What Are The Strategies to Treat Fibromyalgia and The Firbo Summit | Podcast #291

Hey, guys! Here’s Dr. Justine Marchegiani and  Dr. Roger Murphree talking about things to be checked and pointed out in dealing with fibromyalgia. 

Fibromyalgia is a disorder characterized by widespread musculoskeletal pain with fatigue, sleep, memory, and mood issues. Dr. Roger shared that the frustrating thing is there are still doctors who don’t believe that it exists, and those who do, don’t understand it. 

Some issues reported by most patients with fibromyalgia include pain, lack of sleep, tired/fatigue, brain fog, restless leg syndrome, adrenal fatigue, and more.

Watch the entire podcast to learn more about this disorder and interesting approaches on how to fix it!

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover: 

0:38          Diagnosing Fibromyalgia

10:13        Approaching the Issue

20:14        Unique Treatments

25:16        Infection Pattern with Patients

32:50        Compromised Immune System  

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Dr. Justin Marchegiani: Hey there, it’s Dr. Justin Marchegiani with Dr. Rodger Murphree  here. We’re going to be chatting about fibromyalgia and the fibro summit coming your way. Dr. Roger, welcome to the podcast How we doing?

Dr. Rodger Murphree: Hey Dr. Justin, so glad to be here. Thanks for having me. This is gonna be fun.

Dr. Justin Marchegiani: Yeah, I’m really excited to be part of your summit as well. That summit will be coming out, I think on September 28. So we’ll put some links down below so you guys can get subscribed to the summit. So let’s talk about fibromyalgia. It’s kind of one of these, you know, subjective diagnoses, right? A doctor kind of comes in and you and they do these like they look for different tender spots. How does that diagnosis work?

Dr. Rodger Murphree: Well, you know, the frustrating, frustrating thing about Fibromyalgia is there’s still doctors who don’t believe it exists. There’s, there’s still some out there, have that mindset and those that do don’t really understand it, they don’t really know how to treat it and then tell their patients to learn to live with it and the diagnosis is one of elimination. So there’s no really definitive Lead test after that will show you right. And it typically takes you know, three or four years and half a dozen to a dozen doctors before you finally get the diagnosis. And you’re right it typically is a you know, it’s a hands on type of examination but but after they’ve done all the the other workup to rule out, you know rheumatoid arthritis or any type of autoimmune disease or Ms. And then eventually you get the, you know, the diagnosis of fibromyalgia and you kind of stuck with that because it’s kind of a good thing and a bad thing. I mean, it’s good to finally get a diagnosis. But once you do get that diagnosis, it follows you forever. And a lot of times it didn’t serve you very well.

Dr. Justin Marchegiani: Yeah, totally. So you go online and you look you can you can get a an image of all the different kind of tender pain spots that they’ll they’ll kind of rub gently and they’re kind of looking for this central allodynia this pain that’s, that’s it’s, it’s not proportional to the amount of physical stimulus stimulus you’re putting in when you’re touching these different spots, whether it’s the shoulder, collarbone, neck arm, just kind of the different joint. So the doctors coming in, they’re going to be running maybe, AMA, HLAB 27, all of these kind of autoimmune markers. If none of them come back, then they’re going to that physical examination. And if there’s pain in those spots at all right, then then that’s kind of the diagnosis, but it’s not really helpful outside of the fact that you know, you got it, but we got this kind of path in the road, we have functional medicine, and we have all of these biologics and pain meds. So what happens next?

Dr. Rodger Murphree: Well, you know, the thing is, once you get the diagnosis, oftentimes, I think people have a sigh of relief, because they, they think, oh, at least you know, I’m not crazy because a lot of times, they’re made to feel they they’re lazy, crazy or just a hypochondriac. And nothing can be further from the truth. I mean, nobody would want to make this kind of stuff up that you can’t sleep. You know, he had this diffuse, sometimes disabling pain, no energistics, exhausted, irritable bowel, restless leg syndrome, low moods, anxiety. You know, nobody wants to Make that kind of stuff up but totally the diagnosis then unfortunately what happens is you get past from more you know another doctor you know, you get you get on this medical merry go round. And every doctor you come in contact with, if you mentioned any symptom, any condition, they’re going to try to sweep your fibromyalgia symptoms underneath the Fibromyalgia rug and tell you Oh, yeah, the, you know, the, the stomach pain that you have. That’s fibromyalgia. Oh, yeah, the, you know, the thrush the chip on your tongue. Oh my gosh, there it is the migraines and you know, all these all these are warning signs or symptoms and symptoms or just telling you, you know, telling us that there’s something under underlying this symptom that is, you know, where’s the we need to be looking for the causes, and not treating the symptoms, but unfortunately, once you get that diagnosis, really most doctors just happy to change and learn to live with it, they’re not going to keep looking for the underlying causes.

Dr. Justin Marchegiani: Yeah, I tell my patients this all the time, like most of the time conventional medicine, I, they’re looking at the downstream symptoms, and typically a diagnosis is a bunch of symptoms that are in an organized fashion, right with a lot of the central allodynia pain, right? That’s your fibromyalgia, if it’s if it’s autoimmune type of pain, where there’s autoimmune markers, maybe that’s rheumatoid arthritis. So you’re just looking for these different symptoms and in these different pattern and once you have those symptoms, they give you an ICD 10 code and then from there, they can prescribe your drug. Now, Fibromyalgia tends to come together a lot of times with chronic fatigue so you get people that are sore, and also tired. Now, we know in functional medicine, that there may be other kind of root causes upstream like with the gut or with the hormones or the adrenals or the thyroid, what are like just the top three like root cause patterns that are upstream that you see are driving a lot of the fibro symptoms downstream.

Dr. Rodger Murphree: Well the main thing Justin is there at this allodynia, which is this low pain threshold, right? For them, their pain is magnified and you and I can go, you know, we can go get a massage, we can shake cans, we can, you know, hug our partners, we can do things that you know wouldn’t bother us at all but the fibromyalgia patient any that stimulation, which could send them over the top that so pain is magnified? Yes. But that pain is coming from it can be from wear and tear osteoarthritis or osteoporosis, bone loss, it can be from scar tissue. Past surgeries, it can be from nerve damage, it can be from elevated blood sugar issues, but they have central sensitivity pain syndrome, which means their nervous system is over ramped up, and pain is magnified. And the place to start with these individuals is you’ve got to raise the pain threshold and the best place to do That is making sure that they have plenty of serotonin. So brain hormones, you know you’re familiar with your serotonin level, the higher your pain threshold, and the higher your serotonin level, the less anxious you’re less depress your more mental clarity app. And less likely you have are to have IBS because you have more serotonin receptors in your intestinal tract than you do in your brain. So the place to start for these individuals is number one making sure that they have plenty of serotonin because anybody that has true true fibromyalgia, they’re going to be deficient in serotonin and that’s one of the main driving factors of the underlying symptoms that they have.

Dr. Justin Marchegiani: That’s interesting because serotonin we know comes from the amino acid tryptophan right? So I find common thread is going to be poor digestion, in a lot of these fibro patients. So poor digestion, maybe low stomach acid, low enzyme, maybe their diets poor, maybe They’re not eating enough protein, maybe they kind of were on a vegan vegetarian kick. Maybe there’s a gut infection that’s impeding digestion as well. How much do you see digestion? Being an impediment as well as maybe digestive infections too?

Dr. Rodger Murphree: Well, it’s certainly a big part of it, for sure. And in the Fibromyalgia community, what we see is that genetically some of them at our disadvantage, just the way God made them. Yeah. Convert trip to fan into five, proxy trip to fan they have a block and they’re kind of around kind of an enzyme pathway. Yeah. And because that conversion is not made, they’re at a disadvantage. So they’re, they’re low and seratonin. Certainly, you know, you

Dr. Justin Marchegiani: B6 playing a big role in that too?

Dr. Rodger Murphree: Yeah, so the cofactors as you bring up, you know, to make seratonin you need tryptophane, which turns into hydroxytryptophan, the B vitamins in particular B2 B3, and then any vitamin C and magnesium that’s what Yes, you know, No one has an antidepressant deficiency, you know, yeah. But you could have a five HTP deficiency or B vitamin deficiency and yes, you probably have a magnesium deficiency, if you have fibromyalgia, but the place to start for these individuals is making sure we get that serotonin level up. And when we do that, we see their pain threshold goes up. Absolutely.

Dr. Justin Marchegiani: Yeah, I see that a lot. I run a lot of organic acid tests, and I’ll look at five hydroxy and dolo acetate, and usually that’s very high or very low. So there’s usually a burning or a total depletion issue there. And I’ve never seen a fibro patient with really good digestion. There’s always some bloating, some gas and cebo or a gut infection. I almost always see that. Now what’s your take on beta endorphin? Because beta endorphin is kind of our natural opiate, and it’s made from 19 amino acids. So I mean, obviously, we see this amino acid kind of trend there any feedback on beta endorphin?

