How to Boost Nitric Oxide and Oxygenation in the Body – Can Help with Viruses | Podcast #280

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We have another episode of Beyond Wellness Podcast. In this episode with Evan Brand, we discuss nitric oxide, how nitric oxide works and helps our system, as well as improve oxygenation in our bodies. As we all know, many viruses can attack our lungs, making it harder to breathe. And on the functional medicine side, how does Nitric Oxide work in preventing viruses? Read the whole transcription below to find out! Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

2:03     Hypoxia

8:48     Nitric Oxide

16:56   Kidney Disease, Kidney Stress

27:35   Functional Medicine is Important

33:54  Boost your Nitric Oxide Production

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Dr. Justin Marchegiani: All right, and we are live. It's Dr. J here in the house. Today we're going to be chatting about nitric oxide and vasodilation and how we can improve oxygenation in our bodies. Evan Brand, how are we doing today, man? 

Evan Brand: I'm doing really well. Let's talk about the context of this topic. There was a video that you and I watched over the weekend, about a doctor up in New York City ICU unit. And he reported it was like a six minute video. He reported what he was seeing in the ICU, and saying that what the official narrative of the corona virus is saying and what it's causing, versus the reality in the ICU looks different. This guy's name here is Dr. Cameron Kyle side L. And the title of his video was does Covid19 really caused ARDS which is acute respiratory distress syndrome. He talks about here that he believes that we're treating the wrong disease. And this is all quoted here, and that we must change what we were doing if we want to save as many lives as possible. And he goes into this video about how, what he's seeing that with the ventilators, there's all this talk about ventilators, ventilators, ventilators, he sees that it's actually causing more damage because the muscles of these patients he's seeing are actually working perfectly fine. And he's saying what he is seeing does not look like pneumonia at all. Because the the way that the muscle function is looking, it's it's not pneumonia, and he says that it's something else creating this hypoxia and he says something along the lines of it appears that these patients were dropped off at the top of Mount Everest, and they had no ability or no time to adjust to the high altitude. So he says this is almost like a high altitude sickness, and therefore the treatment that we are now implementing across the country and across the globe in the ICU is not properly addressing that hypoxia.

Dr. Justin Marchegiani: Exactly, exactly. So hypoxia is basically lower oxygen levels in the blood. Now people at home can test that by getting a pulse oximeter. You know, once you start dropping below 90, I think a lot of these doctors are more like mid 80s to low 80s is more concerning. And I think you see even some of these people being in the 70s while in the hospital, so there's some ways that we can kind of qualify and quantify it with a pulse ox, which is, which is really interesting to know. Now, the question is that ER Doctor, his video is quite interesting. We kind of walked away from it, where he kind of implied that the ventilator should be used, but they should be used kind of in a different manner. And that was really interesting because he didn't really say how it should be used differently. So if any er doctors or people who are medical professionals that have experience using vents, I'm just curious right down below what kind of different setting options could be used. If this is not necessarily an acute respiratory distress. Issue, this is more of a hypoxia issue. How could that be used differently to help that situation? So I'll pose that question for any of our medical allopathic listeners.

Evan Brand: Yeah, that would be awesome if we could get some answers because he didn't provide the answers there. He just said, hey, what we're doing, I think, is actually killing people. He didn't say, flat out x equals y or X causes Y. But basically, long story short that the ventilators may be resulting in more deaths, because there's too much pressure on the lungs because the person is breathing just the way they should plus the extra pressure of the vent is just too much and it's damaging people. So-

Dr. Justin Marchegiani: I heard that a doctor an anesthesiologist chime in and say, What about a hemo lung, and hemo lung is interesting because basically it's going in at the carotid artery level going down to the heart and hemo lung is used for like lung transplants and heart surgeries. Basically, it takes the blood out of the heart, brings it into this little device and it re oxygenates it and then brings it back into the heart. So then when it when it goes up to the to the left atrium down to the left ventricle, it's already oxygenated. So that was interesting because then it takes away all of the the breathing and the pressure on the lung and it oxygenates the blood right at the heart level, which I thought was interesting. And maybe that technology, maybe it's too invasive. Maybe there's not enough of those devices. And we're already short with the events. And maybe that's just more of an impossible feat. So anyone that has experience with the hemo lung, I'm really curious to know if that could be a good option to decrease the hypoxia as well.

