The Gut Connection With Urinary Tract infections (UTI) and Yeast Infections | Podcast #367

Urinary tract infections (UTIs) are a common medical problem affecting millions of people worldwide. The primary source for UTIs is presumed to be the gut. That’s why in this video, Dr. J and Evan talk about how gut bacteria can contaminate the urethral opening, eventually propagate themselves in the bladder, and cause symptoms of a UTI and possible yeast infection.

They also added that women are significantly more likely to get UTIs than men. It is due to anatomical differences that make it easier for disease-causing bacteria to travel to the urinary bladder after accidental transfer from the bowels. They also discuss the other clinical and evidence-based factors with helpful tests to find the root cause of these issues.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

0:00  – Introduction
1:53   – Urinary System
10:54 – Antimicrobials and probiotics
18:55 – UTI and Yeast Infection

Dr. Justin Marchegiani: Excited to be here with Evan Brand. Today, we are gonna be chatting all about the gut connection with urinary tract issues, UTIs and yeast infections. Really excited to dive into this topic. This is the common female topic that we deal with. I mean, men deal with UTIs as well but men have a longer urethra area so it’s harder for men to have UTIs with them. Women have a much shorter urethra so bacteria can make its way up to the urinary tract and blood much faster and easier and so probably more of a female issue but we’re gonna dive in. The physiology is similar between the two so men listening will still get something of it as well. Evan, how are we doing today?

Evan Brand: Hey, doing really well. And so, looks like about 90% of infection in the bladder, 90% of these cases of these infections of bladder, urethra and kidneys, it’s all related to E. coli, which of course E. coli are in your poop and can generally just take route up that way and they can migrate and populate within the urinary tract and so women obviously know these symptoms if they’ve had it but it’s you have to urinate more frequently, it’s painful urination. It could be pressure in the pubic area. It could be fatigue. It could go more severe into kidney injury but most women are usually so miserable before they get to that point that they end up doing some sort of conventional treatment. So, why don’t we just talk about the conventional approach because I think it’s great to highlight what people are doing and then what we’re doing differently that we may argue is a far more sustainable solution without the side effects. Antibiotics are gonna be huge and we’ve got some statistics on this. Antibiotics are prescribed for 33% of women to combat a UTI before the age of 24 but of course these synthetic antimicrobials are not without short- and long-term consequences.    

Dr. Justin Marchegiani: I’m gonna just share one thing here on screen just so everyone can see. So, you can see the female anatomy, right here is the urethra, here’s the bladder so you can see a very short distance from the urethra to the bladder. You can see here in the male anatomy, right at a much longer distance to get up here. Obviously in the urinary tract, you’re just typically with the UTI, it’s the bacteria that’s making its way up here, okay, into the urinary tract that’s causing the infection like Evan already mentioned that’s mostly gonna be bacteria, right?  Usually on the UTI side, it’s gonna be E. coli there, can be some Pseudomonas, it’s mostly E. coli. And so, it’s really easy for women to get bladder infection because you can see it goes up faster. Again, things like birth control pills we’ll talk about and antibiotics really shift the urinary pH and the intestinal pH which has a major effect on the bladder and the urinary tract and it makes it easier for bacteria to grow that tends to be why women are a little bit more susceptible than that for bladder infection obviously but in general you’re gonna see that with birth control pills because how estrogen affects the pH and then also women when they menstruate, right, just that whole vaginal area right there, sloughing off that endometrial lining. All that blood flow does shift that whole entire are to be way more alkaline because bloods around 7.3 pH so it does shift that whole vaginal tract to be more pH higher on the pH side which can increase other bacterial infections more on the vaginal side but hopefully that helps. Any comments on that, Evan?  

Evan Brand: Yeah. It’s totally interesting and this is stuff that maybe you didn’t pay attention to in school and biology class but now in adulthood it’s a lot more important and I think people just don’t even understand the anatomy of it and this is something that according to the research here, 25% of people treated for UTI, they will experience a recurrence 6 – 12 months later. So, I mean, that’s a quarter of these people that now have another UTI and they just go on this merry-go-round. And of course, every time you go on these antibiotics, you’re damaging the mitochondria, you’re damaging your gut microbiome in total, so it’s not just this one thing that you’re doing, it’s the sum to your system and it can really add up.   

Dr. Justin Marchegiani: Yeah, when we deal with urinary tract issues, I kind of look at, okay, you have yeast issues over here. They’re kind of, they intermingle right and how the different things happen. You have bacterial issues over here, right? So, your UTI issues are primarily bacterial, right, affecting the urinary tract. You can have BV, bacterial vaginosis, that’s another bacterial issue. Usually, Gardnerella bacteria is one that’s affecting the vaginal canal. So, a little bit different, right? Different, you know, same general area, different anatomy per se. You’re gonna have similar sequelae of tissues affecting it, right?  The big difference with the BV issue is you’re gonna get the potassium hydroxide odor which is, that’s kind of the fish smell. That’s what the bacteria in the vaginal canal does, it creates that potassium hydroxide that’s the fish odor. You’re not gonna quite get the odor with the UTI but you will have the burning during peeing. So, that’s gonna be the big differentiating factor. Sometimes, more odor on the BV but sometimes you can have none and then of course more pain during urination on the urinary tract issue and then if that continues to be left up that bacteria will eventually continue to go north and eventually hit the bladder as you can see that anatomy pretty short on video here. But, one of the big common issues is I would say like the big three, anytime I look at this problem, they tend to be the same. It’s gonna be a combination of antibiotic use so we’re wiping out a lot of the good flora in our intestinal tract which also affects the vaginal or urinary microbiome and then that affects the beneficial probiotics that actually make hydrogen peroxide like probiotics usually make hydrogen peroxide which is antibacterial. They’ll make different acids, glucuronic acid, they’ll make acidic acid. Different acid acids that actually help keep the microbes in check. They make hydrogen peroxide H202 and it keeps a lot of the bad bugs down. So, the first thing is we have a wiping out of the beneficial flora that also drive yeast overgrowth too so the same thing where it wipes out the good stuff, the beneficial probioflora, the probiotics the Bifidobacter, the Lactobacillus. The different species within the Bifidobacter and Lactobacillus, right? There’s Rudaea, casei, plantarum, lactis, these are all beneficial species, okay, that keeps the bacteria in check but also when you knock down a lot of the good stuff that can also causes this rebound overgrowth and yeast and that’s a lot of doctors today even on the conventional side tend to give an antifungal after an antibiotic in a lot of these female patients because they see a lot of these symptoms happen frequently. 

Evan Brand: Wow. And, you’re mentioning the antibiotic that starts this whole cascade and that’s not necessarily the antibiotic to treat an existing UTI and then we’re talking about these recurring UTIs. We’re talking antibiotics for something simple like, I’ve heard of some women going in for a dental cleaning or something just that seems benign and then boom the antibiotic just really had forced them to take another fork in the road with their gut health and of course the vaginal health is affected. 

Dr. Justin Marchegiani: Exactly. Now, with urinary tract issues, I mean they’re simple things, right? Sometimes, just after intercourse, after sex, just not peeing. Sometimes that sperm and the semen being up there can kind of create some issues with bacteria so urinating after sex can be very helpful. You’ll see it with younger kids just wiping the wrong direction, right, essentially wiping back to front bringing some of the bacteria in the stool into that urinary vaginal area can be a problem. Sometimes different contraceptive methods like that involve, like a spermicidal intravaginally can sometimes mess up the milieu of flora in the vaginal tract. Having bladder stones or kidney issues can sometimes have problems, going in for a surgical procedure where they put in some of a catheter, you know, those are, you know, gonna be way unlikely but you know just kind of given the gamut of those across the board. And then of course, you know, the antibiotic exposure and I would even say just too much sugar, too much carbohydrate, a lot of bacteria like acellular easy to digest refined processed carbs. So, more carbohydrates, more sugar, more grains, more flours are definitely gonna work, you know, increase those microbes’ kind of having a feeding frenzy if you will.   

Evan Brand: And, how can you find this out? Well, there’s an easy to do at home test that you can buy for less than 10 bucks. You can do these test strips at home. These urinary test strips and if generally, you see a dark purple, you’ve got a big issue and so it’s something that people should have on hand if you’ve suffered for a while. I know a lot of women; they just hate having to go to the doctor’s office and get tested and then they leave with another antibiotic and then they’re on this merry-go-round. So, we talked about the conventional approach, they really as far as it goes antibiotics 

Dr. Justin Marchegiani: So, with the test strips, I think most of them are primarily looking at either immune cell in the urinary tract. I think, a lot of times with yeast or bacteria. They’re looking for, like leukocytes or leukocyte esterase, they’re looking for bacteria or I’m sorry immune cells in there. I know, some of the yeast ones are looking at pH so they’re looking at a more alkaline type of pH. The more alkaline the pH moves from six to seven to neutral, right, neutral is around 7. Into the 7-ish range, that tends to say that okay we have more yeast issues or we’re starting to move back in the direction of bacteria if we’re starting to see some of these leukocytes moving into the urinary tract. 

Evan Brand: Yes. It’s kind of an indirect marker, right? You’re looking at those leukocytes and that’s what you would be seeing in terms of like, the light purple, dark purple, extreme purple on the test strips.  

Dr. Justin Marchegiani: Yeah. So, they’re looking at the immune system starting to come in there and obviously with a BV issue, bacterial vaginosis. They probably need a swab to see what’s going on there, see if it’s like a Gardnerella or a Pseudomonas or Klebsiella, you know, what the bacterial species is. Now, typically with yeast issues in the urinary tract, I’m sorry with, uh, yeast infections primarily gonna be Candida or Candida subspecies. With BV, it’s primarily Gardnerella and with UTI’s it’s gonna be E. coli, typically.    

Evan Brand: Now here is the cool part. Are you ready to talk about some of the transitions you hit on the diet piece of a bit of sugar process things? Maybe we should hit this first and then we’ll talk about, like, the functional strategies that kind of thing. You and I were talking about this before we hit the record that so many people, they want the solution to an issue like this but they haven’t even got the foundation styled in, in regards to their sleep, in regards to stress, proper hydration, nutrient density, lack of antibiotics if possible. Just those foundational pieces, a lot of times, are gonna keep women in a place where they’re not gonna end up with this problem so if you’re just tuning in, somehow you found us and you’ve not been listening for a while and you’re just now hearing us and you’re looking for this magic remedy, you got to make sure you get the foundations in order first because in theory, this should not happen if you’ve got the foundation style then.  

Dr. Justin Marchegiani: Correct and so first thing out of the gates is just foundational things like hydrating enough because if you have a UTI issue just having constant good water flow and also you know with some electrolytes in the water that can be very helpful kind of having an antibacterial effect. And just keeping that good water flowing, the solution to pollution is dilution so that can really kind of keeping things flushed down. Obviously, being very careful if you’re having antibiotics. Why did you have the antibiotics? Was it for routine preventative things? Was your diet off and your immune system’s weak and you got sick and you needed it? Why, right? So, you want to look at that and if you had chronic antibiotic use, you know, what does the bacteria in your gut look like because odds are, if your bacteria or yeast imbalances are present in the vaginal tract or the urinary tract, you probably, also have issues in the digestive tract. You may have SIBO, you may have bloating, you may have gas, you may have poor digestion, low enzymes, low acids, H. pylori, parasite infection, you may have to look deeper in the intestinal tract and actually work on knocking down some of those microbes fixing the gut and then really work on repopulating some of the good bacteria after the fact to really work on fixing the gut because you start to fix the gut pH and the gut bacterial milieu that does help improve IgA levels and that does help with the immune system in the vaginal area as well. 

Evan Brand: Yeah. Well said. So, if you’re coming in with the UTI, most of the time, there’s gonna be more than just a UTI present. There could be as you mentioned a number of, we have someone coming in and UTI or recurrent UTI is one of their complaints, I can tell you, you and I are gonna wanna run the stool panel and we’re gonna run organic acids because we’re gonna want to look at the whole microbiome and certain things may get missed on the stool and the urine should feel in the gaps like we might find Candida in the urine and it got missed in the stool. So, stool and urine, there are things that your typical doctor and your lab locally is not gonna run. They might run a urine panel but this is not the same urine panel as an organic acid, we’re talking something far more advanced, far more comprehensive whereas the urine panel, locally, is primarily just gonna look for bacteria or maybe leukocytes as you mentioned you might get a positive or a trace or something like that but it’s not a detailed description of what’s going on you mentioned several bacteria too, like Klebsiella and Prevotella, we can identify this on a stool panel. So, that’s why it’s so important to get the data and could we just throw a woman on an herbal UT formula, we could but you know, we want to do our due diligence, we want to do a good work-up on these people too to make sure that we’re not just cut straight to the chase and we skip something huge that we would find on these tests.  

Dr. Justin Marchegiani: Right. I mean a lot of the antibiotics they’re gonna be using are gonna be like Bactrim or any of these kinds of, um, Mors, Augmentin’s a big one. Bactrim and Augmentin, those are a couple definitely be very wary of any of the fluoroquinolone families because they have significant side effects regarding tensing tendons and ligaments and mitochondria so be really careful of using fluoroquinolones. Of course, when we work these patients up, we’re doing a really good history so we understand how everything came to fruition regarding the UTI, yeast infection or bacterial vaginosis. We’re trying to understand it, right? Obviously, with certain things like yeast infections, BV, like making sure things are dry in that area. If you’re in a very moist environment keeping things dry helps because yeast and mold love a very moist environment. So, keeping things dry tends to be very helpful. Soaping up some of those areas you’d be very helpful too that you can use a really nice, um, as long as the mucosa is not like really, um, irritable, you can really use a really nice sulfur soap especially in the outside air if there’s anything yeasty on the outside are, anything internally. There are definitely internal things that we can do. So, on the internal side, just getting water in there, maybe helpful using raw cranberry juice, not anything with added sugar but raw organic cranberries, you know, 4 ounces at a time diluted some water is pretty good. You can drink that. That’s gonna have a nice low pH in it, which helps prevent the bacteria from growing. It also helps with some D-mannose in the cranberries. Can also internally do things like different berberines, can be very helpful, that’s excellent boric acids, another excellent compound. You gotta be careful with these by, enlarged by itself because they can be a little bit irritating so you want some nice things that provide some moisture whether it’s aloe or shea butter. There’s different, like moisture compounds that can provide the moisture so you don’t dry out that tissue as well. 

Evan Brand: You know, how about some of the suppositories. Have you used those before? I’ve seen some of these like pH suppositories, those have been helpful, also I think it’s integrative, I know Aviva Romm did a talk or an article on it one time. There was a specific probiotic that we had used, I think, it was called pro-flora that we had used, uh, that was supposed to be inserted vaginally and that was like a game changer for BV and some other related issues. So, not only taking oral probiotics but vaginal probiotics as well. That has been a game changer for many women. It’s not something we have to go to a lot but it is a good tool if someone just in bad shape and the conventional strategies failed them or made them worse then something like these vaginal probiotics are helpful. So just to be clear, there’s some strains specifically for vaginal health that are taken orally but then there’s also other blends that you can insert vaginally and the women have reported great success with those. 

Dr. Justin Marchegiani: Yeah. You want to make sure the hydration is there, whether it’s aloe or beeswax or shea butter or coconut oil, some of those can be helpful. Again, the antimicrobials that we may use would be the boric acid, some of the neem, some of the different berberines. And again, we may want to also add probiotics in and around there that can be very helpful. In regards to, like yeast issues or, um, UTI issues, you got to be very careful because when you women menstruate, well more with yeast and more bacterial vaginosis because that’s affecting the vaginal canal more. When women menstruate, that blood is like 7.3, right? So, that’s very neutral to alkaline. So, when you’re menstruating, you’re taking that acidic pH in the vaginal tract and you’re moving it backup to a more neutral pH when you menstruate so that’s gonna actually make it easier for bacteria and potential yeast to grow and you could have a BV issue or yeast issue that can happen due to your menstruation. So, when you’re already more susceptible in that vaginal area, you know, you gotta, you may actually wanna do a suppository in and around your period too, because that pH is gonna move up and that can start to cause microbes to grow. Some women have to be more careful with that, you know, if they have a chronic yeast or bacterial issue just to make sure it doesn’t come back. 

Evan Brand: I want to hit a few more herbs and then I want you to riff on the birth control conversation because I think that’s huge. So, you mentioned berberine and some of the other related herbs. Also, we’ll use the antifungals at the same time. So, you and I have our own custom blends that we use and so we may use something like Pau D’arco, French tarragon, horse tail, olive leaf, things that have antifungal and antimicrobial properties. So, that’s the cool thing about what we do is as you mentioned Backstrom or some of these other conventional strategies. It’s just a big sledgehammer, right? It’s not a targeted tool. It’s one sledgehammer. We don’t know exactly what we’re gonna kill but it’s an antibiotic, were just gonna drop the nuclear bomb into your gut and we’re gonna disturb not only your gut microbiome, we’re gonna negatively affect the production of your nutrients in your gut. We’re gonna negatively affect your mitochondria. We may knock out the UTI but as you saw in the papers, 25% of those UTIs are gonna come back within 6 months to a year and so when we’re coming in with these antimicrobial herbs, also, throwing in antifungal herbs, that’s where the magic really happens because there could be a combination as we talked about. It’s rare to see just UTI, it could be a combination issue meaning there’s some Candida, there’s some bacterial problems, maybe there’s parasites in the gut too. Maybe there’s H. pylori like you mentioned. And so, that’s the fun part is when you take a blend and you’re working people through this protocol. You’re now knocking 4,5,6 issues out all at once in one fell swoop when they originally just came in with the complaint of UTI. When you do the labs, you wanna uncover so much more and that’s where the beauty is. 

Dr. Justin Marchegiani: 100%. Here’s one study here looking at the perceptions using contraception birth control pills. So, usually this is like a synthetic estrogen mostly, right, an ethanol, estradiol. I’m looking at the influence on the vaginal microbiota and so really the take home here inside of the gate, the vaginal state was significantly modified hormone administration apparently corrected the alterations uh, but has the potential of being an accurate tool. Where is it? Right here, um, there it is, I’m sorry. Statistically significant association between, this is, um, this is contraception and normal microbiota was observed after three months when the vaginal microbiome was modified at 6 months inflammatory reaction was detected in almost half of the women. So, only seven women but you can, it created an inflammatory state in the vaginal microbiota and then also yeast colonization was increased and it created an inflammatory reaction in three out of seven women and it altered some of the beneficial bacteria in the vaginal area. Now, small study but you can see, you know, three out of seven, it affected this and this is what we see clinically with a lot of our female patients is some of these things can be affected because it’s affecting: one, it’s creation; two, it’s causing yeast to grow impacting some of the good bacteria and how does it do this, it does it mostly via LDH. If you alter someone’s digestive pH, right, let’s say you give them a proton pump inhibitor, you’re gonna have all kinds of digestive issues and maybe even nutrient deficiencies that can affect things long term. Obviously, with birth control pills, there’s other things they do, they can create issues with nutrient absorption or they can cause nutrient deficiencies in areas of B vitamins, folate and also calcium and magnesium. So, we see a lot of women that do birth control pills have a lot of those nutrient problems. So, if you’re on a birth control pill, ideally, it’s better to use something that’s more barrier based or if you want to set it and forget it method, you know, potentially looking at the ParaGard which is a copper IUD, you just have to make sure you can handle the copper. I find if you want to set it or forget that the copper tends to be better than the hormones but ideally, you know, a barrier method it’s not internal all the time. It’s probably better so that just kind of gives you a couple options there. 

Evan Brand: Yeah. I’ve heard some stories, some horror stories about the copper ones too. So, like you said it cold be a problem but

Dr. Justin Marchegiani: Not everyone has problems with it. I mean, women that like tend to cramp a lot, they could have, because that cramping, IUD being in that uterus sometimes that can cause pain but it just depends kind of where women are, you know. Some parents may be pushing kids to have a method because they don’t want their kid getting pregnant and maybe they feel like they aren’t responsible enough at maybe 18 or 19 and they set it and forget it method. If you want that, I would recommend doing the ParaGard before you go to a hormonal method. 

Evan Brand: Yeah, for sure. And, not to mention too we’re already in a society of so much estrogen dominance and you and I have done podcasts about the impact of gut imbalances in issues with the glucuronidation pathway which is then causing further issues. So, we could see this estrogen problem in a woman who’s not on birth control. You could still see that manifest in this way and so that’s why you’re getting off of the xenoestrogen, you’re cleaning up your makeup. You’re getting rid of plastics. You’re fixing your gut. You’re improving detoxification. All these other functional medicine strategies are directly impacting your ability to beat this situation. So, we know, we always want people to look at the big picture. Don’t just look for the magic, uh, like, berberine, Pau D’ Arco remedy. And there’s a question here in the chat, ‘how many Pau d’ Arco capsules is needed for someone who has Candida in their gut?’. I have no clue because we rarely use it in isolation. We’re always gonna use it in a blend. And I doubt you have just Candida. You’ve probably got other issues too. 

Dr. Justin Marchegiani: Yeah. Somewhere when they come in, they could have a combination of a little bit of a bacterial, a yeast issue, UTI thing. That could be a kind of combination of 2 or 3 different things happening. This one may be more predominant. So, we never wanna just go all in on one thing. Again, if someone’s having vaginal issues specifically, there’s gonna be things that we insert intravaginally like some of the boric acid, like some of the neem or the berberines and we’ll probably interchange in some probiotics because part of the big problem is you have to get the bacteria flora in the vaginal area, back up to where it should be because it’s the good bacteria that will help keep the other bad bugs in check through their natural acid and hydrogen peroxide production. 

Evan Brand: Well said. 

And so, the point I was making is that I don’t want people listening and going okay just give me the freaking remedy. What’s the natural urinary tract remedy? That’s what I’m here for. And we’ve talked about some of those, you know, the mannose, the cranberry, the berberines, the Pau d’ Arcos, the French Tarragon, this whole blend, you know, that may be the solution but what got you here is important. Have you fixed the other issues that have gotten you here. And so, I hope people see the big picture. Sometimes, you and I are happy to just go boom, hit the oregano oil and were happy to just throw out just this natural solution but like you said before we hit the record, you don’t want people skipping out on the low hanging fruit. 

Dr. Justin Marchegiani: Exactly. And so, it’s always good to do history. I find the big issue is antibiotics can be a big factor. I also find just some of the low-hanging fruit like the intercourse and hydration can also be a big factor as well. You’ll be surprised. And so, my wife comes to me, she’s like, ‘my friend has this issue, what should I recommend?’. Well, it’s hard, I can’t really recommend a lot of things because I don’t know much about them if eating like crap and they’re not hydrating and they’re drinking lots of soda and they’ve been on lots of antibiotics, you know, I may say, hey, all right, do this [24:34] but that’s gonna be palliative and not fix the whole lead up and how everything went down. And so, the lead up and I call it the timeline history of how we get to this point matters so much because, you know, if not, you were just becoming naturopathic doctors that are using nutrients and herbs like MDs use drugs. Now, again, I think that’s better because a lot of these things are natural, have less side effects but still we want to be holistic and still root cause. 

Evan Brand: Yeah. Well said.  That’s the problem. There’s a difference between naturopathic approach to this issue and functional medicine approach to this issue. So, I think you made that clear, which is, you go to the naturopath, it’s hey, here’s the oversee, functional medicine is gonna come in and say, ‘okay, well, how did you get to the UTI?’. Oh, you took antibiotics, you’re on birth control for 20 years, you had a sexual partner who had extremely poor microbiome health, maybe there was some issue there, maybe you had multiple partners, maybe one of them had H. pylori. You have low stomach acid. You ended up with dysbiosis, then you got Candida overgrowth, then you drank too much alcohol, you loved to do wine in the evenings. You ate a little too much chocolate, you know, it’s like, that’s the more investigative route and that’s where people need to be thinking.  We’ve got friends that are naturopaths, good people, but you just got to go deeper most of the time.  

Dr. Justin Marchegiani: Yeah, and a lot of times too, if I’m, if someone has chronic issues, I wanna know more about their gut because the microbiome has such an impact especially with IgA and with the overall immune system. So, if there’s chronic issues in the vaginal area, you have to look up to the intestinal tract. Very important. 

Evan Brand: Yeah, and you would say there’s gotta be some link between the low secretory IgA that you and I are seeing on the stool test and what’s going on with the vaginal microbiome too, right? You would assume that’s a system-wide defense shield that’s gonna be affected.  

Dr. Justin Marchegiani: Yeah. It’s part of the mucous membrane barrier. So, mucous membranes in the eyes, the mouth, the intestinal tract, the urinary tract, the vaginal canal. So, if we see low IgA issues in the intestinal tract, that barrier is a little bit weaker. Think of the force field, you know, you see star trek, they put, like their force field up, right, so they, so when the Klingons go to shoot them, it kind of bounces off, right? Think of the force field we have in our intestinal tract and our vaginal canal and our urinary canal that kind of protects and so probiotics can help, obviously getting rid of the dysbiotic microbes can help, avoiding a lot of things that create the imbalances to begin with, which would be a lot of the antibiotics or maybe pesticides or GMO foods that produce a lot of antimicrobial compounds too. All those help avoiding those things too. 

Evan Brand: You know, what’s happening even in the functional medicine world, is that everything’s becoming isolated. Are you noticing that? Like people are focusing on just the gut. So, it’s like this leaky gut formula, this leaky gut protocol and they’re ignoring the fact that you just mentioned this IgA, this mucosal barrier is kind of a system-wide problem. So, there could be oral, vaginal, gut all at the same time, all related to the same dysfunction of these force fields being down. I think it’s just marketing, right? People just want to market that they’re the gut guy, they’re the parasite guy, they’re the Candida guy. I think that’s just a marketing probe but hopefully people are seeing this and of course if they’ve been listening to us for months or years, they’re seeing that this is a system-wide problem, it’s just manifesting in this way. 

Dr. Justin Marchegiani: Yeah. In the functional medicine world, a lot of people market to niche areas and symptoms which is fine because a lot of people when they get focused on something, they think they have these issues, they’re going into google or they’re typing that issue. So, for you to be relevant and for that person that has health issues to find you, you do kind of have to market to a symptom but then when you find that person and you talk to them, you wanna make sure that their approach is globally where they look at things holistically and you’re not seeing the gut person that only deals with the gut and they’re not looking at your thyroid or your anemia or your low glutathione. They’re not connecting the dots. So, you got to make sure they’re still able to connect the dots but multiple systems and they’re not just focused on one issue. So, it’s okay for doctors to market to that, you just have to make sure that their philosophy is a holistic philosophy that encompasses everything in there. 

Evan Brand: Yeah and holistic spelled w-h-o-l-e a wholistic, the whole thing, the whole body, the whole person, not just holistic as in natural, it’s gonna be the whole piece and I think that’s where I suffered for a long time because I focused on my gut for so long but I was ignoring toxicity issues, I was ignoring dental issues, I was ignoring tick bite infections. So now, oh crap, I see the whole picture and I would miss that if I just dialed in the gut so and that’s what you and I do. We’ve done this over with clients worldwide, we look at the whole picture. If you’re suffering, if you’ve been through the conventional rabbit hole or maybe you’ve been fortunate to avoid the conventional rabbit hole, you don’t want to go down it but you need help, feel free to reach out. Dr. J and I work with people around the world. We can send these labs that we’re talking about stool and urine. These are at home, these are non-invasive. It’s rare that we need to do invasive testing but most of the time it’s at home functional medicine tests can be sent to your door, you do them, you send them back to the lab. We get the results. We jump on a call. We run you through them. We interpret those. We make a protocol for you and get you better and get you off the merry-go-round. So, if you need help, feel free to reach out, Dr. J is at justinhealth.com and me, evanbrand.com and you can reach out, book a call with us, we’d love to talk with you, help you, find and fix the root causes if you just have UTIs and you think that’s all it is, maybe you’re right but maybe not, either way, we’re gonna help you get to the bottom of it. 

Dr. Justin Marchegiani: Very good. Excellent. So, for women that are listening and kind of want to recap here, first thing, make sure your diet is right, keep in the process refined sugar, grains, flours out, makes a huge difference. Omega-6, seed oils, in general, should be reduced as well. Hydration, make sure hydration is good, clean and filtered water, um, you know, good mineral water, especially if you have more health issues, more minerals in there is gonna be better. Next thing out of the gate, you know, urinate after intercourse, those kinds of foundational things. If you have chronic gut issues, definitely, get your gut looked at. If you’re on hormone, if you’re on birth control pills, definitely get your hormones looked at and figure out why you’re on them. Most women aren’t even on hormone or birth control pills for birth prevention. They’re on it for off-label issues like acne or headaches or lots of PMS and so most women could totally get off it because they’re not even using birth control pills for the original intention. They’re for off-label use and so that would require looking deeper at the hormones. Next, you can get tested, you can do either a, um, a MONISTAT test to look for yeast, you can get those at the drugstore, you can do one of the strip tests to look for leukocyte esterase or I think it’s nitrites in the urine for more of the UTI issues and of  course, if you have a lot more of the odor-like, uh, issues, you can get a vaginal swab from your OB or your primary to rule out any of the BV issues as well, again, similar solutions, you know, some maybe more internal in regards to what we recommend, some maybe more internal like with swallowing pills so maybe internally, intravaginally and of course the more chronic the issue is, the more we have to really support the vaginal microbiome with the right beneficial bacteria getting in there internally as well. And then, of course, just keeping up with a lot of the menstruation because that can really affect a lot of the, um, the bacterial issues and yeast issues in the vaginal canal because it’s gonna shift that pH from very acidic to more neutral to alkaline at that time of the month when you menstruate. So, hopefully, that’s a good kind of crash course, out of the gates and kind of you guys understand kind of our spitball kind of philosophy and how we look at the whole history and really connect the dots and we have our little toolbox of all these things but we just got to make sure it’s catered to the history.  

Evan Brand: And alcohol too, I think, we briefly mentioned it but alcohols got to go. It’s just, it’s not gonna help you. It’s going to promote all sorts of issues. It’s gonna aggravate the immune system. It’s gonna affect your IgA levels. It may promote dysbiosis and it may promote more yeast problems and so I’ve heard many stories where a woman’s like, oh yeah we went to Napa Valley and we drank wine and ate chocolate and salami and cheese all weekend and now I had a flare up. It’s like, well, yeah, duh, I mean, that’s incredibly damaging. Everything that you’ve done, you binged on wine all weekend so I think wine kind of gets like this people think that they’re not drinking alcohol. Somehow, they think they’re getting off the hook. Oh, it’s just wine, like, it’s so socially cool, it’s like coffee. It’s like coffee and wine, like wine is so accepted into the culture but it can be a big problem, I tell you. Some of those California women, the ones in San Francisco, like, it’s part of the culture here. I had one woman argue with me that she didn’t want to get off alcohol. I said, well, what if it’s gonna help your gut. She’s like, well maybe I’ll consider it. So, sometimes as practitioners, we’re having to bargain with people and try to make trades and make healthy swaps, we’ll swap it for this and try this and what if you do a binder afterwards. So, sometimes, you gotta work with people, they’re not just in a vacuum. We got to work with them and help educate them so that they’re more dedicated to the lifestyle changes but I just want to mention alcohol because I think a lot of people, don’t even consider the impact it has on the gut but then on this flora.    

Dr. Justin Marchegiani: Yeah. A couple things with alcohol, number one it’s diuretic so it will increase the frequent urination and kind of make you more dehydrated so good hydration helps prevent a lot of that bacteria from growing. Number two, out of the gates, you know, it may be necessary out of the gates for the first month so as you get things under wrap. There’re also healthier versions of alcohol. I mean, you can always get, like a Cosmo martini that has the fresh lime juice in there and cranberry juice. Just make sure it’s, like not the cranberry with sugar or the lime with sugar. Make sure, it’s fresh lime or actual juice cranberries with, like a nice Tito’s vodka, I mean, Tito’s vodka is, um, it is charcoal filter, right? So, it’s gonna be really clean and you can get some nice cranberry and lime in there that should be almost be beneficial in a way, obviously, you know, keep it, you know, a drink or two maybe once or twice a week max but once you better that maybe a good option to add things back in and just stay away from a lot of the sugary stuff and of course the glutinous drinks and you’ll be in a lot better position.   

Evan Brand: Yeah. It’s a funny thing you have to mention. There’s got to be real cranberries because most of the time you go to a bar, it’s like that. It’s garbage. The heart or it’s the high fructose corn syrup concentrate. 

Dr. Justin Marchegiani: Yeah. So, worst case, you can always just do a fresh lime squeezed in there and see if they have anything that’s just a pure, you know, extract and that’s a much way to do it. Of course, dry or white wines and you know just a good Tito’s vodka is always great with just the lime in and of itself. That’s an easy way to do it and keep the sugar and junk down but also keep a nice acidic pH there which is helpful for the vaginal area. 

Evan Brand: Yeah. We’ll hope, as you mentioned, no I think we covered It so if you need help, we mentioned the links here Dr. J, that’s Justin at justinhealth.com. You can reach out for consult worldwide. Me at evanbrand.com, either way, we’re here to help you guys. We love what we do. We have a blast and it’s fun to educate people. It’s fun to empower people and take back your health and it’s possible. Whatever you’re dealing with it’s possible to make progress so just keep your head up. Stay motivated. Don’t always run straight to that antibiotic if there’s another way. You may try another solution. If you’ve been doing this for a decade now and you’re still battling it, you’re not out of the woods yet, it’s time to look deeper.    

Dr. Justin Marchegiani: Excellent. Great chat, Evan. Everyone, have an awesome week. We’ll talk soon. Take care of you all. 

Evan Brand: Take care, now. 

Dr. Justin Marchegiani: Bye now. Peace. 

Evan Brand: Bye-bye 

How to Get Your Energy Back Post-Infection | Podcast #365

When people start to feel better after an infection, it is often tempting to return to previous levels of work, leisure, and social activities. However, too soon, trying to do too much can often be counter-productive. It is easy to get caught up in a ‘boom and bust cycle of activity that can prolong your recovery.

Dr. J and Evan discuss that if fatigue and other symptoms persist, it’s important to remember to allow yourself time to recuperate by finding the right balance of rest, relaxation, and activity for your circumstances. It is essential to listen to your body and gradually build a physical and emotional recovery plan that can help you get back to your life and stay on track without experiencing too many setbacks.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

0:00 – Introduction
5:11   – The essential vitamins to boost your immune system
10:12 – What is the goal of the Krebs Cycle?
14:06 – Mitochondria and microbiota dysfunction in viral pathogens;
17:12  – The role of mitochondria, oxidative stress, and the response to antioxidants in chronic fatigue
20:08 – The neurotransmitters from amino acids and tryptophan pathways in B6 deficiency

Dr. Justin Marchegiani: With Evan Brand, really excited today. We’re gonna have a nice conversation on how to get your energy back post-infection. This is the topic that we’ve been getting a lot from our patients and again a lot of our inspired podcasts and videos come from real life clinical work with patients. So, we’re excited to bring you the real-life actionable information here to improve your health. Evan, how you doing today man? What’s cooking?

Evan Brand: Hey. Doing pretty well, uh, cooked some bacon this morning and that was about it with some organic blueberries and so I’m feeling good. my brain is clear and I look forward to helping people on this energy conversation, you know, so many people have chronic fatigue post-infection and they’re not fully bouncing back and so, I think that there are some easy low hanging fruit strategies that we can talk about but I’m just gonna jump straight to the big smoking gun which is looking at your mitochondria. We’re seeing a lot of issues with mitochondrial dysfunction or mitochondrial damage. I’m also seeing issues with neurotransmitters. So, I think, if you are to pick one and only one functional medicine test to look at to investigate yourself after this infection and fatigue, it would be the organic acids because you can get a great window into not only your gut health. We know that with infections, it does damage the gut, we know that there are ACE2 receptors in the gut so people that are ending up with irritable bowel or diarrhea or other problems during and post infection, we can look at that. A stool might be smart too but if you had to start with only one thing maybe the window into your gut via urine organic acids would be good enough. But more importantly, I want to see what the heck is going on with mitochondria and what kind of damage do we have because once you have the data then you can put together a protocol to fix it. 

Dr. Justin Marchegiani: 100% agree. So, we know with chronic inflammation, especially like, post-viral inflammation. We know one of the biggest drivers is gonna be oxidative stress, right? So, oxidation is nothing more than your body losing electrons, right? And one of the big things that helps oxidation within any type of infection pre, ideally, we’re doing these things pre to mitigate al of the oxidative stress that’s happening at the mitochondrial level but simple low hanging fruit, out of the gates, is gonna be glutathione, vitamin C, these are really powerful antioxidants. Vitamin D even kind of fits in that category, right?  Your big antioxidants are ADEK, um, I’m sorry, no, those are your fat-soluble vitamins but E is gonna be an antioxidant A is gonna be an antioxidant, right? I would even say E and K would for sure but your B and C are gonna be your water-soluble kind of more antioxidants for sure but the big are gonna plug in, you know, post-viral oxidative stress and/or pre is glutathione and vitamin C, out of the gates. And we can also look at low-hanging fruit on the mitochondrial side, which plugs into the Krebs cycle and the electron transport chain is gonna be B1, which is thiamine. I would say B vitamins as a whole was great but B1 has a major, major role and I’d even say B5, as well, pantothenic acid. So, you have thiamine, B1, right? You have Riboflavin, B2. You have niacin, B3; Pantothenic acid, B5; Pyridoxine, B6; biotin, B7; folate, B9; B12 is your methylcobalamin or hydroxyl or adenosine. And so, we’re talking B1 and B5 are gonna be big when it comes to post-viral fatigue. Those are really, really important nutrients that we can add in out of the gates and, why it’s all of this oxidative stress that’s happening when this infection is present. And so, the more you can do things like hydrate, keep inflammatory foods down like the excess Omega-6 fatty acids, um, keep the carbohydrate and the sugar in check, right? That’s gonna play a major, major role in not adding fuel to the fire if you will as well.  

Evan Brand: Yeah, and you can do oral glutathione. So, we have a combination product, which is an acetylated glutathione along with an acetylcysteine. So, you can give your body the nutrients to make more. You can give the precursors but then you can also take just straight glutathione. There are some liposomal versions. There’s reduced glutathione. There’s a nebulizer version that you can take so you can inhale glutathione if you feel that there was some lung involvement. You may consider doing both. I personally did both. I did oral and I continued to do oral glutathione daily and then, also, during the acute situation, nebulized glutathione with silver. And then, you mentioned B vitamins and you can measure all this, right? So that’s the important thing is, you know, you’re shouting out all these different names but people can look at this, right? We can look at this on organic acids. We can look at the various B6, B12. You can’t look at every single nutrient in the body but you can look at a ton of nutrients from one urine sample. So, it’s pretty awesome. And then, vitamin C, believe it or not, we’re seeing a lot of issues with viral infection and acute scurvy, which is pretty interesting. If you just put it some of this data and scurvy into the research, I guess, it’s due to the oxidative stress. It’s happening quickly and every single person I’m seeing post-infection is showing low vitamin C. So, we’re just keeping people on 2 to 3 grams every day. We’re doing a powdered version with a mixed ascorbate. So, you probably don’t want to do just straight ascorbic acid and you probably wanna do like a sodium ascorbate, magnesium ascorbate, if you can get some citrus bioflavonoids in there too and just take it ongoing. Don’t wait until you’re sick. We, as a family, we just take vitamin C ongoing because we know it’s important for the health of your capillaries and all that. Can you speak on that for a minute? Like vitamin C and skin and collagen, I mean there’s a role in other things. People think vitamin C, immune, but there’s other benefits to see, right?

