Dr. Kelly Brogan – A Mind of Your Own – Podcast #165

In today’s video, Dr. Kelly Brogan, an accomplished doctor and author of the New York Times bestselling book “A Mind of Your Own”, joins Dr. Justin Marchegiani as they both discuss the link between gut issues and mental health. Get some useful tips on how to keep your mind clear and active without gut issues hindering it. Get your own mind back with the help of functional medicine. Let’s watch and listen!

Discover some natural ways to be more productive and learn about the different ways to address brain and gut inflammation. Also, stay tuned for some more information about Dr. Kelly’s bestselling book, “A Mind of Your Own” and viral articles.

In this episode, we cover:Dr. Kelly Brogan - A Mind of Your Own - Podcast #165

02:41   Depression: Illness of Modern Civilization,

Not a Chemical Imbalance 

04:53   Animal Model of Depression

08:20   Multiple Different Lifestyle Pillars

12:00   Meditation and Productivity

16:42   Supplemental Ways to Address Brain Inflammation

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Dr. Justin Marchegiani: Hey there. It’s Dr. Justin Marchegiani. Today’s podcast, we have a great guest.  Dr. Kelly Brogan in the house. Kelly is wicked smart. I’ll bring up my Boston ex. You went to MIT Undergrad in Cornell from Medical School. So, it’s a privilege to have her here. She has a New York Times bestselling book, “A Mind of Your Own.” Did I say it correctly?

Dr. Kelly Brogan: That’s right? [crosstalk] You got it.

Dr. Justin Marchegiani: A Mind of Your Own, really looking at natural solutions to get your brain back on track and move back on track. And one of the things about Dr. Kelly that I love so much is she looks at how mood is connected with the gut. Because most people, they just want to throw a medication to fix the brain. They fix the symptoms but not actually get to the root cause, which can be in the gut. So, Dr. Kelly, welcome to the show.

Dr. Kelly Brogan: Thank you. Total pleasure to be here.

Dr. Justin Marchegiani: Excellent. Well, tell us a little bit more about your self, ‘cause you went down this conventional medical rabbit hole, right? MIT, Cornell– You’re diving in deep– you do your residency, uhm– and you’re kind of learning all these conventional treatments for Mood disorders, etc. How did you come out of that alive? And how did you get your training to get to the real root cause and the functional medicine side here.

Dr. Kelly Brogan: Yeah. So, you know, I come from a very conventional mindset, and I was raised by uhm– an immigrant mom. And anyone who has immigrant parents knows that, basically, you follow the rules; you become a doctor, a lawyer and you’re supposed to be making a lot of money.

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: And that was essentially, you know– My effort uhm– was to become a doctor. I thought, you know– I figured out through my work on a suicide hotline, actually, at MIT, that we’ve cracked the code of human behaviour. We know that these are genetic illnesses that are reflected as chemical imbalances that require pills for lifelong management. Cool! You know, I’m gonna participate in that model. And so, it really wasn’t into my own, sort of uhm– health journey, which is what you’ll all hear from any turncoat doctor. We had a personal experience where we bumped up against the ceiling of what conventional medicine has to offer. And we learned a broader version of the truth. And uh– you know, I’ve always been a Science Nut. I’m very comfortable on pubmed.com, and I went and researched for myself, you know– the truth about everything I learned in medical school and residency and fellowship. Uh– and what I learned was pretty jaw-dropping. I was ready to hear it though because I had already had my own uh– experience of putting an autoimmune disorder into remission through nutrition. And so, you know– what I learned is that depression, for example– Let’s just talk about depression because it’s a– It’s a emblematic of these more systemic issues in our medical system. But, uhm– it’s not a thing. It’s not a disease in a way we were told it was. And, you know, what I– what I learned through my review of the medical literature is that in six decades, you know– we’ve been trying to validate this idea that depression is a chemical imbalance. The science just isn’t there. I was shocked because I can’t tell you how many hundreds of patients I’ve sat with and I said, “You know, you have a chemical imbalance. It has something to do with Serotonin or Dopamine or Epinephrine, and you know– you need to manage it. And the sooner you accept that, you know– the easier your life is gonna be.” So patronizing. You know, I’ve said that to countless patients. And when I looked to the Science, it just wasn’t there. But, what is there, interestingly, is a science that frames depression as uhm– an illness of modern civilization, right? So, it’s a response on the part of the body, mind and spirit, uh– you know, to the kinds of stressors, exposures, triggers, toxicants that we are encountering today, that we just haven’t evolved to accommodate. And perhaps, we never will. Perhaps we’re not even meant to, right? Because…

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: …of– of wrong living today, and– and the way that the natural world will ultimately ask us to get back in line. And– and one of the ways that– that asking happens, that– that invitation’s delivered is through symptoms. So, uh– you know, I found  that there are actually a lot of reversible causes of what we are calling depression.

Dr. Justin Marchegiani: Interesting. Very good. And I see a lot of patients, clinically, right? ‘Cause I’m working with patients making diet changes or cutting out gluten, grains, refined sugar, a lot of the inflammatory foods, or cutting out a lot of the bacteria in the gut that has this compound called LPS or lipopolysaccharide. And, you’ve talked about that kind of getting into the bloodstream and making its way to the brain, and creating mood issues there. Can you elaborate more on that?

Dr. Kelly Brogan: Yeah. So, you know, I think it’s fairly intuitive for most people– you know, that the gut and the brain are connected, right?

Dr. Justin Marchegiani: Hmmn.

Dr. Kelly Brogan: You felt nervous about giving a speech and maybe you lost your appetite or you have diarrhea, or something like that. And that makes intuitive sense. But, the other direction– you know, the gut to brain direction, is really something we’re just beginning to develop scientific comfort with. Although it’s been actually several decades since it’s emerged in the literature. When it comes to depression, it’s interesting because the animal model of depression– There is such a thing. In the animal model of depression, the way that they induce it is to inject– Systemically, right?– in these rodents, LPS, as you mentioned. So this– this compound in a grand– grand negative bacterial balls. And the deal is that it’s not meant to be sort of circulating around. So, once it’s breached that gut-brain uh– Sorry– that gut barrier..

Dr. Justin Marchegiani: Yes.

Dr. Kelly Brogan: …then it can alert the immune system to the need of greater inflammatory response at the gut level. It’s all by design. Everything that the body does makes sense if only we have the mindset and framework to, you know, receive that uh– information. So, you know, through this lens, uhm– the inflammatory response that ultimately results in the symptoms of depression, which are what? Sleep disturbance, social avoidance, changes in appetite, for example, changes in  motivation, fixation on very specific thoughts, uhm– you know, the– the– the driver of that perhaps could be reduced to a gut insult. So, where do gut insults come from? Most of the time, through what we put in our mouth…

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: …right? So that means that we are empowered to make changes to our brain behavior and cognition through diet, you know. And of course, now we have science that shows that within seventy-two hours of changing your diet, you change that ecology in your gut, your microbiome. Uh– and so, I totally agree, you know, that there are certain foods that really moved the needle quickly. They also happen to be foods that are very addictive in nature, right? You know, things like, wheat, dairy, sugar, alcohol. I actually stored coffee in that mix. I know that’s little controversial.

Dr. Justin Marchegiani: Hm– Mmhmn.

Dr. Kelly Brogan: Uh– but, you know, so– so, not only are you seeing what you look like without these addictive foods, but you’re also engaging in a pretty deep exercise of changing your gut ecology. And, you know, we could talk about the role perhaps of certain kind of starches in, you know, feeding gut bacteria, ‘cause that’s, you know, part of my approaches to restrict those for the first month.

Dr. Justin Marchegiani: Got it. Interesting. And what’s your experience treating patients ‘cause, clinically, I treat– well, fifty patients a week in my virtual clinic here in Austin. And I’m running Stool test–  sometimes, even multiple Stool tests on different patients, and I’m saying, you know, obviously, “Your SIBO type of overgrowth.” “You’re Methane and you’re Hydrogen overgrowth”. And then, I’m seeing infections like, Blasto, Giardia, and Cryptosporidium, E. histo and H. pylori. What are you seeing in your patients? Are you kind of seeing a similar imbalance of those creatures.

Dr. Kelly Brogan: It’s interesting because I– you know, when I departed conventional medicine, my first deep dive was into functional medicine.

Dr. Justin Marchegiani: Mmhmn.

Dr. Kelly Brogan: Uhm– and that’s, you know, uh– I was certified through ADIHM, and I was very interested ‘cause this is how my mind works…

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: …in quantifying every aspect of my patients’ existence, right? So, I wanted blood and saliva. I wanted hormone testing. I wanted Urine analysis and I wanted Stool analysis. And I did that for several years– yeah, almost a decade, into this work. Uhm– until I came upon uhm– a deep desire to bring this opportunity to more and more people. Perhaps you couldn’t necessarily afford all that testing, or for whom it was just overwhelming, right? And so, somehow, I arrived at the point today, where my approach is actually quite simplified. Such that, I actually come to believe that if you recruit the synergy of multiple different lifestyle pillars. And they’re pretty basic, right? Pretty familiar, too, obviously. So, detoxification…

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: …looking at daily contemplative practice. Of course, I’m– have my specific opinion on what I believe is one of the more powerful types. I’m Kundalini Yoga uhm– Instructor.

Dr. Justin Marchegiani: Nice.

Dr. Kelly Brogan: And, also the role of a strict commitment to a therapeutic diet for the space of the month. So, in working with these pillars, even without testing at all– So, in my online program, we don’t do any labs. The outcomes that I have gotten actually more rapid and more robust than when I was mired in the weeds of testing. But when I was, I actually found that there are some common uh– reversible drivers of diagnosis of anxiety, of depression, even OCD, panic attacks, ADHD, Chronic Fatigue– In my practice, the one of the most common ones was blood sugar imbalance, so…

Dr. Justin Marchegiani: Totally.

Dr. Kelly Brogan: …big one, right? Uhm– so you could test for that. You can diagnose reactive hypoglycemia, or you know you can just do a dietary intervention for ten days and see if that was part of the deal for you, right? So, another big one is wheat and dairy indigenousity. So again, you can test for that or you can just take it out and see how you do. Another big, big, big– big one, probably upwards of 80 percent of my patients have a diagnosis of Hashimoto’s, often…

Dr. Justin Marchegiani: Totally.

Dr. Kelly Brogan: …perhaps driven by mimicry like you’re talking about e– Epstein-Barr, uhm– for example, uh– you know, infection. Uhm– Hashimoto’s, Graves, Postpartum Thyroiditis are big– what I call, psychiatric pretenders, right? If you do not know that you have this going on, you could land your self on Zoloft and Lithium, or more. And that’s why this kinds of testing– unless you’re really committed and you just know, you’re not gonna go the medication route– you know, this kind of testing can really– potentially even, you know, save your life. I’ll be that dramatic about it. Uhm– and, you know, and then, of course, I’d become very passionate about the untold side effects of other common medications, right? So, as drivers of psychiatric illness, so things like birth control pills and acid blockers, statins, antibiotics. Uhm– so, you know, sometimes it– it– it needs to be looked at through the eyes of an expert like yourself. Uhm– but sometimes it’s really simple. You know, and– and engaging in this kind of uhm– you know, pillar approach can– can be really all you need.

Dr. Justin Marchegiani: Very cool. Just curious. Can you give us like uh– a day in the life of Dr. Kelly. What does your diet look like, Breakfast, lunch, dinner?

Dr. Kelly Brogan: Yeah. So that’s the interesting uhm– part about this kind of like holistic medicine, if you want to call it that, is the power of your potential to influence and heal patients, I believe, is in direct proportion to your ability to walk the walk, right?

Dr. Justin Marchegiani: Totally.

Dr. Kelly Brogan: So, you know, you transmit something to the people you are looking to help, simply because you’re living that life. So, I– you know, I walk the walk completely, you know. I asked many of my patients to do coffee enemas, for example, which I learned from my mentor, Nick Gonzalez. And you know, if II didn’t do them, how would I ever convince someone else that it’s effective? And this is why meditation is a tough one for me because I follow the literature on meditation for many years and I never did it. I was too busy. Meditation was for other people. And everytime I sat down to do it, I hated it. I hated the experience of just being with myself and being with my crazy mind, right? So, until i broke through that barrier and actually committed to a daily practice– Now I have a pretty strong 45-minute daily practice…

Dr. Justin Marchegiani: It’s great.

Dr. Kelly Brogan: …predawn. But, you know, until I did that, I didn’t– I don’t think I convinced a single patient to meditate. You know, we both sort of thought it was a good idea. They weren’t doing it. I wasn’t doing it. So, you know, the real game changer for me, personally, ‘cause I heal my Hashimoto’s mostly just through dietary change uhm– in almost eight years ago now. Uhm– and my life really changed. I’ve really rewired my nervous system and my productivity performance and aligned it with my flow, changed dramatically when I started meditating every single day. And, specifically, when I started meditating before sunrise, uhm– everything changed. You know, I used to be up until 2 in the morning, working. I’m a total workaholic.

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: I wake up everyday dying into this work. I love this work. I– I would do it for free, forever. You know, this is what I’m here to do. But, I would work ‘til two in the morning regularly. And you know, in New York, that’s– it’s the culture here.

Dr. Justin Marchegiani: Totally. [crosstalk] Hustle and bustle.

Dr. Kelly Brogan: Totally. Exactly. Totally sanctioned. So, you know, I uhm– When I started meditating at 5:30 in the morning everyday, which I started after in the setting of grief uhm– you know, after my mentor died. It’s the hardest thing I’ve ever dealt with…

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: …in my life.

Dr. Justin Marchegiani: Roger that.

Dr. Kelly Brogan: I was desperate.

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: Yeah. I was totally desperate, and I did it. The nest day, I woke up and I have never missed a day since. Uhm– but, if you’re waking at 5:30, you can’t go to bed at 2:00 AM, right?

Dr. Justin Marchegiani: Totally.

Dr. Kelly Brogan: Or you’re gonna be in trouble [inaudible]

Dr. Justin Marchegiani: Totally.

Dr. Kelly Brogan: So now, I go to bed at nine. Do you know how revolutionary that is for a New Yorker…

Dr. Justin Marchegiani: It’s amazing.

Dr. Kelly Brogan: ….to go at bed at 9:00 PM? And–  and you would think, “Oh, I’m missing– you know, what is that?– five hours of productivity.”

Dr. Justin Marchegiani: Totally.

Dr. Kelly Brogan: Like, how do I even keep my business afloat. Uhm– but my performance– and again, sort of alignment with– just things unfolding, everything happens exactly, you know, the moment I need to. I don’t need to drive this ship. You know, that’s one of the sort of secret pearls in self-care that you wouldn’t otherwise believe unless you’ve had the experience. So, i’m a big believer in foregrounding self-care as being really my only responsibility. All I have to do every single day is make sure that I have committed, again, to taking care of my self. And the rest is gonna. Is gonna be exactly how it needs to be.

Dr. Justin Marchegiani: Very cool. So, I think I missed it. What was breakfast again, typically, for you?

Dr. Kelly Brogan: So, I have this uhm– smoothie often. It’s so funny because sometimes I’ll write a blog that I, you know, spend weeks and weeks and weeks researching. It’s like, you know, ten, 15, 20, 30…

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: …represent it. And like four people will read it, right?  

Dr. Justin Marchegiani: Mhmmn.

Dr. Kelly Brogan: And then, one day, I just decided to write uh– the ingredients of the smoothie that I put uh– together. Okay, it’s like egg yolks, coconut oil, uh– plus/minus coconut oil. Uhm– nut butter, frozen organic cherries. It’s collagen powder, uhm– coconut water.

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: Just, yeah. Basic– basic stuff, but it’s not a green smoothie, right? Uhm– it’s not a ton of Kale and Spinach or anything like that. And it was– It’s like, to this day, the most viral thing I’ve ever written. [laughs] It’s just breakfast, [crosstalk] right?

Dr. Justin Marchegiani: Love it.

Dr. Kelly Brogan: Because if you struggle with blood sugar stuff, like I did, uhm– like many of the people I work with do, It’s like, within the day resolution. Like within one day, you can turn that around. You’ll feel what it is to put, you know– It’s two tablespoons of ghee. Put that much fat into your body for breakfast is an unusual thing uhm– for most people, and it tastes delicious and you actually feel full for some times, double-triple the amount you would have otherwise. So, that’s why I’m actually big– I’m glad you asked– big believer in just beginning with changing your breakfast. Like if you are not ready for the rest of it, just start with there. And see…

Dr. Justin Marchegiani: Huge.

Dr. Kelly Brogan: …how different you can feel.

Dr. Justin Marchegiani: I love it.

Dr. Kelly Brogan: Yeah.

Dr. Justin Marchegiani: ‘Cause stabilizing that blood sugar is so important. ‘Cause when your blood sugar goes on highs and lows, you get the Hyperinsulinism, which is gonna create all kinds of problems in your hormones. If you’re a woman, it will turn you into a man, uh– by getting the PCOS stuff going, and if you’re a man, it will turn you into a woman by upregulating aromatase. So, you have that side of the fence. And the blood sugar swings. When they go low, you’re gonna get a lot of Cortisol and Adrenaline, which can create mood issues and create that anxiety and that may be the reason why you’re on the Xanax. [crosstalk] So the other moods stabilizes, right?

Dr. Kelly Brogan: Exactly. [crosstalk] You said it so I don’t have to. That’s exactly it. It’s powerful. I mean, I have patients who’d have six panic attacks a day. They’ve had three medications heading to Electroconvulsive Therapy. And all that was going on was Dysglycemia.

Dr. Justin Marchegiani: Huge. [crosstalk] Huge. Now we have these cells in our brain, also called the glial cells, and a great portion of the cells in our brain are actually immune cells, which is interesting. And once these cells get activated from stress or inflammation– it’s like  positive feedback loop. It just gets more and more and more. Uhm– what do you do to help decrease brain inflammation? I think you’ll talk about the gut, but is there anything you do supplementally to help decrease that brain inflammation?

Dr. Kelly Brogan: Yeah. So that’s where I am a big believer in this multi-pronged approach, right?

Dr. Justin Marchegiani: Hmmn.

Dr. Kelly Brogan: Because, if we’re– if we’re looking at an anti-inflammatory diet, the typical template of a diet I recommend is not gonna be any major surprise uhm– to anyone– but, the Vegans probably, because it’s uh– you know, a classical sort of ancestral diet. You know…

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: It was animal food. You know, the nuts and seeds– all vegetables…

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: I restrict resistant starch for the first month. Uhm–

Dr. Justin Marchegiani: like a Paleo template, basically.

Dr. Kelly Brogan: It’s a Paleo template, basically. Includes, uhm– some starchy vegetables, but not uh– white potatoes. So, just to restricting…

Dr. Justin Marchegiani: Nitrates.

Dr. Kelly Brogan: …they always– Nitrates are included, so tomatoes are fine. Eggplants are fine. You know, mushrooms are…

Dr. Justin Marchegiani: Just the potatoes, okay.

Dr. Kelly Brogan: Just the white potatoes. And uhm– and you know, otherwise, my patients do always reintroduce things like white rice, gluten-free grains, uh– legumes. So, it’s not a long-term Paleo diet. It’s just restricted for that first month. Uhm– so that we can understand what resistant starch does to your microbiome, basically, because when you reintroduce potatoes– Do you have gas and bloating? You know, Are you super tired after you eat white rice? We just want to know that, right, for these potent starches. Otherwise it’s not that uhm– dramatic, but it is– just have this anti-inflammatory effect, ecologically rebouncing at the gut level. And then the meditation components, I just think, as one of the meditations I often recommend is called Kirtan Kriya Carer or _____[18:13]. It’s been studied in  randomized trials, actually, for changes in brain level profusion. Uhm– and the subjective outcomes in terms of resolution of cognitive impairment and Dementia patients, who we have nothing to offer, you know, on a pharmaceutical level. So, literally, all they did was 11 minutes of this meditation every single day.

Dr. Justin Marchegiani: Uhmn.

Dr. Kelly Brogan: So, i’m a big believer in the potential of this ancient  technologies to send that signal of safety at the brain level. And then, of course, you know, when you’re engaging in detoxification– even if it’s as simple as taking the pesticides out of your diet.

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: Uh– You know, we’re fundamentally changing the way the immune system is being triggered. And as you said, you know, we have evidence that from a gut level, and also from a psychosocial stress level, we could mobilize the immune system in the– in the systemic circulation. That then tracks back to the brain. And like you said, kicks off that alarm. You know, when i was in med school, we don’t even know that the brain had an immune system. We thought that it was a privilege region.

Dr. Justin Marchegiani: It’s crazy.

Dr. Kelly Brogan: We didn’t know that what’s inside of the brain. You know, we’re just discovering basic anatomy, still, at this point. So, it’s important to work with the tools that do the least harm.

Dr. Justin Marchegiani: Very good. Now, I’ve seen you write this, and I may be off in a little bit. I’ll just throw it out there and you can correct me.

Dr. Kelly Brogan: [nods]

Dr. Justin Marchegiani: You know, you’ve talked about the brain-gut connection with mood. Now, being a functional medicine physician, I’m addressing everything: diet, lifestyle, blood sugar, [crosstalk] all the body system, hormone, detox. So, we’re never ever putting in on one magic pill.

Dr. Kelly Brogan: Yeah.

Dr. Justin Marchegiani: But as we fix things, I do see certain amino acid nutrients with certain nutrients, like B6, and certain B vitamins. I have seen that significantly helped a lot of people on the mood side, not every time. So, I know the SSRIs and some of these medications, we think they work by just blocking reuptake of some of these chemicals but that may not be the case. So, what’s your take on the amino acids? I do see benefits, but I know, you–you’ve talked differently about that.

Dr. Kelly Brogan: Yeah.

Dr. Justin Marchegiani: Things like 5-HTP, tyrosine, ___[20:09], L-dopa; those kind of things.

Dr. Kelly Brogan: Exactly.

Dr. Justin Marchegiani: Yeah [inaudible].

Dr. Kelly Brogan: Yeah. You know, listen. I am a passionate supporter of natural medicine. You know, and there are many, many, many, many different approaches. Uh– I mean I had patients who’d come– not patients. I know of people who come up of psychiatric medications using flower remedies. So…

Dr. Justin Marchegiani: Uhmn.

Dr. Kelly Brogan: …you know, i know that there is not one path here. And that’s the beautiful thing. Uh– but, in my approach, I use no supplements at all for the first month.

Dr. Justin Marchegiani: Uhmn.

Dr. Kelly Brogan: Uhm– when– I don’t begin medications taper, for the first month either. So, in a context of medication taper, then I actually do use amino acids. Uhm–

Dr. Justin Marchegiani: Uhmn.