Evan Brand: Yep, yep. So all that backstory leads into today's conversation, which is, well, what are things that we can do on our end, maybe if you would call it preventative? Now what I say that what we're going to talk about today is something that you would want to implement if you were in an ICU unit and try to save your life by taking extra beet powder, for example. No, that's not what I'm going to say at all. But I'm hoping that just by learning about some of these mechanisms in the body, you can become more educated and then you can have strategies that you implement on a daily basis to boost yourself up. Increase the cell to cell communication that happens the vasodilation that happens the proper regulation of inflammation that happens the neuro transmission that happens there's a lot of stuff that is related to nitric oxide. So let's give some people just a little bit of background on nitric oxide, kind of how it works. And then we'll dive into you know what goes wrong. If you are even just aging, just aging alone reduces oxide, we found.

Dr. Justin Marchegiani: And because we're kind of talking about some of the corona virus stuff, right. And there's some first line therapy that that's really promising, ie the, the hydroxychloroquine or the chloroquine, which is which is interesting. And as well as combining it with the azithromycin and the zinc. And if you notice, a lot of people out there aren't talking about the zinc component in this whole thing. So I think that is important. Also, if you're in the hospital, I'm not sure what kind of requests you could make to some of these conventional Doc's about intravenous nutrients. So I'm in the hospital, because this is acute which again, 90% asymptomatic, so I personally say If you have a 90% chance of being asymptomatic, well just be healthy enough and boost your immune system enough now, so you're in that asymptomatic camp. But if I'm in the hospital right now, I'm going to be asking for IV vitamin C, I'm going to be asking for IV glutathione. Because a lot of these antioxidants are actually shown to improve nitric oxide levels to improve the effects of nitric oxide in the body. And then also we could supplement on vitamin E. And, you know, various plant based bioflavonoids and polyphenols are all going to be great because they're really high in nitric oxide, nitrogen, and they're also really high in a lot of antioxidant compounds. Just kind of as a side note, hey, you know, what kind of requests can you make? The problem is conventional medicine is so one track, it's hard to kind of come in there and do a different standard of care than the conveyor belt standard of care that's at your fingertips.

Evan Brand: Right, yeah, my grandmother was in the hospital for a fib atrial fibrillation. I spoke with the cardiologist about using motherwort Which is an herb that's great for the heart, and it has some papers on it being shown to help reduce the incidence of a fib or the severity of any heart issues. And he just completely literally rolled his eyes at me and said, No, Evan, we have our medications in place. And I'm like, yep, she was on these drugs. She's still in a fib. You're not fixing the issue with your drugs, you're not fixing the root cause. And they just blew me off and fed her her lunch, which I told you was a peanut butter sandwich with high fructose corn syrup in the cardiac department.

Dr. Justin Marchegiani: Yeah, the problem with a fib which is like the hearts not being in sync with its electrical contractions, a lot of that has to do with like, inflammation and high levels of insulin and not having good adequate levels of electrolytes. But a lot of times, they'll put you on blood thinners, or like a beta blocker, or things like that. And that a lot of times can decrease the minerals and actually make the underlying mechanism worse, and then you're kind of more reliant on the drug forever. And that's the problem with a lot of the drugs is they actually the root cause mechanism is really not addressed. And then now the drug is needed more because that underlying root cause is actually made worse.

Evan Brand: Yeah, it's crazy. So that's pretty much what's happened. And it's really sad to see because, you know, there's good strategies out there that you can implement. But as you mentioned, it's kind of a one track, one track that you get of treatment and beyond that, and that's also what this doctrine that video talks about what the virus issue is that because of the dogma associated with medical doctors, and he is one, that they're not really willing to go outside of the box. So it's sort of just here's the protocol we're doing. you implement this, but he's saying you put people on the ventilator. 75 plus percent of them are dying. So if you get to that point, it seems that it's just not working. But you can't really switch the protocol because that whoever is above making the decision said that's the protocol. So, anyhow.

Dr. Justin Marchegiani: Exactly, exactly. So we're going to be chatting about nitric oxide, which is basically nitrogen oxide and it's double bond that kind of combines it and the 1998 Nobel Prize in Physiology Medicine was actually kind of looking at nitric oxides role in helping with cardiovascular disease. And so that's very, very important because we've known for about 20 plus years this is a really powerful compound. And don't confuse it with nitrous oxide. Nitrous oxide is N2o both are gases, right? nitric oxide is going to be the vevo dilator opens the blood vessels that's n-o double bond. And 2-o is nitris. And that's the laughing gas that though a lot of times they'll you do when you're getting your to pool they're drilling a cavity at the dentist's office so don't, don't confuse the two of those. And again, some big building blocks to make nitric oxide are going to be a lot of the plant based nitrogen compounds like Evan mentioned, beetroot powder is very powerful in helping to provide more nitrogen and building blocks. Also a lot of your green leafy vegetables so a lot of your carrots are a lot of your salaries and to be really powerful out of your lettuces. Spinach, arugula, a lot of your green vegetables, celery in the beet root. Those are amazing, amazing compounds to help provide those extra nitrogens to improve nitric oxide levels in the body.