Dr. Justin Marchegiani: Yeah. Vitamin C plugs into making collagen, which is all of the connective tissue for your skin, uh, hair, you know, cartilage, vitamin C is really important for that. Vitamin C is a very similar molecular structure as glucose, right? Don’t quote me but it’s similar to I think C6H12O6 or O8, it’s right in that molecular area, looks very similar. So, what does that mean?  That means, vitamin C has a docking site on the macrophage that actually goes and gobbles up bacteria and potential viruses and it’s gonna use that vitamin C that docks onto that macrophage to deal with the oxidation. So, I kind of think of it as like a firefighter going into a house and the vitamin C is like that fire fighter bringing that hose to squelch that fire, to squelch it, right? That’s kind of what I see vitamin C as, right? And, it’s almost like with the macrophage, it has a docking site and that glucose can actually come in there because it looks very molecularly similar to vitamin C and it can almost dock on that receptor site on that macrophage and take that vitamin C where to be used. It’s almost like giving the fire fighter a water hose, taking the water hose out and giving him a gas hose and he doesn’t even know. It’s almost like that and that’s why glucose and high levels of glucose and when it comes to a lot of these post-viral illnesses, you’re gonna see people that have very high levels of blood sugar, insulin resistance and even the extreme on the diabetes side are gonna have most of the side effects of most of the issues partly because of the oxidative stress, partly because of poor levels, you know, when you have insulin resistance that’s gonna affect oxygenation, right? Because, you’re not gonna have good blood flow and when you have poor blood flow and poor oxygenation, we need oxygen to plug into that mitochondria as well. It’s part of, you know, the key nutrients, right? We talked about B vitamins, B1, B5, very important to plug into the Krebs cycle. Well, guess what, when you have a high level of blood glucose and you’re on that pre-diabetic to diabetic side, right, 110 to 126mg/dl on the blood glucose side, your body has to process that and if you just go pull up, you know mitochondria, Krebs cycle and nutrients, right, you’re gonna see all the nutrients that are involved in that Krebs cycle to process that glucose because how it works in the Krebs cycle, everything gets funneled down to acetyl CoA, right? So, you have glucose comes to acetyl CoA, fatty acids come to acetyl CoA, they can also go this way into ketones and then you have protein coming down to acetyl CoA. Acetyl CoA pumps around the Krebs cycle twice and if you look, there’s gonna be nutrients that have to come in there to help that acetyl CoA to come around and a lot of those nutrients are gonna be B vitamins, magnesium, amino acids and so, if you’re coming in with lots of glucose and you’re not bringing in a lot of nutrients to funnel down to the acetyl CoA side, you’re gonna run that Krebs cycle twice and you’re gonna be using more B vitamins than you’re coming in. So, you can actually create a lot of nutrient deficiencies and oxidative stress when you consume a lot more glucose because it’s a transaction fee for your body to process energetically. 

Evan Brand: Nice. Nice. That’s a great way to put it. And, the truth is people are coming into this infection with nutrient deficiencies already due to bacterial overgrowth problems, Candida problems, maybe post-antibiotic therapy, you know, they have issues with the gut now and they’re not making enough of their nutrients in their gut. And so, a lot of people will just depend on diet and they’ll simply, well, can I just get enough on diet, can I just eat liver and grass-fed steak and all that and get enough nutrients from that and I’ll say, look I’ve tested and I know, you have too. Over a thousand people and many of those people were already dialed in with their diet for years before they got to us. Paleo, carnivore, autoimmune, paleo, we’ve had people that have been doing an incredibly job with nutrient density and they still show up with nutrient deficiencies and so I would love if everyone could just eat their way out of this situation but I just think with the modern stress that we’re under we’re dumping a lot of those Bs. You’re mentioning all these that are fueling this cycle. We’re so depleted and burned out emotionally, physically, chemically, we’re exposed to toxins. We’re just not living in Paleo time, so Paleo, you can’t just like paleo your way out of this and you know, that’s why I used to call my podcast years ago ‘Not just Paleo’ and then I got rid of it, just call it Evan Brand now but, um, that was my whole thought at the beginning. It was like, man, if everybody could just eat their way out this and get enough Bs in the diet then you and I wouldn’t be needed. 

Dr. Justin Marchegiani: 100%. Let me just kind of break this down for people just so they can get a better understanding of what’s happening here. So, when we have oxidative stress, oxidative stresses, we’re losing electrons. What’s the whole goal of the Krebs Cycle? The whole goal of the Krebs cycle is essentially gathering up electrons. Okay, so, you have fats like I mentioned before, they’re all funneling down to Acetyl-CoA. Proteins all funneling down to acetyl-CoA, right? Then you can see on the carbohydrate side like I mentioned, look at a lot of the nutrients that are involved in funneling the carbohydrates down to acetyl-CoA, different B vitamins, okay?   

Evan Brand: Zoom in so, 

Dr. Justin Marchegiani:  B1, B2, B3, magnesium, all play really important roles and then look at the carbohydrates, look at the amino acids that are involved. Cysteine, that’s a major precursor of glutathione, serine, really important for stress. Glycine, that’s your major amino acid in collagen, right? This is why, when you’re stressed and you’re sick, it’s why your grandma tells you to have chicken soup, right, especially with the whole bone in there because you’re getting a lot of these amino acids in a liquid form. So, if your tummy doesn’t feel good and you’re nauseous, right, because the infections tend to really cause nausea because your energy is going to fight an infection versus digestion. So, it’s trying to shut that down. That’s why your grandma said chicken soup, right? Ideally, we keep the noodles out now. Now, look at the fats, right, look at where the fats can go so the fats go down to acetyl-CoA but it can also go and create these ketones, right. This is beta-hydroxybutyrate. This is a ketone, okay? Now, really important here. So, we have this acetyl-CoA, right, this is kind of our energy currency that everything gets converted from our three major macronutrients, fats, carbs and proteins. And again, if you’re listening at home, there’s a video version of this of me going through it. I know, it’s a little confusing but I’m going to try to make, break it down. Acetyl-CoA comes around this citric acid cycle or Krebs cycle. It’s the same thing. It goes around twice, okay? And you can see GSH that stands for glutathione. Fe stands for Iron. So, if you’re a female and you’re very low iron or you’re anemic or vegetarian vegan, that could be a problem. 

Evan Brand: So, let me pause there, really quick, because I want to point out something. You’re showing here on this cycle that you’ve got to have not only glutathione but you’ve got to have iron so you gave a shout out to the anemic women and what I want to point out is that the women that came into this infection, anemic, which is extremely common. Women have hormonal imbalances. It’s an epidemic problem so many women have heavy periods or maybe post childbirth, their period was screwed up and they’re having heavy menstruation. So, they’re coming into this anemic or they’re coming into this with low ferritin and then that’s compounded by maybe a mold exposure where now they have low glutathione levels. The way you’re showing this cycle here, if you come in with low iron and low glutathione, you’re in big trouble.   

Dr. Justin Marchegiani: You’re in big trouble. And, women are more predisposed because if they have hormonal imbalances, guess what happens to their period, they get heavier. Heavier period, they’re just gonna lose that iron. Now, men on the other side, men have it, you know, they can have increased iron. They can cause oxidative stress because iron is like, you know can be like gasoline on the fire if it does get too high, right? But you can see glutathione, iron, you can see B vitamins, you can see magnesium, you can even see manganese here and you can see different B vitamins. And, what they do is you’re creating NAD and FADH and they’re grabbing hydrogen, they’re grabbing electrons, okay? So, typically comes around here twice and you get usually two NADHs and one FADH2 per cycle and then essentially all of these things will jump into the electron transport chain next. If I could find that section here, but the electron transport chain is the next big step for that kind of gathers nutrients but for really, for today’s talk, this is the really most important thing and then just kind of highlight, you can see some of these toxins over here that come in, right? You can see fluoride, Hg is Mercury, As is gonna be, uh, arsenic, Al is gonna be aluminum. So, you can see some of these toxins, how they can kind of come in there and sabotage some of these things. And, to kind of highlight one thing, this is an article we saw here. Mitochondria and Microbiota dysfunction with post-viral issues, you can see how the gut microbiome also plays a certain role and why is that? Well, I think, because 80% of the immune is in the gut so if you have a pathogenic or dysbiotic microbiome, it’s gonna affect toxins being produced, right? It’s gonna put you right here in a hyperinflammatory state, right? We already have a lot more cytokines being produced if we have an illness and so we have to be able to calm down our immune system’s inflammation to what’s happening from an immune stress standpoint. And so, the microbiome plays a big role, iron dysregulation, reactive oxygen species, right? Vitamin C plays a major role here. Vitamin, uh, glutathione plays a major role there as well.

Evan Brand: Yeah, right there, look at that one, the mitochondrial, the heightened inflammatory oxidative state may lead to mitochondrial dysfunction and so this is what we’re seeing on paper. We’re seeing this in the stool test. We’re seeing this in the organic acid test, this issue with the gut with the mitochondria. 

Dr. Justin Marchegiani: Yeah. It talks about platelet damage too which is important because what do platelets do, those are your clotting factors. And so, if we can have increased coagulation cascades, that means more clotting, right? And, you can see more clotting events, more thrombosis is that’s a blood clot, right? And so, you can see furthermore, mitochondrial oxidative just make, may contribute to microbiota dysbiosis altering coagulation and fueling inflammatory oxidative response leading to vicious cycles of events. So, this is really important and so things that we can do to be on top of the fatigue is gonna be the same things that we can do to help mitigate a lot of the inflammation. That’s gonna be keeping blood sugar in check, adding in some of these additional B vitamins, um, adding in anti-inflammatory anticoagulants. What do those look like? That could be ginger. That could be curcumin, which has anti-inflammatory and anticoagulation effects. That could be adding some extra Cod liver oil that has more vitamin A in it, which is a really powerful antioxidant but it also has natural blood thinning aspects because of the extra omega-3s in there. So, there’s different things we can do to really help reduce a lot of that inflammation. Any comments on that, Evan?  

Evan Brand: Yeah. On the more intense side of supporting hypercoagulability, lumbrokinase is gonna be your most powerful. That’s your earthworm-based enzyme, which is just a cool, cool thing. Natto, there’s also serratiopeptidase, so there are other enzymes that you can use and I personally take those. I take lumbrokinase, one per day just ongoing and it’s been very helpful. I also did a podcast with Dr. Thomas Levy, all about vitamin C IV and he’s got some dark field microscopy photos of people that we’re having blood clotting issues and the vitamin C along with ozone and IV was like a game changer and vitamin C can help energy too, so I don’t want to get too deep in the rabbit hole of blood clots but we’ll just say that the vitamin C is helpful for energy also. 

Dr. Justin Marchegiani: 100%. I want to show you guys one other journal article here, role of mitochondrial oxidative stress and antioxidants when it comes to chronic fatigue and so one kind of thing here, it talks about the known role of oxidative stress and how it can relate to essentially fatigue, as well as, potential, uh, specific therapeutic treatments for the mitochondria so that’s really powerful. And, you know, here are some of the big things, they’re gonna talk about vitamin C, talk about B vitamins, talk about glutathione and then also some of the more natural anti-inflammatory things but you know, each study is going to find out focus on a couple of their major things but, people in the literature are looking at these things. It is real and, um, we’re seeing it in our patients and we’re trying to apply some of these things to get people’s health back.  

Evan Brand: Yeah. So, the way you look at this is what you can do to protect against oxidative stress, we covered that glutathione. What can we do to help support the Krebs cycle? We talked about B vitamins. You’ve also got just things that are gonna help the mitochondria in general, like CoQ10 and then also you can do things like PQQ and there’s other nutrients that actually create what’s called mitochondrial biogenesis where you can literally make new mitochondria. And so, I don’t think it’s in that paper, it does mention CoQ10 there but 

Dr. Justin Marchegiani: Right here in the mitochondria, there are enzymes and coenzymes such as vitamin E, CoQ10 to remove ROS, that’s reactive oxygen species to prevent DNA damage. So, these are really powerful things that we can add in. For example, low CoQ10, they’ll see an increase in damage, so Coq10, PQQ, you know pyro quinolone, right? Vitamin E, and then, you know, we try to give Coq10 with vitamin E together for that same reason to prevent a lot of the oxidative stress while fueling the mitochondria. Any comments on that? 

Evan Brand: Yeah. Look at the next part there too, talking about exercise. People that come in with chronic fatigue and how they’re having an increased oxidative stress after exercise and that’s a problem that we’re seeing a lot too is people that now are having, uh, post-exertional fatigue, people that are crashing. Even athletes that were really high performing people that now their performance is just in the tank and a lot of that is just this ongoing oxidative stress and mitochondrial damage that’s not, that’s not been supported and you can’t just exercise your way out of this and I get kind of annoyed when I see like those motivational videos of people that are really sweaty like you just nee to suck it up, you know, pain is weakness leaving the body. It’s like, no, you’re wrong, you got to fix the mitochondrial damage. I hate those like raw-raw videos because it’s ignoring all the nutrients. That video really needs to be talking about, hey get your glutathione up, get your ribose up, get your CoQ10 up, come on people, like that’s what he used to say.  

Dr. Justin Marchegiani: And this is a similar marker that we use on the organic acid test, the one that we use 8-hydroxy-2-deoxyguanosine, this is very, very similar to that. But this is a marker for oxidative stress so we’ll actually use the same marker on a, um, on a mitochondrial test on the organic acid. So, we’ll look at some of these things to get a window of how stress these pathways are so that’s very powerful. 

Evan Brand: Yeah. Ribose is amazing. Carnitine is amazing. Acetyl-L-carnitine is amazing. Also, you know, let’s hit the, let’s go up a little bit like that picture there was a like a neurotransmitter picture there that you had. Maybe, we should talk about that a little bit because it’s not directly gonna be a mitochondrial support, yeah, right there, but I think, that’s cool to point out too, which is that, if we’re coming in with nutrients like phenylalanine or tyrosine, eventually some of that may convert over to your neurotransmitters but then also your adrenal hormones like epinephrine and I think a lot of people and I know you see this too, a lot of people are showing up with just low brain chemistry across the board. And so, I’m thinking out loud with you that like, the real magic remedy is the mitochondrial support plus throwing in some of these neurotransmitter supports as well. 

Dr. Justin Marchegiani: Well, that’s why we talked about B vitamins and I kind of went to the gamut, look how important B6 is in regarding the synthesis of tryptophan to serotonin, really important so you can see how B6 deficiency is really important in this process to convert this inflammatory product here, quinolinic acid, uh, back to tryptophan, it needs B6 or to avoid that whole thing it needs B6 so that’s really important. So, B6 is really important in the synthesis of amino acid tryptophan to serotonin, very important.   

Evan Brand: And so, vegetarians, vegans, obviously, you’re gonna be at increased risk of issues and your recovery is not gonna be as good as someone who’s getting these good animal proteins because you’re gonna be getting adequate tryptophan and other nutrients from your animal-based products. So, even if we could get these people on eggs, if we could get these people on organ capsules, if we could get these people on even like a protein like, I’ve got one we call carnivore collagen, which is a like a beef peptide, I mean something you gotta supplement at some level if you’re not eating those foods. So, please, if you’re a vegetarian vegan and you’re exhausted then look at some of this and hopefully we can convince you to change and improve your diet a bit. 

Dr. Justin Marchegiani: Yeah. No, I totally agree. I think that’s really important. I want to see if there’s anything else here, I want to highlight now because that’s enough, that’s powerful enough. Anything else, you wanted to highlight there?

Evan Brand: Well, we hit the urine, we hit the stool. Looking at the gut, you showed the study about the gut changing, we’ve seen that, I mean, you and I were talking about that march of 2020, I mean that was 2 years ago. We were talking about being affected. And so, obviously, our message is the same that it’s always been is get your stool looked at so we can see what kind of dysbiosis do you have going on because if you’re taking all these supplements, you’re doing all these foods but you’ve got malabsorption or you’ve got gut inflammation. You’re not gonna, you know, people say you are what you eat but you really what you digest from what you eat. So, if you have all these other issues in your gut, the grass-fed steak is not gonna be as valuable to you. Now, I’m not saying stop eating it, I’m saying still eat it but we’ve got to improve the digestion and assimilation of that. 

Dr. Justin Marchegiani: 110%. And one thing here, I just want to highlight here, just to kind of this article, it’s talking about mitochondrial function in infections in the gut because we’re trying to talk about mitochondrial and energy post-illness, that could be a viral illness, it could also be a gut illness, right? Because, it’s talking right here, even virus dedicated virulence factors and talks about downstream of an infection. It’s fascinating that a plethora of immune responses but, uh, be it against viruses, bacteria or LPS. LPS is lipopolysaccharides or endotoxin, this can come from H. pylori, this can come from SIBO, or dysbiotic bacteria and they strongly impact tht mitochondria which is really, really important because they’re toxic, they kind of throw a monkey wrench in how the FADH and the NAD is kind of moving around the Krebs cycle, collecting hydrogens and then bringing into electron transport chain. It talks about, um, governed by the mitochondria can be translated into active therapeutics to boost immunity against pathogens to over immune responses under control in the case of inflammatory disorders. So, essentially, the more you have these infections there, the more inflammation your immune system creates that can actually impact your mitochondria. Again, when you have a lot of these illnesses, it’s not just the stress from the illness, it’s the immune response from your own immune system that creates inflammation that can actually disrupt your energy pathway. So, sometimes, you’re just fighting against yourself. And so, using nutrients to help modulate the immune response i.e., glutathione, Vitamin D, vitamin C, right, really important nutrients there. I’d also say, you can do things like curcumin, or resveratrol as well. You can have immune modulating effects. These are powerful. So, it’s good to kind of get your immune system in check. Most people that are having longer term, we call it kind of long haulers type issue. It’s typically their immune system has over responded and it’s just creating so much inflammation. So here, this illness, they’re no longer testing positive for whatever this illness is and they’re prolonged 2 to 3 months out and they’re feeling like crap still, it’s because they really didn’t get their immune system’s inflammatory cascade in check afterwards.    

Evan Brand: Yeah. Well said. So, a couple comments. Number one, you can improve your energy by simply fixing your gut and that’s exactly what that data is showing and that’s exactly what you and I have seen and done clinically, hundreds and hundreds of times. People that were exhausted coming in, we give them a gut protocol, sometimes, not even giving them energy supplements because on paper they look good and all of a sudden, their energy level doubles and all we did is fix their gut so that’s the number one comment. And then number two comment is that, people need to stop waiting for some illness like this to take them down before they take this stuff serious. I mean, you and I are all about preventative approaches meaning getting your mitochondria, you gut, your brain chemistry getting all that stuff optimized now so that you’re a warrior on a daily basis so that when you do come across something like this and there probably will be more things like this that you do to get exposed to, you’re ready and you’re able to handle it and you’re not coming in so sick and looking for this emergency therapy at the end stage, it’s, in some cases, it’s too late. I think, a lot of times you can turn it around but you should have been working on your health years ago before you got this stage.  

Dr. Justin Marchegiani: Yeah. And a lot of it is, you know, anytime you have some type of illness coming up, the more you can be on top of a lot of these key immune modulating anti-inflammatory nutrients ahead of time and or during versus coming in at the end when the inflammation is super high. It’s like coming in when the fire is a little baby fire and knocking it out versus having a full five alarm and trying to stop it, right? That’s kind of the analogy. So, I always recommend telling people have a couple of nutrients. You may not be taking it everyday but they may in your medicine cabinet is kind of like a, um, you know, last ditch kind of effort to kind of come in there if you start to feel a little bit ill so on my line, we have Immune Supreme, which is nice because you have some green tea in there, you have some echinacea, you have some medicinal mushrooms, you have some antioxidants and some immune modulators, that’s kind of cool. Have that in your medicine cabinet. You start to feel the tiniest thing, start taking that to get that immune system, obviously, you can ratchet up, vitamin D, vitamin C. These are easy first line things, if you have any NAC or glutathione, we can ratchet that up. These are easy things that we can do to kind of take charge of our health and prevent our immune system from throwing us off.  

Evan Brand: Yeah. Well said. And, if you need help clinically, we do offer one-on-one consults around the world with people so we’re very blessed to be able to help so many people by getting the proper testing done, making the proper protocol to get you better. So, if you don’t test, you guess, you got to see what you’re up against first, look at your Bs, look at your gut, you know, once we get the data, we can help you more accurately and you’re gonna save a lot more money, a lot more time and a lot more suffering and you’re gonna get out of the dumps out of the trenches, out of the depths of hell, depression, whatever you’re dealing with. You’re gonna get out of that faster if you’re using clinical data and you have a tour guide to your body. So, if you need help clinically, you can reach out to Dr. J at justinhealth.com for consults worldwide or me, Evan Brand at evanbrand.com and we’re here for you guys. So, we look forward to helping you out.  

Dr. Justin Marchegiani: 100%. I appreciate it. Yeah. Anyone that wants to reach out, Evan already gave you the links, really appreciate it. Comments down below, I really appreciate your feedback on that and also, we’ll put links down below with some products that we chatted about. We have different ones that we recommend in our line. Just wherever you go, make sure you get them from a professional grade company because raw material does matter in the supplement world. You can buy, you know, the equivalent of the grass-fed steak from the local farmer or you can get it from McDonald’s, right? And so, we want to get the high-quality raw material that’s tested to make sure there’s no impurities and just building blocks are excellent. Evan, excellent chatting with you man, really appreciate it. Guys, um, have an awesome week and we’ll talk soon. Take care you all. 

Evan Brand: Take care, now. Bye-Bye. 

Dr. Justin Marchegiani: Bye. 

 

How to Reduce Inflammation and Improve Joint Mobility | Podcast #359

When you think of joint mobility issues, you’re probably thinking of inflammation. Inflammation is a process in which your body’s white blood cells and immune proteins help protect you from infection and things like bacteria and viruses.

In this video, Dr. J and Evan Brand discuss that your immune system triggers an inflammatory response when there isn’t anything to fight off in some diseases. With these diseases, called autoimmune diseases, your body’s immune system damages its tissues. Your body responds as if normal tissues need to be fought off. These are all linked to diet modification and testing that needs to be done to make you health better.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

0:00 –  The benefits of movements to joint mobility
5:23 –  The benefits of ergonomic chairs and tables for your back
18:56 – The vital role of proper diet for better joint mobility of reduction of inflammation
30:04 – The anti-inflammatory benefits of ginger for joint health


Dr. Justin Marchegiani: With Evan Brand, we’re gonna be going into reducing inflammation in the joints and how to improve joint mobility. We’re gonna be talking about it more from a biochemical kind of metabolic inflammation standpoint. So excited to dive in on that topic. Evan, how are we doing today man? What’s cooking? 

Evan Brand: I’m doing pretty good. I was telling you about my shoulder. I was lifting some heavy things over the weekend and my shoulder got a little tight on me. I thought, oh oh. So, uh, that spurred the idea of this conversation and I hit some arnica homeopathic 30c which worked very well. It’s not necessarily the root cause but it has been helpful and you know I wasn’t trained on homeopathy so this is something you and I have kind of dove into in our personal lives with our kids and such and it’s been a game changer. So, I mean, out of the gate, I think that’s something to have on hand even if you don’t know biochemically your root cause, what’s going on, at least you could remedy your situation, feel a little bit better well and buy some time while you’re investigating. 

Dr. Justin Marchegiani: 100% So, when I look at joint issues right, you have physical inflammation that’s being caused by physical things, right? The most common things are going to be either over exercising too much, probably less common on that and the other one is just very poor posture, right? So, the easiest thing out of the gates is you’re either sitting in a really poor chair that has very poor lumbar support, right, lower back curve support or cervical curve support. So, the easiest thing is just getting a really high good quality rated ergonomic chair especially if you’re sitting a lot, right, that has cervical support and lumbar support, that’s super helpful. In that way that part of the spine is supported. Ideally, being able to stand a portion of your day. I mean, right now, I’m standing. I don’t think you are. So, I stand at least half of my day. I have a treadmill that I’ll slide it under there. I have a Cubbi stepper. So, I’m always trying to keep some movement in there. I get about 15,000 steps a day so it’s very helpful to be able to move, get some steps. That’s helpful for the joints. The disc in the joint get hydration through inhibition. So, the joint has to pump and move to get hydration into the joints. So, movement through the joint is super helpful. So, being able to stand for a portion of the day, sit a little bit with good support, getting some movement, super helpful. And then depending on the kind of where you’re at, if you have inflammation, if you have pain, I mean, you can do some simple core kind of postural functional movements to strengthen that area. I mean, one of the things I like, uh, is a book by Eric Goodman called Foundation Training, where he just does some simple posterior chain work like a standing prone cobra with the chin pull back, right, that activates the deep cervical flexors here. I mean, you can bend down to a 45-degree angle like this for 30 seconds. You can also bring it up like this and get the whole posterior chain activated and then you can also reach down and then create traction with the spine so go look at Eric Goodman’s work. He is a, just that these three or four movements called the founder that, those are really good movements to get the posterior chain like this, like this. Simple stuff out of the gates. And so, I like that to get the posterior chain, good stability with your chain, investing good money on your desk chair. Get sine ability like a stand desk to be able to stand up throughout the day even if you’re just kind of moving going back and forth. These are super easy ways to kind of get simple movement through your spine during this, you’re not sitting all day. And if you’re sitting all day, at least invest in a really good chair and try to get some of the stand desk where you can go up and down.

Evan Brand: I do this little bar stool too and that way I could just lean my butt on it. So, I’ll just put my butt on that but I’m still standing. I’m just kind of leaning back on it. I know there was some really expensive thing, I can’t remember the name of it, a few years, I think Marxism was promoting it but it had like rocks. It has this thing that he learned. It was almost like a pogo stick with a seat and so it was like this imbalanced chair. You’re sitting but you’re standing but there’s some like rocks on the floor and so he’d put his bare foot on the rocks. I don’t remember what it was but this is kind of my homemade version of it, this little bar stool that It’ll just kind of leave off kilter. In that way my butt’s just taking a little bit of load off because if I just try to stand all day, my back hurts. So, standing all day just doesn’t work for me but with a little bit of lean, it helps.  

Dr. Justin Marchegiani: Yeah. They have these, um, these little, they’re called like wobble board chairs. There’s one called the Luna standing desk tool. It’s kind of like that, it’s kind like a pogo stick, right, but it’s got a flat surface, that’s kind of oblong so then you’re kind of sitting on that. You kind of have balance so then it activates the core but then you can kind of move around, kind of get some movement in your hips which is good for your spine. You can also just get like a Swiss ball, right? Just sit on one of those in that way, you can get some movement. And you won’t have so much support in the back so you really have to activate your core, activate your back so you can sit up there straight. That’s good, nothing wrong with that so that’s helpful. You probably wouldn’t want to do it all day because you’d be really keeping these muscles active all day but it’s nice if you’re at a desk, you can at least bring that in and bring the wobble board stool type of chair in there. These are a couple options, you know, minimal cost to bring in some good core activation. And when I say core, core is everything. It’s like the whole core thing is your back, it’s multifidus, it’s your iliocostalis muscles, right? It’s your longissimus muscles, it’s obviously your TVA, it’s your rectus abdominis, it’s your oblique, transverse, external, internal oblique, right? It’s everything around your back and front abdominal area. 

Evan Brand: People may be listening and go ‘God, why does that be so complex, I gotta get to this fancy chair or this or that’. Because, we didn’t really evolve if we were sitting like this all day staring at a screen. I mean, we’re just not really built for this, so it’s no surprise that we see so many people with mobility problems. I mean, I’ve been to several different physical therapy people over the years, just for random injuries and aches and pains and they all tell me that in their careers, these are people that have worked 20, 30, 40 years. They’ve seen just the rise of younger and younger people having worse mobility because they’re just sitting at a desk all day and how it’s shortening the muscles. I think it’s the hamstrings, right? It’s shortening the hamstrings when you sit all day?   

Dr. Justin Marchegiani: Well, I would say it’s probably shortening the hip flexor muscles, right? Because the hip flexors, right, when you flex the hip, you’re shortening that muscle so you’re creating that muscle shortens and that muscle, its insertion is on the lesser trochanter in the hip flexor in the femur muscle, in the femur, uh, bone so the lesser greater trochanter muscle, the top part of the femur but then it inserts, no, that’s where it inserts. Its origin is I think from L1 to L5 on the spine. And so, when you have tighter hip flexors, it pulls super tight on the origin which is going to be L1 to L5, I think, transverse process, and even the ribs.  So, it’ll pull really really hard on that back and so a lot of times, your chronic lower back pain is gonna be from the shearing force from really tight hip flexors, that’s part of how lower crossed syndrome happens, right? Lower crossed syndrome is nothing more than super tight hip flexors on one side and on the other side weaker glutes and weaker lower abdominal muscles. Weaker abdominal muscles, weaker glutes because you’re not using glutes to step up or squat or lodge and then you’re getting these shorter, tighter hip flexor muscles and that’s the lower crossed syndrome, right? One cross is weak and loose or weak and tight, that’s your hip flexors, the other one is, um, weaker, that’s the glutes and that is the lower abdominals. And so, this is common and so people talk about investing a lot of money in beds, right? I have a nice Tempur-Pedic bed, that’s pretty expensive. I know you have a nice bed as well but we spend just as much time in bed as we do sitting in our chairs all day, so I think, you should, people should have, you know, enough money invested in a really good chair that has good postural support. You can go to like different ergonomic stores. There’s one in Austin called Human Solution on Anderson Lane. They have a lot of great options. I got my stand desk from them. They have some really good ergonomically certified chairs that are excellent, that have the cervical support as well as the lumbar support. These are really good options to kind of start out of the gates. So, kind of my thing is start with like, you know, the easiest buy-in, right? The easiest buy-in out of the gates is upgrade your chair, maybe get some swiss ball that you can sit on, maybe get your desk, get your stand desk so you can go up and down throughout. These are just some simple, easy investments. And if you already have these things and you wanna get more kind of biohackerish-like we are, I have a Cubbi, little pedals here so I can pedal. I have my little, um, I actually got a new treadmill desk that’s under my desk that’s lighter and it goes four and a half miles per hour and I have a remote, I can just hit it. 

Evan Brand: Spell Cubbi. 

Dr. Justin Marchegiani: C-u-b-b-i. And then my other treadmill, hold on, let me go look at real fast. And my new treadmill desk is Rhythm Fun. I’ll put the links down for Amazon below. Take a peek at. But the cool thing is the remote because you can just kill it, turn it off, turn it on. Without having to go touch it. 

Evan Brand: Now, if you don’t sit at a desk all day, congratulations. Hopefully, you’re out working in the field or something like that, you know, years ago, I was working in the woods and building hiking trails and restoring different natural, you know, natural areas, nature parks and stuff but man, it killed my back. I mean, it was a lot of work, a lot of labor and not much pay at all, could raise a family on that wage. So, if you are out and you’re physically great, that’s awesome or if maybe you’re just doing that in your free time, maybe that’s counteracting your desk work. I mean, that’s what I try to do, it’s even in the middle of the day for lunch, I’ll just try to go out and walk around even if I just like hiking up and down my driveway. Just something simple, just to break it up. And I forgot what her name was, it was, uh, Joan Vernikos. I had her on my podcast probably almost like 10 years ago. I think she worked with NASA or for NASA, but anyway, she talked about the importance of just standing up and sitting down and just the change in posture was more important than anything. She said, it wasn’t necessarily the actual exercise, it was just breaking up you’re sitting. So, if you’re sitting for 20 minutes and then you can stand for 10 seconds, that was enough she said to, you know, positively impact your mobility.  

Dr. Justin Marchegiani: Yeah. I mean, adding another 90 degrees of extension onto my hip flexors, right? If your hip flexors right at your leg to your hip you’re at 90 if you’re sitting. Well, if you’re standing you go to about 180, 160 – 180 right? So, I create more length to my hip flexor which means it’s less likely to get tighter and shorter and create lower back pain. And so, that’s the easiest thing, so there’s a lot of different buy-ins, right, so like we’re not trying to give a one-size-fits-all, we’re trying to say okay if you already have a good desk or already have a really good ergonomically supported chair, maybe upgrade into a stand desk or just get a simple physio ball. Ideally going from sitting to standing is ideal. So, I would say good chair, then go to a good desk and then if you wanna add a physio ball or a wobble chair, that’s great. And then, if you wanna go to the next level and get a treadmill that slides underneath, I think mine was 500 bucks which is great though. My other one was a Rebel Desk treadmill that I used for five years, I just got rid of it because of the belt, just like almost I wore though and I’m like doing the math. I’m like all right it’s about the same cost to repair it as to get a new one. That goes a little bit faster and I get the remote. So, that’s kind of where I’m at. So, there’s a lot of different buy-ins. Now, that’s kind of like the lifestyle exercise movement standpoint and remember, I’m not saying crazy exercise. I think the more you can get movement throughout the day that’s non structured is better. Meaning, if you can get 10, 15 thousand steps throughout the day where it’s non-structured throughout a 10-hour, 12-hour a day that’s good because if you just exercise for 30 minutes and you sit on your butt for 10 hours, is that really that good? You’re still sitting down not moving for 10 hours, that’s still not great. So, if you can get a little bit of movement in and you can also have a lot of unstructured movement, that’s even better, I think overall. 

Evan Brand: I would say so, I mean, I certainly can tell you the days that I exercise and then sit for too long, I’m just as stiff as if I did an exercise compared to times where I’m moving around throughout the day. So, yeah, I think throughout the day is better. Let’s get into some of the chemical stuff too, some of the infection stuff, I mean, I’ll tell you personally with some of the stuff I’ve had from tick bites. whether it’s Lyme, Bartonella, Babesia different things that create inflammation and affect blood flow, I would tell you that there are some waxing and waning periods like where hands, feet, knees, hips, that kind of thing can get tight and so I think, ultimately, you gotta test not test. So, you and I have talked about this before. Not all testing is a hundred percent accurate but we do feel that the DNA connections report does give us a pretty good read for different types of Borrelia that we can look into Lyme then some of the co-infections which the name co-infection kind of sounds like it always comes with Lyme, I do believe some people just have Bartonella or Babesia. And those things can really affect people in terms of mobility so for me, things like Japanese knotweed are very helpful and I take a tincture of Japanese Knotweed and of course we’ll mix that into some of the other stuff we’re gonna dive into but you have to investigate this. So, if you’ve got mobility stuff or if you sit for a while and you get stiff or if you’re having issues just making a full fist, you can’t fully get those fingers in, make a full fist, there’s probably something there, infection-wise.    

Dr. Justin Marchegiani: Well, anytime you create chemical, so I kind of look at like, all right, we have structural inflammation and we kind of just talked about postural things like things that you’re gonna be doing sitting, standing kind of lifestyle habits, so not like going to the gym like, right? That’s kid of like our physical but you know more lifestyle. Now, we have our chemical and the more inflammation we put in our body, the more it decreases blood flow to tissues, the more it exacerbates prostaglandin 2 and arachidonic acid which are more pro-inflammatory. It’s gonna decrease inflammation, decrease blood flow and then we, when we, sorry, increase inflammation and decrease blood flow, decrease oxygen, so when we do that, the tissue starts to become less pliable, right? So, think of like beef jerky, very like not pliable, like you have to rip and tear it. The more inflamed you become, the lack of blood flow that you have, right, the lack of nutrition to the muscles, the more your muscles become less pliable, less like a nice raw beef tenderloin and more like beef jerky. That’s not good. So, when you do movements, you’re more likely to tear and injure tissue. And obviously, if you tear muscle, that’s more vascular tissue, it has good blood flow so it can heal better. But as soon as you start affecting cartilage and tendons and ligaments, that tissue is very avascular, very poor blood flow so it’s gonna be very difficult for that to heal. So, big things that we can do is, you know, more vegetables less fruit and carbs so keep your carbs in check. Again, if you’re more active, you can do more carbs, be very careful of your Omega-6 vegetable oils, ideally, you know, two to one on your high-quality saturated fats, really important and then you can do on your vegetable side, you’re better off doing your mannose, right? Avocado, olive oil, be very careful of your nut and seed-based oil and your omega-6 like sunflower, corn, soy, canola, very inflammatory and of course things like gluten, processed dairy, processed grains, sugar, these things are gonna drive more inflammation, they’re gonna decrease blood flow and just when the more inflamed you are, it just, it can create a lot of inflammatory molecules going through the body and they just make your body more stiff, more inflamed. The more stiff you are, you can’t get full range of motion, your tissues start becoming less pliable and easy to tear and injure and you feel just more stiff throughout your movements. 

Evan Brand: Yeah, well said. And then on the conversation of Lyme, for example, I mean, we know that Borrelia, in general, likes to eat up your collagen, I mean, it’ll really try to hid out in joints and such, so I think, collagen supplementation may be helpful too, just trying to replenish some of what’s eating up. But then, you just got to clear some of the infections, I mean, I’ll tell you, if I’m doing some of the anti-Borrelia formulations whether personally or clinically, people can move better. So, if you’ve had tick bites if you grew up anywhere, almost anywhere in the U.S. except for maybe Nevada or New Mexico, supposedly there’s not many ticks there. But beyond that, if you have tick bites from childhood, I mean that could be a factor to look into. This could be a dormant infection that’s left you alone for 30 years and then all of a sudden, you got exposed to mold or you had a death or a divorce or a move or a major job stress or even just the pandemic that’s been going on. And some of that stress people out of the sudden, boom, they have these major joint problems so who knows, there could be a trigger but like you said, it could just be, over time lack of blood, inflammation together. So, what about, like..

Dr. Justin Marchegiani: All these things modulate the immune system, right? And so, like, what you’re gonna see is you’re gonna see an increase in arachidonic acid, which a lot of these things are come from meat, so it’s not bad to have too much arachidonic acid but if we increase prostaglandin 2, that’s a more proinflammatory pathway. So, vegetable seed oils, omega-6, too much arachidonic acid but if you balance it with omega-3, high quality grass-fed meat which is very high in GLA. It’s not necessarily the fact that you’re getting it, it’s more of the ratio of where you at with the others and so that’s why, really what’s gonna tip you over is the processed sugar, the hydrogenated oils, the trans fats, the soy, the canola, the sunflower, too much nuts, too much seeds, that’s gonna tip you over and put you into a more proinflammatory state. And then the more sugar you eat, the more grains you eat, the more your tissue starts to become less pliable. Now, I have a history, like, doing applied kinesiology work and using percussion work, and um, chiropractic work. I remember working on a patient and they literally, their tissues literally felt like a bag of cement and this person, like, couldn’t like, so we would use a percussor, we’d do some soft tissue but we, I noticed that when we got gluten out of that person’s diet and grains out of that person’s diet and sugar out, the tissue quality totally changed and it’s like if you’re inflamed and you have such poor movement, you’re not gonna want to move but then if you don’t move the tissue gets tighter and if it gets tighter then now you restrict your range of motion and you’re, it’s a vicious cycle, right? So, you kind of have to get some movement in there, you have to loosen up the tissue, you have to make the diet changes so you get better blood flow but you got to work into it because if someone’s coming in, really inflamed and they go too over the top, they may create so much inflammation that they have a paradoxical reaction to feel worse, so you really wanna ease into it. And so, if you’re not used to walking, just walk a little but try to exercise just enough where you repeat it. That next day, you may feel a little bit sore but you can still function, you can still do all the things you do. If you feel too sore the next day, where you can’t do what you have to do, you probably did too much. So, just enough to feel it and know you did something but not enough where it affects your you being able to function.   