Dr. Kelly Brogan: I use things uh– you know, the ones you’ve mentioned in particular as a compliment to the purported mechanism of the given medication, and I aIways use a general mix of amino acids. And I find them to facilitate the process. Uhm– I don’t use any supplements as a replacement for medication because it’s not the contraces we’re going for, right? We’re going for uhm— you know, trusting the body, trusting it’s uhm– responses, curiosity about what the body is meaning to tell you. And then also working through a lot of uhm– sort of indoctrinated fear around emotions like, you know, deep sadness, rage, grief– You know, this kind of pain that we are uhm– not, in any way, making space for. You know, to– to investigate with any degree of curiosity because, you know– one of the greatest uh– most meaningful lessons I’ve learned is that on the other side of that process of personal encounter with your deepest, darkest uhm– experience of your mind and body, is a kind of expansive, you know, exposure to these exalted emotions: gratitude, joy…

Dr. Justin Marchegiani: Huge.

Dr. Kelly Brogan: …even bliss. You know, that becomes available to you when you have the courage to sort of walk through that dark night. So that is a big part of my uh– approach.

Dr. Justin Marchegiani: So, some free-form amino acids which is great. What do you do with adaptogenic herbs? I mean, I use Ashwagandha a lot. I find that really help modulate Cortisol, which can thus help along with anxiety and even sleep. What’s your take on adaptogens, and what are your top three favorites?

Dr. Kelly Brogan: Uhm– I would say, I have a top one favorite. [laughs]

Dr. Justin Marchegiani: Okay.

Dr. Kelly Brogan: Because I’m a big Rhodiola fan.

Dr. Justin Marchegiani: Uhh– love it.

Dr. Kelly Brogan: And had been for many years. And it’s one of my first introductions to the power of herbal– you know, herbal approaches and herbal medicine, personally. And, You know, I find that it’s a really powerful compliment, not only to support in cognition at the time when many of my patients have been injured by medications on the cognitive front, uhh– but also that inevitable, you know, exposure to stress. I think it’s a really magical plant to dance with. So, I’m a  big fan of it.

Dr. Justin Marchegiani: What about nutrients? And I say, BC– uh– B6, or P5P, Pyridoxal-5-Phospate, really essential for helping these neurotransmitters activate. What’s your take on the most important nutrients for you that you see makes the biggest bank for your back and also a B6, too.

Dr. Kelly Brogan: Mm– I– I would– In my experience, the most profound single nutrient– because, you know, most of us do offer that as uh– you know, sort of a compliment…

Dr. Justin Marchegiani: Uhmn–

Dr. Kelly Brogan: Uhm– in– in the entire birth.

Dr. Justin Marchegiani: Totally.

Dr. Kelly Brogan: But the one that I had the most miraculous outcomes with is actually B12.

Dr. Justin Marchegiani: Yes. Huge.

Dr. Kelly Brogan: And, you know, through my work with Nick Gonzalez, I’ve had a better ability to contextualize why– that is, in the patients that I work with. They are what he would call parasympathetic dominance, and so they respond especially well to animal-based nutrients, particularly white B12. You know there are cases in the literature of one woman, in particular, who was diagnosed as uhm– having psychotic depression. She was given Electrocompulsive Therapy…

Dr. Justin Marchegiani:  Totally.

Dr. Kelly Brogan: …and uh– multiple medications, and all that she was going on was a B12 deficiency. So, I actually used– have my patients inject themselves uhm– with something like a Hydroxyvaline in a pretty generous dose. Sometimes like 5mg, sometimes several times a week uh– initially, which is obviously considered to be rather aggressive. But uh– it seems to be, you know, quite effective in a short period of time, particularly for uh– you know, cognitive and energy-related impairments.

Dr. Justin Marchegiani: You know, Dr. Brownstein’s also a big form of the hydroxyl form. Why do you like the hydroxyls so much– let’s say, over the methyl or the adenosyl?

Dr. Kelly Brogan: Uhm– I had– I started with a Methocarbamol form.

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan:  I just had a couple patients who uh– felt overly activated by it. You know, like whose are wired by it. And– and again, I’m using large doses, so it could have just been that. Uhm– so I– the hydroxyl form is just a– a way to thread the needle, you know, for those patients who might be susceptible to the– the methyl as [inaudible].

Dr. Justin Marchegiani: And then, do you have any opinion on GABA as well? You know, some people say the molecule’s too big to cross the blood-brain barrier. Others are coming out with liposomal forms. What’s your take on GABA?

Dr. Kelly Brogan: Yeah. I have gone very comfortable using a form called PharmaGABA. [crosstalk] It’s a–

Dr. Justin Marchegiani: PharmaGABA, yeah.

Dr. Kelly Brogan: Yeah. Fermented…

Dr. Justin Marchegiani: The science got it.

Dr. Kelly Brogan: …form

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: Yeah. And, you know, it’s uh– when it works, it works. And who knows if that’s, you know, Placebo. Otherwise, I don’t really care, because if it’s as benign as it is, I’ll apply that Placebo Effect all day long. But I, It’s a fan favorite– you know, of my patients, uh– particularly during the process of moving through a medication taper. It’s a very important uhm– tool.  

Dr. Justin Marchegiani: And then, when you’re dealing with people that are on these medications, whether they’re Benzos or SSRIs, or even Lithium and such. How are you dealing, like– Does every– Can everyone have the ability to get of those medications at some point, and who are the patients you don’t want to like take them off. Where it’s really you got to be super, super slow.

Dr. Kelly Brogan: Mm– Well, it’s my passionate belief that every single person should be offered the opportunity to come up with psychiatric medications.

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: I’ll even go farther to say all medications, period. What the most critical ingredient is uhm– is the mindset, right?

Dr. Justin Marchegiani: Yeah.

Dr. Kelly Brogan: So, believe that it’s possible. It’s the readiness to commit uh– to lifestyle, medicine and to self-care. Uhm– which, of course confers the type of empowerment that’s very necessary to move you out of the dependent and helpless position that you are put in as a psychiatric patient. Uhm– but I had taken patients off of– you know I have videos of my website to prove this, so to speak. I’m publishing cases in the purity of literature. Uh– taking patients of up to medications they’ve been on for 25 years. Uhm– I have patients with histories of Schizophrenia, psychotic mania, suicidal depression. And over and over and over again, they’re shedding their diagnosis and they’re completely and totally off medication. I have yet to fail. Uhm– and I don’t expect to. But, I always screen my patients. I have a very skew population, because of these two criteria– the mindset and the belief.

Dr. Justin Marchegiani: Totally. And then, we’ll put a disclaimer. We don’t want anyone getting after uhm– psychiatric medication on their own. We want them to go back to the Prescribing Physician. But on average– just in general, are you typically tapering off about one to two-month timeframe? Is that generally, where you’re at?

Dr. Kelly Brogan: Oh, wow. No. It can be years.

Dr. Justin Marchegiani: So, years or so?

Dr. Kelly Brogan: I’m glad you asked, because…

Dr. Justin Marchegiani: Good.

Dr. Kelly Brogan: I think I forget sometimes that that’s not uhm– you know, uh– an assumption. So, I don’t touch uh– medication until my patients, in my online program– until they have gone through this month-long commitment.

Dr. Justin Marchegiani: Totally.

Dr. Kelly Brogan: Meditation, detox and diet. Literally, I won’t touch it. It’s a total requirement. Because I used to do it before I require that, and it was kind of a nice idea. We’ll start looking at your diet now. It’s non-negotiable. Okay? So, that happens first, and then the taper is around 10 to 20 percent of the total dose per month is a typical pace. So, it depends on…

Dr. Justin Marchegiani: Got it.

Dr. Kelly Brogan: …what you’re taking. It’s one medication at a time. The process can take years. And, you know what? If you want it to last, and you want it to be a permanently chaptered for you, you have a right with that. You know, because it’s an investment in this being, not just a revolving door where you’re back on meds in a couple of months. Uh– but I– I absolutely do not recommend that anyone consider coming off medications, particularly until they have uh– initiated this kind of self-care and physical healing regiment. And you know, in my program, I have an entire module dedicated to tapering, because it’s not a science, unfortunately. Uhm– and there are very few practitioners who know how to do it. And that’s why patients actually become more educated. Then their provided about how to do it. Uhm– it’s a bit of the wild west at this point.

Dr. Justin Marchegiani: And, is that course over at kellybroganmd.com?

Dr. Kelly Brogan: Yes! We– It’s called, Vital Mind Reset.

Dr. Justin Marchegiani: Vital Mind Reset. We’ll put all the links below. We’ll put the links to the Amazon Book as well, “A Mind of Your Own.” So, everyone that’s listening and finding value. Go support Dr. Kelly by getting that book. That’s great. Now, one last thing here before I let you go, Dr. Kelly. Uh– when I use certain amino acid with patients, even some of the free-forms, I’ll start to notice the patient is starting to have some of the– the side effects, as if the drug’s too much. Do you see that at all? And then, do you start to gradually taper if those higher side effects from the amino acids are making the drug work better? Do you notice that at all?

Dr. Kelly Brogan: That uhm– is possible. I don’t often encounter that for whatever reason, uh– but  that’s absolutely possible. And in fact there’s a proprietary formula called uhm– EMPowerplus by TrueHope. It may [inaudible]

Dr. Justin Marchegiani: Yes. TrueHope, yeah.

Dr. Kelly Brogan: Yeah. And, you know, they counsel about that– you know, that it’s very possible that in the setting of uh– nutrient repletion, that medication could become actually almost quasi-toxic uh– so that you would need to begin to ramp down on the dose of medication at that point. So, it’s– it’s highly possible and that’s an incredible reminder. You know, that nutrients are– are very powerful uhm– tools to be used with strategy.

Dr. Justin Marchegiani: Awesome, Dr. kelly. I think you’re changing the world. I appreciate you coming on the show. Last question for you, “If you’re on a desert island and you can only bring one nutrient, one supplement, one herb– whatever it is, what would that be for you?

Dr. Kelly Brogan: Oh, turmeric, of course. [laughs]

Dr. Justin Marchegiani: Turmeric. Okay. Got it. [crosstalk] Crucumin?

Dr. Kelly Brogan: Yeah, Crucumin.

Dr. Justin Marchegiani: Can [inaudible] can the anti-inflammatory on?

Dr. Kelly Brogan: It’s everything. You know, it’s like a miracle. It’s a miracle herb, and you know the research on it, of course had– had my skeptical mind convinced. You know, with the catalog research on Crucumin, which is one isolate of this…

Dr. Justin Marchegiani: Totally.

Dr. Kelly Brogan: …very complex herb, is astounding. You know, head to head against medications like Cox-2 Inhibitors, antidepressants. It’s extraordinary. So, I think of it as a, you know, the– the power performer, for sure.

Dr. Justin Marchegiani: I love it. Now, is there anything else you want to let the listeners to know? Any new books, products, online things coming out for you that people should be aware of?

Dr. Kelly Brogan: No. Just you know that we’re here to support your journey. If any of these is resident, it is one hundred percent possible for you. I see it every single day. And so, just to make sure that I plant that seed of potential. And oh, you know, we’re here to support. We have tons of free information on this site, and of course, greater uhm– complex products if needed.

Dr. Justin Marchegiani: And let’s hear those links one more time. kellybroganmd.com– the second one was?

Dr. Kelly Brogan: That’s it. You know…

Dr. Justin Marchegiani: Okay.

Dr. Kelly Brogan: …all the information’s there. So let’s just keep it simple.

Dr. Justin Marchegiani: And then the book– if you guys love it, go get that book on Amazon. Dr. Kelly, we really appreciate you coming on the show.

Dr. Kelly Brogan: Thank you so much.

Dr. Justin Marchegiani: Awesome. Take care.

 


References:

www.kellybroganmd.com  

“Vital Mind Reset Program,” by Dr. Kelly Brogan

New York Times bestselling book, “A Mind of Your Own” by Dr. Kelly Brogan

https://www.amazon.com/Mind-Your-Own-Depression-Reclaim/dp/0062405578

“Increase your Brain Health by Changing Your Breakfast: The KB Smoothie” by Dr. Kelly Brogan

https://www.truehope.com/effectiveness/ingredients EMPowerplus by TrueHope

 

9 Ways to Fix Your Gut Flora

9 Ways To Fix Gut Flora

By Dr. Justin Marchegiani

What is Your ‘Gut Flora’?

There is a whole community–a whole universeliving within our intestinal tract. Roughly two pounds of microbes live in and on our bodies; the vast majority of these are located in our gut. With this many guests setting up camp inside of us, we must take precautions, just as we would if we were hosting guests in our homes, to ensure we are only inviting good company.

How Your Gut Flora Affects Your Health

How Your Gut Flora Affects Your Health

Our gut flora is responsible for more than you might realize. It can cause cravings, impact our mood, and affect allergies and food intolerances. By keeping our gut bacteria balanced, we can control how fast our metabolism works, boost our energy, prevent disease, and extract more nutrients from our food. If you don’t have a healthy gut balance, your immune system will be severely compromised. Poor gut health is tied to many health issues and diseases, including:

  • Asthma and allergies
  • Autoimmune diseases (arthritis, IBS)
  • Cognitive decline (Alzheimer’s, dementia)
  • Fatigue and brain fog
  • Fungal overgrowth
  • Gluten sensitivity and other food allergies and intolerances
  • Infertility
  • Learning disabilities (ADHD)
  • Mood disorders (anxiety, depression): The human body has a “second brain” that we are just starting to learn about, located in the gut. Breakthroughs in science are being made on how the trillions of bacteria in our gut— the microbiome— communicate with the neurons in our gut lining. This effectively means the bacteria living inside of our intestines have an effect on our mood! Science is showing depression, anxiety, and other mood disorders are linked to the microbiome.
  • Parasitic infections
  • Small intestinal bacterial overgrowth (SIBO)
  • Type 1 diabetes

Click here if you are suffering from digestive issues to consult with a functional medicine doctor and start feeling better today!

Just as bad bacteria negatively affect your health, good bacteria have a positive influence on your health! Good gut flora assists in the following ways:

  • Gut flora is responsible for helping your body absorb and store nutrients, like vitamin B.
  • It produces vital nutrients. For example, your body doesn’t store or produce vitamin K, and the food you eat can only provide you with a little of what you need. Luckily, your gut flora produces the majority of the vitamin K you require, and since your body isn’t good at storing vitamin K, it’s crucial that your gut flora is always producing more for you!
  • Good bacteria keep the walls of your intestines strong and prevent you from developing leaky gut.
  • Balanced gut flora trains your immune cells to fight inflammation.
  • Good gut flora is energy-efficient.  Having an imbalanced (“bad”) gut flora means your body has to hold on to more food to get the same amount of energy, which causes more food to be stored as fat. On the flip side, if your gut flora is in good shape, you get maximal energy out of the food you eat and excrete what’s left over!

Nine Ways to Fix Your Gut

Ways-To-Fix-Your-Gut-Flora

We’ve seen how gut flora is responsible for keeping us healthy or making us sick. How can we make our gut stronger? Here are 9 ways to fix your gut flora!

  1. Reduce or cut your sugar intake: Sugar is one of the bad bacteria’s favorite foods!
  2. Avoid inflammatory foods: Some studies have shown that fats and oils ruin your health, but this research studied diets comprised largely of refined vegetable oils, such as soybean oil. On the other hand, grass-fed butter, organic coconut oil, and extra-virgin olive oil have been shown to promote a healthy gut flora and aid in weight loss!
  3. Eat a variety of healthy foods: Eating a wide range of healthy foods ensures we have a diverse microbe population, which is very important!
  4. Eat vegetables with every meal: If you can fill half your plate with vegetables and plant-based foods, your good bacteria will have plenty of fiber and nutrition to feast on and use to boost your health!
  5. Choose organic: Not only are GMOs and toxic pesticides are bad for our microbiome, they also affect the soil they’re grown in, and our gut bacteria and the bacteria in the soil are related.
  6. Eat prebiotic rich food: Sweet potatoes, asparagus, and other prebiotic foods feed the good guys!
  7. Incorporate fermented foods into your diet: Sauerkraut, kombucha, kefir, and pickles are all delicious fermented foods.
  8. Take prebiotics and probiotics: The use of pre- and probiotics feed the good bacteria that keep your gut healthy.
  9. Take steps to lower your stress: Try meditation, yoga, a walk or a jog, or partaking in your favorite hobby to reduce your stress. Studies have shown that stress can actually negatively affect the composition of your gut flora!

Takeaway

The state of your gut is responsible for both your physical and mental health. Luckily, even if your gut is in bad shape, it is easily remedied by following the nine steps listed above. The good bacteria are always ready to move back in, all you have to do is provide them with the right environment.

Click here to consult with a functional medicine doctor for a personal plan to improve your gut flora!

References:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5454980/

https://translational-medicine.biomedcentral.com/articles/10.1186/s12967-017-1175-y

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4566439/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4848870/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4940716/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4259177/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4425030/

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662178/

Health Benefits Of Potassium

Health Benefits Of Potassium

Health Benefits Of Potassium

By: Dr. Justin Marchegiani

Introduction to Potassium

Over the years we can see a major change in our food habits. While our ancestors were mainly dependent upon fresh fruits and vegetables, but in recent days most of us get inclined to choose ready-to-cook food items or easy to make food items to balance either fast or a sedentary lifestyle. This change of food habits may be a prime reason for inviting several non-communicable diseases like hypertension, cardiovascular disease, arthritis, osteoporosis, repetitive kidney stone formation etc. Fresh fruits, vegetables, and nuts are very good sources of Potassium.

Potassium is a well-known mineral that plays several vital roles in our body. Primarily, maintaining the fluid and electrolyte balance, maintaining the pH of the body fluids (the acidity or alkalinity of the body fluids depends upon pH), assisting in nerve signaling transportation to muscle tissues and uphold normal functioning.  According to the World Health Organization (WHO) recommendations, the adults should take at least 90 mmol (3510 mg) potassium every day. [1] However, recommendation for daily intake of potassium may vary country-wise; as in the United States, Canada, Bulgaria, and Republic of Korea recommends 120 mmol of potassium every day. [2] Hence, it is imperative to have a detailed knowledge about the role of potassium in our body.

Normal potassium level in blood

The normal limit of potassium is 3.6 to 5.2 mmol per liter of blood. An immediate medical attention may be required if you have lower than 2.5 mmol of potassium per liter of blood. Hypokalemia is the medical term to indicate a low level of potassium in the body. 

Symptoms of low level of potassium

Symptoms of low Level Potassium

The following are some symptoms associated with low potassium level:

  • Fatigue
  • Numbness
  • Palpitation
  • Abdominal cramp
  • Nausea and Vomiting
  • Constipation
  • Excessive sweating
  • Low blood pressure
  • Fainting
  • Depression
  • Confusion

If you frequently face any of the above symptoms then it is always advisable to go for a health checkup. 

Health Benefits of Potassium

Health Benefits of Potassium

Apart from the above conditions which may be controlled by maintaining a proper potassium level in the body, it also imparts various health benefits which can inspire you to maintain a healthy potassium level.

Controlling hypertension

Hypertension is a common health problem; almost one-third of Americans have hypertension. Hypertension usually does not provide any symptoms, but it is one of the major cause of stroke and cardiovascular diseases and kidney problems. Sufficient potassium intake can effectively control hypertension. An intake of less amount of potassium-containing diet can result in excretion of less amount of potassium through urine. This indicates electrolyte imbalance (imbalance of sodium-potassium ratio in the blood), which causes hypertension.  An adequate amount of potassium intake can maintain electrolyte balance and influence receptors, hormones and nervous system to dilate or expand blood vessels. Dilation of blood vessels reduces the extra pressure exerted by the blood in the wall and control hypertension.

Prevent stroke and other cardiovascular diseases

Research study provides the evidence that if you have potassium deficiency due to inadequate poor potassium diet, then your urine will definitely contain less amount of potassium. This will lead to over functioning of the heart and can cause a stroke because of increase blood pressure lowering effect. The potassium-rich fresh fruits and vegetables are also an adequate source of antioxidant. These antioxidants prevent cardiovascular diseases by scavenging or removing free radicals. 

Improve bone health

Osteoporosis is another most common condition, especially in women population. It is a disease which occurs when the bones in our body become weak and may break very easily (maybe from a fall or, maybe even due to sneezing in case of serious disease condition). The potassium therapy is a cost-effective treatment to improve your bone health and prevent osteoporosis. Potassium-containing diet is alkaline in nature and assists to maintain the pH of the blood and prevents bone tissue damage.

Calcium, the most important bone content can also be restored by consuming potassium-rich diet because potassium can decrease the calcium excretion through urine. A research study showed that 90mmol/day of potassium can able to decrease the parathyroid hormone activity and thus it prevents calcium loss from the bones. 

Prevent kidney stone formation

Pain due to kidney stones is unbearable; often causes problems during urination, like burning sensation, bladder discomfort and also induces or creates urinary tract infections. Potassium-containing diet is a simple remedy to the individual who suffers from repetitive kidney stone formation problems. Potassium reduces absorption of calcium in the gut wall. Potassium can do this, as it reduces phosphate retention by the kidneys. Human studies conducted in the U.S.A. showed that a potassium-rich diet can able to reduce the repeated incidence of kidney stone formation in both men and women. 

Low Potassium level negative for diabetic patient

Diabetes is a metabolic disorder. American Diabetes Association revealed that almost 15.7 million Americans are suffering from diabetes. Several human research reports stated that lower potassium level aggravates the diabetic complications by increasing BMI, and increasing waist size, while the fasting insulin level also gets increased. [6]

Sources of Potassium

Sources of Potassium

There are several easily available potassium-rich food sources are present in nature, which can easily increase the potassium level to combat potassium deficiency. If you opt for a suitable dietary measure, then it will be very economical and can save money to buy different potassium supplements.

