Histamine Wreaks Havoc: The Surprising Hormone Connection with Estrogen and Thyroid | Podcast #453

In this deep dive, Dr. Justin Marchegiani unpacks how histamine—which usually helps with immune response and digestion—can spiral out of control and disrupt hormone balance, especially estrogen and thyroid function. He explains the roles of mast cells, basophils, and gut microbes in producing histamine, and how factors like estrogen dominance, chronic inflammation, gut dysbiosis, and environmental triggers (mold, humidity, allergens) fuel histamine overload. You’ll learn why the DAO enzyme is vital for breaking down histamine, how lifestyle habits (diet, alcohol, stress) and certain medications can inhibit DAO, and why this creates a vicious cycle of intolerance. Dr. J walks through diagnostic approaches and offers a holistic, root-cause strategy—covering diet, supplements, hormone balancing, gut healing, environmental remediation, and caution around long-term antihistamine use—to restore histamine and hormonal harmony.

Highlights
🧬 Estrogen–Histamine Feedback Loop: Excess estrogen stimulates mast cells to release more histamine, while histamine slows estrogen breakdown, driving estrogen dominance.
🌿 Inflammation & Gut Dysbiosis: Chronic gut imbalance and low-grade inflammation trigger persistent histamine release, keeping your immune system on edge.
🧪 DAO Enzyme Importance: Diamine oxidase is key for histamine clearance but is inhibited by alcohol, caffeine, gut inflammation, and certain drugs, perpetuating intolerance.
🏠 Environmental Triggers: Mold, high indoor humidity, pollen, and other allergens prime mast cells for histamine surges—remediation is essential.
💊 Antihistamine Caution: Over-reliance on pharmaceutical antihistamines can deplete nutrients and impair DAO, making long-term relief harder to achieve.
🌞 Thyroid Interference: High histamine impairs T4→T3 conversion and thyroid receptor sensitivity, worsening hypothyroid symptoms and further reducing DAO activity.
🧪 Functional Testing: Plasma histamine measures, DAO-activity assays, hormone panels, stool microbiome analysis, and mold testing pinpoint root causes and track progress.

[00:00:00] Hey guys, it's Dr. Justin Marjani. Welcome to the Beyond Wellness Radio podcast. Feel free and head over to justin health.com. We have all of our podcast transcriptions there, as well as video series on different health topics ranging from thyroid to hormones, ketogenic diets, and gluten. While you're there, you can also schedule a consult with myself, Dr.

J, and or our colleagues and staff to help dive into any pressing health issues you really wanna get to the root cause on. Again, if you enjoy the podcast, feel free and share the information with friends or family. And enjoy the show and we are live. It's Dr. J in the House with Evan Brand. Today we're gonna be talking about histamine and how histamine can impact estrogen and thyroid function.

We're gonna dive into this topic today. Again, if you have hormone issues, you do not wanna miss this topic, Evan. I'm in. How we doing, brother? Hey, doing great. We did a post about histamine and estrogen and it went pretty crazy. There were tons of people sharing this, and I was like, okay, this is hitting the needle on the head here for females because estrogen is stimulating your mass cells.

[00:01:00] And since COVID, there's been a massive increase in histamine issues, okay? There's no controversy around that. We just know that this has aggravated the immune system and this has aggravated the mast cells. But then. When you combine excess estrogen or estrogen dominance, which will break down, what's the difference?

What does that mean? That's gonna be negatively affecting your mast cells. Meaning your histamine bucket is already so full. If you go and eat high histamine foods or if you get exposed to allergens, that puts you over the edge and then you end up with all these wacky symptoms. Maybe your doctor or maybe your allergist puts you on a histamine blocker, but that's not root cause.

And we've got some better strategies that we're gonna chat about today. Yes. And also your immune cells can't produce histamine. And so one of the biggest stimulators of histamine production is inflammation, right? Your body will respond, your immune system will respond to inflammation. So for instance, just to give you kinda like a crude example, if I bump my elbow right, it swells up.

Why is it swelling up? It is swelling up because that [00:02:00] inflammatory physical input of my elbow against my desk, that creates inflammation. That inflammation then creates the cytokines and interleukins, which are chemical messengers that talk to the immune system. Your immune system then creates histamine as a means to vasodilate to increase nutrition, blood flow, oxygen and immune cells to clean up that damage.