Evan Brand: Yeah. And people may say, Well, why powder? Why does it have to be a powder it doesn't, you could eat just straight beets if you want to. But for me, I've had much better benefit and it's a little easier for me, I don't have to go and cook anything if I could just open up some organic, non hybridize beet powder. I'll throw that in with a scoop of my electrolyte formula and drink it down. And these, these vegetables that are high in nitrates are what allow you to naturally increase the levels. So it works in the erectile dysfunction department as well. Many people have heard of nitric oxide if they've ever had an ED issue and they try to go on some of these nitric oxide boosters for that issue and it can help. I don't know if the mechanism of some of the conventional drugs like five I work on nitric oxide at all, but I do know that beet powder and other amino acids that you could use arginine citrulline, these kind of things, a lot of them are in bodybuilding type formulas that those can help increase blood flow quite a bit.

Dr. Justin Marchegiani: Yeah, I know Viagra was originally created in that was designed to help with angina with heart pain. And so yeah, it does. Things like Viagra are going to work on localized release of nitric oxide for sure. Yep, that's definitely part of the mechanism. Now, the question is, there's nutrients that run that, right, so the problem with the drug doesn't provide any nutrient to have that pathway run better. So it's kind of working by overriding underlying mechanisms, right? underlying mechanisms that are needed. So the problem over time is you tend to have to increase the dose. So whatever drug you're using, because you weren't fixing the mechanism, that's why adding amino acids like citrulline and arginine are going to be helpful because Those are part of the building blocks to make some of these hormones or some of these, let's just call them hormone like peptides to work in your body. And then also the building blocks in regards to nutrients. So a lot of these greens vegetables we talked about. And then the benefit of like a beetroot powder is just the concentration, you can just get a lot more of it in your body versus eating a couple of pounds of beats. You can kind of get it in a way that's more therapeutic and easier to put in like a general generalized smoothie, if you will.

Evan Brand: Yep. And so why, why this conversation? Well, because not Justin and I did a whole podcast on some of the underlying causes, and some of the comorbidities associated with the virus and if people are ending up in really bad shape, or if it's a fatal case, there's a lot of these comorbidities him and I were talking about this before we hit record diabetes is massive, massive, massive, massive comorbidity put you at increased risk, also hypertension. And so guess what? Nitric oxide has a role and vasodilation therefore, if you have low nitrogen oxide production, which happens just as you age, just the aging process alone, you have reduced No, therefore, more likely to have hypertension. Hypertension is in the top five of the comorbidities of people that are in bad shape with this virus. So if you've got high blood pressure, you are at more increased risk. And we've got a study here 2014 Journal of Clinical hypertension, a single administration of an oral active, no supplement, decrease blood pressure, improve vascular compliance and restored endothelial function in patients with hypertension. So are we saying hey, this is going to get you off the hook? Not necessarily but to me, it sounds like a really, really good tool to have in the toolbox.

Dr. Justin Marchegiani: Very interesting. Yep. Very interesting. Also, we know that things like low thyroid production, low thyroid hormone, are associated with things like low nitric oxide or low decreased nitric oxide synthase, which is part of the enzyme that makes nitric oxide and Evan kind of alluded to it earlier there was an artist In the New England Journal of Medicine that came out within the last two weeks that looked at a lot of these coronavirus patients up in Seattle area, and they saw almost 60% of them had type two diabetes or some kind of pre diabetes. Now why does this matter is high levels of insulin are going to impact your immune cells from gobbling up bad bacteria or viruses, right? We know Corona virus is a virus. And so phagocytosis is the natural process that your lymphocytes or neutrophils and monocytes may engage in to gobble up these viruses. So high levels of blood sugars and increase insulin. That's gonna make it hard to gobble these critters up, but we know people that consume or that have high levels of insulin, what are they consuming? They're consuming a lot more processed sugar, high fructose corn syrup, all those things, people that are consuming excess fructose, right? high levels of fructose are going to decrease nitric oxide, endothelial synthase, that's the enzyme that helps make nitric oxide and your blood vessels so how Having high amounts of carbohydrate and lots of processed refined sugar. One is going to impair your immune system, which is going to make coronavirus, a bigger deal, which then will create that hypoxia. But number two, it's going to decrease the enzyme activation of nitric oxide in your body.