Most interestingly, a calorie-rich diet contains more potassium. The below table mentions rank wise different dietary sources of potassium and their calorie value:

Dietary source or name of the Food Serving size (gm) Quantity of Potassium (mg) Present Energy (kcal)
Baked potato with flesh and skin A small sized potato (143) 738 128
Canned Prune Juice One cup (256) 707 182
Canned Carrot Juice One cup (236) 689 94
Tomato (paste) Quarter cup (65.5) 664 54
Cooked Green Beans Half cup (74.5) 654 19
Canned White Beans Half cup (90) 595 149
Canned Tomato Juice One Cup (243) 556 41
No fat and low fat containing Plain Yogurt Eight ounces (245) 531-579 127-132
Tomato Puree Half Cup (125) 549 48
Skinned Baked Sweet Potato One medium size (119) 542 103
Fresh Orange Juice One Cup (248) 496 112
Cooked yellowfin, Tuna Three ounces (57) 484 118
Banana One medium size (118) 422 105
Skimmed Milk One Cup (245) 382 83
Boiled parsnip Half Cup (80.5) 296 55
Boiled Green Peas Half Cup (82.5) 217 37
Boiled sweet yellow colored Corn Half Cup (79) 162 72
Boiled Cauliflower Half Cup (70) 89 14

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650509/


References

  1. http://www.bmj.com/content/346/bmj.f1378
  2. https://www.mayoclinic.org/symptoms/low-potassium/basics/definition/sym-20050632
  3. https://www.webmd.boots.com/a-to-z-guides/low-potassium-hypokalaemia
  4. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3650509/
  5. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963920/

The Cholesterol Myth

Cholesterol Myth

The Cholesterol Myth

By Dr. Justin Marchegiani

If you’ve only been told what the general public has been told about cholesterol and heart health, you probably believe cholesterol is one of the prime culprits behind heart disease. But do we have enough scientific support to prove this statement, or it is just another health myth that’s been blindly taken for true?

According to the WHO (World Health Organization), almost 20 million cardiovascular deaths occurred in 2015, making them responsible for about 30% of the global death rate. It is obvious that we need to take extra care to ensure the health of our hearts, but it is also our responsibility to properly investigate medical and dietary recommendations. The objective of this article is to guide you through this process and to help you understand the role cholesterol plays in keeping us healthy. After reading this article, you will have the knowledge to decide for yourself whether or not you want to restrict dietary cholesterol!

Introduction to Cholesterol

There is a much controversy among researchers who have been investigating cholesterol as a contributory factor towards heart diseases. Cholesterol actually has many beneficial roles, and there is insufficient evidence to support claims that high cholesterol is correlated to death due to cardiovascular issues.

  • There is cholesterol present in all fatty foods.
  • Cholesterol is necessary.
  • Dietary intake of cholesterol has negligible effect on plasma cholesterol level; as the liver eliminates excess cholesterol and maintain health plasma cholesterol level
  • Restricted diet and lifestyle measure cannot control hypercholesterolemia occurs due to hereditary or genetic reason.
  • Hypercholesterolemia can occur at any age, even children can also develop due to liver dysfunction.
  • Cholesterol consumed through food is unable to dissolve in blood.
  • Lipoproteins, comprised of lipid and protein molecules, act as a carrier in cholesterol transportation in the blood circulation.They are classified into two main groups: low density lipoproteins (LDL) and high density lipoproteins (HDL). LDL can be large and fluffy (and safe), or small and dense (and dangerous).
  • Large LDL particles are not harmful and do not play any part in plaque formation.
  • A case for saturated fat: Butter is more heart-healthy than margarine, as margarine creates small, dense LDL, whereas the saturated fat in butter converts the small, dense LDL into the large, fluffy (safe) LDL. Let the butter flow!

Click here to work with a functional medicine doctor to discover your cholesterol levels!

Cholesterol-Rich Diet: Dangerous or Not?

This is an important question to ask. The British Medical Journal (BMJ) conducted research which showed that lowering cholesterol levels by switching to a cholesterol-free diet could not reduce the cardiac diseases related death rate.

Dietary guidelines promote vegetable oil over saturated fat, and this is reflected in national spendings on vegetable oils. However, dietary saturated fat has been shown to reduce the chance of heart attacks, whereas vegetable oil may actually increase this risk. Other factors that may cause increased cholesterol levels in the blood include:

  • Family history, as this affects your genes and predisposition to certain genetic patterns.
  • Your lifestyle: stress levels and diet have a profound affect on not only your general health, but also on your gastrointestinal function.
  • In instances of leaky gut syndrome, gut permeability allows food particles and toxins to leak into the bloodstream, which leads to elevated cholesterol and triggers inflammation.

The Vital Nature of Cholesterol

Cholesterol is one of the primary constituents of cell membranes and plays a major role in the maintenance of normal human cellular physiology. Cholesterol takes part in protein interaction and in signaling systems inside the body. Steroid hormones and bile acid are actually composed of cholesterol!

Research conducted in the 1960s reported cholesterol has no impact in the formation of atherosclerotic plaque. When the British Heart Foundation showed their skepticism, scientists in New York re-evaluated these findings by using new technology. This more advanced technology turned up the same results: increased cholesterol levels, specifically LDL-cholesterol, does not cause plaque progression. This is made obvious due to the fact that cholesterol lowering drugs are unable to lower the risk of death for patients who take these drugs. What’s more, according to the BMJ Open journal publication, almost 92% individuals with high cholesterol level have longer life span!

A Case For Dietary Cholesterol

A Case For Dietary Cholesterol

In 1960, the American Heart Association guidelines made the recommendation to stop eating eggs due to their high saturated fat content. This started the dietary trend of restricting egg consumption in an attempt to be heart-healthy. However, research conducted by Harvard involving more than 80,000 female nurses showed that eating eggs daily does not increase the risk of cardiac disease. It’s important to keep an open mind, seeking out evidence-based research rather than blindly trusting paid-for promotional gimmicks. The “fear” of eggs is starting to reverse, as a recent dietary recommendation published by U.S. Dietary Guidelines reported that egg yolks is an important source of protein. A good step forward!

A survey conducted in South Carolina also support a saturated-animal-fat rich diet, which includes foods such as meat, eggs, whole milk, butter, cheese, and bacon, as their research proved there is no correlation between blood cholesterol levels and dietary fat intake ratio.

The Lancet publications are one of the world’s oldest and best known general medical journals. One Lancet publication stated that 74% of plaque formation in the arteries is associated with unsaturated fat sources, including canola oil. Attempting to reduce your risk of cardiovascular issues by cutting natural sources of saturated fat (like butter) is not where our focus should be, as this study proves that unsaturated fats are the real culprit destroying our health.

Drugs to Lower Cholesterol: More Dangerous than Cholesterol Itself?

Statin drugs are one of the established pharmaceutical brand medications for lowering cholesterol levels to “reduce the risk of heart disease.” Statin drugs are frequently prescribed to patients at risk for cardiovascular problems, but their effectiveness is not proven, and the list of side effects is long.

Continuous intake of statin drugs can cause fatigue since energy production become reduced. These medications increase the risk of blood clogging up the arteries (atherosclerosis) and heart failure by decreasing vitamin K2 absorption. Side effects also include diabetes, cancer, musculoskeletal disorders, neurodegenerative disease, and cataracts.

The effectiveness of statin medications preventing heart attacks or death from heart attacks is negligible, as multiple studies have revealed that statin therapy can only produce a 0.6% risk reduction of having a heart attack when compared to rates of patients who did not take statin drugs.

How to Reduce Your Risk of Heart Disease

How To Reduce Risk Of Heart Disease

So we see that not only do statin drugs not protect against cardiovascular disease, they also come with a long list of dangerous side effects. So what can you do to lower your risk? Here are some tips to live a healthy life:

  • Replace simple carbohydrates with complex carbohydrates (whole grains) and fibers: Refined grains, such as white bread, pasta, flour, and white rice are high in glucose. Glucose is a simple carbohydrate with a high glycemic index, which can lead to insulin resistance. Increased insulin can also convert fat into trans fat, which causes inflammation and is associated with blocked arteries, cardiac disease, and cancer.
  • Cut the sugar! Sugar leads to all sorts of illnesses, including an increased risk of heart disease. Start by ditching the soda (one can has over twice the recommended daily maximum amount of sugar), and from there continue to make healthier swaps.
  • Be active! Take part in a sport, go for a job, lift some weights, swim, dance… Exercise lowers the risk of heart disease and boosts your mood!
  • You’re better off swapping the canola oil for coconut oil (a healthy source of saturated fat)!

Click here for a professional health consultation and start feeling better today!

References:

https://www.ncbi.nlm.nih.gov/books/NBK45688/

https://www.bhf.org.uk/heart-matters-magazine/news/behind-the-headlines/cholesterol-and-statins

https://www.ncbi.nlm.nih.gov/books/NBK351/

https://www.ncbi.nlm.nih.gov/pubmed/18615352

https://www.hsph.harvard.edu/nutritionsource/cholesterol/

http://www.ravnskov.nu/2015/12/27/myth-6/

http://ajcn.nutrition.org/content/78/3/544S.full

https://www.ncbi.nlm.nih.gov/pubmed/18609060

https://www.ncbi.nlm.nih.gov/pubmed/12507667?

How Sugar Feeds Illness

 How Sugar Feeds Illness

How Sugar Feeds Illness

By Dr. Justin Marchegiani

America takes first place… as the top consumer of dietary sugar in the world. Our sugar consumption is a major player behind the skyrocketing rates of chronic diseases like diabetes, obesity, and cancer. The average American now consumes an average of 130 grams of sugar per dayfor reference, the daily recommendation for women is a maximum of 20 grams a day! This is more than just sad: it’s dangerous. Today we are going to outline some of the effects of sugar on our immediate and long-term health.

What is Sugar?

What is Sugar

This might seem obvious, but food producers are getting craftier with their labeling as they realize more and more people are making the choice to eat healthier. Sugar goes by many names, with new ones popping up all the time. Some sugars are natural, most are processed, and more and more are being created in labs. Here are just a few names to look out for on product labels:

  • Agave
  • Brown sugar
  • Corn sweetener
  • Corn syrup
  • Fruit juice concentrates
  • High fructose corn syrup
  • Honey (raw, pasteurized)
  • Invert sugar
  • Malt sugar
  • Molasses
  • Raw sugar
  • Sugar
  • Sugar molecules ending in “-ose” (dextrose, fructose, glucose, lactose, maltose, sucrose)
  • Syrup

Click here to consult with a functional medicine doctor and discuss underlying health issues preventing you from living your best life!

What About Fruit?

Yes, fruit technically contains sugar, in the form of fructose. However, there is a big difference between enjoying a piece of fruit as an after-dinner treat, versus having orange juice with breakfast and fruit juices as your beverage of choice throughout the day. Studies have shown that eating fruit whole can lower risk of developing type 2 diabetes, drinking fruit actually increases your risk! The fiber you get from eating fruit whole slows the absorption of the sugar and keeps the glycemic index low. Plus, it takes a lot more squeezed fruit to fill a glass than you could possibly eat in a serving, meaning you’re consuming way more sugar than you realize!

The Effects of Sugar

The Effects Of Sugar

Consuming large quantities of sugar has been linked to an increased risk of a variety of chronic diseases including obesity, cardiovascular disease, diabetes and non-alcoholic fatty liver disease (NAFLD) as well as cognitive decline and even some cancers!

There are also many health issues caused by sugar that aren’t as talked about:

Sugar depletes the body of critical electrolytes, antioxidants, and minerals, which leads to cell death, muscle spasms, insulin resistance, and other health defects. Its effects on the immune system leave you prone to getting sick more often and more severely.

Sugar feeds bacteria and parasites, like yeast and Candida. It also depletes the body of good gut bacteria, promoting Leaky Gut and other gut infections. Chronic pain, vision problems, and even wrinkles can be worsened by sugar!

Sugar causes chronic inflammation in the body, and inflammation is said to be the root cause of almost all disease.

How Sugar Feeds Cancer

Sugar consumption has been proved to feed cancer cells and speed up the growth of tumors. Too much sugar consumption causes insulin resistance, as well as a specific protein to be released from your pancreas. This protein causes your cells to replicate and become immortal, which is how pre-cancerous cells can begin to take over.

Cancer cells prefer glucose over oxygen, but our mitochondria can’t use the glucose as energy. White blood cells are our immune system’s soldiers, and need vitamin C to function properly. A cancer patient needs lots of healthy white blood cells to fight the disease, however, sugar blocks the absorption of vitamin C in our bloodstream, weakening our immune system.

In summary, sugar causes cancer cells to reproduce and thrive, and blocks the mechanisms that would slow down or kill cancer cells and tumors.

Takeaway

Sugar addiction runs deep, and can be hard to kick. Stay tuned for Dr. J’s thoughts on artificial sweeteners, approaches to beating sugar addiction, and healthy alternatives for sugar.

Click here to talk to a functional medicine doctor about staying healthy this holiday season!

Natural Solutions For Dandruff Fungal Overgrowth – Dr. J Live Podcast #162

Dr. Justin Marchegiani and Evan Brand talk about dandruff in today’s podcast. Learn what causes it and explore other possible underlying health conditions like gut infections involving bacteria, yeast, fungus or parasites.

Gain an understanding on how functional medicine practitioners approach this kind of problem including their clinical strategies and the testing involved.  Get very helpful information regarding the products that they have found effective to address dandruff and the supplements they recommend to improve health conditions related to dandruff issues.

In this episode, we cover:

06:32   Antibiotics and Dandruff

07:27   Fungus and Refined Sugar

14:25   Birth Control Pills Effect and Dandruff

23:03   Hair Loss and Thrush Issues

32:16   Glutamine and Leaky Gut

Just In Health iTunes

Just In Health YouTube

Evan Brand: Weekend was great. Life is good except for the weather—rainy, cloudy cool. Fall is here officially, but what can you do?

Dr. Justin Marchegiani: Very cool. My wife and I brought our new baby to his first wedding. That was pretty exciting. First wedding with the new one was fun and he did a great job.

Evan Brand: Oh, good. Ain’t it great when you go out on public and the baby is good, isn’t that great?

Dr. Justin Marchegiani: Yeah. Totally. How’s your baby doing?

Evan Brand: Oh, she’s great. She’s actually— she’s got her molars coming in.

Dr. Justin Marchegiani: Oh, wow!

Evan Brand: So she’s very incessantly crying this morning. Uh— but wife texted me and said the baby knocked out. So naptime is a good time. That’s great, man. Very cool. Well, we chatted kinda in our early part of the show talking about what we’re gonna talk about today, really. And we kinda discuss that dandruff is a big issue that’s been coming up in our clinical practice. We want to talk about kinda what is and just some of the clinical strategies that we utilize to approach it and to help address it from a root cause functional medicine perspective.

Evan Brand: Yeah. Something I think we should hit on first is what’s the conventional approach is? Is it dermatologist that people are getting refer to? Like what’s the rabbit hole would you say that people end up on with the dandruff problem?

Dr. Justin Marchegiani: So dandruff typically uses excessive shedding of kinda the skin on the scalp. And it tends to be fungal driven. Of course, there are natural diet things that help, right? Good fats, good proteins, like the digestive, the hydration component. All those things are important, but the infection component is really important because you can have the diet stuff all dialed in and that may not be enough to get rid of that infection component. And sometimes the— the fungal overgrowth that—that’s there could be there from a deeper infection. It could be there from H. pylori or blasto or deeper parasite infection. So, it’s important we keep our eye on what could be there in the scalp area, but also what other bigger infections could be promoting that overgrowth.

Evan Brand: Yup. So, if you go to conventional doc and you just happened to bring up dandruff, what are they going to do? You think they’ll just refer you out to a dermatologist in then they’ll give you some steroids for it?  What would the conventional approach be? That way we have something to contrast it to our functional medicine approach.

Dr. Justin Marchegiani: Yeah. So your conventional approach is gonna be head and shoulders or sell some blow. That’s gonna be the general conventional approach. They may give you uh—a uh—you know, systemic antifungal medication that they see other kinds of things happening there. That’s gonna be the general consensus.

Evan Brand: Yeah.

Dr. Justin Marchegiani: So the first thing that we’re gonna look at is we would probably lean more towards a anti-fungal kind of shampoo that’s herbally-based like tea tree or lavender or uhm—neem. These are some of the really good antifungal shampoos that are out. We’ll put some of the links below couple of the ones that I like are Art Naturals and Purely Northwest. We’ll put some links below here, so people can access them. We—I use those in my clinic a lot. You can also just get some pure you know, apple cider vinegar. You can mix a little bit of coconut oil. You can even do a little bit a tea tree and put it straight and kind just gonna do a little scalp massage and get right there in the scalp. That can be helpful, too. Uhm—but  some other shampoos that are out there that already to go. So that’s another good option for you. Just, if you don’t want to have to deal that.

Evan Brand: Cool. So let’s talk about testing. I mean this is always our philosophy. “You’ve got to test, don’t guess.” If you’ve got a fungal issue, we talked about parasites. So we want to look into the gut and in the organic acids testing. Wouldn’t you say that be an important one for this, too?

Dr. Justin Marchegiani: Yeah. I like the organic acids because because you can kinda look at fungus that may be more systemic. So when we look at a gut test, we may see various species of fungus in the gut. We may see Candida. We may see geotrichum yeast. We may see other types of Candida species. These are different species of yeast. And again, yeast is like the big umbrella. Fungus is the big umbrella and then we have some species of yeast there kinda under that big umbrella of fungus. So fungus is the big umbrella, yeast is the— the smaller kind of umbrella. And again,s mold like different molds that you may see like aflatoxin mold or ochre toxin. These different compounds are also kinda under that fungus mold umbrella as well, right?
Evan Brand: Yup.

Dr. Justin Marchegiani: So getting to your question—Those are some of the big ones that you may see. Now, the benefit of the organic acid test is we have some markers that are more systemic base. So we have the D-rabanose. It’s an interesting marker that looks at fungal overgrowth from a systemic perspective. So, sometimes we see people to get the stool test back and they’re maybe okay from a fungal perspective, but when we look at the organic acid urine, we may see that the D-rabanose is on the higher side which tells us there maybe some kinda fungal thing going on at a systemic level and sometimes we may see it systemically but not on the gut. So that’s a good marker, too, for treatment.

Evan Brand: Yep, cool. Yes, so, Justin and I, between us both, we run thousands and thousands and thousands of stool and organic acids testing. I would say, Justin, tell me if your assumption is different. Nine out of every 10 people have a yeast and/or a fungal problem. Whether it’s to the level which can cause extreme issues or not. Maybe it’s not nine out of 10 that have an extreme problem, but someone somewhere, nine out of 10 is gonna pop up with something that needs to be addressed in that category

Dr. Justin Marchegiani: Yeah. 100%. I think there’s some –there’s always some gut component. I would say the majority is a gut component. And most people with a gut component, uh—yeast is gonna be present. I find that yeast as the primary issue isn’t more common—it’s—actually less common, I should say. Where it’s more common is there’s a deeper, infection like a parasite or bacterial infection that’s of a higher level.

Evan Brand: Yeah.

Dr. Justin Marchegiani: And yeast is kinda there, kinda like you see these sharks and you see these underlings that kinda suck to the shark’s belly.

Evan Brand: Yup, right.

Dr. Justin Marchegiani: They’re kinda like that. They’re just there as the underling and you get these bigger, stronger kind of critter that is the primary focus.

Evan Brand: Oh, by the way, I don’t know if this is true, I heard from a client of mine last week, supposedly, diagnostic solutions is coming out with a new panel that can be added to the GI-MAP where we can actually test for worms including pin worms.

Dr. Justin Marchegiani: That’s awesome! I’m really excited. Worms are definitely a concern. I know we’ve talked about, you know, we use –we add in worm wood. We added mimosa pudica, various herbs like that to help with a lot of these worms as well.

Evan Brand: Yeah. So, that’s true. We’re gonna have some really good extra clinical nuggets in our hand.

Dr. Justin Marchegiani: Hundred percent.

Evan Brand: So—I wanted—I wanted to mention antibiotics. So, somebody does have dandruff and we could also convey that message to other issues with the hair, the skin, the nails.

Dr. Justin Marchegiani: Uh-hmm.

Evan Brand: There’s probably a history of like a urinary tract infection, right? So like these yeast and fungus that you’re talking about. If that’s affecting the vaginal area for a female and they get put on some type of natural antifungal or probably a conventional anti fungal. That stuff’s gonna come back with a vengeance. They may end up doing antibiotics therapy, too. And that’s not good. That’s gonna create a lot of room for the yeast and fungus to overgrow and  all of a sudden, you’ve got the clean up crew that has to come post-antibiotics.

Dr. Justin Marchegiani: Hundred percent.

Evan Brand: We’re not big fans. Like if you can avoid antibiotics, if your life is not in danger, then you could probably go ahead and say skip them and go to the natural remedies instead.

Dr. Justin Marchegiani: A hundred percent. So of course, the big thing when we deal with any type of fungus is really cutting out refined sugar. So, if we could look at our carbohydrates, we kinda draw a line down the middle. We have like real food carbohydrates on one side of the fence, and then we have refined sugar carbohydrate with extra added sugar to the carbs on the other side. So, basically, draw that line, anything that’s refined sugar, we throw out, and then the left side, I kinda break it down into starchy, non –starchy, okay? So, starchy being like sweet potatoes, squash, white potatoes. Non-starchy could be our veggies, uh—broccolis, brussel sprouts cauliflower, kale. Those are our non-starchy. And then basically, we have our high sugar fruit and our low sugar fruit.  High sugar fruit are gonna be more tropical things—bananas, pineapples, mangoes, right? Those kind of things. Then we have our lower sugar fruits— berries green apple, grape fruit passion fruit. Those kind of things. So we try, number one, stay on the non-starchy carbs primarily. And the low sugar fruits. So typically, 1 to 2  servings a day even on an anti-fungal approach is gonna be okay. Some people they go to the excessive and cut everything out but there’s some clinical evidence that these fungal critters may go into the spore-like state where they’re now kinda in  hibernation mode. It may make it harder to kill them. So, we’ll actually have 1 to 2 servings of fruit in there. We may even actually up the carbs even more during the killing to bate them out. We want to wake up that bear so it’s not hiding in its cave  all winter, uh—so we can hunt them down, so to speak.

Evan Brand: That’s a great point.  So if a ketogenic— if a ketogenic diet has been the norm for someone, we may need to bump up carbs a bit, maybe add a little bit of fruit back. And there’s been a lot of demonizing of fruit lately, which I’m just not really a fan of that. I think there’s a  lot of value there.

Dr. Justin Marchegiani: Again, it’s all individual. If you’re super over weight, you have  a lot of markers for insulin resistance, your  waist size is greater than 40inches for male, you know, up 20 pounds too much weight on there, then, yeah, that may make more sense to limit it or at least focus on the lower glycemic, low sugar variety, right? Low fructose variety. Maybe  keep  that fructose below 15g a day. That makes sense. But if you’re pretty active and pretty healthy weight, I’m fine with it. Hand—couple of handfuls about a day, that’s not a problem.

Evan Brand: Yup, good. So you mention the diet peace, now, some talk about diet as if he could cure you of these problems. I mean, I don’t  really agree there where if you just follow this Candida diet, all of a sudden your problems are going to go away.

