegiani: And also with the comparison, I don’t want to minimize any of the 155, the data flu, that are pediatrics that are kids that that’s already sad, but just know all the information we’re providing today is going to help you from all conditions. It’s not like, hey, this, this supplement is going to just help you for the corona virus of the flu virus, they’re going to improve your immune system, and your immune system will be so much more intelligent and strategic and dealing with all types of immune stressors. So keep that in the back of your head. We don’t want to make light of anything but at the same time we want to compare people’s responses and those responses reveal the the emotional overdrive to get you to feel something more about this versus that.

Evan Brand: Yeah, good point about the immune support right this this podcast will still apply a year from now even if nothing in the media is like this, this this applies all the time. So it Just becomes a little more important now that you focus on this stuff. So, you know, I’ve had some clients to reporting that their their stress eating. I mean, my wife went to Whole Foods and guess what all the cookies were sold out the graham crackers, the cookies, any kind of sweet stuff, you could still get bad food to Whole Foods, it was all sold out. So, you know, even if it’s a gluten free cookie that’s still is that blood sugar metabolic stress we talked about in the beginning. So I would say do the best you can to stay dialed in this is maybe you have a cookie as a treat, but you don’t want to go off the rails too much. Because remember that metabolic stress is immune stress and immune stress weakens you we don’t want that.

Dr. Justin Marchegiani: Exactly. Were there any other questions? I’m sorry. You got any questions? I didn’t have them pulled up.

Yep, so in general a pull it up here. We want to be on top of our immune system. And we also talked about the reason why the fear is so important is because of the cortisol response, like you highlighted that those surges of cortisol will weaken our immune system. So the reason why I am so on top of it and you’re so on top of Because we want to have a strong immune system. And if we can reframe how things how information is exposed to us, like I mentioned, versus the 99% chance of there being no issue at all, even with the infection, then that gets us a lot more hope and that creates a different immune response.

Evan Brand: Yeah. And the cortisol affects the gut and the gut, a lot of the immune system exists or happens the immune system activity can happen from good gut health. So that’s why you don’t want that cortisol damaging that gut barrier. This why athletes after too hard of exercise and may have diarrhea, for example, you know that cortisol can be damaging on the gut.

Dr. Justin Marchegiani: Exactly. Yep. Exactly. And then I’ve Barb writes in about being worried about contacting her 95 year old mother, yeah, just remember, just say that six feet, you know, the corona virus doesn’t have wings, so it can’t fly. It’s an aerosolized droplet that has to make its way over there. So number one, if you’re afraid of being asymptomatic, you could always wear a mask which will decrease the spread out your mouth. For the most part, you’re only going to have a spread if you’re coughing, right, so if you’re not coughing, a man, you’re not actively sick, you’re more than likely fine, you just keep a six foot distance. And then just make sure if you’re going to interact with someone that could be immune compromised, make sure everything’s washed going in there, washed in between, don’t ever touch something. And then if you’re dealing with that person who’s who’s older, make sure they’re washing in between washing after you leave and, and maybe washing down any counters that you may be near as well. Right, but that’d be the biggest thing. And if you’re really concerned above and beyond worst case, you could you could wear a mask if you’re really concerned, but mask really gonna matter more if you’re healthcare people and you’re interacting with people more, or if you are actively coughing or have a cough that you may not be able to control, right. It’s like a cough sometimes or a sneeze, right? Sometimes that can be hard to control. So if you’re in that category where you feel like it could happen then mass may be smart if you have to interact with that person. But that six feet buffer zone will give you a lot of good things. window, I saw the data if you live in the same house as a person, you only have a 5% increased chance of contracting 5%. So it’s not that much more. And if you use good practices and you’re not sneezing, then it gets even better.

Evan Brand: Yeah, I would just say if you’re somebody who you’re having like tree pollen allergies, and everything’s blooming this time of the year right now, then, and you know, you’re going to be sneezing and you’re not sure if you’re a carrier, then yeah, I think that mass would be smart.

Dr. Justin Marchegiani: Yeah. And ideally, if you if that’s the case, I just wouldn’t interact. That’d be even further, just to save that to until things pass. Yeah, yeah. I’ve been using a lot of Instacart for my groceries, and that’s been really helpful because they drop it off. And a couple things you can do is you can do some of the on guard, or feeds essential oil and you can dilute a little bit of that in water and just kind of spray everything. You know, they drop off your groceries, nothing’s really warm in there. You can, you can leave it in the sunlight for like an hour or two and the fresh air will typically kill any viruses as well. And a lot of times the instacart people one they’re wearing masks, and two the You’re actually wearing gloves. So they’re doing a pretty good job on their protocols for picking stuff up. Instacart is going to be a service, that they’ll do the grocery shopping for you. So they’re doing a pretty good job. But if you want to go the extra mile, that’s how you could do it on top of it, I just wouldn’t recommend leaving meats or butter or those kind of things out in the sun, obviously for you know, for common sense reasons. Right. So anything else you want to highlight, Evan?

Evan Brand: No, that’s it. Did you have any other questions that popped up that were relevant? If not, we’ll wrap it up.

Dr. Justin Marchegiani: No, I mean, it’s a lot of things we could talk about in regards to the immune system and what we could do nutritionally but we’ve done other podcasts on that. So I don’t want to be a broken record. So take a look. See, there’s other podcasts for the references on what to do to boost your immune system up. And we’ll try to put some links down below as well for y’all. All right, Evan, today was great. Hey, if you guys are having immune issues, or you want to be more on the preventative side, or you’re like, Hey, you know, I want to start getting my health better. Now what better what better time then everyone being at home and having a lot more time to start working on these things? So feel free head over to EvanBrand.com, reach out to Evan. And then Dr. J myself at JustinHealth.com, feel free, you can click and schedule we’re happy to help you all out. And again, especially during this time, you don’t have to drive to a doctor’s office that could be loaded with lots of you know, flu, other viruses. And this is a great way to start moving forward while you get time.

Evan Brand: Absolutely. We work hundred percent virtually we may not mention that every time but we assume most people figure that out by listening and looking on the website. But yeah, so we send labs to your door, you do those labs, UPS or FedEx picks those up and then returns and back to the lab and then we jump on a call Skype, FaceTime, Zoom, whatever, we then review those and then we make a protocol to get you feeling better. So that’s how we work and we’re very blessed and very grateful for the opportunity and the lab so far. I’ve been doing great with turnaround times. We haven’t seen any lag or delay. We’ve got nutrients that we have stocked up on Justin and I both personally so we’ve got supply which is good. A lot of places are sold out of stuff for immune. So luckily we kind of thought a little bit ahead of the game here.

Dr. Justin Marchegiani: Yeah, and let us know what you’re doing. comments down below if you got the dreaded Corona let me know what you’re doing with it. If you got other infections right now or you’re feeling sick, let me know your experience, what’s working what’s not. And if you enjoyed this stuff, give us a thumbs up, give us a share, let your family and friends know we really appreciate it. We want to empower everyone here.

Evan Brand: Last note, I saw that one Chinese study that came out that 80% of people that tested positive It was a false positive. So that, that’s why the scratch my head.