Evan Brand: Yeah, that's crazy. And we were talking about the age factor. So if you're older as well, right? Originally, we were looking at all this stuff from Italy, we were saying, Oh, well, this is a an issue affecting older people. It's also been found to affect younger people. Everybody says, well, oh my god, oh my god. Now it's the young people affected too. But think about how many young, diabetic overweight and obese people we have in America. I mean, we are the most obese country in the world. So I don't think it's fair to look at these headlines and say, Oh my God, this guy was 33 years old because we have the most obesity and diabetes. in that age group. Anywhere I know India, the diabetes rates are going crazy high there as well. But that's not the point. The point is that when you look at the headline you see younger people are dying. That's not actually apples to apples, a younger person who is on a paleo template is going to be, in theory much healthier and less prone to severe complications if they have good blood sugar. And you talked about the the amino acids a little bit so like arginine and citrulline. Those are things that you and I use supplementally what happens is the your kidneys, I didn't know this is actually something I learned today. The kidneys are what turned the citrulline into arginine. And then the arginine is the precursor to nitric oxide. And so when you throw extra supplemental amino acids in there, you're just helping this whole pathway run better.

Dr. Justin Marchegiani: And it's really interesting, right? Because so you're talking about the the citrulline gets converted by the kidneys to origin is that correct? That's right. And we know that guess what, guess where 80% of all kidney disease comes from?

Evan Brand: Hmm, I don't know. 

Dr. Justin Marchegiani: It comes from diabetes. 

Evan Brand: Yeah, I mean, Makes sense.

Dr. Justin Marchegiani: So high levels of blood sugar via excess fructose and crapple hydrates in our diet, that's gonna put a lot of kidney stress. And I'm going to guarantee that with more stress on your kidneys, you're going to have a harder time converting some of those amino acids like the citrulline to arginine and Argentines and help make that nitric oxide which is going to help open up your blood vessels. And so I wouldn't be surprised the more kidney stress you have from excess carbohydrates, sugars slash fructose, and I'm not gonna I'll go out in the limb because we already know the mechanisms there Evan, we know that issues like mold and heavy metals could also decrease nitric oxide and I wouldn't be surprised if part of that mechanism is through stress on the kidneys. What do you think?

Evan Brand: Oh, it makes total sense. I mean, I had kidney pain. I know that was one of my symptoms. When I first got exposed to mold. I thought it was just like adrenal area but looking back it makes more sense that it was actually kidney so I did take some kidney support formulas astragalus and Agaricus, mushroom and some other things to help boost kidney function. Symptoms luckily went away. And also, one of the symptoms of mold exposure is increased urination, especially at night. So we talked a lot of people that talk about their they're up in the middle of the night peeing all the time. That was a mold symptom. And I used to have it I was up four or five times a night peeing. And I no longer have that issue after detoxing and then supplementing with different nutrients for the kidney. So yeah, I think you're, you're definitely spot on.

Dr. Justin Marchegiani: 100%. And I'm looking at a couple of studies here. There is a connection between low levels of thyroid hormone and low levels of nitric oxide and this one study here, that's a review on the topic. But they're definitely talking about more, you know, more studies on humans are needed, but there's definitely a connection with adding in thyroid hormone and helping to improve nitric oxide levels. So this is kind of like the chicken or the egg thing. So I look at a lot of nitric oxide, things are like more downstream, meaning it's like more of an effect than a cause. So we're talking about it here. Because it plays a really important role with oxygenation and the corona virus and some of the disease symptoms that may occur. But people that are listening to this that are functional medicine people, we may be inadvertently helping your nitric oxide levels just by moving to a paleo template. By helping you break down your protein, maybe you're getting more citrulline than your diet. By looking at your thyroid, maybe you have an autoimmune thyroid issue, right, maybe your thyroid is getting destroyed because you're eating a whole bunch of gluten and dairy and processed food, and that's exacerbating your leaky gut and exacerbating your autoimmune issue which could then be affecting your nitric oxide levels. So a lot of times, we may be fixing your nitric oxide by helping your thyroid or by fixing your gut permeability through a gut infection or by assessing mold in your home or heavy metals in your mouth or your environment. So, you know, you don't have to break out fancy supplements every time a lot of times we may be doing this just via diet and other what I call upstream Functional Medicine system assessment to get to the root cause of the system's upstream because above below inside out, if we deal with the system's up here, the symptoms downstream, may improve. And a lot of times that may be through regulating nitric oxide through other upstream things not connected.