Dr. Rodger Murphree: Yeah, one of the things that you don’t have a patient’s do they fill out in the new patient questionnaire, they’ll have a brain function questionnaire, little survey and it across the board, it shows that they’re low in serotonin, but then they may be deficient in dopamine and opioids and some of these other things that show that they have other amino acid deficiencies besides five HTP. Bingo. No, no. So it definitely shows up. That’s a pattern that we see that they’ve Yes, deficient in these amino acids for, you know, whether it’s genetics, or you know, poor diet, or there’s something that’s compromising their ability to be able to absorb these nutrients like SIBO, or leaky gut or some type of bacterial overgrowth.

Dr. Justin Marchegiani: Yeah so my strategy, I’m curious to get your so my strategy is I try to figure out a way to get the sympathetic nervous system in check, because most of the time, the adrenals is that kind of gateway between, you know, the sympathetic nervous system. It’s kind of how that when you interpret stress, you’re making adrenaline, you’re making cortisol and when you have that level of stress, you’re going to be burning up a lot of those neurotransmitters. So I try to get the adrenals under control, and then I’ll I work on supporting more of those amino acids, more of those cofactors. I try to get tests so I can get specific. What is the root issue? And I’m just curious to know your take on that. How did what’s your kind of out of the gates approach?

Dr. Rodger Murphree: Well, there’s for me from doing this for 20 years, found there’s four key things that have to really be addressed. Because if you got 15 tax in your foot, and two or three tax, you’re not going to notice a difference. And that’s-

Dr. Justin Marchegiani: A great analogy. Excellent analogy.

Dr. Rodger Murphree: You know, what they’re doing is they’re taking resveratrol, or, you know, they’re taking coq10 or tumeric and those things, those are great. But if you don’t pull out a bunch of tacks real quick, you’re never going to see a difference. So totally. It’s the analogy that we’re all born with a stress coping savings account. And in that stress coping savings account, we have certain chemicals that allows us to be able to deal with stress. So we have serotonin, dopamine, norepinephrine, cortisol, DAGA, Panasonic acid, cortisol, these things Are there and anytime we get under stress, we’re using these chemicals to deal with stress. But those who have fibromyalgia, they haven’t bankrupted their stress coping savings account. So they have this deficit. And then when they, you know, get up to face the day, they’re already done, you know, they just don’t have those chemicals they need. So the first thing that’s gonna happen is we got to replenish that stress coping Satan’s count. And that is done by deep, restorative Delta wave sleep. So if they’re not getting a good night’s sleep on a consistent basis, they’re going to have many of the symptoms that we you know that we associate fiber Imagine if you’re not getting deep restorative sleep, your inflammatory chemicals are increased by 40%. They’re going to have more pain. If they’re not getting deeper short asleep, their pain threshold goes down so pains magnified. They’re going to obviously going to be tired gonna have fatigue, brain fog, which is a common symptom of these individuals. Eero bow, you have more as I mentioned, more serotonin receptors. In your test or trial, you’re doing your brain. restless leg syndrome starts to show up. Once they can get a consistent deep restorative sleep, then they’re going to see that many of those tacks we can start to pull those out. So the first place to start is deep restorative sleep, making sure they’re getting plenty of serotonin. And then the next place is, as you already mentioned, is the adrenal fatigue. But because they get a good night’s sleep, and they start to feel better, then even though they’re cautioned not to do that, do this, you know, in my book, they’ll go out and do things hadn’t been able to do in years, and then they’ll have a fibro flare and they’ll be back in bed because they don’t have the stamina, or resiliency to stress, physical stress, mental stress, real or imagined. And so if they don’t fix their stress coping glands, the adrenal guess, be vulnerable. The third thing is in your already mentioned up mentioned this astutely. You, you’ve got to fix any kind of gi issues. Yeah, amongst with digestion or problems or elimination, you know, problems absorbing in every fibromyalgia patient I’ve ever worked with last 20 years. There’s something there whether that’s SIBO leaky gut, yeast overgrowth, parasites are just reflux and malabsorption. They’re not absorbing, they’re huge. That’s that’s got to be fixed. The last thing, which really could easily be the first thing, it’s you’ve got to lay the foundation with high doses, but the right combination of vitamins, minerals, amino acid and central fatty acids, because if you don’t have these building blocks, you can’t make these hormones and chemicals that they need to write themselves. In. Now, most people have tried a multivitamin. They tried this, they tried that. But what they’ve taken is, is so inferior to what they need, they’re they’re looking And things like, a Centrum silver or one a day.

Dr. Justin Marchegiani: Oh, yeah.

Dr. Rodger Murphree: Which is you know, based on the RTA the recommended disease allowance, right? Yeah, it’s just enough to get, you know, keep you from getting scurvy, or berry berry, it’s not gonna, you know, provide optimal nutrients that you need to be healthy is, you know, so So it’s this, this four pillars that I think are just crucial you got to get those. And then, you know really once you do that you’ve pulled out a lot of tax, you may be pulled out 10 or 12 tax. Now there’s three texts that are still left, and they’re still giving you trouble. But at least you’ve made this dramatic impact. And then you’ve got to go look for what are some of the underlying other underlying conditions that may be driving the symptoms like, you know, problem with their thyroid?

Dr. Justin Marchegiani: Yeah, it’s really interesting because not all the tax create the same amount of pain. So sometimes it’s the eight tax you pull that out, so Whoa, a really big improvement and sometimes you pull them out. And then the improvements delayed like it’s like, oh, I’m starting to see a five or 10% improvement one to two months later. So it’s interesting. Where the compliance factor like really getting the patient’s mindset on board is is crucial because it’s never going to be a meet every now and then that you get a miracle tax. Sometimes it’s too late. So you got to paint that big picture and compliance is big. And when you talk about some of the nutrients, you do have a really good multivitamin that you formulate or what what should people be looking in their multis at certain doses at certain the quality of the nutrients? What should they be looking for, Dr. Roger?

Dr. Rodger Murphree: Yeah, so years ago, when I start treating Fibromyalgia we had I had a medical clinic where we had five medical doctors work for me. And we did high doses of IV therapy. So we did Myers cocktails back then. Yeah. And we found by doing that, Justin that if we gave them these vitamins and minerals, that they slept better, they had less pain, he had more energy, they had better mental clarity. They just felt better. But it wasn’t practical for people every day couldn’t do it hooked up to an IV. Yes, years ago, I developed this thing called the CFS fibro pack, which has high doses of vitamins, minerals, amino acids and essential fatty acids in there and some other things like malic acid, magnesium, potassium sparks a to help drop the cellular energy, it but you can find something, you know, similar for you but, but that is the cornerstone of what my patients take. They take that, as well as some other supplements like a good digestive enzyme, an over the counter adrenal cortex, supplement and then the five HTP that makes up this thing called the jumpstart protocols, that people who read my book, they’re encouraged to try that on their own and get as far as they can before they reach out to me to set up a phone console.

Dr. Justin Marchegiani: Interesting. And you mentioned the serotonin which you mentioned lowers that pain threshold which is which is really important. But we know serotonin also is that precursor to melatonin. Which helps to sleep and you mentioned the Delta wave in the sleep. So it’s kind of like, everything’s kind of connected. It’s not just like, one web, it’s like you hit one web, it moves the whole spiderweb. So you Okay, you you increase the pain threshold, and then you help the sleep. And then the sleep helps the adrenals and the adrenals help the inflammation, and it just keeps on spiraling.

Dr. Rodger Murphree: Yeah, it’s all connected. You know, it’s a myriad connections there. Yeah, the five HTP increases your natural sleep hormone melatonin by 200%. So that was when I started doing the research on that. Well, it’s been two decades ago, and found that correlation, it was a no brainer to start putting my patients on that. And then thankfully, along with making the serotonin, it really encourages them to be able to wind down and be able to get a good night’s sleep. Now there’s some other things typically have to add to that sometimes adding some additional melatonin to the five HTP. But the five HTP has been extremely helpful for these folks.

Dr. Justin Marchegiani: And if you’re not getting I mean, if you’re not getting the optimal results regarding sleep, I mean, imagine you may keep the five there to help with the serotonin so the pain improves but Wendy added melatonin to the mix. When does that happen?

Dr. Rodger Murphree: Bite promote sleep protocol it’s they start off with 100 milligrams of five HTP 30 minutes for bed with a little bit of grape juice doesn’t take much, but the grape juice is going to cause the body to release insulin to help pull that serotonin pass the blood brain barrier. Yeah, going to the stomach just a little trick. And then if they don’t fall asleep within 30 minutes, then that in sleep through the night, the next night they go to 200 milligrams and then they need to they get a 300 milligrams, but they get up to 300 milligrams and they’re still not falling asleep or they’re not staying asleep. That’s when I would start adding the melatonin preferably sublingual melatonin somewhere, you know three milligrams or so and they and they can increase that up each night up to about 12 milligrams and, and then hopefully that does the trick. If it doesn’t. Then I would add things like gamma means butyric acid GABA. So I have a little sleep form that I put together that it’s combination of GABA and l theanine, ashwagandha and delirium, and passion, passion flower, that can be taken to really calms them down before bed. But it’s even more useful for those individuals who wake up at, you know, two, three o’clock in the morning can’t go back to sleep, they can take this product called Delta sleep, or something similar. And it allow them to fall back to sleep within, you know, 10 minutes or so, and it doesn’t make them feel hungover, dopey or sleepy The next day, like some of the prescription medications would.