Dr. Justin Marchegiani: I think if someone is like, you know, they’re kinda like dipping their toe in the functional medicine field like, “Is this worth it?” Well, just start with the diet stuff and see how much you get accomplished with that. If someone is having a lot of refined sugar and a lot of refined carbohydrate, right? Remember that line I drew? Refined carbs and then whole food carbs? If they’re having a lot on this side and they cut that out, they may see a significant improvement, which is great. And they may cut the grains out as well, which is great. But uhm—that maybe that last 20 or 30%. Or if there’s a deeper infection, uhm—that will have to be removed as well. So if it’s purely a fungal overgrowth that you may see a good improvement, but there may be some stuff still lingering. If that’s the case, then we got to dig deeper. Put on our clinical hats and you wanna definitely reach out to someone like myself or you, Evan.

 Evan Brand: Yeah. Well said. I guess my point—I wasn’t trying to pass the diet piece. I guess my point is that a lot of people sell these books, promoting certain diets as if you can magically eradicate all of your gut problems. For me I got maybe 80% better so I dealt with IBS for probably 10 years, maybe even 15years. I mean, I had always had irritable bowel problems. Once my diet was better, my gut problems were there, but then when you first took a look at me, you said, “Evan, you’ve got parasites. And that’s something that no matter how much kale and broccoli I ate, I wasn’t going to get rid of parasites.

Dr. Justin Marchegiani: Or grass-fed meats. Yeah. Exactly. I get that. So, we’re kinda biased because we see a lot of people that already come to us, they got their diet on track and we got to dig  deeper on top of that. So, I get where you’re coming from, for sure.

Evan Brand: Yeah. But the low hanging fruit that is the diet. And then we—we’ve, you know, Justin and I often have people that come to us that have been doing like a Paleo template or even like uh—autoimmune Paleo and they’re still sick and that’s where you say, “Okay, good. You’ve got the diet in place. It has to be in place, perfect.” Now, let’s dig deeper and that’s where we gonna find this other stuff.

Dr. Justin Marchegiani: Hundred percent. So we hit the uh—we hit the fungal component of dandruff. We talked about the excessive shedding of the skin on the scalp. You know, a lot of babies have it. It’s called cradle cap or seborrhea dermatitis, tends to be fungal-based. Again, with my kiddo, or just really giving just real, good-quality breastmilk, but also what the mom eats has a huge effect on the breast milk.

So my wife has kinda have a good Paleo template, really on point. We give our kid probiotics as well. He gets the infant strain probiotic. I know your daughter did the same thing as well, which helps a lot, too. And surprisingly, our baby’s had you know, zero acid reflux, zero spit up. So I think that that’s really made a big difference as well.

Evan Brand: Cool. That’s awesome. Yeah. So mom’s listening, this could apply to babies, too. Now, do you have any evidence on this? Like a mom passing a yeast or a fungus overgrowth to the baby via breastmilk? I’ve heard that was Lyme’s disease and co-infections, you know, the spirochetes can pass through the breast milk but I just wonder about you know, the yeast. Could you pass a yeast through the breastmilk?

Dr. Justin Marchegiani: Well, that may or may not be the case. I’m not really sure. There may be some data on that. Uh—my biggest concern is a lot of the infants that are gonna be fed formula, if you look at a lot of the ingredients, it’s about 50% high fructose corn syrup.

Evan Brand: Oh, God.

Dr. Justin Marchegiani: If you look at the amount of sugar that’s in a lot of these uhm—formulas, it’s the same amount that’s in a Coke.

Evan Brand: Yup.

Dr. Justin Marchegiani: You just gotta be careful because that’s not really the best thing for your child. And then a lot of it is gonna be GMO, too. And there’s evidence of uh— Mercury on getting into a lot of these high fructose compounds due to the extraction process. That’s not good either.

Evan Brand: Wow. So I’ve talked with a couple practitioners who do like a microscope—

Dr. Justin Marchegiani: Uh-hmm.

Evan Brand: When you look at the blood and they’ve seen little—little balls of yeast basically in the serum of the blood. So I just wonder, “Huh, wonder if any of that actually gets into the system where— where mom pass it to the baby or not.” Well, I have to keep asking, keep digging. That is just my curiosity, but—

Dr. Justin Marchegiani: I think it’s a really great question here. And I’ve I think clinically, it makes sense. I see a lot of women that have poor gut issues and their child can get it.  You know, they’ll get thrush with that white coating, so to speak. And they’ll get kind of a yeast issue where they get a lot of kind of a diaper rash stuff and that can happen as well. Like with our child, we’ve had no real yeast issues not even any diaper rash. We just kinda—like a couple of times, my wife will put a little bit of coconut oil there. We have some natural stuff. Yeah, we put there. But outside of that, he’s—you know, my son Aidan has been doing great on that side of the fence.

Evan Brand: That’s great. All right, so we hit the diet piece, we talked about antibiotics as a potential problem leading up to this. I would say birth control pills could be a factor, too. I’ve have had a lot of women— I don’t know the exact correlation or causation. I don’t know if that’s doing something with progesterone and estrogen that—that’s causing the dandruff for what it is. Do you have a take on that of why  birth control pills could be a factor?

Dr. Justin Marchegiani: Yeah. Birth control pills have an effect of alkalizing. So we can alkalize the urinary track. It has effect in alkalizing the guts and fungus likes to be more in an alkaline environment. And now everyone’s like “alkalize your diet” right? Well, a lot of these bacteria and we’ll just say fungus’s and bacteria, they like more alkaline environments. If you look at what probiotics do, probiotics actually add acidic load to the intestines. Like if you look at acidophilus, it literally translates to acid loving or acid producing. If you look at a lot of the really good fermentable drinks, a lot of them are very high in various acids, whether it’s glucuronic acid or uhm—

Evan Brand: Acetic acid.

Dr. Justin Marchegiani: Acetic acid, which is the main acid in apple cider vinegar and it’s not a surprise that acids like apple cider vinegar are used to treat fungal issues in the hair or they’re used to treat UTI issues as well. People will then utilize the Apple cider vinegar before meal to help with digestion and also acidify the urinary tract, too. So, a lot of these things are very helpful to decrease the critters and it changes the environment in the gut. So, good probiotics actually spit out more CO2, right? They spit out more of these really good acids to help get the gut into an environment PH wise with these critters can’t thrive, so to speak.

Evan Brand: Ahh. Okay, got it. Yes. So birth control pills, the antibiotics, maybe the prescription Diflucan’s or other prescription antifungals that you could’ve been on before making these strains more resistant. We talked about the sugar in the diet we talked about the gun infections, looking into those for bacteria and yeast fungus, parasites, getting your gut check with functional testing, not conventional testing. We talked about getting the urine organic acids for looking into the yeast and measuring it that way because stool test often gives us a false negative.

Dr. Justin Marchegiani: We may even look at blood, too. We may look at candida antibodies like IgA, IgG, IgM. We may see those on the higher side, which could just mean there’s more of a systemic issue. And it’s nice to know because if we don’t have any gut stuff going on or we don’t even see any organic acids stuff, you know, typically, you’ll see some organic acid. You’ll see the D-arabinose there.

Evan Brand: Yeah. So what do you say to a person when they say, “Oh, Justin, can I just go buy a bunch of herbs and just start randomly throwing stuff from the kitchen sink at this problem and see if it works?”

Dr. Justin Marchegiani: Well, the bigger issue is most people that have these symptoms, they have a whole bunch of other things, too. It’s very rare that you’re like, “Oh, my only chief issue is dandruff.” Or some kind of fungal issue, right? It’s mood, energy, sleep. If you’re female, there’s probably some cycle imbalances, whether it’s menstruation issues or mood issues or breast tenderness, back pain. Whatever’s happening there and then you have this. So there’s a constellation of the different things happening. And body systems, they function and dysfunction together. So, imagine a beautiful orchestra going, right? And one instrument starts going off. Let’s call that one instrument our fungal overgrowth or uhm— our scalp kind of a dandruff issue, right? That’s our one symptom. That’s our one imbalance. Well, it doesn’t take long before the rest of the orchestra starts singing out of tune as well.

Evan Brand: Yup.

Dr. Justin Marchegiani: And that’s what I’m referring to when we talk about the other hormonal issues that go out of balance. And then when we start having gut issues, then we can start having more leaky gut, which then can create more immune stress, then we can have more malabsorption and low stomach acid and enzymes and nutrient deficiencies, which then affect neurotransmitters and other hormone pathways. So you can see how this thing can really spiral out of control pretty fast. So, that’s why it’s good always digging deeper to really get a good body system audit of all the other things that are happening.

Evan Brand: Yup. Well said. I’m so glad you—you said it so eloquently. I did a rant at the end of my podcast that I put up last week and I just told people like, “Look, please, don’t wait until you hit rock bottom. Don’t wait until every body system is falling apart and then you reach out.” Like you and I work with those complex cases all the time. But if you’ve got one thing like it’s anxiety or little bit of depression or little bitt of gut issues or little bit of skin issues, it’s so much better to start getting tested and start digging deep then, as opposed to waiting until you’re symptoms list is 20 pages long. You’ve been suffering for 20 years, then you hit rock bottom, then you decide you want to get better. I’ll tell you, it will save people a lot of money and a lot of suffering if once you see these problems a little tip the iceberg poking out, address it, then don’t wait until like you said you’ve got anxiety, depression, PMS, irritability, mood swings, rage, poor sleep and dandruff to top it all off.

Dr. Justin Marchegiani: Hundred percent.

Evan Brand: Please. And that’s not even to benefit us. It’s to benefit you. You know, we’ve been so booked up that we aren’t necessarily begging you, “Hey, please come see us.” It’s not like that. It’s the fact that, “Hey, look, I just want to save you some suffering and save you some time.” Justin and I came from our own health journeys as well and if we could just give you one piece of advice and maybe I’m not speaking for him, so I’ll let Justin give his— his feedback, too. But If I could  say one thing, it would be if you’ve got a weird symptom, there’s probably some other stuff going on that you just have to find and fix.

Dr. Justin Marchegiani: Hundred percent.

Evan Brand: Like me, I had to wait until I’d lost about 25 pounds. I had terrible sleep. I woke up, I wasn’t feeling rested. I had a lot of stress. I had some anxiety problems even to the point of a panic attack. I called Justin up one day, “man, my heart’s beating out of my chest. I can’t stop my heart.” You’re like, “Well, how much stress do you got going on? I was like, “ a lot” And he’s like, “how are you sleeping?” I’m like, “haven’t been sleeping very well” and then he’s like, “what’s going on with your gut?” and I was like, “Oh my Lord, every body system is affected” My gut has been affected, my brain, my stress response is broken. I was like, “this ain’t even me, I’m even an anxious person. What’s going on?” And you go, “Oh, it’s parasites, Evan.” So, for me, I had to learn the hard way. I had to wait until my symptoms piled up so much that I was falling apart to then fix it.

Dr. Justin Marchegiani: Hundred percent agreed. I think we’re at that the point in our careers where we realize that there’s probably uh— more people out there that we see online with the you know, the millions of downloads we get every few months, that were not gonna be able to help anyone— everyone, so to speak. And there’s just too many people out there to help that— you know, we really want to put as much free content out there and if we can just get most of the people to just apply the free stuff, that is going to be huge. And we’re gonna make a huge difference in the world just by itself.

Evan Brand: Yup.

Dr. Justin Marchegiani: I think we’re really just getting really good actionable information and I think the key thing I want to push to everyone listening, if you can walk away with just one action item, “Hey, I’m gonna do this.” or “I’m gonna add this component.” or “I’m gonna add this diet shift or this lifestyle change, or this supplement change” I think that you’re gonna make yourself better and healthier after every podcast.

Evan Brand: Agreed. Cool. Do you want to hit some questions for a few minutes?

Dr. Justin Marchegiani: Yeah. We’ve got some questions.

Evan Brand: Okay, cool.

Dr. Justin Marchegiani: Everyone writing questions, if you can kinda keep the questions framed towards the conversation, I mean, you know, you can kinda do a little politician pivot where you’re like, “Hey, dandruff” and then you’re on adrenals, right? We could kinda do that, so to speak. But I’m just trying to keep it connected to what we’re talking about as possible. If it’s so disconnected, we’re just gonna have to skip over the question.

Evan Brand: Yup, yup. Well said. Okay. Yes. So a lot of those were like off-subject questions. Let’s see.

Dr. Justin Marchegiani: I got one here about—let me see, I’ve got Gerald’s question here. Gerald was on my G.I. Clear 2, positive for H. pylori. I feel like it’s returned. If add Masika to the G.I. Clear 2 what dose should I take per day? Typically, two caps TID, two caps, three times a day and we need to retest, Gerald. Make sure the infection is gone. Make sure there’s no residual infections. We want to look a little bit deeper to at your partner or any dogs or pets in the house. Uhm— partner for sure is the easy one because that can, you know, you can go get that reinfected back and forth. So we need you to retest and then do GI Clear2 and the pure Masika, 2 caps TID and get that retested.

Evan Brand: Well said. Yeah. I had that a few weeks ago. A lady, she said, “I feel like my—my gut’s backtracked. I got off your herb. So, what’s going on?” and I said, “Well, now it’s time to test your partner. And sure enough, there is the H. pylori.

Dr. Justin Marchegiani: Yup.

Evan Brand: That’s why she’s been getting re-infected. It took three rounds to get rid of it.

Dr. Justin Marchegiani: Totally.

Evan Brand: Alright, let’s go over to the next one here. There was one from Ovi. We’ll call it uh—I don’t know how to pronounce that full name. “Any tips on reducing hair loss and thrush when coming off of HRT as a female?”

Dr. Justin Marchegiani: So— that would be helpful to know. I mean, imagine, I’m just coming guessing this is menopausal female, okay? So, you know 53-54 and up. So depending on kinda where the hormonal imbalance is, it’d be good to know if there is an estrogen dominance present or if we’re just having low estrogen and low progesterone and everything’s kinda in the tank. So, typically, when I think hair loss, though, I’m leaning more on the thyroid side. So, I’d want to know where the female hormones are at or if you’re cycling or not. So, if you want to comment on that, that’d be helpful. Uh— number two, really looking at the thyroid component because the thyroid has a huge effect on the hair follicles, stimulating the hair follicle to grow.  And then number three is the gut component because that’s where we digest and break down a lot of the nutrients and amino acids and fatty acids that become the building blocks for our hair. So I want to look at those three places first.

Evan Brand: Well said. So I’d also add on looking at ferritin levels, too.

Dr. Justin Marchegiani: Yeah.

Evan Brand: See if there’s some type of anemia problem. You hit the thyroid so in—

Dr. Justin Marchegiani: And when I say thyroid, though, that includes all that consolation because iron is very important for making thyroid hormone, so if you have a history, if it’s menopausal female and she’s not vegetarian or vegan, doesn’t have a history of endometriosis or fibroids or excessive menses, it’s probably not an iron issue.

Evan Brand: Good. Good. And then when you talk about the thyroids, too, so this is also including the antibody. So make it sure that there’s no Hashimoto’s at play coz we see that a lot. Justin and I find that many people with autoimmune thyroid, the hair, like nine times out of 10 it’s a problem.

Dr. Justin Marchegiani: Yup. Exactly. We’ll add in collagen peptides, too. Just this collagen is uh—it’s just great. It’s a great building block and then if it’s in peptide form, it’s already super easy to digest. So, give a little plug for my Tru Collagen on that one.

Evan Brand: Yeah. Check it out. Alright. Gerald had a follow-up question for second round of H. pylori eradication, should it be a 30 day protocol or 60 days?

Dr. Justin Marchegiani: Yeah. Typically, a minimum 30. You can’t go wrong with just a 30. It just depends on what other infections were present along with that, but if it’s just the H. pylori, let’s say 30—30 to 45 is typically good.

Evan Brand: Yup. Nice. Alright. Mossimo had a question here, “Are sustained-release essential oils and herbs necessary as opposed to the liquid oil taken internally? It’s kind of a confusing question. I didn’t know there was such thing as a sustained-release essential oil, but what were talking about for this conversation would’ve been like a topical. So like Justin mentioned about those brands of the tea tree oil shampoos and such—

Dr. Justin Marchegiani: Yeah.

Evan Brand:  That would just be a couple of drops on the scalp. Use some type of Jojoba or avocado or coconut oil.

Dr. Justin Marchegiani: Yeah.

Evan Brand: And try to dilute that so it doesn’t burn your scalp.

Dr. Justin Marchegiani: Totally. In my line, we have GI Clear5, which is an emulsified form of oregano. That is more enterically coated. So it does open up more in the small intestine than the stomach. A lot of the fungal issues tend to be more on the stomach. I’m sorry—

Evan Brand: Oh, yeah.

Dr. Justin Marchegiani: It tends to be more in the small intestine. H. pylori more in the stomach. Evan Brand: Yeah. I forgot about the—the oregano oils.

Dr. Justin Marchegiani: Yes.

Evan Brand: I guess when I read essential oils, I was thinking just like your standard oils that you diffuse.

Dr. Justin Marchegiani: That’s why I’d like to have some of my, you know, oils or some of my herbs taken on an empty stomach just so it can get fully out of the stomach into the small intestine where it can really help. It and really help can be little more effective.

Evan Brand: Yeah. Alright. So, Samuel had a question. “What’s your take on taking CBD with no THC for inflammation? I take it for the first time and noticed a huge difference in relaxation.” I’ll hit this one.

Dr. Justin Marchegiani: Yeah.

Evan Brand: I’m a huge fan. I just posted a YouTube video. If you haven’t checked it out, look it up, Samuel. I went to uh—a hemp form here in Kentucky one of the very few hemp programs that has been approved by the state government. And the guys making super high quality CBD and the guy is— so he used it on his son who is having hundreds of seizures per month and now the kid is like 12 years old and hasn’t had seizures in years just from CBD no THC. I think the THC does have benefit. I hope that there’s a couple of bills that are trying to get through for 2018. I hope we can federally just decriminalize cannabis across the board because I have talked with people, especially in the pain department, where when they add a little bit it of THC in, all the sudden their fibromyalgia or chronic pain does get better, which isn’t achieved just by the CBD by itself. So I think both would be awesome.

Dr. Justin Marchegiani: Yeah. I’m not a huge fan of the THC side uhm— I think it can have some really good benefits if you’re going through cancer treatment and have extreme nausea and/or extreme pain and the CBD is not helping enough. I think it can be helpful like if we’re choosing you know, THC over chronic dose of the pain medication or opiate or like a lot ibuprofen, I will definitely reach for the THC component you know, over—over the rest. My biggest thing is just uhm— number one, there’s some potential memory side effects, cognitive side effects. Number two, I would say making sure that you’re not having to incinerate every time, right? Trying to do of a vaporizer or some kind of other medium that’s not involving the incineration, which exposes the poly aromatic hydrocarbons, the heterocyclic ABGs, the carcinogens that are produced. And uh—the CBD obviously is better just because it’s a less psychoactive, but if you can you know— epileptic stuff, autoimmune stuff, anxiety, mood stuff, the CBD for sure. THC more on the—if the CBD is not working and you need the pain or you have a lot of the nausea stuff that may be better.

Evan Brand: Yup. I mean with the THC, I don’t—I mean I’m sure there’s tons of people that still combust, but you really don’t even have to anymore. There are so many different drops and tinctures and potions and such that you don’t have to burn. You don’t have to burn the herbs anymore. And people don’t want to get high, too. So you could do like a 20% CBD like a 1% THC and you’d probably feel really good.

Dr. Justin Marchegiani:  Yeah. I hate the feeling of being high. I’ve only done it a few times in my life, but I’m tired and I just get the munchies. I’m fatigued and I just get really hungry. It’s like I don’t need that. I want to be energized and alert. And I think a lot of the negative studies on marijuana, too, is number one, you really have to make sure you’re not getting pesticide exposure.

Evan Brand: Exactly.

Dr. Justin Marchegiani: And you have to kind of faired out the burning and the incineration of the leaf.

Evan Brand: Yeah.

Dr. Justin Marchegiani: I think if you pick, take those two components out, I think you’ll see a lot of those confounding variables showing negative results in those studies in proof.

Evan Brand: For me, a vaporizer change my life. When I had IBS, the only thing before I knew about by diet changes that help me was a vaporizer. It would slow down my bowels since I was having so much loose stool. It would regulate the bowels better stomach cramps, stomach pains would go away so I had a lot of hands-on experience— super helpful.

Dr. Justin Marchegiani: Go ahead, I’m sorry.

Evan Brand: I just have to say, I don’t vape anymore currently. One is it’s impossible to find a good source in Kentucky. Now, if I go to Colorado and I could find some good organic, high-quality, I’m gonna take a sample, that’s for sure. But for me, I just— I can’t find a good source here. So I do stick with the—the CBD drops, which is legal, too. You know, it’s another thing. It’s— it’s legal in all 50 states, the CBD is.

Dr. Justin Marchegiani: Totally. And uhm—just kinda –I think a lot of marijuana, maybe not the CBD, because that’s more the— the non-psychoactive. I think a lot of marijuana is used you know, to cover-up emotional stress uhmm—you know to the kind of numb yourself out from whatever’s happening in your life. So we just gotta make sure that you’re not using it to avoid reality, so to speak. But there is a lot of drugs out there that are very dangerous and have a lot of side effects and kill a lot of people. So if we’re choosing marijuana over these drugs that kill a lot, I will always choose the drug that doesn’t have the profile of killing people, right?

Evan Brand: I’ll pick it over alcohol, too.

Dr. Justin Marchegiani: Yeah.

Evan Brand: If I had somebody say, “I wanted to drink a bottle wine every night” or “hit the vaporizer, do a couple of drops of a tincture” The alcohol for me is gonna be a bigger problem coz it’s gonna create the leaky gut situation.

Dr. Justin Marchegiani: Yeah. I mean if you’re drinking excessively, if you’re having a glass or two and it’s organic, you know, you’re probably fine with that on the alcohol side. But if you’re going you know, four glasses a night and then it’s consistent, yeah, they’ve done studies. I think it was a Giuliani report they looked at like the highest ranked college students in the country and they say you know, what do you prefer, alcohol or marijuana as a drug of choice? And the kids that have the highest grades were choosing the marijuana and their main reason was the hangover. They could wake up the next day and studying, get their work done.

Evan Brand: Makes sense. Let’s see if we have any other on-topic questions here. Do you see any others?

Dr. Justin Marchegiani: See here—see, we can find some things that we can connect to our little politician side stepped here.