And so that's great. We want histamine in this acute scenario. The problem is when inflammation goes from being acute to chronic, that's where we start to have problems. And so now we have this chronic low grade histamine because our immune system is overactive due to inflammation in our environment.

Inflammation in our gut via creating dysbiosis because of glyphosate or Roundup, which then knocks down beneficial microbes and that creates dysbiosis. Or it could be due to the fact that you've you've created inflammation via food allergies. Gluten dairy, processed sugar, that inflammation in your gut is chronic.[00:03:00]

And you also have these immune cells in your gut called basophils, right? So you have five kinds of immune cells. You have neutrophils, which are respond primarily to bacteria, lymphocytes, bacteria, and viruses. Eosinophils, parasites and chronic allergens in the environment, monocytes and basophils. And when basophils start to go from the bloodstream into the tissue, they become mast cells and mast cells produce histamine.

And so when we have that chronic low grade inflammation, we're gonna be producing. Histamine and then obviously certain gut microbes when they start to come up. Bad microbes, we're talking citrobacter, pseudomonas, Klebsiella, morgane, Proteus. When we have high levels of these microbes can also produce histamine.

They can be an endogenous supply of histamine. We haven't even got into exogenous things like. Mold or toxins in the environment, but let's just keep it on just general inflammation. 'cause most people we see there's this chronic low grade inflammation load. It's not the butt, my elbow [00:04:00] look, histamine's there to swell it up to provide blood flow, right?

It's this low grade chronic inflammation that we have to look at. Yeah, said. And the other mechanism too is that histamine is actually affecting the effectiveness of DAO. So diamine oxidase is what's, this is actually the enzyme that helps you break down histamine. And so the problem is you end up in this vicious cycle because you go and you have a glass of wine with your friends.

That's basically drinking liquid histamine. Alcohol's gonna block or inhibit DAO, so it's basically a double whammy. Then you have bacterial overgrowth because you did a dental procedure and you got a round of antibiotics, and maybe you didn't properly supplement probiotics. So now you have dysbiosis. We see that on your stool test, maybe you got exposed to mold and so you have a fungal infection or a candida overgrowths.

Also driving up histamine issues when I had mold, and I probably still have some in me. I'm still taking binders as we speak. Seven years later, I'm still taking them. And when I interviewed Dr. Nathan, he said pretty much binders for life because if you're not genetically detoxing well, you might as well just keep up with the [00:05:00] support.

So not to go on a tangent, but I'm still doing binders now for mold. But people that have had mold. It's this vicious combination. Okay? So you've got perimenopausal, you've got the menopausal shifts, you've got bacterial overgrowth, you've got going out for the girls for your mimosa orange juice. Yep.

Mega histamine. Yep. Alcohol, cirus, mega histamine. So this is how it spirals outta control. And then you have a chronic postnasal drip and you're like, okay, why? Why am I having this sinus problem? Why am I having this nasal drip? And then they go do a nasal spray. Maybe that helps, but ultimately this has to be fixed internally.

And then also we need to tie in the adrenals. Let's try to tie in the thyroid to this too. A hundred percent. So when we talk about DAL, that's the enzyme. Dian oxidase, excess caffeine, excess alcohol can inhibit it. Also healthy intestinal mucosa, so that intestinal mucosa that brush border in that small intestine that helps absorb nutrients.

If we have inflammation in that brush border and inflammation in that intestinal mucosa, [00:06:00] that's gonna significantly inhibit. DAO production. Now why is that gonna be inflamed? It can be inflamed 'cause of food, allergens. It can be inflamed because of potentially h pylori, low stomach acid sibo, bacterial overgrowth, right?

All those things can have an impact on that DAO production. And then of course, let's say we are on an acid blocking medication and we are not breaking down the food, right? That can increase it. Let's say we're on birth control pills. That can be a big thing. Let's say we're on SSRI medications, that can be a big thing.

Now also, let's say you're trying to do all these things, right? Let's say you have these issues and you're like, oh, I'm gonna follow like a western, a price diet, or I'm gonna start to eat more fermented foods. Now you're like, wait a minute. These things are making me feel even worse. Now I'm feeling dizzy.