Dr. Justin Marchegiani: Tat’s great. I think we’re just really dropping a lot of key clinical pearls here. So if you’re a patient and you’re have these kind of issues, try to glom on to one or two of these things. I think it’s really important especially if you’re in that Fibromyalgia camp, you really want to work with the practitioner because there’s a lot of as Dr. Roger gave the example of tax you got to pull out and these are a couple of one or two key tax, but there’s always a Plan B a Plan C a plan D, it always seems easy when everything works with Plan A the first time around, but I think Dr. Roger will probably agree a lot of times you have to dig deep into that tool basket with a lot of other plans too. Would you agree?

Dr. Rodger Murphree: Oh, absolutely. But I think you’ve got to lay the foundation for what, what trips people up with fibromyalgia and those trying to treat Fibromyalgia is they try to put the cart in front of the horse, you know, is you know, there’s such a unique individual. And a lot of times they may go to an integrative doctor or maybe a function doctor. And, and he or she will, okay, let’s put you on biomechanical hormone replacement therapy because that’s, you know, as a female, it’s, you know, that’s a lot of times what they do, but that may not work and usually does it you to me, these four steps that I just mentioned, that 

Dr. Justin Marchegiani: Do you mind if we repeat the steps one more time, what they are?

Dr. Rodger Murphree: Deeper store to sleep. You got to replenish your stress coping stages account. And the way you do that you you make deposits into your stress coping savings account by going into deep store to sleep. So you’ve got your peritonei level up. So five HTP and then the second one is you got to fix adrenal fatigue every everybody as far as adrenal fatigue, so I use adrenal cortex glandulars for my patients. And then number three was digestive issues. I put everybody on digestive enzyme and then if they need other treatments for cebo, leaky gut or things we’ll deal with that. And then the last one was a good high dose, multivitamin mineral formula with essential fatty acids Fishel, malic acid, extra magnesium, which is so important, but those four things provide the foundation really to build upon it really, you know what it does? It’s, if you kind of think of you know, if you got this complicated jigsaw puzzle. And you just throw all the pieces out on the table. And until you get the corner of the puzzle, right? You’re, you could just be looking forever to put the pieces together. But once you get the corner, now everything starts to come together, you can build that puzzle. So the first four things, make up one core in a corner, I’m sorry. And then the puzzle starts to come together. But you may have to, you know, find another piece of the puzzle that’s, that’s eluding you could be a problem in your thyroid. Could be a problem with yeast overgrowth could be a problem of food allergies. But if you don’t get that first corner, boy, you’re going to struggle, you’re really going to struggle.

Dr. Justin Marchegiani: Totally agree that makes a lot of sense. Now, when you’re working with patients, are you testing their adrenals? And it sounds like you’re finding a lot of low cortisol in your patients. Is that true?

Dr. Rodger Murphree: Yeah. So I think you know, we These individuals are very complicated ideally, although I do have programs where they can try to do it themselves to talk about that in the book. Ideally you want to test I mean, you’re not trained in functional medicine. You know, you don’t want to guess you really want to try to laser in find out where the key linchpins for helping these folks and you want to know what’s going on. So yeah, when I’m when I’m doing a four sample saliva test for their adrenals, I see it’s all over the place. So it’s low. In the morning, it’s bottomed out and sky high first thing, you know, because they’re not yet now drive that, that level up. But it’s about really balancing that out because it’s, you know, very well, a lot of times we’ll see that there. DAGA is it then of course, our levels, okay. But their DAGA is really high. And that’s a sign that the body’s trying to hang on. Yeah, but it was going to bottom out right. Or they’re gay is bottomed out and of course, all levels are bottomed out. So you had treat both of those, or you may find, like I do a lot of patients is that they have a low cortisol in the morning. And then as the day goes on, you know, it should, it should keep going lower. But for, for these individuals, their cortisol level actually spikes towards bedtime. So there’s like they’re catching their second window.

Dr. Justin Marchegiani: And they just rhythm almost.

Dr. Rodger Murphree: All day they’re exhausted. And then about nine o’clock they catch the second wind and like, Oh, well, I haven’t been able to do anything all day. Let me go clean up the kitchen or straighten up or you know, wherever it is, and then they miss the window of opportunity to get in bed on time and now they’re, you know, they really just continue to throw their sleep wake cycle into further Helter Skelter.

Dr. Justin Marchegiani: That makes sense. Do you test any of the total cortisol? Do you do any of the urinary cortisol as well to get a window into free as well as total?

Dr. Rodger Murphree: I don’t. I don’t do that and find it. I guess. Probably just from doing this for so long, I know that the majority, I would say when I say the majority, I mean 98% of them are gonna have a problem with their adrenals. And if I can just make sure what the pattern is, then I can on the right supplements that will you know, that will correct that.

Dr. Justin Marchegiani: Yeah, that makes a lot of sense. What also do you see in regards to an infection pattern like pate with patients? I’m seeing h pylori blastocyst is hominis. Sometimes you see things like epstein barr, maybe even a Lyme issue, what kind of infections Do you see? And it sounds like you kind of have that priority. You hit those four pillars that you mentioned. Right? adrenals and, and the nutrients and the sleep and etc. And then you kind of do dive into infections later, is that part of when you’re addressing the gut stuff? Where do the infections come in? And what are the top maybe three or five infections that you see that play a role with fibromyalgia?

Dr. Rodger Murphree: Probably the most consistent one is yeast overgrowth. So I test everybody for yeast overgrowth, test, everybody for parasites. blastocyst is hominis definitely shows SIBO is definitely a thing that is for whatever reason, you know, I think you kind of run into these patterns where you you know you get one and you get two then you get you know dozens I’m at a time. Mold issues certainly starting to show up. But definitely infections are there. I’m really careful not to go after them. Initially, certainly not aggressively because we Fibromyalgia they, they they can’t handle the stress they bankrupted their stress coping chemicals, and they bankrupted their stress coping gland. So stress is magnified. I don’t want to get aggressive on treating yeast or SIBO or some of these things that show up until I get them going into deeper storage of sleep. Start working on their dreams and then yeah, absolutely. Then you have to look at you know, definitely h pylori shows up as well. You have to start dealing with those because that’s something that’s going to be leftover that’s going to create, if it’s, you know, if it’s if it’s leaky, God is you know, that’s going to create More information and more pains. Yes, with at some point.

Dr. Justin Marchegiani: I just really wanted to highlight that for the listeners because this is probably the biggest mistake I see with a lot of my patients and people that I connect with online is we just live in this generation that’s antibiotic driven. Oh, you have an infection, staph strep STD, here’s an antibiotic knock it out. And that can be stressful on the body. Number one, it wipes out the microbiome which affects the immune system, gut permeability, but it’s stressful going after an infection. And when you don’t have the reserves, your sleeps already amassed, you’re nutritionally deficient, you can’t digest that’s like a big stress ball on that bucket or another five tacks underneath that foot. So I’m really glad that you highlighted that.

Dr. Rodger Murphree: Yeah, you know, and I think that’s the thing is what you want to do with fibromyalgia you want to try to find and fix the underlying causes, because really, you know, Fibromyalgia is just a name. It’s all it is, is a name given to a group of symptoms that people have in common, and we call it fibromyalgia. And so if you can start to find and fix each underlying cause Eventually you’re going to get your life back and that may take you know, that may take different things but certainly the God is you know, that’s number four you have to you know, you have to fix that.

Dr. Justin Marchegiani: Totally. And you mentioned a couple of different things and I know the protocols are going to be specific to each individual person and where they’re at. I get that so people that are listening, I want you to just talk about do you have like a couple of your favorite herbs on the gut side and also do you have a couple of your favorite herbs on the virus side and how much do viruses play a role in this whole thing?

Dr. Rodger Murphree: You know, as far as I don’t use a lot of herbals I do use some but I don’t use it. He is some may think think that that in the fiber match community. A lot of them have chemical sensitivities have issues. A careful what you what you do in the having said that I also really recommend everybody a food allergy test because food allergies, right masqueraders but for digestion, the first thing I do is put them on digestive enzymes or on the team You know, make sure that we we start from the beginning, you know, make sure they’re digesting their food. 

Dr. Justin Marchegiani: That’s key. Yeah. 

Dr. Rodger Murphree: If they have issues with with yeast overgrowth, or even SIBO then I’ll turn to things like bio seed, which has oregano, and berberine and some of these golden still herbals in their-

Dr. Justin Marchegiani: Black walnut, ekinesia. Yep.

Dr. Rodger Murphree: But I don’t use a tremendous amount of herbals, just for the fact that I really find that using the right doses of vitamins and minerals, essential fatty acids and amino acids typically start to turn these individuals around, you know, but but definitely there is a place for for berberine and undecylenic acid and caprylic acid. I mean, there’s definitely those can be incredibly helpful for these folks.