Dr. Justin Marchegiani: Yeah, I don’t love the idea of the testing because it’s gonna it’s gonna create more numbers and those more numbers are going to create more hysteria, more panic. And I always tell people more numbers actually mean that the virus is actually weaker, because that means the mortality rate actually drops right? But I don’t like the idea that there’s a false positive 50 to 80% of the time. So-

Evan Brand: That’s bad at a maximum 80% false positive. I mean, that is humongous. If we just deleted 80% from the numbers of the cases, I mean, that would that would be unbelievable how different it would look-

Dr. Justin Marchegiani: And then how I how I interpret, that’s a little bit different. How I interpreted is, if you’re around people that could be immunocompromised or are going to be older, go through the extra precautions, whether it’s you quarantine for them. Or you go through extra measures like washing hands, which you should be doing anyway. But maybe you maybe I do gloves, maybe you want to do a mass that you recycle, just to be extra careful, I’m fine with that. Just pretend like you already have it and more for the immunocompromised, more for the elderly. But get sunlight, get some fresh air. If you can leave your house and you’re not in like New York City where things are congested, go in your backyard, get some get some fresh air, get some walk, get some vitamin D, all that stuff’s gonna be great. Don’t be cooped up inside unless you’re of that population risk factor. And you’re in a part of the country where you have to be everyone’s gonna do better getting that fresh air and vitamin D.

Evan Brand: Yeah, and we’re running on your fires like always too. So this would be another good time. If you don’t have air purification, you are trapped inside. Air Purifiers are a good strategy. So we could put some links for that as well. We’ve got a couple of recommendations.

Dr. Justin Marchegiani: In our budget and our air purifiers that we’re recommending will filter out viruses. So if you’re in that area and you’re in someone’s home, right crank up that air purifier. That way it’s gonna clean everything out and less chance of getting more exposure. But again, risk factors are going to be pretty low if you’re doing all the right things. 

Evan Brand: Yep. All right, check out the websites if you need help once again, Dr. J. at JustinHealth.com, me at EvanBrand.com, we’ll be in touch. Well, take care.

Dr. Justin Marchegiani: Excellent everyone. You guys have a good one. Stay safe. Peace. Bye bye.


References:

https://justinhealth.com/

Audio Podcast:

https://justinhealth.libsyn.com/blood-sugar-issues-and-a-weaker-immune-system-blood-sugar-coronavirus-connection-podcast-278

Mood Imbalances and their Root Causes | Podcast #250

Depression, being the #1 cause of disability in the US, has tons of other mood issues that come along with it. Some psychiatrists are not telling what are the things that caused us mood issues,and what should we do to lessen it.

For this podcast, Dr. Justin and Evan Brand talks about root causes to mood issues.  Also, learn through this podcast the importance of blood sugar maintenance, sleep, diet, and a lot more.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover: 

01:15 Moods and Diet

03:40 Blood Sugar

09:00 Sleep

12:20 Chemicals in Food

14:40 Progesterone and Estrogen

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Evan Brand: I’m doing very well. This is an exciting topic because depression is the number one leading cause of disability in the US and there’s a ton of other mood issues that come along with depression and your psychiatrist is not telling you that you need to detox heavy metals and get infections out of your gut and stop eating pesticides and all the other things that are causing a mood issues. They just give you a drug to treat it and give you a Band-Aid which has save lives but it’s not the root cause so we always love root cause. 

Dr. Justin Marchegiani: 100% So let’s talk about some root cause foundational mood stuff first and we kind of have the Nuance nitty-gritty stuff and then we have the foundational stuff. So the first thing is just your diet, right? We need a nutrient dense anti-inflammatory low toxin dietary template and I I like to talk about diets me template. It provides a lot more flexibility and then we have a framework premise and why we recommend the things that we recommend part of it is foods that are evolutionarily appropriate Foods. We had enough time to adapt to eat, food that are going to be low in toxins, whether it’s anti-nutrients are oxalates are five dates or natural plant Oxalis plants have claws and feet to run and Fun Run and fight so they have berries toxins, right? So we want to make sure were using cooking methods and avoiding toxic plants, especially the more got issues we have and that anti-inflammatory, right? We know foods have the ability to move us to an anti-inflammatory environment good healthy, omega-3 fatty acids good healthy saturated fats of the more process refined omega-6 that are more fragile and they can move it move us more in that Pro in from inflammatory State and then of course the nutrient density foods are going to be super nutrient dense B vitamins minerals. Obviously the food quality is now a big deal because you can have the same kind of meat on on your plate. Looks totally different under a microscope because of the hormones because of the feeding practices cuz the medications and the and the drugs given to the animal while they were having their life and growing so to speak. So we have to look at nutrient density anti-inflammatory status and hormones and toxins are the big things off the bat. 

Evan Brand: I’m glad you about this before but we could just bring it up briefly which studies done on prisoners and when they were giving Omega-3 supplements basically fish oil supplements, they had less violence and less just crazy behavior overall and there’s been some like Psychiatry studies looking at just overall like homicidal rage and suicidal thoughts and those things in there directly correlated with a deficiency of omega-3. Fatty acids 

Dr. Justin Marchegiani: Omega-3 is really important. Also blood sugar stability. There’s also data on the fact that’s Information I should say. Are you able to see me hear the screen? 

Evan Brand: Yeah, I see you perfectly.

Dr. Justin Marchegiani: Good excellence. All right, so there’s information showing that. Mood issues anxiety and depression is a result of inflammation in the brain. And we also know that anytime low blood sugar environment can happen right refined carbohydrates blood sugar Spike followed by a drop that’s called reactive hypoglycemia. Those kind of those kind of situations are going to create mood issues and this data on the fact that a lot of violent crimes are committed in a hypoglycemic environment and some of the data on that is because of the fact that low blood sugar and are making shutdown activation of the frontal cortex in the frontal cortex is the part of the brain that’s going to predict the outcome of an action so it can say Hey, you know that person that just pissed you off. I want to go hit him or go call him out. And then that frontal cortex has that like 20 milliseconds of hey, you know, if you do that you may get arrested and it can dampen the impulse so to speak so the more you have good activation of that frontal cortex through reducing inflammation. And then also maintaining good blood sugar and part of that as we become more fat burners and that fat burning environment put logs on our metabolic fire was future blood sugar from going up and down and then avoiding a lot of a refined carbohydrate which tends to make our blood sugar go up and down as well. 

Evan Brand: Well, this is part of the reason people make bad decisions when they go out to a bar into a club and they drink alcohol and go home with somebody that they don’t want to partial partially due to what is alcohol. I mean, it’s basically correct liquid. It’s basically liquid sugar. It’s going to crank up the blood sugar but it’s also going to crank up serotonin and then the serotonin is going to just flat line and when you run out of Serotonin, you can’t make decisions that are smart. And so if you are somebody who is struggling with mood issues alcohol needs to be out of the picture completely for multiple reasons that we just met-

Dr. Justin Marchegiani: Blood sugar or I should alcohol actually lowers your blood sugar can create a hypoglycemic and where I might just go take a for instance a shot of vodka and just test your blood sugar your blood sugar. Drop restaurants do this on purpose because they know if they can get you some refined carbohydrates and pretzels and some bread and then they can get you some alcohol pretty fast. They’re going to cause a reactive hypoglycemia environments and you’re going to be ordering more food and getting more carbohydrates may be ordering a bigger desert whether or not they understand the biochemistry of it all they understand that if they do these kind of things in the beginning of the meal they can create a larger bill for you at the end of the meal.