Evan Brand: Yeah. I got a few physical therapists clients and they tell me straight up that they know they’re never fully gonna get their patients better because of their diets and these people are coming in, you know, they’re eating like a subway sandwiches as they walk into the physical therapy office, so the physical therapist doing the best they can but they know just listening to us that they’re never fully gonna get them better without the diet changes and then they’re like well that’s out of my scope of practice. I can’t, you know, educate them much on diet so I’ll try to hint at it but yeah. It’s sad because you see billions and billions of dollars being spent per year on physical therapy, occupational therapy, physical rehab, that kind of stuff, people maybe had car injuries, for example, where there was a traumatic event that led to this mobility problem but then they never fully recover because they go right back eating the RB sandwich, you know, the roast beef and the bread and the ketchup and they never fully get better. So, I think, there’s a place, hopefully, people pick up on this, you pass this information onto maybe a physical therapist, get people off of grains, get people off of dairy, at least temporarily of dairy. I think butter, there’s maybe a place for that in most people’s diets. But I will tell you personally, I’ve seen the changes in my own family members if we can get them off gluten or off grains even for a month, we see improvement and so it’s just this doesn’t make money for people, I mean, there’s so many pharmaceuticals that people are taking instead, right? What’s the conventional approach for these issues like Aspirin, Tylenol, maybe Aleve and maybe some anti-inflammatory steroid drugs, right, I would say in severe cases, those are being useful. 

Dr. Justin Marchegiani: Yeah. I mean, you have your, like NSAIDs, which are gonna be like your Ibuprofen, your Advil, your Aleve, right, I think your Aleve’s kind of your time-release Ibuprofen, right. These are gonna help with the prostaglandin 2. And then acutely, you know, for a couple of days, if something happened that may not be a bad idea. The problem is if you’re chronically needing these medications that’s the problem. And then you have your acetylsalicylic acid, that’s your aspirin and then you have your acetaminophen, which is Tylenol, again Tylenol blocks the pain receptors so it’s not an anti-inflammatory. Aspirin is a mild anti-inflammatory. Ibuprofen is an anti-inflammatory. And then you keep on going up into the steroids where you actually get an injection, the problem with that is after one or two injections, your anesthesiologist or your pain doctor will tell you, yeah, we’re gonna start to break down tissues and cartilage and tendons, that’s not good either. And so, I tell patients, you know, one, you don’t wanna jump on injections right away because you want there to be some pain signal to tell you you’re doing too much when you’re rehabbing. So, it’s good to have some pain signals that will tell you, ‘hey I’m doing too much because the problem with this medication is it covers up the pain and then you may be doing things in your life movement wise, it’s actually creating more pain but you can’t feel it right. So, then of course, you go up the ladder and you’ll eventually be on opiates and that’s the problem and that opiates are very addicting, it’s just basically telling it’s blocking the brain’s ability to perceive pain and then essentially the longer your on an opiate, um, you know Suboxone, of course, you have the incredible, your morphine post-surgery, you have Fentanyl which is like incredibly higher version above your oxytocin which is like time-released opiate, it rewires the brain and you start to need more of it to then block that pain signal and then that creates more addiction right. So, you really wanna not be on these pain medications. Now, my problem with physical therapy and chiropractors is that a lot of times they can apply therapy that does not fix the underlying issue. So, chiropractors are very notorious for just, you know, adjusting a segment of the spine and creating some movement on that spine and calling it a day, right? But, if the person’s inflamed from their diet and lifestyle, that’s not helping it and also the soft tissue component should be addressed. So, when I was a chiropractor doing these kind of work, we would do like, percussion, I’d have a percussion instrument, just a couple of minutes to get the tissue warmed up and that way when I would adjust, I wasn’t having to adjust through all this soft tissue that was so hard, the soft tissue was more loose and I could move that segment and I’d always talk about how we get some better movement in the spine with exercise too because you wanna, you don’t want only movement in that spine to be through adjustment right? And so, getting these soft tissues under control using some active release techniques to help lengthen the muscle, help break up fascial adhesions, super, super helpful and so physical therapy, they’re notorious, oh I have knee pain, let’s just focus on that knee, maybe they do like an anti-inflammatory you know, uh, Russian stim or microcurrent or ultrasound, that’s good from an anti-inflammatory standpoint but physical therapy is common, we just only exercise that joint, we only stretch that joint, that’s it. They don’t look at the instability above and below the joints. Joints are very rarely just become unstable at that joint unless it’s an acute injury, someone took out your knee, it’s usually there’s instability either above and below so a good chiropractor, PT person will make sure the joint above and below is doing well. If I see knee issues, I’m gonna make sure there’s good glute activation, I’m gonna make sure that the hip flexors are facilitated, they’re not overly tight, I’m gonna make sure glute mi, glute max, all the adductor muscles in the middle are doing good. I’m gonna make sure the tip fib joint at the ankle has good stability. I’m gonna look at everything above because if there’s instability above and below that knee can compensate and have to work harder. So, I’m gonna make sure all the muscles around the knee, the glutes that stabilize the hips, the hamstrings that go to the glute that go up to the hips and also help stabilize the knee, the sartorius, the gracilis, semitendinosus, and semimembranosus, make sure everything is stabilized. 

Evan Brand: Yeah. You and I have coached many different, uh practitioners, a lot of them chiropractors and so many of them tell me, I’m just straight up sick of cracking backs for a  living because they know they’re gonna have to come back every week, they’re gonna crack the back again and then they’re gonna send the patient on their patient on their way and they’re never gonna get better and when I was working out of that brick and mortar practice and I started doing functional medicine consults, doing lab testing, getting all of the existing patients in the clinic, simply to make diet changes, it was funny but I guess not so funny for his bottom line, the chiropractor I was working for because, now instead of Betty needing to come in every week, she’s like no I’m fine doctor, I’m gonna come in in two weeks or three weeks or four weeks and it’s because the underlying inflammation was improving based on me fixing the gut, getting the diet improved. So, it’s kind of funny because people got in this routine of like, I’ll see you next Friday. It’s like, she shouldn’t need to be cracked again next Friday, you’re cracking her today, like what the heck.    

Dr. Justin Marchegiani: Yeah. It just depends how acute. If it’s an acute episode, you know, you’re gonna need to do it more frequently the first couple of weeks but if it’s more of a chronic thing, yeah you gotta get the soft tissue under control, or you gotta get the systemic inflammation in the body to the diet under control. And if you’re a chiropractor, you definitely wanna look at upper cervical, right, C1, C2, malalignments can create a lot of problems so that you definitely want to make sure that’s kind of crossed off your list because that can really cause a lot of issues and that could be a root cause as well but most people, it’s like poor posture, poor sitting, not enough movement, crappy diet, lots of inflammation and then of course, you know, muscles can also pull joints out of alignment too and cause them to feel sticky too. So like, I find the best chiropractor are like the applied kinesiology chiropractors because they would like use a percussion instrument even just for a minute or two is huge or they would do like origin insertion work, they would do like SOT technique, which uses blocks to get the hip alignment better I found those techniques were really helpful for chronic back issues and then when you have disc issues too, like you need to pump that back whether it’s a flexion distraction technique to help open up that disc, whether it’s an inversion table or whether it’s an inversion table or an inversion device for the neck that goes over the door or cuff to kind of create that negative pressure to pull that disc in off the nerve roots can be super helpful but then you got to get the muscles train down the road so a good PT or a good postural program like you can start with Eric Goodman’s foundation training. There are a couple of really good PTs online that are excellent, Bob and Brad, they go, they do a lot of nice postural videos at home stuff that are very helpful to people that are in pain. So, those are good guys, I’ll give them a, you know, a hot tip. Anything else you wanna highlight on the structural stuff we can go talk about the supplements next. I think that’s a good kind of ending point. Anything else, Evan? 

Evan Brand: Now, let’s move into the supplements, I had already mentioned like some of the enzymes, so I mean, we’ll use some of those and we often use these in combination, I mean sometimes people are taking so serratiopeptidase or I’m even personally doing lumbrokinase, I do a lot of lumbrokinase too because that’s like way more potent than serratiopeptidase and so we use that for blood flow problems with some sort of coagulation issue so whether it is an infection or mold toxin, Lumbrokinase, it’s a game changer.

Dr. Justin Marchegiani: But I want to hit that one. I wanna just hammer that one spot for a second. If you have poor blood flow which diet and infection can drive poor blood flow, if we can’t get the blood flow improve, we’re not gonna get the inflammation out and nutrition and oxygen in so ginger, the enzymes getting your diet under control, one of the biggest things that helps coagulation, if we decrease coagulation, we improve blood flow, we improve blood flow, we improve oxygen, we improve nutrition, we work on pulling inflammation out, that’s like a foundational mechanism to getting pain under control.

Evan Brand: Yeah. Well said. And there’s a lot of issues we’re seeing with post-viral coagulation issues or even acute coagulation issues, so make sure if you get some viral stuff going on, you gotta be knocking some if that too and we’ve seen people that are having chronic issues months and months later. So, to be honest in the time that we’re under I am personally staying on and recommending a lot of clients stay on some sort of enzyme just as an ongoing coagulation support, I think it’s a very, very smart insurance policy.  

Dr. Justin Marchegiani: Correct. And when we talked about these enzymes, for people that are listening at home, these are enzymes you take with food, we’re talking about enzymes we take an hour away from food on an empty stomach, you know, some of the best ones are gonna be the Lumbrokinase the nattokinase, the serratiopeptidase. Some are really good at taking them, um, enterically coated so they break down in the small intestine away from food so they get into the bloodstream. These enzymes can one break up scar tissue, they improve blood flow and they also can decrease a lot of interleukins and cytokines that are flowing in the bloodstream. So, if you’re chronically inflamed and you have a lot of these cytokines and interleukins in the bloodstream, these chemical messengers from inflammation, it can actually start to break them down a little bit, which is good. So, that starts to relieve pain. Now, if you get to the root cause, where you’re getting some movement, you’re working on your posture, you’re working on sleep and diet. This is powerful because now that starts to accelerate healing even better faster.   

Evan Brand: Yeah. And these are proteolytics so when you’re like researching these proteolytic enzymes as opposed you said the ones you’re taking with food are digestive, so they’re still called enzymes. 

Dr. Justin Marchegiani: Two different things and they cost a lot more too than digestive enzymes. They’re not the same price. 

Evan Brand: Right. Yeah. Like Lumbrokinase, I mean a bottle of it, retail on the one we use which is the Bolouke from Canada RNA. It’s like the best one, as far as I know right now. It’s like 98 bucks a bottle retail. So, it is pricey but man it’s incredible stuff, I mean in terms of hands and feet, my blood flow is incredible. That plus beet powder, which is maybe another thing I’ll go ahead and mention now increasing blood flow, I do like beet powder and I will use some of that supplementally. Yeah. Arginine, citrulline, I’ll take some those in liquid form and I’ll mix those together and drink it all down. Those can be very, very helpful. You mentioned ginger too, let’s talk about ginger because you’ve talked a lot about ginger for like nausea and digestive benefits but you and I were looking at some of the papers on it and it does have a lot of really anti-inflammatory benefits too. So, that’s kind of cool, we’re saying that it’s a digestive aid but also a systemic inflammatory aid, correct?   

Dr. Justin Marchegiani: Yeah. I try to add things into protocols that just have a wide net so I love ginger because (1) it’s a natural bitter, so it will stimulate digestive juices, (2) it’s an anti-inflammatory so it’s very calming, (3) it’s a prokinetic so it helps the digestive tract empty because if your have like some kind of chronic inflammation or gastroparesis, food and acis can sit in there too long and create burning, (4) it helps with coagulability so it helps with coagulation so it decreases it, so there’s less clotting so you improve the blood flow, it also helps with blood pressure as well. So, a lot of and then also it’s an antibiofilm, so if we’re using ginger, um, to help with like, you know, killing it, it can actually help strip the biofilm, which are the protective shields that bacteria use to prevent themselves from being killed so it helps with the biofilms which allows the herbs we use to be even better and again the enzymes we use also help with biofilms too. 

Evan Brand: Yeah. A cool study here was just saying that in rat models of liver cancer, ginger extract counteracted oxidative stress and inflammatory damage and it restored levels of superoxide dismutase catalase glutathione and prevented an increase in COX2, which is one of those pathways you and I were talking about that like some of the natural NSAIDs work on, ginger is basically a natural COX inhibitor. 

Dr. Justin Marchegiani: Yeah. It modulates, right? The problem with a lot of the COX inhibitor drugs of the early 2000s like Vioxx COX is called cyclooxygenase enzyme 2. That enzyme is also very important for repairing the gut lining and repairing the heart. So, if you block that all together like Vioxx did, you can destroy the heart and the gut lining, so with herbs it tends to more modulate not overdo it but bring it down in a modulatory kind of gentle way, kind of like an adaptogen works for adrenals and cortisol and stress. Shut it down but it pushes it in the right direction. 

Evan Brand: That’s an awesome way to think about it. So, ginger is an anti-inflammatory adaptogen? 

Dr. Justin Marchegiani: Yeah. Yep. 

Evan Brand: Pretty cool. Okay. Let’s hit the others too because there’s others we use in blends, how about some of the polyphenols like the quercetin, the rutin, the resveratrol, the rosemary. I talked about Japanese Knotweed earlier, the main benefit of the knotweed is because of the resveratrol in it.   

Dr. Justin Marchegiani: That’s Japanese knotweed. That’s very helpful. Yep. 

Evan Brand: It’s amazing for like rheumatoid arthritis, like I said Lyme type of arthritis, which a lot of RA probably is Lyme but it’s been not properly diagnosed. So, I love those. I personally take some sort of that all the time. You know, quercetin, I love too, it’s in the vitamin C family. I love it because it’s a great mast cell stabilizer. So, if you are dealing with mast cell activation in the case of mold toxin or Lyme or Bartonella, Babesia, Borrelia, Mycoplasma, any of these things, even viruses that are triggering mast cell problems and you have all this histamine out in your system, the quercetin is really gonna calm that down so that’s why I love it. And you can do too much of the good thing but in general something like 250 to 500 milligrams 3 times a day of course for me is a game changer. 

Dr. Justin Marchegiani: 100% I would say next, we could do curcumin much better off to take it liposomally that’s very important. So, liposomal curcumin also, you know, make sure you cut out nitrates, nitrates and of course grains and refined sugar can create joint issues, so you’d be surprised how many people that have many chronic issues just making those changes help. So, liposomal curcumin for better absorption. 

Evan Brand: Why the nitrates? Will you riff on that for a minute because nitrates..

Dr. Justin Marchegiani: The alpha-Solanines, their compounds, their anti-nutrients in the nitrate family, tomatoes, potatoes, eggplants, peppers, these alpha-Solanine can get into the joints and they can kind of create a lot of inflammation similarly with people that have oxalate problems. Oxalates can get into the joints. These oxalate crystals and create a lot of pain issues in the joint tissues, in the muscle belly too. Now, again, I don’t go into oxalate restriction out of the gates because there’s a lot of healthy foods that have oxalates in them. Spinach and green vegetables. So, if someone’s coming off of a processed food diet, the last thing I want them to do is not to be worried about oxalate because that restricts a lot of vegetables. So, I don’t worry about oxalates out of the gates if someone’s diet’s crappy. So, I would just, I would work on their diet very clean and then potentially in some organic acid test that we do, we could see if oxalates are really high. If do they have a history of kidney stone problems, those kinds of things are helpful.  

Evan Brand: Well, yeah, don’t forget to mention too, Candida, I mean we’ll see oxalate. 

Dr. Justin Marchegiani: A ton from a kid’s problem. 

Evan Brand: Yeah. So, I’ve seen people on like a low oxalate diet for years, they still show up off the charts and they’re having these joint pain issues, we simply just fix the yeast overgrowth or the fungal problems and then the oxalate markers go down and their joints are better. So, make sure that when you’re doing a work-up on these type of issues whether it’s mobility or pain or otherwise, make sure you’re looking for these fungal colonization markers, you’re looking at the Candida, you’re looking at some of the bacterial overgrowth because all of these things are gonna act as we’ll just say toxin in the bucket and if you get this infection plus that infection plus yeast then you really have much, much higher chance of having these problems and you go take the ibuprofen, you’re not knocking any of that stuff out. The yeast is still there.   

Dr. Justin Marchegiani: 110%. So, the oxalates, maybe more of a yeast issue, not necessarily an oxalate problem. So, something we add to our list, we can use, uh, things like Boswellia or Frankincense, very, very helpful, very good. Again, these things, how they’re working is they’re primarily modulating interleukins, they’re primarily working on cytokines, reducing some of these inflammatory compounds they may be working on the COX enzyme C-O-X-2, they may be working on nuclear factor beta, right? These are different inflammatory signals or chemical messengers, uh, may be working on prostaglandin E2, so they may be helping a lot of these things. So, we have to make sure if we use supplements though we’re not just covering it up like a band-aid, we’re actually trying to get to the root cause. So again, herbs tend to be better than like an ibuprofen long term because these things kill tens of thousands of people a year, not in the right way. Go look at Wolf et. al., 1998. New England Journal of Medicine Ibuprofen kills 19,000 people a year taken incorrectly. So, using these medications like Ibuprofen or NSAIDs in the short term may be fine, it’s the long-term use because you’re not getting to the root underlying issue. The nice thing is if you use the herbs and the natural things, long-term, there’s virtually no negative impact using those but again we’re not still getting to the root so use the herbs and the natural stuff long term to get to the root, get to diet things, that’s your best kind of foundational things. We can also add in some CBD oil, which is very anti-inflammatory. Anything else you wanted to highlight supplement-wise?  

Evan Brand: I would say magnesium would probably be one other one that’s located.. 

Dr. Justin Marchegiani: Great muscle relaxer

Evan Brand: How about, also, some of the herbal muscle relaxers too, I mean like Valerian and Passion flower, there’s some benefit from these. There is kind of a dual purpose, right? You could use it for sleep. Yeah, poppy would be good too. You could blend all those as kind of a sleep but also like a pain remedy and then I like topical magnesium also I love the Epsom salt bath. I like it more in a float tank though. I mean, Epsom salt bath, you’re like what a couple of pounds at most whereas a float tank, you’re getting 800 pounds, so just not eating.. 

Dr. Justin Marchegiani: I still absorb a ton though; I just do my fit. Just like a scoop or two but I still feel a huge difference but I agree if you can do the float tank, great, but if not that’s still a good in-between at home. Try it out for sure. 

Evan Brand: If I was like super stiff and I’m like my God, I can’t move, I’m going in a float tank because, I tell you I’m so flexible in there like when I first get in that so folks listening, this is basically like a large bathtub with 800 pounds of salt give or take. Super filtered water, it’s warm, it’s your body’s temperature, you take a shower, it’s usually at a spa setting, you get in there, you float on the surface of the water, you have your own little private float tank or float room usually and you’re just floating there and you’re there for an hour and your nervous system relaxes, they’ve used it for trauma and PTSD, so in terms of mental benefits, there’s incredible anti-anxiety benefits from it, but for physical too also, I tell you man, when I’m in there I fell, I mean, I feel like I’m made of jelly like, I mean I can just move so much better. One of my things. 

Dr. Justin Marchegiani: I would say, that, you know, from a nutrient standpoint amazing, a good myofascial release massage person, a good active release chiropractor, some kind of soft tissue technique, even if you’re doing, um, you know, foam rolling or get one of the hypervibe percussive tools at home. Just something to improve pliability, add in some of these nutrients that we mentioned CBD, curcumin, resveratrol, anti-inflammatory, I think also incredibly underrated collagen, I mean I do my true collagen 20-40 grams a day, um, collagen is a building block of your connective tissue that we don’t get a lot of because we’re not getting the knuckles and the bones unless you’re doing lots of soups with the whole carcass in there, we’re not getting these nutrients. So, adding extra collagen is essential for good building blocks or your joints and connective tissue.  

Evan Brand: I would agree. I mean, a forgotten nutrient that we just don’t eat in our diet, you can’t get that at a steakhouse, I mean, you’re just getting lean muscle. 

Dr. Justin Marchegiani: Unless, you’re getting bone marrow, unless they cut the long bone and they have all the marrow for you and eat that, that’s the only way you get it. Work in soup but most people aren’t getting it and so we’re getting more muscle meat, so that’s a good step out of the gates. I mean, I had my little coffee here, I had 30 grams of collagen this morning. People aren’t getting it. 

Evan Brand: Sweet. So, regarding 

Dr. Justin Marchegiani: A lot of anecdotes of patients, a lot of anticipations of just getting more collagen and changing their diet, huge chronic joint pain just shifting. 

Evan Brand: Oh, yeah. And yeah the diets used. So, yeah, I mean, labs, I mean we’re gonna look at stool, we could look at urine, we could look at blood too but you know but this is part of a work-up that we do, so if you need help please reach out. I’m sure we could get to something that hasn’t been found, I mean, even the Prevotella infection we look for in the stool like 75% of cases of Rheumatoid Arthritis are linked to in certain studies this Prevotella infection, which is the bacterial we test for. So, you’ve gotta look for the microbiome type issue, you gotta look for the deeper stealth infection issues, intracellular parasite type issues. There’s a lot of stuff too but we just have an approach to it, you know, we kind of peel back the layers here and we get to the root of it so if you need help, you can reach out. We both work worldwide with people via video and phone calls so you can reach out to Dr. J, it’s Justin at justinhealth.com or me, Evan Brand, evanbrand.com and like I said we work online so we’re very blessed to be able to help people in every nook and cranny of the globe and it’s a wonderful thing to be able to help people find things that they never found in 20 years of suffering and we just love to provide that, I don’t know, the pot of gold at the end of the rainbow, I suppose. 

Dr. Justin Marchegiani: 100% and you just mentioned some bacteria issues and different joint issues we know ankylosing spondylitis, which is an autoimmune issue that affects the lower back, your Klebsiella is a common bacterial imbalance, we’ll see affecting the lower back and causing AS that’s another issue, we kind of add to the list so very powerful. So, yeah, again evanbrand.com, justinhealth,com for me, we’ll put the list of recommended products and different herbs that we use in our practice clinically if you wanna support, uh, the podcast and support us, feel free click down below, look under the references and you can get all these things that we recommend for our patients and ourselves right down there. Anything else, put your comments below, we really appreciate you interacting, sharing with family and friends and most people that we interact with, we don’t even get a chance to see and they get benefit so we love to hear your stories and your success. Evan, anything else man? 

Evan Brand: Yeah. If you’re on apple either on Justin’s podcast or mine since we will publish these episodes on each other, make sure you give us a review, we would really love it on the apple podcast, it helps to keep us up in the top of the charts of health and fitness so we can provide real root cause functional medicine strategies, there’s millions of people out there suffering and maybe a fraction are gonna get to hear this so please sharing is caring. Leave us a review, tell us what you think the show deserves and we’ll love you forever. 

 Dr. Justin Marchegiani: Thanks guys. Have an awesome one. Take care. Bye. 

Evan Brand: Take care. 


References:

https://justinhealth.com/

https://www.evanbrand.com/

Recommended Products:

Magnesium Supreme

TruKeto Collagen

Trucollagen (Grassfed)

Enzyme Synergy

Organic Grassfed Meat

Audio Podcast:

https://justinhealth.libsyn.com/how-to-reduce-inflammation-and-improve-joint-mobility-podcast-359

Why Do I Have Low Motivation – Functional Medicine Solutions | Podcast #358

Motivation is the process that initiates, guides, and maintains goal-oriented behaviors. It is what causes you to act, whether getting a glass of water to reduce thirst or reading a book to gain knowledge.

In this video, Dr. J and Evan Brand talk about the physiological issues behind your decreasing motivation and the functional medicine strategies, hormones, and lifestyle changes you need to do to improve your mood and overall health function.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

0:00  Introduction
1:41  What are the root causes of low motivation?
4:14  The physiological explanation of low motivation
8:39  Functional medicine strategies to improve motivation
10:53 The role of thyroid function to your body’s overall function
16:38 Lifestyle upgrade to boost your motivation


Dr. Justin Marchegiani: We are going to be talking about motivation. Really excited to have a nice podcast on this topic. Evan, how we doing today this morning? 

Evan Brand: I’m doing really well. I’m feeling really motivated. Hence, this topic on motivation. You know, I look around on society and I just see the way that people carry themselves. You know, we’ve become so casual in terms of dress. I mean, when you see people that are just coming out at restaurants, they’re wearing Crocs and sweatpants and, you know, hoodies. People just don’t appear to take good care of themselves, in general. And maybe that’s different in other cities but even talking to people when I bought a sports coat. I talked to the guy at the suit store, and he agreed with me that over the last 20 years, people just become so casual. And with that casual dress, I think that changes people’s level of motivation. When I’m in sweatpants and a hoodie, I feel less motivated, and less ready to charge the world as opposed to when I have on even something like a polo. I think, maybe that’s part of it, but I know there’s a lot of chemical, neurotransmitter, and gut reactions, you know, better involved too. So, what do you think, I mean, am I, am I onto something with the clothing? Have you seen a change even in your lifetime with people? 

Dr. Justin Marchegiani: Well, I think people like, I talked to a lot of patients and friends and like, ‘oh you get to work at home and see patients all over the world. That’s awesome, that must be so easy to just kind of get up and get ready’. I’m like, well I still shower and kind of get ready like I’m going to the office anyway, I wanna look good, I wanna feel good, I wanna feel clean, I wanna feel fresh, plus I wanna be able to jump on a video or see a patient, I wanna have a higher level of professionalism on how I look. So, I do think there’s energy just like you said, in just that look in the park, dress in the park feeling good, right? I think that all helps. I think it moves the needle. That makes sense.  

Evan Brand: Well, let’s see some of the root causes of that. I mean, low motivation, in general, the first thing that I think of and maybe your average listeners thinking of, they listen to us for a while, they’re gonna think of dopamine. And that certainly one potential cause and we can measure that using urine organic acids testing. So, we’ll look at the markers for dopamine on that test that we can see, and I would say that 90% of people I test are pretty low and the other 10% are people that have Clostridia bacterial overgrowth. You and I have talked about this before, we did a whole show of Clostridia, I believe, but the mechanism is that if you have Clostridia which is a certain type of bacteria in the gut that will actually inhibit the enzyme dopamine beta hydroxylase and then you have this build up of dopamine. So, you have some of these mood issues that’ll happen because of your gut. So, if you fix your gut, that high dopamine markers normalize. But otherwise, I see, generally, pretty low dopamine and maybe you and I can kind of break down why is that happening. I think chronic stress is a big one. But I wonder if there’s a role of like excess caffeine, have you seen anything look like too much coffee, your stimulants depleting dopamine, what about drugs like the Adderall drugs, that kind of stuff.    

Dr. Justin Marchegiani: Yeah. I think we’ve, with motivation, it’s a couple things right. We have kind of the psychological kind of mindset aspect, I think that’s really important. So, I think number one, you gotta enjoy what you’re doing or you have at least kind of know what your talents or your skills that you’re at. So, you can work on doing things that one you enjoy and two you are actually good at. So, you can perform at a higher level, right? I think it’s a combination of those two things. And I think, also, there’s some people that what if you’re not good at things, right, so I think early on if you’re younger and you’re listening to this as you grow up, you really wanna look at developing talents. tacks and skills set. And you really wanna look at the marketplace and say, ‘where, um, where’s your gaps in the marketplace in regards to skill, whether on the health side or on the tacks side or on engineering. We really wanna look at where you kind of plug yourself into the marketplace, whether there are opportunities and then it’s also good to evaluate your kind of natural talents and skill sets. You kind of look at, you know, what people tell, I’ve always told you good at. There’s different tests out there whether it’s a Myers-Brigg personality test or, uh, I think another test out there called DISC, D-I-S-C test. There’s different tests out there that kind of help you understand, kind where your natural talents are at and then also just really observing and being aware of what you really enjoy doing. Usually, things that you enjoy doing, tend to be better at it because you don’t mind working harder at it. I think those are important, so then when you start doing things, you’ll really enjoy it. Now, on the physiological side, chronic stress well either acutely raises cortisol all over time. That cortisol can become lower which can affect energy and mood and cause your body to break down faster. And of course, that same level of adrenal stress can also lower dopamine, lower adrenaline which can then affect focus and motivation at a biochemical neurological level too. So, I think it’s good to look at both of those, so we can test the adrenal gland and know what’s happening at the adrenal level. We can also look at the neurotransmitters, the organic acid testing and look at various metabolites for Homovanillate, which is a metabolite for dopamine and then Vanilmandelate, which is a metabolite for adrenaline. We can get a window and into both of those metabolites and see how the brain is functioning on the inside.  

Evan Brand: Yeah. That’s a great point. People that are just doing stuff that they don’t enjoy, I mean, how are you gonna be motivated for life if you make up, you don’t enjoy it. I talked to a guy who picks up our garbage and he loves it. He loves his job. He loves driving around with a big truck all day and he makes a great money doing it. He’s happy. So, some people are gonna look at that and say, ‘oh, this garbage man, what a terrible life’. And some people, they enjoy it. So, I do think ultimately as they say if you love what you do, you’ll never work a day in your life. I still love what I do but I still, I feel like it’s still work, I mean, I enjoy it but when I’m away for too long on vacation, I don’t enjoy this much. I rather be working, I really do. I love helping people. I’m really addicted to the hustle and grind of helping people feel better. There’s so many people suffering. For you and I, I think, we’re in a good spot-on loving what we do, but then on the brain chemistry side, I would say that I certainly struggle on. I had gut issues, I certainly struggled with low energy, and partly low motivation and low focus and for a period of time I had trouble reading certain books, like my brain, I just couldn’t process. I had to read, read certain phrases or if someone said a phone number to me, I couldn’t remember just a simple 7-digit phone number. So, I definitely had some brain fog associated with gut issues. And on paper, my endorphins and my dopamine were a bit low. So, I think looking at these mechanisms, I would say Candida, something we could mention too because we know Candida produces acetaldehyde, which is kind of similar to an alcohol molecule and so some people are a little bit drunk on their own Candida overgrowth. So, if somebody that has a lot of sugar cravings or if you have a white coated tongue or if you tested positive for Candida on urine, organic acid, stool testing, we gotta fix that Candida because that’s directly gonna impact your mood, your motivation and your focus. 

Dr. Justin Marchegiani: 100% Now, I work with patients, right? And I look at a lot of the physiological imbalances. So, let’s say there’s hormonal issues, let’s say it’s a female, it’s estrogen dominance, right, lower progesterone, estrogen out of whack, there’ll be a lot of PMS, mood issues, irritability issues. They’re poor energy because of chronic adrenal stress, they’re not digesting their food well. There’s a lot of mitochondrial imbalances, B-vitamins, CoQ10, L-carnitine. You know, it’s hard to be motivated when you have a lot of these physiological imbalances, because it takes fuel to run this system. So, when I look at patients, I get them motivated to fix these things. You know, it’s hard to get someone motivated to just fix their mitochondria or fix their adrenals. So, I always look at, hey what are these health challenges that you’re having right now. What is preventing you from being, doing, or having in your life right now? Like, what do you want to be doing, being you’re having in your life that you’re not able to because of your energy or because of your chronic digestion, because of your, um, mood issues? What is that? I try to get really clear what those things are because if I can figure out, hey, we’ll it’s affecting me for working out whole day, it’s affecting me, um, being able to spend quality time with my kids, then we can lean on, okay we are gonna make these diet changes, so we can help you get back to spending better time with your kids or so we can have you focusing and doing better at work at closing deal, whatever that is. So, if we figure out the why, then we can lean on that why to get people to make the right changes because it’s the really the why is the essence of it. And that really helps to get people motivated. So, there’s the mindset motivation and there’s the physiological biological biochemical side. So, we wanna work on both. So, when I tell people to make these diet changes, not just making these diet changes, we’re gonna do these so we can help move the needle in this area or that area. So, it’s kind of like using psychological tactics that help keep your patient motivated. It’s also important.   

Evan Brand: Nice. That’s really a good point.  We have some part of our population, where there are just biohacker people who wanna see the numbers, right? They wanna see the numbers get better, and they’re happy enough to see succinic acid go from a 24 down to a 5. And we go okay, great we had major progress, the mitochondria look better on paper. Some of our people, they’re cool with just the numbers, but I agree with you, you gotta bring the emotional piece to. It’s not enough to say, ‘hey, I wanna get your dopamine higher because I want you to have enough energy to get out of bed, make your bed, get dressed, wear something nice, get to the office as you close the deal’. There’s a whole symphony of emotion and the neurotransmitter, the mitochondria, the adrenals, all firing together to make life nice and make life enjoyable. And I just see that the number one leading cause of disability in the U.S. is depression and so, I don’t know, I just feel like there’s so much on top potential, on top productivity out of the population, if we can just simply get the gut improve, get the mitochondria improve, get the neurotransmitter improve. I mean, we could totally transform the country. 

Dr. Justin Marchegiani: Yeah. I totally agree. I mean, I think simply, out of the gates, it starts with food. So, it starts with high quality food, organic, right, low toxin, eating good proteins, eating good fats. I think being more of a fat burner for most people is super important because we just tend, if you just look at micronutrient trends over the last 56 years, we just consuming more processed carbohydrates and of course the fats are shifted to more, kind of polyunsaturated omega-6 kind of vegetable oil. I think number one out of the gates is we switch to higher quality, better, more stable fats whether it’s on the grass-fed meat, high quality fish or if we do any plants it’s gonna be more on the mannose, right, olive oil, some avocados, those kinds of things. That’s important on the fat and then we try to restrict the lot of the refined grains, refined sugar and that’s some kind of first step and make sure that the quality there. in regards to organic, um, no added hormones, some things like that in the pot. That’s a good start for anyone right there. And then from there, we can look at the different hormonal systems. So, if we have chronically high cortisol, usually that’s more of an acute thing but that can cause anxiety, that can cause irritability. Usually, there’s a tire of wire that kind of thing there. And then of course as we have chronic stress, that adrenal pattern can move more to a lower cortisol stay, and that can cause energy low motivation low mood. So, we wanna really look at the adrenals. They’re part of that stress handling system. So, when we look at things that drive the adrenals its physical, chemical and emotional stress and so we wanna make sure there’s nothing on the emotional side that’s driving a problem, right? Marriage issues, kids issues, financial issues, whatever that is, we have to make sure, we’re at least addressing it and it’s in our forefront, we’re not just kind of putting your head on the sand. Physically we need to make sure we’re not overexercising or under so we’re getting some movement or we’re moving our muscles or we’re not overly sedentary, we’re not doing things that cause us pain, right? So, that’s important. Of the chronically in pain, we see a soft tissue person or a chiropractor to really get to the root of that. And of course, what we really focus on is the underlying hidden chemical stressors, that’s just the food sensitivities, the gut imbalances, the dysbiosis, the leaky gut, the hormonal imbalances, the low thyroid, the adrenal imbalances, the hormonal issues, um, the mitochondrial dysfunction, the toxicity, mold, heavy metals, right? So, this is where we, we come in there, we focus on the chemical stressors that play a major input on the adrenals and we chronically stress the adrenals, adrenaline is also produced by the adrenals to kind of get cortisol mobilize and chronic adrenaline stimulation will pull dopamine because adrenaline is a post cursor essentially to dopamine. So, it goes dopamine 🡪 adrenaline. It’s over chronically sti, in a stressed-out state. Your body will make adrenaline and will pull from dopamine to make adrenaline. And dopamine is important for that I love you feeling, it’s really important for focus, dealing with stress and staying motivated. So, we have to get that, the underlying reason why we pullin’ out that dopamine downstream, we have to get the adrenals fully supported.   

Evan Brand: Yeah. Well said. I’m glad you mentioned heavy metals too. I mean, people and their brain issues could simply be related to mercury toxicity. If you’re someone just walking around and you’ve got a mouthful of amalgam fillings, we know those are estimated 50-ish percent mercury give or take and we know that mercury directly affects dopamine. If you simply just type in, mercury and Parkinson’s or mercury and Alzheimer’s. There’s a lot of links to these toxins and brain neurodegenerative issues. So, if you’re somebody who’s just so poor motivation and it’s more on the extreme side, you might get this amount of amalgam out of your mouth. And for my grandfather, he’s pushing 80-years-old, believe it or not, the local, biological then said he’s already having memory issues, it’s too late. The issue of pulling out the mercury could create more problems. He just said, leave it alone. But if you’re 40, 50, 60, 70 maybe you’re still at that age where you can start working at heavy metal detox, maybe you’re using some sort of binder for the meantime but ultimately, you’ve got to remove the source. So, I mean, if you got heavy metal in your mouth, no matter how much chlorella, charcoal, or clay you take, you’ll still get metal on your mouth. So, that could be a huge issue for your motivation and you gotta resolve it. 

Dr. Justin Marchegiani: 100% out of the gates. Also, low thyroid can be a thing. Low thyroid can affect mitochondrial function. It can affect mood. It can affect energy. Obviously, thyroid hormones play a major role in your overall metabolism. And if your metabolism is low and slow or more than likely your motivation would be low. So, it’s really good to look at thyroid function. Now, if you go to your conventional doctor that just gonna look at TSH typically and again if your TSH is overly high, let’s say greater than three and a half four. You know, that’s probably be pretty good sign. There’s probably thyroid issues downstream happening with T4 being on the lower side or T3 being, let’s say, below that 3.0 marker in the United States metric. Um, but again, TSH may still be adequate, let’s say below three and you may still have problems with thyroid hormones downstream, with T4, with T3. Maybe there’s an elevated antibodies because there’s some autoimmunity. It’s kind of like smoldering there. So, you really wanna look at running a full thyroid panel and your conventional medical doctor would typically not do it. So, you gotta reach out to kind of more natural, functional medicine first to do it. So, if you guys want to get that kind of testing done, Evan and I, we all do that testing. So, evanbrand.com, justinhealth.com. There’s links there where you can work with us if you want that type of in-depth testing. But low thyroid can be a deal breaker and it can, in most thyroid issues are autoimmune. So, you have to fix the gut. You have to fix the food. You have to fix all of the digestive issues to really get that usually under control. 

Evan Brand: Yeah. Good point bringing up thyroid. So, I’ll bring up another kind of related one which could be anemias, right? If you got low ferritin, for example, you’re gonna be so exhausted if you have some type of anemia that that’s gonna really affect your motivation as well. So, I get kind of annoyed, to be honest with you, when I see people posting these motivational tracks. It is usually some super fit dude, possibly he’s on steroids, he’s flipping a tire and then yelling over the microphone, and it’s like, ‘you gotta get up and you gotta just do it’. And it’s like, you can’t just do it, like, I love that you’re, you know, 28 years old or maybe you’re on growth hormone and you’re flipping this tire and you’re motivated. But that type of talk goes only so far. And from our functional medicine mindset, like I said, I kind of get annoyed, because then you have this woman, maybe 50, 55 and she looks at herself in the mirror and she’s not happy on what she sees. She got insulin resistant, the diet is not dialed in, the guts affected, the neurotransmitters are low, but mitochondria are damaged because she got exposed to, uh, tick bites and molds. This motivational dud ranting over the microphone, he does not have a friggin’ clue about any of these functional strategies. And so, people then think that motivation is just this simple thing that you could just turn on or turn off. If I could just give motivated, I could do this or that. And it’s like, look, it’s way deeper than that, it’s way deeper than this dude just giving you some hoorah jumping the CrossFit class. And that’s why, that’s all this day. 