I'm feeling brain foggy. Now I'm getting headaches. Why I'm eating fermented foods. Everyone in the natural medicine world says these are good things. It's a season for a reason, yes. But when this level of damage is there, or we have this level of endogenous [00:07:00] histamine 'cause of your gut bacteria or mucosal damage, it may be something that has to be cut out for a period of time.

Yeah. And how do you know if this is an issue? Because the DAO and the histamine test are not very good, in my opinion. The easiest way is two things. Number one, try. I'm not a fan of pharmaceuticals. Okay, so some would argue, just say, take a low dose Claritin. A clean, not die. Like a die free.

Okay. If you want to go a, just a Claritin route, try it and just see how your symptoms improve. My recommendation though, go on the natural medicine side, try the histamine support. I produce one that has some Perea leaf. It has Gucci, it has quercetin, it has NAC. If you try a histamine supplement and you feel better, there's your answer.

The second thing would be take DAO. In a supplement form before a high histamine meal. So for example, let's say you are gonna go out for mimosas and brunch and you're gonna get bacon, or you're gonna get a sausage, it's gonna be a higher histamine food, something with pork and spices in it. For example, if you were to take DAO [00:08:00] before that meal.

You eat the meal and then you feel fine, meaning you don't get brain fog, you don't get a rash, you don't break out, you don't get hot flashes or any weird symptoms, then you're probably onto something. And what I've noticed is over time, supplementing DAO, it almost allows your body to fill its reserves back up because I was on DAO for a while, maybe a couple of months, and then I stopped taking it and I kept my gains almost as if I was using DAO supplements as a backup generator to help me break down my histamine.

And then as I pulled the DAO out. I was fine. It's almost like my body was able to build up its reserves. I know that would be hard to prove, like what's happening with your reserve supplementing versus stopping. But for me, luckily, knock on wood, I don't need DAO anymore and I seem to be fine. But if I were to do leftovers, if I were to do alcohol, which I typically don't, I'd probably take some DAO, just in case a hundred percent.

So you have your medications, you have your H one and H two blockers. So your H one are gonna be primarily your allergy medic, your allergy medication. That's gonna be like your claratin. That's gonna be [00:09:00] your potentially Benadryl. Benadryl. It's gonna be more drowsy. So you wanna avoid that one.

That's gonna be your Zyrtec. Okay? And then you have your H two blocker, right? This is gonna be primarily your acid blocker. This is your Pepcid ac, this is your Zantac, right? So these are the ones you see this, it's common in the Asian population. They miss that enzyme to metabolize acid aldehyde, and so they'll do.

Pepd AC or an H two blocker. It's 'cause they call it the that glow you get. It's common in the Asian population 'cause of that genetic issue with histamine from alcohol and acid aldehyde. And so you can also, like Evan said, you can try the natural antihistamines. We formulate some that are gonna have some great ingredients, whether it's different natural de histamine, de granulators, stinging nettle, quercetin, bro Moline.

The kidney tissue, like you talked about, DAO enzyme. I think part of it is because organ meets. Let's say the ones that have high DAO, a lot of kidney, there's a lot of good nutrients in kidney glandular, and so you may be getting extra B vitamins, you may be getting some fat cellular vitamins, so it may just be you're getting a lot [00:10:00] more nutrients, not just the enzyme, but extra nutrients from the glandulars themselves, and then also just test it.

How do you do when you have a kombucha? How do you do when you have some caffeine? How do you do when you have some citrus or some age meats? Do you feel off? If you do and you pull it out and you feel better, that's a pretty good sign. And then, hey, you have the natural antihistamine, or even a pharmaceutical H one blocker.

How do you feel? Those are pretty good signs. And then go look at your gut, because people look at the histamine blocker or the histamine supplement as the solution. A lot of times it's getting the environment better and getting your gut environment better. That's gonna be the. Yeah, said. Someone in the comments here said that they had a MAs cell activation from the sun, which is true.

Sunlight can trigger mast cell activation. When I was at my worst, I definitely did react to the sun, but I also love the sun so much that I wasn't willing to give it up. So even in a Kentucky winter when it was 20 degrees. But clear skies. I had my shirt off and I would go out in the cold and let that sun hit my skin.

So I have seen in some people that have [00:11:00] Maslow issues, they do react to the sun. But overall I would say you, you almost just have to push through. Maybe just try some of these herbs we're talking about. Take a look at your gut, see if you've got mold, something that's making you more sensitive, because overall to me, the pros of the sun exposure outweigh the cons.

