Dr. J and Evan discuss the link between gut microbiome imbalances and autoimmune conditions, emphasizing the importance of gut health for overall immunity.
🦠 Gut microbiome influences autoimmune diseases, with 80% of the immune system in the gut.
🔬 Toll-like receptors in the gut act as guards, activating the immune system against invaders.
⚔️ An overactive immune system can lead to inflammation and collateral damage, like leaky gut.
🧬 Bacteria such as Klebsiella are linked to autoimmune conditions like ankylosing spondylitis.
👶 Autoimmune issues can manifest early, even in children, due to factors like gut flora imbalances.
💊 Antibiotic use can create dysbiosis, leading to increased risks of autoimmune diseases.
🌱 Functional medicine approaches can help restore gut health and reduce inflammation.
🌍 The gut microbiome is crucial for immune function, with significant roles in autoimmune disease development. This highlights the need for gut health awareness in overall wellness.
🛡️ Toll-like receptors are essential in immune defense; understanding their function can guide interventions to balance immune responses and reduce chronic inflammation.
🔄 Chronic inflammation from gut issues can lead to leaky gut syndrome, allowing harmful substances to enter the bloodstream, thereby triggering autoimmune responses.
🦠 Specific bacteria like Klebsiella and Proteus are associated with autoimmune diseases, indicating the need for targeted microbiome testing and treatment.
🚼 Autoimmune conditions can arise in childhood, stressing the importance of prenatal and early-life gut health management to prevent future health issues.
📉 Long-term antibiotic use can disrupt gut flora, making individuals more susceptible to autoimmune conditions, underscoring the importance of cautious antibiotic prescribing.
🧪 Functional medicine can effectively address the root causes of autoimmune conditions by restoring gut health, thus improving overall health and well-being.
Dr. Justin Marchegiani: Hey guys, it's Dr. Justin Marchegiani. Welcome to the Beyond Wellness Radio podcast. Feel free and head over to justinhealth. com. We have all of our podcast transcriptions there, as well as video series on different health topics ranging from thyroid to hormones, ketogenic diets, and gluten. While you're there, you can also schedule a consult with myself, Dr.
Dr. Justin Marchegiani: J, and or our colleagues and staff to help dive into any pressing health issues you really want to get to the root cause on. Again, if you enjoy the podcast, feel free and share the information with friends or family. Dr. Justin Marchegiani. And enjoy the show. Evan Brand we are live. Dr. J. here in the house with Evan Brand.
Dr. Justin Marchegiani: Evan, how we doing today, my friend? What's cooking?
Evan Brand: Evan Brand Hey, doing good. We're gonna be cooking some intestinal bacteria here. Talking about how this can be a big trigger for autoimmune issues. You walk around. Thank you for your time. Whether it's at church or the shopping mall, if anybody goes to those anymore because of Amazon, or maybe just a grocery store, right?
Evan Brand: And crippled people, people that are hunched over, people that clearly have issues with their joints, they're limping, they're, they seem like they're having trouble, or you just watch people trying to get out of their car in a parking lot, like we're in this epidemic of people that have chronic illness.
Evan Brand: Unfortunately, those people are not getting the proper help they need, and their GI doctor is not telling them that the bacteria in their gut could be driving their reactive arthritis, or maybe their ankylosing spondylitis, or their RA, or their other autoimmune conditions, so we're gonna try to break apart what's happening internally, and then how that could be treated.
Evan Brand: Leading to these multi system chronic inflammatory diseases.
Dr. Justin Marchegiani: Dr. Justin Marchegiani 100%. When you look at autoimmune issues, the microbiome plays a massive role, partly because 80 percent of the immune system is in the gut. Also, we have these toll like receptors in the gut, and these toll like receptors, they're the centurion guard for microbes, for food, for different endotoxin stressors, maybe for roundup or glyphosate or different chemicals coming in molds.
Dr. Justin Marchegiani: And so when these guards essentially see an invader they get ready, right? They're in a defensive attack mode. And that could mean they activate the immune system. They can activate things like nuclear factor kappa beta, they can activate other types of interleukins, and they can rev up your immune system.