Dr. Justin Marchegiani: How about the virus stuff? Do you use any natural antiviral supports, and what viruses Do you see in And what are your like top three on the anti viral side?

Dr. Rodger Murphree: You know, it’s interesting that I don’t see a lot of viruses, which really surprises people when I say that I used to more so than I do now, let me let me explain why that is. You know, people think of fibromyalgia is being driven by a virus, and they can’t have viruses. But if you look at you know, Fibromyalgia is on one end of this clothesline, and chronic fatigue syndrome is on the other end of the clothesline and sometimes they get lumped together and you can have both, but if you look at true fibromyalgia and true chronic fatigue syndrome, with true fibromyalgia, their symptoms are number one pain, right, but they can’t sleep and they have no energy and, and then if you look at the true chronic fatigue syndrome, they can have trouble with their sleep and they do have achy flu like pain. And obviously the number one symptom is no energy, so fatigue, but the difference between the two is that those are Fibromyalgia don’t necessarily have anything wrong with your immune system. Those with chronic fatigue syndrome all have some type of immune dynamic, something that is, you know that is compromised that so that they’re always fighting off some type of infection. And absolutely in those individuals, you got to go after that, find out what that is and use things like lacto Fearon, or using thymus extract some of these things in Oilers system that can be incredibly, incredibly beta one, three glucan some of these things that I use for these individual, but you know, it’s odd because over the years, for whatever reason, I have attracted less chronic fatigue syndrome patients in the last probably 10 years, than I have fibro to me fibro, and I hate to be careful how I say this. Yeah, Ramalgyia is I won’t say it’s easy but for me it’s it’s there’s a system that seems to work chronic takes syndrome. Once you start working with that, if you’re not careful, you open up Pandora’s box and you find that not only is it viruses, but then you also have parasites and you have Lyme and many things that you mentioned, that tends to be more down on this end of the clothesline with property syndrome, than it does fibro.

Dr. Justin Marchegiani: And you’re differentiating that between the fact your fibro have the central allodynia that’s just the wound up nervous system the pain spots at the joints and throughout the body, but they don’t really have the energy problems or energy still pretty good is that the differentiating factor?

Dr. Rodger Murphree: Know the difference because we’ve thought about them and they have many of the same symptoms as those with chronic fatigue syndrome. Yeah, separates and you can be anywhere along the clothesline, you know, but what separates the two is that those with chronic fatigue syndrome always have a compromised immune system. 

Dr. Justin Marchegiani: And your by your saying compromised immune system, so they the fibro patients still might have fatigue, but you’re just not seeing what a diagnosed autoimmune condition along with fibro or they get sick a lot. How are you defining compromised immune system?

Dr. Rodger Murphree: So for those who have fibromyalgia, they, they normally don’t have problems with random sore throats. They don’t have swollen lymph glands. If we test them, they don’t show antibodies to epstein barr virus, or cytomegalovirus kraftig syndrome, you’re going to see elevated epstein barr virus cytomegalovirus herpes viruses, they’re going to get random sore throats out of the blue. They’re going to have palpable lymph nodes, you know, they’re gonna be swollen glands. Oftentimes, they have issues with laryngitis, they just lose their voice for days at a time because they get so exhausted. With fibro, you can have some of that. But that’s not the norm in kraftig syndrome. That’s the norm.

Dr. Justin Marchegiani: So I’m just trying to wrap my head around this because the diagnoses are kind of a little bit flaky. So if these fibro patients still have they’re still really tired, right? What’s the conventional different like, if you’re a conventional Medical Doctor, what makes you diagnose this person with chronic fatigue with the immune stuff, but these people over here without the immune stuff, they’re still tired. What what allows them to get that chronic fatigue diagnosis on the conventional side?

Dr. Rodger Murphree: I think typically it comes down to the doctor that they see. So that’s more familiar with complex syndrome, they’re probably going to get that diagnosis than they would fibro. If you said doctor this more for me with fibromyalgia, they’re going to get that diagnosis. And right now you got even though there’s not a lot, you probably got more doctors who are familiar at least with fibromyalgia, they don’t really know how to treat it. Then they have conflict syndrome that that illness, chronic fatigue syndrome is something that most doctors really don’t know anything about.

Dr. Justin Marchegiani: And there’s another name for for fibromyalgia over in Europe, right it’s the mycologia with it with the name Britain Europe.

Dr. Rodger Murphree: Yeah, what now for [inaudible] syndrome is myalgic encephalitis so with us.

Dr. Justin Marchegiani: Yeah, okay. And so it sounds like to me it’s not necessarily the diagnosis that matters it’s more the immune symptoms of antibodies to these different viruses and then that chronic immune reaction lymph nodes chronically sick is that is that kind of if we kind of really boil it down is that more specific you think?

Dr. Rodger Murphree: Yeah, but I think we got to be careful because I think there’s a misconception that Fibromyalgia is an autoimmune disease ever seen that in any in you know, we’ve been looking for the smoking gun, it’s not there. So I don’t believe Fibromyalgia autoimmune disease. We don’t know if chronic fatigue syndrome is it probably could have an autoimmune component to it. We haven’t found that yet either.

Dr. Justin Marchegiani: So a lot of thyroid autoimmune people that have fiber though?

Dr. Rodger Murphree: Now that I was gonna say is see a ton of autoimmune hashimotos thyroiditis. So with in the patients that I work with F5 about 70% of them have something wrong with their thyroid. Many of those have Hashimotos many, many of those with hashimotos have never been properly diagnosed. So they have the, you know, the festering symptoms they had for 5-10 years. No one’s ever checked their antibodies or thyroid antibodies. So that they never knew they had it. But yeah, definitely that, but you know, I don’t see. I don’t see lupus. I don’t see rheumatoid. I don’t see sjogrens I don’t, it’s there. It can be, you know, could be could be a companion to the Fibromyalgia but it’s not what’s driving the fibromyalgia.

Dr. Justin Marchegiani: Yeah, cuz I see did you see patients though with a lot of the hashimotos and the fibro and of course I do find that like gluten. Cutting gluten out really helps a lot of the the pain symptoms and I know gluten plays a big role of gut permeability. So even though the research may not show that I have a sneaking suspicion there has to be something underneath the hood, or we wouldn’t see a lot of these connections. When you address them, they improve prove a lot of those fibro symptoms.

Dr. Rodger Murphree: Yeah, you know, and you know, that’s one of the big conundrums for fibromyalgia. I think there’s just so many things that are wrong.

Dr. Justin Marchegiani: Yes, the hard part. 

Dr. Rodger Murphree: Can write itself the way that you and I were trained in chiropractic school that innate intelligence. You know, we’re born with this incredibly inborn healing Dynamo system, that normally we don’t have to think about taking 12 breaths per minute or pumping blood to 60 miles of arteries and veins, we just write these things. But with fibromyalgia, those systems get get compromised the hypothalamus, the pituitary adrenal HPA axis, when it gets under too much stress, it can’t regulate these different systems. And now because of that, you see, so many symptoms start to show up, because so many systems are not working like they’re supposed to. And that’s incredibly challenging for the doctor that wants to try to try fibromyalgia, most most work because it’s too complicated. And it’s incredibly challenging for the patient. Because where do you start?

Dr. Justin Marchegiani: No, I totally agree. And you’ve done a great job during the podcast just to kind of outline a couple of the really good pillars. Obviously we have the fibroid, the fibro summit coming up in the next two weeks on the 28th. So really excited. We’re gonna put the links down below as well. I see a book on the shelf back there. Is that your book? Would you mind put it on screen?

Dr. Rodger Murphree: Yeah. So this is my Treating and Beating Fibromyalgia and Chronic Fatigue Syndrome book. It’s in his fifth edition, the sixth now? I didn’t November so yeah, labor of love. You know, for the last 20 years, you know, it’s been my mission to help those with fibromyalgia, learn how to live healthier, happier, more productive lives because you know what they’re being told right now Justin is just learning to live with it. But you know, I want to learn to live with chronic pain, no energy, brain fog, insomnia, restless leg syndrome, irritable bowel mean. That’s it. That’s not living that’s existing. So, you know, the fibro summit is an opportunity for individuals with fibromyalgia, to get a breath of fresh air, sort of set off all the doom and gloom out there. They actually can learn from people like yourself, she did a fantastic interview, all about thyroid, we did a deep dive into this interview. So people like yourself are sharing incredible information, that if you have fibro or even if you just want to be healthier, there’s so much we share in the summit, about mold and parasites and adrenal fatigue and insomnia and leaky gut and gluten intolerance and food allergies, huge. If you’ve just can’t get a few little key things from these interviews. It may be the missing piece of the puzzle that you need to put it all together and get your life back.

Dr. Justin Marchegiani: I mean, that’s awesome. Now, if patients want to get a hold of you, they’re like, great, I’m going to get the book. I’m going to get the summit. I’m going to start applying some of this stuff, but I want to work with you. How did patients work with you?