Evan Brand: Should have clarified like margaritas and things that have like agave syrup and all the sugary stuff mixed with the alcohol. That’s when your blood sugar is going to go crazy, but I haven’t tested the Vodka by itself. That would be cool to see on a glucose monitor. 

Dr. Justin Marchegiani: Exactly yup 100% you can really create some significant significant issues of significant stressor 100%. 

Evan Brand: So we could spend time and talk about this isn’t for today. But I mean, there’s like a traumas for example, you know any trauma that’s left over in your body, you know physical mental abuse or anything like that yet. You must address promise. I don’t want somebody listening and thinking if they just perfect their diet and get rid of alcohol. Their mood issues will go way there could be super deep traumatic issues that need to be addressed but no we were trying to focus on more like the biochemistry aspect the blood sugar affect adrenals hormones thyroid got those things. 

Dr. Justin Marchegiani: 100% Yeah. I totally totally get that for sure. So in general we have the inflammation components to so of course gluten to be a big one there the main mechanism how gluten is in a create more mood issue is going to be through inflammation and it can create gut permeability and that gut permeability can allow various inflammatory cytokines and Undigested food particles to get in the bloodstream that can create more of an inflammatory response and then create leaky brain as well. And then a lot of these inflammatory compounds whether it’s lipopolysaccharides or just inflammatory foods that are unprocessed that you have that immune response these particular can get into the brain but through the astrocytes which of the blood-brain barrier and then that can activate our glial cells in our brain and that can create more cognitive issues more information in the brain and some of the newer families of antidepressants that are coming out very soon. These medications are actually working more on inflammation in the brain problem is like any medication is going to be at have inherent side effects just because of the fact that Any medication does when you block and inhibit various enzymatic Pathways other things happen as a result, like the old vioxx days with these cox-2 inhibitor medications the cox-2 enzyme the cyclooxygenase to enzyme that was being blocked by some of these medications like vioxx. Well, those enzymes also have beneficial effects on recovering liver heart and gut tissue to then you had a lot more stroke and cardiovascular incidences. When you were on this medication. Do you know they worked at enzyme and other important roles outside of just blocking paint. 

Evan Brand: Where they pulled from the shelves. I mean, that’s like long gone, isn’t it? Maybe I should look it up. 

Dr. Justin Marchegiani: Yeah that was pulled like 10 years ago. I make more cat a massive lawsuit around that I think it was on record of killing 60,000 people. Yeah. Yeah. I know really sad but we are going to do you know?

Evan Brand: All right. So let’s talk about the Sleep aspect like for example 3rd shift workers much much higher incidence it personally when you’re working a third shift. You’re messing up your circadian rhythm your serotonin in your dopamine your melatonin your cortisol all these hormones and neurotransmitters that can act as both neurotransmitters and hormones. They all have a circadian rhythm. And if you’re not going to bed with the sun and getting up with the sun, you’re probably not going to be optimally happy now. There may be a few people listening. So I work 3rd Shift for 20 years and Im as happy as a lark. Okay, Mike, maybe you’re unique but as a general human rule going against the sun is not going to result in Good Moods. It’s that simple.

Dr. Justin Marchegiani: Yep, 100% shiftworks a big one. We know that I can definitely Cradle by The Moody she’s partly because we are hardwired to kind of be on a natural circadian rhythm Right light stimulates cortisol cortisol stimulates, you know alertness and and being awake and then that cortisol drop throughout the day and a Miralax at night and darkness stimulates melatonin antioxidant information helps you recover. So yeah, that’s a really important step into this. Equation for sure. So they sleep component, the food the nutrient density component think it’s really big. Lets go to the next low hanging fruit– digestion. Okay, great. Were eating a really good diet. But now we got to actually break down those nutrients those nutrients so we gotta make sure what you and our food up. Well, we got to make sure we have enough acid and enzymes to break down those amino acids. Those fatty acids those cholesterol compounds cuz they are building blocks for a brain is cholesterol and saturated fats are hormones are building blocks from cholesterol as well. And then our brain amino brain chemicals. They’re all going to come from amino acids, which come from protein. So all of our brain chemicals norepinephrine dopamine Gaba serotonin serotonin than Converse the Melatonin which is our sleep hormone and our antioxidant for the brain, they all come from protein. So we really have poor digestion and their studies actually on H. Pylori for instance cant create mood issues. And what’s the major mechanism? My opinion, the mechanism is the fact that you have poor digestion you have less stomach acid. You have less breakdown of these important building blocks and then hes building blocks can be used to make these healthy brain chemicals that allow you to feel good sleep good and deal with stress. 

Evan Brand: Yeah. I agree. I was depressed when I had h-pylori could attest that my mood was not good and I lost a lot of muscle too, I mean you looked at me and you told me Evan man. I remember seeing a picture of you you had some muscles what happened to you. I was so skinny. Luckily. I’ve regained a lot of that muscle back but mood issues are definitely related to gut infections and I just want to talk about kids for a minute because a lot of parents blame their children or just being kids and that’s why they have a bad mood. I’ll tell you as a father of two mood issues are totally related to what’s going on with your kids diet as well and your kids got so if you send your kid to school with crackers and goldfish and other garbage that’s going to be inflammatory. But also it’s going to affect your blood sugar and they’re not having good protein with their lunch. It’s no wonder they crash. I have bad moods and then they are getting in trouble in school in the teachers calling you saying hey, you know Johnny hit another student today. What would have happened if his blood sugar was well regulated and go ahead. 

Dr. Justin Marchegiani: Yeah. I saw my son a picture of him. it’s snack time last week. It was really funny. All the kids are there had their lunch box is open and you could see he had like some green apples that were cut off. He had this like grass-fed organic, like beef jerky. They’re just really easy and Ill kind of cut off and he had I think some little bit of almond butter is a hit a really nice snack and he has seen a lot of the other kids. You see the Goldfish. You see a lot of sugary drinks. I’m like oh man, and these kids are just really getting their blood sugar on a roller coaster ride, and they’re not going to be as good I mean, don’t get me wrong nutritions not going to make your one or two year-old a three-year-old who is developing be a perfect angel but it’s going to significantly improve things and make it much much better and it’s in a provide the building blocks. They need one to heal in to grow their nervous system and connect all these synapses in the brain. All these neural connections from all these new skills that there that they are using but two are keeping a lot of the inflammatory dies and chemicals and Foods out that could make things even worse as well. 

Evan Brand: There’s been countless studies on the artificial colors and flavorings increasing the risk of ADD and ADHD. And a lot of these behavioral cognitive issues that are deemed as common so the teachers, you know, well just recommend that the parents speak with the doctor in the doctor puts the kid on Ritalin and that calms the kid down but that’s not the root cause he there’s a root cause of that and this is not hey, you know, Justin and I are awesome in our kids are better than you but I’m just telling you I’ve seen it my daughter hanging out a plate at a playground versus other kids where other kids in the same age group are having emotional breakdowns and they’re crying and rolling on the floor and screaming and just acting out like not how you think a kid would act out just not in control. Where is my daughter would be controlled or emotions would be controlled. Does she still have outburst and cry? Over silly Small Things. Yes, totally. But she’s three years old at the time of this recording. So I’m just saying that as a general rule, but also the chemicals to write when Im just talkin food. Were talkin that you and I both are you’re giving your son detoxification support. I give my daughter detoxification support. We’ve given both of our kids herbs to help treat gut infections and bacterial and things like that in the gut too. So maybe if the diet is dialed in but you’re not seeing any progress Improvement this applies for adults, but also children since were on the subject run a stool test on your 3 4 5 6 10 year old 15 year old kid and you may find gut infections like the H pylori just to mention as another root cause of the mood issue. 