Dr. Justin Marchegiani: Yeah. I’m not a big fan of RAW, RAW stuff because it ignores physiology. I mean, I think there’s the RAW, RAW stuff can be helpful if it shifts your mindset. But mindset cannot be overcome physiology in the long run. It’s like people gonna, uh, an Anthony Robbins, I think Tony Robbins is great, he has a lot of strategy mindset stuff but you come out of this event so motivated. And it’s like, now what, right? It’s kind of like you’re driving your car, right, your old, used car, nothing’s wrong with it but your own E. Some guy comes up next to you and in like a Ferrari and it’s like, ‘man, you just got hit the back gas pillar, go’. And it’s like he hits the gas pillar, he’s out of sight and you’re like, ‘yeah, I don’t have fuel in my car and I kind of force cylinder under horsepower car, yeah I can’t do it. So, the first thing you gotta do metaphorically is you have to fill your tank of a gas. Get the car, get the gas in the tanks if you have fuel. And overtime, upgrade your car, upgrade your health, right? And we start with food quality, we start with good fats and proteins, we start with addressing glycemic issues, not overdoing or removing the processed sugar and the grain, dialing in the carbs on what you need, sleeping better. That’s like trading in your car at the car dealership, right? Literally, just by doing that, you’re starting to upgrade internally and of course from there we can always go down the functional medicine path and look at these hormone systems, adrenals, thyroid, gut function, mitochondrial issues. But we can at least upgrade the car and the fuel by making these simple lifestyle choices that are free and then from that, that gives you more motivation, now you have more energy, now your brain is clearer, so now you can, you know, be clearer on what your goals are. You can get very motivated, you can set timelines to your goals, right. What’s the difference between a goal and a dream? A goal has essentially a dream with an endpoint, a timeline on it, right. I’m gonna achieve this point, right? Take your dreams, make it your goal by putting an aid on it and some action items to go on it. And that takes energy and focus. And if your brain is foggy and overly tired, that’s gonna be problematic. So, I think, just work on those simple things and then once you get a little more motivation there then what’s next. And so, the things that I looked at when people are stressed and depleted, brain inflammation plays a major role with low motivation, so if we can cut out the foods, if we can add in B-vitamins, B6, magnesium, good health omega-3 fatty acids, that’s gonna help with the brain inflammation. That’s gonna help with the neurotransmitters. And then from there, we’re gonna look deeper at the box. This could be SIBO, bacterial overgrowth, H. pylori, parasites and getting the gut really cleaned out is gonna help shell out a lot of the brain inflammation because inflammation is bidirectional. Inflammation in the body can make its way to the gut and create a problem. Inflammation in the gut can make its way out of the gut into the bloodstream by leaky gut permeability causing inflammation in the brain. 

 

Evan Brand: Yeah. Well said. We could start to bring in some of those vitamins, like the omegas, we can bring in some phosphatidylserine or phosphatidylcholine, we can bring as you mentioned the B-vitamins, maybe some Ginkgo, possibly nootropics like the racetam family, pretty common phenylpiracetam or others oxiracetam. A lot of nootropics out there that you could use, but there’s so many people like in the that they’re taking these different nootropics but they’re not addressing anything in regards to their gut or anything, whether hormones. So, I think it’s… 

Dr. Justin Marchegiani: Yeah, I have a product in my line could, Dopa Replete Plus which has tyrosine and will have an actual pure L-dopa. That’s a good one. Or someone’s coming out of the gates, I would just even just be using pure tyrosine, pure L-tyrosine with some high-quality B-vitamins can be really helpful because you need the B-vitamins as a cofactor to really help convert to some of these neurotransmitters, some of these amino acids to become the actual neurotransmitters. 

Evan Brand: Yeah. You can feel it pretty quick. I mean, that’s the cool thing about amino acids, is that you mentioned. A lot of times, you know, when we pitch people our services, we’re like hey, sign up, you know, give us a call evanbrand.com, justinhealth.com. People haven’t, they haven’t enough motivation to be miserable to do that. Sometimes, I don’t even think about people, they know they want to help but I think they haven’t enough motivation to even call us and reach out to us. So, if you’re one of those people, we’re here but, in the meantime, yeah, maybe you use a little bit of tyrosine. It gets you motivated enough to even reach out to get further health because I think a lot of people get overwhelmed at what’s gonna entail in regards to diet changes. Like, oh, that’s overwhelming, you’re gonna make me cut this out, lifestyle changes, you’re gonna make me cut that out, like oh my God or now I gotta go to bed at 9’oclock, you know, that’s too hard. So, we used this little tool, this functional medicine tool to help motivate people to get them through the protocol. Because you and I could design a perfect protocol, mitochondrial support. We’ve got the gut dialed in. We’ve got the detox, the binders. We got the liver, the gallbladder, the adrenals. It’s all taken care of. But, it’s only if somebody follows through so then you get to the part of compliance which we could do part 2 on that of you want. Like, how do you stay on track but making the plan and getting the labs is the first step and getting the people to follow through is the second one. I think progress ultimately gets people going, because they’ll feel how much better they are but somehow, so, what we’ll use somebody’s brain nutrients just to get them off to get through and follow through.

Dr. Justin Marchegiani: Yeah. From a mindset perspective, it’s kind of like if you have pushed a car before right. You push the car. The hardest thing we’re pushing a car is overcoming the initial inertia of the car, from not moving to moving, right? That’s the hardest part. And so, when we’re dealing with people’s health inertia, it is just getting a couple of habits of moving in the direction that allows the car to start moving. Now, the amount of energy you need to put into that car to keep it moving is far less, right? It’s far less because you overcome the initial inertia of it being stock to moving. That’s kind of health is. You kind of make like a couple of small changes now’s the ball’s rolling and then now you can add, you know, you just can sleep for a little bit, add a little movement in there, and a couple of supplements and now we have a lot more now it becomes even easier to keep that going. And then of course, the key is now, okay, all the energy going into it was moving to the four steps of learning right. It’s unconscious incompetence, you don’t know what you don’t know. Now, you’re consciously incompetence, you know what you don’t know, you’re at least aware of these things. And then you go from step 2 to step 3 you’re consciously competent, someone’s helping you but there’s a lot of energy to keep doing the right things and then ideally you start to move into the level of unconscious competence where it’s automatic, right? It’s like someone who drives a standard transmission, everyone who’s done that they know, like, they’re starting on doing clutch, shift, what, their heads going down looking at the gearbox to stir up. It’s tough, right? But then eventually it’s like, clutch, shift, 1,2, 3, right? It’s easy, downshifting no problem. You don’t have to worry about it, it’s like you’re in automatic transmission because you get the whole thing. So, that’s kind of, well, where habits are, you just start with the ones that really bears the most fruit and then you go up from there. So, that’s kind of kind of look at out of the gates.     

Evan Brand: Well, look, you just did a live on camera because you’re like oh, we’re talking about in that booby. Whip up a capsule, and then boom you pop your aminos just like that. That’s kind of how I am too with protocol, I mean I’ll just feel how I am; I need a little bit of this, a little bit of that. And I’m just consciously making these micro calculations throughout the day. Oh, little low heat, op stressful day, hit the adrenals a little harder.  We’re constantly making these twigs, it’s just a really good place to be. 

Dr. Justin Marchegiani: Yep. I’m gonna go hit some push-ups and some kettlebells, wings, and a little bit of rowing here in a minute. And I’m gonna, um, you know, use some. So, I just try, you know, surround myself with good tools that I could plug into throughout the day to keep that momentum going and then, you know, foundational things, food, water, sleep. So just make sure you, and then of course you can plug in some movement along there right. Those are your three to four big check marks that you gotta hit during the day. And as you start getting that, you can build up from there and that gets you that foundation you need.  

Evan Brand: Yeah. Sleep is huge. So, we’d done a podcast on that but we’re always happy to do more. So, we’re wrapping out for now though. People can reach out if they need. We work around the world via facetime, uh, zoom, skype, you know, phone. We can do. We send labs everywhere and you can reach out to Dr. J at justinhealth.com and you can reach out to me, evanbrand.com and we’re happy to help. And we’ll look at some of these things and we’ll help investigate what could be going on, why’re you struggling. We know that you wanna get that dream business that dream goal, but you gotta make that a reality by optimizing these systems. So, that’s exactly what we do on ourselves on a day-to-day basis. Just literally just boost these neurotransmitters as we’re talking here. So, once you get these tools and place, you’re just gonna be driving, you can take over the world if that’s what you want.

Dr. Justin Marchegiani: 100% evanbrand.com, justinhealth.com. We’ll put links and recommendations for different things that we talked about product wise in the description of the video. Evan, awesome chat with you as always, my friend. We’ll talk soon.

Evan Brand: You too man. Take care. 

Dr. Justin Marchegiani: Evan and I, we’ll go now. Bye-bye.

Evan Brand: Bye-bye. 


References:

https://justinhealth.com/

https://www.evanbrand.com/

Recommended products:

Dopa Replete Plus

Dopa Replete

Iodine Synergy

Thyro Replete

Adrenal Revive

Adrenal Boost

JIH Thyroid Advantage Panel

Dutch Adrenal Test

Heavy Metal Clear

Heavy Metal Test

Audio Podcast:

https://justinhealth.libsyn.com/why-do-i-have-low-motivation-functional-medicine-solutions-podcast-358

 

Why You Can’t Put On Muscle – Functional Medicine Solutions to Avoid Being Flabby | Podcast #357

For most people, Dr. J and Evan state that most of the end goal is to build muscle and tone up. While you may have done your research and watched plenty of workout videos online, many still make a variety of common mistakes that can lead to hampering gains and slowing down their progress.

It would help if you also had protein which contains amino acids, the compounds that help build and repair muscle tissue. While cardio is essential, too much of it can also harm you and possible lack of sleep. Moreover, Dr. J and Evan emphasize that monitoring your diet or food template is vital in the entire process.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

0:00 – Introduction

1:53 – The role of protein and diet in building muscles

5:31 – Helpful exercises to stimulate muscle building

12:12 – The gut connection of a flabby body

18:04 – The effect of too much sugar and carbohydrates in muscle growth

30:56 – Helpful strategies and lifestyle modifications to boost muscle growth


Dr. Justin Marchegiani: Today, we’re gonna be talking about putting on muscle mass, how to avoid being flabby. We’re gonna be talk about digestion, exercise, being able to absorb and break down protein, also you can work on helping to be, you know, strong, functionally strong, lean, etc. we’re really excited to dive into today’s topic here. Evan, how you doing man?

Evan Brand: Yeah, doing really well and you guys asked for this. We didn’t just come up with this how not to be flabby topic. You guys said this during many so much consultation that Dr. J and I had done personally with people that’s what women say. So, were gonna address that. They say, “I’m flabby and I don’t want to be and what do I do about it?” And if you were to ask like a conventional weight trainer, bodybuilder type person, they’re gonna tell you to probably eat more calories and just work out more harder. And most of the people that have come to us, they’ve already been down that rabbit hole and they’re far more symptomatic and sicker than at the level of where they can just try to hit the gym harder and that’s really to me not the answer because I’m lean. I stay lean. Now, granted I’m not a 50- to 60-year-old woman that has this particular issue, but I don’t have any sort of issue to where I feel like I need to eat less. I don’t count. I don’t measure. I don’t think any of the women and men even listening or watching this, I don’t think you need to count, or measure or weigh. I mean this food obsession. Our ancestors didn’t do this. They’re not out in the past year in, you know, native American times looking at the bison and saying, “oh no, that’s my two ounces of beef, I gotta stop” or “my bison, I can’t go beyond that four-ounce portion that’s too much”. There’s deeper root causes like estrogenic compounds in the environment and mycotoxins that effect your leptin receptors and create this fat storage mode so there is some more modern toxin issues that hopefully we can dive into today.  

Dr. Justin Marchegiani: Yeah, absolutely. So, first thing out of the gates, we need to make sure we’re consuming enough protein. That’s really important. So, protein is essentially the building blocks to help out put on muscle and to keep our body strong and so what’s kind of the general sliding scale. Again, it depends upon how much you’re wanting to exercise, what your goals are right. So, as a female, you’re not gonna just be able to hit some lifting and then get overly bulky, it’s just not gonna happen. But, kind of general scale is about half a gram to one gram per pound of body weight is a pretty good rule of thumb so if you’re a guy like I’m six to 215 pounds, I would probably if I wanna really get bigger, I need to be doing at least 200, 230, you know, grams of protein per day, right? Typically, I’m at about .6 to like three quarters a gram per pound of body weight, so like maybe around 150 grams. I’m usually about 5 – 6 ounces of proteins per meal and so that’s kind of where I need to beat at one protein is very satiating, I’m making sure, I’m consuming fat with it, so, then it’s stabilizing blood sugar. It’s providing a lot of amino acids which are, you know, important for brain chemistry, blood sugar stability, mood. Also, adding fat with it which one fat tends to have good high-quality cholesterol from animal products, so, that provide building blocks for hormones, fat soluble vitamins, really good nutrients. And from there, your carbs are going to be dialed in based on your activity levels, that’s where more starch, if you’re more active, if you are pretty lean, you could probably handle more starch. If you’re carrying extra weight, you want to mitigate the starch, go lower on the starch and focus more on non-starchy vegetables, maybe a little bit of low sugar fruit and kind of time that up. The next thing is stimulus. You’re gonna need to more your muscles ideally and it’s not have to be a crazy amount. It depends on your goals are. If you’re just a woman then you wanna have your muscles just feel solid, that could be something like Pelatis, where you’re doing body weight or cable movements, you know, typically finding a movement where you could do about 12 to 15, as a female, reps, um, with maybe 1 – 2 reps the tank. And I like, 1 – 2 reps in the tank, just because it makes it so you’re probably gonna hurt yourself. The more skilled you are, the more you can go right to failure, that’s better. The less skilled you are with the movement, if you don’t have a good trainer watching you, you know, probably leaving one to two reps in the tank will help prevent you getting injured. But, just recommend starting with push-ups with good full-range push-ups. I like having a borrowed push-up because I can go deeper which is great, my face won’t hit the ground, right, so I can go deeper, go all the way down and then go all the way up, so full range. Here, you can get a TRX which is a suspension trainer, put it in the door jam, I have one over here in my gym and you can do a full range pull so you’re working in the push, pull, and of course you can also do, uh, Lat pulldowns like this, or hands facing to you, so pull up, chin ups in the face, do more of the Lats, yeah, chin ups, more Lats, pull up is gonna be more biceps. So, you’re working, trying to work every single range that comes at you and ideally with the pull up you could get some elastic bands that hook around your bar and that go around your knee that gives you that little extra push. So, the key is just to find simple movements that you can do to failure plus or minus 1 or 2 reps in the tank. That’s a really good stimulus out of the gates and the next thing is really dialing in the protein, so we talked about amounts there and then we can go other things like digestion and other gut issues that could be impairing that protein absorption later on. 

Evan Brand: So, I can hear a woman saying, “you’re nuts, I’m not gonna do a pull-up, there’s no way I can do a push up, I’m not anywhere close to that fitness level”. And I would say, if you’re not, if you do have access to a gym, if you’re into a gym, I’m not anymore, I used to have a gym membership, I don’t need it anymore, I’ve got a good setup at home, so I feel like I’m great without it. But if you were to have access to a gym even for 10 bucks a month. There’s a lot of good ones like planet fitness that are out there now to where you can do some of these assisted like, uh, type exercises where they have assisted pull-ups or they have like assisted, uh, dips where you have weight that literally pushes you. It like, if you weigh 200 you add 50 pounds that it’ll make you feel like you weigh 150 and you can start there. So, you’re really starting with like a negative weight of your true weight. So those machines are available if you could feel like you’re just so out of shape, you can’t even do one push-up or one pull. And you can just go on your knees too, I mean you could start out push-ups on your knees as needed. You gotta find people, where they’re at. So, if you’re like, ‘man I’m too discouraged, I can’t do a freaking pull-up, I give up, I’m not doing anything’, you don’t have that attitude about it and if you could have one piece of equipment, I mean, I gotta say I love the row machine, I’m glad you got one too. 

Dr. Justin Marchegiani: The roller is lovely machine.   

Evan Brand: It works your legs, it works your arms, it works your backs, works your arms, your traps. I mean if I could take one thing to an island, some are gonna argue with kettlebell, which probably is more functional, but in terms of enjoyment, I gotta say, I really enjoy and love the rower and I still think, there’s a place for kettlebells and dumbbells, I mean those are awesome, universal things. But for women, that and, and I just know this based on personal experience. Maybe younger females are not gonna be turned away. But I can tell you, if I try to take a kettlebell to a 70-year-old woman, she’s not gonna be interested in swinging that thing around. She’s gonna be worried about hurting her back or swinging the wrong way and it’s a lot more intimidating than sitting down and just simply rowing. So, this is hard to give one universal prescription because there’s different people listening, but I would say rower is very easy, low impact on your joints and not intimidating at all.  

Dr. Justin Marchegiani: Yeah, and then what’s the name of the rower that we have? 

Evan Brand: It’s called a concept 2. 

Dr. Justin Marchegiani: Concept 2. Yeah. I think I have the D. You have the D as well? 

Evan Brand: Yeah. I think, yeah. I think the D is, there’s a little different but yeah concept 2-D, it’s a rower. It’s vey very sturdy. You get what you paid for. So, it’s around a thousand bucks but it’s worth it.

Dr. Justin Marchegiani: It’s worth it, you could stand it up, so it saves a lot of space too. Yeah, I like that more for my interval stuff, so I’ll do a 30 sec on, 20 sec off, I’ll do eight sets of that. That’s gonna be more of like high intensity, just really good cardio interval stuff. I like that, just for keeping metabolism up, keeping the body a little bit leaner and more functional. I like the fact that you’re doing something that’s on the cardio side that’s putting you more into extension like this and you’re using your hamstrings to pull yourself as you slide right back and forward, you’re using a lot of your hamstrings and then a lot of the back where a lot of cardio stuff like, you know, whether it’s a bike or you’re on Peloton or you’re on elliptical, you kind of hunched over in this flexion position. I love the fact that you’re opening things up and extension. So, I like that. That’s good. That’s definitely on the cardio side. Now, like Evan talked about earlier like, easiest thing out of the gates a TRX suspension trainer is great because you can just change the angle in which you’re at so like, if here’s the suspension trainer hanging, and if I’m like at this position, this is going to be, meaning I’m flat with the ground, I’m like a 90 degrees angle from that suspension trainer, that’s gonna be the hardest. So, you can always just change it so you’re at 45 degrees or less. It’s like the equivalent of like kneeling or doing a wall push up, right, the angle is less, um, less perpendicular, therefore you’re gonna have less force, so you can always just do a TRX trainer and just change the angle so that push up or pull up is gonna be less and then in between you can also even do cables, whether you have cables at a gym or you can get some flexible bands that either wrap around like, um, like let’s say, I have a big, um, squat bar, so I’d wrap it around that and so it would be behind me like this and I would do pushes like this where I could do pulls like that, that’s great. Just, if you’re wearing, if you’re doing cables, if it’s not fully secure, I do recommend wearing safety class. People have gotten those things that have snapped and hit you in the eye, you can get some safety ones that like have like a little protective, I wanna say, like a wrapper around the cable. So, if it does break, the wrapper prevents it from whacking you in the eye. Does that make sense? So protective band or really kind of a safety-based cable that’s not gonna break, um, if it does it won’t whack you. So those are good options for you out of the gates for stimulus, because you need to have the stimulus, right? Push, pull, right, pull in the vertical motion, you can even do a row in that motion, uh, you can do hip extension movement which is the easiest thing there is gonna be like a kettlebell swing, that’s gonna be easy or some type of a deadlift, right, it’s gonna be really an easy one there out of the gates. Anything else you wanna say about just the lifting? I recommend just, kind of, keep it simple. Do primal movements that are just gonna one put resistance in that plane of motion and just work within that, plus or minus, you know, 1 – 2 reps of failure. So, you’re not gonna hurt yourself but you also feel a little bit fatigued the next day. 

Evan Brand: Well, just simply moving throughout the day, I mean a lot of people are listening right now, they’re sitting at an office chair, they’re sitting in their car, you and I are both standing up, right now and we both do stand and sit. Sometimes, I’ll put my desk on the very lowest setting to where I’ll just literally be on one knee, like proposing and I will work on one knee for a little while. So, you and I are doing something very unnatural and many people are listening, we’re looking at screens and we’re, um, in a box working on a computer and so that’s very unnatural. So, I try to counteract that as best as I can by trying to either do the row machine on my lunch break and go from sitting to standing to kneeling and just try to do these positions. So, people listening, I’m not saying you gotta stand all day, I did that for a while, they hurt my back, so I think too much of one thing is not good either and if you’re a woman you’re in an office and you’ve got high heels shoes on, you’re trying to do it, obviously take your shoes off, try to go barefoot, you can get a really good like silicone, like rubber mat that they use for like washing dishes at the same time. Yeah, like an anti-fatigue mat, I mean, I would do something like that. These are the simple strategies. Now, would it be more optimal to be out in the sunshine all day, mostly skin exposed grounded, walking the beach 2miles a day and eating grass-fed meat all day and you know having, you know, handsome men, like wave banana leaves and keep you cool. That’d be awesome but people still have to work so I think you’ve got to work in some of these functional strategies with your normal real life. And then let’s go into the more, I guess you would call it nuance but really more of the deeper root causes because I’ve had people lose 50 to 75 pounds by changing nothing in regards to diet and nothing in regards to fitness. These were people that were relatively active. These were people that already had their diet dialed in, they were mostly animal based good quality meats, doing fine on the protein and the fats but they had these other root cause issues and I’d say that the first place would be to go is the gut and you and I have talked about this in other aspects but in other podcasts too but the gut can really be a big place where you gonna become flabby and this is really due to the recirculation of toxins, when you have bacterial growth in your gut, which is an extremely common thing, this is not rare. When you have a bacterial overgrowth, in general, that can create an elevation of what’s called Beta-glucuronidase, which is an enzyme that’s gonna cause you to recirculate hormones and so, you have this personal trainer beating you up and you’re not making progress. If you don’t look at this marker and you don’t fix the gut, you’re likely not gonna have many results and the personal trainer is gonna take it personal. They’re gonna try to hit you harder, they’re gonna try to kill you and I’ve heard this before when women are literally dropping out of fitness classes because the instructor’s just beating, beating, beating and it’s like that’s the definition of insanity. So, you got to get this root causes. If you’ve got this recirculation of these hormones and or toxins like mycotoxins, I don’t care how hard you hit the CrossFit, you’re not gonna get the results that you want. 

Dr. Justin Marchegiani: Absolutely. And also, just if the fats over that muscle, you’re gonna feel a little bit flabby even though the muscle underneath is getting a little bit stronger. So, you know, I always recommend getting your micronutrients dialed in, getting your carbohydrates in check so you’re not overdoing it, uh, because the more carbohydrates you make, the more insulin, the more you’re gonna be storing your fuel as fat. And again, the more your metabolism is higher, you’re more ectomorphic, you’re leaner naturally, you can handle more carbohydrates, right? The goal is that we individualize things for each person because, you know, we talk about low carb or keto, some people don’t need to do that and some people can be keto and much higher levels of carbohydrates. Some people can be ketogenic at 100 grams, for 200 grams of carbohydrates a day based on their activity and their metabolism. Some needs to be like minus 20 or 30 net. So, everyone’s a little bit different, I think that’s the important. There’s some individuality there. I would say the next thing is we, um, if you’re a female, it’s really important, menopause can really throw women’s metabolism off. If there’s low thyroid or Hashimoto’s that can really throw metabolism off. So, if you’re struggling, you’re having a hard time, we have to look at your thyroid function, look at your T3, your thyroid levels, look at antibodies, make sure that’s under control. If progesterone and estrogen is very low especially estriol and progesterone that can affect muscle building. Progesterone is really important for collagen and elasticity formation. It’s part of the reason why women get a lot of varicose veins is low progesterone, which has a major effect on the elasticity of the veins. So very important there. And then I would also say, um, toxin exposure, right? If you have lots of estrogen, if your estrogen dominant from birth control pills or estrogen from meats or milks or soy, that can put you in more of a fat storing mode because these hormones produce more fat and then guess what your fat also has an exocrine function in regards to producing estrogen. The fatter you get then the more fat you get and the more estrogen your fat cells produce. It’s just like downward spiral that just kind of, is a positive feedback loops that gets worse and worse as you go along. So, you really have to look at toxins in meat, pesticides which are all hormone-based, drugs that are gonna have estrogens in it, birth control pills, etc., milks, plastics, eating your foods out of plastic especially plastics that you’re warming things up on or you’re letting UV light hit, definitely not a good thing out of the gates.   

Evan Brand: Yeah. Well said on the thyroid too and your personal trainer is likely not testing your thyroid, so obviously, that’s were gonna be doing. And then also you know, we have a lot of experience with fitness. So, we try to educate people and give fitness plans and advice where we can there. And, I think the big people are skipping the foundational pieces. I mean, it’s fine if you just want to sign up for a class and try to get active but really, I would say, get some of these labs run first. Get your gut looked at so we can see what type of bacterial overgrowth you have, as I mentioned this is an epidemic problem. This is not a rare situation and the gut can be one of the big wrenches in your gears. That’s not allowing you to lose the weight properly and like I said, have people literally lose 75 pounds, just by fixing some of these strategies like fixing digestion. Now, for some people it could go to the other way. Some of these issues with females, it’ll cause weight loss and they’re having issues with getting muscle back, you know, building it back. And so, it depends on where you’re at. Some, they lose muscle and they still have body fat but they’re thin they’re like a skinny fat, they call it, you know, you could have a woman who’s five foot two and she’s 140lbs. And then all of a sudden, she gets sick, loses weight, now she’s 120 but she still looks flabby. That could just be because she lost that muscle due to malabsorption due to these infections like H. pylori. You and I’ve talked about the story of me where I lost 25 pounds without trying, I didn’t really have much weight to lose, but I got super skinny due to my gut infections and so it took me literally several years to build the muscle back but the first step to building back was to get rid of the gut infections and then still working on detox. I had a ton of mold toxin issues and that really screwed up my metabolism to where I was very hungry like 2 – 3 hours, I’d have to eat and no matter if it was a grass-fed steak or what. And now, I could literally go from 7am to 1pm without food and I feel like perfectly fine. I feel satiated, my brain works better, I have more mental clarity, so a lot of it’s the as you mentioned. It’s the blood sugar involvement too so you have to fix that.  

Dr. Justin Marchegiani: 110% So like the big checklist out of the gates is don’t do too much carbohydrates. Too much carbohydrate, too much sugar will make you a little bit flabby whether it’s through cortisol, whether it’s through inflammation, oxidative stress. Of course, if you’re eating a lot more carbs, right, you’re not really getting enough protein typically, right? Unless, you are someone who’s higher metabolism and really making sure proteins and carbs are dialed in and you’re doing a lot of activity. Most people, they do too much carbs too much sugar, they tend to not be getting enough protein. So, half of your body weight in grams is usually pretty decent out of the gates and then you can go up to one gram per pound of body weight depending on how active you are. So, some are gonna be good, most women are gonna be good, somewhere between a half to maybe two-thirds to three-quarters. And a lot of male people that wanna get really big, they may want to be one gram per pound of body weight. That’s kind of a good sliding scale. 

Evan Brand: Now, in the beginning, I was saying I don’t think people need to count, measure, weigh and then now you’re giving numbers so I just want to clarify kind of where I am with it. I think you can and should, to get a ballpark of where you’re at based on your meals but you should not be obsessing about it. 

Dr. Justin Marchegiani: Yeah, so I keep it really simple, right? And so, what is, um, what is about four ounces of protein is gonna be about 25 – 30 grams of protein, right?  And so, for most women, that’s gonna be about a palm to a fist size. And so, when you looking at, picking up, you know, you’re serving yourself a meal, it’s very simple, you know, there’s no weighing or measuring, you’re just kind of like what is about a palm to a fist size in regards to my hand, in regards to that serving of protein on the plate and you just scoop yourself up that amount anyway and that’s your amount. So, there’s no real crazy amount of weighing or measuring, it’s just kind of eyeballing kind of your own anatomy comparatively to what’s on the plate, and that’s usually a pretty good rule of thumb. And you know you did pretty, pretty good it’s because you’re gonna feel satiated after that meal, you’re going to eat about 10 minutes after you finished eating. The goal is we want to feel satiated enough where we can go 4 – 5 hours to the next meal. So, that’s kind of give you enough. We’re not pulling on a scale. We’re not having to measure but you got to know that like in the end, if you’re eating enough, well, what does that really mean? You ate some size amount. What is that size? It’s probably gonna be between 3 and 5 ounces of protein on average and then you can just use your hand as a good frame of reference when you’re serving yourself up. Keep it simple. 

Evan Brand: Yeah. Thanks for clarifying that because I said a lot of people, they’re just so brainwashed from conventional dieting and stuff and they get freaked out about food. They have like a PTSD of food portioning and all that and they think they have to do that. And you don’t and once you get clued in with your satiety signals. It’s so easy, you don’t need to think about it and. 

Dr. Justin Marchegiani: It’s a good frame of reference, right? Because in the end, you’ve gotta serve yourself up something. How do you know to serve yourself up this much versus this much, right? You know, usually, you know, 3 – 6 ounces, 3 – 5 ounces would be pretty good. So, like for a guy, right, I’m 6 – 10-ish, right? I have bigger hands to like I may serve protein amounts the size of my hound. So, go between a palm to a palm, to a fist to a full hand is usually that frame of reference. The more active you are, the more stressed you are, the more act, you know, the more you’re doing exercise, move to a protein amount the size of your full hand. The less active you are, you can go to that palm size. And if you just starting out like you’re coming on board like being like a vegan vegetarian where there’s not a lot of protein. Start with a quarter palm then kind of work your way up. And again, if you have problems with your protein, it typically means you have low hydrochloric acid, low enzymes and you have to really work with a good functional medicine person to get your HCl and enzymes up and you may have H. pylori and SIBO and other bacterial imbalances that are impending your digestion so you have to look deeper if those symptoms come up. It’s not the protein, it’s the fact that your digestive system is weaker and cannot tolerate the protein. 

Evan Brand: Yeah. Well said. A lot of people blame the meat, ‘oh, I feel bad when I eat meat, so I’m not gonna eat meat’. It’s like, no. That’s, you’re supposed to be doing that. Like, I have a client the other day that was in South Dakota, super strict vegan. And I’m like, ‘okey how dedicated are you to being vegan?’. Like, well, they’re totally like, ‘I’m total dedicated’. Like, okay, so if let’s just role play, I was like, ‘okay, if there were no planes, no trains, no buses, no semi-tracks and it’s the middle of February and there’s a foot of snow on the ground in South Dakota, are you gonna be able to stick to your diet?’ The answer is ‘no way’. I’m like, ‘what would you be eating that’s in the landscape?’ Animals. So, we don’t have to turn into that podcast but I just want people to know, how important these things are. They really do help stabilize blood sugar. Could you make vegetarian vegan diets work? Maybe, if you try really, really hard. But that’s a whole other podcast. Let’s go back to the mycotoxin piece for a minute because something we’re seeing is something called Zearalenone, which is highly, highly estrogenic mycotoxin and it comes from a mold Fusarium which grows in water damaged buildings. Now, you will get exposed to some of this from moldy contaminated grains but I would say that vast majority, 90% of it, I would estimate is probably from buildings meaning whether your mother had mold and passed it in utero and if you are breastfed, if you went to moldy daycare as a kid, moldy elementary, middle, high school, moldy homeschool, moldy college, moldy dorm, moldy office building. I mean this is an epidemic problem. I see it literally every single day, all day and Zearalenone really screws up your estrogen, actually far more than soy. It’s way more estrogenic than soy. So, we do talk about, you know, the pitfalls of doing like soy protein and that kind of thing. But man, Zearalenone will screw you up way more than soy protein. And this is something you have to use binders to pull it out of the system. So, if you’re struggling with weight loss, you are having these estrogen dominant symptoms. Maybe, you’ve worked on the hormone piece, but you’re still struggling. Maybe you’ve implemented something like calcium D-Glucarate to work on that glucuronidation pathway but you’re still suffering, you may need to look into this and we measure this via urine. So, this is where, like you mentioned, a good work-up comes in handy. We’re gonna do urine, we’re gonna do stool as needed. We can look into these different body systems and find the dysfunction but this is the real root cause, functional medicine strategy to have lean muscle mass and lose body fat. And unfortunately, this is a very, very not talked about discussion. You and I talked before we hit record, there’s a lot of talking heads on the internet. People that will say this study says that and this study says that but none of them are actually doing the clinical work and we wouldn’t be able to do what we do if we didn’t get results. And we get results because we’re running the right labs, we’re doing the right root cause strategy which is getting these toxins out of the system. And I’ve seen it in children as young as five, I’ve seen it in two, three, four-year-old. I’ve seen it in my own kids, we tested their urine and see mycotoxins. So, this is a problem that it does affect kids. Now, you know, obesity in children usually there is diet issues but I have seen in some cases, I have a lady in New York, her 8-year-old was basically eating paleo but she was obese and she had extremely high levels of Zearalenone. Luckily for this little girl, we were able to do binders, she was able to swallow pills which was great because it made it easier and boom this kid lost weight, she didn’t change anything with diet. She just detoxed. So, honestly with so much toxins that we’re up against, I would say detox support for life is really how I approach the conversational people. 

Dr. Justin Marchegiani: Exactly. So, if you’re in a moldy home, you know definitely get your home tested. If you have a lot of mold toxins out of the gate, you know, it depends on kind of where you’re at. If there’s an active mold stress in the environment, I typically recommend work on getting your digestion, your diet, your inflammation dialed in. If there’s no active mold in your environment and then work on dealing with mold detoxification once you have more stability with all your other organ systems and immune function. So, it just depends upon where you’re coming from. If you have like active mold in your environment, that’s the easiest way to detoxify out of the gates is to get the environment kind of more dialed in and we have a podcast on that topic that we can put in the links down below. Evan, anything else you want to highlight for the listeners? So, I mean digestion is really important, HCl, enzymes, bacterial overgrowth, poor digestion, we talked about getting enough protein and again we thought you kind of talked about measuring not measuring but just kind of using your own anatomy as frame of reference because you have to serve yourself anyway in regards to what you’re eating. So, it just gives you a good frame of reference that you know how much to give and then ideally enough so you feel full and that you’ll last about 4 to 5 hours. Now, if you’re working with trainers out of the gates, do enough where you feel sore not overly sore, the next day or two make sure you walk out of the gym feeling more energized than when you started. Make sure you can emotionally repeat what you are doing, you’re not emotionally exasperated and then also that next day or that later on that day. If it’s a morning workout, make sure you don’t feel run over by a bus, make sure you’re doing just enough where your body can adapt to. It’s all about adaptation, can you adapt to it, from it, can you feel better then afterwards. And again, if you’re doing a brand-new movement, you may feel a little bit sore and it’s a new movement so just, you know, try to keep that in the back of your head too.  

Evan Brand: And, if you can’t recover then there’s probably some level of mitochondrial dysfunction. We’re also gonna look at that, if we look at chemical profile testing, there’s a marker there. If we look at organic acids, we can look at mitochondria there. So, for me, after I got exposed to mold, I would tell you, my performance and my recovery was terrible. I mean, I used to recover in like a day or two. It was like 3 days, I was still sore, I was like, man, this is not right. Once I got the mitochondria working better, retested, look at it, I confirmed, hey, that was directly correlated. And we’ve talked about this I think briefly before but the issue of bacterial overgrowth and that producing high levels of lactic acid so you could have a high baseline level of lactic acid which creates this soreness even just from the overgrowth in your gut. So, we’ll have a woman that’ll say, ‘oh my God. I’m sore and I haven’t done anything, all I done was go in the garden, why am I so damn sore’. Their bucket was already so full due to the gut infection. So, fix that, test it, and fix it. The last thing I was gonna say was on the environment, which is that you can’t get well in a sick environment. So, whether that’s bad lighting, LED lighting, try to use incandescent bulbs, like half natural lights, like I’m surrounded by a bunch of windows. Getting that bright light exposure to help regulate your cortisol rhythm, making sure you’re using twilight or some other app at night on your phone, if you’re doing blue light at night, because we know that blue light can make you fat through various mechanisms affecting glucose and cortisol making sure your detoxing making sure you’re not wearing synthetic fragrance, I mean there’s so many people we asked this on the intake form. Do you use scented products? I will tell you, I’m very surprised how many people are seeking out natural functional medicine and they still use scented laundry detergent, dryer sheets. All these synthetic fragrances, they can affect your hormones and they’re not good. They are bad toxins. They’re endocrine disruptors. So, go free and clear. It’s not expensive, every mainstream brand has a free and clear unscented version. So, implement that easily. You don’t want to be wearing endocrine disruptors on your clothes all day, you’re already exposed to those. If you go out, even to Chipotle, which I think is one of the best places you could go if you have to eat out. Even their bowls have those non-stick chemicals in there. So, you’re getting exposed to toxins even if you’re not trying, the last thing you want to do is wear those and put your husband or your kids in those clothes. So, go fragrance free please. 

Dr. Justin Marchegiani: And also, by the way, you know, if you show up to the store like my wife got Thai the other day. I went and picked it up for and they like scooped it and put it in like, like this hot coconut, you know, curry in a plastic container. So, I recommend, if you can, you know, keep a Pyrex container in your car, so if you go out to these places, literally bring your own glass Pyrex. Hey, can you please put it in this. 

Evan Brand: They might. They might comply. Yeah. 

Dr. Justin Marchegiani: I’ve done it before. I’ve done it with Thai a lot of times because it’s so hot so I’ll just bring it but like hey can you please have the cook put it in this place. 

Evan Brand: That’s awesome. I travel with my own. We travel with our own, you know water bottles, we’ll bring our own stainless-steel cups everywhere we go. So, we’re not drinking water that’s gonna be contaminated with small amounts of pesticide and herbicide and pharmaceutical drugs. You can look up the environmental working group. For people listening, type in, EWG water report. You can put in your zip code. Here in Kentucky, where I am, we have certain chemicals in the water hundreds of times higher than the safe levels that are all highly carcinogenic and endocrine disruptors. So, this is not just, we’re being picky, no, the water in tap water is toxic. So, you need to travel with filtered water and you’re saving your gut. We know that parts per billion of glyphosate damages good bacteria which creates bacterial overgrowth. So, unfortunately it has become more complicated to become healthy. Have you seen those memes, I’m sure you have of like a bunch of skinny people at the beach in the 1960s and all the obese people in the 2020s at the beach and it’s like ‘what happened? ‘. And there was a lot less of that toxic exposure back then than now.  