Evan Brand: Gerald had one, about how do you know if you’re eating too many starchy carbs per week? I— I cycle like it depends on the week and depends on activity level how much I’m gonna do.

Dr. Justin Marchegiani: Yeah. I mean it—I think 50 to 150 is a pretty good place for most people to be. And if you’re doing a lot of lifting or a lot of CrossFit, then you may need to go up to 250. So I think, look at your height and weight. If you’re at a really good height and weight, you’re gonna have more latitude. If you’re lifting a lot of weights, I think you can go up to 150 to 200. If you’re doing Ironmans or like you know, those, then you may have to go way higher than that. So I think you really  just figure out where your activity level is at. Figure out where your height and weight is right now. 50 to 150’s pretty good. And you earn your carbs. So you exercise more, you—and you’re lifting more weights, you can up your carbs a little more and just try to keep it whole food, you’re gonna be fine.

Evan Brand:  Here’s another question about glutamine. Should you take glutamine by itself to repair leaky gut or is it okay to combine with protein?

Dr. Justin Marchegiani: I mean glutamine is an amino acid, but if you mean like glutamine and then have real whole food protein, yeah, that’s fine. I mean in my line, we use GI Restore, which has glutamine and a bunch of their healing things and glucosamine and we’ll mix that and add in a drink, take it on an empty stomach and then patients will still have you know, a really good whole foods meal. Or we’ll add in the collagen as well which is very high in glycine. And glycine’s really good for the enterosite healing as well. So you can do either glutamine. I’ll typically only do L-glutamine by itself for patients that are very, very sensitive. We’ll typically add the healing compound in there, you know, the GI Restore, the all the other, licorice, aloe, slippery elm, glucosamine, right? Modify—We’ll all those in together and if that’s causing too much sensitivity, then we will do L-glutamine by itself. But they gotta really be sensitive if that’s the case.

Evan Brand: Yeah. And that’s— I find that pretty rare. The glutamine by itself to me, it just doesn’t move the needle as quick as the combo products like you talk about.

Dr. Justin Marchegiani: Yeah. Only if there’s an allergy issue. And then, the collagen is great. Glycine’s a really big building block for healthy gut function, too.

Evan Brand: Nice. Bone broth, too. I think that’s another—

Dr. Justin Marchegiani: That is very high in glycine, too. Yup.

Evan Brand: Cool. I think that was it. There were bunch of other questions, but a lot of these were super off subjects, so I don’t want to distract from the convo too much.

Dr. Justin Marchegiani:  Yeah. So—

Evan Brand: The others—

Dr. Justin Marchegiani: I think we kinda hit everything. I want to go off to— you know, off to uhm the kind of the __ James here talks about this just kind of the cost regarding the organic acid test and keeping it low. Typically, if— if you’re trying to keep the cost down with the organics, let’s do the test once a year. You know, do it once a year. Ideally, if you can do it uhm— twice a year, that’s ideal, but if not, you can just do it  once a year. That’s kinda your—your best bet kinda just fine-tune your program once a year with the organics. That’s probably the best way to make it more cost-effective.

Evan Brand: Yup. Well said. Gerald said that we guys are the best. Change his life. Hey, Gerald, thanks. We appreciate it.

Dr. Justin Marchegiani: Uhm—Gerald is actually a patient. Glad we could help, Gerald. That’s very good. And one last question, too. Diana talks about doing a podcast on estrogen dominance and progesterone therapy. Hey, you’re kinda—you’re too late. Check out the podcast’s show notes. We did a podcast on estrogence dominance and we talked about progesterone and __ augmentation programs that we do with progesterone therapy, too. So check out that podcast, Diana.

Evan Brand: Yeah. Go on either uh—Go on Justin’s YouTube. That’s probably the best if it’s posted there or to check out his site Justinhealth and just type in estrogen. You should find it either way.

Dr. Justin Marchegiani: And if you guys enjoy this right now, the best way you can thank us is give us a thumbs up, post, share on your twitter and/or uhm— Facebook. We love it. We just want to help more people and you notice, it’s a lot of people that are out there podcast people, they either hold information back or all they do is spend oh, you know, 90% of the time promoting their products and affiliates. I think 95% of our time is just free intel. Of course, we got a little plug here and there, but we’re 95% free information because we know there’s too many people out there that need all this info and we’re just gonna be an open book to everyone.

Evan Brand: Yup. Totally. So, we hope it helps. And if you need to reach out, schedule a consult with either of us. For Justin, check out his site. Justinhealth.com You can look up and click the book an appointment button. Myself, same thing. Evanbrand.com Check us out. Stalk us. Study us. Look under every crevice and corner. Read our reviews. We’re here for you. We’re happy to help if you got this issue going on.

Dr. Justin Marchegiani: Leave us comments below. Tell us what you like about the podcast and tell us about future podcast that you want to hear. We’re reading them and we get inspired by those comments below. So say, “Hey, I like this about this podcast and I want to hear something about” And tell us that topic we’ll add it to the queue.

Evan Brand: Yes, sir. Good chatting with you.

Dr. Justin Marchegiani: Everyone, have a great day. Take care.

Evan Brand: Take Care.

Dr. Justin Marchegiani: Bye.

 

 


 

References:

Art Naturals Shampoo

Purely Northwest

Justin Health GI Restore

Justin Health GI Clear 2

Justin Health GI Clear 5

Justin Health TruCollagen

 

Leaky Gut and Autoimmunity – Dr. J. Live Podcast #161

Dr. Justin Marchegiani and Evan Brand dive into a discussion about the link between gut infections and autoimmunity. Gain knowledge about leaky gut, how it occurs in the body and it’s connection to Hashimoto’s.

Explore the different stressors which affect gut health and contribute to a weakened immune system. Learn about Dr. Justin’s 6-hour template, which includes his expert recommendation regarding healing, nutrient and supplements.

In this episode, we cover:Leaky gut and autoimmunity

00:34   Leaky Gut and Autoimmunity Connection

04:05   GABA and the Blood Brain Barrier

06:48   Hashimoto’s and Gut Health

12:23   6-hour Template

22:40   Thyroid Health: T3, T4

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Dr. Justin Marchegiani: Hello, ladies and germs! Dr. J in the house. Evan, how we doing, man? How was your Holidays? How’s your Thanksgiving?

Evan Brand: Holidays were great. Let’s dive in. I know we’ve got a short limited of time. But we’re doing this on the fly because this conversation of gut health and gut infections and autoimmunity is huge and hardly anyone is talking about this. Conventional doctors don’t have a clue about the link between gut infections and autoimmunity, so dude, let’s dive right in.

Dr. Justin Marchegiani: That sounds phenomenal. So we talked about in the show, kinda chatting about leaky gut and autoimmunity, which is really important because leaky gut is kind of like one of the primary mechanisms of autoimmunity kinda starting, which is kind of gastrointestinal permeability cells in the gut called the tight junctions. They start to unzip, kinda like you unzip your coat on a hot day and undigested food particles can get in there in this kind of creates this uhm— cascade of reactions call molecular mimicry, where certain food proteins— the surface proteins on these foods are similar to surface proteins of the thyroid or the brain or the pancreas, the beta—the beta cells of the pancreas, whatever. So you have this kind of immune system getting primed to similar proteins in foods which then prime the immune reaction for the immune system. It starts attacking these tissues in the body. So that’s kinda one of the first defenses is this autoimmunity leaky gut, molecular mimicry and that while they gut’s leaky, you have undigested bacterial compounds also getting in there, too. And then kinda just perpetuate and windup that immune system. And then also make it prime to—for other infections that kind of slip in there because the immune system now has weaken. Other infections can slip in. And typically, we’re gonna have a lower stomach acid environment so you’re gonna have less sterility in the stomach coz that low pH really prevents a lot of bacterial and critters from growing. But now that pH is like, you know, it’s like walking over to the dirty picnic tables and normally you spray it down with maybe some bleach. Or let’s say in a healthy version, maybe a really good antimicrobial essential oil. But now, we don’t have that because of the stress from the gut.

Evan Brand: Yup. Well said. Now, Hashimoto’s for example, is probably most common autoimmune condition that we’re going to see and deal with and that probably you guys listening are aware of. Leaky gut has to take place for Hashimoto’s to happen. That’s one of the dominoes that happens. So you’ve got the leaky gut situation. You possibly got the gluten in the diet. You got the immune stress, which could be internal or external. So bad boss, bad spouse, bad relationships, bad job— those are kind of the big dominoes we see. And when you all those up together, that’s how you get autoimmune disease. It’s really just that simple.

Dr. Justin Marchegiani: Totally. And then we have people on the live chat here. And again, this is a great reason why you should subscribe to our YouTube channel—justinhealth. Uhm because we have these podcast going live as well and we’ve also incorporated other technology in the background to get a higher quality audio versions. So if you want better audio, you can subscribe to Youtube, but also check out our podcast uhm—Evan Brand, notjustpaleo and then beyond wellness radio myself. So just keep that in the back of your head. And then your question was—I just missed it. We talked about—Oh, yeah! Leaky brain. Leaky brain is connected as well coz we have these live questions coming in. And so we are multitasking like it’s no tomorrow. So leaky brain’s important because we have these called astrocytes or the brain blood or the blood brain barrier which is kind of the interplay between systemic blood and then the passing over to the brain. And we have the cells called astrocytes. And again, same thing, when we have gut lining integrity, it tends to affect integrity of the lungs, integrity of the sinuses, integrity of you know, vaginal wall area, urinary tract. So you have people that have gut issues—gut integrity issues. It almost always can cause sinus issues, brain fog, brain issues, UTI issues, bladder issues, right? So you have all of that mucous membrane barrier, it’s gonna be compromised throughout the body not just the gut. But the guts kind of that first major domino that falls and then everything else tends to follow along with it.

Evan Brand: What you think about the GABA test for the blood brain barrier, where you take like a 500 mg GABA and if it works and you get relaxed, that says you have a leaky brain. Do you agree with that?

Dr. Justin Marchegiani: I’m not sure I buy that because I’ve seen people that do—that are really healthy and that do well with GABA.

Evan Brand: Yeah.

Dr. Justin Marchegiani: And they, you know, symptomatically, they’re doing pretty good. They’re eating well. Again, certain supplement companies have kinda put that out where they have a GABA challenge. They say, “Hey, GABA is this really big amino acid compound and it shouldn’t go through that blood brain barrier; therefore if it does, that means your major blood brain barrier is permeable.” I’m not sure I buy that. I think it’s something to keep in mind, something to try. I have a lot of patient that have gut issues and they’re sick and that use GABA or will only give them GABA and they don’t notice much benefit either.

Evan Brand: Yeah.

Dr. Justin Marchegiani: So, you know, how do you sparse that? That’s hard.

Evan Brand: I know. Who knows, man. That’s a good question.

Dr. Justin Marchegiani: Everyone tries to be a little bit trendy and nuance in this functional medicine field.

Evan Brand: Yeah.

Dr. Justin Marchegiani: Because they wanna make a name for themselves.

Evan Brand: Yeah.

Dr. Justin Marchegiani: And I get that from a marketing perspective, but just looking at the clinical application, I’m not sure there’s ton.  But, heck, if you have GABA and you want to try it and you get uh—benefits, that’s great. I notice a little bit of improvement with GABA. Like when I take it, I feel little but relax. I also do that with Ashwagandha as well. I feel it with magnesium. Someone chimed in and asked if magnesium can be taken with Ashwagandha. Yeah, sure. I’ve no problem with that.

Evan Brand: Works great.

Dr. Justin Marchegiani: Hope everyone’s listening had a great Thanksgiving, too.

Evan Brand: Yeah. Tesa wants to know, “Have you reversed your Hashimoto’s, Dr. J, by healing the gut?”

Dr. Justin Marchegiani: Well, so we have to be careful when we say reversed, right? So have we decrease the inflammation? Have we address underlying issues that made people susceptible to having autoimmune attack? And we—can we lessen those and decrease them to the point where we are no longer symptomatic because we have the inflammation down or quench enough? Yes. I’m just very careful because you know, eyes in the skies and people listening in they’re— they’re looking for that the cure the cure-all word, right? We just got to be careful. We don’t cure anything. We support the body’s ability to—we support the underlying stressors that cause the issue to begin with. And we support the underlying systems that weren’t functioning well. And then the body can start to get these symptoms under control because the symptoms are just a manifestation of the symptoms— the systems not working. Symptoms occur because systems aren’t working. Systems breakdown because of underlying stressors. As functional medicine doctors, we come in, we fixed the underlying stressors, we support the systems that aren’t working and then the body starts to heal itself, right? The body’s on autopilot. We just got to get the stressors in the systems work. If the system’s working, then get the stressors out of the way.

Evan Brand: Yup. Well said. So you had some— you had some gut bugs and things going on, do you care to talk about your story for a minute with the – Hashimoto’s?

Dr. Justin Marchegiani: Yeah. I have—I have a low level of Hashimoto’s kinda in the background, I had elevation antibodies TPO and thyroglobulin antibodies and you know, I had some adrenal stress going on. And I just really worked on fixing the gut issues, which I had a handful parasites—Blasto, uhm— yeast, significant yeast overgrowth and H. pylori. Addressing those, fixing nutrient issues to help with the antibodies, fixing the digestion, fixing gut bacteria balance is of course working on stress reduction, sleep, all those important diet and lifestyle things. And again, the antibodies for me are just still slightly elevated, but there they’re in a range where you know, functionally my thyroid is not beaten up to the point where I need any thyroid hormone. My TSH is in a pretty good place and my T3 levels are pretty good. I actually have to go on for test real soon. So, yeah, I mean it’s possible to—to address the stressors and the system dysfunction to the point where you may not— you can call yourself cure. We just won’t call you cure for me, a functional medicine perspective.

Evan Brand: Yeah. Agreed. I need to get my thyroid panel run to. You’ve been pushing me to do it.

Dr. Justin Marchegiani: Yeah. You should.

Evan Brand: I need to do it. I mean you and I both have had these infections. I had H. pylori as well. I had a Crypto, Giardia and yeast and Pseudomonas Aeruginosa.  So, you know, that’s a fun thing about Justin and I. We both had all the things that we deal with in the clinic. So when you guys are looking to work with somebody, it’s— to me it’s a lot more honorable if you’ve had somebody that’s been in the trenches themselves, where we had to fix us to keep going to help other people. I think that’s always pretty cool. Uhm— what else I know we would have limited time, but what else should we mention here about kinda this autoimmunity piece, the gut piece. We mentioned the leaky gut, we mentioned some of the triggers just in a roundabout way. So Candida, bacterial infections, parasites, H. pylori, low stomach acid, gluten in the diet, dairy, possibly eggs, other food sensitivities. These could all contribute to that permeation of the gut barrier; therefore, causing the situation.

Dr. Justin Marchegiani: Hundred Percent. So, let me just kind of answer some of the things that you’re talking about while injecting some of the live questions we get. That’s the reason why the show is so unique compared to other shows coz we are off-the-cuff. This is the real deal here. So some patients are talking about having a lot of mucusy stools, right? And uhm— wanting to know where they should go for help, right? Of course, I recommend coming to see either myself or Evan, but typically one, we want to make sure food allergens aren’t driving this, right? Number two, we want to make sure we have enough digestive support on board to help those foods be broken down enough. So if there’s fat maldigestion issues, of course, adding in more bile salts or more lipolytic enzyme, right? Lipase— things like that. Uh— protease—proteolytic enzymes, right? These are all really important. And then, of course, once we can have the deck kinda dialed in, if foods are still a problem even with that, we may make them more palatable. We may go with more crockpot kinda GAP specific carbohydrate kind of eating template, where the foods are just easy—more processed via cooking, they aren’t raw, they are peeled or mashed. We’re decreasing salicylates and phenols and potential gut irritants so those foods can be consumed better. And then, of course, we’re gonna look deeper at the hormones because hormones have a major effect on inflammation and energy. And a lot of people that have gut issues, their guts are inflamed, we have to support the inflammation of the gut lining. And then, the big one is getting rid of the infections.

Evan Brand: Yup.

Dr. Justin Marchegiani: And that’s where you know, we’re probably go next.

Evan Brand: (laughs) Yes. You’re right. So uh—Cent50 here, who asked the question. Yeah, the loose, mushy stools, I mean that was me. I had Cryptosporidium, I had Giardia, I had H. Pylori, I had bacterial overgrowth. Until my gut issues were addressed, just FYI, I had IBS for 10 or 15 years of my life and conventional doctors had no solutions for my—my stools. And it wasn’t until actually cleared out the infections that my bowels and my stools became normal again. And so, yeah, you got to get yourself tested. Justin and I run several different companies. Uh—stool testing just depending on you know what—what we’re looking at. But, yeah, get a comprehensive stool test. Your conventional doctor may be able to order through your insurance, if you tell them you want diagnostic solutions Lab, it’s unlikely. You probably have a functional medicine guy like us to run it for you. But either way, once you get the diagnostic tool, you can fix this pretty quick.

Dr. Justin Marchegiani: There’s a lot of healing nutrients. So like, when we work with the patient, we kinda follow that 6-hour template— template that I’ve created over the last decade or so. There’s a lot of ones that are out there— three hours, four hours. In my opinion, a lot of them stink and they’re the wrong order. So the six that I’ve created and began to follow as well, in my opinion, is the exact clinical order which I follow things. So the first hour is removing the bad foods. And again, it’s not cookie-cutter because that maybe just getting someone from a standard American diet to a Paleo template. That may be taking someone from a Paleo template to an autoimmune template. Maybe someone on an autoimmune template and the Paleo template taking them to a GAPs or specific carbohydrate diet or low FODMAP template. I had patient last week who’s been Paleo for three or four years—chronic pain, chronic issues, chronic mood issues, chronic sleep issues. We took him from a Paleo template to an autoimmune-Paleo template and all of the symptoms went away in one week.

Evan Brand: That’s it.

Dr. Justin Marchegiani: This is someone that’s like already been on point for a long time and we just pulled out a few foods. So we have those— that kind of progression because you’d be surprised, the smallest things that we do have a huge effect. And it’s like, whoa! you would’ve thought I would have created the awesomeness protocol ever and found a you know, this hidden infection that everyone missed and got rid of it for that kind of improvement to happen. But sometimes it happens, we’re just removing some food. So, first, I remove the foods, second, I replace enzymes, acids, digestive support, bile salts, too. Third hour is gonna be repairing the gut lining. It could be also repairing the thyroid and adrenals and sex hormones, too. Fourth hour is removing infections. That’s where we go after— bacteria, parasites, uhm—fungal overgrowth. Those kinda things. We may even go after co-infections future podcast on that soon enough. Fifth hour, repopulating or reinoculating probotics. Some of these nice and beneficial bacteria. They’re transient. They only hang out for a month or so and pass on. So, getting some of that it in there periodically is helpful. Sixth hour is retest. We want to make sure infections are gone. And maybe even address family members too to make sure they are not being passed back and forth you know, playing hot potato.

Evan Brand: Yup. Well said. Riley asked a question about—he said, “Evan is your IBS completely healed now after addressing anything?” Uhmm—kind of a confusing question about addressing anything. Yeah, I don’t have IBS anymore. I’m infection free, no more H. pylori, no more parasites, no more bacterial overgrowth, no more yeast overgrowth and I feel good and feel completely normal, which was an amazing thing because after so long, you know, it took me to be so long to get here.

Dr. Justin Marchegiani: Totally. And with your situation, right? Like if you start eating bad foods again and your immune system got compromised, you may have another critter or two that pops back. You may have some inflammation from the food and such. And then those symptoms, they start coming back, right? So it’s not like a cure, like, “Hey, you have scurvy. Here’s vitamin C.” And then as long as the vitamin C is there, you’re good forever, right? It’s like, “Hey, there may be other stressors that may cause the systems to weaken again and those IBS symptoms start to occur, right?”

Evan Brand: Oh, Totally! Yeah. I mean I could go— I could go out to a restaurant and get some type of contaminated food and all the sudden creates a leaky gut situation. Maybe I pick up a gut bug, maybe I was eating while stressed during a week and I didn’t chew my food good. And then I picked up a parasite and have to start all over again. So, yeah, definitely, you know, you could always backtrack. You’re—you’re never permanently in a good place.

Dr. Justin Marchegiani: Totally. And again, one thing I see out there on Facebook, and I see it marketed, and it’s–  I have to call—I’m not  gonna call anyone out directly—

Evan Brand: No, come on. Do it.

Dr. Justin Marchegiani: I’ll call out the concept. But lots of people, they’re like, “You gotta heal leaky gut. Here’s a gut healing program.”

Evan Brand: Yeah.

Dr. Justin Marchegiani: And if you look at it, a lot of times, you know, it’s bone broth or just a lot of healing nutrients and a lot of probiotics, right? And maybe a little diet change. But if we go look at the six hours, what are they really doing? They’re doing the third hour, maybe a little bit of the first, maybe a little bit of the second, maybe a little bit of the fifth, right? They’re kinda skipping around. They don’t have a system and how it’s being integrated a lot of times. And I would say 99% of the time, it ignores going after and getting the infections fixed. Totally ignores it. Because you know, these people are recommending a general program to like thousand people at once in a huge kind of a webinar kind of style, right? Well, how do you get all the types of testing and customize everything in that format? You can’t. So it’s a very general kinda overview approach. And in my opinion, it’s going help some people, which I think is great. It’s admirable. But it’s also gonna  a miss a lot of people and those people that don’t get help may lose faith in functional medicine or say, “This is not for me.” So I’m just kinda calling that out because think about it, right? If the root cause of what’s going on is an infection component and you’re doing let’s say the first, second, third, fifth alright but you’re not getting rid of the infection. Well that’s like me giving you this healing aloe, right? You get a sunburn, you come back from the beach, I give you this aloe, right? The underlying cause of the sunburn is the— is the sun. And then you go back out the next day and you get sunburned again and I just give you more aloe. That’s the equivalent of what a lot of these people are doing. Well, just have some more bone broth, have some more of glutamine, have some more of this healing compound for your gut lining. So we got to get to the root cause. A lot of people are just being very general out there. And you know, the listeners of our show will get it and say, “Hey, I see that the missing piece there.” And that’s why we have those six hours that way coz then you can look at it and you can say, “Hey, this is a really specific way we go about addressing things here.”

Evan Brand: Yeah. Well said, man. And that’s the food is medicine, people. And we love the food as medicine people, but that’s why you know, we pursued functional medicine because the food is just the first step, right? It’s just one pillar of the house. It’s not gonna hold the house by itself as a single column. And also, I want to mention the order—the order of operations. If somebody just go straight to bone broth and probiotics and L-glutamine, that’s the wrong order. And sometimes people get worse. They’ll come to us and say, “Oh, Justin and Evan—“

Dr. Justin Marchegiani: Yup.