Dr. Justin Marchegiani: Exactly plus it’s probably incidences where maybe some not-so-great food or more refined processed food slipped in with your child at all. And then you probably saw an outburst or behavioral issue, you know, we had an incident. I think on a birthday. We gave him a little bit of gluten-free cake and there’s a little bit of a crash afterwards we could see that in this by observations from you. So it’s all wrong with it. Right now. We definitely want to provide the hormone environment where it allows our kids to grow in NBA Staples possible think it’s really really important. We hit the the food component the digestion component. Let’s talk about four months. So obviously blood sugar has a major effect on our hormones the more I blood sugar goes up and down the more cortisol and adrenaline to get call to the rescue to to bar for that out to the mortgage Reno stress gets put on our body in archery know our stress handling system and the adrenals are a part of the hormonal system is connected with the sympathetic nervous system. So the sympathetic nervous system is the part of the nervous system that deals with fight-or-flight stress running fighting, fleeing confronting and that part of the nervous system the more it gets turned on or flare the more adrenaline and cortisol and stress hormones that are catabolic the break tissue down or going to be secreted and the adrenals also produce a significant amount of sex hormone precursor. So the more we’re stressed and dealing with the catabolic stress side last week and allocate resources to the anabolic repair and Recovery parasympathetic size. And then it makes it harder for us to recover put on muscle feel good turnover on neurotransmitters and just be able to deal with and adapt to stress. So there is that on one side and the adrenals affect the kind of men and women relatively equally but then women have their hormonal side from the ovaries that cycle throughout the month and that part of the Cascades a little bit more unique because cortisol, which is that major stress hormone that we talked about can also be made from progesterone. And so the more we are stressed, the more we can pull from the progesterone. I was thinking create more estrogen dominance so are relative ratio of progesterone estrogen which is typically 20 to 25 to 1 on average for progesterone Dash inserts asked you and this condition called estrogen dominance starts to occur with a percent of that returns coming up and this can create more mood issues more PMS kind of issues breast tenderness cramping back pain in the mood components of they want irritability anxiety depression. All those symptoms can happen as a result of that. So the more we can take away that up and down with our cortisol in the movie that takes out of that the less estrogen dominance will kick in.

Evan Brand: I just want to point out one key Point you’re speaking about ratios a lot of women come to us and say I’ve got so much estrogen. I’m so estrogen dominant know he’s not saying that you have tons of estrogen you saying in relationship to your progesterone. So it’s not that the estrogen is literally overwhelming and you have more estrogen than progesterone. that’s not what’s happening. Correct, correct? 

Dr. Justin Marchegiani: And it could be that your estrogen is actually really really high. Im seeing with a lot of my female patients is progesterone is low really low acids also low, but the ratio is still skewed. So Im seeing it like if you are as progesterone, right and he is estrogen what’s happening. Both are low, but progesterone is even lower. So it’s like that.

Evan Brand: Are you saying estrogen overwhelmed progesterone or would that be like an extreme case?

Dr. Justin Marchegiani: That being extreme case and almost all the time with cases like that. There may be an exhausting is pit Ashton being taken right? You’re definitely would see on the birth control pill side. You may not see it come back like that because a lot of egestion metabolites me to come back on the test cuz youre not, you know the actual the actual estradiol or estradiol hormone. They’re like the analog that it’s a metabolite that has still in that shouldn’t affect but it’s not coming back in the lab. So we just know the fact that if these levels are that high cuz you’re taking it then the warm out there going to be Might as well.

Evan Brand: OK make sense would be a mechanism to cuz if you had like yes High B6 recirculating all those hormones hormones would just make it works. Right if your recirculating hormones.

Dr. Justin Marchegiani: correct Plastics that I have seen no estrogen kind of facts whether [inaudible] egg. And then of course, you’re going to have hormones in the states right to give it a lot of estrogen type of hormones to make them fatter and kind of woke up. So to speak to the farmers can make more money on the slaughter there is that too. So that’s why you have to mitigate the toxins in the hormones and all the food and then you have to look at detoxification pathway. So well run on the docks tested a little gas gauge in the bottom left-hand corner of stop H3. it’s called the two methoxy hydroxy acid metabolites panel, or I should say reading and it’s a little gas gauge you want to at least in the middle, but you’ll see a lot of decreased methylation so it’s way to the left and that’s a sign that were not metabolizing are Estrogen. 

Evan Brand: Yeah, that’s important. So you have to address hormones and were not saying hey, you just go on thyroid medication. Like that’s not you know, this is a whole system here adrenals are connected to your thyroid thyroids connects. The brains involved. You mentioned the sympathetic nervous system. So if you’re somebody whos working 70 hours a week or not taking days off in your nervous system is so revved up. You can eat a paleo-diet and still have mood issues. 

Dr. Justin Marchegiani: Correct. Yep. that’s very possible. So we have those kind of hormone issue is and of course any women listening to it mood maybe one component of that. It could be other things as well could be the energy you could be back pain and cramping breast tenderness fluid retention. It could be all the above. 

Evan Brand: We should talk about toxicity and liver and chemicals and metals and stuff for a minute. But why don’t we just briefly mention autoimmunity and the role that I could play in hormone. So if you’re someone who has autoimmune thyroid, isn’t it possible that if you’re going from hypo to hyperthyroid, you may have some mood issues associated with that autoimmune attack or some day is the immune system is bang bang and then some days he knew system is not. 

Dr. Justin Marchegiani: So we look at hormones. it’s either ATM or ATF and it’s not you know, the ATM where you get money or the Alcohol Tobacco and Firearms government agency ATM is Adrenals Thyroid Male Hormones, ATF is Adrenal Thyroid Female Hormones. So we already talked about the adrenal and the female and the adrenal and the mail. Yes the same mechanism are as we complete DHEA and we kind of lets just say deplete our sex hormone precursor from the adrenals testosterone can also drop and then testosterone can have a significant mood depleting fact as well. So same on the men the little bit less has less pronounced because women have a hormone cycle that that rhythms up and down throughout the cycle or manner kind of like a flat kind of Foghorn. So to speak there isn’t quite as much rhythmic activity. Therefore it’s harder to knock that off so to speak but now with the thyroid issues women are going to be five times more prone to But men still listen because if you have symptoms, we definitely want to rule out the thyroid like you said just having low levels of thyroid hormone can create anxiety for sure and also having high levels can also create anxiety and irritability and also having Hashimoto autoimmune flares which would eventually end with low thyroid but like you mentioned that autoimmune flare can flare up your thyroid autoimmune response was Canaan cause more hormones to dump in the system, which can then create mood swings and irritability and anxiety difficulty sleeping and that can create issues as well. So you really want to look at autoimmune markers for the thyroid TPO thyroglobulin antibodies. You want to look at your thyroid levels because high or low or going to be significantly driving a lot of mood issues most of the time it’s going to be low because low is The Chronic place that people tend to end up but you will see with a cute flares that it will go high or more in the hyper side again in general. it’s going to be harder to catch that but if we see Levels of antibodies we can definitely assume those level of flares may be happening whether or not we catch the high-level on the test. If we know High antibodies are there then it makes sense that’s possible. And then of course some graves for sure, graves will be the other condition where were making antibodies. Where is thyroid receptor site antibodies are TSI with your thyroid stimulating immunoglobulins those can cause thyroid to make more hormones and that’s an autoimmune condition as well. Get ninety-five. 99% are going to be Hoshis, Hashimoto’s 1% grave. So in general, it’s more plausible. If you’re gambling person that you’re going to go on the Hashi side Less on the graves, but you know, you’ll typically were not going to ever run for Graves antibodies unless we see very high levels of thyroid levels like very high levels of T4 and T3, then we’ll definitely say, okay. Lets run TSI. Lets run thyroid what receptor antibodies.