Yeah, and just do the early morning hours where there's very little uv. Just get out in the sun when you're under a four on the UV index. Just if you have an iPhone, you can go and just pull it up here. Now, this is what I do. Go right over to your iPhone, go to the weather app, okay? And then just look where you're at, and then scroll down and find that UV index.

So like right now it's almost 9:00 AM and we're at a one right now. Right here. So you can click it and then you can have the whole map. So it'll be six in the afternoon, but then it'll be, right now it's only at one. So one, two, or three. Just get your body used to it at those early hours and then just ratchet up that dose gently.

I know it sounds hilarious to think about a dose of sunshine, but it is true that you might just have to baby step your way. I'm to the point now where I can handle solar noon and I feel [00:12:00] fricking amazing. Mercola did a video about that years ago. He was talking about how. He'll try to actually get out.

Most people dermatologists of course say avoid solar noon, but he's out there when it's a UV nine, 10, or 11. He talks about how good he feels. I do think it feels good. I just try not to get burned. Yeah, you don't want to get burned. The problem with sun in the eighties and nineties and early two thousands, the sunscreen that was out, it blocked GVB.

Which is what makes you burn. But it didn't block A and C and so people weren't getting the burn, but they were still creating lots of collagen damage 'cause they weren't touching A and C. So normally Mother Nature would have b. Telling you, Hey, I'm getting burned. That would tell you to get out of the sun.

But when you get rid of the B and you don't have the burn feedback, now you overdo the A and C, and that's where you create lots of collagen skin damage. So now you have sunscreens that are gonna be more natural, that'll have better fast, and there better antioxidants and a full spectrum of A, B, and C. So now when you block B, you're also blocking A and C, so you're not getting the excess of damage.

So that's why you [00:13:00] see all these studies of oh. The more sunscreens people took, the more skin cancer. My theory on that is because people were blocking B and they were not blocking A and C, so they were getting excessive damage. And also back then you still have it. Now we won't go into the mainstream sunscreen brands that are bad, but you can, you're gonna see.

So chemical compounds that are cancer causing. And if you go to environmental wellness group or skin deep or skin cosmetic database, you will see the links and the cancer causing studies that cite them. And so you want one that's primarily more zinc based or titanium dioxide based. Those are much better than the.

Ate brace or a lot of these benzene sunscreen compounds not good for your skin in the long run. Yeah. We could do a whole show on that too, if you want, but yeah the long story short is if you are reacting to the sun, that definitely clues me into mast cells. There's probably some triggers, there's some hormonal pieces, there's some gut pieces, and.

To tie it all back to the estrogen. A lot of people may not show high on [00:14:00] estrogen if they were to run a Dutch profile, for example. But when we say high estrogen, a lot of times this is just in relativity to progesterone levels. And as you age, typically progesterone is gonna be decreasing, and that's why you're gonna have more anxiety, you're gonna have more irritability because progesterone is crashing.

Whereas when you're in your twenties, your progesterone is pretty high. We've looked at a lot of young teens and 20 somethings, and progesterone is definitely higher in the twenties. Than it is in the thirties to the forties, the fifties. And so as progesterone is decreasing, which by the way, progesterone stabilizes the mast cells.

So this is why it's amazing to get progesterone in. And actually I was doing that for a period of time and it helped me significantly. Like it definitely calmed down reactivity. It definitely improved sleep quality. So what's your experience with progesterone? What can you say about it? That's a great question.

Progesterone has antihistamine qualities to it, right? And it makes sense because progesterone is. And can convert to cortisol or corticosteroids. And so because of that, cortisol is anti-inflammatory. Now the problem is when you overdo cortisol, cortisol is also catabolic, so it can [00:15:00] break down tissue. So in the end, if you're given progesterone and you just wanna make sure you're not putting gasoline in the fire, it's if you get a fire in your house, you don't wanna throw gasoline in it, right?

You wanna put the fire out. And so for. Dealing with a female who has a lot of stress, a lot of inflammation, poor diets, lifestyle's, not great. Lots of nutrient issues. Lots of gut problems. Then we really wanna work on dialing that in first, and then that helps. And then if we add progesterone in, you have to look at why the progesterone's low.