Evan Brand: Yeah, it's crazy. I mean, we always talk about how everything's one big spiderweb and it's all connected. But the more we dive into these things and pull things apart, it really is true. One paper here we had showed that roughly 80% of dietary nitrates come from eating vegetables. And so beets are at the top of the list of being rich and nitrates. You've got the leafy vegetables, as you mentioned, like you've got a rubella chard, spinach, you've got broccoli, you've got turnips, cucumbers, carrots, cauliflower, and then also you mentioned from the protein as well so, grass fed beef, wild caught fish, pastured eggs, potentially raw cheese's if you can tolerate them. Pumpkin Spice seeds, sunflower seeds, even spirulina, these are all going to be high and arginine and that's going to help you as well. So this is pretty cool. I mean, it's watermelon was on the list too, which is interesting watermelons really high, apparently in citrulline. So Mm hmm.

Dr. Justin Marchegiani: Very good. I wouldn't be surprised to if we find a connection with thyroid issues and a lot of the oxygenation thing with the coronavirus in this one meta analysis. I think this is powerful because we know nitric oxide and it's a benefits on cardiovascular disease. Right? We could probably ask our friend Dr. Jack Wolfson. On that I know he recommends a lot of nutrients that help improve nitric oxide levels. But in this study right here, the literature discussed in this review together with our published data and preliminary results related to nitric oxide regulation and hypothyroidism suggests that nitric oxide levels could be a reliable marker for thyroid dysfunction as well. So we know nitric oxide can contribute to cardiovascular but they're saying hey, nitric oxide can also be used to assess thyroid issues. hypothyroid now I'm gonna guess it's the low thyroid is probably driving the nitric oxide. I think they have the roles reversed here. But they talk about that, um, that literally giving thyroid hormone giving lt four, which I think is I think they're referring to that as level thyroxine and T4 actually has been used as a therapeutic molecule for improving cardiovascular related disease via thyroid dysfunction. So Furthermore, the newly discovered role of thyroid hormone and the effects of lt four on no production may have broad implications in cardiovascular disease. So meaning what meaning oxygenation and heart health is connected to healthy thyroid. So we know there's a connection between thyroid and nitric oxide, and that's going to help with oxygenation. So if you have oxygen issues, and or health issues there, we got to look upstream to make sure the thyroid is not a problem.

Evan Brand: And make sense why we have the most number so far if you're looking at the statistics worldwide, I mean, we have a ton of people, right, we're very large country, compared to some of these other smaller countries that are running numbers. So there's a lot of factors but you look at the health of the US as a general rule, we're not anywhere close to a quote native diet. I mean, you look at Japan's numbers, Japan has barely been affected at all based on the stuff I've been seeing and these are people who you know, they've got some of the oldest living people on the planet in Japan, they're eating their native diet. I mean, they do do a lot of rice so they probably are higher carbohydrate but just in general, they're eating real food you know, they're doing fish quite often. You go down the street anywhere in America, you're going to find a McDonald's which is going to be hydrogenated oils, massive inflammation, you're going to find high fructose corn syrup and everything. You get the little cinnamon cookies with your kids Happy Meal, that's pure straight sugar, high fructose corn syrup. So it makes sense, right? When people say oh, well, we could have done this better. We could have done that better. I mean, look at the look at the the the template that we started with look at America's Health template as a whole. We were sick as well. As a general rule, you've got the little bubbles like you go to like a health conference. And you'll see everybody's keto. And the women look great. And like, wow, this is what Healthy People could look like. I'm always amazed, aren't you? When you go to health conferences, and you look at people you're like, these are good looking people. These are healthy looking humans. Wow, what a relief from seeing, you know, if you go to, let's say, a theme park, you're going to see the average American, you know, massively obese, eating ice cream versus you go to a health conference, you're like, wow, these are what all humans would have looked like, a couple hundred years ago, or even my grandparents who were farmers, they're my great grandparents who were farmers. They look like these people.

Dr. Justin Marchegiani: 100% I've actually noticed the opposite to some people that health conferences are really unhealthy because, well, part of it is they're kind of on their health journey themselves, you know, true and a lot of times it's all about your starting point. You know, if someone was really overweight, but now they've lost 50 pounds, but there's they're on the right track. A lot of times people are kind of moving into that field because they're a wounded they're walking the path of the wounded healer That's very true. Alex gray says. So sometimes everyone's on a different journey. Right. And so I see that too. But yeah, I've seen it both ways for sure. And, you know, one thing I wanted to highlight from you is, you talked about citrulline. And there is a couple of studies on low citrulline levels and low citrulline. And its effect on nitric oxide. We know that but one thing they talked about, is it how people are dying from this coronavirus is typically acute respiratory distress syndrome, right? That's kind of how everything manifests at the end, and they're talking about nitric oxide playing a big role in that. And they talked about that nitric oxide substrate citrulline would be associated with end organ damage. So essentially, lower levels of citrulline increased more acute respiratory distress issues and sepsis and organ damage. So it seems like loneliness really protective. With this end stage disease failure that you're going to see with these issues.