Dr. Justin Marchegiani: And when your immune system is overactive, you can have inflammation part of the response. When you have. a war, it's very rare that there's no damage, right? Even if you're the guy that's winning the war, you're still dropping a lot of bombs and creating a lot of damage. That's happening with your gut and with your immune system.
Dr. Justin Marchegiani: And of course, as a collateral damage, some of these things you're going to have gut permeability, leaky gut, and this elevated zonulin protein as a byproduct, and that activates the immune system. And then part of What Evan was talking about is we have this autoimmune collateral damage that can happen where your immune system starts to go after invaders, it starts to see microbes in the gut as invaders, and these surface proteins on some of these microbes look similar to tissues in the body.
Dr. Justin Marchegiani: And then when the immune system starts attacking these tissues, you can have what's called autoimmune peripheral damage occur. So for instance, we were talking earlier in our kind of pre show here about Klebsiella. Klebsiella is a dysbiotic bacteria that we see commonly elevated on some of the stool testing that we do, some of the genetic stool testing, and we see Klebsiella is associated with ankylosing spondylitis.
Dr. Justin Marchegiani: You may see this HLA B27 blood marker come back as well, and ankylosing spondylitis is an autoimmune condition that attacks the SI joint, starts to create fusion at the superior part of the SI joint. And so that's not good because we want to make sure our hip and our iliac, And that's why joint move appropriately.
Dr. Justin Marchegiani: So we have good function and good movement. And so that's just one bacteria and one autoimmune condition from there. We can spiral out into other things such as RA as well. And even rheumatoid arthritis where other joints start to get attacked and then we can even connect into other types of irritable bowel diseases from there.
Dr. Justin Marchegiani: What are your thoughts, Evan? Evan Brand
Evan Brand: I want to just go right into this case study because I think this is helpful for people to see how this manifests. So this is a little girl, one and a half years old. So if people are thinking this is a rare problem or they're thinking this is something that only happens to people when they're 60 and beyond or something, no, this happens very early on.
Evan Brand: Maybe this is related to birth. Maybe there was a lack of probiotics at birth. Maybe there was, in this case, this little girl. Their family was surrounded by farmland and a lot of crops that were being sprayed. She had issues with bad breath. She got agitated very easily. The parents said that she was definitely whinier than normal.
Evan Brand: The mom lived in a moldy home while she was pregnant. There was a lot of skin issues. In her case, there was not a diagnosed autoimmune disease, because at a year and a half, there's just most of the doctors are not thinking autoimmune disease. But when you look at her stool her GI map You'll see that on page two right out of the gate.
Evan Brand: There was already an h pylori problem and People say well, how does this happen to me? Like where do these bacteria come from? And then how does this happen? H pylori is very contagious. So for example, let's say the mother had h pylori Maybe she shared a cup with The little girl got H.
Evan Brand: pylori that then weakened the gut barrier. And then when you get to the keystone, these good guys, in theory, if you have enough good bacteria, hopefully you could crowd out some of the bad guys and keep things at bay. But in her case, you can see that some of the keystone commensal bacteria were just too low.
Evan Brand: So then when we get down here to the overgrowth category, you can see that, for a year and a half, this is pretty messy. And there wasn't Klebsiella in her case, but there was Citrobacter creeping up and then Proteus was already up. And then a whole big mess of Staph and Strep and Pseudomonas, Morginella, etc.
Dr. Justin Marchegiani: Dr. Justin Marchegiani Yeah, especially when you look at some of these things. I don't mind some of the Bacillus being there because a lot of times that's more spore based and can help. But when you look at the Morginella, people see Oh the reference range says And then you're 1. 443. That's not bad.
Dr. Justin Marchegiani: Remember that's E to the three means how many zeros come after the decimal place, right? So you got to move the decimal place three times to the right. And so that means Morganella is 143 times higher than the reference range. That's a big deal. Or Pseudomonas 400 times higher, so people look at it and they just say, Oh it's only four and the reference range is one.
Dr. Justin Marchegiani: It's really 400 times, so it's easy to look at that and get a little bit, twisted with some of the standard deviation stuff.