'cause sometimes you have estrogen dominance. 'cause estrogen in and of itself can lower. Or should, can lower progesterone levels and can increase histamine sensitivity. And when we have high levels of estrogen because progesterone's dropping, why does progesterone drop? Because progesterone can convert downstream to cortisol.

So when you're stressed and you're inflamed, progesterone can drop due to the chronic inflammation in your diet and lifestyle. It's going down to deal with cortisol. And then why can estrogen that relationship? Even if estrogen does not go up, that [00:16:00] progesterone dropping skews that ratio so you can have estrogen dominance and not necessarily have high estrogen.

It's the progesterone dropping is of stress. Also, chronic stress can impact the HPT access or the HPG hypothalamic, pituitary adrenal gonadal access. And that feedback loop, that lh that talks to the ovaries to then make progesterone that can get dysregulated due to chronic stress. We also see it with the adrenal cortisol rhythm too.

And then we have a lot of estrogens in our environment, so high levels of estrogens can lower. Or lower histamine sensitivity can make us more sensitive to it. So now it can increase histamine. So if we have, let's say, estrogen coming in from pesticides, or let's say coming in from mold, because mold is estrogenic in a lot of terms, mold, estrogenic, or it can be plastics in the water, microplastics.

It can be plastics in our food, it can be excess soy or phytoestrogens. It could be all these different things that could be impacting us. And so we have our estrogens. We have the water, we have our pesticides, [00:17:00] potentially glyphosate, we have the mold. And so all these things can drive it. And and then if we have high levels of estrogen, right?

Estrogen can increase thyroid binding protein. And so if we increase thyroid binding protein, it can drop our free fraction of T four and T three. So this is how the hormones connect. So this high estrogen can cause. Increased histamine and also stress can lower that progesterone. So it's a double whammy.

We have one side we're having a strike on the high estrogen. The other side, the stress is lowering the progesterone, and then we increase that estrogen and that thyroid binding globulin, which then decreases our free. T four and our free T three are active thyroid hormone. That's the big connection there.

Yeah. Now let's hit symptoms. We didn't talk about symptoms much. I briefly alluded to rashing, flushing, itching. Yep. Post nasal drip. Also though the mood stuff, so anxiety, irritability, panic attacks, depression. Like any mood issues you gotta realize fatigue and brain fog, fatigue and brain fog, sleep issues, chronic [00:18:00] headaches.

And then obviously it could be your PMS issues, your heavy, painful periods. I mentioned the anxiety, headaches or migraines excess bloating, fluid retention. All these things could be connected. And this is so common too, and it's just because of all the exposures. If you are living clean, but you're still doing alcohol, I would advise at least four a month or two or three while we're fixing your gut, while we're working on detoxing mold, detoxing pesticides, all the things that we do in the practice.

I would say ditch alcohol if you can. It's just not worth it. I see. Sure. You'll see these random stories of somebody living to 120 eating cake and smoking cigars and all that. But like they grew up on food in the twenties and thirties. That was so nutrient. So nutrient dense, whereas today, I saw a paper on magnesium. We've lost 80% of the magnesium in the soil in the last 100 years. So even if you're eating organic, you're still likely mineral depleted and you just can't afford extra mineral depletion from the alcohol. So my advice, if you have a histamine problem, ditch it completely.

And I wonder how much the DAO enzyme 'cause that [00:19:00] enzyme to make it. Our body needs magnesium and vitamin C and we need B six and we need copper. And we know that those nutrients. Just, we've gotten more deficient in our soil and we know we talked about it last time. Half the population is low in magnesium.

So if you're low in magnesium, you definitely set yourself up for histamine sensitivity. Just that alone now you add in the mold stuff, like we haven't even gone into what if you live in a moldy home or what if you live in just a home without good air filtration and high humidity like that itself could set you up.

And so that's where you gotta look at everything. If you just go to the one-stop shop clinician who's oh, it's just this thing, it's like you're gonna potentially miss it. Yeah. Yeah. And your allergist, maybe they'll be able to help you with a pharmaceutical, but the problem is, I don't think we talked about it today.

We've hit it in the past. But the issue is that the medications do deplete and or block DAO production. And so you're actually digging yourself deeper in the hole by taking the histamine blocking medications. And so those would be something I would use in a very acute situation, only just to buy you a little bit of time while you're trying to find root.