Dr. Rodger Murphree: Yeah. So appreciate that. They can go to yourfibrodoctor.com and there’s free videos in there, blogs, free protocol and a tremendous amount of free information so I encourage you to check out, see if it resonates with you. If it does, you’re on the right track.

Dr. Justin Marchegiani: That’s great. We’ll put the links down below for the book, for the summit, for Dr. Roger’s website. Dr Roger, anything else you want to leave the listeners with?  Do you have a youtube channel or a podcast? Anything else people can get more info about you?

Dr. Rodger Murphree: Yeah so we do have a youtube channel and you’ll see that on the website, a blog, both of those podcasts coming soon. And you’re going to be one of my first guests by the way. We’ll be coming soon and I just want to say thank you. I want to thank you for for everything that you do because the information you’re sharing is so needed and without people like yourself taking the time, making the time because I know you’re busy just like I am and you’re dedicated to getting the the message out there, that you you know that you don’t want to be just treating symptoms. You really want to be finding and fixing these underlying causes whether you have fibromyalgia or you have migraine headaches or type 2 diabetes and your podcast which I’ve been checking out here recently is just fantastic. So thanks for what you do.

Dr. Justin Marchegiani: Thank you so much Dr Roger. Really appreciate it. And people listen to so much information here especially if you’re coming at this with fibro or chronic fatigue, it’s hard to grab a lot of these things. So just rewind it, listen to it again, try to grab one thing that Dr Roger said. Try to get the book, get access to the information and make sure you get on that summit. Amazing great speakers there. Dr Roger thank you so much for being a part of today’s podcast.

Dr. Rodger Murphree: Thank you Justin so appreciate it.

Dr. Justin Marchegiani: Thank you.


References:

https://justinhealth.com/

Audio Podcast:

Nutrition is Science-Backed Medicine

By Dr. Justin Marchegiani

Nutrient: “a substance that provides nourishment

essential for growth and the maintenance of life.”

You Are What You Eat

Why do people change their diet? While popular answers are to lose weight (fat), or to get in better shape (adding muscle), good nutrition is in fact about so much more than changing your physical appearance. Proper nutrition–diet and supplementation–is a science-backed way to improve your health. “You are what you eat,” and everyday you have the power to decide how the foods you consume will serve you. Let food be thy medicine: heal your gut, balance your hormones, improve your mood, boost your energy, and more.

Nutrition as Medicine

As kids, many of us were told to eat our vegetables–why? ”Because they’re good for you.”

As adults, we are told to eat our vegetables–why? “To shed some weight.”

Neither of these answers demonstrates the true healing nature of what we put in our bodies, so, without further ado, here are some of the most powerful science-backed healing properties of a healthy diet!

Click here for a personalized health plan from a functional medicine doctor!

Physical Appearance

We all know that changing our diet can help us lose weight, but did you know that a healthy diet can improve the appearance of your skin and hair too? B-vitamins, like biotin, have been shown to improve the appearance of skin and nails. Collagen also supports healthy hair, skin, and joints!

Increased Energy

A poor diet lacking in healthy macro and micronutrients–paired with a diet high in sugar, alcohol, and processed foods–can lead to headaches, brain fog, and fatigue. On the other hand, eating grass fed meat, healthy fats, and lots of fresh vegetables will give your body the fuel it needs to function optimally.

The Standard American Diet (“SAD” – a fitting acronym) is full of inflammatory processed foods and refined carbs & sugar which deplete the immune system, increase the rate of cancer, and increase the risk of developing autoimmune disease. 

Inflammation is the root cause of most diseases: but a diet rich in anti-inflammatory foods is the best gift you can give yourself to feel and function at your best!

Better Sleep

Poor sleep–whether you’re lacking hours, or your sleep quality is not that good– can increase your risk of diabetes, decrease your immune system, and accelerate aging. 

Alcohol and caffeine both impair sleep quality. Caffeine has a half-life of around 6 hours, so ideally you want to have your last cup by 2pm. Alcohol robs you of restorative REM sleep, which in addition to its dehydrating effects, lead to the next day’s dreaded hangover.

Food that positively affect sleep include veggies, grass-fed beef, chia seeds, sweet potato, wild-caught salmon, and those rich in magnesium. On the other hand, simple carbs and sugar negatively affect blood sugar and sleep–especially if consumed in the evening.

Balanced Hormones

Your body *needs* fat! Fat is required for your body to produce various hormones and keep inflammation low. Carbs, especially simple carbs, can actually increase inflammation and disrupt the delicate balance of your hormones.

If you suffer from leaky gut or other gut issues, you may be deficient in gut bacteria. Probiotics, like those from fermented foods–like sauerkraut, kimchi, and kombucha– provide your gut with beneficial bacteria which can help keep your hormones in balance.

Improved Mood

Did you know that dairy, sugar, and gluten are linked to depression? While the Mediterranean diet, rich in saturated fat, fish, and vegetables is associated with both decreased rates of depression *and* a longer lifespan!

Ready to Take Charge?

By now, you should have all the motivation you need to make a change for the healthier. Here are some resources to help you get started:

  • The JustInHealth Eating Plan
    • How to Eat, What to Eat, and the Healthy Meal Matrix
  • Nutrient Support
    • If you or your diet is deficient in certain nutrients, supplementing with high quality supplements shouldn’t be overlooked!
      • Iron Supreme: Hypothyroidism, anemia, and iron deficiency are all linked. Many women are iron-deficient, which can be remedied by eating red meat and supplementing with a high-quality iron supplement, like Iron Supreme.
      • Magnesium Supreme: Magnesium is essential for proper function of over 300 enzymatic reactions and for the performance of many vital physiological functions. A magnesium deficiency can lead to osteoporosis, blood sugar problems, poor sleep, muscle cramps, and more.
      • Multi-Nutrient Supreme: Your daily all-in-one for general nutrient support! Vitamins A, B, C, D, E and so much more!

Questions? Click here if you are ready for help learning how to take your health back into your own hands!

References:

https://www.ncbi.nlm.nih.gov/pubmed/24939238

Jun S Lai, Sarah Hiles, Alessandra Bisquera, Alexis J Hure, Mark McEvoy, John Attia; A systematic review and meta-analysis of dietary patterns and depression in community-dwelling adults, The American Journal of Clinical Nutrition, 2014;99(1):181–197

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5532289/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5637834/

 

Mitochondrial Nutrients on Fat Burning with Evan Brand | Podcast #206

Mitochondria are often referred to as the powerhouse of the cell. They are the tiny organelles inside cells that are involved in releasing energy from food. Their efficient function very much depends on one’s lifestyle and diet. Watch the video and learn the essential supports to these tiny friends before burning that fat on the gym!

Today’s podcast talks about ways to enhance one’s metabolism, the low-hanging fruits, how vegetarian diets miss out essential nutrients, or why carnitine deficiencies result in decreased ability to use long-chain fatty acids as metabolic fuel. Stay tuned for more and don’t forget to share. Sharing is caring!

Dr. Justin Marchegiani

In this episode, we cover:

00:15    B-Vitamins: The Low Hanging Fruit

06:07    Carnitine

11:39    Free-Form Amino Acids

14:13    Underlying Toxins that Affect Mitochondria

19:08    Functional Medicine that is Results Driven

23:25    CoQ10, Ubiquinol, and Ubiquinone

Youtube-icon

Dr. Justin Marchegiani: Hey there it’s Dr. Justin Marchegiani, welcome back to the podcast. Evan Brand, how we doing today my friend?

Evan Brand: Hey man, happy monday. We’re playing with some new technology to try to make ourselves look pretty, so let’s see how it works.

Dr. Justin Marchegiani: Yeah, you had a new camera on, here I saw my same uhm– more updated uh– HD webcam. We may update that in the future to a 4K one, we’ll see how it goes. But today we wanted to chat about how to enhance your metabolism. What nutrients we can use to enhance your metabolism. So, why don’t we dig in? So, off the bat, we have various energizing nutrients. We have the low hanging fruit which are B-Vitamins. Yeah, B– B-1 which is gonna be thymine, B-2 which is going to be riboflavin, B-3 which is niacin or niacinamide, we have B-5 which is pantothenic acid primarily used by the adrenals, or significantly used by adrenals, B-6 which is P-5-P, or Pyridoxal-5-Phosphate. B-6 is really important for activating and converting a lot of our brain chemicals, amino acids in our brain like serotonin. F– err– 5-HTP to serotonin, to tyrosine to dopamine, adrenaline etc. And we also had B-9, a.k.a. folate, or folic acid. We wanna use activated form, so either calcium folinate, or L– uhm– MTHF which is activated folate. We also have B-12, me– methylated which are gonna be better,  hydroxy adenosyl as well, we wanna avoid the cyano form. So that kind of rounds up a lot of the B-Vitamins. So, first off, the low-hanging fruit for enhancing your mitochondria, enhancing your body’s ability to burn fat, let’s just say it’s the B-Vitamins. Now from a food stand point, really high and high quality meats and– and vegetables, right? So, that’s kind of a low hanging fruits. We really wanna make sure digestion is good for digesting meats and such. And we’re eating a really good kind of a paleo template, lots of vegetables, lots of healthy meats, and we have good digestion, that’s gonna help us off the bat to really maximize our B-Vitamin digestion, absorption and assimilation.

