Description
Licorice Drops – Precision Cortisol Preservation System
When we started working with people dealing with chronic fatigue and what's often called “adrenal fatigue,” we discovered something that conventional medicine frequently overlooks: many people don't have low cortisol production – they have accelerated cortisol breakdown. Your adrenals might be working perfectly fine, but if your body is rapidly converting cortisol into its inactive form (cortisone), you'll still experience all the symptoms of cortisol deficiency.
This was a game-changing insight because it meant that simply trying to stimulate more cortisol production wasn't always the answer. Sometimes what people need is to preserve and optimize the cortisol they're already making. That's where licorice root's unique mechanism becomes incredibly valuable – it's one of nature's most effective cortisol preservation compounds.
That's why we developed Licorice Drops as a precision cortisol optimization system. Unlike generic licorice supplements that may or may not contain therapeutic levels of active compounds, our standardized extract delivers exact amounts of glycyrrhizin – the specific compound that blocks cortisol breakdown. This targeted approach allows for precise cortisol support without the guesswork of unstandardized products.
Why We Created This Targeted Formula
After extensive research into cortisol metabolism and adrenal physiology, we realized that most people misunderstand how cortisol regulation actually works. Your body produces cortisol in response to stress and circadian rhythms, but it also has sophisticated mechanisms for deactivating cortisol when it's no longer needed. The enzyme 11-beta-hydroxysteroid dehydrogenase converts active cortisol into inactive cortisone.
Under normal circumstances, this system works perfectly. But chronic stress, poor sleep, inflammation, and aging can cause this conversion process to become overactive, leading to cortisol being broken down faster than it should be. The result? Symptoms of low cortisol even when production levels are normal.
The breakthrough came when we understood that licorice root's glycyrrhizin works by temporarily and reversibly inhibiting this breakdown enzyme, allowing your naturally produced cortisol to remain active longer. This is fundamentally different from stimulating more cortisol production – it's about optimizing the cortisol you already have.
Our Cortisol Intelligence Strategy
Here's what makes Licorice Drops different from standard licorice supplements:
Phase 1: Enzymatic Modulation – Standardized glycyrrhizin precisely inhibits 11-beta-hydroxysteroid dehydrogenase to slow cortisol breakdown
Phase 2: Cortisol Preservation – Allows naturally produced cortisol to remain active longer, improving energy and stress resilience
Phase 3: HPA Axis Support – Helps restore more optimal cortisol rhythms without forcing excessive production
Phase 4: Metabolic Enhancement – Preserved cortisol supports healthy metabolism, immune function, and stress adaptation
This sophisticated approach recognizes that cortisol optimization isn't about more or less – it's about better timing and duration of cortisol activity.
The Science Behind Cortisol Preservation
Your cortisol system is incredibly sophisticated, with multiple feedback loops and regulatory mechanisms that control both production and breakdown. Cortisol has a relatively short half-life in your body because it's such a powerful hormone – your body needs to be able to quickly adjust cortisol levels based on changing circumstances.
The enzyme 11-beta-hydroxysteroid dehydrogenase plays a crucial role in this regulation by converting active cortisol (cortisol) into inactive cortisone. This normally happens at appropriate rates, but various factors can cause this enzyme to become overactive, leading to premature cortisol breakdown.
Glycyrrhizin, the active compound in licorice root, works by reversibly inhibiting this enzyme. This doesn't stop cortisol breakdown entirely – it just slows it down to more optimal rates. The result is that your naturally produced cortisol remains active longer, providing better energy, mood stability, and stress resilience without forcing your adrenals to overproduce.
Ingredient Information
Licorice Root Extract (10.5mg from Glycyrrhiza glabra) Our extract is carefully standardized to deliver precise amounts of glycyrrhizin – the specific compound responsible for cortisol preservation effects. This standardization ensures consistent therapeutic activity with each drop.
Glycyrrhizin (0.87mg per drop) This is the active compound that inhibits 11-beta-hydroxysteroid dehydrogenase, the enzyme responsible for converting cortisol to cortisone. The precise dose allows for targeted cortisol preservation without excessive inhibition that could lead to side effects.
Unlike deglycyrrhizinated licorice (DGL) which has had the glycyrrhizin removed for digestive support, our formulation specifically preserves this compound because it's essential for cortisol preservation. The liquid delivery system ensures rapid absorption and allows for precise dose titration based on individual response.
Glycerin (from certified sustainable palm oil) This natural carrier and preservative helps stabilize the licorice extract while providing a pleasant taste and smooth absorption. Glycerin also has mild anti-inflammatory properties that complement the licorice root extract.
Purified Water Used as a natural solvent and carrier to create the liquid extract format that allows for optimal absorption and precise dosing.
How This Formula Works
Licorice Drops support cortisol optimization through a precise biochemical mechanism:
Selective Enzyme Inhibition: Glycyrrhizin specifically and reversibly inhibits 11-beta-hydroxysteroid dehydrogenase, slowing the conversion of active cortisol to inactive cortisone.
Cortisol Half-Life Extension: By slowing breakdown, naturally produced cortisol remains active longer, providing extended energy and stress resilience benefits without forcing additional production.
HPA Axis Optimization: More efficient cortisol utilization can help restore healthier cortisol rhythms and reduce the stress on adrenal glands to overproduce.
Metabolic Support: Preserved cortisol supports healthy blood sugar regulation, immune function, and overall metabolic efficiency.