Cause. I've seen too many people stuck on [00:20:00] antihistamine medication and when they try to get off of it, they have a lot of. I guess you could call it a flare or a relapse of their symptoms because they were basically blocking that signal. It was like ding-dong ditch. The drug was just like quieting the button, the alarm going off.

But then you take the med out and all of a sudden the immune system goes haywire. Yeah, some of those medications on the H one blocker side. Can cause lightheadedness, they can cause GI upsets. They can create some issues of dizziness or dry mouth. So it's possible. And some of the nutrient issues with those medications can be, some of your B vitamins can be some of the full weight.

And guess what? It also can deplete magnesium. We know magnesium's needed for DAO, so sometimes these medications almost create a dependency on it because you're depleting some of the nutrients you need to be able to process histamine appropriately, which sounds like a perfect lifetime pharmaceutical customer.

It's true. These are just facts. And so you have to look at the underlying cause. A lot of these medications, they were never created to be a forever situation. Hey, I have this issue. [00:21:00] Conventional medicine treats the symptoms. It's not getting to the root underlying cause. And you have to look at it and say, Hey, oh, this is fine.

As a step gap. I'm on vacation. I'm having this issue. Let's go on this medication while I work with a functional medicine person to get to the root cause. That's fine. We're not anti-medication. We're just ask the question, is this fixing the root cause or is this setting me up for more dependency? And it's okay if you use it as a step gap.

Just keep in mind, we wanna also get to the root cause. Yep. So the testing that you would want to do if you had these issues, if you just wanted to investigate these issues, we alluded to hormones. So that could be a saliva or a urine hormone test. Yep. Correct. It's mailed to your house. So we do this all over the world.

We have international distributors, so we can mail these kits to you. You mail those back. I don't really see blood testing being that helpful in this case. I'm gonna lean more on the urine and the stool testing to investigate the gut, candida, mold, bacterial infections, gut inflammation. What's your opinion about blood in this case?

Would you find it helpful or not really? So if I see someone's symptoms are present and I see that the triggers, certain [00:22:00] triggers are driving it, that's enough for me to know there's an issue. The only reason why you'd wanna do like a, histamine, like a 24 hour urine or a DAO is you wanna monitor it over time.

Someone's really bad and maybe you just wanna see it drop over time. So maybe they still have symptoms, but their histamine levels are getting lower and getting lower. And it's more of a monitoring thing. But it doesn't tell me the root cause. So that's where oh, let's say my backer's a thousand x.

Oh, we cut it down to 500 x or 20 x. That tells me we're moving better in the right direction. That's a root cause. The other tests are more just telling you the temperature of the situation. I Is the temperature getting better? That's all. Yeah. More from monitoring does not tell you root cause. Yeah.

If your doctor runs blood work on you and they're like, you look fine, but yet you have these issues that's just not the right test. It's really not the most appropriate test for this condition. You really need the microbiome data. And let's say you go to an allergist and they see a whole bunch of like ragweed and seeds and flowers and things like that.

That's an issue. I've never I've not, have not [00:23:00] come across a really good. Allergists be like, Hey, let's go look at getting you a really good high quality HEPA filter with an activated charcoal filter. Let's go test your air in the home. I don't really see that. A lot of times it's oh, let's go on these allergy shots, or let's go on these histamine blockers.

They very rarely work on cleaning out the environment, and I'd never seen them say, oh, let's look at the humidity too, because guess what? Humidity is the fertilizer that causes allergens to grow. You take allergens from outside, they get inside. From just, windows and doors being opened, guess what?

You have high humidity. They grow, they breed, and so you have to get humidity down and you have to get things filtered out. Yeah. I love the winters in Florida because we do get a dry period where we can have our door open to the screen room. It's gonna be 65 to 70 degrees, but the humidity's mid to high thirties and forties.

And then this time of year, which we're recording this in April, boom, it's here, man. It's juicy out there. Yeah. And you leave that [00:24:00] back door open for 10, 20 minutes. The other day I was looking at the Hygrometer boom. In 10, 20 minutes, 68% humidity in the house. Huge. Now, because I've got the air conditioning running because I've got the whole house dehumidifiers, it was, I was able to get it back down into the mid 50 within just a couple of hours.