Evan Brand: And on the, on, on what's called the white paper, this is basically like A geekier version of a handout to some of the stool testing we do, even the lab tells us here, like in healthy individuals, opportunistic pathogens should not present a problem if there's a healthy gastrointestinal barrier, if there's good levels of commensal bacteria and a strong immune defense.
Evan Brand: But, as you mentioned already, if the intestinal barrier is breached, these normally harmless opportunistic microbes now pass through the leaky barrier Creating a greater infection and greater illness. And so then that's when you get into trouble. That's where it starts to ramp up the risk of, as you mentioned, this whole like autoimmune molecular mimicry type issue, where now these bugs are triggering the autoimmune reaction.
Evan Brand: And we've seen this in kids too, where even five, six, seven years old, they're diagnosed with juvenile rheumatoid arthritis. 99 out of 100 of those stool tests, they're going to look messy. You're going to see issues with infection on those stool tests.
Dr. Justin Marchegiani: Exactly. So we talked about it. We'll talk about a couple bacteria.
Dr. Justin Marchegiani: We talked about Klebsiella and that's associated with Ankylosing spondylitis, right? And then but we also these bacteria a lot of times especially in the dysbiotic side are going to be gram negative So that means they have an outer cell wall So they have two cell walls. So I tell patients imagine it's like the moat You Think of Game of Thrones in a castle, right?
Dr. Justin Marchegiani: It's got a moat around the outside, that's the first cell wall, and then you have the castle wall, that's the second. With the moat, imagine there being alligators in the moat, or some kind of spikes or something, right? That's the outer cell wall is called lipopolysaccharide or an endotoxin layer, and that layer is actually toxic.
Dr. Justin Marchegiani: Puts a stress on the liver, and so you have a lot of bacteria. Literally producing endogenous toxins, endogenous meaning toxins from within, and that's putting stress on your liver. And then we may have, maybe add in some mycotoxins, whether it's acetaldehyde from fungus in the body from candida, or mycotoxins from the environment.
Dr. Justin Marchegiani: Now we have all these things that are activating our immune system. They're activating these toll like receptors. They're increasing zonulin, they're activating this nuclear factor kappa beta and FKB pathways that are just accelerating inflammation. So we have, let's say Klebsiella out of the gates and then let's say we add in some Prevotella.
Dr. Justin Marchegiani: Prevotella is going to be associated with RA issues, and so the likelihood now of your immune system starting to tag the bacteria and then go after other peripheral tissue in the body goes up. So the more inflammation we have, the more things start to become a problem. Now you can throw in some environmental molds.
Dr. Justin Marchegiani: Now we have immune system distress from within, from the food, from the bacteria. Now we're eating maybe a poor diet as well, that starts to accelerate it. Now we're starting to get stressed and we're not breaking down our food well, that starts to create more stress in the gut. Maybe we start to develop some atrophic gastritis, because the gut lining is getting very thin.
Dr. Justin Marchegiani: Now we're, maybe the antibiotics are creating we have an infection, right? And then we create more dysbiosis, or maybe a candida overgrowth from the antibiotic overuse as well. And then the mold from the environment is starting to get our immune system more sensitive. Now we're histamine sensitive, and now we're going down this mast cell path because now we're gonna be on all these mast cell drugs because our immune system is overactive due to environmental allergens coming in, creating histamine, as well as our gut bacteria creating histamine, whether it's privatella, klebsiella, or proteobacteria, because proteobacteria is also associated with histamine.
Dr. Justin Marchegiani: AS, irritable bowel disease like colitis, type 1 diabetes, and then you add in maybe some Clostridium. Again, Clostridium can increase IBD, increase colitis, increase Crohn's. You can see, we start to see like these kind of lab tests that Evan's showing on screen. I'll pull it up again. Oh that's good.
Dr. Justin Marchegiani: Yeah, I want to go into that too. I want to riff on that. Okay, cool. But you can see here that we're creating this kind of milieu of bacteria, inflammation, and then you have environmental toxins from the outside, and then you set the perfect storm with foods, antibiotics, and then we have crummy digestion because we're stressed and our sympathetic nervous system is in overdrive.
Dr. Justin Marchegiani: That's the path that we see a lot with patients coming into our office.