Dr. Justin Marchegiani: Yeah, there was also carbohydrates too, I mean there was no trans fat back then. If you look at carbohydrates, if you look at, like, the macronutrients per decade, proteins relatively flat, you’ll see fat drop and you’ll see carb increase. So really, it’s a lot more carbs, a lot less good fat. So, of course, good healthy saturated fats, I mean up until 1988, McDonalds have beef tallow, up until the uh, I think it’s the CSPA whatever one of these vegan groups came in and wanted soybean oil which just disastrous, I mean if you had reasonably non-GMO free, um, potatoes in some beef tallow that’s amazing, that’s actually not even that bad. Um, but they changed it to soy in ’88 so you have a lot more processed vegetable oils, omega-6 that just really damaged, uh, that gets into your cell membrane and really toxifies your cell membrane, and it takes years to come out. So, make sure, you’re consuming really good high quality animal saturated fats and if you’re doing, you know, monounsaturated to keep it like avocado, keep it to high quality cold pressed olive oil and try to get at least half of your fats from high quality saturated fats. That’s important. 

Evan Brand: Yeah. The oils are, men, we can do, let’s do a whole like oil special but in general the seed oils and all that are no good. 

Dr. Justin Marchegiani: If you guys enjoyed today’s podcast, let us know. Put it in the notes. Put it in the description, please give us a share with your friends or family, also give us a like and a thumbs up that helps the search algorithm. And if you wanna reach out to Evan, head over to evanbrand.com. There’ll be a link where you can click and work with Evan. Head over to my site, justinhealth.com. I’m Dr. J, we’ll put links down below. If you’re gonna work with us, we are available worldwide. We work with a wide variety of patients from the young, from the old, females, men, etc. A lot of hormone issues, a lot of gut issues, a lot of toxicity issues that’s our specialty. We’re here to help you out and if you want to support us, we’ll put down the links below to different products that we recommend in regards to today’s podcast. Evan, anything else?

Evan Brand: Yeah. Last thing I would say, so many people have already tried everything and been to everybody and seen many, many people before they come to us, so I’m not bragging about that but it just happens to be that you and I are the people who are working with people generally somewhere close to the end of their rope and that puts a lot of pressure on us clinically to make sure that we get good results and we come through with that and you can read hundreds and hundreds and hundreds of 5 star of our clinic reviews, not just the podcast reviews but the clinic reviews too. So, I encourage people that if you’re like, ‘oh God could these guys really help, I don’t know I’ve already seen this person and that person. I’ve seen a lot of people do what was called functional and was not functional like, ‘oh I went to this integrative doctor’ and she ran one blood test for the hormones and that was it, like that’s not a functional protocol. I’m sorry. You didn’t get anywhere close to the functional workup that they’re claiming. So, functional is becoming this marketing term but there’s so many people that are not truly doing that. And I want to just encourage you and give you inspiration that we’re doing the real deal here. 

Dr. Justin Marchegiani: 100% Really appreciate it. All right guys, if you enjoy it, thumbs up comments below. We’re here to help. Have a good one you all. We will be back again. Take care. 

Evan Brand: See you. 

Dr. Justin Marchegiani: Bye-bye 

Evan Brand: Bye. 


References:

https://justinhealth.com/

https://www.evanbrand.com/

Recommended Products:

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Audio Podcast:

https://justinhealth.libsyn.com/why-you-cant-put-on-muscle-functional-medicine-solutions-to-avoid-being-flabby-podcast-357

The Neufit Method wtih Garrett Salpeter – Faster Healing and Optimal Performance | Podcast #354

In this video, we have Dr. J and Garret Salpeter, the founder of Neufit Technology. Performance and recovery go hand in hand when training or doing physical activities, regardless if you’re an athlete or not. The Neufit Method improves performance and muscle health and optimizes recovery. Further, this video will tackle optimizing performance in fitness, improving the recovery process, and breaking down the significance of The Neufit Method.

Garret Salpeter emphasizes that even if you are not an athlete, you should know how to let your body rest, heal, and recover properly from any form of injury or physical activity. Everyone has their activity levels to maintain. It may not be sports-related, but everyone demands effort from their bodies on a day-to-day basis.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

0:00 – Introduction
4;49 – What makes The Neufit Method different?
7:48 – The neurological response to injury and trauma
17:12 – The link of soft tissue of mobilization and nervous system
21:35 – The recent add-ons of Neufit Method
32:31 – Foundational diet changes to improve healing


Dr. Justin Marchegiani: Hey guys, it’s Dr. Justin Marchegiani here. I am with Garrett Salpeter, who is a CEO founder of NeuFit technologies down in Austin, Texas. Garrett is a great friend, as well as, an amazing colleague and he’s got a new book that we’re gonna chat about today. So, I’m gonna go through some of the, I think, the biggest take-home items that anyone listening can use to help accelerate their body’s ability to heal and perform better. Really excited to have Garrett on the podcast today. Garrett, how you doing man?

Garrett Salpeter: Thanks, Justin. It’s awesome to be here. Great getting to catch up with you before hopping on here and, uh, I’m excited to be on and appreciate the opportunity to talk about the book.   

Dr. Justin Marchegiani: Awesome. Very cool. Love the graphics, love the cover, um, really nice, really enticing, been kind of going through some of the aspects of the book different parts of the book. What was the process of, you know, your last ten-year journey writing this book? I mean, do you just kind of go through and think about your biggest clinical wins with patients like how do you kind of go in and get this thing moving because there’s so much that you can talk about over the last 10-12 years of seeing thousands of patients? How do you go about and just start crystallizing that?

Garrett Salpeter: It’s, you know, it’s an interesting process. It’s something that was on my mind for a while like for a couple of years before I finally decided to start and then I worked on it, you know, in early morning hour before the kids woke up and in evenings and you know, so I worked on it off and on again for a couple of years. The original catalyst for doing it was a combination of two things: one is people telling me hey you know you gotta write a book to share you know you here all these great stories about how these technology helps these create these miraculous recovery stories and then what really motivated me to finally do it is I kept getting ask by people like hey where can I read more about this, hey where’s the book in this and I my answer until recently was well it’s you know stuff that I’ve learned by combining reading textbooks and combining different mentorships and workshops and experiences that I’ve done in the field of physical therapy and functional neurology and pedagogy and physiological psychology. And so, there wasn’t a place where everything was kind of brought together in one way and so that was a big motivating factor for me was to have a resource, to be able to share with people and then, um, and then I kind of fell into this trap of making it, you know, just going like super deep on all these areas that I’m interested in. Originally, the first version of the book was probably too dense and academic and so I had written, you know, I’d got to get up in the morning for an hour before the kids wake up and write this over the course of, you know, a year and a half probably. Got to 130,000 words, which is like a, you know, a huge like a thick textbook encyclopedia type thing. And then, we finally, you know, we’re talking with our team about hey what’s gonna be the most valuable thing that we can offer to people and we decided that it would be something that was more accessible that more people, you know, clinicians and lay people alike would be able to read and so I worked with an editor to help break it down from, you know, from 130, 000 words to 60, 000 literally like cut it half and then this is the finished product.   

Dr. Justin Marchegiani: Very cool. Because I know you started off your PhD in this type of field in exercise physiology, human performance and a lot of, uh, electoral physiology technology and how it connects to healing. So, you kind of had this thesis kind of in mind and took that and kind of translate it back into a handbook that people can apply kind of day in day out for performance. So, it’s a big shift at the doctoral level, back to the everyday human level. 

Garrett Salpeter: That’s right. It’s been kind of interesting thing, you know, like that it’s very true what I describe to people when ask me for the book before this was out was, you know, I’d say it’s a kind of this breadcrumb trail that I’ve been following through the research and these different disciplines and as part of my journey in trying to piece together this knowledge base in a meaningful way that can be beneficial clinically and in all these different settings, you know, part of my journey like I was  so passionate about learning about this stuff and that I ended up going back to school into this neuroscience based PhD program in emphasis in motor control and I ended up ultimately leaving that in order to launch our product and, you know, do the other things that I’m doing now but we have a PhD neuroscientist who’s our director of research now, who’s been able to do that even better than I could or would. So, that’s great but, yeah, I mean, I literally have had to go all these different directions to piece it together and it’s just, you know, it’s very exciting to be able to come back full circle and package it together into a book like this that draws on all those different disciplines.   

Dr. Justin Marchegiani: Yeah. Very cool. Because how I first came across you before I moved down to Austin is I found a lot of your YouTube videos online. And one of the things that struck me was you had a lot of these, you know, stories, this kind of timeline, um, situations. Where someone would come in with an injury and you would kind of timeline their ability to heal over 2 or 3 months or so of major injuries that would take six months – twelve months and I was blown away with the idea that you could take people that hey this injury according to conventional orthopedics is a one year to finish to heal and you would take these people and get their injury recovery time down in half or even 60 or 70% faster. I thought that was amazing and it kind of sold itself that hey what you’re doing is working and so that was pretty cool. Can you talk about, you know, some of the tenets that you are applying that you were applying that was allowing you to do better than what the conventional PT, Orthopedic surgery route was?     

Garrett Salpeter: That’s a great question and that is, is kind of like, okay what’s the special sauce, what makes it different and that’s one of the biggest themes in the book that we talk about is making this distinction between hardware and software, between how most typical therapeutic interventions, most traditional physical therapy orthopedic medicine, is focused really enamored with and obsessed with tissue and structure whereas, there’s a whole other side of that coin, right? There’s function like hardware and software. The software, the function, which is of course is controlled neurologically is so often overlooked and ignored in these traditional models. And we’ve found that being able to prioritize the neurological response to injury and trauma is a huge catalyst for this breakthrough and a lot of it, is just as simple as, you know, look if you’re if your body naturally bracing and guarding and creating a bunch of tension around an injury, it can be impairing, blocking some of the blood flow and impairing the ability of the body to send nutrients and raw materials to heal there. So, the tissue of course that hardware component is important but the neurological response to injury is an impediment that blocks or delays that tissue healing process. By putting that first, by looking first at that neurological response to injury by finding where in the body it’s being imposed and resetting ang recalibrating that to an appropriate level, we’ve been able to open the floodgates if you will. So, the body’s natural healing process can progress without impairment and when it goes at its normal rate it’s not like we’re not doing anything we’re just allowing the body to heal and it’s just, you know, so if few people have been able to experience what the body can do when it’s really unleashed so to speak, that those faster healing times seem miraculous and really the miracle is in just removing those impediments, getting them out of the way and allowing the body to do it’s thing because it is a miracle.   

Dr. Justin Marchegiani: So, essentially, conventional medicine they’re just kind of, they’re cutting out the injured inflamed tissue, there’s not really a lot of look at how that tissue got injured from a mechanistic standpoint then they hand them off to the PT that’s just stretching, typically stretching or strengthening that area without really looking at that whole chain. So, essentially, you’re looking at everything like it’s connected to the kinetic chain. So, you’re looking at all the muscles and the joints above and below, and you’re looking at the nervous system’s ability to recruit and stabilize those different areas. So, you have your Neubie device, so you’re using that as a means of one I think rehabbing and strengthening the muscle and the nervous, but you’re also using it as a means of detection. Can you talk about how it has dual purposes? 

Garrett Salpeter: Yeah, absolutely. So, when we talked about this neurological response to injury and trauma, there’s the concept and then there’s actually the process of finding where in the body it exist and what it’s doing in the body and to understand what it is, one of my favorite metaphors is actually to talk about this notion of imagine a snake was, you know, come in, so I’m in my home office here imagine a venomous snake was coming into my office for me to react like this and you kind of run away or mobilize some energy so I can protect myself, that’s useful, that’s a valuable, you know, it’s a fear-based flight-or-flight response that mobilizes me to take action so I can you know fight or defend or protect myself or run away and flee and that’s valuable. However, if I react the same way to a rubber snake that my rubber snake that my daughter put there, that’s an over reaction that’s inappropriate. I’m wasting this energy, um, you know, trying to protect myself from something that’s not a real threat and our brains and nervous systems do this to us and you know forgetting these examples of like pain and injury for example. A lot of people have these experience, you know, thinking about someone who gets really nervous before they go public speaking for example, something like that. That’s the brain’s way of saying, hey this is life threatening we gotta protect you from this risk of being embarrassed because if you go out there and make a fool of yourself, you could get kicked out of the tribe for example, there’s like a deep survival fears associated with that. I think we all recognize that, you know, that fear is a kind of a hypersensitivity or it’s an overreaction or it’s a little bit mis calibrated to the situation like we recognize intellectually that we’re not really gonna die, if we go out on stage, because it feels like that because we’re overreacting. And the similar type of thing happens where, if we have an injury, you know, it’s football season, we’re working with a lot of professional and college and high school football players, you know, if an athlete goes out and sprains his ankle and they are totally shutting down as a response to that injury and that trauma, if they’re you know creating tension to lock down some muscles and totally shutting down others, that can be potentially productive if like if they were gonna roll that ankle again, it could that bracing could be protected there but if they’re not doing that if they’re trying to rehab and get to normal movements those patterns actually stand in the way, they delay that recovery process, they’re reacting, you know, as if they’re as if they’re pounding that ankle again, like there’s a real snake coming in when really it’s a rubber snake and they’re safe now, they just have to get themselves in the right state where they can heal. And by shifting by first of all identifying where so, to actually answer your question, if we’re able to take the Neubie device and scan around in their body, we can find where those hypersensitivity are in the nervous system where the brain and nervous system are shutting down muscles or creating these bracing and guarding patterns where they’re holding on in other muscles. We can find where those are and then send this very unique direct current stimulation to rest and recalibrate the nervous system and what does that really mean, well, it means, you know, an athlete who comes in with a sprained ankle who’s on crutches or can’t put any weight on their leg often times after that first session can walk normally it can load that weight, the load weight on their leg without pain and they make these amazing transformations in 15 minutes and you think, gosh, what happened to that 15 minutes. Did the ligament that was partially torn, you know, if it was a grade 2 and it’s a partial tear of the ligament, did that ligament heal in 15 minutes? No of course not. What happened was you reset and recalibrated those that suite of neurological protective patterns which some of which are tension, some of which are inhibition or turning off muscles and part of that is also pain. Pai is a protective output of the brain that’s part of that whole host of protective patterns and by resetting that, you immediately restore function back to a normal healthy level. They’re not ready to go back on the football field after that session, however, they’re in a state where they can move better, their muscles can better support that injured tissue as it heals and you’ve opened those floodgates, so healing mechanisms can actually work at their normal rate and do what their capable of doing.  

Dr. Justin Marchegiani: What was always fascinating for me is when you would use the Neubie device to kind of search and scan the different tissue. Let’s say, you had direct pain on the knee, when you would search, you know, let’s say, from the hip down the quad right biceps femoris to rectus femoris into the calf, you would find hot spots or pain areas that would that the Neubie would pick up that you would perceive as pain but they wouldn’t necessarily be in the areas of pain. I think this is kind of what you’re taking about is conventional medicine would say oh I feel pain on the knee they’re focus on the knee. But you would scan it and you would get this feedback, that the patient would feel and they would feel areas of pain totally away from where that is. How does that happen, how does that work?

Garrett Salpeter: So, that speaks to a couple of these really powerful concepts like the difference between structure and function and also this notion that you talked about a lot about getting the root cause of the problem, right, you know, if you’re walking around all day and part of your quad muscles doesn’t work, you’re just kind of collapsing into that knee joint all day long and you’re gonna be setting yourself up for injury and you know eventually the knee starts hurting and you go and treat the knee but you’re not if you don’t go upstream and address that dysfunction or why it happened in the first place, you’re never gonna have a true long term resolution of the problem. And so, what the mapping allows us to do is to find where the dysfunctions are, which..

Dr. Justin Marchegiani: How do you measure that, like what’s the Neubie putting through like is there resistance in the tissue due to inflammation, lack of blood flow, like what’s causing that feedback at the tissue from a biochemical physiological level? 

Garrett Salpeter: Ah, yes.  So, the reaction, one of the things we’re working on is being able to measure some of these quantitatively and that so we should have some really cool information on that, you know, in the next couple of years as we build out our research program. What we know now, and what we’re identifying are areas where these exact neurologic protective mechanisms are present. So, what we’re doing as we’re scanning around, so if I have an electron pad, like this, and I’m scanning around the body what’s really cool about this current, so traditional first, we need a little context here so this makes sense, traditional electrical stimulation device is alternating current, tens units, Russian stim, they, when you turn them up to a high enough level to really make a difference, they cause muscles to contract and that becomes the limiting factor whereas with Neubie, we can at least to some degree, we can bypass a lot of that protective muscle contraction and speak more directly and powerfully to the nervous system. So, again, a little bit difference between structure and function, thinking directly about the nervous system. When we scan over the body, we’re sending a signal to the nervous system in the brain saying hey this area is being used, this area is being loaded, then we go here, hey this area is being used, this area is being loaded, here, hey, this area is being used being loaded. And wherever the body is working well, the brain sees that and says, you know, if were scanning it says oh that’s just Dr. Justin’s deltoid doing its normal thing, that’s just Dr. Justin’s biceps doing its normal thing. There’s nothing alarming about that, but if we stimulate a muscle or an area that either hasn’t been working recently because that habits or an area where one of these hypersensitivity and these, you know, these protective patterns that are being imposed on the body, if we scan one of those, the brain sees that and says whoa whoa whoa that’s threatening that’s alarming and it fights it, it reacts kind of a trigger point. If you were working on somebody and that you find that trigger point area that’s more sensitive. So, we find these areas of hypersensitivity and then we want to stimulate them and teach the, ultimately the brain, teach the brain and the nervous system that it can calm down that hypersensitivity. So, it’s, instead of you know, it’s like if you’re driving your car either you hit your throttle down harder or you can just take your other foot off the brake. Here, we’re trying to train you, you know, train your body to take the foot off the brake where it hand been imposing these limiting patterns.  

Dr. Justin Marchegiani: Very cool. So, I know with the Neubie, unlike with your typical tens unit, right, you’re typically not gonna be exercising with like a tens unit, it’s like more like an electric aspirin. It’s kind of blocking the pain going into the brain. Here you’re actually able to move it in rehab. I’m just curious, a lot of different techniques in soft tissue world like Graston and active release technique, part of the reason on how they promote healing is they work on improving blood flow and they help release the fascia from the muscle belly. My experience using it, when I exercise with the pads on the various areas that in the current, I feel like there may be fascial release on that muscle helping to improve pain. Just curious, what’s your take on that fascia and the muscle kind of being mobilize and moving better?

Garrett Salpeter: This is really an interesting topic and there’s a few thoughts I have on that. One is people are doing manual therapy, it’s kind of this interesting..

Dr. Justin Marchegiani: I’m sorry just to add one little context. If this is my muscle belly, the fascia is like my shirt on top of it, so when tissue gets inflamed it’s like wearing a wet t-shirt it’s hard to get it off and so, just kind of giving people a visual imagine the we t-shirt on someone’s body that t-shirt is stuck and so helping to mobilize that t-shirt so to speak can help promote healing, go ahead. 

Garrett Salpeter: So, there’s really, really important interesting connection between the movement of tissues and the function of the nervous system, so like in your example if that fascia or that shirt is glued down on the tissue underneath it, you miss out on that gliding and sliding between layers and you don’t get the neurological input from that area, so it goes out, you lose out on that, so the nervous system is this big feedback loop and all of the outputs of the nervous system which of course includes movement and pain. It also includes hormones, it includes heart rate and blood pressure, digestion like the nervous system controls our visceral organ function. So, all of these outputs of the nervous system that are relevant for health and cognitive performance and athletic performance and overall well-being. All of these outputs of the nervous system are vitally dependent on the inputs given to the nervous system and that can that of course is the things that you talk about in functional medicine, nutrition and diet and these lifestyle factors. It all absolutely to do with movement, also these neurological inputs of, including the tissues gliding and sliding over each other are super relevant for the overall health of the nervous system which is super important for the health of the overall body. So, being able to, there’s a few things that happen, being able to get movement in into those tissues is very important. A lot of manual therapists, when they say, you know, I’m releasing adhesions or I’m feeling this tissue move or something like that. A lot of what we’re learning is that, what they’re really doing is not making as much of those structural changes as they think, but they’re actually giving neurological inputs, the mechanoreceptors, the nerve receptors. They’re actually activating those to create more functional changes than structural changes and ultimately though, you need both, like you need the tissues to move over each other and you need to move them through enough ranges of motion to create the inputs so the brain gets enough inputs so they can maintain healthy function and get all the inputs it needs to drive appropriate controls of the body for movement and everything else. And when we’re working with the Neubie, you’re affecting both, you’re moving and affecting structures, you’re getting mechanical tension which can, uh, which can definitely move, you know, create the kind of friction that helps break up issues between the layers of those tissues and you’re getting the neurological input. So, it can work well in combinations with those other, you know, manual therapies and ultimately you need both. I mean, you need good structure, you need good function and, uh, I hope that adequately addresses the question but I think ultimately, we’re trying to work on both.    

Dr. Justin Marchegiani: So, we’ll put some links below for people that want to get more information either about seeing Garrett or Garrett’s clinicians at his clinic or if you’re a practitioner and you want to get more information on, um, being able to use this device at your clinic or if you’re someone abroad that wants to work with Garrett’s stuff virtually, we’ll put some information down below. So, someone comes in, right, you give them a work up, you have a full physical exam, you’re looking at neurological signs, you’re testing muscles as well, to help find which muscles are off and on for compensation pattern stuff. You’re using the Neubie, you’re scanning looking for all these areas of dysfunction, you’re always evolving your method, right, the NeuFit method. What else has been plugged into the NeuFit method, the last year or two that you kind of added on recently? 

Garrett Salpeter: So, the biggest thing that we’ve done in the last year is really explored the benefits of using very specific frequencies and this is one of the biggest champions of this type of work is a doctor named Carolyn McMakin, who has seminars on frequency specific microcurrent and the basic premise is that if you, uh, basic premise is resonance so for example, if I have the keys to my car and I go out in the parking lot, I hit the unlock button, this key only unlocks my car, it doesn’t unlock your car or my friend’s car or the other car across the parking lot. It only unlocks my car because that signal resonates with that car. It’s also the same thing if you ever heard of like the opera singer who hits that note, oh, you know, much better than I would dip, and that particular frequency of that note resonates with the lead atoms in glass and it breaks the glass. So, we can apply certain frequencies in the body that will resonate or preferentially go to and interact with certain tissues. So, if you’re trying to recover from an Achilles tendon injury, for example, we can, in addition to our usual treatments working on neuromuscular function, we can use a particular frequency that would direct that signal to the tendon tissue and help even further speed up the healing and amplify the healing effect of that, increase more blood and more resources specifically to that tissue.  

Dr. Justin Marchegiani: Is this a new feature on the Neubie, where you can adjust the frequency? 

Garrett Salpeter: So, it’s something that, um, we’ve had, we built it in to the Neubie, because I had kind of glimpses of this and we’ve only started to explore the, you know, the full benefits or more of the benefits of that in the last year and it’s part of, you know, clinicians who are in our, have completed our certification. It’s actually, that’s part of the level two stratification that we put out, um, in the, sometime in the last year and that’s been really exciting to see some of the, some the, you know, outcomes that people have been able to create with that and, you know, that can go down, that goes down a whole road of, you know, like Dr. McMakin, for example, has frequencies for different organs and things like that. We with the Neubie, our work and our scope is more around, you know, neuromuscular conditions and pain and things like that, so you know, we’re not necessarily able to, you know, speak about or make direct claims related to the health of certain organs or things like that, um, but, you know, there are some really cool things that people are able to do with this concept.  

Dr. Justin Marchegiani: Very cool. There are two more things I want to hit on the book. You talked about heart rate variability which is essentially the unevenness between the heart beat and it’s a good window into recovery and the parasympathetic nervous system response. How are you gauging the amount of workload that the people you worked with can handle? Are you using HRV? How do you know, you’re doing too much? How do you know you’re on the sweet spot? How do you apply that with your patients?

Garrett Salpeter: That is, that’s a great question and this is I think part of the future of medicine and sports performance training is this notion of stress management and what heart rate variability, what it basically shows us is, it answers the question of how well are you, this individual standing in front of you, how well are you able to keep up with all the stressors in you life right now, you know, if you are, if you’re not, if you’re just like holding on to keep up with everything, you don’t have as much bandwidth to adapt to these subtle changes in air pressure as you don’t have these minor fluctuations in your heart rate, whereas if you are able to keep to keep up with that then you have more bandwidth to adapt to these subtle changes and so, heart rate variability is a great measurement. So, we look at a couple of different things that’s a big one, you know, if we look at someone’s HRV status when they come in for a session, and we see like dang they’re really in a stressed-out state. We may have a more recovery-oriented session with them that day. Over time, we also, you know, for people who have these wearable devices that tract their sleep, check their HRV, we have them do that, we just completed a study with Biostrap, who makes this one that I’m wearing in my wrist. It’s the best clinically validated of these, you know relatively inexpensive wearables, uh, they’re within one percent measurement of the gold standard, uh, of electrocardiograms like when you put electrodes all over the body and 

Dr. Justin Marchegiani: that’s called Biostrap 

Garrett Salpeter: Yeah, uh, so they have, you know, we worked with them and we saw that doing sessions on the Neubie, that people increased their heart rate variability, they decrease their resting heart rate without doing any cardiovascular training at all, um, also improved sleep and arterial elasticities, blood flow and blood vessel health and so, you know, all of that factors into, to saying looking at heart rate variability is something that we like, we don’t always look at it within a session, sometimes it’s you know, there’s a little bit of a delay in feedback. It’s well, you do something that day, see how their numbers were that night and the next day and then dial it back in the next time they come in. So, sometimes you get real-time feedback, sometimes it’s, you know, a day or two and you have to, you have to kind of start slow, see how much they can handle walk up to that line and you also have to factor in the stresses, you know in there because someone one day, if they’ve slept well and eat well might be and it’s, you know, weekend or something, might be able to handle a lot more than if they come in, in the middle of a week  when they have a deadline, if they just have, uh, a fight with their spouse or fight with their boss at work or something like that and they didn’t slept well the night before and they’re sick and they’re going to be able to handle way different amount of stress and input in those days too.  

Dr. Justin Marchegiani: Yeah. Which is totally different training philosophy, you know, 10, 20, 30 years ago was kind of like no pain no gain, you have to build a character, this is to toughen you up and it’s like well, really the goal of training is to add a stress into the neuromuscular system so your body can adapt from it and get stronger not so it can get weaker because if you can adapt to that stress, you just breaking your body down versus building it up and training and so it’s really kind of being training smarter versus harder kind of mindset. 

Garrett Salpeter: Amen. Yeah. You know, I just think about it as, if I’m gonna invest the time and effort and possibly money to go to a physical therapy session or to a training session, you know, I just wanna have a return, I wanna have some benefit to show for that. So, it’s about, you know, ultimately about finding, you know, it’s not minimal or maximal, it’s optimal, it’s that kind of bell curve, it’s finding the right amount of input to get the correct output. 

Dr. Justin Marchegiani: Love it.  Very cool. You also started working with Terry Wallis, who is a popular figure in the functional medicine community, especially, on the autoimmune side. Dr. Wallis’ kind of story is for the listeners, she had multiple sclerosis was that one point even in wheelchair bound and couldn’t, you know, couldn’t walk and then was able to make different changes in her diet to help reverse her MS and MS is an autoimmune condition that affects the myelin which is the coating around the nerve so she was able to change her nervous system or her change her immune system, uh, attacking on her nerves so then she could actually start to heal and recover and now she’s fully walking. So, you’re using the Neubie device as a means to help stimulate growth, healing. Can you talk more about that application is? 

Garrett Salpeter: Yeah. So, Dr. Wallis, I’m glad you mentioned some of her story, because it’s super inspiring and she’s now been able to help through her Wallis protocol and her book and her research, been able to help hundreds of thousands of people, stop the progression of or even reverse their MS and it has to do with a functional medicine approach reducing the inciting or damaging influences that are causing the immune system to haywire and create this autoimmune environment. All this stuff that, you know, you know more about than I do and that you talk about your podcast and the reason we worked with her is that she had this limitation in her program where she could get, she could help people stop the progression of their MS and then they get to the point where they say, okay that’s awesome. Now, what can I do to restore the function that I lost, now what can I do, if I wanna be able to drive my car again or you know, not to have caregiver at home or I wanna regain autonomy, I want to be able to walk or play the piano again, like okay, like that’s awesome.  We stopped further damage but now, how can we do that and that’s where we got connected by a mutual friend and she saw, you know, I was describing NeuFit to her and some of the work we’ve done with some other neurological patients and she saw, hey, this kind of fills in, you know, this next step in our program, and since then she’s you know, invited me to speak at several of her, uh, seminars and live and virtual events and she very graciously gave an endorsement for my book and we’ve been able to work with her to share this message and kind of plug in NeuFit as part of her program and so through her, we’ve been able to introduce this to hundreds of thousands of people and many thousands of people have, you know, some have worked with us or gotten their own machine and worked remotely and many more have found NeuFit practitioners, we have on our website, we have a directory that we can link to, a directory of certified practitioners around the world who offer NeuFit and so many of these patients have gone and found people in their community, you know, sometimes they can find someone across town or, uh, nearby that they can go see and do this work, and we’ve seen people, you know, sometimes restore a little bit of sensation and function. Sometimes get out of a wheelchair and walk again and we’ve seen some of these transformational, really inspiring and amazing stories. 

Dr. Justin Marchegiani: So, when you work with patients like that, are you doing a scanning method throughout that muscle belly area or are you just generally hitting the major muscles that aren’t working appropriately? 

Garrett Salpeter: So, we typically will do a scan so that we can direct that stimulation, you know, in basically the areas where we’re going to get the most bang for the buck and we typically would do a scan, sometimes you can guess where you’re gonna put the pads and you can guess correctly based on knowing where their impairments are but sometimes there’s some nuances or different segments or different areas that pop up so we do like to do a scan , you know, at least in he first session as part of an assessment and then there we get the information to build a custom program and figure out, okay, where we need to stimulate to help get sensation or function back in the hands and feet or start to build enough strength so they can work towards standing and then walking or start to rebuild, uh, dexterity to be able to do the activity is that they wanna do. 

Dr. Justin Marchegiani: Very cool. And then last question I have for you out of the gates here would be, nutrition is obviously important, right? It’s the building blocks of all of out nerves, our muscles, right? Quality is important, we don’t wanna add more toxins via, you know, plastics and hormones and pesticides, those kinds of things. What are some of the foundational diet changes, that you work on with your patients to really accelerate improvement? Is it the quality of the protein? Is it a certain amount, is it fats? What are the best bangs for your buck with nutrition to get better, your healing?

Garrett Salpeter: So, we’re looking at everything through a neurological lens and when we do that, we end up drawing many similar conclusions as you do through a functional medicine lens so there’s a ton of overlap. Maybe the way we speak about it or maybe the, you know, something some of the things we prioritize or emphasize are a little bit different but for us, one of the biggest in, especially in these autoimmune conditions right when you talk about the immune system and inflammation gone haywire but also just for brain and nervous system health overall. Inflammation is such a key, because if you eat an inflammatory meal, you’ll see IQ drop 10 or 20 points because the inflammation impairs brain function so significantly, and impairs peripheral nervous system function. [inaudible]

Dr. Justin Marchegiani: Blood flow too. 

Garrett Salpeter: Yeah, absolutely. So, for us reducing inflammation is one of the highest priorities be whether you’re adding in overall health or you’re looking specifically through that lens of trying to optimize neurological function. So, that becomes a big deal, reducing inflammation. So, we’re looking at you know reduce, cutting out as many Omega-6 seed oils as possible but getting more saturated fats from good heathier sources. I mean, we’ve talking about, you know, grass-fed beefs or pasture-raised other animals or wild-caught fish, different things like that, you know the sources of fat become really important in reducing the Omega-6, having good monounsaturated fats like avocado and olive oil, you know, assuming someone is screened for food sensitivities and none of these things are gonna be like an individual’s person’s kryptonite or something like eggs can be great for some people, have a good health profile, if they have those nice, good dark orange yolks, um, but for some people have sensitivities and shouldn’t have them.     

Dr. Justin Marchegiani: So, essentially, you’re really pulling out the inflammatory stuff, the refined sugar, the grains, those kin of things, maximizing good fats, maximizing good proteins, obviously having enough building blocks so the tissue we’re breaking down. There’s enough reserve to build that tissue back up as well. 

Garrett Salpeter: That’s right. Yeah. So, you know, all those sources of fat I mentioned, the meats and eggs, you know also happen to have good, very good sources of protein associated with them, I also like collagen protein, if we’re trying to help someone rebuild tissues, um, and then also when we talked about inflammation and health of the nervous system, the gut is so important. So, you know, I’m a big fan of, uh, you know, different fiber powders that I put in my drinks every morning, um, and then, uh, you know the nervous system also is a big, big, big input. So, trying to do what we can to get that parasympathetic activation, you know, as many times as we can throughout the day to help with digestion is also a huge deal. 

Dr. Justin Marchegiani: Are you still doing the ample drink every day? 

Garrett Salpeter: I haven’t done those in a while. I like those, uh, I haven’t done them. Let’s see, nut there was a reason I stopped. Oh yeah, I think I didn’t, I didn’t, I really like the concept, I just didn’t love as much of the like whey and egg white proteins. I’m more of a collagen and you know meat guy.

Dr. Justin Marchegiani: Yeah. I’m a big collagen guy too. You just don’t get enough connective tissue, amino acids, the hydroxyl proline, proline, glycine, interesting. I have the same situation. What’s one clinical pro you’ve come across recently that you think most of the audience will be able to benefit from like, just anything in the last couple of months that’s like a real heavy hitter that would help a lot of people? 

Garrett Salpeter: That’s a good, that’s a good question. Um, I mean in our realm, when we’re doing a lot more of this, you know, pain, movement, dysfunction, injury, helping people, uh, you know, the frequencies that I already mentioned, the biggest thing that jumps to my mind the last few months is some of this, some of this work that we’ve done on frequencies and, um, being able to find these resonant frequencies that it’s really cool when you feel this kind of resonating effect, it feel like this, you almost get these charges building up so it’s something that admittedly someone would  have to you know, find a provider who has our device in order to experience it but for our practitioners being able to identify this and initially this frequencies were only used really in the micro current realm but use them with stronger power delivery with stronger current levels and deliver that power, that’s been one of the biggest things that really jumps out and, um, I just I have seen, already seen some really cool things happen there so that’s one of the biggest, uh, more for practitioners who do have access to this device admittedly but, uh, it’s really, it’s a really cool effect when you see, when you feel that resonance happened. 

Dr. Justin Marchegiani: Very cool. Awesome. Well, thanks for all the excellent information, Garrett. Again, the NeuFit method, all kinds of good info and more we talked about the couple of things in the book here as well, um, take a look at it. If you have chronic pain issues, and you’re not healing or you have lingering injuries that aren’t getting over the top, we’ll put a link down below, where you can reach out to Garrett and his staff and we’ll put a link to the book as well. Appreciate it. Anywhere else Garrett, the listeners can go and check your information on it? 

Garrett Salpeter: So, we’re most active social media wise on Instagram and the handle is NeuFit RFP and its N-e-u like neurological F-i-t and then RFP for rehab fitness performance. So, I’m on there, our team’s on there, we respond to DMs and comments and everything about, uh, we’d love to interact with you there, and hopefully if you’re, you know, if you’re interested with the book, hopefully, you’ll, uh, read it, if you check it out on amazon, please do leave an honest review on there. That feedback is wonderful. It helps us know what people like, what people don’t like. What content we can provide more of and I can assure you that having put in the hours on the book, I really appreciate that feedback very well much. 

Dr. Justin Marchegiani: Very cool. If you guys are listening and driving, we’ll put links down below where you guys can reach out and support the book. Okay, Garrett, awesome chatting with you. Have a great day man. Good chat. Take Care. 

Garrett Salpeter: Thank you, Justin. It’s been a pleasure. 

Dr. Justin Marchegiani: Same here. Bye now.     


References:

https://justinhealth.com/

https://neu.fit

Audio Podcast:

https://justinhealth.libsyn.com/the-neufit-method-with-garrett-salpeter-faster-healing-and-optimal-performance-podcast-354

Recommended Product:

Neubie

 

The Top 5 Ways Your Water Could Be Hurting You & How to Fix It | Podcast #350

We need to stay hydrated but is the tap water in your home safe? When we drink water at your house, it must meet strict safety standards as well.

Water can be contaminated in several ways, according to Dr. J and Israel. It can contain bacteria and parasites that get in the water from human or animal fecal matter. It can contain chemicals from industrial waste, spraying crops, and many more. That’s why it is essential to invest in water filters if you can or make sure that your water source is safe to avoid health problems in the long run.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

1:19 – Fluoride
6:06 – Chlorine
10:45 – How does Clearly Filtered work?
18:47 – Herbicides/Pesticides
19:56 – Pharmaceutical Drugs
26:03 – Contaminants Detected
30:53 – Benefits and advantages of Clearly Filtered


Dr. Justin Marchegiani: Hey guys, it’s doctor Justin Marchegiani here. I have Israel Passwater on the show today. We are gonna be talking about water, water filtration, some of the top five toxins that may be in your water and hurting your health. So, really excited to have Israel on today’s podcast. Israel, how we doing today man? 

Israel Passwater:  Doing good man. Thanks for having me, Justin. It’s a great day, great to be here. 

Dr. Justin Marchegiani: Absolutely, really excited to have you on. Um, one of the reasons why I have Israel on, he’s an expert in water and water filtration and the different technology but Israel also has a product to it’s basically, the better Brita filter right. We all know the Brita filters, right. The problem with them, they make the water taste a little bit better but they don’t filter out a lot of the other toxins. In Israel, it’s a product that actually filters out more of the toxins and It’s a kind of a low-cost product to kind of get into the water filtration space and I’m really excited. I talk about whole house water filtration, a lot of counter top, um, reverse osmosis systems. Those are great, they also involve a little bit of install, you may not be at a property that allows you to do it. So, this technology allows you to do it passively. It’s like a Brita filter for your fridge but gets of more of the toxins and more of the crap out of the water. We’re gonna go into the technology and some of the things that we need to be avoiding in our water to have healthier metabolism. So first off like, what is the number one thing in water today that needs to be filter out that could be hurting our health? 

Israel Passwater: That’s a great question. It depends on who you ask, um, from our perspective fluoride would probably be the number one, because it’s in about 75% of the water supply, uh, internationally and nationally. So, that’s one that we believe to be in science has shown that there are, uh, issues or questions at least on the long term effects of that, uh, so typically when people are looking for, uh, like a water filter that will come about us, they say I’m looking for best water pitcher that filters fluoride or heavy metals or whatever it is you’re, you, you look on the news and you say, oh there was a contamination outbreak and there’s lead in the pipes and it’s in the water supply that’s where you know good parents like us will go and say, okay well, I need to find a solution to that. And that’s usually where people will find us without, oh wow clearly filtered. I think I’ve heard about them. If they haven’t heard of us, oh that’s pretty cool. So that’s usually the start of the journey is realizing that there is, uh, there’s toxins in the water and it’s not ah, oh maybe, oh gosh, I wonder if it’s really a real thing. It’s proven scientific. Um, so that’s usually where people kind of stumble upon us and not to start off with a scare tactic but again, that’s kind of what we do. We provide a layer of safety to bring help, people live healthier lives, you know, so we’re just. 