But yeah, for your average person, which I've seen, even some people in my neighborhood, they love fresh air, so they leave their doors open all day. But I know they're not running dehumidifiers. They're having literal. 70 plus percent humidity in a house with drywall wood. If you're in a fully concrete house, then maybe, but in most concrete houses, I've been in concrete construction homes, they still do some wood framing and they still do drywall.

And so they do trim, they do baseboards, they do trim around your windows. And so like even a concrete home could still have wood and food for mold. I've had some people debate me about that. I live in x, y, Z country. We use concrete block homes down here yeah, but you still have food for mold in those [00:25:00] homes.

You have, yeah. Furniture, you have a wood headboard on your your bedroom. You've got a reclaimed wood, farmhouse headboard. It's not good. Exactly. Just go on the weather app on your iPhone, go down to humidity. So right now it's 49% humidity where I'm. Guess what, that's fine to open up the windows and doors, but also if you're really sensitive, I tell patients, do your mold plate testing test inside, and for an open it off for an hour or two.

Notate where it is, take it, but also take a random outside sample. If the inside's good and the outside's really high, guess what? We are not gonna keep the windows and doors open 'cause those allergens come in the house. And so you gotta look at how sensitive you are. Now, the same kind of molds that are outside aren't the same.

You may see micro spore or cladosporium. These are gonna be more soil-based molds or just the molds from decaying plant matter. But if you are sensitive, that could be an issue. You're not gonna get like a lot of the mycotoxin molds, like the cladosporium, I'm sorry, the fusarium or penicillium or aspergillus or stacky bots or Citron in, these are the mycotoxins from the mold as well.

And so you gotta look at the [00:26:00] outside too, if you're sensitive. Let's share this just for fun. Okay. Since you brought up your humidity, let's just show this map real quick. This is current, this is today's current relative humidity map. Will you bring that up? Yep. So some people that are like, okay, I live in the desert, I'm fine.

Yeah, like in Vegas I used to live out there 19%, so that's cool. You've got Western Arizona, you've got in the twenties and thirties, but look, even just Eastern Arizona, you've got up to 70 ish percent. Up in New Mexico you've got high moisture as well, and Colorado. Sure. Some people argue and you and I talk with.

With Jeff, who's a friend of ours who does mold investigation, and he'll say, look man, I'm in Colorado every single week for treating mold issues. So this idea that, oh, I live in Colorado, dry climate, look here at Colorado, you've got in the sixties, depending on where you're at. So moisture is.

Everywhere. You really can't escape it unless maybe you're in Vegas. But [00:27:00] I've even seen moldy homes in Vegas because guess what? They still have indoor plumbing. And so you have air conditionings that run all summer and the air conditioning's in the attic that leak and the pipes that condensate.

So it's if you had no indoor plumbing. No HVAC and you're in the desert. Maybe you're completely mold-free living in a tent, but otherwise you have potential risk. Yeah, I agree. So we have to look at the environment's really important to looking at things. I recommend for inside the house, look at relative humidity.

That's a pretty good place to be for outside dew points better because you're gonna keep your. Temperature inside, within five degrees or so all year round. Anywhere from the upper sixties to low seventies is gonna be where it's all the time outside. It can fluctuate. And so that's where Dew Point is.

Nice. So Dew Point, we like to be somewhere in the mid to low fifties is great. That's a good, idea. That factors in, the dew point is we're dew forms and so if it's 60 or 70 degrees and you're in the fifties, you're fine. It has to get to down into the fifties at that same level for there to be dew or moisture in the air.

So that's how I differentiate them. Dew point versus [00:28:00] relative humidity. Relative humidity, outside Dew point. Sorry, relative humidity inside Dew. Point outside. Yep. So get your labs done. We can help with stool, we can help with urine, we can investigate hormones if we need to. But typically two to three labs, you're gonna have an amazing workup and you're gonna have a lot of data just based on that.

And you can turn this thing around. And I know a lot of the women that listen to our show, they could be forties, fifties, sixties, they could be menopausal and they're curious about I've been like this for 20 years. Am I actually able to get better? We get that question a lot like I, is it too late for me?

And the answer is no. The answer is no. It's just that over time these issues do tend to compound because the bacteria are still there, the mold exposure is still there, the candida is still there. The nutrient deficiencies are accelerating and growing. So you can turn this around, but I would tell you not.