Evan Brand: Yeah, said. And here's the other path, the other way you can end up with reactive arthritis or some other autoimmune conditions like this is simply by a UTI. So this is crazy, but there's a couple pieces of literature right here.
Evan Brand: Reactive arthritis can be brought on by a urinary infection with Proteus, meaning, females listening, if you've battled a UTI. Let's say a recurrent UTI. Maybe you've already been treated by your gynecologist or, some other practitioners helped you maybe with herbal antibiotics or maybe you've done regular antibiotics for that.
Evan Brand: But these UTIs are now being shown to trigger reactive arthritis. And then you could throw in some of these other bugs that you and I've talked about for a decade now, which are parasites. So I had Giardia and I had Crypto years ago. I hope and don't think I had Reactive arthritis, but parasites are now shown to cause that as well.
Evan Brand: So we can look at the bacteria We can look at the parasites. This can all be done at home with a stool test and then also Crohn's disease you mentioned crohn's and klebsiella that's in the literature salmonella And the ankylosing the literature as well. So this stuff is out there. This is not just us talking about it.
Evan Brand: This is real, and we've seen this stuff reversed by fixing the bugs and getting the infections gone, including the parasites right here. A
Dr. Justin Marchegiani: hundred percent. Yeah, a hundred percent. I wanted to just show one thing here, because we talk about, it's like a spiral, right? One domino falls, the next falls, and then two more fall, and then three more fall, and it becomes this vicious cycle.
Dr. Justin Marchegiani: Cause then patients are now treating the symptoms of the damage and it becomes pretty stressful. Just for instance, I'll just pull one thing up. Okay, Evan talked about a UTI. What was the bacteria for the UTI? Evan Brand That was Proteus. Dr. Justin Marchegiani Proteus. So let's say you have a Proteus issue.
Dr. Justin Marchegiani: It starts to create a UTI. Guess what's gonna happen? You're probably gonna get some kind of a fluoroquinolone, right? Antibiotic, right? Whether it's Cipro, Amficillin, Ketamicin, right? These are different fluoroquinolone antibiotics. Guess what? These fluoroquinolones They can create mitochondrial toxicity.
Dr. Justin Marchegiani: There's more data and more studies on this. And if you're a guy, it can also go after your tendons and ligaments. So you have increased risk of Achilles tendon rupture. And so look, right here, although these oral antibiotics are approved by the U. S. FDA for treatment of urinary tract infections and sinusitis, they're commonly prescribed off label.
Dr. Justin Marchegiani: And then guess what? Serious safety concerns have been identified with Long term neuropsychiatric issues. So it's not even just neuropsychiatric. We also know here, guess what? It impacts the mitochondria. Guess what? The mitochondria is the powerhouse of your cells. It's how you generate ATP. So if you have chronic fatigue, or brain fog, or mood issues, I guarantee you energy, Right here, and your reactive oxygen species they're gonna lead to lipid damage as well.
Dr. Justin Marchegiani: Again, this is in vitro, but we know that this is a, like an older stu oh, 2013. So we know that over the last 10 years, there's way more studies on the fluoroquinolone vicious cycle that we're seeing here as well. Yeah, people call
Evan Brand: it getting floxed, right? I think they usually spell it F L O X E D.
Evan Brand: So I've had a lot of emails from people, it's Hey, I got floxed. Can you help me? And that just means that, yeah, they had UTI or they had some other issue. They got the fluoroquinolone family prescribed to them. They took it. Now, as you mentioned, they have tendon issues. They have RA or some other autoimmune joint condition and they're in bad shape.
Evan Brand: in a lot of cases.
Dr. Justin Marchegiani: Yeah. And this is where patients like that, we got to do good quality red light. We got to put good collagen on board. We have to do good things to get our reactive oxygen species down, whether it's nicotinamide, adenosine nAD tip, different types of products, or we're using, some kind of a peptide that's going to stimulate tissue healing, maybe orally or injecting.
Dr. Justin Marchegiani: So there's a lot of things we have to do when that kind of damage is created because that tissue it's a vascular, you don't get a lot of blood flow. So how do you drive nutrition to, you don't get blood flow, you got to use other functional medicine modalities for sure. Evan Brand
Evan Brand: Yeah.