Evan Brand: Your endocrinologist would probably even run even if you beg them. So a lot of times were ordering Special Labs because the primary doctor that someone may have the working with us. We may try to push them. Hey, you don’t try to get your endocrinologist to run this and they just won’t they’re very stubborn. Even when it comes to the TPO and TG antibodies despite the mass of massive increase even just the past 5 to 10 years of autoimmunity with thyroid. You would think that it’s like part of standard procedure and protocol now, but it’s still not my grandfather got his thyroid Labs run. It was literally just TSH and T4 and maybe like T3 uptake, but still nothing else and it’s just crazy. So what are they doing? They they modified your drug based on TSH, TSH one up. Lets give you a little bit more synthroid and people just don’t know why they’re not getting better.

Dr. Justin Marchegiani: Exactly and then conventional medicine will look at the graves thing and they’ll just say, okay. Well if you’re not in any hormone the right when you come in and your TSH is buried meaning it’s very low and let’s say below point 3.2.1. Then they may want to look Downstream at them some of those antibodies right? They may look at T4 and then I’m a look at TSI in the thyroid receptor site markers, but outside of that unless they see that they’re probably not going to do much. 

Evan Brand: Yeah, hopefully that’s what they do. But in some cases they may go straight to hey, we need to do radioactive iodine and try to just kill your thyroid off because youre youre over your thyroid overactive. I’m sorry that.

Dr. Justin Marchegiani: If they saw grave markers, that would be the next logical step. They didn’t want a thyroidectomy or they give u p t u or more time is all the shutdown of the thyroid activity or they give the radioactive iodine to just kill the thyroid to begin with.

Evan Brand: Not pretty.

Dr. Justin Marchegiani: No it’s not so thyroid flares because of Hashimoto’s well that may never come back on the TSH may never come out of balance enough for it to be an issue and your TSH may still be relatively in range, even though your antibodies are going up and down and your T3 may be low or could be going up or down to so you may not even see a problem with that.

Evan Brand: Alright so let’s talk about that was a good diversion. So I just wanted to make sure we hit. Community Casa del Carmen and no pesticides damaging the gut barrier damaging the blood-brain barrier. Even if you’re a vegan listening, please eat some meat but if you’re not, you know the vegetables or not benign neither you can still get a different herbicides pesticides excetera that still damaged your good gut bacteria and create leaky gut, even if youre saying everything I don’t need hormone me. Okay? Well the plants could do at 2 and then also the heavy metals, you know, we’ve seen a lot there’s just Google it look it up on PubMed your Googles evil because they’re suppressing a lot of help people. So use another search engine like one called ecosia ecosia. They plant trees every time you do a search every 10 searches the plant a tree for you so search on a Ecosia, PubMed Mercury depression or you know Mercury anxiety and any like bad mood something that you type up you can find a correlation with a various heavy metal. 

Dr. Justin Marchegiani: Excellent. I think it’s really really important. So heavy metals various pasta sides various toxins Roundup glyphosate. These are all going to be potentially stressors on your nervous system on your immune system on your brain. I told easiest thing is one just decrease the toxic overload. Just be eating organic higher-quality food. Drink really good clean filtered water. And then number two we can always give support to help run our Phase 1 Phase 2 and R2 toxification Pathways, that’s really important. We could do simple things like activated charcoal with you give sulfur-based Obito acids, we can get glutathione straight into liposomal former reduced form. We can get back Extra B vitamins and antioxidants like milk thistle with cumin and Resveratrol and really powerful things to help with inflammation and in donating antioxidants anything else. You want to highlight their on the detox. 

Evan Brand: I started over the weekend doing some glutathione and a nebulizer. there’s actually a brand out there which I can tell you about a bluetooth ion this mixed with a sodium bicarbonate that you can make Saline solution. I’ve read a Stephen Buhner, the herbalist that you and I love because of his work on Lyme and co-infections. He made a COPD protocol for people suffering with asthma and other lung conditions and came up with a nebulizer protocol with essential oils. And so I’m doing the nebulized glutathione by itself and you just need to put the face mask on you got the nebulizer and I just took a of 200 mg of glutathione intranasally and I tell you my brain yesterday was so clear like, amazingly clear and I’ve actually spoke with some of these people at the company who’ve gotten their patients off of IV glutathione and onto the nebulizer because they don’t have to drive anywhere to get poked with a needle is much cheaper and the results are being seen much better because it’s getting through the blood-brain barrier when you inhale the glutathione vs. IV is not so that’s like my new development on detox and I haven’t done it enough yet to to give you the full, you know the whole story but for right now, My story is very positive. 

Dr. Justin Marchegiani: Excellent. Very good. So I think we talked about some of the toxic things. And again, it’s pretty simple. it’s like you just got to look at the food. Look at the environments try to increase sweating the infrared sauna good clean hydration could get a grill to go clean water filter JustInHealth.com/water or the ones that I specifically used Evan probably has some as well EvanBrand.com and you can look at his shop as well. But that’s kind of things. I actually use and I recommend personally clean water organic food being able to digest your food and then we talked about some of the various binders that we can do like chlorella for that some of the heavy metals activated charcoal as it’s a really good multi-tasker for a lot very spent the night Clays or folded minerals are really good too. And then they also you know from what we may also do things like Z light or maybe even Coley star means to help that bind up some of that mold as well that could be there environmentally if that’s the case then well have to do some testing on the house and and look again. Is the root cause of that Dilantin I have a guest that were going to get on just a few minutes. It will talk all about that in the next podcast. I will be right after this show. 

Evan Brand: Yeah, we got to wrap it up so that you all can chat about mold. it’s going to be fun. But the sauna would be the last thing I would add animal wrap it up the sauna and I love sweating sweating is the key and you can look at if you just look up PubMed typing like ochratoxin sweat. You can read that mold toxins. In fact do come out when you sweat so there is proof behind that and there’s a reason that our ancestors did like sweat lodges and some of these ceremonial practices they sweat their butt often those things and they were probably detoxing too good thing for them as they did not have any of the hundreds of thousands of manmade modern chemicals that we have today. 