Evan Brand: “I took XYZ probiotics coz I heard it on a podcast or a blog and I felt terrible and I had a flare up of my condition. Can you explain what happened?” Yes, if things are just terrible in the gut,. sometimes you have to hit the reset button. You can’t immediately just add in all these probiotics and expect it to work. Sometimes we have to fix the balance first and eradicate the bad guys before the good guys can come back in.  So that’s why the order of operation is just a second when Justin said it’s so important. And this may explain why you’re spinning your wheels even though you’re all—you’re doing everything about the Paleo gurus are saying to do.

Dr. Justin Marchegiani: Yeah. We just want to make sure everyone’s educated. I mean, we have some people out here, they’re chiming about, “Hey, I really want a functional medicine doctor but I don’t have the—the money for it.” Well, guess what? The best thing that you can do right now is be listening to our podcast coz all this information is free.

Evan Brand: Yup.

Dr. Justin Marchegiani: We’re providing tens and thousands of dollars for free information off of people and I get messages all the time. “Hey, made a couple of these changes or recommendations and my autoimmune condition for 10 years is gone.” Right? I didn’t cure him.  I promise. I didn’t cure him, right? The body just heals itself, right? We got to say that as our disclaimer. But that’s you know, what’s that worth. When someone is you know, seeing a rheumatologist for 20 years on lots of expensive medication that’s tearing up their gut and their body and creating more symptoms than they’re actually helping. What’s that worth? So just utilize the pickup as much of the free intel as much as possible. And then you know, allocate some savings or HSA or flex spending. So if you want to dig in deeper, that’s an option. But utilize as much of the free stuff as possible because the diet is the foundation.

Evan Brand: Yup.

Dr. Justin Marchegiani: 50% is gonna be the diet so work on that first. Once you max that out, and you’re seeing some decent results, then you’d want to go in deeper. You can reach out, for sure.

Evan Brand: Yeah. And you can contact likely so. You can contact your conventional doc and try to get some stuff run through insurance. But it’s likely that they don’t have accounts with these functional labs and they likely just aren’t going to do it. Fut if you’re really lucky, you’ve got a really good M.D., you may be able to push push push push at least get the lab so you have the data. Now what you do with the data? Well then maybe that’s where you come to a functional medicine guy that can help in terms of creating a protocol. But getting the data should not be impossible.

Dr. Justin Marchegiani: Totally. And a lot of functional medicine docs that do a podcast or websites, I find that they take information, they wrap it up and they try to make people feel so confused where they walk away from the podcast or the video, being like, “What the hell just happened? What I do now ?” And they walk away feeling less certain. I want to make sure no one walks away from any podcast or video I do, gaining more certainty. And at least walking away with one action item that they can add into the repertoire of whether it’s a lifestyle or a supplement or just a different perspective on the6 hoir healing so they get better and they feel more confident.

Evan Brand: Yeah. I watch a couple of functional medicine videos like over the weekend and they were like hour-long videos I made it through 10 minutes. And I thought, “This is not gonna help me at all.” So I decided to turn it off. So let’s do it, let’s do our action steps and summary here.

Dr. Justin Marchegiani: So of course, we have our six hours, right? So everyone listening kind of our general feedback is gonna be a Paleo autoimmune template to start. And again, depending on where you’re at, that maybe really a lot of— really overwhelming for you, cutting out grains, legumes, dairy and primarily having healthy fats, proteins, uhm more veggies and fruit instead of starch. And having healthy fats like you know, if we’re doing a Paleo, maybe a little butter or ghee. If we’re going fully AIP, no nuts, no seeds, no dairy. Just coconut, Olive oil, may be avocado oil, some healthy animal fats. And that will be a good starting point for people. And then again, an AIP or an SCD or autoimmune diet, again, I’m just kinda laying out the Paleo template to start coz that’s probably the easiest buy in without pre qualifying anyone. I would say that after that, at least getting some digestive support going there. And again, you know, the ones that we formulated, we recommend the most coz we’ve put our stamp of approval. High-quality HCl or enzymes. In my line, it’s HCl supreme or enzyme synergy or I’ll add in the liver supreme for extra bile support for digest energy. And Evans line—Evan has a similar products as well. Uhm— so that’s a good starting point there. And then seeing where you’re at, I think is the next step coz there may be infections, there may be other testing that has to go in deeper. So I think if you can get that, that’s number one. And then I think if you can just make sure the hydration component and the sleep component is dialed in next, that’s a good second step. And that gives most people of really good you know, path to go down and if people are listening, they’ve already done that and they’re like, “what’s next?” well, that’s where I think you’d want to reach out and do a little bit more testing because that’s what I think the infection component and/or the hormone component and/or the nutriend malabsorption component from the infection could be the next vector we’d really have to put up in our sites, so to speak.

Evan Brand: I’m gonna address one comment here and then I’ll bring up a question then we could uh—we could wrap it up. Leslie mentioned the diet’s the foundation which kinda sucks no more pigging out in the middle of the night. The good thing is that could be related to infections. I mean for me, for example, when I had parasites, I would get these food cravings that just didn’t make sense and it wasn’t me. It’s these bugs. They are stealing your nutrients, they want food so they’re cannibalizing your muscle tissue and when you’re eating, they’re messing up your ability to digest especially coz I had H. pylori. My stomach acid levels were lower. I was basically hungry all the time and I was losing weight. Getting to like a scary point of weight loss. So really, the diet is not too hard once you just address your gut bugs, that— the whole like binging type thing on food, it really doesn’t happen once your gut is healed, once your adrenals and your thyroid are helped out and your blood sugar’s more stable. It’s not an issue. I mean you could fasted for a long time and feel stable. You shouldn’t have to get hungry or go on a crisis stage. Justin, a question for you. Uh—some doctors say T3 doesn’t matter; they don’t test it on Thyroid labs. The person’s taking T3 now slowly increasing. Would you be lowering T4 when adding this?

Dr. Justin Marchegiani: Well, I would typically be adding more than likely a T4, T3 put together so there’s gonna be a combination of both. Most doctors don’t care about uhm—T3 because the major pharmaceutical companies, Abbott’s the big one, that has a patent on Synthroid is a synthetic T4. It’s easier to monitor uhm— giving a T4 the half-life’s five days, so it’s really easy. It’s not like a T3, which could potentially have more side effects. Uhm—and it’s patentable, right? It’s the basically tetraiodothyronine with the sodium salt on it. So that’s how they get the patent to it. Uhm—again, they don’t m__ it because that’s just not what they do. They give you the T4, they get the TSH back in range. All your thyroid symptoms could still be present. Cold hands, cold feet, anxiety, mood issues, hair thinning, you know, gut here fitting things you know, gut stuff, constipation all could still be there, but if the TSH is in range, they’re happy. They checked off the list, you’re gone. So that’s where you got a dig in deeper. You got a look at the T4, T3 conversion. You got to look at the autoimmunity. You got a look at the nutrients. You gotta look at the adrenal conversion, the gut conversion connection and the liver detox conversion connection, too.

Evan Brand: Yup. Yup. Should you ignore TSH? No. It’s definitely worth factoring TSH in. You just don’t want to use that as the end-all be-all only marker. But you— but when you have the free T3 and the reverse T3, the TPO, the TG antibodies kinda all the stuff we run, the TSH makes a lot more sense when you got a full picture.

Dr. Justin Marchegiani: Yeah. We like to keep TSH in the equation and look at sometimes people come in with the TSH that’s perfect, but their T4 T3 conversion sucks. And then what do you do? You know when you’re treating the TSH or are you treating the actual patient? So we’ll try to increase thyroid hormones, see if symptoms change and we’ll try to support HPT access communication with specific herbs. And of course, stress modulation and getting infections— getting rid of infections coz that can really mess up the HPT access, the Hypothalamus Pituitary Thyroid connection.

Evan Brand: Yup. For sure. Uh—Leslie and a couple other comments about you know, where to go next? Well, I mean, you know, if people may say, “Oh, we’re biased.” But the answer is get tested. Our philosophy is “Test, don’t guess.” So if you’re confused, you’ve got symptoms that don’t make sense, get tested. That’s the first step. You can look at adrenals, thyroid, gut, get all the puzzle pieces laid on the table. That way you’re not just buying random supplements that you might not actually need. We’ve seen so many people with 20 and 30 supplements that they’re taking and they still feel terrible. And we cut that down to five supplements because it’s based on labs and all of a sudden people get better. So you know, save up your money for that. Maybe you don’t go buy the next newest supplement you hear about. Maybe you— you focus on investing into some testing first.

Dr. Justin Marchegiani: Exactly.

Evan Brand: And you can check it out on Justin’s site. It’s Justinhealth.com You can look at the supplements, the labs on there. Same thing on my site, Evanbrand.com and we’re happy to help. So, feel free to reach out.

Dr. Justin Marchegiani: Totally. And also, couple of people asked about Dr. Gundry’s The Low Lectin Protocol. I think it’s the plant paradox. Again, my thing is if you’re just going to a Paleo template, you’re gonna cut a lot of those lectins out. If you actually cook some of the plants, some of the starches,  some of the vegetables and lower the lectins even more, if you still have a lot of gut issues, upgrading it to an autoimmune protocol, you decrease lectins more. If we still have issues and we can move to a specific carbohydrate or GAPS protocol and we decrease lectins even more. So it just depends on where you’re at cooking knocks a great chunk of that out and just going to a Paleo template, where we’re cutting out grains, legumes, dairy and focusing more on non-starchy veg, uhm— lower glycemic, low sugar fruits and safe starches that aren’t grain-based, you’re gonna have a huge effect and grains, where most of the lectins and irritants come from. So again, that— my opinion matches people making things a little bit more complicated than they have to be.

Evan Brand: Marketing.

Dr. Justin Marchegiani: Uh-hmm.

Evan Brand: I mean, he’s done a good job that book is spread.

Dr. Justin Marchegiani: Yeah. It has gone viral. Everyone asked me about it all the time. I can’t get a go of a— one day without a patient asking me about it. So I have to follow it. I think I found it on fast reads on Amazon. So I got a—like uhm—abridged version of it that I’m siphoning through.

Evan Brand: Nice.

Dr. Justin Marchegiani: I’ve got a couple of services where they do these summaries. And it’a great.  I mean I get 90% of the information.

Evan Brand: Exactly.

Dr. Justin Marchegiani: Suck it up in a half hour and I’m like, “Oop, got it!” That’s it. On to the next one. Well, any other questions you wanted to answer here, Evan?

Evan Brand: I think that’s everything. I think that’s all we can—we can chat on today and we’re gonna do a podcast soon on co-infections. We’re gonna talk about Lyme, Bartonella and Babesia Uh—Justin and I, I mean, we’ve literally got the books like right here that we’re—we’re diving into.  We wanna make sure we’re the most educated and current up-to-date with our information before we broadcast to you guys. So make sure you hit subscribe on Justin’s YouTube channel while you’re at, hit subscribe. And uh—we’ll be back again soon.

Dr. Justin Marchegiani: Totally. And one last thing. Patient asked here—person asked here on the chat list, uhm—“How do you—how do you choose your functional medicine doctor? How do you trust them?” He said, “I can’t trust them. How do I choose them?” Well, number one, I think they should have some kind of content out there whether its video, audio and/or blog post where you resonate with their information. Like their philosophy, their information, you should resonate. I find most patients are the biggest reason why they don’t get better is because, number one, compliance, and number two, they’ve been burnt and the past or they failed in the past and therefore they’re kind of priming their subconscious to fail again. So they don’t follow through and they’re off to the next one other, you know, they’re making a 180 move in can’t see someone else because some little thing happened. They’re not following through enough. So I think keeping—one, making sure you choose someone based on their philosophy and the information and making sure you resonate at an emotional level and just a logical level. Here’s the plan, generally speaking, right? And then number two, making sure you’ve given enough time and then follow through uh—for it to work.

Evan Brand: Yup. Well said. I’ll address— address this last question, then we’ll roll here. Uh—Is it common to have to go through a few rounds of infection killing protocols? Yes.

Dr. Justin Marchegiani: It can.

Evan Brand: You can. It took me a couple of rounds to go through, some herbs to knockout things coz I have multiple infections. When you’re trying to kill five or six or seven things at once, yeah. I can’t take multiple rounds. Why is that? Depends on the person’s immune system health or stress levels, how long they’ve had infections, the amount of damage that’s there, how much inflammation is there, are they sleeping well, do they have a good diet. You know, there’s million factors to answer why that— why that could be. Hope that helps.

Dr. Justin Marchegiani: That’s great.

Evan Brand: Andrea is asking a question about his father’s prostate cancer. PSA levels are rising rapidly. Can we cast opinions or advice?

Evan Brand: I can’t. Justin?

Dr. Justin Marchegiani: That’s about thyroid, it’s about uhm— prostate issues?

Evan Brand: Yeah. Prostate. Prostate cancer this drug—Enzalutamide had been recommended for father’s prostate cancer PSA levels are rising rapidly. Can you cast opinions or advice?

Dr. Justin Marchegiani: Well, let me describe– I have one formula here that’s been helpful. Yeah. I have one compound here that I’ve been using here, just I had a couple of supplement companies reach out and I’m using it. It’s the pomegranate extract, and the flower pollen extract and its cranberry extract. So cranberry, pomegranate and flower pollen. This is an excellent support. Lot of research behind those extracts as well. Lycopene is phenomenal, getting adequate levels of selenium 200 mics a day is phenomenal, enough zinc as well is phenomenal saw palmetto’s great. These are excellent compounds that help. Lycopene is phenomenal as well. Again, the diet has to be in place. You want to get the lifestyle things going and again, these things don’t grow overnight. They probably taken decades to kind of move. So coffee and Coffee enemas may also be helpful to kind of early push detox in a faster more acute kind of way. But some  couple of compounds that I mentioned are phenomenal and wouldn’t hurt getting them on board in the meantime.

Evan Brand: Yeah. And look at my podcast I did with the lady named Dr. Nasha Winters.

Dr. Justin Marchegiani: Uh-hmm.

Evan Brand: She did a book that’s called, “The Metabolic Approach to Cancer” She— she had cancer herself and she’s been holistically supporting people with cancer for about 20 years. So uh— look up Nasha Winters and uh look up her book and you could implement some strategies there hopefully.

Dr. Justin Marchegiani: Also, get the insulin levels under control. Make sure fasting insulin is five or below at least. That’s important because insulin is gonna cause a lot of cells to grow and then also making sure xenoestrogen exposure is mitigated, right? Don’t drink out of plastic bottles, avoid pesticides and GMO’s and glyphosate and Roundup. These are chemicals that you’re gonna get from conventional foods. Obviously, eat organic, right? Pasteur-fed meats. Again, these things— I shouldn’t have to repeat them, but I just can’t assume that everyone knows these stuff.

Evan Brand: They don’t. Not everyone does. So, yeah, keep repeating it and keep preaching. And I think that’s all the questions. So we did— we did really good. That was fun.

Dr. Justin Marchegiani: I heard a quote back. It’s a quote from the 1940s, where Joe DiMaggio was interviewed and they said that Joe said, “We noticed that you sprint on and off the field every single time at full speed no matter what.” And he said, “Well, there may be someone coming out to see me for the first time ever that seeing me play the way I’m playing and I wanna play at 100% every time.” And then maybe some people that are coming out for the first time seeing us play here, and we want to make sure that they get that information that we may assume that other people uh— may have, right? The equivalent will be like us jogging on the field, so to speak, if we just assume that.

Evan Brand: Yup.  Well said. Well, reach out if you need help. Justinhealth.com You can schedule with Justin. Evanbrand.com if you’d like to schedule consults with us. We should have some availability in the next 3 to 6 weeks or so. So just take a look and  we’re happy to help you soon as we can.

Dr. Justin Marchegiani: Oh, by the way, I’m adding in the Mimosa Pudica as well. So I’ll be reporting back on that in the next couple weeks. I think you as well Evan. So we’ll chat about that.  Again, I just got that in stock. That’s the Para-1 in my store. I think you have it in your store as well. So, we’ll put that in the show links, too. So that’s a cool new herb that we’re working on. We have a couple other herbal compounds in the mix that we’re using for different types of co-infections that we’re researching uhm—in the background, too.

Evan Brand: Awesome.

Dr. Justin Marchegiani: Hey, Evan, great chatting with you, man. You have an awesome day. We’ll chat soon.

Evan Brand: You too. Take care

Dr. Justin Marchegiani: Bye.

Evan Brand: Bye.


References:

https://justinhealth.com/products/para-1/

https://justinhealth.com/products/betaine-hcl-supreme/

https://justinhealth.com/products/liver-supreme/

https://justinhealth.com/products/enzyme-synergy/

https://www.mykidcurescancer.com/nasha-winters/

 

Top Anti-Aging Foods

Top Anti Aging Foods

By Dr. Justin Marchegiani

Everyone ages, the question, therefore, is not will you age, but how will you age? Will you suffer from chronic pain and inflammation, develop diseases such as dementia, diabetes, and cancer, lose your mental capacities or your ability to walk and run? Or will you remain in good health with good posture, retain a great state of mind and mental clarity, keep balanced hormones and healthy relationships?

The truth is, the choice is yours, and it is exactly that: a choice. If you are determined to live a long life with your body and energy at their fullest potential, you can do so! However, there are no magic creams or pills that will prevent you from showing signs of aging. The secret to aging gracefully and successfully lies in a series of healthy diet and lifestyle choices which we will outline below.

What is Aging?

What is Aging?

Disease, dementia, cancer, loose saggy skin, slowed brain function, slow and weakened body: these are NOT predetermined signs of aging! These are the consequences of the Standard American diet (SAD) and lifestyle that have been normalized by our society. Recent discoveries have shown that inflammation, the shortening of your telomeres, and  mitochondrial deterioration are what control the aging process.

Click here to schedule a consult with a functional medicine doctor to determine your personal causes of inflammation and illness!

What Causes Aging?

What causes aging?

Inflammation causes the diseases and health decline that are hallmark symptoms of aging, which can eventually lead to autoimmune disease and cancer. This can be combated by finding the root cause of inflammation (commonly diet-related) and taking steps to prevent it.

Telomeres sit at the end of our DNA, and their length is related to our biological age (different from our chronological age, which counts birthdays, your biological age is how old your body is in relationship to your health). Telomeres are shortened by unhealthy habits such as smoking, and eating inflammatory foods.

Our mitochondria produce 95% of our energy, in the form of ATP, but the byproduct of the energy production is harmful free radicals which cause damage to the mitochondria. Science has shown certain foods, as well as the enzyme CoQ10, to be powerful in defending against free radical damage.

How to Age Successfully

How to age successfully

We are able to curtail disease, wrinkles, and a general decline in health through taking proper care of our bodies. A big part of preventing disease and deterioration as you age is dependent on your diet. The following foods are just some of the many healthy options we have that are full of the nutrients and minerals vital for good health and longevity:

Bright colored fruits and veggies provide beta-carotene and vitamin A, which protect against cellular damage and premature aging. They are also great for your skin and eyes, meaning less wrinkles and better vision. These include: bell peppers, carrots, sweet potato, and broccoli.

Leafy greens, such as spinach, collard greens, lettuce, and kale, contain several top antioxidants. Lutein and zeaxanthin have been shown to reduce the risk of cataracts and macular degeneration. Beta-carotene, vitamin C, and sulforaphane are cancer-fighting antioxidants present in leafy greens. The folate in spinach improves your short-term memory and might even lower the risk of developing heart disease and cancer. Vitamin K1 is found in collard and salad greens, which is linked to vascular health, strong bones, prevention of heart disease and Alzheimer’s disease, and can treat certain cancers.

Eggs also contain lutein and zeaxanthin, making them an unexpected friend of your eyes. They are a natural source of vitamin D, as well as choline, which protects your brain, nervous system, and heart. Be sure to buy organic, pastured eggs for all the benefits they have to offer!

Blueberries are chock-full of antioxidant power. By fighting oxidative stress, blueberries can help neutralize the damage caused by free radicals. They help reduce the risk of cancer, heart disease, stroke, and arthritis while boosting your vision and immune system!

Citrus contains vitamin C, which helps your body produce collagen. Collagen is responsible for healthy joints as well as tight, healthy skin. The quercetin in citrus has anti-aging properties and also helps fight inflammation.

Takeaway

Takeaway

You are what you eat, so if your goal is to be healthy and thriving in old age, the food choices you make today need to be healthy ones. Luckily, these foods are not only dense in important nutrients, they are also delicious!

Click here for a consultation with a functional medicine doctor and a personalized health plan!

REFERENCES:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3370421/

http://www.cell.com/molecular-cell/pdf/S1097-2765(16)00081-2.pdf

https://www.jci.org/articles/view/64125

http://enews.tufts.edu/stories/101399BlueberriesMayImproveMemory.htm

Hacking the Holidays – Dr. J Live Podcast #160

Dr. Justin Marchegiani discusses different options, substitutions and modifications that can be made during the holiday season. Learn about what ingredients to use in some of the traditional Thanksgiving dishes including the turkey, stuffing and gravy that can help to still improve your health. 

Gain insight on the different modifications and options that you can use for some of your desserts so you can still indulge without having to feel guilty afterwards. Also, learn about some other cool options including meal timing, fasting, exercise and alcohol intake for a healthier you during this holiday season.Healthy Holiday Recipes

In this episode, we cover:

01:49   Grain-free holiday meal

03:01   Enzyme Support

05:55   Desserts Options

10:36   Timing Recommendations and Alcohol

15:00   Exercise

Youtube-icon

 



Dr. Justin Marchegiani:  Hey, everyone! It’s Dr. J here.  Evan, Happy Holidays, man! We got a short Thanksgiving Day week. I love turkey day, man. Some time with the family, really good eating. Are you excited too?

Evan Brand: I am and I’ve got blue skies here which is very unusual for this time of year. We’ve got sunny every single day this week. So I’m super grateful for that.

Dr. Justin Marchegiani: Love it. Yeah, it’s a great time of the year. It’s uh— important year, time of the year to be really grateful and to be extra uh— particular in all the things that we have to be thankful for. Coz there’s a lot of things but it’s easy to be so focused on everything it’s not there. So we got to really focus on all the things that are there. So couple that is just how about, just some really good Intel that we can use to hack our holidays. Meaning we can still indulge in feel good and connect with our family members but not go into a food coma and feel like absolute crap. What do you think about that?