Evan Brand: And this gets a little bit scary, but there are things we can do on the natural medicine side just to help people feel better. So we're saying, yes, we have to fix the infection. But there are different anti inflammatory products, herbs, nutrients, enzymes that we can use to give you relief while we're waiting.
Evan Brand: And a lot of times we'll do that. So for example, it could take sometimes a couple or a few weeks to get lab results back. So we'll often create this starter protocol where we can give you a set of nutrients, maybe that's black beans. It's on my podcast as well. It's been probably a few years, but I had a client who was a therapist and she had a what was diagnosed as psoriatic arthritis and her pain on a scale of one to ten was an eight or a nine And when she was a therapist that this was a brick and mortar practice So she said that she was in so much pain She was embarrassed to stand up because the pain she would like make a face to stand up to greet her You know clients when they come in the room So she would just sit there and just start waving to the patient coming in instead And then by the time we fixed all the gut bugs did other nutrients for the gut Her pain was gone, and she could put her pants on now without crying.
Evan Brand: That was her morning, was like crying, putting pants on. This stuff can be turned around significantly, and it doesn't have to be a life of, I don't know, what's a conventional approach gonna be? Like, ibuprofen and probably, what, steroids? What's a conventional approach gonna look like? It's not what we're doing.
Dr. Justin Marchegiani: Yeah, I had to pull a reference from my book, because I'm finishing the last round of editing, and there was One reference I needed to pull up for ibuprofen and I think it was the reference was 16, 800 people die a year taking ibuprofen for just rheumatoid, like diagnosed rheumatoid conditions.
Dr. Justin Marchegiani: What about the average person who hasn't seen an MD yet has chronic pain and it's just taking ibuprofen daily for a few months anyway, right? So these medications, no one really thinks of ibuprofen that you can get at Walgreens, for five bucks or something that is deadly. But it really is.
Dr. Justin Marchegiani: And these medications, they work great. If you bump your head and you need it for a day or two, it's fine. Just if you need it for weeks on end, you need to go see a functional medicine person to really work on getting to the root cause and or a good soft tissue person. If there's pain in the tissues and the joints, you may need a combination of both people in your corner helping you out.
Evan Brand: Yeah you know what's interesting about Klebsiella here in the literature is saying here that those with a history of long term antibiotic use are at risk. Here's the idea, right? You're eating a bunch of dairy, you get a sinus or an ear infection, like I had a contractor over my house the other day, this guy's so puffy in his face, you could just hear it and I'm like, dude, what's going on with you?
Evan Brand: Oh, major sinus infection, man, I'm getting antibiotics. Okay, so this guy, sinus infection, he eats dairy. He's definitely overweight. I know his diet is garbage. I've talked to him about it. Okay, so he's eating garbage. Now because he's eating garbage, he gets a sinus infection. He now gets the antibiotic.
Evan Brand: Here in the literature, it's showing that those with the antibiotic use are at an increased risk of Klebsiella. Now you get the Klebsiella overgrowth, then you get RA. Klebsiella Then you get put on the immunosuppressant or the anti inflammatory drug. You see how this thing goes boom, these steps just knock you down.
Evan Brand: Dr. Justin
Dr. Justin Marchegiani: Marchegiani Yeah, and this is, I see it all the time, right? If you guys are listening, justinhealth. com slash sinus flush. Sinus hyphen flush. That's a link to my video that I give all my patients that have any sinus issues. Start with that. Good clean RO, saline base, distilled clean water, packet of good healthy Dr.
Dr. Justin Marchegiani: Justin Marchegiani Saline, whether it's you know, I recommend the extra, the double, Neomed makes a double one that's really nice. A drop or two of betadine or providine, iodine, or you can sub it for a milliliter of silver. You can go either one on that, and flush out each sinus for 2 3 seconds. Use some Exclay or Resque before and after, cause that'll knock out any biotherms, cause a lot of these people, the bacteria, Whether it's fungus, mold, resistant staph from marcons or whatever, you gotta break down the biofilms.