Dr. Justin Marchegiani: I think it’s important. that’s great. Awesome animal today was a great chat as always. Hope everyone enjoyed the podcast in the interview before you put your comment down below. Let us know things that you have used to help you detoxify good experience that you had and if you enjoy today¡̄s show, give us a share. We appreciate it, and you can write a review at EvanBrand.com/iTunes and JustInHealth.com/iTunes. We appreciate ya¡̄ll. Everyone has a phenomenal day and we’ll talk real soon.

Evan Brand: The clinical websites. If you want to reach out to Joe is clinically, please do so at his sight JustInHealth.com. You can reach out around the world. We can send test kit’s to your door. You don’t have to drive anywhere and wait in a boring dirty doctors office and read People magazine. You can do it from your house. So JustInHealth.com, and then my side is EvanBrand.com. We look forward to helping you were very grateful for the opportunity.

Dr. Justin Marchegiani: Love it, excellent. Awesome Evan, have a phenomenal day great chat with you is always will be back next week. Thank you. Everyone. 

Evan Brand: See you later. Bye.

Dr. Justin Marchegiani: Bye. Bye.


References:

https://www.evanbrand.com/

https://justinhealth.com/

https://justinhealth.com/water-pitcher

Audio Podcast:  

http://justinhealth.libsyn.com/mood-imbalances-and-their-root-causes-podcast-250

Brain Chemistry, Mood and Amino Acids – Podcast #57

Brain chemistry is the sum of all the chemical messaging that takes place in the brain, which allows it to carry out its daily functions, such as generating movement, speaking, thinking, listening, regulating the systems of the body, and countless others.

Dr. Justin Marchegiani and Evan Brand begin this podcast by sharing patient stories that deal with blood sugar issues and eliminating sugar cravings as well as patientsbrain chemistry
with autoimmune conditions being treated with dietary work and adrenal work. You can reach out to either of them so they can help you put together an action plan on the next steps to do to improve your health. Discover the differences between conventional medicine and functional medicine and how patients’ symptoms are being addressed and what treatments are being given. 

They also get into in-depth discussion about brain chemicals and neurotransmitters. Dr. Justin effectively demonstrates the process of the action potential and the neuro conductivity that take place. Find out how long a person should use amino acids therapeutically in order not to create any deficiencies as Dr. Justin explains it thoroughly in this interview and he tells us what other nutrients you need to be taking while on this type of treatment.

In this episode, topics include:

1:15   Patient stories

8:15   Deeper look into amino acids, brain chemistry and mood

17:45   Difference between conventional medicine and functional medicine

19:45   The length of time to use amino acid therapeutically

24:58   Recommend method to get off medication like SSRIs, etc.

 

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Podcast: Play in New Window|Download

 

Dr. Justin Marchegiani:  Hey, it’s Dr. J.  Evan, what’s going on, man?

Evan Brand:  Hey, not much.  I just finished up some matcha, some organic matcha and schizandra, so I’m feeling pretty turned on in terms of my brain function today.

Dr. Justin Marchegiani:  Turned on.  I like it, man.  That sounds good.  That sounds really good.  Yeah, I’m having–

Evan Brand:  Yeah.

Dr. Justin Marchegiani:  A pretty spectacular morning.  It’s Friday.  It’s–it’s hot.  It’s sunny in Austin, so I mean I can’t really complain.  Actually flying out in a few hours to go up to San Francisco here for the–for the weekend, so I’m pretty excited about that.

Evan Brand:  That sounds good.  What are you doing up there?

Dr. Justin Marchegiani:  You know what?  We’re just doing a little bit of R&R, gonna travel a little bit.  I lived in San Francisco for 5 years so heading back to the old hood.

Evan Brand:  Wow, so it will feel like going home then?

Dr. Justin Marchegiani:  Getting’ away from some of this Texas heat.  Yeah, I know.

Evan Brand:  True.  I’m sure it’s hot.  That’s one thing I’m glad to be back in Kentucky, man.  We’re not burning up like–like I was there.  I was waiting for the snow to come and it never came.

Dr. Justin Marchegiani:  Yeah, well, I hang out in the lake a lot in the summer and that kinda cools off.

Evan Brand:  That’s true.  That’s true.

Dr. Justin Marchegiani:  Go down at the Barton–Barton Creek Springs downtown there, it’s really nice.

Evan Brand:  Yes, it is.

Dr. Justin Marchegiani:  Awesome, buddy.  Awesome.  So anything new with you?  Any patient stories this week?

Evan Brand:  Yeah, actually I just posted a testimonial on my YouTube page or my website if people wanted to see it.  It was a patient that I saw inside of the chiropractor’s office.  One of my very, very few in-person patients that I see these days because I’m like you, a lot of people are not in the local area that need help.  So anyway, she basically eliminated her sugar cravings–I guess I would say I eliminated or maybe she just felt the effects, within 2-3 days of her supplement protocol.  So when I did the initial symptom gathering process on her, I saw that she had some blood sugar issues going on which surprise, most people do and–

Dr. Justin Marchegiani:  Right, exactly.

Evan Brand:  So I recommended some supplements that were gonna some blood sugar.  Some Aqueous Chromium and a couple different other biotics products that have some good, you know, blood sugar support nutrients in there and her testimonial was verbatim to this.  “I usually have trouble going through the candy aisle, but I went into the grocery and I felt like going straight to the vegetable section.”  I was like, “Wow!”

Dr. Justin Marchegiani:  Oh, wow!

Evan Brand:  That’s pretty cool!  So–

Dr. Justin Marchegiani:  That is awesome.

Evan Brand:  She said her stress is already better.  She had a lot going on with her husband.  He’s got some pretty bad health issues and so that stress bucket is full, but she’s already feeling a little bit calmer which has then in turn reducing her amount of emotional and stress eating that she identified with on the questionnaire.  She was one of those people that she feels stressed out, she’ll go and eat like a candy bar and now she is able to–

Dr. Justin Marchegiani:  Right.

Evan Brand:  To work through those times.

Dr. Justin Marchegiani:  Well, that’s awesome, man.

Evan Brand:  What about you?

Dr. Justin Marchegiani:  That’s a great story.  Well, I had a patient.  I’ve actually had a couple of patients in the last week where they had some severe autoimmune conditions.  This one patient I saw has an autoimmune condition called hidradenitis suppurativa.

Evan Brand:  Yup.

Dr. Justin Marchegiani:  So this is a–a really interesting autoimmune condition that like attacks the skin and creates these major boils or welts, almost to the point where they have to be, you know, surgically removed because they become so massive.  This patient had some surgery scheduled to actually get some of these hidradenitis suppurativas removed and we talked and we just did a little bit of dietary work and a little bit of adrenal work off the bat and within 1 month when she got ready to see the general surgeon to have the lesions looked at, they were gone.  And the surgeon was like, “What did you do?”  This–that happened?  The surgeon was flabbergasted and this it really comes down to a lot of the chronic conditions that medicine is seeing are autoimmune and medicine is not addressing the underlying issues of autoimmunity which is stress, which is a leaky gut, which is a lot of food-induced stuff, and there’s a lot of infections and underlying issues on top of that, and now with this patient, we didn’t even have a chance to dive deep enough into the real deeper functional medicine issues but just an autoimmune diet made a massive difference.  And this is just so cool because, you know, conventional medicine doesn’t really have a solution for this but in the functional medicine world where we live, there’s so many things we can do.