Dr. Justin Marchegiani: So, awesome, yeah. So, we have fluoride. Right now, there’s a lot of misconceptions on fluoride. A lot of people think of fluoride, they think of like, um, calcium fluoride, there’s some natural fluoride in the environment. You know, what we’re talking about is more of the Hydrofluorosilicic acid, more of the synthetic fluorides that, um, you know, a lot of dentists that are well-intentioned topically, may put on someone’s teeth to help make the enamel stronger, the problem is when you’re swallowing it, it’s a little bit different. It’s like seeing the benefits of sunscreen, so you don’t get burned and saying well let’s put in in the water and drink it right, so there maybe, you know, a lot of the data out there, maybe some of the benefits of fluoride, maybe more topical, but we’re talking about ingesting it orally. So probably not the best right? It’s good if you’re gonna, if you’re gonna be on a medication which fluoride is that you actually dose it. You don’t really control the dose when you put it in the water supply. So, I think that’s a good point and uh, keeping that out is beneficial and there’s a lot of studies if you go on pubmed and fluoride in the water supply and fluoride correlations affecting thyroid function and going down and even IQ going down. So, a lot of things there to kind of highlight from an implication standpoint. 

Israel Passwater: I hate going to the dentist. But last time you go to the dentist, they do the fluoride treatment, what they tell you to do, they don’t tell you to swallow it right, they say no, rinse your mouth out, right? It’s like, it’s like they go, okay well, that makes sense but then people realize that you had fluoride and stuff like chloride being in the water. It may serve a purpose but maybe not the purpose they intended it to do so. I think maybe good intentions or at the time in 1920s or 30s when they started fluorinating the water. It was because not everyone had great dental care and access to dental, dental health, you know, so again, the rationale for doing was much different, well, and then it also depends on who you ask but again that was one of the main historical pinpoints why they started doing that but as we know, doctors also used to recommend smoking for lung capacities too in the 1920s and 30s. 

Dr. Justin Marchegiani: And even sugar consumption as well, and anyone that has a kid that has like, you know, typical Colgate toothpaste, go look on the back of it, right it says you know, pinky size, pinky size amount and then it says, if you swallow, call poison control. So you know, there’s some understanding that this stuff is harmful and it’s always better to use a healthier toothpaste as well and get the fluoride out of your water, I think that’s a good first step. Also, I think half of all cavities, I think in teenagers and caused by dental fluorosis, meaning too much fluoride actually, causing the enamel almost crack. 

Israel Passwater: Yeah. It’s an over-fluoridation that the concentration. So, yeah, there’s again, it depends on who you ask, but most people that have spent anytime and obviously you have looking and researching and I would encourage everyone and again, I’m a big believer because again, I come an educator’s background, um, again, I want everyone to do their own research, always like trust but verify, um, but the internet is a powerful place and there’s a lot of things, and Justin and I were talking right before we went live and I think the cool part about, you know, living in the society that we have and sometimes scary part is the access to technology that you have at your fingertips on your iphone, uh, stuff you can research, you know, if you have trouble sleeping at night. It’s like there’s a lot of information out there, so again, I like to encourage people, whatever you know, if it’s you know, our brand or another brand, whatever, just do the research, find out what your, what’s on your water supply and you know, be aware you know and obviously drive cautiously in that sense, you know. 

Dr. Justin Marchegiani: Yeah. People are listening, if they’re really interested, I put a link down below for the clearly filtered water filter, justinhealth.com/clearly-filtered. It’ll be right below, so if you guys want to take a look at it, we’re going to just go into what those big toxins are and the technology in a few minutes. So, we hit fluoride, why don’t we go to chloride next, right, I mean chlorine has well-intentioned right? It has reasons there to kill bacteria and kill things like that, but the problem is they leave it in right and it kind of has a smell that everyone knows what that chlorine smell looks like or smells like, because of being in pools and stuff. Uh, let’s go over chlorine. 

Israel Passwater: Yeah. I mean it just depends, like again, the rationale for keeping chlorine in the water was that for transportation, you know, the idea was that they’re transporting in pipes long over long distances, you know that was the intent initially. But again, they’ve seen that chlorine vapor can cause long term damage to vital organs and they’ve there’s all sorts, there’s no reason they should be, uh, in the water supply. So, from our perspective, again, that’s another villain that people obviously don’t think about you know. They don’t think about it, oh it’s chlorinated. We’ll, that chlorine smell is, you know, what do you do when you get out of the pool, you rinse off right? It’s like you go to your face. Hopefully it’s salt water, you could. If you’re fortunate enough to have a saltwater pool but you know, what you go, you’re going to rinse off, you don’t want your hair to turn all nasty and green if you have blond hair.  So again, there’s all different reasons that you say, okay well yeah, that’s chlorinated but should I be consuming that. You don’t drink pool water, but again there’s lesser concentrations obviously in the tap water but it does exist. So again, another reason people find us say, okay well, I want to take the chlorine out of my water, oh okay cool, so.  

Dr. Justin Marchegiani: And a lot of times with that motivation, it’s more of just the taste and the smell, they just want the water to taste and smell a lot better right. So, there’s more of an anesthetic to that right?

Israel Passwater: Great point. So, a lot of it, like, if you go on our website, okay, this is I don’t want to make this salesly at all but I think if you look up different types of, uh, the contaminants we remove, a lot of the ones that are cancer caused into parts per billion not parts per million, so parts per billion. Like you take a medicine dropper, drop it in an Olympic sized swimming pool, since we’re talking about swimming pools but stay with the analogy that you take a mess and drop or drop, one drop some of these things are poisonous and parts per billion and that’s considered toxic and you think there’s a lot and the concentration is a lot higher than a lot of these. So, again, people don’t realize this and once they start to realize, they go, oh my gosh that’s really my water and there’s lots of different ways you can check your local water supply and see what’s in there and it’s truly eye-opening and if not scary. 

Dr. Justin Marchegiani: Oh yeah.  And being a functional medicine doctor, I’m very concerned about gut health and I know chlorine has a lot of negative impacts on the microbiota in the gut too. 

Israel Passwater: Yeah. Oh, I forgot one of the things I was gonna say, a lot of the things you were talking about like odor so like chlorine. Like chlorine taste and odor is pretty standard like when you look at the industry for like water filtration kind of like benchmark. It doesn’t really much, but it’s like oh it tastes good, okay great, it must not be toxic. The problem is, most of the things that are cancer causing and you know, all sorts of detrimental things, you know like are, you can’t smell it, they’re odorless, they’re tasteless and you can’t see them because they’re microscopic. So that’s kind of going around with the sun, this illusion of safety, um, but again a lot of times you can’t see something that’s going to potentially be very harmful for you and your family. And that’s, I mean it’s scary but it’s true though so when people say, oh it tastes fine okay well or like, you know, I think my water taste fine because I live next to an aquifer or something like it. Again, the assumption is it’s safe but reality is that you know, most of the population has again with fluoride that 75 plus percent of the water supply is fluorinated, so. 

Dr. Justin Marchegiani: Yeah. And then can’t chlorine convert to chloramine as well? Can you talk about that one?

Israel Passwater: Yeah. Uh, I’m trying to remember the process but yeah, they, It can, It can interact and one, the interaction sometimes can have detrimental effects as well. I’m blanking on the term, if you can prompt me that’s fine, but the point is these things shouldn’t be in the water supply anyway so, um, so yeah but yeah, so typically that’s how people find out about us or start thinking about us and that’s where we come in is like, a really good option, you know, so it’s like yeah you know, like I’m looking at your success pyramid, you know, like a lot lies underneath the surface and the same thing with water filtration. 

Dr. Justin Marchegiani: Yeah. It makes sense because they’re putting a lot of these compounds there because they’re trying to prevent, you know, the bacteria getting in the water along the way but in the end you’re gonna drink it and so it makes sense that there is some kind of end stage filtration that we put that water through before it goes in our mouth and we know if chlorine is affecting bacteria in the water well what’s what about all the eight pounds of bacteria in our gut. 

Israel Passwater: Yeah, it’s correct. 

Dr. Justin Marchegiani: So, it makes sense, we know 80% of our immune system is there. So, it’s gonna have negative impact with our microbiome, our immune function, so it’s good that we have ways to get it out.

Israel Passwater: Yeah. Especially if you’re immunocompromised too, that’s a real significant topic, you know, for people that are like yeah or just sensitive to certain things. You know, 

Dr. Justin Marchegiani: 100%

Israel Passwater: There you go. That’s our website, um, so

Dr. Justin Marchegiani: I just pulled up on screen first thing, we hit the, um, the first thing we talked about was fluoride, we talked about fluoride and the Hydrofluorosilicic acid right? Before Hydrofluorosilicic acid, we talked about, you know obviously the percent removal. This is great and this is all confirmed via lab testing is that correct? 

Israel Passwater: Correct. Yeah. That was the thing I was gonna touch on too. Whatever you choose, okay, so like, when I’m talking to people that may or may not know about us or have you know, a medium  interest in water, you know filtration, um, they say, well okay well, you know, how do you compare to brands x, y, and z and go okay well, we do actually if you go on our website, we actually have a few comparisons like how we compare to like, you know like Berkey, Aquatru or some these other brands that you know are might be larger companies might have you know bigger marketing budgets but they again, when it comes down to it, it’s all what is testing is proven to do and then how was it tested, where was it tested and that what are the standards. So again, the cool part about our, uh, filters is they’re tested at EPA and NSF, uh, certified laboratory. Uh, we test stuff all the time, we actually just recently updated our pitcher testing so like for now we’re, uh, up to 273 known contaminants. Oh yeah, that’s a cool video too if you have ever wanted to check it out like the red dye test. But it just kind of gives a powerful visual of you know what our filters are doing and again imagine the red dye being toxin xyz. 

Dr. Justin Marchegiani: Toxins, yeah exactly. 

Israel Passwater: Yeah. The cool part again, again our filters are tested. They work and again we feel we have the best option in the space or and again we’re not the only option but we’re probably the best, uh, as far as when you’re looking at water pitchers especially or our point of filter systems like our under the sink or inline filter for your refrigerator, I mean, we really in, again, we have bottles so we kind of fit in the niche of like between like, hey I don’t want to put in a whole house system because there are some good house systems like as you and I were kind of chatting about yeah, but I want something portable, I want something I can take with us, something I’m renting a house and I want to be able to have clean and safe water for my family, we fit in really well, there so. 

Dr. Justin Marchegiani: Excellent. Very cool. So, let’s continue to hit, so we talked about fluoride, we talked about chlorine which I think is really important for all the reasons, we mentioned chlorine right here 99.5 and also the chloramine which is a metabolite too so we’re knocking a lot of these down. Let’s go into the plastics. I think this is really important because of the microplastics so you have different plastic compounds BPA, various estrogen chemicals. You could probably put, um, pesticides, perforated chemicals in there, different chemical pesticides runoff.

Israel Passwater: Yeah. A lot of time, they think, well how do microplastics or like us pesticides end up in the water supply because when you think about it, you know, I see you know, neighbors of ours out there were like you know roundup  and which is equally horrible but they’re spraying killing weeds and stuff I got to go but what people don’t understand over long periods of time that ends up and seeps into the water supply and then again local municipal water department doesn’t necessarily have the tools in order to filter that out, you know, so again, the assumption of hey it’s safe or with microplastics  a lot of industrial runoff, you know, we build and create things and that ends up also in the water supply too so there’s a lot of different ways because of runoff and seeping and leaching over long periods of time that can come downstream to us and things that we’re just becoming more, uh, clear about it, more, uh intentional about, um, I think that what again why people go. Oh my gosh. There are actual pharmaceutical drugs or another one. How are pharmaceutical drugs..

Dr. Justin Marchegiani:  Exactly

Israel Passwater: Well and yeah

Dr. Justin Marchegiani:  Exactly. With a lot of these chemicals too, a lot of times they’re still like pecs, piping that’s plastic, there’s still some plastic piping. So, a lot of these things may be running through that as well 

Israel Passwater: Which are not BPA-free as we know so and yeah and again BPA is limping like all sorts of nasty stuff too. So again, It’s really just kind of like a systematic like, aha, moment like, oh there’s a problem with my water supply potentially oh okey tell me more about that and that’s typically where people like I said like gravitate to and again gravitate it doesn’t have to be us but again we are certified to remove more contaminants than most of your, your top brands, you know, so uh, again, we feel like we have the best big mousetrap to use the term you never talked about, um, and uh again sometimes, you know people ask me like about a compound, we haven’t tested for. I go, you know what probably but I can’t say it until we’ve proven it but again all of our lab test is available on the website, you can download it and take a look at it. So, the biggest thing, I would like to say too is like for anyone in that space and interested in that, do your research but ask, you know, if the testing data isn’t available on the company’s website or on the packaging, ask for it. If say, hey I want a copy of your testing data and a lot of they can’t prove that or it’s tested for five gallons or in-house. I’ve heard something on the radio today, you know, it was like yeah 4 out of 5 people said that they felt that better, I think it was like a like a protein powder or something like. I gotta go, I go, that’s a perfect example like oh trust me it works it’s fine, well we tested it in-house for people that are on the payroll, you know, so stuff like that, that’s what you have to pay attention to, you know.  

Dr. Justin Marchegiani: 100% Yep. That makes a lot of sense. Let me keep by hitting other things. So, we also just have general bacteria and viruses right, I know, that’s really important especially with what’s happening today in the world right, um, so viruses getting that out of the water whether it’s a Rotavirus etc. or just general bacteria, E. coli. Different various cysts, I know, parasitic cysts, Klebsiella, Giardia. These are all different microbes that could be in the water as well. Let me just show that here as well, that’s important. Tell me a little bit more about that and so you’re saying conventional water filtration, they’re not gonna be getting rid of some of these bacteria, cysts, viruses?

Israel Passwater: They won’t, because again they’re servicing like volume. So, one of the things you’ll notice too like when you first makes …, is that they’re again, it’s a catch-all. They’re doing, I would not say they’re doing there best, they’re trying to service a very large population because like at least here in California, is like, when they were building the infrastructure like yesterday, I assigned a new place ice hockey or driving on the freeway through L.A. and he’s going why are the roads so bumpy they go we’ll again because they’re old and they weren’t you know why are we hitting traffic well, they weren’t designed to service this many people. Same thing with the water supply. Again, when California’s infrastructure was built, you know, 100 years ago, it wasn’t planned. They weren’t planning on having this many people live or what again, great place to live, um, whether wise but gain from an infrastructure standpoint for water filtration like servicing a lot of customers and they can’t again. That’s why good filtration takes time, um, so like you know people know it’s like oh wow, how long does it take to develop your water pitcher, usually about 10-15 minutes. I go, oh wow, that’s kind of slow, no it’s actually good because it’s doing its job so, um, it really just depends on how you look at it but again trying to service a bigger catch, uh, a bigger net but against letting some of those particles and contaminants through because again, they can’t, they’re not set up to do that and that’s okay but knowing that you say okay well I gotta go take the next layer, the next step in order to protect my family and myself, you know, so

Dr. Justin Marchegiani:  That makes sense because it takes a while for water to fit through and if you’re trying to get millions of gallons out, it’s gonna be pretty costly and it makes sense to filter it source you know. I mean where it’s coming into the home so it’s most like that this should be just something that everyone should have anyway. So, they’re trying to make the water decently clean, so you don’t get really sick, taking it in but it’s still not gonna have the health properties that we need overall. 

Israel Passwater: Right.  And that kind of goes with the assumption of like, okay so like I have you know even if you have like a whole house system, some of them are rated different rates and some of them aren’t rated at all so it really like depends on it so again that’s the first step but the second step typically is like people like oh well I have a fridge, a refrigerator, LG refrigerator that’s got a filter and it has a light that goes on when I need to replace like filter and they say oh cool great and they asked the same question, oh well, what is the filter actually doing, they kind of have the deer in the headlights look like, I don’t know, I have no idea well it’s again the assumption of safety the illusion of safety is like oh it’s a filter okay it’s like a seatbelt was it crash tested, I don’t know, it’s the seat belt though, you know, so but again we wouldn’t again I’m kidding, it might be a poor analogy but like that’s the kind of assumptions that you walk around with like oh okay, it’s gonna filter okay cool. Well, what does it do, I have no idea but part is that we do have an idea and we can prove it.

Dr. Justin Marchegiani: Yep. And we kind of already highlighted the herbicide that is a big deal because of pesticide runoff. It’s coming in from different farms, it’s going into our water supply and again this is like a wide category right, I mean, there’s all kinds of organopesticides and these affect our nervous systems. They are hormone disruptors, so they can really throw off hormones. This is a big one right. Any comments on the herbicides at all?

Israel Passwater: Yeah. I mean especially typically when someone’s asking about the herbicides and pesticides, a lot we have a lot of mothers are asking about that they’re expecting getting out..

Dr. Justin Marchegiani: 99.99% out so this is great. So, this is really significantly reducing our reduction and just not cut you off but these things are really powerful at very low doses so you don’t need a lot of it to affect your body, right?

Israel Passwater: Correct. Yeah. They get effective dose on or the, the lethal dose but yeah it doesn’t take a whole lot in order to do a whole lot of damage, um, and that’s again a scary thought, you know. 

Dr. Justin Marchegiani: 100% So we talked about pesticides that’s important because we’re getting exposure there, I would say the next thing, um, we talked about pesticides and herbicides. They’re kind of the same camp, right? In the same camp there, I would say the next thing after that I think is really important, um will be medications. Can we talk a little bit more about the medications and like statins, antidepressants so if even if we just like pee right these metabolites are going through our kidneys and they get into the water, right? 

 Israel Passwater: Well, because you think, like how on earth could like this kind of stuff be in the tap water and then initially when we started talking about this, I go really there you go, that’s, that’s a thing well yeah obviously our body filters it through our own filter system and it excretes all the toxins that’s what your body designed to do but that also includes trace amounts of insert whatever, uh, pharmaceutical drug you’re taking, you know, so that stuff shows up in traceable amounts in the water supply and people are kind of shocked when they find out, you know, like roundup. Okay I see like, my neighbors sprinting around up on his on his yard or something about ant killer or whatever the toxic thing yeah, I can see that it rains it runs down the drain it goes into the water suppl, makes sense but pharmaceutical drugs, you think, how on earth that well okay, when we think of it from us being the carrier or at least the disseminator of that or if you’ve ever dumped pills down the drain or down the toilet that can also end up with water supply too. So again, there’s a variety of ways that happens, um, but it’s something that we need to pay attention to, uh and something that’s very easily overlooked. 

Dr. Justin Marchegiani: Yeah. I mean just looking here on, on the list that you guys are actually testing right deep. That’s insecticides or you know, uhm spray for mosquitoes, right? 

Israel Passwater: You think, okay like that makes sense. You know but some of this other stuff is like, like way hardcore you know. So it’s like..

Dr. Justin Marchegiani: This phenol A, obviously a plastic compound, a lot of the hormones that women maybe on which we don’t want men being on right?

Israel Passwater: Correct. 

Dr. Justin Marchegiani:  That’s like GABA medication, right? And then you have, um, just trying, I don’t recall some of these names, Naproxen, that’s some pain medication. 

Israel Passwater: Yeah. Again, I’m not a medical doctor, my degree in exercise physiology so like but again from a from health perspective, you think of all the things you do, during the week, you know, you know, like I’m a runner you know, it’s like, like training I’m running 60 miles a week, I’m stretching, I’m cross training, I’m taking some supplements, I’m trying to eat healthy and you know not drink too much or whatever it is you’re trying to do but again an easily overlooked one is like what, how, not just how much water you are drinking what kind of water are you drinking so that’s where really people go, oh, yeah you’re right, you know pesticides as we see, you know, its like, you know, those kind of things. They’re there, there proven and uh, I don’t know if you’ve shared with your audience 

Dr. Justin Marchegiani: For this handout people here, this is uh, anyone listening we have some stuff on the screen shared here. This is the actual lab assessing assessment testing on 100 gallons. This is cool. So, we’re seeing this is also getting removed like we know it and so on the website, you, kind of have it here right, you, kind of have it oh, you had it listed here, what was being removed but then we actually have the lab assessment here so that’s cool. 

Israel Passwater: Yeah. Yeah yeah.  And again, yeah, we’re going to be adding some features on the website so if you look over the next week or two or three. It’s gonna have some other tools that we’re adding not to tease it but again we, the way it kind of the way I see is like, you know, from not just like we’re not selling water filters will help them educate people too that’s obviously why you and I are connecting on the podcast today but I think it’s important to if you take away nothing else from this podcast other than, hey I maybe need to rethink what other kind of water filter or if you’re not doing it, go do some research and find out some of the ones that’s best for you because again like what I said we’re not the only company that does this but we’re the ones that do it, obviously a greater extent, um, and again we’re decently in our opinion very affordable, easy to work with, um, independently tested and certified. So, I can, I, I see it’s kind of a no-brainer but it really starts with in an individual saying, you know what let me think about that, let me see what, what is my fridge filter is doing or is it doing

Dr. Justin Marchegiani:  Exactly. Yep. That makes sense. That’s good. I like that. So, we hit the fluoride right and get a big one, we hit a lot of the viruses and bacteria stuff and then we hit a lot of the plastic compounds we can put, like phthalates in that category, we have to put microplastics in that category. 

Israel Passwater: I’m trying to think of any, like the top offenders too, like for people but again you know, fluorides usually where people like or in heavy metals or where people start you know like..

Dr. Justin Marchegiani: Pharmaceutical drugs, right?

Israel Passwater: Pharmaceutical drugs, radiological elements, obviously, that’s one that we do too but I mean it really just depends on like everyone has a different you know top of their pyramid, they also have a different fear points here so they like whatever is most fearful of them or what’s most recent as far as exposure or you know, you know whatever that is again, we can service of those needs you know so and occasionally someone will say, well what about this and go well if we’re not certified to remove it we won’t claim it because we don’t know. 

Dr. Justin Marchegiani: Yeah, that makes sense.  

Israel Passwater: And it’s also too very costly and very timely to do this, so it’s not like we can’t just run down the street and have it done, it’s like no we have to have it send out and it cost thousands of dollars and so we’re very intentional about the ones we test for, um. 

Dr. Justin Marchegiani:  Exactly. Yep. That makes sense. And so just kind of the big five, right, we have pesticides-herbicides, we have fluoride, we have chlorine, we have pharmaceutical drugs, right and we have a lot of the you know, heavy metal here as well too, mercury, lead. These are important right, a lot of pipes used to be lead, I mean there’s a reason why, um, plumbers are called plumbers, I think, what is it the periodic table for, uh, lead, I think it’s plumbum is, is lead, right? How, that’s I think Latin for Lead is like plumbum the, in the periodic table of elements Pb which stands for plumbum and that’s what plumbers got their name from because plumbers dealt with pipes that were literally lead so lead pipes and plumbers were kind of synonymous, so it makes sense there may be still old piping out there in certain areas so you want to make sure you’re pulling the lead out, pulling any mercury out, pulling any, uh, compounds out that could be problematic. So heavy metals, pesticides, plastic compounds, uh, then we would have a lot of our pesticides and then chlorine fluoride. So those would be our top five here today. Anything else you want to talk about regarding other problematic compounds we didn’t dive in deep enough on?

Israel Passwater: No, I, I think I would just encourage everyone there’s a fun open-source tool they call the environmental working group that’s the EWG. They actually have a database where you can pull up your zip code. So, you can punch in like mine’s 19694 so you know where I live now, but it’ll pop up but hey here’s the, the compounds that we found in your lab testing. Yeah, here we go, perfect.

Dr. Justin Marchegiani:  Yeah, here’s mine. This Austin, right here. This is Travis country, so you can look here, we see, 

Israel Passwater: Like, well, let’s see, like oh, there you go, yeah and again and also too I wanted to mention that a lot of these substances are regulated by the EPA, so they say well, you know, the EPA is there to protect us and they are but again a lot of these things aren’t regulated or if it’s regulated it’s not to a healthy extent because you shouldn’t be like chlorine, you shouldn’t be ingesting chlorine but it is regulated so

Dr. Justin Marchegiani: Right, and then if we go here. Let me go pull this back up, right and we look at some of the testing, so we so in my area, I think the big one we saw was a lot of bromines, so there’s bromo, your bromochloroacetic acid, that would filter that out and we, I think we saw a bunch, um, you look at what else we saw there, the chloroform, so that that’d be that’d be your chlorine, right? 

Israel Passwater: Right. Correct. 

Dr. Justin Marchegiani: Over there. 

Israel Passwater: And that’s the kind of the fun part is because you can thumb through and our goal is to be as transparent as we can, you know, so like I said, if there’s something we haven’t tested for, we just said, you know what we haven’t done that, we’ll put on  a list, you know, and were  constantly building a list and we’re constantly retesting you know, like I said we retested our pitcher, uh, this year and we’ll be doing the same thing with our inline filters but again, everything were certified to do, is like what we have proof of you know and it’s like yeah

Dr. Justin Marchegiani: Here’s your chloramine and here’s your, uh, your chloride. So, it’s then you can kind of go in there and say, okay cool like at least have some coverage, um, for some of these issues, so that’s good and high levels of chromium too. 

Israel Passwater: And yeah, I just want to mention, so this information is getting pulled from the universal database, so EWG just proved like, compiles all the data and then kind of google and then it kind of presents it in a very, uh, I think eye-opening way, um, so one of the cool parts is that you say well if you don’t believe me that your water supply is there’s probably something to be worried about, go here and then they’re a non-profit, we have no, we don’t paid by them or anything like that. So again, I like to show that is kind of like for someone who maybe new on that journey, um, towards, if either finding us or finding something else, say you should do something because you should consider this and that’s usually like, oh my gosh, I can’t believe that. 

Dr. Justin Marchegiani:  That makes sense. That’s great. I want to just compare the technology to like you know your general breeder. I’m on your site here right. Where’s the best way to go see that, I know that you have like a comparison on here. Is it a featured pitcher? Is that right side?  

Israel Passwater: Uh, yeah. The comparison I’m trying to think about the comparison, it already should, I should know this. 

Dr. Justin Marchegiani: I went, I went through here earlier and I saw it and I thought it was really good. So, I’m gonna, I’m gonna put her around here as we, as we’re chatting to see if I can pull it up here. 

Israel Passwater: And I’m trying to think, I, we have like a blog session, a session section, excuse me, that like really showcases, like, some interesting articles like us versus Brita versus Aquatru, us or Insert brands. Again, like I said we’re not the only people that do water filters but again kind of goes through like, how we’re.. 

Dr. Justin Marchegiani: Here it is. Right here. I got it right here. So, there’s, you know, you clearly filtered standard carbon, zero water, so let’s just kind of go through the big thing here. So the big one is obviously fluoride, microplastics, lead, a lot of the, um, the I think these are volatile organic compounds, right here. So, we’re really filtering a lot out so most are going to do pretty good. In regards to what’s probably more lead and then what else. Let’s, let’s use the easiest one, one of the easier ones to test for too and you know if you have any carbon block filter of any type, it should remove some percentage of that. So again, we never want to just like, to discourage other brands, that’s never my thing, it’s like hey whatever you are, you’re using even a Brita filter for example because they’re the most know brand because they’re been around the longest and they’ve had the most like a said the most marketing budget for longest time but again, it’s going better than drinking tap water, so it’s definitely better amount of good so that, which is a good thing you know so it’s like you know, hey well, you start here and then you move here and move up, you know, but uh, I think too, one of the things that keep in mind too is like, uh, when you’re looking at comparing like, brand A to brand B to brand C. You got ask yourself, you know, three main questions: how is it tested, is it tested, those are two parts and then to what degree, who’s testing it and then also to the other part is how long does it last, you know how easy is it to work with, you know, is it made domestically or is it made overseas that’s the one thing to consider, um. Again, all very important questions to consider when you’re looking at but I think the biggest thing is transparency because there’s a lot of non-transparent, uh, practices and a lot of unregulated. So, we try to be as up like I said as upfront as we can about with people and I think they appreciate that, you know, I do.

Dr. Justin Marchegiani: It’s good. That’s good. Let’s talk about kind of what like the technology. So, if someone’s researching a brand, someone’s saying I want really investigate a water filter and what makes a water filter great and they want to look at different brands what should they be looking at. So, let’s kind of compare and contrast using the technology you have, how would you know, you’re dealing with good tech? Let’s just kind of contrast what you have and how people should be educated on this. 

Israel Passwater: Yeah. Yeah. Great question. 

Dr. Justin Marchegiani: So, I’ll put the screen back up here so you can, you can kind of use that as a guide to walk through it. 

Israel Passwater: Yeah. Thank you. Yeah.  That’s fine. So again, our technology, it’s, it’s our own technology. It’s affinity technology, we’ve spent tens of thousands of dollars in multiple years coming up with the filter, uh, yeah, so we actually ever realized what was made up. Well, we don’t disclose the ingredients list but again we’re not using activated charcoal or bone char or anything that’s going to be problematic so it’s all, it’s all up and up and obviously if we’re tested so we need to update that graph, by the way sorry, um, you’re constantly finding things but yeah again the technology basically the way this simple elevator answer is your water supply or your water, uh, your water supply is polluted, we have a technology to remove it. Takes out all the bad stuff, the toxins, the chemical, the PFAS, the lead, uh, the VOCs, and retains the nutrients in the water so that. that’s the secret. So, a lot of times even when you look at like an RO system, RO systems aren’t inherently bad they pull everything out of the water and then a lot of that they added back in the salts and stuff like that. But the cool thing is like, with our filters is that we have the ability to remove all the toxins, so our filters are smart they’d be able to discriminate between filter or sorry between water, uh, nutrients and then toxin. So, that’s really where people go wow, that’s pretty cool and it is. It’s awesome. Like, I said, we put a lot time and energy into that, our design team is constantly working on ways to innovate, uh, we have some new things coming out that I can’t quite share yet but, um, things that I think will be really well received and making a little bit easier for our customers. But the big thing is, we know how to remove the bad stuff keep the good stuff in and the other stuff too, oh yeah, like I was saying, like with the RO systems, uh, they’re about 75% less water efficient, so for every clean gallon of water, it makes, it wastes three and a half gallons. So, for us, we don’t do that. So, we’re also eco-friendly, um, again all of our stuff like you see, our testing data is fantastic. Uh, it’s independently third-party test and lasts a long time. So again, we see it as like a slammed up for the right person who’s obviously open to that, um, but again when we’re looking at different types of filters, you know, yeah like I was mentioning, like our pitcher filter, it takes you know, 10 mins to fill the reservoir. Well, it’s doing its job. So sometimes fast is not a good thing. So 

Dr. Justin Marchegiani: Exactly! I love the, the water pitcher because one, it’s not expensive at all, especially when we know how important water is to our health. This is like, it’s just about prioritizing our health and knowing that 70% of your body is water and making sure it’s clean, right? You’re literally swimming in your water and if it’s clean then that’s great, if it’s toxic then it’s poisoning us, that’s a problem, and some people are in apartments and they’re traveling they haven’t the ability, so I love the ability to bring it with you and just put it in your fridge. So, I like this as a great option here. Can we talk so like, talk to me about the technology, so we have phase 1. There’s some kind of a medium, it’s flowing through like other brands are using charcoal or bone char. You have your kind of medium that’s a non-toxic medium that it’s, it’s moving through and then what’s, what’s there after that, like what’s the next step? So, there’s some kind of a filtration medium. What’s the next level up after that?

Israel Passwater: As far, as far as our filter or other yes

Dr. Justin Marchegiani: Yeah. Yeah. Well, it’s just for yours and then in general. What would other people have? 

Israel Passwater: Yeah, I mean, it’s again, think of layers, so it’s like, you think of like a layer cake, it’s just. 

Dr. Justin Marchegiani: So just, I got the image up so we have like a woven mask, some people would have the charcoal with a bone char because that’s kind of step one, right?

Israel Passwater: Yeah. And then go to step 2, you can scroll through and then

Dr. Justin Marchegiani: So, then you have your coconut carbon

Israel Passwater: all right and then you go to step 3 and then combine the shell, kind of like holds it together and stuff like that. So again, it’s again, even if we gave you the ingredients list like coke for example, like no they, they keep that under lock and key, what’s the secret, you know recipe for coke, we know right, right part of the sugar, part of this diet, the other thing but again we can give you the ingredients list but the way it’s put together that’s really what comes together. So again, not the first people that come up with the idea like this but again we have the best one. So, uh, but again think of like a meshed layer that can woven together and again it’s how it’s put together and what stage and how it’s composite in and what not. I can’t say much more than that but again, that’s right

Dr. Justin Marchegiani: So, so most people are just primarily having this stage 2, right? It’s a kind of stage 2 thing or

Israel Passwater: Yeah. Yeah. 

Dr. Justin Marchegiani: You kind of have your pattern on page one. 

Israel Passwater: Yeah. Right. 

Dr. Justin Marchegiani: With your mesh and then you have the stage 2 and then you obviously your stage 3 compartmentalized at all. That makes sense. 

Israel Passwater: Most part, you’re not gonna take them apart inside like how is this put together it’s more like how fast is it doing, is it doing it and does the water taste good, again that’s just literally like the way I would have looked at it before, we started clearly filtering like, oh, okay, it goes, it’s going through, it’s not leaking, it’s not gonna leak into the reservoir. Okay great. Awesome. But again, stage 2 up for like a coconut carbon, it’s just like a block of, it’s gonna remove some stuff. That’s better.

Dr. Justin Marchegiani: And then we have all of our test results so we kind of know what it’s doing, that’s good. I like it. I think it’s great. If you guys wanna, if you guys enjoy the information and you wanna have an additional level to clean your water, justinhealth.com/clearly-filter. We’ll put the link down below, um, we’re just trying to provide a lot of education for everyone because, you know, I see a big gap in this field is, I recommend a lot of under the counter whole house systems but there’s a lot of people that, that can’t do that so this is a kind of a better mousetrap in that way, um, and we know water is so important. Anything else that, you know, Israel, that we talked about today, we didn’t go deep enough in, that you wanna highlight?

Israel Passwater: Yeah, no, I, I think one of the things too where we play really well is like you’re saying like on the go for people living in apartments and stuff like that. I think for, you know, just a skim, even when you’re traveling that’s why you’re getting more bottles you’ve got to wear filtered bottles which are kind of cool.

Dr. Justin Marchegiani: Oh, you got a bottle too? See a filtered bottle that you can bring with you to. That’s great. 

Israel Passwater: Which is good because like you know, my wife and I, we went to Hawaii for work, uh, a couple of about a month and a half ago and it’s like we brought our bottles and I actually brought a pitcher because I go, I want that convenience it actually fits into the refrigerator for like you know a Hawaii size you know, uh, refrigerator. So, I was like, that’s pretty cool, so you know again, we played really well for, for we offered the service then obviously you know great technology, great customer service, um, again, transparent, easy to use, easy to work with and again you know that’s really why I think kind of fun part about us, helping people live healthier lives is that where it, it’s easy to do so

Dr. Justin Marchegiani: That’s cool, so you got a portable bottle as well with that same mesh and activated charcoal technology that still filters out a lot of that while almost all the fluoride, all the chlorin, heavy metals, so it still has similar benefits as the actual. That’s great.  Wow. 

Israel Passwater: Yeah and most people like because they think like okay well I’ll have to fill up, you know, they have refilling stations at your gym, there’s nothing wrong with that but again they’re they have a filter on it but we’ll kind of filter it well, I don’t really know exactly and that’s where you think, well, you don’t have to worry about that it’s like or if you’re going to the airport now,  that people are traveling now, hope it’s kind of helpfully winding down, you know, it’s like yeah and now that people are back to going they’re really focused on that, so that’s something that you think from an economic standpoint and typically, uh, I believe the stat was most people are spending about 1200$ a year in bottled water so you gotta Costco get the coarse blend, you know, 24, 36, and 48 packs, that’s a lot of money savings too so again if it’s money if it’s you know obviously chemical reduction, uh, indigestion, that’s, uh, something that we can definitely help with, you know.

Dr. Justin Marchegiani: That’s really good. Well in general, I think really important the solution to pollution is dilution. So you wanna have good clean water. Your cells need to regulate temperature, to pull toxicity out, run to help run our kidney, so really important to make sure kind of as a foundational right, clean food, clean water, good sleep, good movement, these are essentials to being healthy, so here’s another great product that I recommend, that recommend for patients and use myself that I think people would benefit from. Anything else, Israel, you wanna leave the listeners with? 

Israel Passwater: Yeah, no, I think the biggest thing is like, you know, where if, if they’re interested in, you wanna choose, that make sure you did your research like do your homework and that’s with anything if you talk about supplements, uh, anything again, we read you know the back of packages, you know what I’m eating, so the same thing goes  with like water filter so if it’s just us or somebody else, do your homework. Make sure you’re getting into, uh, I think that and we will shine after that but, uh, I think I really, it’s more just like I just again always encourage people to do their homework, think for themselves, question everything and that’s really important because again there’s a lot of misinformation out there or lack of transparency, um, so that’s kind of one of the downsides to our industry. It’s not very straightforward and so you really, really dig into the weeds there and again we’re busy too, I mean I work full time, my work works full-time, you’ve got a life, you’re trying to work out be healthy, you know, all those things but again, if you’re gonna invest in yourself, you can definitely want to make sure, you know, what you’re doing, you know, so if that goes with anything we’re not the whole piece of the pie but we are one piece of that, that’s overlooked like. I said, you know. 

Dr. Justin Marchegiani: Well, yeah. A lot of people that already are using a simply, you know using a filter already and it’s just we’re gonna exchange it out for something better that’s gonna clean the water better and then also I always tell patients, I’m not worried about stripping minerals out, they’re always, they’re already good supplements out there, where you can pinch a little bit of minerals back in. It’s easy to re-mineralize, it’s harder to pull out toxins. 

Israel Passwater: Correct, yeah, correct. And remember, yeah like I said it’s a lot easier to do that than the opposite, you know, so that’s why obviously, we’re around and that’s why it’s something, the way I think it’s like, it’s one less thing to worry about, um, so if you worry about stuff being a parent, you know, being a healthy or not then you know, this gives you. One less thing, you know, have to consider, you know, if it’s at home on the go so. 

Dr. Justin Marchegiani: Anytime you can set like your health habits on automatic, like okay I’m just plugging this in and then I’m just gonna continue with my routine and then now, I have a higher quality food or higher quality water, you get the benefit, right? The more we can set these habits on unconscious competence where it’s just automatic, it’s always better. I love that. 

Israel Passwater: Yeah yeah and then one thing on the automatic too that, we’re talking about easy to work with, again, we have a subscription service so again, we ship domestically for free, uh, for anyone on our, uh, subscription and, uh, basically, the cool thing we need to talk about like not having a room with things I forget everything, you know, so I have to have everything written down or a calendar reminder, uh, but the cool part is you know, we can put it on auto ship so if you want one every two, three, four, five, six months, you control them, so the cool part is like that ability to be able to choose not to have to think about it or if you need to push it back, they can do that so again, we make it super easy for you, um, again, we have really great customer service team and we take good care of everybody, so  I think again, that’s one less thing that I have to worry about, you know, imagine like, you know you have that with entire rotation, somebody automatically does that for, you instead of having to go down,  the entire shop, get the oil change and entire rotation so we want to make it easy on you, you know but, um, that’s also powerful to know that you have full control of that too, so

Dr. Justin Marchegiani: Very good. Anything else, Israel, you wanna leave enlisted with? 

Israel Passwater: No, I just thank you for your time. I’m really, I’m excited, I’m glad I get to be part of your audience and uh and here with you guys today and if they have questions, um, I don’t know if you want to funnel through you to me but they can, I can give you all my contact info, you can share that later too. I’m happy to give a resource to you, if I can and yeah

Dr. Justin Marchegiani: Any questions you guys, put them in the comments that’d be awesome. You can always come back around on the youtube video and respond back and if you guys enjoy, I’m always trying to hunt down good products and this is definitely one we can add to that list. Everyone and then justinhealth.com/clearly-filtered and I’ll put the link down below. If you’re driving just go down below, first link, click it and you’re good. All right, Israel, phenomenal chatting with you, thanks for dropping all these knowledge bombs and have a phenomenal day. 