Dr. Justin Marchegiani: So we're either taking some oral NAC, we're doing some x layer rescue with your six big herbs in there, parsley, patiarko, tea tree, oil of oregano, we're doing the spray, grapefruit, two sprays in each nose, we're flushing the cavity out, three seconds each nose, then we do another spray or two, And then I'll take that same saline and we're gonna gargle, spread it right in your mouth like it's a water bottle in the football field, squirt, gargle 15 seconds, spit it out, st cause it starts it.
Dr. Justin Marchegiani: Cause a lot of times this junk's running down the back of your throat, it's keeping your lymph nodes swollen. Do that two to three times a day and get your air filters checked as well or make sure you at least have it happen with a VOC. Start there. I can't tell you how much of this is a foundation and it's gonna save you being put on a Cipro antibiotic and creating lifelong mitochondrial issues too.
Evan Brand: And this is not, and yeah, said on all that. And this is not to brag. This is just a reality of when you take good care of yourself, you take good care of your kids, you have the proper diet, you have the proper nutrients and you're consistent with working on your gut health, keeping your air clean, like half my kids school has been out sick, like within the last three weeks, they've been sick.
Evan Brand: Half the school is just gone. You're talking like vomiting, flu, viral stuff, fevers, diarrhea, you name it. And knock on wood, my kids have been solid. My oldest missed one day because in terms of the timeline of her fever, it was like still within a 24 hour period where she couldn't get back in. So she was out one day.
Evan Brand: Luckily, it was just maybe a couple hours of a fever and that was it. And so I've worked really hard. You and I've talked about our journey for the last decade now. It's hard work. I'm not saying that this is so easy. It's hard. It's challenging. But even in the middle of the night, I could be up pumping this or pumping that, or to help these kids.
Evan Brand: And you really have to know that, health in the modern world, it is a marathon, it's not a sprint. So when you guys tune into this, we're not saying here's the miracle cure that you take once and you're good forever. No, you're still going to come in contact with all these pathogens.
Evan Brand: We're still, gonna be against all of these. It's just a matter of making us, the host, a healthier version. We're getting rid of toxins that are suppressing our immune system. There's a lot of kids at school that I can just see that the issues in their face, you'll see dark circles, you'll see rashes, you'll see like eczema stuff, kids are really struggling right now.
Dr. Justin Marchegiani: Dr. Justin Marchegiani Yep, 100%. And when we talk about these microbes aren't like a flu where you just catch it. There are definite microbes where you can get a significant bolus of a parasite or H. pylori or C. diff, and you can have very acute symptoms for sure.
Dr. Justin Marchegiani: But a lot of times it's a combination of opportunistic and opportunistic. Environmental issues, whether it's stress, inflammatory diet, antibiotics, lots of acellular carbs or processed sugar, right? And it's a combination of these things over time, increasing gut permeability, stimulating our toll like receptors in our centurion guards in our gut, activating the immune system, and then we get more exposed to environmental things in the environment, mold, or just, antigens out there in the air, whether it's like danders or pollens, and then your immune system becomes, just goes haywire, and then you're in, you're like this, on.
Dr. Justin Marchegiani: Singular or Zyrtec and you're just chronically in this environment that's stuck. And again, the gut is gonna be a big part of it. And when we talk about these microbes, these aren't things that you just caught like you caught a flu virus. It's gonna be something that's gonna be worked its way in there over time.
Dr. Justin Marchegiani: It involves sitting there with a functional medicine provider and really getting to the root and peeling back the onion as we get to the underlying cause.
Evan Brand: Yeah, said, and I think you alluded to this, but just to be clear, if you or your children or your loved one, if they are battling like histamine type issues, allergy type problems, keep in mind in the literature, it's known there's other bacteria that do this, but since we're on the category of autoimmune triggering bacteria Klebsiella.
Evan Brand: Causes histamine problems. So that bacteria is releasing histamine. So if you're eating avocado, pineapple, leftovers, whatever, if you're eating higher histamine foods, corn, and you have histamine producing bacteria in the gut, you see how quickly that histamine bucket overflows. Now you're on H1 blockers, H2 blockers.
Evan Brand: And maybe that's keeping you quote functional to where you can still do your life and drive your kids to school and back. But you're really not that healthy because you've got these gut bugs filling that bucket up.