Evan Brand: Agreed. Yeah. A lot of our clients recommend we do this subject because they feel deprived if they’re doing AIP or some type of dietary approach. They feel like that we’re the bad guys and we’re making their holidays not as fun. But that doesn’t have to be the case.

Dr. Justin Marchegiani: Absolutely. So, couple of things if you look at Thanksgiving, it can totally be Paleo, right? We have like basically the centerpiece in the Thanksgiving Day meal is the turkey, right? Awesome. Especially if we can go after the darker meat. That’s gonna be excellent. Good fats, right? Try to buy an organic or at least a Pasteur-fed turkey. It costs a little bit more but the nutrients are to be much higher, right? So you get good fats and proteins there. That’s the kind of a starting point. And then after that, you control your sides. So most people want mashed potatoes and maybe squash which you know, I’m okay doing a little bit more starch in the holidays. I’m okay with that.  It’s better than doing, let’s say a grain-based stuffing, that’s number one. Number two, we try to substitute for the things that we typically have grains. What’s gonna have grains? Well, typically, your gravy is gonna be thickened with flour so we do a gravy that’s gonna be a carrot and celery based and we thicken it with coconut flour if we do it. And we use the actual uhm— turkey stock from the actual turkeys. That’s a huge way to get to the stuffing, I mean the gravy going. And then the stuffing there’s typically some good stuffing recipes out there where we do a celery and carrot-based stuffing and it’s totally grain-free and it taste phenomenal. So, off the bat, you can have your starches. I’m okay with that. Number two, you have the gravy. Because the gravy kinda goes on everything. So if your gravy isn’t too good, you can really mess everything up coz you just basically coating everything with thickened uh—turkey giblets and flour. And then uhm—then after that, you have I mentioned your starches and then after that you can do cranberry sauce, really, you know, super Paleo. You can do like, I’ll do green beans and I’ll cut up some bacon, I’ll layer that on there, too. Uhm—those are kinda my big things off the bat and of course, a really good turkey. We’re gonna smoke our turkey this year. We typically use our smoker this time of the year. Any other thoughts, Evan, off the bat for your? Just with the Thanksgiving Day meal?

Evan Brand: Well, my thoughts are you got me hungry but besides that—<laughs>

Dr. Justin Marchegiani: <laughs>

Evan Brand: But besides that, the enzyme piece.

Dr. Justin Marchegiani: Uh-hmm.

Evan Brand: You and want to talk about enzyme.

Dr. Justin Marchegiani: Yes.

Evan Brand: So let’s go into that. So one’s that you and I were talking about off-air was one from designs for health. It’s called allerGzyme. And this is more specific to people that if they’re just going to go off the rails, they are going to do or get it possibly get exposed maybe a cross-reactive issue with dairy or egg or soy or gluten or casein peanuts, things like that. You can take the specific enzymes. They’ve got like a patented version they call it what, Glutalytic in there.

Dr. Justin Marchegiani: Uh-hmm.

Evan Brand: It is supposed to be pretty helpful. And they’ve got bromelain. Way but it’s a very, very super high dose bromelain which is a pineapple enzyme. It’s a really good enzyme. So there’s that. And then you and I both have our own custom digestive enzyme formulas that I say those are the best nutritional insurance policies that you can bring with you like a little glass jar or something.

Dr. Justin Marchegiani: Especially the fact that people forget that I uhm— having a meal like that is gonna be stressful not necessarily because it’s bad because obviously we’re gonna try to make the substitutes. We’re not gonna focus on eliminating. We’re gonna focus on substituting.  So we have the most healthiest options possible but because we’re probably gonna eat such a ton of food, it’s going to be a lot for our digestive system to handle. So we’re gonna really utilize more enzymes and more HCl and maybe even some bile salts to really optimize our ability to actually break it down.

Evan Brand: Yeah. I love it. I’ve got a small little old honey jar that my wife just keeps in her personnel and so if we go out to restaurant or if we got to family member, I’m just gonna pull out those enzymes and popp them down. So that’s can be my strategy and I think everybody who is dealing with bloating, gas, indigestion, a lot of these common symptoms heartburn, you’ve got that excessive heaviness feeling.

Dr. Justin Marchegiani: If you already got those symptoms and it’s not even Thanksgiving yet, then you’re a person who needs extra care when it comes to using enzymes.

Dr. Justin Marchegiani: Absolutely. So we talked about the meal. We talked about maybe the potatoes and/or the sweet potatoes or the squash. I’ll typically put some extra cinnamon on my squash, too, which is great for blood sugar. And the blood sugar and the insulin kina receptor sites that which is good. I talked about the green beans. I talked about how to maximize the gravy because the gravy is one of those things that’s gonna be layered on everything. So if you can fix the gravy component— and we’ll have in the show notes some Paleo uhm— gravy recipes so we’ll make sure we get some Paleo recipes in the notes.  Uh—we’ll make sure we get some stuffing recipes. Coz those are gonna be the the big— the big things—the gravy and the stuffing. Almost everything else, you can dial it in. The turkey’s pretty good. You can do really good cranberry sauce, you can do uhm— squash, you can do sweet potatoes, you can do regular potatoes or any other sides that we’re missing.

Evan Brand: Yeah. You hit the green beans.

Dr. Justin Marchegiani: Yeah.

Evan Brand: Sometimes peas, sometimes carrots you.

Dr. Justin Marchegiani: Yup.

Evan Brand: I think honestly, if you’re eating real food and you just always think, “Am I eating real food?” you’re gonna be just fine.

Dr. Justin Marchegiani: Yeah. Then a couple of things—let’s go to desserts pretty fast. So we’re just kinda laying out the meal options or the meal substitutes, I should say, and then we’ll talk about little hacks that you can incorporate, too. So, off the, my Paleo Apple Crisp is something that I utilize a lot. I actually have it made once a week and it’s basically just a combination of the crust, which is gonna be coconut shreds, pecans and walnuts, kinda crushed up. And it’s gonna be kinda layered over some Granny Smith apples that are cut up. And the Granny Smith apples are basically mixed with butter. And they’re also gonna have a little bit of cinnamon on them and then we also have a little bit—

Evan Brand: I need this.

Dr. Justin Marchegiani: .. a little bit of organic palm cane sugar. And we like the organic palm cane coconut sugar because it’s got a glycemic index of 15. So it goes into your bloodstream a little bit slower and we try to use the least amount possible. So what I recommend is put the smallest amount whether it’s like uhm an eight of a cup or something in there. And just kinda glaze it and then mix it up. And then try a couple before you know, layer all the nuts and cook it. And then just see if it’s at the sweetness you want. So I don’t need a lot. I just put a very, very small amount. Once I have it, you know, typically, an eighth of the cup or sixteenth of a cup, a very—typically, I just glaze it. I don’t even h measure it. I just gently glaze it over so very small amount. And then once I have it to taste, then I pretty much put uhm—then it’s mixed with butter, of course, right? And then I put that topping right on top and there and then 350 for 30 to 45 minutes till the apples are nice and soft. And then you’re pretty much good to go.

Evan Brand: That sounds delicious. Did you invent that recipe or is that something you found?

Dr. Justin Marchegiani: No, I invented that one. That’s a good one. And then if you want mix it up, too, you want to make it more like a cake, you can do uhm—a tapioca and arrowroot flower and then typically you just add the arrowroot flour in with the apples, typically, half a cup to cup each. And then that kind of gives that more of a thickened flavor. And then you can just bake it not use the nuts. And then it comes more like a cake. And that’s a really good option. We have that Apple cake option on there, too. So, apple cake and/or uhm— the Paleo Apple Crisp. Apple crisp I think is a little bit more healthy coz you don’t’ have any flours in there. They’re all just a good healthy nuts and fats.

Evan Brand: Right. Yeah. I have a female client last week. She said she’s going to make a like a pumpkin pie but she’s going to do coconut flour and I think she said coconut flour and Coke and cashews maybe. So I know that there’s options out there. I just don’t eat too much dessert anyway, you know, besides a good piece of chocolate. But if you’re somebody who you’re going to go to one of these events and you think, “You know what I don’t want to miss out” Well then you just make it. You know, let  everybody else bring the meat and veggies. You just bring a healthy dessert. That way, you know that you’re gonna be safe and you’re not gonna cause yourself a flare-up or new problems.

Dr. Justin Marchegiani: Totally. For the most part, your turkey’s gonna be good, right? If you’re gonna do your mashed potatoes, fine. If you do cranberry sauce, if you’re gonna do squash, if you’re gonna do green beans or will do like uhm— Brussels sprouts with bacon, that’s typically gonna be good. You’re gonna mess it up with the excess uhm—gravy. So do the gravy right way and you do a healthy stuffing options. So I recommend is if you’re going somewhere, maybe you bring some gravy, or if you don’t bring the gravy, maybe you just uhm— bring the stuffing. And people won’t even know. We bring some of these healthy Paleo options we go places to get invited. People wouldn’t even know the difference a lot of times.

Evan Brand: Exactly.

Dr. Justin Marchegiani: The big thing is for me it’s about, it’s not about, “Oh, Dr. J, you’re being, you know, such uh—so tight about this. You know, why can’t you roll?” Well, the reason why  is I wanna feel freaking good afterwards.

Evan Brand: Yeah.

Dr. Justin Marchegiani: Yeah. I wanna eat a lot and I want to feel good. And there are great options and I don’t notice a difference in flavor. I can make my option and it will taste just as good. So those are some good options. Anything else you want—Oh, also dessert. Just, you know, if you’re doing a pumpkin pie, you can just leave out the crust are there some really good gluten-free, crust options or you can do coconut uhm— crust option. That’s fine. And you can just do your pumpkin pie without you know, just the lower amount of sugar. That’s totally good right there. Uhm— is or anything else you want to mention for desserts outside of the Apple Crisp?

Evan Brand: I think you covered it. I mean you could bring along a piece of dark chocolate if you’re just super scared and you don’t want to go for any of the more processed things. Bring a cup— bring a bar of dark chocolate with there on the fridge when you get to your family’s house.

Dr. Justin Marchegiani: Yeah. And again, you could do Pecan Pie a little bit higher in sugar. You just have to make sure the crust is gluten-free. That’s totally fine, too. And obviously, just some really good maybe some coconut ice cream, coconut vanilla ice cream’s totally cool. And then what about supplement options? So we talked about, number one, the enzymes, HCL and digestive support. Number two, you could always add in some activated charcoal.

Evan Brand: Yeah.

Dr. Justin Marchegiani: Activated charcoal. Number three, you could always throw in some probiotics later just to kinda help soothe and relax the tummy. Number four, well how about the approach like when do we eat the meals? So, number one, I recommend intermittent fasting and adding in some exercise in the morning. Even if it’s just a quick Tabata, or just a quick little weightlifting circuit where you kinda do upper-lower, upper-lower and just kind of a simple circuit for 15-20 minutes. Just something in the morning to really get the metabolism revved up. You may fast a little bit more. You may hold that fast a little bit longer than normal because you know that your gonna feast at the end of the day and all those calories will be coming in there to make up for that deficiency. Most aren’t gonna be working out on Thanksgiving. They’re gonna be relaxing and so it’s not as big of a deal.

Evan Brand: How about alcohol? You mentioned that off-air. You said we need to make sure we talk about that. So you’re recommending after meals instead of before meals saving?

Dr. Justin Marchegiani: Well, yeah, I recommend just have a little bit. Well, number one, there’s a couple of strategy. So I may do one glass just to kinda get that buzz in my system fast. It’s like, “Ooh, I could feel it.”  And then I’ll throw maybe a couple of things, a charcoal in, and then maybe there will be like a shrimp cocktail out and have a couple of little shrimps just to kinda get the protein, fat in there which kinda stabilizes my blood sugar level a little bit more so I’m not gonna go wonky. And then I typically just go with like a dry champagne or a dry Prosseco. So it’s very dry kind of a demi-sack, not a lot of sugar white and I like the sparkling. The sparkling has been shown to increase alcohol absorption. There was a—one study out of a bunch of college students. Can you imagine that? I would love to have been in the study in college where they gave them shots of vodka and then the other group got shots of vodka with carbonated water or like soda water. And they measured their blood-alcohol content and they found that the group that had the bubbles with their vodka had a much higher blood alcohol content for the same amount of alcohol. So, go figure. So what’s the moral of the story? You get— your alcohol goes for little bit longer of array when there’s little bit of carbonation or, bubbles in there. And James is saying, “What about Cheetos?” Yeah. So I would do Cheetos with my ginger Kombucha and a little bit of lime. The lime provides extra vitamin C, which is great for glutathione. The Kombucha has extra B vitamins and antioxidants and EGCG in there and uhm—probiotics. So it actually helps detoxify and help your gut microbes while you get a little tipsy.

Evan Brand: See that almost makes me wanna drink alcohol but every time I drink alcohol, I feel like I can’t comprehend simple things, like I like to I like to always have my brain going going going.

Dr. Justin Marchegiani: Totally.

Evan Brand:  And for me to shut off with the alcohol, it’s almost stressful. It’s almost like, “Nope, my brain is slowing down.” I don’t like this.

Dr. Justin Marchegiani: Well, we should make sure the demand on our brain is less.

Evan Brand: Right.

Dr. Justin Marchegiani: When the time—we’re not gonna be like opening up the champagne bottles when we’re seeing patients, right?

Evan Brand: Right.

Dr. Justin Marchegiani: We wanna make sure our patients get a 100% of our brain capacity. But when it’s the holidays and we’re just watching some football, and our brain is like 80% off, maybe it’s not that big of a deal.

Evan Brand: <laughs> For sure.

Dr. Justin Marchegiani: Yeah. But, yeah, we have the activated charcoal. We just have really good quality alcohol. Uhm— again, why does it matter? Coz I don’t want a headache. I don’t wanna feel crappy. I don’t want a ton of breakouts the next day. So we’ll choose uh—and typically, I’ll just get $15 bottle of really good dry Prosseco from Whole Foods. And I try to, you know, if I can go organic or you know, typically, the dryer ones are not gonna have as much sugar. It’s the sugar that’s gonna really throw you off. Uhm—you can also do the dry Creek wines. They have some decent stuff. Again, they don’t have a lot of bubbles like a lot of spike, Prosecco, I do that because number one, it helps with alcohol absorption. Number two, I just like the bubbles.  They don’t have a lot of options with that. So I will check out some of the whole foods or local stores, they have a very low sugar like as for a brewed or a Demi-Sec uhm—Prosecco option.

Evan Brand: The holidays are fun.

Dr. Justin Marchegiani: They are. Absolutely!

Evan Brand: I think our next month of episodes is probably be silly. It’s coz that’s the that the holiday vibe. It’s relaxing. It’s like, you know what, the summer time things have cooled off. It’s time to relax, time to rekindle, time to cuddle up, snuggle under your wool blanket next to a fireplace. This is a good time of the year.

Dr. Justin Marchegiani: I got a fireplace in my office so it’s actually nice coz I actually get to use it this time  of the year, so—

Evan Brand: That’s awesome.

Dr. Justin Marchegiani: So my dog just like—it’s basically a magnet for my dog. She just kinda—next to it all day. But, yeah, totally. And then uhm—you mentioned a couple things there. We talked about the alco—so yeah, really getting the exercise component going. Coz that really is gonna wring out a lot of the glycogen in your muscles. So think of glycogen as stored carbohydrate in your muscles and imagine you wringing that muscle out. You’re wringing that sponge out so all of that water in the sponge, all that glucose stored in the muscle now gets used up doing the exercise. Now what does that do? It’s like, well, it’s the equivalent of going and having a nice dry sponge to sop up a whole bunch of liquid drink that your kid knocked over, right? So you can just— that sponge is gonna work a lot better and be more absorbent. Think of your muscles as being more absorbent. So when you get extra carbohydrates into your uhm— body from your meal in your celebration that you’ll have a bigger sponge to soak it up.

Evan Brand: That’s a good idea. I don’t know if many people act on it but if they do, they’re gonna see a really good result. Here’s a question for Mike. He says, “It’s crazy. My Oura ring consistently shows my sleeping heart rate 5 to 15 bpm higher even after having just two drinks like red wine. I feel it the next morning. Any suggestions?” Justin, I know what you’re gonna say. Go ahead.

Dr. Justin Marchegiani: Well, alcohol can drop blood pressure. So it could be your blood pressure is lower than your heart has to be a little bit faster the compensate for that drop in blood pressure. That’s probably what it is.

Evan Brand: So you’re thinking maybe you don’t need suggestions. So I thought you might say, “Oh, just are you doing charcoal? Make sure you do charcoal.”

Dr. Justin Marchegiani: Of course, right? Like of course, extra charcoal. We can always throw some vitamin C in there, add in L cysteine. And we could even throw in, yeah like in our lines, we can throw in some detox aminos which is kind like your sulfur base, kinda NAC with a whole bunch of other sulfur amino acid in there. That— that’d be fine. I mean, I would do that. You can also throw a little bit of magnesium in there to uhm— to help with the with that component. But uhm—yeah, I would just look at potentially that just being the alcohol and just do all the things that help detoxify.

Evan Brand: Okay. Cool. Awesome. I think that’s everything we’ve hit. I don’t know if there’s any other piece to the holidays you wanted to go over.

Dr. Justin Marchegiani:  Yeah. I would try to time off like for me, I notice if I have felt any alcohol in my system when I go to sleep, I do not sleep nearly as good so I tried to give myself like a good three-hour washout period before bed. So I don’t have you know a lot of alcohol in my system. I just don’t sleep as good. I literally have more nightmares, I’m more active, I move around the bed a lot more. I had a glass of champagne before bed like a week or two ago and I like literally woke up at a right angle. So I was like laying across the whole head. I’m just way more active. Normally, I don’t move much at all. So again, if I I had that like at seven and I went to bed at like 10, it wouldn’t be a problem. But if I’m having it right up against bedtime, sometimes it could be the__ plus you know, I’m— I don’t know what the alcohol is when I go out if I order it. I try to order, you know, a nice low sugar kind but you have the bottle in front you look at it, so you just try to go off the waiter’s suggestions.

Evan Brand: Exactly. Yeah. I think it’s all good advice the liver-gallbladder support. I mean, that’s always helpful, too. So if it’s milk thistle or if it’s your Cordyceps mushroom. I mean there’s a lot of different products we use for for liver gallbladder support. One of the thing I was gonna mention, too, make sure that you check in with your practitioner if it’s Justin or myself. If you’re taking anti-parasitic herbs, some of these herbs can get intensified with alcohol. So one glass of wine may feel like four. You may not be able to make it home. See—take a  look and see what you’re actually using. I know some of these can create that sensitivity up.

Dr. Justin Marchegiani: Totally. Any other suggestions just like meal wise or anything that you guys are doing with your family for the holidays?

Evan Brand: I’m gonna bring some snacks just in case. I mean we don’t know the full spread coz we’re gonna go to like three or four different events.

Dr. Justin Marchegiani: That’s tough.

Evan Brand: ..this week and we don’t know exactly what people are cooking, what people are bringing. So just in case, I’m just gonna go ahead and bring uh—I’ve got a couple of some jerky like some jerky strips like some grass-fed steak strips that I’ve got and then I’ve also got a handful of macadamia’s of customer cons would also have coconut chips so I’m just gonna bring some snacks just have that in my wife’s purse just in case just in case we get somewhere and it’s just— I have been to a couple events where it was literally like a casserole, it was covered in cheese and that was the only—that was like the main entrée. There’s no way I could do this.

Dr. Justin Marchegiani: Totally.

Evan Brand:  Like you know, with enzymes, I’d be destroyed so uh—that’s— that’s about it. Just be prepared boy scout. Act like I was going to place that had no food.

Dr. Justin Marchegiani: Exactly. And again, there are some people out there where they may be really happy with her health right now. They’re just like, “Hey, this is a once a year thing and I’m just gonna cheat and really enjoy it. And that’s fine, too. But you know, still you can utilize some of the supplements and strategies we recommended so you at least doesn’t hit you as hard. And if you want to wreck if you want to apply some of the substitutes that Evan and I apply, and I’ve done it for years that in my opinion allow me to continue to feel good. I just— for me, it’s not just feeling good that day. I got four days off  work. I don’t take a lot of time off. I wanna feel good for those four days and I also don’t want to get sick either.

Evan Brand: Yup. Exactly.

Dr. Justin Marchegiani: Well, any other thoughts, Evan?

Evan Brand: I think that’s it.

Dr. Justin Marchegiani: So any other plans for you this week? Are you taking some time off from patients or—?

Evan Brand: Yeah. So Thursday, Thursday- Friday I’ll be taking some time off. My wife she’s can go out and participate in the consumer holiday on Friday. And I think that’s about it. I’m gonna try to spend some time out in the woods. I may— I may go out and and go for a deer hunt again. I want to get my own dear this year. 99% of it is just sitting out in nature listening to the birds but may be .01% of the time an animal walks by.

Dr. Justin Marchegiani: Totally.

Evan Brand: Really, it’s just my excuse to go do some forest bathing. I may try to do that.

Dr. Justin Marchegiani: What’s the Japanese term for that?

Evan Brand: Shinrin Yoku.

Dr. Justin Marchegiani: Shinrin Yoku. I love that, man. That is crazy. Cool. And we also add another herb to our parasite killing line, too. The mimosa Pudica. So I know will be adding that to our stores in the next week or two. It’s one of those things that we are kind of experimenting with. We’re helping to kill bugs and some of the wormies. So it’s something out there that if your patient and you want to inquire about that, we can chat about that very soon.

Evan Brand: Yeah. Stay tuned. I’ve gotten many, many pictures in my inbox of worms that people are pooping out from using this Mimosa Pudica. I was just a guest on the parasite summit, which is how I learned about this formula. And tons of people are taking it now and everybody’s saying, “Oh my God! My stool test showed up negative but I took this stuff anyway. And here’s what I pooped out. Surprise!” And it’s pretty nasty stuff. So Justin and I are talking off like, “Are you going to try some of the stuff?”  I’m guessing we’re gonna have to because we’ve been guinea pigs for everything else. So, who knows if we’ve got some hidden—

Dr. Justin Marchegiani: Absolutely. Well, what a great call today here, Evan. Happy holidays and Happy Thanksgiving for you and your family. And we’ll talk next week.

Evan Brand: Take care.

Dr. Justin Marchegiani: You, too.

Evan Brand: Likewise. Bye.

 


REFERENCES:

Justin Health Paleo Apple Crisp

https://justinhealth.com/products/detox-aminos/

http://catalog.designsforhealth.com/AllerGzyme-60_3

http://www.drycreekvineyard.com/

Depression Solution – Dr. J. Live Podcast #158

Dr. Justin Marchegiani and Evan Brand talk about depression and anxiety. Listen as they discuss some of the possible root cause of such condition. Understand the mechanism of depression and anxiety medications and learn why they may not be the best possible solution to the problem.