Israel Passwater: Thanks Justin, good to see you man. 


References:

https://justinhealth.com/

https://www.evanbrand.com/

Audio Podcast:

https://justinhealth.libsyn.com/the-top-5-ways-your-water-could-be-hurting-you-how-to-fix-it-podcast-350

Recommended products:

Clearly Filtered

Water Filtration Device

Whole House Water Filter

 

 

 

 

The Nuts and Bolts of Your Mitochondria – How to Enhance Mitochondrial Function | Podcast #349

Have you ever thought about what powers are inside your body? In this video, Dr. J and Evan talk about mitochondria and how to boost them.

When we talk about your body’s powers, the easy answer is nutrients, of course! Our body transforms those nutrients into energy, and it’s that energy that boosts the cells in our body. All types of cells have small generators called mitochondria that, in many ways, are their sources for life. Mitochondria are the only part of the cell where our basic life requirements — food and air — are combined to make energy in a process known as the Krebs cycle.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

0:00:      Introduction
1:30:      The role of creatine in mitochondria
6:34:      Energy pathways
14:47:    Cell Danger Response
16:07:    Citric Acid Cycle

Dr. Justin Marchegiani: Mitochondrial function, your mitochondria, little the powerhouses in your cell and they help generate ATP which is the cellular currency of energy so to speak. And we’re going to talk about natural ways to improve mitochondrial function, Evan, and how we doing today, man.

Evan Brand: Doing really well. I think first, let’s dive into some of the big assaults that we have as a modern society on mitochondria. And that could be anything from viruses, bacteria, parasites, gut infections, pesticides, herbicides, heavy metals, plastics, phthalate’s, the BPA, the BPS, flame retardants, nonstick chemicals, car exhaust, air pollution. That I miss any I mean.

Dr. Justin Marchegiani:  Like you hit a lot of I would say being sedentary. There’s a lot of mitochondria in your muscles. And if you don’t do enough, you’ll put enough force to those muscles, they will atrophy. And so just not doing enough about creating enough stimulus on your body. That could definitely we can and decrease your mitochondria in your muscles. So, I would say, sedentary and in active resistance through your muscles.

Evan Brand: OK, OK that’s a good point.  That’s a good point. So, you’re saying that, like, just in general, you have to have some level of physical stimulation physical activity to keep the mitochondria working. I guess it’s kind of like an old car that you’ve sat there…

Dr. Justin Marchegiani: All your muscles at least. Yeah, ’cause if you decrease, you know your muscle levels via just atrophy due to lack of use. Yeah, your muscles will shrink absolutely and that’s your mitochondria will shrink for.

Evan Brand:  Sure, what about creatine? Do you know anything about the role of creatine in mitochondria? ’cause I know when I’m taking creatine, I just I feel stronger? Obviously, there’s creatine’s used a lot in like bodybuilding world, but there’s gotta be a mitochondrial mechanism there because I’ll tell you I feel like. I can lift, you know, at least a good 1020 pounds heavier on particular exercises with creatine in my system.

Dr. Justin Marchegiani:  Yeah, me crazy definitely has an effect on growth hormone and improving growth hormone stuff that will help with muscle. Creatine is like instant energy for the muscle. So, it’s it’s there. It’s ready to be used right away in that first 10 seconds or five, five to 10 seconds of muscle use or like explosion movement through that muscle. So, that definitely plays a role in muscle. I’m not sure how it plugs in 100%. I see ’cause really you know with ATP right in the mitochondrial function? If you look inside the mitochondria you have glycolysis and then you have the electron transport chain. Or I’m sorry, you have the Krebs cycle citric acid cycle and that plugs into the electron transport chain. So, glycolysis that’s going to be utilizing the carbohydrate in the muscle right glycogen in the muscle. Fast immediate source. I think creating plugs into that top part. And then you have the Krebs cycle citric acid cycle, where B vitamins, magnesium. All these different things kind of plug into that and with that. With the citric acid or Kreb cycle, that didn’t mean the same thing. Essentially, they’re grabbing hydrogens, right? So, there it’s it’s a reducing agent, so it’s just grabbing reproduce. Reduction is a gain in electrons and so you have NAD goes around. Then it grabs NADH so you get 3 NADH and I think 1FADH2 so you have FADH. And it grabs another hydrogen and that becomes FADH2, and so it’s grabbing all these hydrogens. And then it’s essentially bringing those hydrogens downstream into the electron transport. Jane and Beta fatty acid oxidation there and so yeah, I think you generate was at 36 to 39 ATP through the Krebs cycle and the electron transport chain.

Evan Brand: Unless you’re in like chronic fatigue stayed, this cell danger response, and I think you’re spitting out something low like 2 maybe 3 ATP. I’ve read about this cell danger response. They just call it HDR in the literature, but it talks about how. The cell danger response, could be initiated by trauma or a car wreck or even mold exposure or tick-borne illnesses, or viruses. There’s a lot of you know, Epstein Barr. You’ll see the link between like mono and chronic fatigue. It said that these people are in this state of just a low power output, or even if you have the nutrients, you’re just not generating the ATP with some I don’t know if it was Caitlyn or somebody that you and I had looked into where there was a talk on this about. How the w the the ATP was literally in the single digits. The low single-digit output in some of these states. So, the message here is that for people that have chronic fatigue, you got to realize there is a mitochondrial component to this. Why don’t we talk about testing a little bit? The main thing that you and I are going to look at is going to be the organic acids. I know there are some other tests out there. I’ll admit I’ve had clients send them to me such as the mito swab. I’ve not run the model swab. Personally, I don’t know enough about it to speak on it much, but I’ll just say that it does exist. I believe it is a a mouth swab and it’s probably looking at just a couple generic markers in the saliva. But we like to use the organic acids test because, as you mentioned, there’s the Krebs cycle metabolites on there. We can look into the supinate or what some people call succinic acid. You’ve got the malic acid. You’ve got fumarate. There are other markers on there, and we we see when people have talks and exposure. Like I said in the beginning, the heavy metals, the mold, the pesticides will see those. Mitochondrial markers go up. And the higher the numbers go, generally, the more tired someone is because that indicates more damage to that Krebs cycle. So, the oh is huge, and then obviously we’ll look at stool too. Now the stool test you don’t measure like the stool tests we’re running. You’re not measuring mitochondrial function, but I look at it in a roundabout way. Meaning if you have all these gut infections producing toxins that could be damaging mitochondria as well, so we know that when we clear the gut out, we see the mitochondrial function improve.

Dr. Justin Marchegiani: 100%. Yep 110%. I want to just put something on screens. People can see it here I guess is really helpful.

Evan Brand: Have you seen or heard about that my to swab before? Have you seen anybody send you those?

Dr. Justin Marchegiani: I have, I’ve ran up. Fulham, it’s kind of a binary test. It gives you a result my the issue I have it’s not a lot of actionable information. It’s like OK, you know there’s some issues there, but then now what’s, what’s the remedy that you’re going to plug in from a diet lifestyle supplement? Toxin reduction execution right? What’s the next step on it? So that’s the problem with some. Of those tests, I always. Look and I always ask well what’s the corrective action based on the test showing uses a concern.

Evan Brand: Yeah, yeah

Dr. Justin Marchegiani: That makes sense.

Evan Brand: That’s the problem with a lot of them like I’ve seen a lot of these stool testing companies. Same thing there’s like so much data. Well, this percent of this bacteria and this percent of that. It’s like, what do I do with that? Is that an infection? Is that not an infection? So you and I’ve seen the same problem in other categories of health tests do.

Dr. Justin Marchegiani: 100%. I want to show a couple things on screen here? Just so it’s crystal. Where the mitochondria is and how all these different energy pathways plug in, I think it’s important I’m going to pull it up here on screen in just a second so people can see it.

Evan Brand: Yeah, people listening on audio, they’re going to be lost. So just look up Doctor Justin YouTube page and you’ll be able to view some of this stuff. Some stuff, like mitochondria, gets a bit geeky. The the main thing here is toxins are a big factor in damaging this cycle and you gotta get toxins out. Reduce exposure where you can and we can run actually chemical test on your current too so we could talk about that in a minute.

 

Dr. Justin Marchegiani: Absolutely, and so if you look here right. Do you have the mitochondria right here. Some middle part, the mitochondri. The outer part is the cytosol.  So, from what I understand, like creatine is going to plug more into the cytosol and glycolysis, OK, but then you’re going to see you get about two ATP which is adenosine triphosphate. And this gets broken down into ADP and you get energy right? And so, you have glycolysis which generates a little bit of ATP 2. And creatine to plug more on the outside then that goes into your mitochondria. Now you have the Krebs cycle and the electron transport chain electron transport chains part of also the beta fatty acid oxidation. That’s how you burn fat for fuel. OK, so Krebs cycle that churns around twice, and essentially what you’re doing is you’re gathering NAD and FADH2. NAD&FADH are grabbing hydrogen so and a design to grab a hydrogen making NAD. HFADH is going to grab a hydrogen, making FADH2, so I think you’re going to grab it’s like two or three. NADH is, and then one FADH2. And all those hydrogens then go into the electron transport chain here and this is where you generate most of your ATP. And again, what comes out, oxygen comes and this is why, if you’re like anemic right? And you’re not carrying oxygen. Well, that’s why you’re going to get tired and this is going to have an effect on your thyroid and your adrenals because the mitochondria is important for energy at all levels. And so if we have anemic issues or were inflamed because inflammation is going to make it harder to carry oxygen all. And also nutrition, because this electron transport chain, when we run the organic acid test, we can look at citrate, malate, fumarate, succinate. These are important metabolic essentially inputs into the Krebs cycle that correlate with certain nutrients like amino acids, alpha-lipoic acid, magnesium B vitamins, and so we can get a window on how this. Krebs Cycle was functioning based on the organic acid testing at some of those compounds and then all sister connotate citrate, right? These are really important, and then electron transport chain we can get a window into things like carnitine and Co Q10 ’cause they also play a major role in the electron transport chain. So we get a good window with how the mitochondrial function functioning by looking at the B vitamins and looking at a lot of these nutrients and so essentially things that can impair this. As you mentioned, pesticides. Heavy metals, mold toxins, antibiotics, and all these things have a negative impact. But that’s kind of how things look, so we have. Glycolysis is the first part that then goes into the mitochondria, and then we have Krebs cycle and electron transport chains. These are the big three. If you can kind of zoom out and see how it looks and how it makes sense. That should hopefully make more sense, so on that front. Any question that, Evan?

Evan Brand:  Well people listening to that. They’re going to be like wow, this sounds like a really crazy rare problem, right? This must be just rare. This must be like a one in million case and I would say. Not going to say 99. I would say 90% of the people we work with. I see some level of mitochondrial dysfunction or damage either on the chemical profile test, so that’s something I alluded to earlier. We can run chemicals so we can look at gasoline. We can look at xylene. We can look at phthalates, all sorts of organophosphates. 24D is a major herbicide. I still see people at Lowe’s and Home Depot in the Garden Isle buying grass seed. That’s called weed and feed, weed and feed is a grass seed mixed with three different types of herbicides. It’s 24D, I believe it’s dicamba and glyphosate. Wait, I could have mixed one of those up, but either way, it’s three different chemicals, very toxic substances mixed with grass seed, and that’s like people just buy it and they don’t think anything of the term weed and feed. That means you’re going to be killing all the good stuff in your soil and poisoning yourself at the same time. It’s just not smart. So this mitochondrial thing. My point was, this is not rare, like when you show that image and people see that like. Oh no, that’s not happening to me. It’s like it happens every day, all day. I had mitochondrial damage, my latest test shows our mitochondria are much, much better, but I had significant mitochondrial damage from my mold exposure.

Dr. Justin Marchegiani: Very interesting, I want to highlight one thing here so you can see creatine does primarily exist here in the cytosol, right? So if we zoom out, right cytosol is outside of the mitochondria, right? Right glucose, pyruvate here, so just so you guys can highlight here, creatine does go from the cytosol and it can go into the mitochondria. So, we did talk about creatine. It does primarily happen more in the cytosol outside the mitochondria, and it can go in via this. Mi-CRT kind of transport. Compound, so yeah, so creatine is a compound that we talked about that goes outside but can also go inside the mitochondria. To yeah Doctor Neil Nathan.

Evan Brand: That’s awesome! Doctor Neil Nathan did a huge thing for 155-page slide show that people can look up just called the Cell Danger Response. It’s very complex stuff. There’s going to be maybe a few geeky on that. People want to dive into that, but for your average person there’s not much takeaways built into that. But if you want to look into more of like the biochemistry side of it, then then you could look at it. But I think the big summary is it’s all. It’s all the Chemicals, and this is a relatively new problem I mean we face now over 80,000 chemicals are in the environment. Depending on what number you read, there’s only a small amount of those that are even tested. You’ll see stuff in Europe like oh Europe has banned these chemicals and makeup and personal care products, but the US was very far behind. And if you look at the environmental working group, they have a water testing report. You can look at and you can plug in your zip code. I mean just the amount of trihalomethanes’s pesticide herbicide residue pharmaceutical drugs that are in the municipal tap supply in your city are massive and you’re getting hit with this all the time. If you go to a restaurant and you eat rice, what do you think they make that rice with? They make it with tap water so you’re getting exposed to it that way too, which is why if I go out to eat, I don’t really do rice that often anyway. But if I do it, It’s going to be at home with good, clean filtered water.

Dr. Justin Marchegiani: I like it. Anything else you want to say on that, so obviously get the toxin exposure. Super important hydration obviously really important to anything else you want to say on that?

Evan Brand: Yeah, you hit you hit the the Co Q10. You mentioned some of the markers we’re going to look at on the oak test, so we will use those. We have a formula. I believe you’ve got 1/2 mines called my to boost. It’s essentially like a multi for the mitochondria with all the Co Q10, ribose, carnitine B vitamins. So, when we see mitochondrial dysfunction, we can supplement that and we tell people this is a band-aid for your mitochondria. This is not some of it is the root cause, right? If you just are simply low and depleted in Co Q10, one could argue supplementing Co Q 10 is the root cause, but in reality it was usually. Oh here we go. Let me see if I can share this slide with you. Mainly it was the the toxins that led to this so let. Me share my screen really quick.

Dr. Justin Marchegiani: And there is going to be because we do make Co Q10 on our own via the mevalonic acid pathway. And of course, as you get older, just like stomach acid, you’re gonna make less of it and so there there could just be a depletion based on age as well.

Evan Brand: Does that show up at all on your side? The video is that screen share show.

Dr. Justin Marchegiani: Try again.

There’s like a little bell there. Let me let me pop it up again. How about that, yes? Oh yeah, let me let.

Dr. Justin Marchegiani: Me highlight it, go ahead.

Evan Brand: Yeah, there we go. So, this is this is kind of what I was alluding to, and many many other people may have different ways to look at this, but this is from Neil Nathan. He had a great paper on this cell danger response and it just shows at the top here. Basically, everything I already mentioned like a flame. Heavy metals, pesticides, infection, so that would include viral issues as well. Mass cells, NK killer cells, cytokines, the microbiome. All these issues here are what really breaks this role. You know, the one of these is the final straw that breaks the camel’s back and then you end up in this what’s called the cell danger response phase. And then that’s where you get the issues with the mitochondria down regular. So there’s more in that. Like I said, it’s 155 pages. It’s like you got to be, you got to be, you know, have your bulletproof coffee before you look through that.

Dr. Justin Marchegiani:  No, that makes a lot of sense, so your kind of really focusing on the toxicity and how that negatively impacts it. I want to just kind of tie in the dietary component. Why is food so important to enhancing the mitochondria? Let me let me break that down for a second here. This is important. OK, so this is really important. We talked about like Kreb cycle right? And so like this is our zoom out right? What’s happening here? We have glycolysis, Krebs cycle, electron transport chain outside of the mitochondria with the cytosol inside. Now check this out. This is a good one. This is from textbook of functional medicine, so. We have fats, carbs and proteins. These are our primary nutrients where everything comes from right. Fast could be coconut oil, grass fed butter could be fats from. Uhm, grass fed meat right? Our carbs can be vegetables, fruit, starch and our proteins could be protein powder or it could be animal protein, right? All of these essentially shuttled downstream. Fats get carried into the mitochondria via carnitine, so if you go into any biochemistry textbook, it’s called the carnitine. Shuttle right. Every medical doctor, doctorate level person would studied this at a graduate level. I studied as well now in the textbook of I think that guidance Physiology, but there’s another textbook of biochemistry that’s common at the graduate level. You know what the rate limiting amino acids to make carnitine are. It’s methionine and lysine and so really important.

Dr. Justin Marchegiani: Guess what some of the rate limiting amino acids are in a vegetarian diet.

Evan Brand:  Oh yeah, well.

Dr. Justin Marchegiani: Medallion Leisinger actually very deficient in vegetarian diets, and so this whole process of a carnitine shuttle here that helps bring carnitine converts it into acetyl Co A. So then the actual it can get inside the mitochondria. And run through the citric acid cycle again. That’s the same thing as Krebs Cycle. They have multiple names. In medicine for the same thing, it’s just meant to confuse people. So citric acid cycle or the Krebs cycle.  This is how we get fat inside the mitochondria is via carnitine. So very important, right so if we zoom out. Here, we have energy out here, fat. We get it inside via the carnitine shuttle. Super important there and then you see carbs. Right glucose, other sugars. We go pyruvate to lactate and we need guess what B vitamin? So if we’re putting in lots and lots of refined processed sugar and we’re insulin resistant, we can actually deplete B vitamins. And we can actually deplete a lot of magnesium and other nutrients downstream. So, this is really important. Too much carbs, too much sugar, especially if you’re insulin resistance and you’re putting on weight due to too much carbs. That’s going to be a problem, and you’re going to deplete nutrients now. Then we have proteins, amino acids. These all get converted downstream. We also need B itamin to support that now the difference is if you’re eating high quality protein. Guess what? You’re getting good quality B vitamins in that. Protein if you’re doing a lot of refined processed sugar, guess what? You’re not getting vitamins and nutrients with it. So carbohydrates, it’s possible to eat a lot of empty carbs that are actually going to deplete your nutrient levels. Protein not as much if it’s grass fed and organic right now, really, you’re taking all these nutrients, fats, carbs and proteins. You’re converting them into acetyl Co A. OK, you’re converting it to acetyl Co A and again we spit off beta-hydroxybutyrate what’s that? That’s a ketone now this is important. If we keep our carbs in check we can use ketones for fuel, so this is a really important fuel source or people that are going to be lower carb because we’re going to be more keto adapted. We’re going to be able to use that and then you can see here that acetyl Co A. Runs around the Krebs cycle. Twice we go 2 turns. Guess what, we need cysteine amino acid iron really important. So if you’re a female you have heavy bleeding your estrogen dominant you heavy bleeding that’s in effect energy magnesium manganese B vitamins lipoic acid magnesium B vitamins B vitamins tyrosine phenylalanine aspartate, glycine, histidine, arginine, proline. Glycine, valine methionine, right? These are all amino acids over here. So, we need amino acids to run these systems. We need B vitamins. We need magnesium and then of course, once we pump these things around, here’s our NADH and then our FADH should be there somewhere as well. So here NADH, it may not. They may just be oversimplifying it not showing it. But we have NADH here. We should have an FADH2 coming in. This all goes right into. Guess what? This is the electron transport chain and base. Yeah, fatty acid oxidation right there, right? This is now now hydroxymethyl Glutarate. This is Co Q10. This is where Co Q10 comes in and this is where it runs through the electron transport chain and burning fat for fuel and we generate our 36 to 38 ATP from all these three sources 1-2 and three and so that’s what’s happening in your mitochondria. So just to kind of highlight macro nutrients, fats, protein, carbs, very important two, don’t junk it up with all the toxins that you mentioned. And then of course, making sure we. Can breakdown protein. Make sure we’re getting enough iron making. Sure, we’re not. Anemic right? All of those things kind of flow into allowing all these pathways to to work optimally.

Evan Brand: That’s amazing, I love the breakdown to that. The visual super helpful. So just to clarify a little bit. So for women out there, you’re saying that if having heavy ministration, they have low iron. It’s not just the the low iron that we assume is creating like a low oxygenation, you’re you’re showing here. The low iron is literally creating a mitochondrial deficit.

Dr. Justin Marchegiani: Correct. You’re not getting the oxygen in right? If we go back to here, right? Mitochondria, what do we need to get into the mitochondria? Oxygen, what’s one of the big carrying capacities for oxygen in the body? Hemoglobin and then iron affects hemoglobin in red blood cells, right? Hemoglobin is part of the red blood cell carrying capacity and we need the iron to really keep the hemoglobin levels up so we can carry enough oxygen.

Evan Brand: Wow, so there’s why you’re tired.

Dr. Justin Marchegiani: Could be. Yet, one and then of course all of the other nutrients play a role. Not enough of the amino acids. The only issue with this graph, any biochemists that are looking on? I think the only thing that’s missing is really the FADH2, so it should. So, all these things, they’re just reducing compounds. Really, the whole goal of this Kreb cycle to run is just grabbing hydrogens. And then once we grab these hydrogens, Uhm, these things get cleaved off, and then it generates ATP. What’s happening there? And all these things like hydroxymethyl iterate. These are right. These are all driven through Co, Q10, right? We need Co Q10 to make that happen.

Evan Brand: Now for people like supplementing ketones, if you go back up to the top there, you can basically kind of inject your own spark plug into the cycle, I guess right? If you’re taking exogenous ketones, what is that doing in relationship to this whole cycle?

Dr. Justin Marchegiani: It’s giving you more beta hydroxybutyrate. The problem is your body is going to primarily want to use that when insulin levels are lower, so you have to keep your insulin levels and check. If not, you’re not setting your Physiology up to want to burn that. If you’re probably, gonna pee it out more like more than likely versus burn it. Cause typically, your body has an enzyme called hormone sensitive light pace where it wants to break down fat and convert more of these ketones. Hormone-sensitive light base is inverse with insulin. So hire your hormone-sensitive light pace is you need lower insulin to make that happen.

Evan Brand: So the lady who eats the donut and then goes to the store and buys her exogenous ketones, she’s wasting her.

Dr. Justin Marchegiani: Probably not as good. There may be some mild benefits that you get cognitively just ’cause your brain has some additional fuel to run on. If people brains are insulin resistant, they may have a lot of sugar from that doughnut, but the cells in their brain maybe so numb. To it that they may not be able to access it so some ketones could be helpful, but in the end, you want to fix the insulin resistance if you’re going to do it. Try doing both. Don’t just do the ketones. Try to do both that you can.

Evan Brand: And you can make your own ketones too. For free.

Dr. Justin Marchegiani: Yeah, yeah, that’s how you’re doing that you keep in your insulin in check. And you’re going to start. Making your own. 100%.

Evan Brand: Yeah, cool.

Dr. Justin Marchegiani: Cool, that was awesome. Very cool guys. I hope you guys enjoyed today’s podcast. We’re trying to be a little bit more visual; you know. Go into some hard hard science Y stuff, but you know just kind of zoom out. Like what’s the take home right? The take home is don’t put junkie toxins and that screw up your mitochondria right? Antibiotics, I mean antibiotics? You know if if you have an acute infection that’s not resolving, you know you gotta do what you gotta do, right? You have an acute pneumonia. You gotta do what you gotta do. Talk to your doctor about it. Just don’t go to antibiotics all the time as your first line defense. Try to do some. More natural things to fix it #2 you know, try to be aware of mold in your environment. Make sure you’re not. Getting exposed to pesticides. Chemicals heavy metals. Make sure you’re doing your best to hydrate right. We need water to make this whole thing work too. I would say after that make sure you have your macronutrient style, then good quality protein fats and carbohydrates. Organic sources dial in your carbs so you’re not insulin resistant and make sure your inflammation is good. Inflammation helps with oxygenation and blood flow. Then after that we can look at using supplemental nutrients in my line and Evans line we have mito supports products mine is mito synergy. Evans is my toe. Boots will put links down below. Those products have a lot of these nutrients. It’s going to have the ribose to creatine the carnitine, the B vitamin. Since it’s going to have the Co Q10, it’s going to have actually Kreb cycle intermediary compounds like fumarate malate, succinate. All those different nutrients or run those pathways better. Of course, that all sits on top of a solid diet. Don’t take supplements if you’re going to eat crap, eat really great and then say OK now I’m going to work on enhancing it. And again, we can run testing on organic. Message to look at some of these intermediary nutrients, like citrate to connotate succinate bloomer, a mallet we can actually test them, which is pretty cool.

Evan Brand: Yeah, the testing is the best part because you you know if you actually need it. I can tell you the average person has mitochondrial problem, so in general, could you just take this? I kind of call it a multi for the mitochondria. Could you just take that test? You know like a guess and check you could, but we like to see the data and obviously my biggest thing is looking for mold colonization. Candida overgrowth clostridia. Some of these gut infections and how that affects your brain chemistry too. So when you do the oh, you really are getting the best bang for your buck in terms of testing. Like if you could only do one test out there, I think the oh it would. Probably be the number one most.

Dr. Justin Marchegiani: Important 110%. Anything else you want to say?

Evan Brand: If people need help, they can reach out to you worldwide or me worldwide. Doctor J at justinhealthcom me Evan at evanbrand.com and we would love to chat with you about your symptoms, your goals and we’ll tell you for your good fit for care, so please feel free to reach out. Look forward to helping you.

Dr. Justin Marchegiani: Foot and get adjusted. Help calm here and then you guys have any questions, comments or concerns. Put him down below. Let us know. Kind of what you’re doing. What’s working that really helps us out as well. Very cool. Alright guys, well you guys have a phenomenal day here and we’ll. Be in touch. Take care of y’all.

Evan Brand: Sounds good.

Dr. Justin Marchegiani: Alright Bye bye.


References:

https://justinhealth.com/

https://www.evanbrand.com/

Audio Podcast:

https://justinhealth.libsyn.com/the-gut-lung-connection-your-gut-health-can-affect-your-breathing-podcast-348

Recommended products:

Mito Synergy

Mito Boost

Deluxe Mold Test Kit

GPL Mycotox

Genova Organix Comprehensive Profile

Genova NutrEval FMV

 

How Your Iron Levels Are Negatively Affecting Your Health | Podcast #346

Iron is a mineral part of hemoglobin, the protein in red blood cells that transports oxygen from the lungs and throughout the body.

Dr. J and Evan also discuss identifying underlying issues to deal with them effectively. You could be having digestive problems, menstruating for women, or you’re not eating the right foods to source iron or adequately absorb it. So if your body doesn’t have enough iron, it won’t get enough oxygen, and your cells (powered by oxygen) won’t function efficiently. Suppose you’re experiencing symptoms of iron deficiency.

In that case, Dr. J and Evan suggest consuming vitamin C to help increase iron absorption, eat iron-rich plant foods, and have yourself tested to have comprehensive test results and fix your health issues.

 

In this episode, we cover:

1:19:       What is iron deficiency and how to test it?

5:36:      Iron-rich food template

10:04:    Other issues to consider when dealing with iron deficiency

17:09:    Iron deficiency in men

 

Dr. Justin Marchegiani: And we are are live! It’s Dr. J here in the house with Evan Brand. Today we’re going to talk about about iron levels and how can they negatively impact your health. Of course, we have two sides of the same coin here. We have high iron and low iron. And then, high irons going to be a bigger issue, right? Men don’t menstruate and women potentially, low iron is going to be a bigger issue because women menstruate every month at cycling; it’s a cycling age. Menopausal women, when their cycle tends to cease, then there could be more issues there. But out of the gates, women iron is going to be an issue. Most of the time if it’s hormonal issues and men’s going to be the opposite. We’re going to dive in and give you guys a crush course on both sides of the fence. Evan, how are you doing today, man?

Evan Brand: Doing well! Let’s jump right in. So looking at blood work. If you’re looking at a female, you and I test ferritin which we find conventional medical doctors rarely test ferritin. Ferritin being the iron storage protein and I did a whole video on Youtube. Those are my most popular videos ever on low ferritin and hair loss. We’ve seen how if your ferritin is let’s say 20, that’s far too low. You’re going to experience maybe some shortness of breath, major hair loss. If we can get the ferritine to 70, 80, or 90, women feel much better. Their hair stops falling out and they can catch their breath. So do you mind like, teasing a part when you’re looking at these labs, like total iron versus a ferritin. If you see a female with low total iron, are you really prioritizing that or are you after ferritin or are you going after both? How do you approach it?

Dr. Justin Marchegiani: Well the first thing that we look at with iron, we have to see how low it is.Okay? There’s func- I consider functionally low levels of iron. And um, and there could be um, you know more, I just say more acute levels of iron that are are more low. Right? We could have functional imbalances versus the more anemic that conventional medical doctors would say you’re low in iron. We have both side of the fence, right? We have the functional issues, and we have the pathological issues. So the first thing we look at is going to be a CBC, right? On the CBC we’re going to look at red blood cells, hemoglobin, and hematocrit. If we see those start to get low, especially red blood cells you’re going below 4, hemoglobin into the 11, hematocrit below 30s, we have problems. Danger will rob– the red blood cell size is dropping which is the hallmark of low iron. Because we need iron that attaches to hemoglobin that help us carry oxygen. So we have hypochromic microcytic anemia. These are going to be smaller red blood cells, right? Smaller blood cells are going to be on the iron side. On the B12 side, it’s actually the opposite; they’re actually bigger. It’s called megaloblastic anemia. They’re actually too big. The red blood cells are opposite. We think of humans, we start off as babies and as we get bigger right? Red blood cells, they start off bigger and they actually get smaller as they get older. And so, B12 is needed to mature. Red blood cells, and so if we don’t have enough B12, you’re stock in this more immature state which is bigger, and you don’t have enough B12 than you can’t get smaller. Now with the iron, it’s actually the opposite. You actually get too small when the iron is too low. And of course, you can’t carry oxygen which is really important because aerobic metabolism which is how we mostly generate energy requires oxygen. And so that’s like, you know partly the kreb cycle, the electron transport chain, and all that stuff um, requires oxygen. So on that front, just kind of out of the gates there, we’re looking at um, iron from that perspective. Red blood cells, CBC, hemoglobin, and then we can dive deeper into an actual iron panel. And that’s we’re going to look at serum iron, that’s going to look at iron in the blood. Then we can look at ferritin. It’d going to look at our storage form of iron. So iron serum and ferritin are two different things. So think of, You’re driving a car, right? You have your check engine,Or should say you have your gas gate, right, for your fuel, right. Your fuel gauge that’s kind of your ferritin. Are you on full are you an empty? The iron serum, that’s the fuel that’s in the– ready to be, ready to be um, combusted to generate energy. Think of iron serum, that’s what’s in the engine, that’s what’s in the blood right away. Ferritin is going to be what’s in the gas tank. So you know of course If you see iron low on the serum side, you wanna look deeper but it’s not beol or endol. You have to look deeper on what’s  in the gas tank. That’s where iron serum um, sorry, that’s where ferritin will be more helpful and other markers like Iron saturation can be helpful too. Because that tells you how saturated the cells are, and also things like binding proteins. Um those tend to do the opposite, those tend to go up When iron goes um, goes down. So think about it, thinking about iron binding proteins is like fingers right. The more or hands right, the more hungry you are the more hands reaching out to grab stuff right. And so your body creates this protein and will try to reach out and grab these extra irons to create more binding proteins when iron is lower. It’s trying to get that much iron into the cells as possible. Does that make sense out of the gates?

Evan Brand: Yeah it’s a great breakdown. The analogy is super helpful. Because you know some of the blood chemistry training that you and I have looked at, some of the doctors, they will talk about the importance of ferritin. But that visualization of the gas tank Makes a whole lot of sense because you have doctors, if they do recognize low iron, they’ll treat that. But then if you see low ferritin, The woman still doesn’t have the results she’s looking for with regards to hair loss and catching her breath and all that. So once you get the ferritin levels up, Which typically I go for lactoferrin. What are you doing in terms of trying to get the ferritin back up? I know optimizing the gut is some of it, we can talk about that. But what about just straight supplements?

Dr. Justin Marchegiani: So first thing is you may see higher levels of iron in women that may have low iron. So you have to look at all the markers that I’ve mentioned because if they are inflamed, iron is also a reactive oxygen species right? Think of it as like It’s kind of inflammable if you will and so, and so when you are in inflamed because of poor food, poor diet issues, or toxicity issues, you may have higher levels of iron ferritin because of inflammation. If you’re really inflamed i always I like to make sure that it calm the inflammation down a little bit first before throw iron in there, it’s like gasoline in the fire. So you really want to make sure you know if iron’s really high or looks really high and then we see some inflammation markers like CRP also high, we see a lot of symptoms, right? Brain fog, joint pain, energy issues; Maybe we wait a little bit before we jump on that iron train right away. Maybe we just chew some iron rich foods, you know on the animal side and work on getting the inflammation down. So it depends upon where they’re at.

Evan Brand: That’s smart, let me comment on that real quick. That’s really smart and really wise to say, because people would just jump on that iron train right? Those doctors who prescribe iron probably low-quality form which is going create constipation and other problems. And if they are already having high iron Information due to some toxicity, that makes them worse. I had one high iron when I was first exposed to mold. I actually look back on some of my olde levels. My ferritin was high, my iron was high. And i did some pretty high potent seed turmeric extract, and i was able to get the iron back down. And i’m sure the blood donations may have helped too. But it was interesting to see that on paper, how my exposure to toxicity cranked that up a little bit.

Dr. Justin Marchegiani: Exactly and then There is a marker called Seruplasman Which is a marker for copper So sometimes copper and also affect iron as well. Again i’m not too worried of copper If you’re like Paleo and you’re eating high quality organic meat and high quality animal products.   close your typically going to see the zinc and iron products cause you also have copper in there. So i don’t typically get worried about copper unless we’re really I don’t know, eating a lot of plant-based products. And we’re kind of deficient and some of those minerals, and so eating good quality animal products may not be that big of a deal. And also it’s good to look at if we’re doing iron, If someone is vegan or vegetarian, you know there’s different kinds of iron that we use right? So in my line, i have a product called vegan supreme which is an iron disglycente which is found in the glycine, which is good. It it’s better like conventional medicine which is ferrous sulfate which will be more constipating, leaving the stool black-er and darker. Glycinate  tend to be pretty well absorbed so i like that in the glycine Which is same kind of amino acid and collagen and bone broth so i like that. Also, i would say depending on vegan vegetarian you may want to add some grass fed liver. Something like that that’s going to have some other nutrients like B12, vitamin A in there as well. Just depends upon how good or bad someone’s diet is too, if they can eat animal products. And so…

Evan Brand: How about lactoferrin? Do you use lactoferrin?

Dr. Justin Marchegiani: I mean lactoferrin it’s like it’s like a protein right? It’s gonna also… Yeah, it’s like a milk protein like it increases iron levels, kind of vitamin C in a senseWhere it increases that binding in absorption of iron, is that correct?

Evan Brand: Yeah, yeah. I’ve seen like a couple of iron lactoferrin combos that we’ve used. Man, it’s like rocketfield to get women back up really quickly.

Dr. Justin Marchegiani: Yeah for me i don’t typically use lactoferrin in general. I’ll do my iron supreme which is the bisglycinate, And then i’ll throw in some potential iron granular Is there a not eating enough animal products (Evan: like a liver) Yeah, like a liver glandular and a little bit vitamin C on top of that. But um, don’t you know, I see a lot of guys out there. I see people say “Don’t eat vitamin c, it’s going to increase your iron.” No, if you’re a guy, eat vitamin C it’s not a problem. It’s in every leafy green vegetable, every high quality fruit that’s out there, it’s too Important. Guys the solution to iron is just give blood. Get a comprehensive blood test once or twice a year. Maybe give blood once a year um, twice a year depending on how many blood tests you get, just give blood is the solution. Don’t avoid nutrient dense food that have vitamin c that would increase your iron. Just give blood and do some testing. Keep it simple.

Evan Brand: Yeah. That’s the fun part. When you do comprehensive panels like we’re doing. I just donated a blood, got blood work this morning. I gave a lot of tubes. It was probably not much as a donation, it wasn’t a pint but for me, it was a good slow drip out of my system If i’m running some blood panels throughout the year. And you get data. You get data out of it too.

Dr. Justin Marchegiani: I think it’s fun for sure So we talk about you know how to assess these are patterns right? We have our general cbc, we have Iron panel that will include Iron serum, ferritin, Iron saturation um, TIBC, UIBC, which are your similar binding proteins. You can also look up reticulocytes for baby red blood cells you’re losing blood. You’re gonna see a lot more red blood cells because the babies are being formed to kind of filling the gap of the older adult cells that were losing it; it there’s an ulcer or some kind of tummy bleed, IB you know, Irritable bowel disease kind of bleed in the intestines or colon or wherever. So that’s helpful to look at. And in general, you know, if you’re vegan, vegetarian, and you have a history of not getting iron in your body, you gotta fix that. That’s whole different podcast conversation about animal products. We’ll, you guys can go back to our channel, search for that, we had conversations, just on those topics. The second issue for women Is just to get rid of the hormonal Imbalances that are causing you to bleed too much. So if you are bleeding four more tampons, 4-2 days or more, probably just menstruating too much, you know classic cases of hemorrhagic if you will. And there’s probably a lot of estrogen dominance, way higher estrogen, lower levels of progesterone. Maybe progesterone is falling out soon in the cycle and some of the things are diving just excess bleeding and that’s possible too, and you gotta get to the root cause of why that is. Estrogen dominance usually some adrenal stress that affects some underlying issue that is causing that. And of course if you have a lot of digestive inflammation, whether in the stomach area or intestines, or lack of stomach acid, or enzyme you may not be able to break down the high-quality animal products that you’re consuming  that could also create a bottleneck of absorption.

Evan Brand: Yeah when somebody here’s that, they might not realize how big of an impact that could be, right? When somebody here’s what you’re saying. It’s like “oh this gut Ingestion, digestion blah blah blah” But we’ve seen it on paper and clinically Where you have women that are eating paleo, doing breastfed meet, doing a great job with diet, and they’re still very low. Some of it like you said high you know, the excess menstruation but, i’ll tell you personally i’ve seen big changes with my wife’s energy levels after clearing her gut infections out. And we knew that she was having malabsorption. So, and so I mean when your 40 50 or 60 and beyond, you are making Left stomach acid due to age even if you’re eating that grass fed steak, and that liver capsule, who knows how much you’re getting from that. So to me, i think enzymes will be part of a good Iron supporting protocol because you know, people will say you are what you eat. But really, you are what you digest from what you eat. So i think This is a good point to bring up enzymes and acids to make sure that if you have H.Pylori Infection that could be something to address, that will be driving the low iron. Is that a safe statement to say? Is h pylori that big of a smoking gun, that it could drive blow iron due to the malabsorption?