Evan Brand: I was looking at my O-test the other day and I thought, “Dang it!”. I was actually really-really low on B-6. Even though– I guess I have been supplementing for– maybe a few months after my O-test, but I can’t remember when I started it. So I was tryin’ to do the timeline like, will my D’s burning through my B’s quickly, due to working too much, or– what is it, you know, so, we find that B-Vitamins are low all the time. We do know that stress burns ’em up, you and I talk about this all the time with like amino acid metabolism, we talked about burning through neurotransmitters quickly, so– B-Vitamins, same thing, and then Vitamin-C, I would put that in the same category too. We actually test Vitamin-C on the organic acids panel, I would say like 9 out of every 10 people we test are low on Vitamin-C. I actually drink some this morning. I just do a mixed ascorbate powder, with the citrus bioflavonoids, and 25 hundred milligrams all you need in 2 months and you can rebuild your levels.

Dr. Justin Marchegiani: Wow that’s really good.

Evan Brand: What are you– what are you popping? ___[02:52], what is he swallowing?

Dr. Justin Marchegiani: Oh yeah, sorry about that.

Evan Brand: [laughs]

Dr. Justin Marchegiani: I should had just turned out my mic so it wasn’t– it wasn’t grabbing it. Uhm– but, it’s B-Vitamins, carnitine, creatine, uhm– ribose, all of the mitochondrial nutrients that we need to help maximizing burning fat for fuel. So–

Evan Brand: Let’s talk about creatine. You– you men– you brought up creatine. Now, you know, people out there may say, “Oh, well creatine isn’t that for your muscles, isn’t that I should be using to increase muscle mass at the gym?”.

Dr. Justin Marchegiani: Yeah. [crosstalk]. It increase growth hormone too. It’s– it’s instantaneous muscle fuel. Uhm– but yeah, it’s– it’s really important for the mitochondria of course. And it– it’s fuel that can be used by the muscle right away. And again, what I like about the creatine is the fact that there is some in– in me, but the problem is not a lot like, 5 or 10 grams that I may get supplementally, you know, maybe a couple hundred milligrams in a mitochondrial support. But if I use creatine before the gym, Im– if I do like a kre-alkalyn or a creatine monohydrate, I’m gonna do 5 or 10 grams, and you don’t have to eat 20 or 30 pounds of meat to get that kind of creatine. So it’s nice to be able to supplement that just because the food wise, you’re not gonna get the same level of concentration. So there’s some really good benefits in there on the supplement side, especially for the lack of having to eat that much meat, it’s impossible.

Evan Brand: Right. Yeah, carnitine, let’s talk about carnitines. So, there’s a ketone and fatty acid section on the organic acid test. So we can kind of look at this and– and we can see whether someone’s been fasting or whether they’d been on like a ketogenic diet. And we can also tell too when there’s metabolism issues or metabolism defects you could call on, on the O-test. Now, what the prescription generally is for this when we see that these markers go high, the prescription could be acetyl L-carnitine, and very helpful for brain fog too. You know, we know– we had a lot of people that say, “Oh, I just don’t have the mental energy or the physical energies”. So they’re mentally tired, so they don’t have the motivation to get things done. That could be in– tied into amino acids but, for this conversation, it could be tied in to carnitine deficiency. And that also, like you mentioned is important for energizing and helping mitochondria, so if you’re a carnitine deficient, you literally, or not making enough energy at the cellular level. And you can replace carnitines supplementally, but as you mentioned, you do want the good meats in the diet. That’s why we see so many vegetarians and vegans, they show low on things like this on the test.

Dr. Justin Marchegiani: Exactly, and if you look at carnitine, you know, what its job is, you go to any biochemistry textbook, you’ll find something known as the carnitine shuttle. And the carnitine shuttle, it essentially shuttles free fatty acids into the mitochondria. Let me see if I can find uh– my biochemistry– come on, one sec. Let me see if I have it close by. Yeah, I do, right here– here– alright.

Evan Brand: So free acid– so– so that– so this has to come from the diet. You’ve gotta have some free fatty acids coming, so–

Dr. Justin Marchegiani: Yeah, so you need the– so number 1, the carnitine shuttle’s really important because it’s gonna take free fatty acids, and it’s gonna dump it into the mitochondria, right, and then the body’s gonna be able to burn that up for fuel. But the other really-really important part– so carnitine shuttle is 188, 189– so we’re doing this on the fly here guys. We’re keeping it real for ‘ya all, okay? I’ll try to be the– the mayor or real ville here.

Evan Brand: [laughs]

Dr. Justin Marchegiani: Okay.

Evan Brand: I see.

Dr. Justin Marchegiani: 189. So, off the bat, we have carnitine right here. This is the mitochondrial matrix.

Evan Brand: Go a little higher, we can’t see it yet.

Dr. Justin Marchegiani: Oh, sorry.

Evan Brand: There you go.

Dr. Justin Marchegiani: Oh, you could see it right here, your body is using carnitine right here. So this is the inner mitochondrial membrane. This is the outer, mitochondria membrane. So essentially, you could see carnitine is literally bringing all these good fatty acids inside the mitochondria. So you need carnitine to bring it inside the mitochondria. Now couple of things I wanna highlight here, is to make carnitine– you actually need– right here, check this out.

Evan Brand: Go a little higher if you want us to see– oh, right there. Okay, yeah, we can’t read it, it’s too small.

Dr. Justin Marchegiani: [reads], carnitine can be attained from the diet where it’s from primarily in meat products. Carnitine can also be synthesized from amino acids, lysine and methionine, by a systematic pathway from liver, therefore these tissues are totally dependent on carnitine provided by the liver. And then there’s one more part in here that it talks about vegetarian diets are primarily deficient in methionine and lysine.

Evan Brand: Right.

Dr. Justin Marchegiani: So what does that mean? If you’re vegetarian, it’s a chance that those nutrients are gonna be low, you’re not gonna be able to make, ’cause you’re gonna go take carnitine in from animal products – meat, right? Or you make it from methionine and lysine. And if vegetarian diet are primarily deficient in methionine and lysine then you’re gonna have problem generating ATP, right? Adenosine Triphosphate, that’s the currency the ener— the energy currency in our body. We’re gonna have problem being able to generate that, being on a vegetarian diet.

Evan Brand: And what does that mean? In short, you’re gonna be tired. And this is why you go to your doctor, and they may try to diagnose you with chronic fatigue, or they may try to diagnose you with ADD, or ADHD so they can give you a methamphetamine derivative such as adderall or vyvanse to try to crank up your energy. You may be dependent on coffee to get yourself up and going in the morning. It’s not a coffee deficiency as some may want us to think. Or– you know, my wife, she loves her coffee but I’ll tell her, it’s not– a coffee deficiency, you know, it could be carnitine. What else you got for us?

Dr. Justin Marchegiani: So– so right here, check this out. So this section right here, it’s called “E”, it’s called carnitine deficiencies. Such deficiencies result in decrease ability to use long chain fatty acids as metabolic fuel, right? So saturated fatty acids, right– the m— the medium chain ones are– coconut oil, those kind of things. The longer ones are gonna be like our– our saturated ones are animal fats. Uhm– but right here, it says, “Secondary carnitine deficiencies may occur for many reasons including patients with liver disease, number 2 is individual suffering from malnutrition. Or– those on on strict vegetarian diets”.

Evan Brand: Boom! There is it.

Dr. Justin Marchegiani: And it also talks about severe infections, burns, trauma, pregnancy, as other mechanism or means in why you would be low in the carnitine, Isn’t that interesting?

Evan Brand: That’s crazy. Well that first paragraph you read, it said something about how you could source it from lysine and methionine as well but it requires an enzymatic process in the liver. And I thought, well, what about all these people that had toxic livers? They’re probably converting it the way they should–

Dr. Justin Marchegiani: Mmmhhhhmm–

Evan Brand: So someone could say, “Oh, I’m tired”. And they could have meat in teh diet but it could be a liver problem, as well.

Dr. Justin Marchegiani: Exactly. Exactly, so– I wanted to just highlight there. A lot of people think vegetarian diets, you know are– are healthy but you’re missing key important nutrients. We’re not even talking about B-12. We’re talking about, you know, important self rebate– or important amino acids and methionine and lysine. And we’re talking about even B-12 and other essential fatty acids. We– we’re not even getting to Vitamin-A. Now people may say, “Wow you’re getting beta carotene”, yeah, but, you may not be converting beta carotene to Vitamin-A. One mechanism is if– if you see like people that have a little bit orangy kind of palms, that can kinda tell you that– uhm— you’re not converting it. Lower thyroid people have a harder time converting beta carotene to Vitamin-A as well. So, these just things you wanna keep in mind. And, some of the organic acids we’ll look at are ethyl malonate, and suberate, and adipate. These are the big ones that we’ll look at and if we see them go really high, it tends to mean that we’re not– uhm— we don’t have enough carnitine on board to really make this carnitine shuttle mechanism happen optimally.