Evan Brand:  That’s awesome.  That’s a great story.  Yeah, I’ve actually had a podcast on that topic.  I can’t remember the name of the book now but there’s an author that wrote a book about that and she struggled a ton with it and it’s crazy because it’s a very underrecognized condition.  Some people at first think they have eczema and–

Dr. Justin Marchegiani:  Yeah.

Evan Brand:  These other kind of generic skin issues and then they really have an autoimmune skin issue which sounds terrifying.

Dr. Justin Marchegiani:  Oh yeah, and the cool thing about our podcast, I’m really loving our dynamic.  We’re getting a lot of great feedback on your show, on my show, and I think the podcast that we’re producing is just different than most because we’re having a lot of clinical feedback and we’re really helping people walk away with a lot of action items.  I don’t want people just to walk away feeling like they just got some brain candy and it’s like, you know, they got some stuff for jeopardy, right?  I want them to feel like they got some brain candy but they also got like an action item that they can walk away with and make their life better, performance-wise, whether it’s a biohacking thing or a clinical pearl.  Just something they can walk away with.  They can be like, “Yeah, I’m gonna–I’m gonna be better after listening to this podcast, healthier in some way.”

Evan Brand:  Right.  Yeah, I mean, I’m coming up on 150 episodes of my podcast and I’ve really felt for a while that I’m helping people but in a certain way some of these episodes that I’ve put up and I’ve even not up an episode since with some people because I feel like it was blabber and too much about them and not enough about action and things like that, and so I’m really trying to shift the show.  So hopefully, people are enjoying that on my end as well, and I’ve gotten some feedback that that verifies it and the downloads are, you know, higher than ever.  So apparently, something’s working.

Dr. Justin Marchegiani:  Yeah, and anyone listening to this and feeling like, you know what, maybe they’re at a crossroads at their health where they’re not quite sure what to do, reach out to Evan or reach out to me, and we can kind of put together an action plan on what the next step so we can move forward on to get to the underlying cause of your health issues versus just covering up symptoms which is really the only option in the conventional medical model.

Evan Brand:  Yeah, or ignoring them or saying they don’t exist like Lyme disease for example.  That’s a whole another podcast topic, but very timely.

Dr. Justin Marchegiani:  Yeah, or just numbing you out and give you an antidepressant or again, being a functional medicine doctor is stressful, too, because you get to hear all the horror stories.  I can’t tell you how many patients that come see me each week, have seen their medical provi–you know, medical provider, their GP or whatever, and they’ve been told it’s all in their head.  I just–I can’t-

Evan Brand:  Yeah.

Dr. Justin Marchegiani:  I mean, 4 or 5 times a week it makes me wanna pull my hair out because I see people suffering and we see it, they’ve come back on tests where they have functional issues and their conventional doctors are just like, “Yeah, it’s all in your head.”  And then they look at them like they’re making it up and I’m like, “Oh, my God.”  There’s a physiological and biochemical explanation, and just because it doesn’t fit into the mold of, you know, cutting it out or drugging it, it doesn’t mean it’s all in their head.

Evan Brand:  Totally.  Yeah, I’ve seen that, too.  It’s always crazy to look at the symptoms and then you look at the prescriptions they’ve taking, and it’s like, “Why?  Why Lexapro?  Why Valium?”

Dr. Justin Marchegiani:  Yeah.

Evan Brand:  Wh–why do you need this stuff?  And I know there’s a time and place for that model for some people and maybe there’s extreme scenarios but oftentimes there’s a much better alternative that happens to come from a plant or some type of botanical extract or something, so there are options out there.  I guess that’s–

Dr. Justin Marchegiani:  Yeah.

Evan Brand:  Kinda what you’re getting at.

Dr. Justin Marchegiani:  And it may be in their head from the perspective of their gut’s inflamed and inflammation in the gut creates inflammation in the brain, and there may be some brain inflammation meaning it is in their head.  But not from the perspective that the MD is meaning that they’re making it up, right?  There may be an underlying etiology and biochemical issue that is partly affecting the brain but they’re not making it up though.

Evan Brand:  Right.

Dr. Justin Marchegiani:  Cool.  Well, let’s dig in.  We chatted a little bit about amino acids and brain chemistry and mood.  I wanted to dive in deep to that because conventional medicine for the most part it’s anti-depressants, it’s anti-psychotics, it’s benzodiazepines like Xanax and such.  It’s Wellbutrin, right?  SSNRIs, things that modulate norepinephrine or dopamine or the reuptake of serotonin or increased GABA receptor site sensitivity, all these drugs they do nothing but change the location of a lot of these brain chemicals, which I might add all come from protein.  So this is powerful, right?  In the conventional medical kind of field, we have drugs that change the location of these brain compounds or these neurochemical compounds, and in functional medicine world, from just the supplement standpoint, when we give specific amino acids to alter brain chemistry we’re trying to change the amount of these brain chemicals by altering building blocks versus conventional medicine’s just changing the location, and this is a fascinating kind of comparison.  You wanna break it down a little more?

Evan Brand:  Oh, yeah.  Neurotransmitters are basically brain chemicals.  That’s the easy way to remember them and scientists–I haven’t identified per–personally any but I know they’re out there.  Scientists have identified over a hundred and they actually have no clue how many neurotransmitters there are in total.  But typically when we’re talking about helping people with health symptoms, we’re focusing on just a key group of neurotransmitters such as the GABA, the serotonin, you have the dopamine.  You have your adrenalin and then you have your noradrenalin or your epinephrine and norepinephrine, wherever you are in the world, whatever you call it.  And these basically to me, they run the show.  Hormones are equally if not more important, but to me, neurotransmitters are huge and I’ve–I mean, I just wrote an entire book.  It’s not out with the publisher yet, but I just wrote an entire book on neurotransmitters, basically talking about the way that different herbs and supplements interact with this brain chemistry and how you can tweak it towards your benefit, whether somebody listening that just wants some cognitive enhancements, some, you know, brain power, some focus ability or if you’re somebody who can’t go out of your house or go to the grocery store without having a panic attack.  There’s a wide spectrum of people that are struggling, that can get help once they first measure with lab testing and then accurately treat or align or balance those underlying brain chemical deficiencies or imbalances.

Dr. Justin Marchegiani:  Absolutely.  So the first thing we have to look at is that all of our brain chemicals for the most part are made from protein and protein is like the pearl necklace and the individual pearls are like the amino acids.  So amino acids, especially L-tyrosine which gets converted into dopamine, L-trytophan and 5-HTP which gets converted into serotonin, so these are like our master neurochemicals and they all come from protein.  So first step is making sure the diet is protein-rich, good quality, natural organic sources of protein.  That’s number one.  Number two, are we digesting these proteins, right?  Do we have enough hydrochloric acid and enzyme secretions to be able to break it down.  And then number three, if we aren’t able to break it down, what are the underlying infections, dysbiosis, SIBO, parasites, H. pylori, etc. that are creating this malabsorption?  So we kinda look at the front-end how’s the supply chain coming in?  Are we putting enough good amino acids and proteins in our mouth?  Are we breaking them brown?  Is there an infection in the gut that’s affecting that breakdown?  Once we know that front-end chain’s okay, the next is well, where are our protein levels at in our brain?  Where our amino acid level’s at in our brain and we can use symptom surveys that look at dopamine or serotonin symptoms and we can also look at organic acid tests which I think are really cool that can give us a indirect indicator of the metabolites of dopamine which is like vanillin mandelate or homovanillin mandelate or we can look at serotonin in which a good metabolite is 5-hydroxy and doloacetate.  So we can look at these from a empirical perspective, symptoms, but also from a lab perspective.