Dr. Justin Marchegiani: Yeah, i mean there’s always you know. There’s always going to be different degrees of how that infection is causing a stress in your body. If it’s there, it’s chronic, it’s creating a lot of  inflammation, digestive wise enzymes have dropped significantly. That may impair your ability to absorb usually there is going to be symptoms that will tell you the severity you know, just things like not having a good bowel movement, having a lot of bloating, or  gassing, or flatulence, and gut inflammation, those are pretty good signs there’s stress going on there. Um, looking at your stools, how formed do they look, are you regular, are there undigested stool pieces in your stool? Those are all pretty good ideas that you’re on a bad track. So it’s good to look at that. Of course if you have chronic iron, and you’re fixing menstruation issues, you’re eating meat, you’re adding in Digestive support that’s all great. You probably want to look deeper and get your got tested and see if there are other bugs in your gut like SIBO, or just general dysbiosis, or parasites or h.pylori, or other issues that could be in place. You gotta look at all of it.

Evan Brand: Yeah. And you mention the inflammation I mean. That could be exposure, that could be the diet, it’s simple. It sound simple but It’s still worth mentioning. We still have so many women that are going to the starbucks drive-thru and getting a pastry, a bagel or a muffin, or whenever, and they have their coffee and that’s it. That’s it for their breakfast and they wonder why they are exhausted. I mean nutrient density is just foundational.

Dr. Justin Marchegiani: Yeah, nutrient density is really important and um, to really have good nutrient density You have to be eating some level of animal products. You’re just not going to get same level of nutrient density from an amino acids standpoint. You’re not going to get the iron, the b12. It’s harder to get the fat soluble vitamin A, I mean you can get some from b12, I mean some from beta-carotene but, you won’t get enough. And if you have insulin resistance, you won’t convert b12, you won’t convert beta-carotene well. You also won’t convert a lot of your ALA-based omega 3. It’s like flax and Chia. You won’t convert that to your longer chain EPA and Your DHEA fats which are good for inflammation in your brain. There’s a lot of precursor things that We just assume like “Oh, we’re getting iron from spinach. I’m going to convert that non-heme iron to non-heme based iron right.” No, I’m getting enough bioflavonoids In my vegetables that are vitamin A right? Well, no. That’s beta-carotene you may not convert that. Or same thing with um, i’m trying to think here what other analogies that you can do. So You have the plant-based iron, you have beta-carotene stuff, you have the vitamin, I’m trying to thank you for what else um, zinc and a lot of your minerals may be tied up in antinutrient plants. You might think you’re getting a lot of this vitamins and minerals but you may be having them tied up with a lot of antinutrients – the lectins, fitates, the mineral blockers, the trypsin inhibitors,  and so you might think you’re getting some of these things on the nutrient label but, there might be some absorptions because of this nutrient blockers. Proteolytic enzyme blockers.

Evan Brand: That’s a good point. So far vegetarians-vegans listening, if you could get them on liver capsules, you’d say get them on some pastured liver would be a great option. If their opposed to that even, I mean what do you do? I’ve seen women from paper suffered for years, and I honestly just used the labs as justification to push them harder into something like liver capsules if they just absolutely don’t wanna do the meat.

Dr. Justin Marchegiani: Yeah liver capsules or going to be ideal That’s where i put my iron supreme which is a ferrous-glycinate, and add in some amino acids like collagen and some kind of free form amino acid to get the protein of without antinutrients and carbs in there as well ‘cause a lot of vegan vegetarian proteins, they’re just very carb heavy right? Rice and beans, quinoa, they’re just you know, they’re just 60, 80% carbohydrate for the protein to get in. So it’s hard if you need to keep your carbs down for insulin, For inflammation or fat burning means it’s hard to do that If you try to stick to a vegan vegetarian diet I need you can do that if you’re adding some protein or rice protein but then, you’re heavily reliant on processed food for most of your protein. And that’s not great so we don’t want to have things to be so processed, like we have to be overly reliant. It probably tells us that your diet needs to be tweaked and adjusted if you’re heavily reliant on processed food to get your nutrients up.

Evan Brand: Yep. Well said. So men definitely get your iron tested too I mean females are probably gonna be more symptomatic than men, meaning, the fatigue, the hair loss-that kind of thing with the low iron. But man, you can have symptoms from that. I will tell you i’ve had, when i went to donate blood, I found my hemoglobin was very high. They’ll cut you off by 20 It’s above 20. You have to get a prescription to donate blood, and then back at the therapeutic blood donation but I would like a 19.6. I felt like I was going to be mentally foggy, mentally cloudy and certainly more brain fog, and I would say my energy levels were a little bit less. And I ask some of the donation people like, “What would you think i will experience based on this level of hemoglobin?” They were like “Oh, man you’re high.” And I go like, “Ok, what should I feel like?” And they actually said exactly what I felt. They thought you would feel cloudy and then I would remember this feeling when donating a pint, boom! It was like this release. Like literally almost like an energy drink after I got that excess iron out. So i tell you, it’s very very therapeutic.

Dr. Justin Marchegiani: Yeah, and again iron is going to cause oxidative stress. So if you’re a male, and you are over accumulating iron you know, give blood. Get some therapeutic functional tests doneSo you’re actually losing blood via the testing means. And make sure that you know, taking in a really good high antioxidants you know, through organic vegetables, maybe low sugar fruit. Because at least the antioxidants that you’re getting in will help at least buffer the oxidative stress from the iron right? So at least you want to make sure Antioxidant levels from fruits and vegetables Are dialed in and we’re getting healthy. You know antioxidants and maybe through curcumin or other high quality nutrients that help buffer some of that, help offset some of it.

Even Brand: Yeah yeah cool well If you want to get tested uh, Dr Justin able to run blood work, I’m able to run blood work, we do it around the world which is pretty cool; I guess, technically blood work that we do In the United States. Little tricky internationally for blood work (Dr. J: It’s still better but it’s harder), yeah it is harder but for the other, for the functional testing which you can do functional blood testing and that’s what we do. Our panels are much more comprehensive than what you’re going to get down the street from your doctor. So if you need help you can you can reach out And just please let us know If you have trouble a lot of time people are begging their physicians to run a comprehensive fire oide panel, run the antibody, to run the ferritin, you shouldn’t have to beg someone to get these markers done. This is very simple we can literally get your requisition form the same day. You go straight to the lab, you don’t have to beg somebody to run it. So if you need help, please reach out to Dr. J justinhealth.com or me Evan Brand evanbrand.com. We would love to help you with this and other related things too. Whether it’s gut Infections we need to look for Four sources of inflammation driving this. There’s probably some root cause It’s not just magically going to happen like this. There’s probably a couple others– you know, It’s an entangled spider web If you will. So we’re going to kind of tease that. We love doing that; it’s very rewarding when you see a woman who is buying all these hair loss control shampoos and these special products and their get sucked in into by their hair salon, and they just simply needed to optimize their ferritin levels.

Dr. Justin Marchegiani: Yeah if your iron levels are low, It can impact your thyroid. If your iron levels are low, it can impact your adrenals because you need high quality you need to carry oxygen to be able to um, you have aerobic metabolism, you need to carry oxygen to have good thyroid function. If you don’t have good thyroid hormones Important for stimulating hair to grow, and of course if you’re not breaking down your protein, and or iron you’re not going to be absorbing all the proteins and facts to build up your hair to make our hair healthy. So all those things can play a major role. So guys get blood, get some testing done. Women, make sure people in general, women especially make sure you’re eating high quality animal products or at least something right. Maybe eat some egg yolk. Maybe eat some liver capsules. Just try to do something that ‘s going to meet the middle of it. And then outside of that, get tested as well, and if you’re female and you’re bleeding, you gotta look at the estrogen dominance, and you gotta look at the progesterone. Conventional medicine is just going to throw birth control pills at you and that’s not going to fix the issue. It’s actually going to compound and make the problem worse because estrogen pills can lower B vitamins-B-12, and Folate, and calcium. It can lower other nutrients and it actually makes your estrogen dominance worse right. It’s giving you more estrogen; giving you a consistent level which is better you know, having the up and down but, it’s not fixing all of the hormonal imbalances; Just covering things up. So If you want to get to the root cause, reach out to Evan Brand evanbrand.com or myself Dr. J at justinhealth.com, we’re here to help.

Evan Brand: Amen! You did a great job. I think we killed it.

Dr. Justin Marchegiani: Alright. Excellent. By the way, what are my ranges, uh, ferritin 30-40 enough for women, uhm, men you know 60-80sh i think pretty good for that, iron saturation 25 and up. And i think it’s a pretty good kind of starting point there. Maybe binding proteins below 300 that’s a pretty good thing out of the gates.

Evan Brand: Yeah, i had a woman with a ferritin level of 6 She can hardly get up a flight of stairs because she was so short out of breath, her hair was falling out In clumps, her husband is mad at her because she was clogging the shower all the time. Once we got her ferritin back up to the 50s, her hair stopped falling out. She felt so much better. She can run of the stair without passing out. I mean, it was just incredible so don’t underestimate this. I know you guys listen to us on a regular basis. Even some clients they tell us they listen to us while going to sleep. Don’t sleep on this issue. This is something you really got to address.

Dr. Justin Marchegiani: Yeah, it’s an important issue for sure. And for guys, with low iron yeah, vegetarian-vegan, make sure you’re not doing that. Vegetarian vegan, look at the gut. You are probably not absorbing or digesting or breaking It down. Get the gut, look deeper. All right Evan, have a phenomenal day, man! Great chatting with you!

Evan Brand: Take care now you too.


References:

https://justinhealth.com/

https://www.evanbrand.com/

Audio Podcast:

https://justinhealth.libsyn.com/how-your-iron-levels-are-negatively-affecting-your-health-podcast-346

Recommended products:

Iron Supreme

Genova NutrEval FMV

Comprehensive Bio-Screen Blood Test

 

The Top 5 Anti-Aging Techniques to Age Gracefully | Podcast #342

Hey guys! In this video, Dr. J and Evan discuss the factors that affect the aging process. They are more straightforward—and less invasive—ways to look younger than mainstream or conventional ways. Dr. J suggests incorporating a few of these habits into your daily routine that won’t just leave you fresh-looking and it’ll boost your overall energy. Watch the video to learn how. Of all the places on your body, your gut is silently receiving different food that can cause the entire aging process. That includes standard precautions such as maintaining a well-balanced diet rich in good fats. But there are also quite a few ways that you may be aging your body without knowing it.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

3:00:   Inflammation

7:21:   Insulin Resistance and blood glucose

16:59:  Sleep in the aging process

27:46:  Fasting Techniques

30:26:  Importance of movement and exercise

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Youtube-icon

Dr. Justin Marchegiani: And we are Live! It’s Dr. J here in the house with Evan Brand. Today we’re gonna be chatting about natural strategies to help detoxify round ups or glyphosate. Really excited to be chatting with Evan today. Evan, how are you doing today man?

Evan Brand: Doing really well! This is a super important topic.You sea many many lawsuit around the country happen and bayer who bought monsato. They’re really trying to get out of it. I’ve seen several, I’m no law expert but I’ve seen several stories how basically they’re trying to just, throw one lump sum out there for all the cases, as there are thousand and thousand of cases coming at them, because of different cancers like non-hodgkin’s lymphoma that people are claiming that has been linked to their glyphosate exposure. Whether it was like the school grounds worker who was a famous story  or other people. They’re really coming at them hard and they’re really really trying to weasel this way out of it and then I saw news just uh, last week actually, that glyphosate is actually going to be phased. I don’t know if you saw this but it said it’s going to be phased out by 2023. So I sent this new article over to Stephanie Synep who I’ve interviewed several times about glyphosate, and she goes “yeah, I saw this. They’re probably just going to come out with another slightly different molecule that’s just as toxic”. So she didn’t think it was that exciting news.

Dr. Justin Marchegiani: Interesting! Yeah, I mean, I wouldn’t be surprised. It’s kind of like a lot of the medication they have many me’s for it right. Something they can re-patent, um, almost the same molecular structure so they know it’s going to work based on the previous medication or compound but they don’t really have to do too much RND on it because, it’s so close to where it was. So yeah, I get that maybe, probably, the same toxicity profile too. So that makes sense, hopefully that’s not going to be the case but either way, we have a lot of toxins in our environment and roundup’s just one that we have a lot of other pesticides, herbicides, or genocides that are out there. Obviously, a lot of potential chemicals in the water, air, and so roundup or we can kind of put roundup of pesticides – all in the same category, I think that’s pretty fair . So you know first thing is, try to mitigate the use of them on your property, I mean, I use a little bit of pesticides in a spot treating, man. Are we trying to avoid anything blanketed or anything just, you know, blanketed across the board, and you know, we don’t really play out in the grass that much, I mean so if your kids are rolling around out in the grass definitely pay extra money and have those weeds picked up by hand. I think that’s a better way to do it but every now and then, there may be a necessity to spot treat stuff but do your best to avoid that especially if your kids are playing near glass like that, or just have a grass in your yard that you know, this is the play area this where the kids go. We put a nice little rock pit in our backyard just because we know that the rock pit’s going to be perfect right? Put some like, soft help you know, small pebbles in there, um, that are you, um, still fun to play in and they have a digger pit and all that so just try to do your best if you have kids that are young that are playing; mitigate any playing on areas that have any pesticides at all; try to mitigate the use of them, 100 percent and try to have safe, safe spaces in your yard that, you know are perfectly clean.

Evan Brand: There is an alternative to roundup. I’m trying to figure out what it was the moms across America did and article on it-I’m trying to fin it here-it was like a non-toxic weed control. I don’t care about weeds; my grass looks cool and it’s got clover. We’ve got many other different species of plants besides just grass. I mean, I think it’s a myth and it’s dumb you have all these neighborhoods where they think you got to have the grass looking perfect, and grass is just like another version of monoculture. It’s like if you go and walk through my yard, you’re going to see so many different types of plants so I just don’t care. I think people have been brainwashed by the mainstream industry. Even our neighbor we’ve seen you know just out in flip-flops, spraying the glyphosate on their weeds. It’s like who said dandelions are bad? Like, that’s the first food for bee so for me, I’d rather see the field full of dandelions. I guess it’s personal preference but I kind of like it.

Dr. Justin Marchegiani: Yeah. It just depends. You know, the biggest problem with weeds in relationship to grass as they grow like, three times the speed, so if you haven’t cut your lawn for a week your grass in this long and your weeds are this long, right? So you missed the nice homogeneous, kind of, clean lawn. I’m a big long guy, I like a nice, clean, homogeneous lawn so I’ll walk out there, you know, halfway through the week if I see any weeds popping up; it’s easy because they grow twice the speed, it’s grass, and I’ll just go and take five minutes, and I’ll just pull my hand. You know, I’m like I  like a really nice pretty front lawn. So I’ll go there spend 5-10 minutes a week walking around, pulling by hand, just to mitigate the chemical usage but. First thing is, decrease the chemical usage, decrease the chemical dependency out of the gates. I guess that’s the easiest first step.

Evan Brand: So here’s one. So it’s called, there’s one called Dr. Kirchner natural grass and weed killer. I’m gonna to try to look it up, see what the ingredients. There’s another one, another competitor to it called, Green Gobler. And that’s a 20% vinegar weeding grass killer. And this thing’s got crazy high reviews of it. This Dr. Kirchner k-I-r-c-h-n-e-r natural weed killer . This is just, so it’s four percent sodium chloride, interesting. And they say this ocean water-based product is made for non-selective control of broad-leaf weeds and wheat grasses results in hours. So there you go, I mean it sounds like they’re just using like, concentrated ocean water, they’ve got thousands of five-star reviews on people, people on Amazon are posting their reviews of them in their garden after spraying this stuff and it literally kills it all. This lady said here that it’s magical and safe. So there you go!

Dr. Justin Marchegiani: So we’ll have to put some links down below. So you have what, so what are those two products? Those ones that was an apple cider vinegar-based, what else?

Evan Brand: Yeah, and then you got this other one that’s salt water, it’s literally like, four percent ocean water concentrate, and then you have another one called, Natural Armor which is a 30 percent vinegar concentrate.

Dr. Justin Marchegiani: Okay.

Evan Brand: My wife even saw one at Target recently. She saw like an organic herbicide. I had a picture of it, I don’t know if I could find it on my phone or not but, she sent me a picture the other day. She said there’s no excuse for people using glyphosate; I said I know, I know, and then she sent me that picture-let me see if I can find it.

Dr. Justin Marchegiani: Good. That’s good. I mean glyphosate, what is does is, it it basically is a chelator, it pulls away all the minerals from the soil, and so it decreases the minerals getting up into the plant which then kill it. And so, if you’re using it even worse on food you’re eating, It’s it’s way worse. Because now you’re destroying the quality of the topsoil, you’re destroying the minerals in that soil, and we know that soil requires minerals so that plant can, um, let’s just say express it you know, express it’s full nutritional potential if you will. So if we have nutritionally deficient soil, like manganese for instance, you know, vegetables are going to have less vitamin C in it, right? So we know the minerals have a major role  and they and the quality of that soil, plays a major role in the kind of nutrientsthat plants will produce. So you’re gonna have less nutrition in soil where there’s a bunch of roundup that’s chelated out a lot of those minerals.

Evan Brand: Yeah. I was gonna say, let’s hit on the mechanism . So that’s definitely a big important one, and then the other one that you and I test for in the gut is, we’re seeing the glyphosates damaging the beneficial bacteria in the gut. And this is happening at even PBB – parts per billion levels. So once you kill off the beneficial bacteria in the gut, now you see the overgrowth of clostridium, and there’s a famous chart-I know you’ve seen it before and hopefully others have seen it. But you could just look it up, type in glyphosate autism chart, and you can see the correlation where glyphosate skyrockets along with autism rates, and I’ve seen many many autistic children and we test their glyphosate levels and they’re always high. So, this is not saying causation, but this is in correlation; and William Shaw, Bill Shaw-he’s a guy at great plains lab that we, that we use for these toxic chemical tests. You know, he wrote a great paper on this. He had a paper published about the mechanism . Essentially, it was like an order of operations. It was the glyphosate, as you mentioned, will cause nutrient deficiencies but then damages good bacteria. Bad bacteria like clostridium overgrowth. Now you’ve got these organic acids that go high which mess up an enzyme that breaks down dopamine, now you’ve got excessive dopamine, now you’ve got brain toxicity and the you damage the mitochondria. So it’s a long, a long route there but, this is directly damaging mitochondria which is certainly linked to chronic fatigue and other issues so, when we’re looking at someone’s picture of health, and we see they’ve got a major overload of pesticides, and they’re fatigued, we’re not gonna say, “Hey! This is you number one smoking gun of fatigue” but, it’s certainly a big peace of the puzzle; and I can tell you personally but also clinically when we use nutrients which we’ll get into to detox these pesticides-we see that energy levels go up; and you mentioned exposure, so also, you got to consider where you live too. So even if you’re having Joe Bob next door spray, that might not be as big of a deal as more agricultural areas which is you know, partially where I am which I don’t like. There’s a corn and soybean around here. This is just part of the country where I, where this happens and there’s papers on even one mile of pesticide drift. So the question is…

Dr. Justin Marchegiani: Far more worried about you because, just the load, you know, if you look at the, just the load coming through.

Evan Brand: Oh, yeah.

Dr. Justin Marchegiani: Uh, and your area is just got to be, you know, orders of magnitude. 10, 100x more than just a general uh, you know, residential person that’s just trying to knock down weeds a little bit.

Evan Brand: Totally. Which, which we’re aware of. We’re working on it and we’ve got, we’ve got an exit, so we’re working on it but, yeah. Luckily, we’ve been doing a lot of things. Are you ready to talk about some of the solutions? Obviously, avoidance, external exposure, trying to stay away from it, watching out for like, playgrounds. You know, a lot of playgrounds, they’re too lazy to pull the weeds so they’re just going to spray it so you’ll see often signs at playgrounds like, “watch out!”, and you can tell that they’ve sprayed on the mulch where the kids are playing, and then you may say, “Well, oh! We’ll just go to a rubber playground”, where you have all those chopped up tires but, those are really toxic too. We mentioned those rubber chemicals on the chemical profile for children too. I had a child, a young child actually, was a client who was diagnosed with a rare type of cancer, and we looked at the levels of 1-3 butadiene and maybe some other chemicals; and these are all from synthetic rubber, and this kid was like a stup, a superstar soccer player. He was playing indoors, like 24/7. This kid was these fake rubber mats and his levels were like a hundred x higher than 95th percentile and that was a known carcinogen so we can’t say the rubber caused it but, man, it was certainly a big smoking gun in this case.

Dr. Justin Marchegiani: What’s the chemical name?

Evan Brand: It’s so, it’s 1-3 butadiene. It’s on the great plains chemical report. It just says using the production. Yeah, just as used in the production of synthetic rubber.

Dr. Justin Marchegiani: Yeah. So it’s definitely possible, right? So, I mean, out of the gates, the first thing is, we look at our food. Right? First this is make sure you food’s organic because you’re going to have major exposure if you’re taking things in, internally. Right? Things on the outside of the world like yeah, if you’re touching it, right? That’s going to be a problem so one try not to use it at your property or if you do you know, like you know, we try to use it more like glyphosate but kind of more natural version in the front yard spot treated. But in the backyard or in the play any area where we know that kids actually play. Like that’s just going to be off-limits. We try to make sure it’s super clean and good there; and then number two is um, you know, air is going to move all this stuff around. So even if you know you yard’s clean, your neighbors may not be clean. So you got to make sure air filtration in your home is dialed in so you can mitigate it potentially being in the home and breathing it in constantly. So air filters in the home, water filer because there’s also the worry about it getting off into the water table, and if we have a well or anything else, very concerning so you want to make sure good quality water filtration and then like I mentioned earlier-organic food and try to mitigate it’s usage around your property, or try to choose natural sources.

Evan Brand: Yeah. I’m glad you mentioned the water too because that’s important. Believe it or not, even glyphosate’s being found in rain water which is crazy. It’s literally raining down glyohosate because it’s evaporating from various farms and agricultural than it’s moving through the wind currents and then getting rained down on people, and you may say, “Oh well, that’s got to be such a trace amount it doesn’t matter. Well that’s the thing, we’re finding that these, these compounds are active against the beneficial bacteria in your gut at these per billion levels. So you really can’t brush it off. People will try to brush it off but, it’s the small levels, and it’s the synergistic effects, right? So you’ve got a little bot of that and then you’ve got it from your diet. Plus you’ve got it from your water supply, plus you’re getting rained on in your organic garden. This adds up overtime and you and I see bacterial overgrowth everyday, all day; and we know that this is certainly linked to the disruption of the gut-these chemicals. So it’s too important to ignore the air filters is a tough one. I asked Stephanie Synep about that I said, “Hey! What is the actual size of glyphosate? I can’t find it. I’m trying to figure out because you’ll see air purifiers talk about a one micron or a three micron filtration, and she said “Oh, no. There’s no way you’ll be able to filter it. It’s too small so that’s what she said bit, I can’t find anything about the size of it. I’ve asked a couple of companies about is and they say, “Oh, yeah. NO problem. Our air filter will take care of it”, and another company said, “Oh, yeah. Our air filter should destroy the molecule” but, I don’t know how you would yest that. You’d have to like, I don’t know; Have somebody spray a bottle of glyphosate into a room and then run the purifier and see what happens but, it’s removed so many other things that it’s a non-negotiable us, and I know you do the same like, air purifier…

Dr. Justin Marchegiani: Yeah. It’s moving a lot. I mean, you know, we like the Austin Air just because they have the 30 pounds of activated charcoal and zeolite, and those binders, you know, would have a positive effects, binding up these things and so it’s definitely going to decrease the load for sure. If it’s blowing through a hepa filter and also  through the 30 pounds of zeolite and activated charcoal. It’s going to have mitigating effects. It’s going to be better off, you know, on when it’s out than, than before, right? So I think it’s still a good thing to have to what degree, um, I don’t know but, in general, it’s good to have, of course the water is a big one. So I try to have all my water that I drink personally-reverse osmosis, so we have a whole house filter that’s carbon-based that filter a lot, and then I have a under the counter filter where I drink my water, and like you know, make smoothies from, or make my coffee from, or use for cooking like that’s all RO. And so we have a little mineral support supplement that will add minerals back in. Because the biggest problem with RO water is the depletion of minerals but, um, I’d rather always have the water cleaner and then add minerals back. It’s always easier to add minerals back than take toxins out.

Evan Brand: Right. Yeah.

Dr. Justin Marchegiani: Always easier.

Evan Brand: For sure, for sure. I mean, yeah…

Dr. Justin Marchegiani: So like, Oh my God! The minerals In the water. There’s no minerals. Like yeah, but there’s no toxins are way less, so now I’m okay with way less toxins and just being able to add a good trace mineral support back into the water.

Evan Brand: Yep! Yeah, and people…

Dr. Justin Marchegiani: And you can do like, a redmond. You can do like a redmon’s real salt, you could trace mineral support with some extra potassium and magnesium-all that’s fine.

Evan Brand:  I’ll do some of the sea water too. Like some of the sea water like, quinton and there’s a couple other professional brands we use of sea water, that stuff. I tell you, I was kind of skeptical. I’m like how is adding like, basically salt water going to help me bit, it sure did. I mean, it definitely is like a thirst quencher. So it’s pretty remarkable the difference.

Dr. Justin Marchegiani: Well, yourself, your cells need uh, they run on a sodium-potassium pump. There’s this gradient of minerals on wither side of the cell. I think it’s what sodium, sodium is on the outside, potassium’s in. It does a little switcheroo. Sodium goes in, potassium goes out, and you need that gradient to happen for the cells to communicate properly. So it you’re low in sodium or potassium, that sodium potassium pump is not going to work optimally.

Evan Brand: you can feel it. I’m telling you. It’s, it’s significant. All right. Let’s hit on some of like, the detox strategies if you’re ready. I think the easy one…

Dr. Justin Marchegiani: So the first thing is all the lifestyle stuff. That’s foundationthat we stack up. So easiest thing out of the gate is going to be glutathione. So glutathione, whether it’s s acetyl, lyposomal, reduce, whether we do, whether we’re making it with all the precursors like, NAC, ALA, glycine, collagen, right? All these things are going to be really important to help make your master antioxidant out of the gates-that’s probably the big one first.

Evan Brand: Yeah, glycine’s huge, and there’s actually some papers just on glycine by itself in isolation helping with glyphosate which is awesome. So I actually take glycine before bed. It really helps sleep too. So that’s another cool benefit but…

Dr. Justin Marchegiani: Yeah, you can mix collagen, peptides, like I use my TrueCollagen with a little bit of magnesium powder before bed. That knocks it right out and glycine’s helpful with other toxins like strippers like xylene and things like that. It will, it will detoxify xylene-thses kind of chemicals too. So glycine is excellent, and then of course um, you know, roundup’s very destructive on the gut and so if you’re doing glycine, it’s very helpful to kind of heal the enterocytes and repair those too.

Evan Brand: Yeah. I would say probiotics are somewhere on the list now. I don’t know in terms of priority and the mechanism is the same as it is for mycotoxins. There’s some cool research coming out about probiotics actually being able to convert toxins into less toxic forms, and then that makes them more water-soluble, and able to excreted from the body. So there’s some cool mechanism involved with probiotics and of course, if you’re working with a practitioner like us, we’re going to coach you through when and how, and what we’re going to use. But that another cool piece of the puzzle. I’d say my next one is going to be micronized chlorella. There’s a couple professional that we use of it, and this is better than the broken cell wall chlorella because, it’s smaller molecules, and then that’s going to allow better transfer across the blood-brain barrier to get some of these heavy metals out. So we’ll actually use some products that are basically designed for heavy metals but, we’ll use them off-label for like mold and chemical detox.

Dr. Justin Marchegiani: Yeah, and so like I have a heavy meal clear product that has some of the, some of the chlorella in there. It also has some of the sodium alginate, and then also some of the modified citrus pectin. These are really good binders that will help with metals and they’ll also help with uh, pesticides too which are great, and then, um, some of the research you’re talking about probiotics actually converting some of the mole toxins and also, they also have an effect binding them too. It’s that what you’re saying too?

Evan Brand: Yeah. I know it’s a conversion. I don’t know if it’s actually binding but, there’s a lot of like great planes they’re doing a lot of work on like promoting the idea of probiotics being like the universal mold detoxifier now – even better higher rated that charcoal for example, which is crazy .

Dr. Justin Marchegiani: That’s why we always talk about dealing with the gut and working on the gut before we push any crazy detox because we know, the gut’s so important. It’s like a lot of these functional medicine principles are like you know, they’ve tried and true but, if you look at the science, like you find more little nitty-gritty within the science of what’s happening, why that is the case like we just kind of know clinically, you get better results doing it so we kind of go that way, and then we just see more data kind of just supporting that hypothesis.

Evan Brand: It’s cool. Yeah, it’s fun because you and I have been basically using the methods we use for years, and then new stuff comes out that’s like, “Oh, cool!” Well, we were doing that already; now we know that it was actually doing other things that we needed it to do for. It’s like get rid of toxins. So that’s, so that’s awesome. How about sauna too? I mean, sweating has been proven to help excrete so many things. I’ll tell you, you know, I had a lady that was in her 70s. We ran a chemical profile test on her. This lady’s test was so clean, I was almost in disbelief because I’ve seen 5, 6 year-old children that are just off the charts with chemicals, and then we have this lady in her 70’s who you think just lived through all sort of different eras of toxicity. Man, I tell you, her chemical tests were as clean as a whistle. I said, “What are you doing?’, and she was in a sauna three to four times a week for half an hour. I said “Wow!”, I said, ”You are living proof that the sauna works and that sweating is an incredible detox pathway.”

Dr. Justin Marchegiani: I see a lot of women, too. Like “Oh, man! I’m pregnant.Like, what’s the best way to detoxify when I’m pregnant?” I’m like, well number one, we don’t want to really push any detoxification. The only thing I may gently recommend is maybe a little bit of a, kind of a natural fiber, eating organic, drinking lots of water, and maybe a little bit of an infrared sauna. But you have to shower right afterwards just because you don’t want to move toxins to the skin, and then have them reabsorb back in. So you want to make sure you use a good 10 sulfur soap, break up that film of toxin on your skin so it flushes off your skin. So would you agree that you know, potentially doing a little bit of sauna therapy as long as you’re not depleting yourself, dehydrated, is probably a safe, probably one of the more safer, gentle ways to detoxify if you are pregnant?

Evan Brand: I guess it depends on temperature. Like I’m not going to put a lady in like, a hundred and eighty, like a hot rock one.

Dr. Justin Marchegiani: Yeah.

Evan Brand: I think an Infrared one…

Dr. Justin Marchegiani: It can be infrared were it’s lower temperature.

Evan Brand: Yeah. I think if you’re probably at like a 125 degrees or something. That’s somewhat natural that you could experience on the planet. I think would be no problem; the chlorella should be no problem, too. You know, we’ve actually…

Dr. Justin Marchegiani: Stays in the gut. It stays in the gut. You’re probably okay, I mean, chlorella, some kind of a gentle, more food-based binder is probably okay. I mean, if you’re gonna do some kind of a sauna and you’re pregnant, one, make sure you’re hydrated, make sure you have minerals. Start with like, three or four, or five minutes, and just kind of add like a minute of two every time so you don’t overdue. I always rather know you go at a lower level where you’re confident- you can handle it, and gently nudge it up, and just make sure you shower right afterwards. It’s probably the only detoxification means that I would really push outside of a gentle binder. Uh, that’s food-based for my pregnant females. Back on that, would you agree?

Evan Brand: I would say, I, I don’t see a problem with charcoal and chlorella during pregnancy because, you have to kind of weigh the pros and the cons, right? And we know that for example, these toxins go through the placenta. We know they go through breast milk, so here you are, willingly letting this toxins go through the unborn baby, when you could simply  use a gentle binder to try to mitigate some of that or even detox; that there’s actually been crazy stuff being done behind the scenes. I won’t go into too much details because I don’t think it’s published yet but, showing that these micronized chlorella molecules can literally detox the baby before the baby’s even born. So you can actually have a baby come out cleaner than it would’ve been, chemical wise, by being detoxed throughout the pregnancy by the transfer of the chlorella from mom to baby; and then of course, once the baby’s born, through the breast milk, also there is some transfer of chlorella. So there’s some crazy, crazy stuff coming out on that but, too soon to say exactly.

Dr. Justin Marchegiani: Very cool. I like that. So, yeah. We have our binders, we like the binders, and again, talk to your, your OB if you’re a person that wants to look into that. When you’re pregnant, just be careful. I always recommend do all this stuff before but, if you waited and you have issues, and you got to do it now, talk to your OB, talk to your functional medicine doc before you ever do that. We typically don’t push any hard detoxification when uh, patients are pregnant just because we’re mobilizing a lot of toxins unless, we do it very very gentle-way like we mentioned before. Uh, outside of that, I would say we talked about all the big binders of water filtration. We’ll put some links down below with some of the RO and whole house activated charcoal, carbon-based filters that I personally use and Evan uses. We’ll put some recommended links that you guys have that. That’s going to be really important. I’d say air, water, organic food-those are going to be big, and then we can set them in on top of that. So uh, in my line I use heavy metal clear, my detox aminos that have calcium gluconate, and all the sulfur aminos, and reduced glutathione. Evan has some similar glutathione, and sulfur, and mineral-based products that are mineral, that are like our binders, like fulvic minerals or things that help bind up some of this things, too. So we’ll put some links down below if you want some recommended products that we personally use, and we’re kind of gave you some of the big mechanism, right? One’s binding, right? You’re binding some of it up, and the other one is you’re working on enhancing your own detoxification pathways, so they can excrete them. And then of course, low-hanging fruit, right? The solution to pollution dilution. You take any toxins, you hydrate well enough, good clean water and minerals, the more you hydrate that mineral, that toxin becomes less potent, the more it’s diluted. So that’s, it’s low hanging fruit. It’s easy to forget but, solution to pollution is dilution.

Evan Brand: Cheers! Yeah, and this is real stuff. I mean, we’ve seen many, many, I mean, hundreds of this point; before and after case studies of measuring these chemicals. It’s absolutely remarkable what can be done. So if you’re just like, “Oh, toxins are bad.”, and that’s all you get from this podcast, no. Remember that goes deeper than this. We’re talking the way you perform in terms of your mitochondreal function, your energy levels, the health of your gut. Whether you have bacterial overgrowth which then leads to bloating, and burping, and gas, and issues with your joints and potential autoimmune issues because now you’ve got chlostridium overgrowth. So if you hear this, all you think is” toxins are bad, I need to detox.”, no. Remember, this goes into every body system. This goes into adrenals, mitochondria, liver, gallbladder; I mean, the whole system is involved so don’t just blow this thing off. I still see people-I won’t name her but, there was a lady I knew from my, my town. Now she’s super big and she’s got a supplement company that’s like all these vitamin shop stores and everywhere, and she did a Q&A, and I mean this lady is a multi-millionaire, and people asked her, “Do you eat organic?”, and she said “No. I think it’s a waste of time.” It’s like you’re just, you’re just, uh, what’s the word? Not dumb, that’s the rude word. Uh…

Dr. Justin Marchegiani: Ignorant.

Evan Brand: Ignorant. She’s ignorant. Yeah, that’s the word. She doesn’t know what that means. Like how important that truly is and how that’s changing everything from her offspring, and the health of her babies to her own health. So to people out there, if you’ve got the means to do it, which hopefully everyone can, I can see people have that brand new iphones but then they say they don’t have the extra dollar to buy the organic strawberries. You got to make thins thing a priority or you’ll see a brand new Mercedes SUV in the McDonald’s parking lot, like you’ve got to make organic a priority.

Dr. Justin Marchegiani: Yeah. Absolutely. So you git to make it a priority. It’s shift that for sure, and again, people’s say organic’s a fad. Well, again, before 1950, everything was organic, right? That’s where the pesticide kind of fertilizer industry came kind of post-World War II, and so, everything was organic before that point. And again, like first thing I recommend in the order of priorities is, make sure your meat are organic and pasture fed first, okay that’s the first order of, um, let’s just say investment. The second thing is, eat from the clean 15-these are pesticides that have, these are foods that have a pesticide load; and then, avoid the dirty dozen. That’s kind of environmental working group thing. So we’ll put a link for the clean and the dirty dozen; and then from there, you can start getting organic vegetables that are frozen; that’s cheaper. And then of course, start to buy them, you know, more fresh and organic across the board but, that’s kind of the progression. So just try to at least start with the meats because the meats hold the most toxins, and so fats are in the toxins. So you want to start with meats first, and then you can work on going to clean 15, avoid dirty dozen, frozen organic, and then full fresh on organic. That’s kind of the algorithm there. Anything you want to say about that Evan?

Evan Brand: Yeah, local too. I mean, if you can get local beef too, where it hadn’t traveled thousands of miles from Brazil, and they didn’t cut down the rain forest to get that grass fed beef, then I would totally do that. I get my meat from 15 minutes down the road. It’s just hundreds, and hundreds of acres of beautiful chemical-free pastures. So I feel really good about it.

Dr. Justin Marchegiani: That’s great! I love it. Well, very good. So out of the gates here also, one last thing, if you don’t have good gallbladder function, or good digestion, right? You’re constipated, you’re not pooping everyday, you’re having a hard time digesting food, not breaking fat down or protein adequately, your stools are floating, excessive skid marks streaks-those kind of things that means you’re not breaking down fat, you’re not breaking down protein adequately, you’re not moving toxins through your bowels adequately, you’re gonna be reabsorbing that, you’re gonna, you’re not gonna have good gallbladder flow to push that out in the stool. So you’re potentially reabsorbing or not eliminating toxins via your digestive tract. And so if we have digestive issues, we got to have some stool testing, we got to fix whatever is going on from a microbial imbalance or gut infection in the intestines. That’s really important. Got to work on live, gallbladder, and making sure enzymes and acids are adequate to break everything down.

Evan Brand: Yep! Good call. And if you need help, you want to get some of this testing done, investigate your gut, look into your chemical toxicity, you can reach out to Dr. J or myself. This website is justinhealth.com if you need to reach out, it worked worldwide (facetime, phone, skype) any way you need to connect there. So justinhealth.com, and for me Evan, it’s evanbrand.com. We look forward to helping you. Also reach out. We offer intro calls too! You can chat with us and figure out exactly what’s going on, symptom wise, we’ll see if you’re good fit for care, and look forward to helping you out.

Dr. Justin Marchegiani: Yeah. We’re here for you all, guys. Awesome! And if you enjoyed it, thumbs up, comments down below, and um, we’re here! Justinhealth.com, evanbrand.com, and write us a review too! We appreciate it.


References:

https://justinhealth.com/

https://www.evanbrand.com/

Audio Podcast:

https://justinhealth.libsyn.com/the-top-5-anti-aging-techniques-to-age-gracefully-podcast-342

Recommended products:

TRUCOLLAGEN (Grassfed)

Organic Grass Fed Meat

Air Doctor Air Purifier

Austin Air Health Mate Plus

Magnesium Supreme


The entire contents of this website are based upon the opinions of Dr. Justin Marchegiani unless otherwise noted. Individual articles are based upon the opinions of the respective author, who retains copyright as marked. The information on this website is not intended to replace a one-on-one relationship with a qualified health care professional and is not intended as medical advice. It is intended as a sharing of knowledge and information from the research and experience of Dr. Justin and his community. Dr. Justin encourages you to make your own health care decisions based upon your research and in partnership with a qualified healthcare professional. These statements have not been evaluated by the Food and Drug Administration. Dr. Marchegiani’s products are not intended to diagnose, treat, cure or prevent any disease. If you are pregnant, nursing, taking medication, or have a medical condition, consult your physician before using any products.