Evan Brand: Yeah so– so even if– so– so you’re saying if that’s happening, even if the diet does have meat, so let’s say somebody’s following a paleo template–

Dr. Justin Marchegiani: Mmmhmm–

Evan Brand: You’re saying if we see high on these markers here–

Dr. Justin Marchegiani:  Mmmhmm–

Evan Brand: –we know that carnitine shuttles’s not happening. They’re still gonna be tired regardless of whether they’re paleo or not.

Dr. Justin Marchegiani: Yeah, I mean, it’s gonna mean that pe– these people are not generating energy from they’re fat optimally, and that’s important. We wanna make sure we have good fatty acid energy uhm— that’s happening. And also we wanna be able to burn fat for fuel. So if we see people that have carnitine issues and we see weight loss challenges, well then we definitely wanna supplement carnitine, you know, I– I would say between 2 to 5 grams, uhm— daily. We wanna be doing that to really enhance fats kind of breakdown. So for— we have fat loss resistance or fat loss struggles and we see issue with carnitine, you really wanna make sure we’re getting good carnitine on the food, right? Animal products, methionine, lysine, those kind of things. And then we wanna make sure that we supplement that on if– if we have other stressors on top of it, so really make sure that its pathways are working well especially if we see the ethyl malonate, the suburate, the adipate in the organic acids being uh– a little bit more impaired.

Evan Brand: Well let me ask you this, I know you’re a big fan of free-form amino acids. So will this be another good time to throw those in because you mentioned like lysine, methionine in this process, could that help, if you wanted to throw it in along with carnitine?

Dr. Justin Marchegiani: Yeah, I think so. I mean, if you look on the– I think marker 7 through 14, there’s some areas that will correlate or look at the amino acids, and so that’s good to look at. So if we see lower amino acids, we wanna give a free-fatty acid formula. And again, amino acids gonna be low for two reasons, from an absorption reason, from a he— or 3, from an absorption issue, you’re not absorbing it too, you’re not– you’re not eating it, right?

Evan Brand: Yup.

Dr. Justin Marchegiani: And– and 3, you know, we may even wanna just supplement it on top of it as well. On the s– the stress part. So the stress part is a third one where you’re just burning up ’cause of stress. You’re– your’re just more catabolic.

Evan Brand: And that could be gut stress.

Dr. Justin Marchegiani: Yeah. You’re not eating it, you’re not absorbing it, gut stress is more of your absorption.

Evan Brand: Yeah.

Dr. Justin Marchegiani: And then just the overall stress part you’re more catabolic and breaking it down. And so, we would add in additional amino acids if we saw some of those pathways low. And the reason why it’s nice, there are a lot of energy, 50% of the energy that you get from the aminos actually goes into the breakdown. So it’s kind of like–

Evan Brand: Aaah–

Dr. Justin Marchegiani: It’s like using a credit card and having a 50% transaction fee, right?

Evan Brand: Ooh–

Dr. Justin Marchegiani: You buy something for a hundred bucks, well you get charged a hundred and fifty ’cause of that 50$ transaction fee on top of it. The nice thing about aminos, is– you get uhm— easy absorption ’cause it’s on a free form so it’s already broken down for you, that’s the benefit.

Evan Brand: Ho– how often do you use those and what’s like the typical case when you’re using free form aminos?

Dr. Justin Marchegiani: I don’t particularly use free form aminos myself ’cause I don’t have those markers coming back on my organic acids, but the uh– the big aminos that I will use are collagen peptides. Collagen peptides are amino acids primarily from connected tissues and much higher in glycine. Like a free form amino acid product like a ___[13:27], it’s amino acid supreme. It’s kind of more balanced across the board, where obviously connected tissue is higher in glycine, it’s lower in methionine, lower in ___[13:38], lower in uhm— uh– tyrosine but it’s higher on the other aminos, hydroxyproline, proline and glycine. And so I use those primarily, but with patients if I see those pathways coming back, or I see vegetarian issues, we’ll go with the amino acids, we’ll aso go collagen, and then we’ll add in some of these carnitine or like a mitosynergy or mitochondrial support that has a lot of those nutrients in it as well. It’s kind of we–

Evan Brand: Oh, okay. So you could do both. You’re saying could put, you know, somebody who is like an ex-vegan or vegetarian, you may put them on amino acid free form, as well as collagen, correct?

Dr. Justin Marchegiani: Absolutely. Absolutely.

Evan Brand: Cool. That’s awesome. So you mentioned the B’s, you mentioned the C’s, we talked about aminos, we talked about the carnitine shuttle, uh– mitochondrial toxins, I mean, why do these happen in the first place. We’ll use either some type of underlying toxicity that’s affected the mitochondria, so– that could be antibiotics, that could be various toxins that we test for, like gasoline additives, xylene for women wearing perfume, that’s a big, big toxin we see, cosmetics, hair dye, we see a chemical called acrylamide that we can test for, that affects mitochondria. So toxins in general, infections like Justin mentioned in the gut, so, getting your gut checked out for parasites, bacteria, H-pylori, worms, etc., candida overgrowth could all steal nutrients as well. Uh– I had one other toxin in mine. It was the xylene, the acrylamide we see, oh, pesticides, I mean, duhh, that’s easy. I mean–

Dr. Justin Marchegiani: Yeah, pesticides, the antibiotics, right? I would say–

Evan Brand: Lots of chemicals?

Dr. Justin Marchegiani: ___[15:06] products. Yup. I think those antibiotics are a big one too, so be careful on that. If we need to use antibiotic we don’t wanna make sure it’s specific and try to maximize the natural herbal compounds first. Uhm– so B-Vitamins, carnitine, creatine, cocutane’s another big one. Cocutanes’ really important, it helped gather all those hydrogens. Better spit out after the uhm— when it goes to the electron transport chain. And through, you know, goes to the krebs cycle electron transport chains, helps gather all those extra hydrogens. Right, we have all these ro— re– reduction reactions that occur uhm— during the kreb cycle which is basically an increase in these electrons that are– and– and the cocutanes gather a lot of them up. And it just spits out more ATP af–after it goes to the electron transport chain. So it’s really important for generating more fuel, more energy.

Evan Brand: My mitochondria showed some– some dysfunction. I got my uh– GPL-Tox chemical test done, and I did have some dysfunction. I wasn’t bad, but I had, I was a– I was a couple point off. I was like in the green, headed towards the yellow. So, I’m doing some of the mitochondrial support nutrients right now. And also, uh– you and I were looking at my blood work. My homocysteine was up a bit too. And that was due to my– uh– folate, B-12, B-6, deficiencies. The B-12 actually looked okay on the O-Test, but the B-6 was a bit low. Folate metabolism looked okay, so, maybe it was just B-6 causing homocysteine to go up, I don’t know. That’s– it [crosstalk] something else.

Dr. Justin Marchegiani: So– some of this could be genetic, some could be stress-based–

Evan Brand: Yeah.

Dr. Justin Marchegiani: So I mean, the best thing is you’re diet’s great and checked out often, “Hey you do your best to manage those stress”. You know, you work with– on the general public, and– and helping them get help this– that– that always can be stressful. And then we just supplement. We make sure we have high quality, uhm— methylated B-Vitamins that are gonna help with that. So we just kinda hit it from all ends.

Evan Brand: Yeah.

Dr. Justin Marchegiani: Uhm– do you wanna hit a couple questions that are related to this topic?

Evan Brand: Yeah, I’ve been– I’ve been firing the chat up so do you mind uh– bringing them?

Dr. Justin Marchegiani: Yeah, so I’m gonna just– if you guys can kind of keep the questions to these specific topics, that’s gonna help. Uh– if not we’re just gonna go through and– and cherry pick ’em. Uhm– “Any supplements or strategies that–“, nope, that’s not gonna be pertinent, sorry. Let me keep on rolling here. “How about P-Protein for a vegetarian diet?”. Yes, P-Protein is really good, you could do P-Protein, you can also add in free form amino acids as well. Those are some g– great options, I think it’s very good. Uhm– Alesson writes in, “I react to all animal proteins, autoimmune disease, etc., ___[17:32] toxic too from iron overload”. Well that’s pretty– it’s interesting, if you’re a female, you should be menstruating unless you know, unless you’re menopausal then it’s totally different. But if you’re cycling female you should menstruating, so having iron overload is pretty hard to do. Now if you’re amenorrhea because your hormones are offline, uh– your iron may also be artificially high ’cause of inflammation. Inflammation can increase uhm— you know, basically iron can act like a reactio— reactive oxygen species, ROS, so it’s like gasoline in the fire. So like an artificially, look like it goes higher, but it’s more of a result of inflammation, so it could be at too. But yeah, you’d wanna do kind of a GAPS, SCD, autoimmune template, maybe elemental diet to kind of get the inflammation under control. For sure–

Evan Brand: Uh– let me add a couple– couple comments to that. You know, I’ve discussed this before with meat. You know, meat gets the– it– it gets the blame, right? Like people will blame the eggs, or they’ll blame the animal protein, but I would go as to far as to say– there’s probably an infection component here which is why you can’t tolerate the meat. So if it’s all meat, I mean if it was red meat, I’d say, well, you know, we have some clients that have had a tick bite and they become allergic to the red meat. But if you’re saying it’s all meat, to me I bet there’s something going on, potentially H-Pylori–

Dr. Justin Marchegiani: With the gut. 100%.