Evan Brand: That is crazy. I wonder if you could get that I mean, that's problem is, is that readily available that you could get it in IV? If you're in an urgent situation? Or you depending on drinking it, you know what if you're in such bad shape, you can't drink an amino acid blend, you know what I mean? It's just tough. Like, how do you implement some of these things?

Dr. Justin Marchegiani: Well, I mean, if you were IV or worst case, you'd get some type of access port to the to the stomach or the intestines where you could dump the the freeform amino acids. Yeah, in that way. I mean, that'd be the biggest thing. I would, I would think I'm not sure what your options are. And that kind of a crazy surgical session-

Evan Brand: That's the problem too, because when you're in that, as that doctor mentioned, in the video we talked about in the beginning is that it's very difficult. And he actually wrote in the comments too, as well, that he's actually kind of closing up his ICU unit, and he's returning just to the emergency room, because he says he doesn't have faith anymore in the standard protocol. And he didn't say, flat out but I'm kind of reading in between the lines that he's unable to go off of the protocol and try other things. So that's the problem is, let's just say citrulline and Argentina. Are game changers and beet powder and they could significantly boost up nitric oxide to really help reduce the severity of this issue. If you bring that up to your doctor, first of all, they may laugh at you. And then secondly, they may say, Well, we don't have that you got beet powder in your pocket, sir. What do you want me to do? You know, they'll probably give you some kind of smart aleck answer like that.

Dr. Justin Marchegiani: Yeah, exactly. 100%. And again, I just think conventional medicine isn't really equipped to add some of these modalities and just because most of their modalities are going to be drug base.

Evan Brand: Well, they don't have it on hand. They don't have a pallet of beet powder in the back of the hospital.

Dr. Justin Marchegiani: Exactly, exactly. And I really like to see you know, conventional medicine kind of get more hip with functional medicine principles in the emergency setting, right? Because we know a lot of integrative medical Doc's for chronic disease. They're starting to get hip with functional medicine because they're understanding that they're just treating their patients long term with drugs. And it's very expensive, right? If you treat a diabetic with just Metformin and insulin, In all these different things, it's very expensive, over 20 years, it's gonna cost millions of dollars. But we could actually work on getting to the root issue and fix it with diet and lifestyle and specific supplements. So I wish we could see more of that mindset with the acute palliative care. I think we may see even better improvements.

Evan Brand: Yeah, I mean, you and I have several medical doctor friends, some that work in cardiology, some that are emergency room and I bring these issues up all the time, I say, hey, look, if you've got somebody coming in, and they've got maybe some slight elevated blood pressure, and they've got major anxiety, what's your typical protocol, and it's going to be like a benzodiazepine like Xanax, it may be some type of medication to get the blood pressure down, and then they send them home with like a psychologist or a psychiatrist referral so that they could then go get on an antidepressant. But instead, if I were in charge, if I saw slightly elevated blood pressure, something I thought the nutrients could handle, and there was a panic attack associated with it too. I'd say okay, well, here's your shot a passionflower motherboard. thenI Which I will call me down and simultaneously reduce blood pressure. And then hey, here's some extra magnesium. Here's some extra Foley. Here's some Hawthorne Berry, and we're good to go.

Dr. Justin Marchegiani: 100% I agree. I think those are all good things. People talk about 5G and being a driving factor. It's hard to say. I think the jury's still out on that. I think the first place you want to look for issues with 5g is you're going to see it in professional athletes, right? professional athletes are going to be in major cities playing, they're gonna be playing at the highest level, and they'll be being you'll be bathed in 5g just based on being in a in a local Metro City area, you're going to see decrease in athletic performance injuries. So look at the athletes first thing that'll be the first litmus test of a decrease in physiology and function.

Evan Brand: Yeah, and let me add this to that. t mobile and sprint and at&t and all these people part of their advertising as they speak about, hey, next time you come to such and such arena, we've equipped it with 5g so they're actually putting those small cell units on Around the actual arena for some reason, so I've seen that as a, as a promotional thing that those arenas are some of the first places actually to get the new technology. And then of course, it rolls out into major city hubs and then neighborhoods and then eventually suburbs and on and on.