What Makes Our Formula Different
We've focused on creating the most precise and effective cortisol support possible:
- Standardized Potency: Each drop delivers exactly 0.87mg of glycyrrhizin for consistent and predictable effects
- Liquid Precision: Allows for exact dosing and easy adjustment based on individual response and sensitivity
- Rapid Absorption: Liquid format provides faster onset and more reliable effects compared to capsules or tablets
- Pure Focus: Single-compound formula eliminates variables and allows you to experience licorice's specific cortisol preservation benefits
Recommended Protocol
Here's how we suggest using Licorice Drops for optimal cortisol support:
Assessment Phase (Week 1-2): Start with 8-10 drops once daily, preferably in the morning when cortisol levels are naturally highest. Monitor your response carefully, as cortisol support can have noticeable effects.
Optimization Phase (Week 3-6): Based on response, you may increase to 8-10 drops twice daily if needed. Some people find morning-only dosing sufficient, while others benefit from divided doses. Individual needs vary significantly.
Maintenance Phase (Week 7+): Continue with the dose that provides optimal energy and stress resilience. Many people use licorice cyclically rather than continuously to prevent tolerance and maintain effectiveness.
Important Timing Notes: Morning dosing supports natural cortisol rhythms. If using twice daily, take the second dose by early afternoon to avoid potential sleep interference. The liquid can be taken directly or mixed with a small amount of water.
What to Expect
Timeline: Many people notice improvements in energy and stress tolerance within the first week because glycyrrhizin works immediately to preserve cortisol. However, optimal cortisol rhythm restoration typically takes 4-6 weeks of consistent use.
Everyone's Different: Your response will depend on your current cortisol patterns, stress levels, overall health, and individual sensitivity to cortisol preservation. Some people may notice dramatic energy improvements quickly, while others experience more gradual benefits.
What You Might Experience: Most people find that cortisol preservation provides sustained energy without jitters or crashes. You might notice improved morning energy, better stress tolerance, enhanced mental clarity, and more stable moods. Some people also report improved exercise tolerance and recovery.
Product Specifications
Serving Size: 1 drop (0.05 ml)
Servings Per Container: Approximately 1,200 drops (60 ml bottle)
Active Ingredients: Licorice Root Extract (Glycyrrhiza glabra) 10.5mg per drop, standardized to deliver 0.87mg glycyrrhizin per drop
Other Ingredients: Glycerin (from certified sustainable palm oil), purified water
Manufacturing: Produced in a GMP-certified facility in the United States. Every batch undergoes testing to verify glycyrrhizin content and purity.
Quality Information
Each batch undergoes comprehensive testing including:
- Glycyrrhizin standardization verification through advanced analytical methods
- Heavy metals analysis (lead, mercury, cadmium, arsenic)
- Microbial contamination screening
- Pesticide residue testing for botanical ingredients
- Identity confirmation of licorice root extract
- Stability testing to ensure consistent potency over shelf life
Purity Guarantee: Our product is free from egg, dairy, shellfish/fish, tree nuts/peanuts, soy, gluten, bromelain, corn, artificial colors/flavors, sodium, sugar, rice, and is non-GMO.
The licorice root is sourced from premium suppliers and processed using gentle extraction methods that preserve the full spectrum of beneficial compounds while concentrating the active glycyrrhizin.
Important Safety Information
Do Not Use If You Have:
- High blood pressure or hypertension
- Heart failure or cardiovascular disease
- Kidney disease or impaired kidney function
- Liver cirrhosis or cholestatic liver disorders
- A history of electrolyte imbalances
Consult Your Healthcare Provider Before Use If:
- You are pregnant or nursing
- You have any medical conditions, especially cardiovascular or kidney disorders
- You take prescription medications (particularly blood pressure, heart, or diuretic medications)
- You have a history of edema or fluid retention
Use With Extreme Caution If:
- You have any cardiovascular risk factors
- You take medications that affect blood pressure or electrolyte balance
- You have diabetes (licorice may affect blood sugar)
Managing Supplement Reactions: If you're experiencing negative symptoms that are impacting your quality of life, discontinue use immediately and consult your healthcare provider. Licorice can cause significant side effects including elevated blood pressure, fluid retention, and electrolyte imbalances that require medical attention.
Potential Side Effects: Licorice can cause elevated blood pressure, fluid retention, potassium depletion, sodium retention, and in severe cases, a condition called pseudohyperaldosteronism. These effects are dose-dependent and typically reversible with discontinuation.
Important Notes:
- This is a potent botanical that can significantly affect cortisol metabolism and cardiovascular function
- Regular monitoring of blood pressure and electrolytes is recommended with ongoing use
- Not suitable for long-term continuous use without medical supervision
- Should be used cyclically rather than continuously to prevent tolerance and side effects
Storage: Keep in a cool, dry place away from direct sunlight. Keep out of reach of children.
Professional Guidance Strongly Recommended
Due to the potent effects of licorice on cortisol metabolism and cardiovascular function, we strongly recommend working with a qualified healthcare practitioner who can:
- Assess whether cortisol preservation is appropriate for your specific situation through proper testing
- Monitor your blood pressure, electrolyte levels, and overall response
- Determine safe and effective dosing based on your individual health status
- Provide guidance on cycling protocols to prevent tolerance and side effects
- Coordinate with any other treatments or medications you may be taking
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
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