Don't wait until you hit rock bottom. You know how many people, and I know you're used to this too, how many people reach out to us and Hey, I listened to Dr. J and you for eight years. And now I'm just now reaching out. I'm like, why'd you wait eight years? We could have fixed you eight years ago.[00:29:00]

Yep. And you have to be holistic. When we look at everything, we're looking at the inside of the house, the environment. We're looking at the inside of your sinus cavity. You can go outside, have a bunch of mold, bring it back, and it just lives here. And then it just replicates. We're looking at your hormones.

Female hormones, thyroid hormones, and again, men you're intimately connected here too because you know how many men we see that are estrogen dominant, so men are just as connected. Even though we're talking about progesterone, estrogen with aromatase and insulin problems, men can be impacted too.

We're looking at the gut microbiome. We're looking at all the chemicals that could disrupt that. We're looking at digestion, we're looking at food allergens. We're looking at the whole nine yard stool testing, maybe even organic acids. 'cause what if you have colonized mold on some of the organic acid testing?

So it's good to look at all. It's good to have a lot of. Tools and a ways we can assess the temperature, so to speak. Yep. Yep. So if you need help, you can reach out clinically. We have international distributors as well, so if you need help internationally, I've done labs in South Africa, Australia, Canada, New Zealand, all across the uk, Latin America.

Totally. So it's really fun to help these [00:30:00] folks and. We can help you get to the bottom of it. Justin Health is the website for dr j Justin health.com, Evan Brand. I'm at evan brand.com and we'd love the opportunity to help. This is something that can affect kids too. A lot of times we're talking about adults because these issues have compounded over decades, but I have seen quite a lot of histamine issues, especially in young children that had exposure to antibiotics.

Kids that were C-section, sometimes we're gonna see it different. Dysbiosis issues and those kids, depending on like the after birth strategies kids that go to a moldy daycare, kids that have had mold exposure at school, for example, I've seen 3, 4, 5, 6 year olds with major skin issues.

And by fixing the gut, the skin gets better. So I don't really come in much with a topical skin solution. I just say, let's fix it internally. And the vast majority of time that works. A hundred percent agree. Yeah, I mean there are some good natural things we can do with skin, whether it's a witch, hazel based toner or some natural low, witch hazel cal even just some hypoallergenic kind [00:31:00] of moisturizers that can just provide moisture to the skin because the histamine can really deplete it.

So it's a lot of different things that you can do, but it's still gonna be palliative, not the root cause. And if you guys wanna reach out to Evan brand.com, again, we've been doing this guys for over a decade, 5,000 plus. Patience for me, probably 10,000 plus for both of us. So we have a lot of experience.

We'll put recommended links down and as a pin comment, so if you guys wanna see what we recommend and what we use personally, you can see that below. And feel free, share this with family, your friends. There's a lot of information in here that we'll, at least if you just take one thing out of the 10, it's gonna get you moving outta the right, outta the gates here and then start looking at your environment.

The environment plays a big role for healing with histamine. Yeah, you definitely want a good air filter. You definitely want a good dehumidifier that sets you up, right? And it's just once you get it, you just put it on and you're done. Even if your diet doesn't change, don't get me wrong, diet's everything, but if you have high humidity and a bunch of crap inside your home, that can be a big contributor to your histamine bucket, so to speak.

Let me show you, I bet you haven't seen this yet, but you. [00:32:00] Look how tiny. Oh yeah, those new ones. I seen those. That's Look how small, that's the, was it the IT or the atom, or what do they call that one? Yeah, the it. The it. Yeah. Isn't that cool? It's tiny. Cool. So I thought, why not, dude? It's literally like they just cut the regular, actually, you know what it looks like it's about the same size as the junior in regards to the dimensions, but then they just literally cut it off.

Yes. I just got it a couple days ago, so I'm gonna try it out. I saw that. Yeah. I got the big the big boy over in the corner there. I got one on each floor of my home. I know you're similar. Yeah, so awesome brother. Alright, good chatting with you guys. I love to see your comments down below. And again there's lots of stuff you can do.

So if you're disenfranchised, which just throw in the H one, H two blockers from your conventional medical doctor or your allergist, there's a lot of things you can do. So feel free to reach out down below guys@evanbrand.com or justin health.com for next steps. Alright guys, have a good day.

Bye-bye. Peace.