Dr. Justin Marchegiani: Yeah, I mean, there's always been 4g for the longest time so there's going to be some of this stuff. My whole thing is you're probably not going to get away from most of it. So just get healthier. So the healthier you are, the better you'll be able to deal with it. My big concern is going to be like if you're got a 5g Tower right on top of your work office or a school that your kids and that's kind of my bigger concern because a lot of these technologies they're they're exponentially more harmful The closer you are so the closer you are to it. more detrimental so when you're when you're right on top of it, that's where I'm really concerned the most.

Evan Brand: Yeah, distance is your friend to I saw there was a couple of guys I don't know if this was an official study or just some, some testing they did out in the field. It was some guys out of New Zealand, I believe. They found that even just raindrops for example, reduce the 5g signals by over half over 50% reduction in signals just based on the rain. And they may have actually been researchers that were helping implement the rollout of this. They weren't necessarily anti 5g people, but they were just reporting, hey, look, when a rain shower comes, you're going to lose your signal. And potentially with some of the satellite stuff that's being done. What about cloud cover is in the clouds, because I've had family members that have had satellite TV or radio and they say, look on a really cloudy day your signal gets cut down. So I think there's a lot of variables and factors in this in the rollout might not go as smooth as planned, which if you think that it's going to affect you, that may be good if the rollout is failing, and these environmental issues like even the leaves, think about the seasonal changes when all the leaves Come on the trees. We know that was some I think it might have been the same guys who did the rain study. They showed that when you tried to blast that type of frequency because it's a higher frequency. It can't penetrate as deep so it couldn't penetrate through a tree that had full leaves on versus a tree that had no leaves. It could go Of course right through it. So just line of sight is very important when it comes to actually getting exposed to the so if you're kind of living in a Rolling Hill topography, unless you're on top of the hill and the towers on top of the hill with you, you're in much better shape. So yeah, I agree with you. It's tough. I mean, I think it'd be really cool if we could just go and point the finger and say this is it. It's this, but it's too difficult. I think it's going out on a limb right now.

Dr. Justin Marchegiani: Exactly. I don't think I mean, let's look at Italy. They're one of the country's hit the hardest. I think there's a lot of other natural, you know, I call it overcomes razor, right? more probable reasons why Italy got hit really hard. Right. So number one old old population, right 70, 75 plus lots of comorbidities that that's your biggest risk factor. Number two, they waited a very long time to close down their border and we know how the social distancing and the quarantine has been effective at decreasing the exposure, right. And then also, number three, they just have a lot of a lot of Chinese companies actually bought a lot of Italian brands, but a big name Italian, you know, clothing brands. And what they did is they basically ship all the Chinese people up there to work in that northern Italy town, producing those brands. And they did that to keep the Made in Italy tag on a lot of the products. So there's a lot I think over 500,000 Chinese citizens that are legal citizens up and up in that Italy area. So I think there's a lot of traffic going back and forth. That's probably the bigger variable that I think hit Italy. That outside of a variable of 5g that's probably more likely of all the different things that's that's happening there.

Evan Brand: That's a trip. That's very interesting. We got two more things we need to talk about before we wrap it up. One thing is exercise in generals, of course going to boost nitric oxide production. Yep, so like interval training you and I were kind of talking before we hit record about hit training. So high intensity interval training, maybe just a quick sprint followed by a walk or if you have a row machine a hard row or if you have a cycle machine, hard biking and then resting, those things are really really shown to to increase nitric oxide. Hey, go ahead. Yep, I was just gonna say Dr. Mercola had like a three minute nitric oxide video that he promoted where you were doing like a lot of arm exercises and just pretty intense stuff to boost it up. I think it'd be cool to try it and do a nitric oxide test strip on your tongue. That's one way to measure before and after. Probably not the bet the best or most accurate but that's pretty much what's available. There's not many good ways to test this right now to prove it. Besides feeling your hands if you got cold hands and feet, like I have and then you drink beet powder and then your hands warm up boom, there's your answer you increase nitric oxide.