Evan Brand: Yeah–

Dr. Justin Marchegiani: They gotta go to the 6-Rs–

Evan Brand: [crosstalk]

Dr. Justin Marchegiani: They gotta go to the 6-Rs. Yeah they gotta remove the bad foods, replace the enzymes, repair the gut lining, the hormones, remove the infection, repopulate, reinoculate, probiotics retest. But in the meantime, pre-digest all that food, get on a really hypoallergenic, easy to– to process diet, and then pre-digest all that food with– with good cooking methods to help.

Evan Brand: Yup.

Dr. Justin Marchegiani: Excellent. Let’s see here any other questions. Uh– doctor Jack Cruz says “only about one third of energy comes from food”, well, I mean, you know, we’re gonna be tapping in if or more ketogenic or we’re lower carbohydrate, we’ll be tapping in more to our body fat, so there is that, right? Just tapping into our body fat. Uhm– you got about one day’s worth of energy stored in carbohydrate, about 30 days worth of energy stored in fat. So it makes sense to really tap in to that. Uhm– and then regarding– so I guess it depends, right? ‘Cause you– you’re gonna be burning some on your body, some on– some from the food and some of the other food will be building blocks for your muscle, for your mitochondria, like actually, regenerating your body. So, I mean, I guess depends. Err– like– I– I kinda think of like regeneration is like, okay it’s going into the savings account, I think of like burning it’s going into the checking account that’s being spent right away. So we kinda have like our savings account, our checking account for right away, our savings account for regeneration. And then like, we basically have our long term savings which is more tapping into like our fats for fuel, etc. Does that make sense?

Evan Brand: Yeah, are they– are they trying to say like the other part of it like sunlight, I know– you and I have both done multiple podcast. Jack Cruz is in– a mutual friend of ours so we’ve chatted with them plenty of times. You know, sunlight is– is huge. We’re not saying that you– uh– you can ignore that. You still need exposure to sunlight. That’s just the [crosstalk] though.

Dr. Justin Marchegiani: Yeah. The problem with Jack Cruz is this, alright. From what I understand, Jack does not work with patients on the functional medicine side directly, okay? And I can tell you, I wish it was as simple as, no EMF, get Vitamin-D, eat lots of seafood, avoid inflammatory foods, and everyone was healed. It would make my job a thousand times easier, right? So of course, part of a– a good healthy lifestyle is mitigation of EMF. It’s gonna be “Get sunlight”, it’s gonna be grounding, it’s gonna be doing all those things. I can tell you personally, that very rarely is enough. I wish it was, it’d make my life a thousand times easier. I don’t– you know, I wouldn’t– I wouldn’t invalidate doctor Jack for saying any of the– any of those, I think they’re really helpful and they’re good foundational principles to add into your repertoire but they are not the holy grail, that is not it. You gotta do more than that. Doing that is not gonna fix an infection, it’s not gonna fix, you know, poor digestion, nutrient deficiencies, toxic overload, you need extra support above and beyond that. I think it’s important but not the whole story.

Evan Brand: Yeah, like gasoline additives for example, you know, you could set out naked in the sun for 12 hours, you’re not gonna detox, these– these things that are deeply stored inside of us no matter what you do unless you really start to use some nutrients to focus on that. Or you’re doing something maybe like a near infrared sauna or something else to help penetrate. You– you just can’t get the penetration level that you need from just sunlight alone to help with toxins. And then the infection piece like you said, I had H-Pylori, I had giardia, I needed herbs to clear those things out.

Dr. Justin Marchegiani: Exactly. Yup. So just keep that in the back of your mind. Again, you know, I don’t have a dog in the fight, I just wanna make my– my tool bag, right? The tools that I utilize to help patients uhm— get bigger and better so I can help more people, like, I don’t have an affinity to use a screwdriver over you know, a wrench, monkey wrench so to speak. I– I don’t care, right?

Evan Brand: Yeah.

Dr. Justin Marchegiani: Think of like the monkey wrench being like this supplement or that test, or this diet, I– I don’t care I– I’m result driven. A lot of people, they wanna market themselves so they’re– they’re– they need of what they say to be unique ’cause they’re not necessarily results driven, they’re more marketing driven. So, you just kind of keep that in the back of your head.

Evan Brand: Yeah, so to all just add at one last comment, we’ll move on. So if you gp to a lime expert for example, they’re gonna blame everything online. And if you go to a Hashimoto’s expert, they’re saying everything’s your thyroid, you go an adrenal expert, everything is adrenals, adrenal fatigue, adrenal dysfunction, you know, so– we– we try to be specialist and generalist at the same time, meaning, you gotta address all biosystems. So it’s not that these people are wrong, and it’s not that these people are right. It’s that everybody has the piece to the puzzle. Now if you’re business model, selling books on genetics, you need to talk about genetics a lot. If you’re book is on adrenals, you gotta talk about adrenals a lot. But, you’ve gotta have all of it. So why limit yourself, because like you say, it– at the end of the day, all that matters is, did the person get better? Yes or no. If the answer is no, then you’ve got to open up the tool bag to more tools.

Dr. Justin Marchegiani: That’s it, a hundred percent. Another question came in here, uhm— CoQ10, ubiquinol, ubiquinone– ubiquinol from ___[23:30] is a reduced form, so it has an extra electron, uhm— ubiquinone uh– obviously doesn’t have that extra electron. Ubiquinones were a lot of the– you know, the research is, uh– ubiquinol it’s– it’s like one less enzymatic kind of conversion so they’re supposed to be a better reaction, a better conversion or absorption. Uhm– if you’re older, not as much studies on the ubiquinol therefore I still use the ubiquinone but I think, ubiquinol could– it– it’s promising and potentially if you’re older, that may make sense but if not, you know, 3 to 500 milligrams of ubiquinone is gonna be helpful. A lot of good research on that, just make sure it’s good quality.

Evan Brand: Especially if you’re taking statins. ‘Cause we know statins deplete CoQ10 and statins are pastel like candies. So if you’re doing one, gotta make sure that’s in the– in the protocol.

Dr. Justin Marchegiani: Yeah you have this uhm— this methylmalonic acid pathway, right? So you have essentially this HMG-COA reductase enzyme, right? And this, it gets to blocked out by statins, so you have like cholesterol, and uhm— essentially this enzyme is what– ugh– let me think–

Evan Brand: I’ve seen the picture. I know exactly what you’re talking about.

Dr. Justin Marchegiani: One more step down, it’s actually– you have, this HGM-COA reductase enzyme, and then cholesterol gets made, and then you have all these different important antioxidants like CoQ10, and all these other, the sterol compounds that come off of it. So we have this HMG here, cholesterol here, so it blocks this conversion so you don’t get the CoQ10, you don’t get these other important antioxidants that– that come off of it. Uhm– that’s the problem. Now, insulin is one that actually upregulates that enzyme so it causes more cholesterol. So a lot of people can actually get their cholesterol modulated by just getting inflammation under control, getting insulin under control, by getting their carbs dialed in. But uhm— first thing I would say is, you– you need CoQ10, so if you are using a statin you really have to– you know, really get that addressed on the CoQ10 side. Now we’ll look again in the inflammation and the insulin under control first. You may not even need a statin.

Evan Brand: Yup, well said.

Dr. Justin Marchegiani: Okay, excellent. Alright anything else you wanna mention here Evan before we go?

Evan Brand: I think that’s it, we’ll just mention the websites so people can reach out if they need help.

Dr. Justin Marchegiani: Yes.

Evan Brand: You can check out justinhealth— it’s justinhealth.com, you could reach out for consult. Justin works for people around the world, skype, phone, Facetime, whatever you gotta do to get in touch with you, that’s what he does. Same thing for me, my website’s evanbrand.com. We’ve got combined total of 500 and something pieces of content. Uh– just among the podcast alone. So if you all had a specific topic that you wanna see if we’ve covered, just search justinhealth in the topic or evenbrand in the topic, I bet we’ve covered it. And uh– Jack Cruz, you know, uh– we’ve interviewed him, Justin has, I think I’ve had Cruz on my show maybe like three times. The last time we were talking all about 5-G and– EMF and all that and why he feels so good in Mexico, pretty interesting. So, check it out if you want to.

Dr. Justin Marchegiani: Excellent. Alright Evan, great chatting with you, again, give us subscri— a subscribe, give us a like, hit the bell so you get the notifications here later. And appreciate you guys. Sharing is caring. Any help we’re here for you all. You guys take care. Evan, have a good day.

Evan Brand: See you later, bye.

Dr. Justin Marchegiani: Bye.


References:

https://www.evanbrand.com/

https://justinhealth.com/


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