Evan Brand:  I like to do both.  For me–

Dr. Justin Marchegiani:  Yeah.

Evan Brand:  It’s really fun to look at the symptoms and see how accurate some of those symptom questionnaires can be.  I really enjoy Julia Ross’ symptom–symptom questionnaire I guess we’ll call it.  It’s amazing.  I’ll sometimes laugh at some of the symptoms I’m going through and I’ll tell Hannah, my wife, instead of saying like, “I’m feeling blue or low, I’ll just say, ‘Oh, God, I’m low on serotonin today.’”

Dr. Justin Marchegiani:  Yeah, exactly.  And again, conventional medicine, right?  Let’s kinda break it down here, alluded to it briefly.  So I’m gonna do a little demo here, you being able to see me on video, it’ll make more sense to you, I’m gonna try to describe what I’m doing.  So I’m putting my–my two knuckles together like this.  So you can see here, I have one fist on the left side connecting with the other fist on the right side, and I’m gonna leave a little gap between the fists.  So my left arm here, this is my presynaptic neuron, the little gap between my left fist and my right fist is my synapse or the synaptic cleft, and then my right fist here is my post synaptic neuron.  So again, the action potential and the neuro conductivity is happening from this left arm over this little synaptic cleft into the right arm which is my post synaptic neuron.  So I know, big talk, we’ll try to put some demos or pictures in the transcription, so head over to beyondwellnessradio.com for that.  So you’re gonna see all of the serotonin and dopamine precursors are all up here in–in this presynaptic neuron, it gets released out into this synaptic cleft and that serotonin and dopamine hangs out and it kinda helps bridge that gap from that action potential from that presynaptic neuron to that post synaptic neuron.  Now most drugs, they prevent the reuptake, so the whole idea here is these neurochemicals sit in this synaptic cleft and they get pulled back up into that presynaptic neuron and get recycled.  And what these drugs do is they prevent the reuptake of these neurochemicals so they accumulate and they sit longer in between that synapse where they could have a–a physiological effect.  Now the only problem with that is it works but in the short run it works, but in the long run it doesn’t work because all these meds are doing, they’re just changing the location of where these compounds live.  So instead of being up in that presynaptic neuron, they’re now in that synaptic cleft.  Now the problem is, these neurochemicals get recycled and broken down faster the more they’re in that synaptic cleft.  So the more, the longer you’re on these medications, you actually create more deficiencies with these brain compounds because they’re being recycled faster and that’s why anyone that’s on one of these medications, they’re gonna have the experience of having their dosage–their medication either changed to a stronger one or having an increase in the dosage.  So the whole idea of being able to come off, unless that underlying cause is fixed, typically those symptoms gets worse when you come off these meds.  So that’s why the amino acids are so different because we’re coming in and actually changing the supply, not just the location.

Evan Brand:  Incredible.  Yeah and that explains why–you know, I’ve had some people that have had prescriptions for benzo–I’ll always just call them benzos for short.

Dr. Justin Marchegiani:  Yup.

Evan Brand:  But the Xanax or–

Dr. Justin Marchegiani:  Yup.

Evan Brand:  Valium, you know, that are mostly acting on the GABA receptors, if I’m not mistaken, since those are GABA antagonists, that would be downregulating your actual production of GABA so when they try to come off, they have less GABA than they had before they even started the Xanax and now their panic attacks and their anxiety is tripled or quadrupled what it was before they even started the medicine.

Dr. Justin Marchegiani:  Absolutely, plus the underlying physiological, the underlying biochemical reasons of why they were having anxiety to begin with is just totally ignored, whether it’s excessive stimulation by the adrenals because they’re making too much catecholamines or adrenalin or because they’re gut’s on fire and they’re burning through their neurochemicals, those underlying reasons are ignored.  So the problem only gets worse and worse overtime and then they are reliant upon this constant stream of medications just to control the symptoms so they can function.

Evan Brand:  Yeah, if I go back to the lady that I was discussing at the beginning of the podcast, you know, she was having a lot of blood sugar issues, to me, you know, there’s a piece of the adrenals that are going–that are going haywire because the piece of the blood sugar is going haywire, she’s in her mid-50s right now so she has been dealing with this stuff for a long time, and she has gone to the mainstream doctor before and said, “Hey, I’m completely overwhelmed with my husband.  I’m trying to take care of him.  I’m very sick, etc., etc.,” and the only thing they had to offer her was a) either an anti-depressant or b) an anti-anxiety medicine to handle the stress.  And she said flat out and–and they can see it on the video, she said, “I don’t want the drugs,” and she wouldn’t have gotten better because the blood sugar is the issue or her stress bucket is too full and she doesn’t have enough stress bucket, so that’s kinda where I’m trying to help fix her as opposed to leading her astray.  I mean, it’s just–it’s really scary to be honest with you, how quickly some of this stuff could get derailed.  I’ve talked to you about my blood sugar stuff being–being low in the middle of the day and you’re like, “Dude, Evan, go eat, man,”  Like, “What are you doing?”  Because if I–say, I went to the doctor for some reason and said, “Hey, I’m feeling low and fatigued and maybe a little bit anxious in the middle of the day.”  They’re not gonna ask, “Are you skipping meals and you’re blood sugar is low?”  They’re gonna say, “Well, hey, let’s get you on something.”

Dr. Justin Marchegiani:  Exactly.  Exactly.  And that’s the difference between conventional medicine and functional medicine.  So the first pillar is gonna be blood sugar, right?  Because blood sugar is gonna create your–or is gonna stimulate your adrenals to make more adrenalin or more cortisol to help bring that blood sugar back up and stabilize it which can cause the jitters.  Anyone, you know, gets that feeling where they get those–the little–little Spidey senses going or they get that little tingling, that little butterflies because of stress, well, one of the biggest hormonal stressors is blood sugar imbalances.  That’s number one.  Number two, most people have chronic stress that has now affected their gut and they have malabsorption, they have infections, they have inflammation in their gut and inflammation in the gut creates inflammation in the brain.  Alright?  Now it’s important, right?  A lot of like–like people talk about serotonin in your gut, well, serotonin in your gut–serotonin can’t cross the blood brain barrier, it can’t, same with dopamine.  But the precursors, the substrates to serotonin and dopamine can, meaning the 5-HTP can cross that blood brain barrier.  The L-tyrosine can cross the blood brain.  So these are important things because when we have malabsorption and gut issues and stress, we can therapeutically use these amino acids at specific doses together.  We don’t wanna use them single at least not longer than 2 or 3 months and we can therapeutically boost up brain chemicals.  And it’s important you never wanna take these without B6 as well because B6 is an important carrier, it’s gonna escort that helps these things cross the blood brain barrier and convert into their end-stage neurochemicals.

Evan Brand:  It’d be good to go a little bit deeper on that.  You said don’t take for 2-3 months and I’ve had people that have been on 5-HTP for 2-3 years and they’re wrecked.  And I want you to explain why, because like, “Huh?  Why–why not?”

Dr. Justin Marchegiani:  Well%2


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