Dr. Justin Marchegiani: Dr. Justin Marchegiani Yeah, exactly. And just just to give you guys a little list, maybe we'll put it up on screen with a little infographic.
Dr. Justin Marchegiani: But we have Prevotella is one bacteria that we see overgrown. associated with a lot of RA, rheumatoid issues. Then we have different things like a protease that we already talked about that's going to have connections with ankylosing spondylitis along with klebsiella and protease, ankylosing spondylitis, type 1 diabetes, and irritable bowel disease like Crohn's We have Clostridium difficile, or C.
Dr. Justin Marchegiani: diff, that's gonna be another ulcerative colitis or Crohn's type of condition. Bacterioides fragilis can be an MS type of issue, so that's continuously over, overrun. And then Fusobacterium, another one we see, RA, rheumatoid arthritis, and irritable bowel disease like colitis too. So those are our biggest associations.
Dr. Justin Marchegiani: We could throw maybe H. pylori on there, cause that's associated with gastric cancer, and atrophic gastritis, so that's another one that we see a lot on some of our tests. Anything you want to add, Evan?
Evan Brand: Just the gut bugs. Just make sure we're looking at the parasites too. Crypto. Because I had parasite. Yes, though.
Evan Brand: And it's right here in the literature too. It's saying that crypto could result in reactive arthritis. And it says here, aggressive cases could evolve into a reactive arthritis. I just encourage people, my advice, I'd say, once a year, get a good work up on yourself. Spend a little bit of money. I don't know.
Evan Brand: Maybe Disney world's fun, but maybe it's more fun to do a stool test. Like you're going to spend less money than you are at Disney buying a, what is it, probably 8 for a bottle of water and like 30 for a pizza or something. It's crazy. Come on. So I just, it's sad when I see kids suffering, especially at school too, like you'll hear these parents, Oh, we got back from Disney.
Evan Brand: And. And they spent prob I read one post on average, the average family spends 8, 000 for a week at Disney. And that's car housing, food, whatever, like tickets. It's God, you could have tested your entire family. And your grandma for that amount of money, but instead, that's not even
Dr. Justin Marchegiani: good food either.
Dr. Justin Marchegiani: It's not even
Evan Brand: good food. Yeah. But instead you got, cotton, candy, pretzels, nachos, cheese. I'm not saying don't make memories, folks, I'm saying have fun with your family. But my God, if you do these workups on yourself, you can feel so much better. I wanna have great mobility. I want have great energy, great sleep.
Evan Brand: I wanna have a good stress response. And I see so many parents especially, that are literally hanging on by a thread. And if their kids go down, they go down because they can't handle the sickness. We had a friend just this past week, kid got sick, freaks out, it gets too serious, goes to the doctor, boom, antibiotics.
Evan Brand: Here in the literature, we know these antibiotics can allow these other bugs to now come up. So what's going to be the relapse after that we have to deal with? So it's this game of whack a mole. And it's just not a good game to play. We really want to get you all healthy enough to where you can win this and not have to cautiously be pumping yourself full of something like an antibiotic to keep these bugs at bay and under control.
Dr. Justin Marchegiani: 100 percent Evan. It's really important. So you guys listen and you want to take the next step. You want to dive in deeper, you'll put links down below. You can reach out to Evan at evanbrand. com. See patients worldwide if you want that support, or myself, Dr. J at justinhealth. com. There'll be links there where you can click, reach out, schedule.
Dr. Justin Marchegiani: Again, we gave you guys some good information. If you're dealing with some of these chronic inflammatory issues, were you already on that path to having an autoimmune issue due to some chronic inflammation like the ulcerative colitis, the IBD, maybe it's Maybe it's some kind of MS, or maybe it's another type of autoimmune issue like the ankylosing spondylitis, the chronic joint issue, or it's RA, or psoriatic arthritis on your skin, right?
Dr. Justin Marchegiani: Whatever it is, there's a way that we can avoid jumping on the chronic steroid. The biologics, the things that are gonna overly suppress your immune system and set you up for other potential things down the road. There's some ways we can get to the root cause. Again, not saying those things aren't important, probably better off doing something if you're gonna, keep your diet and lifestyle where it at, where it is and crummy, but I think is a way that we can reverse it and get people educated and lock in a healthier diet and lifestyle for sure.