Dr. Justin Marchegiani: Absolutely. also things like infrared sauna and or red light therapy can kind of modulate and help improve a nitric oxide as well. We've already chatted about citrulline citrulline is an amino acid that's a precursor that can be used to help improve nitric oxide and it can be used to bump arginine levels as well. And someone right wrote in on the message what about arginine and viruses. So yeah, there's some data on arginine, feeding herpes and such. I'm not sure if that's the case if you do citrulline because citrulline is a precursor. So your body may have some modulating mechanisms to prevent arginine from going too high to feed viruses. So I would if you're going to lean on it and you have a herpes issue, then you may want to just lean more on citrulline and then just work on a lot of the other things and just keep in mind that the deeper stuff like the thyroid hormone, gut function, pre diabetes and metabolic syndrome issues with high levels of insulin from high levels of blood sugar, you mentioned some of the exercise full body functional movements are going to be powerful. And then also just keeping inflammation levels under control. You know, keeping the gluten in there, the refined kind of junky dairy and a lot of the refined sugar and processed foods are going to keep inflammation because inflammation antagonizes nitric oxide, right? inflammation is going to increase, you know, you're going to have an increase in cytokines and interleukins and, and prostaglandins like prostaglandin, e two, and these things are going to cause more constriction, they're going to cause the the vasculature to kind of pinch down tight, and then we're going to have less oxygenation. So, in this time of coronavirus, being an issue, we really want to improve oxygenation. So these are strategies that we really want to make sure that we're hearing to on the diet side lifestyle, side and supplement side.

Evan Brand: Yeah, I don't want you to skip over it. That was an amazing paper that you found on the on the far infrared sauna therapy. So I'm just going to kind of quickly read off just a few more things that are in this paper here and then we'll and then we'll wrap it up. So there there is talk of improving into thelio function, peripheral blood circulation, increasing artery blood flow, alleviating fatigue and pain, reducing blood pressure, promoting capillary dilation. It also goes into heart disease. It goes into reducing cortisol and glucose. So they were saying here that far infrared therapy could help act as sort of an anti diabetes treatment, it really helps to reduce the blood glucose levels and cortisol overall, therefore improving the ability to respond to insulin, chronic chronic kidney disease. So let's just say we talked about the kidneys a little bit today, talks about here too, that the function of the kidneys improves with sauna. So I mean, this is just amazing. I'm not going to say the sauna secure for everything, but wow, what a great tool.

Dr. Justin Marchegiani: Yeah, essentially sweating. I mean, saunas going to do it a little bit deeper, because the near infrared is going to penetrate deeper into the body. So you're going to have a little bit more of that vaser dilating effects, but just getting good functional movements in getting some sweating, getting your body temperature up also is going to be helpful and then look deeper at the functional medicine principles, thyroid digestion, and, you know, look at potentially doing things like a lot of these vegetables and upping our In a lot of these things to help improve nitric oxide levels in the body.

Evan Brand: Absolutely. Well, let's wrap it up if you want to reach out clinically, Dr. J and I are available. His website is You can reach out worldwide we work, FaceTime, Skype, Zoom, phone, you know, we work virtually so we can send lab test to your door, you get those back to the lab, we review the results and then make a game plan to get you better. So that's, my website for me Evan is And please make sure you're subscribed. We look at our subscribers and we've got a lot of you that are subscribed, but there's a lot of people that just listen and are not subscribed. So what are you doing with your life, make sure you're here because we're trying to tie all the puzzle pieces together. We've covered the diabetes and blood sugar aspect of this thing. We've covered some of the immune support stuff, the cytokines stuff, and we were really trying to just build, build, build, stack it on, stack it on. So we're going to continue to do that. So thanks for your support, and we'll be in touch.

Dr. Justin Marchegiani: And just one last thing to kind of stack on there. I'll reference other podcasts on the topic, but we already highlighted mold as being a potential deeper issue and then potentially heavy metals as well. And again, I wouldn't recommend going after those right away. Unless you're in an active moldy home that then we try to fix that. But you want to work with a good practitioner to prioritize these things. Because there can be a lot of, let's say, rabbit holes that you can go down. And we always want to work on the order of operations, what's going to give us the best results for the least time and effort?

Evan Brand: Yeah, exactly. You don't want to get distracted and put all your money and effort into something that's not the biggest piece of the puzzle. So that's what we do. We try to analyze your case. Look at those puzzle pieces, arrange those in not only the correct order, but the order of importance of how big is it going to move the needle? So yeah, you're you're exactly right.

Dr. Justin Marchegiani: 100% anyone that has Corona or any other issues, put it down below want to know your comments. Any feedback that you guys have in regards to improving your nitric oxide levels are some of the strategies that we've already talked about and you've implemented want to hear your opinion and your thoughts down below. Really appreciate it. Hey Evan, it was great chatting with you, man. You have a great day.

Evan Brand: You too. Take care. 

Dr. Justin Marchegiani: Stay healthy. 

Evan Brand: All right, bye bye.

Dr. Justin Marchegiani: Bye.


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