Gain an understanding on how diet, especially a vegan diet, becomes an important factor when dealing with depression. Explore how gut infections relate to depression and anxiety symptoms and know some of the natural solutions and recommendations in addressing depression and anxiety.

In this episode, we cover:Depression and Anxiety solutions

00:56   Medications mechanism

03:40   Vegetarian Diet and Depression

05:41   Gut Infections and Depression

14:00   Natural Solutions

18:18   Low Thyroid and Mood Issues

 

 

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Dr. Justin Marchegiani: Hey guys! It’s Dr. Justin Marchegiani here. Hey Evan, how are we doing today, man?

Evan Brand: Hey man, I am great. We had a fun off-air chat. So I’m excited to chat with you about this important topic today— depression, anxiety, you know, mental health in general. But we’re gonna—

Dr. Justin Marchegiani: Uh-hmm.

Evan Brand: ..specifically focus on depression, anxiety. As I was telling you, the center for disease control, they change the ranking over the past couple years. Now depression is the number one leading cause of disability. It’s actually grown over heart disease. It used to be heart disease was number one. Now depression is number one leading cause of disability. So that’s pretty alarming. I predicted this about four- five years ago I could just see the trend of society and now, it’s happened and it’s official.

Dr. Justin Marchegiani: Totally. Depression is really important because a lot of the medications that are out there. I’m just gonna pull out my little Bluetooth headset here—all the medications that are out there, typically, only treat the symptoms. So you kinda have medication from like the 80’s called tricyclics, right? And these tended to—to work with a little a side effects that a lot of the current days SSRI’s or SSNRI’s, right? These are medications that work on blocking the reuptake of serotonin and norepinephrine or dopamine. And essentially it’s allowing more neurotransmitters to sit in between the pre- and the postsynaptic neuron. So neuron—neuron, pre-post- right? Before, after and then you have all this in between area called the synaptic cleft or the uhm—essentially that’s where a lot of the neurotransmitters would hangout. The longer those guys hang out in that area, typically, what happens is you’re gonna have uhm—a recycling of those neurotransmitters at a higher level. So the longer those neurotransmitters sit in that neuro- synaptic cleft there, the faster they get broken down. So that’s why over time, a lot of antidepressant medications have to go up because of the fact that those met—those chemicals are being broken down at a much faster rate. Does that make sense?

Evan Brand: Yup.  Well, the problem is, too, these medications they’re not addressing the root cause now. I know in some cases, they could be life saving therapies because they pull people out of a super deep depression or maybe they were suicidal. But as time and time goes on, the percentage used to be 80% of serotonin was coming from the gut and then it jumped up to 85 or 90% and then now, I keep seeing new literature coming out that the percentage is almost close to hundred percent now of serotonin from the gut. So we really have to address any gut infections we have to test for those, we have to find them, we have to fix them. If we really want to get to the root cause, the brain, of course, is a factor, but man, the gut seems like the biggest factor to me.

Dr. Justin Marchegiani: Oh, it’s a major factor. And again, uh— one of the listeners here in the live chat brought up a lot of the shootings that have been happening recently. Yeah, these medications have a black label-warning, black box warning on them for suicidal tendencies, violent acts, these kinds of things. So it can really alter someone’s physiology and biochemistry were it may predispose them to—to these kind of violent act. So, again, I look at these type medications really only being used in a life or death kind of, “Hey, we’re gonna get this person stabilize so that  they don’t do something that they’re gonna regret.” But then we have to work on getting them off these medications and get to the root cause.

Evan Brand: Yup. Well said.

Dr. Justin Marchegiani: And that really has to be the end goal. We need to have a transitional goal in mind so we can get to the root cause whether we start adding in specific amino acids, amino acid therapy. A lot of these neurotransmitters they come from amino acids. So there’s kind of just like the replacement model of, “Hey, let’s add more amino acids into buildup serotonin and dopamine in the brain so you feel better.” There’s that component, right? And that may be really important especially if you have a lot of malabsorption, like you’re not breaking down proteins and fats, you have low stomach acid or enzymes. It may also be important like you’re a vegetarian or vegan and you’re not getting enough of these high-quality proteins and animal source which tend to be the most nutrient dense. So there’s a lot of different things that may drive that from an amino acid perspective. And you talk about 90+ percent in the gut. The question is, “Can that serotonin cross the blood brain barrier?” I’m not sure we know if it can. From what I understand, it can’t. But uhm—a lot of the precursor amino acids like tryptophan, and/ or 5-ACP can cross the blood brain barrier.

Evan Brand: Uh—got it. Okay. I guess, so you brought the vegetarian/vegan point. This is huge. You and I both work with so many vegetarians and vegans and sometimes, they’re just not willing to add-in things to the diet. So whether it’s like egg or even fish, they just don’t want to add it in. And I’ve seen the most depression anxiety problems from vegetarian and vegan. So I wouldn’t even say it’s like just a coincidence anymore. I mean I’ve seen it so often that it’s just—it’s it’s— gotta be causation in this— in this aspect.

Dr. Justin Marchegiani: Well, you’re gonna always get higher quality amino acids, proteins from animal products. It’s just how it is. Uhm—you’re not to get a whole bunch of anti-nutrients with them, right? The way animals defend themselves with teeth and with claws. The plants defend themselves are with anti-nutrients, compounds that make it harder to break down uhm—their constituents. The lectins, phytates, mineral blockers, anti-nutrients. They make it hard to break down some of these plant. That’s how plants kind of survive, right? Animals survive through uh—claws, and being able to run, fight and flee. But once you have an animal, right? Once you already killed it and you get that meat in the table, it’s not gonna  possess the same amount of anti-nutrients. And it tends to also have just pure protein and fat where a lot of the plant-based proteins are gonna have a whole bunch of carbohydrate along with it. Unless you’re doing like a pea protein powder or rice protein powder where the starch component has already been removed from the proteins.

Evan Brand: Yup. Yup. Well said. Uhm—let’s talk about some of the gut infections. How this could relate into depression, anxiety symptoms. We could talk about H. pylori. We had a question about that, too. So, we’ll go ahead and address it. How can H. pylori cause depression? We know that it’s gonna reduce stomach acid. If it’s reducing stomach acid, even if you are eating those good quality organic pastured animal proteins, you’re not gonna digest those. So you’re gonna have undigested food particles creating the leaky gut situation that can stress out the liver. We know there’s a link between mood issues and the liver. Sometimes it’s fatigue, sometimes depression, sometimes anger, irritability uh—things like that. And then you’ve got the aspect of the aminos. So I just already hit on. If you’re not digesting these proteins, that first domino could be affected all because of your low HCl production due to the H. pylori then all the sudden, you have no amino acids. Now, you’ve got no raw materials to manufacture neurotransmitters. So this is huge.

Dr. Justin Marchegiani:  Hundred percent. So—so there’s a couple different components, right? Dan writes, “Can H. pylori cause depression?” Yeah. Well, number one, it’s gonna do it by a couple different ways. Number one, it’s gonna lower stomach acid and enzyme levels which make it harder to break down proteins and healthy fats which you know, fats tend to be a really important building block for the brain. And the proteins tend to be the building blocks for the neurotransmitters. So if we have decrease in the raw material of the brain, right? And we have decrease in the neurotransmitter raw material, then we’re gonna have issues with optimal mood health, for sure. Number two, is a lot of the uhm—bacterial components of H. pylori have what I call lipopolysaccharide or endotoxins, which can cause depression by itself. It does it through going to the brain and creating inflammation to the brain. It passes through the gut junctions, creates leaky gut, goes to the brain creates inflammation and create mood issues in the brain. It also can uhm—it also can just create leaky gut and which can increase the immune system. And when the immune system is kinda over reactive, it  can suck up a lot of energy. And when your energy is lower, it tend to have more likelihood of being depressed and being anxious. Typically, lower energy and depression tend to come hand-in-hand.

Evan Brand: Yup.  I had H. pylori have multiple parasites. So we had a question from Dawn. He was asking what parasites are the most destructive and what parasites would cause the most amount of depression. I don’t know if we can rank it like that 1-2-3. Number one is gonna cause the most depression but I know when I had Giardia and I had cryptosporidium, I had weight loss, I had H. pylori, I had fungus, I had Candida, I had SIBO, you know, pseudomonas and bacterial infections. I was just very, very, you know, not right in the head. My sleep was off which then affect my energy, which then affected my mood. So it’s hard to say like was it chicken or egg. These parasites cause depression or was it the fact that my sleep was disrupted, therefore I wasn’t actually waking up rested. And that made me tired and depressed. Uhm— Justin, do you have any comments to add about that, like parasites, could you rank them at all, saying crypto or Giardia’s worst than dientomoeba or blasto in terms of the amount of depression it creates?

Dr. Justin Marchegiani: Well, I would definitely say you—your parasites that are tending to cause more problems because they tend to be a little bit more endemic. They tend to cause more information. But regarding in which ones, it’s hard to say. I’ve seen people have other parasitic infections that cause more problems uhm— than what they typically say on paper. Like some people have uhm— Dientamoeba fragilis but that’s typically one that may not cause a lot of symptoms. So the question is, well, why did it cause a lot of symptoms for you and not the other person. So, again, things like histo and crypto, it tend to cause more problems, but sometimes you may have a less virulent type of parasite infection and it may cause just as many issues for you. So the question is if you have an infection and you have symptoms, especially if you have  an infection and you have digestive symptoms, we got out work on getting the digestion better and then fixing the infections next.

Evan Brand: Yup. Well said. So we have a question about “Is it possible to for your partner to give you a parasite or if it enters your body while your system fight it off?”  The literature is not clear on parasitic infections. Now Justin can tell you about like some of the correlations we’ve seen where partners have infections. We know 100% H. pylori is passed all the time. 90% of the time, I have someone that shows up with H. pylori, the spouse eventually has to get involved. We have to get them tested and we end up having to create a protocol for them, too, because I’ve had people where we create a protocol, the H. pylori’s gone on the retest of the stool and then the symptoms come back a few months later. We do another stool test, then all of a sudden H. pylori’s back again like what the hell happened. Typically it’s the partners. So then we have to get the spouse, boyfriend, girlfriend tested. They usually are the source and also we create a protocol for both of them and all of a sudden they get better. Now parasites, though, I don’t know. Justin,  what’s your thoughts on passing all the parasites you know, kinda back and forth between each other? What have you seen?

Dr. Justin Marchegiani: Yeah. I think that’s a 100% probable. We see it a lot with our chronically ill patients that tend to get reinfected over and over. That’s a factor that we always look at to make sure we get the partner, the spouse addressed coz you can definitely pass it back and forth. And I’m more worried about the inflammation, I’m more worried about leaky gut, I’m more worried about the LPS and the endotoxins making the way to the brain and creating inflammation and symptoms there. I’m also worried about just of the maldigestion, not breaking things down well not having enough stomach acid, enzymes, bile salts. So just affecting the digestion, number one. Affecting the leaky gut, number two. And then eventually making its way to the brain. Leaky gut will also cause leaky brain and that could also create more symptoms as well.

Evan Brand: Yup. Well said.  I mean the leaky brain thing, most people don’t talk about it. I think we’ve— we’ve hit or— we’ve hit on that topic on many episodes but I don’t think we’ve done a full one. So maybe we should add that to the list. The whole leaky brain episode. But, people, you do want to realize, if you have leaky gut and this could just be caused from non-celiac gluten sensitivity. If you’re eating gluten, we know that’s creating the leaky gut situation. That’s creating leaky brain. If you take a GABA supplement and you get relaxed from it, you have a leaky brain. And that’s not good. Because then you’re sitting in traffic, you’re breathing in diesel fumes and other pollutants. That stuff is having direct access through the blood brain barrier, which normally would protect you so that the integrity of that barrier is super important. Uhm—there’s another question here about depression. Could it be caused because of a lack of dopamine? Is supplementing with tyrosine sufficient enough to help depressive moods? Yes and no. The thing with the amino acids is it’s like a spider web. So if you do start modifying serotonin, things can get messed up with dopamine. If you just start pounding L-tyrosine, that doesn’t necessarily mean that it’s gonna fix your problem either. So, really, you wanna get organic acids test first and figure out what’s going on coz we can measure dopamine. A lot of people think they have low dopamine but it’s actually too low serotonin or some people have low serotonin and they think that it’s that. But it’s actually not. It’s actually low dopamine instead. So, vice versa. I hope that made sense. But across the board, you could be low in GABA, you could be low in your catecholamines, you could be low with your norepinephrine, epinephrine, you could be lower cortisol. So even cortisol can be a component of depression because if you’ve got adrenal problems, that cortisol rhythm is too low, your batteries aren’t charged or you’ve got too high cortisol, or your cortisol is all over the place fluctuating high and low, which could all be due to these infections. That’s the perfect recipe for depression. So tyrosine may or may not be the solution for you.

Dr. Justin Marchegiani: Totally. And I have one article here. It talks about dietary proteins having a substantial effect on the composition of gut bacteria. And they talked about for instance, suggestion of intake of dairy and meat protein at recommended level may be beneficial to maintain balance composition of gut bacteria compare with soy protein. Now, again, some of the studies are rat-based so it’s not gonna be a direct correlation, but having a healthy gut bacterial level may decrease some of that gram-negative bacteria which is some of the not so nice uhm—bacteria that tend to cause more of the LPS, right? The lipopolysaccharide and endotoxin. So if we can get the gut bacteria more in the balance, that may decrease the LPS, help with healthier gut integrity, help with less LPS getting into the brain, which creates a mood issues that way, too.

Evan Brand: Yup. So did you want to go into some of the natural solutions now? I mean, we’ve hit on neurotransmitters a bit. We hit on infection, so finding and fixing those. What about some of the free stuff, like just exercise alone just increasing BDNF, getting the movement, getting the blood going. I mean that’s huge.

Dr. Justin Marchegiani: Totally.

Evan Brand: I mean exercise has change my life.

Dr. Justin Marchegiani: Yeah. I would say that the BDNF, the Brain Derived Neurotropic Factor really helps with mood, helps with healthy, uhm— myelination, improvement of brain building uh—keep staying away from grains is really important because that can decrease blood flow up the garden hose. It’s called the carotid artery to the brain. If we decrease blood flow, we’re gonna, one, not be able clear out inflammation as well. We’re also not gonna be able to bring oxygen and nutrition to help the brain, too. So gluten is a big one. I would say, of course, your amino acid, serotonin 5 HCPL tyrosine, of course, B6 is really important. And if we’ve got bacterial imbalances that will affect B6. Also, healthy probiotics can help with gut inflammation. Remember inflammation in the gut will create inflammation in the brain. So healthy levels of Lactobacillus, bifida bacter, probotics will help cool down inflammation in the gut, which may help decrease some of that that glial site activation in the brain, which again is—is an inflammatory cell in the brain. It’s a white blood cell that it’s in the brain called the glial cells and when those get activated, it can create uhm—brain fog and it can also create mood issues, too.

Evan Brand: Oh, I wanna go back to the diet piece. So there is a piece of literature out there, a study of 9,700 vegetarians including some vegans, they were twice as likely to suffer from depression as meat eaters even after adjusting for variables such as job status, family history, and number of children. And then it goes on to talk about the lower intake of omega-3 fats, B12 and folate, which all can affect depression risk. Uhm—so on that note of the Omega 3’s, yeah, DHA, fish oil supplement could be helpful, but also, you’ve got pastured meats. You know, grass-fed beef alone contains so much more Omega threes than your standard typical low-quality meat. So, that is a really, really good piece of the puzzle.

Dr. Justin Marchegiani: Yeah. Uhm— definitely getting 3 to 4 servings, 4 ounces of healthy fish per week is gonna be great, wild Alaskan, sockeye, skipjack tuna, you know, kinda  high selenium to low mercury type of fish. You can just google that, high selenium to low mercury fish. It’s typically the higher ones are gonna be like the uhm— the shark pilot whale, those things, swordfish are gonna be much higher in mercury to selenium. Skipjack’s gonna be great. Wild Alaskan sockeye is gonna be great. Cod, Haddock, Sole. These are all gonna be higher selenium, lower Mercury. That’s great. And if you want to be on top of it more, you can do your 2 to 4 g of fish oil per day is excellent. That will have EPA and DHA in it.  You know the ones like my Omega supreme has lipase in it. It’s also a triglyceride form, so it’s better absorbed, number one. LS oxidation, number two. And then the actual lipase will help you break it down in case there’s some fatty acid, you know, the digestion uh— digestive compromise things going on in there, too.

Evan Brand: Yeah. Well said. If you’re buying fish oil supplements, people, if it smells fishy, throw that stuff out. It’s garbage. It’s ethyl ester form. If you go to Target, Walgreens, uh— any of these big box stores and you’re buying fish oil, it’s crap. Do not waste your money. Buy professional grade supplement. Check out Justin’s site, justinhealth I’ve also got one, evanbrand Just look us up. Find our stores. And we’ve got good fish oils because if you’re not doing professional grade, you’re wasting your money and there’s actually literature now that if it is an oxidized rancid fish oil, you’re actually creating more inflammation when the whole goal is to suppress inflammation and help depression. You’re making it worse if  you’re doing the low-quality like a Kirkland’s or a Costco or Sam’s Club or these big box uhm—fish oils, vitamin Shoppe, GNC. All those guys. That’s all consumer grade. It’s all ethyl ester. That’s not good. You want triglyceride.

Dr. Justin Marchegiani: Exactly.  And Teresa mentions a low T3. So if you have low thyroid levels, poor T4 to T3 conversion, right? Or lower thyroid or active fiber hormone T3 or tri iodo thyronine, that’s important. Low thyroid can create mood issues. It can create depression. So we’d want to get to the root cause of why the thyroid is low. It could be just a combination of an autoimmune issue driven by gluten and other infections it could be a nutrient conversion issue like selenium and vitamin A, copper, zinc, magnesium. It also could be uhm—you know, gut bacteria issue. It could also be a stress issue like cortisol, right? So adrenal function has major effects on mood, too. If the adrenals are hyper or hypo functioning, there could be some mood issues there. It could be fatigue, it could be anxiety, it could be depression, it could be a combination of all three. Typically, anxiety and depression tend to come together. Some people can have them just individually where they are either anxious or depressed. But some people they tend to ebb and flow between the two.

Evan Brand: Yup. Well said. So if you have thyroid problems, you’ve got to investigate the gut, you’ve got to investigate the adrenals. We talk about that, but we can never stop talking about it because your conventional doc is not bringing this up. When you go there and you show up slightly off with your TSH, they’re not gonna say, “Hey, maybe you have gut infections. It’s causing conversion problems. Maybe you have adrenal problems that’s messing up your conversion of active thyroid hormone.” They’re not gonna say that. So we have to keep talking about it.

Dr. Justin Marchegiani: Hundred percent. And so outside of that, yeah, Tessa makes a note,
“Hey, I don’t have a  thyroid.” Then you really have to make sure you’re on a full-spectrum thyroid glandular and your T3 levels are at a therapeutic level, at least above 3.0 for T3 free. Ideally, I’ll make sure T4 is above 1.0  That’s a really good starting point. And then James mentions, “What about Olympian labs omega-3 fish oil?” I’m not quite sure. It could be good, it may not. Typically, you get what you pay for. Number one, you want to make sure it’s a triglyceride form. Number two and ideally you want to make sure it’s in, you know, this is like a plus, like I , add in the lipase coz I have worked with a lot of patient that have compromised guts and I want to make sure they can break the fish oils down well. So that is another important component.

Evan Brand: Yeah I’m looking at it right now. I can’t find any information about whether that brand is a triglyceride form or not. So I’ll keep digging and see if I could find it. But, Justin and I were biased because we want people to get better. We have to actually follow up with our clients and speak with them. And if they’re not getting better that comes back on us. And so we really want to use and we always use the highest quality professional grade formulas, which tend to have tighter quality control and better certain—

Dr. Justin Marchegiani: And also just better potency, too. I remember  I had some issues in the supply chain because some of the nutrients that we were getting, were testing positive with some—some metals and some other not—not so nice compounds. So they sent it back to the manufacturer. So the nice thing is we’re always trying to look and make sure there’s no other contaminations where let’s say a lesser quality company may just say, “look the other way and just let it go.” So we’re trying to put that quality control on it to ensure that there is not to be any extra crap in it that could throw you off, so to speak.

Evan Brand: Yes. So I ended up on the Olympia labs website here for this fish oil. It looks like and this is just to cheap, right? So if you see something for 30 bucks for a 120, that— it just sounds too cheap already. So to me, that tells me not gonna be triglyceride form. I read the entire description. I don’t see one word that includes a triglyceride form. So to me, it’s ethyl ester. You could always contact them and say, “Hey, is it up ethyl ester triglyceride?” But I’m gonna bet a hundred bucks that it’s gonna be ethyl ester which is inferior. You don’t want to put that in your body.

Dr. Justin Marchegiani: Absolutely. But again, if you’re doing three or four servings of 4 ounces of fish a week, you may not even need fish oil. Uh—again, if you have extra inflammation, or extra brain stuff going on, cognitive stuff, mood stuff, then I would recommend supplementing it. Just so you get extra bit on top of it. Just to ensure that you know, what you’re getting is getting to where it needs to go. Is there anything else you want to add, Evan, about depression or mood stuff regarding functional medicine here?

Evan Brand: I think that’s it. We hit the gut, we hit the adrenals, we hit the thyroid aminos, liver function, digestive, anti-inflammation. I think we’ve hit all, man.

Dr. Justin Marchegiani: Awesome. Well, hey,  great talk today. We’re doing some quicker podcast so we can get more content out there to everyone. Hope you appreciate it.  If you enjoy it, give us a thumbs up. Subscribe. Click on the bell now. With YouTube, they make it so you don’t get a lot of the notifications of new videos and new content unless you are subscribed and you hit the bell. So click on that bell. Do it for Evan’s channel as well and myself. That way, you can get all this really good spoon-fed information for you guys to continue to improve your health and your friends and family health, too.

Evan Brand: Yup. If you need to reach out for a consult with Dr. J or myself, go to Justinhealth.com Evanbrand.com You can schedule consult with this. We’ll help you via phone and Skype. We work with people worldwide. We’ll help you get tested, get to the root cause. So look us up. Book a call if you need help. Don’t try to piece it together for suffering. We’re here for you. So have a great day. Take Care.

Dr. Justin Marchegiani:  Thanks, Evan. Take Care.

 


References:

Justinhealth.com

Evanbrand.com

 


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