Evan Brand: Yeah. And the last thing I'll add to that is maybe you don't have a label yet. You threw out some labels that maybe people have already had.
Dr. Justin Marchegiani: Oh,
Evan Brand: good point. Yeah. There's so many that don't have a label and they have the fatigue. They have the joint stuff. They wake up stiff. They think it's normal for their hands to hurt when they make a fist.
Evan Brand: They, even turning the steering wheel in the car, opening a car door, carrying groceries, just some of these mobility things that we just attribute to getting up. Older and we just brush it off. Oh, my knees hurt. My mom said her knees hurt when I was this age. So I'm just getting older and we just, and there's a lot of people now that maybe have changed their mind on conventional medicine, but they're still not getting root cause.
Evan Brand: So they just live with this, subpathological level of disease and they just feel like crap and so then they just drink a couple beers on a Friday and call it good.
Dr. Justin Marchegiani: That's a really good point, Evan, because the average person is dealing with these chronic symptoms, whether it's on their skin, hair guts, joints, mood, cognitive, there's these symptoms are there for typically five to ten years, typically about a decade before they even get a label connected to it.
Dr. Justin Marchegiani: And then a lot of times that the medications that are recommended are palliative and they're not really getting to the root cause. And then a lot of times they're going to have their own host of side effects. For instance, Let's say prednisone is recommended. Now your chance for osteoporosis goes up, diabetes and blood sugar goes up, the chance of vascular issues to the eyes and other parts of the heart go up, right?
Dr. Justin Marchegiani: So you can see, you're just trading one, one over here for something else over there. So we really want to get to the root and try to have. low hanging fruit that literally has only side benefits, no side effects. Evan
Evan Brand: Brand I know. Isn't that interesting when clients ask that? You'll put a, you'll put together this amazing protocol what side effects should I expect?
Evan Brand: They're just coming from someone who's been on like five, ten medications. I'm like, side effects let me see. Maybe a little bit of bowel changes, okay, if we're killing bugs, but beyond that, feel better, sleep better, more energy, better sex drive, less bloating, like those are your side effects.
Evan Brand: Dr. Justin Marchegiani
Dr. Justin Marchegiani: Yeah. And a lot of times if someone's immune system's oversensitive, Cause they're immune systems all jacked up. Sometimes just going slow with everything can be helpful because any small change could be an issue. And so we always like to go slow with people that have a lot of these environmental sensitivities from mold and gut permeability.
Dr. Justin Marchegiani: And yeah, always set the foundation and then we move levers one at a time. Yep. I like that.
Evan Brand: Yep, and just to be clear, what are we trying to do here? We're trying to educate you all on the connection between your gut and your symptoms, and us as practitioners, we've helped thousands of people worldwide, so we encourage you to reach out so we can help you.
Evan Brand: We'll hold your hand for a little bit of time. We'll help get the proper data, because if you don't test, you've guessed, and we'll help with that data, and we'll help organize that and prioritize that for you. for you so that we can get you on your way to feel better and be more productive, make more money, be a better parent, whatever you want to do, it's important to fix these things because if you don't have your health, you don't have wealth in my opinion.
Evan Brand: So if you want to reach out drjustinhealth. com or me, Evan Brand, evanbrand. com, we'll look forward to seeing y'all again soon.
Dr. Justin Marchegiani: Some people were writing on the chat about what labs you recommend. Typically we like to make recommendations specific to the patient at a new patient console because there's a lot of labs that we have in our palette, if you will.
Dr. Justin Marchegiani: And we like to really make those recommendations more customized. So if someone's writing in, they're like, Hey, we want to work with you. We want to get a lab ahead of time. Typically wait till you get to see us at a new patient consult, and then we'll be able to make a more specific recommendation.
Dr. Justin Marchegiani: Dr.
Evan Brand: Justin Marchegiani All right. Take good care. We'll see you again soon. Evan Brand All right, guys. Take care. Have a great day. Bye, y'all.
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