Post Viral Immune Support To Improve Energy | Podcast #363

What you eat after a viral infection, when symptoms of fatigue persist, can have a marked impact on your speed of recovery. Dr. J and Evan discuss that specific foods need to be avoided or included in your diet to improve your immune system. So what are the truth and the evidence about diet and post-viral immune support?

The good news is that most people will benefit from some considerations when recovering from illness or infection. Having post-viral fatigue means that you will not have your usual energy to think, shop, prepare or eat as before. Be very practical and kind to yourself. Dr. J and Evan added that diet modification is vital in your recovery.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

0:00 – Introduction
1:57   – The role of acid-pH level in the digestive system
5:01  – The link of depression and anxiety to bloating
10:02 – The benefits of probiotics and effects of stress to digestive health
18:17 – Functional medicine strategies and testing to find the root cause of bloating

Dr. Justin Marchegiani: And we are live. It’s Dr. J in the house with Evan Brand. Evan, how you doing man? How are your holidays? How’s everything going brother?

Evan Brand: Everything’s going pretty good. I’m trying to start 2022 off with a bang. I suspect it’s gonna be a better year than 2021. People are becoming smarter. They’re becoming more educated. They’re becoming more resourceful. People are waking up. There’s a lot of, we’re in the great awakening and so I think, this is an important time to be alive and an important time if you’re a parent, if you’re a husband, a wife, if you’ve got kids, if you’re a teacher. It’s important time to keep your eyes open and keep your ears to the ground because stuff changes quickly and you got to be like a little speedboot. You got to be able to take turns quick, you don’t want to be the titanic right now, you don’t wanna be slow in taking big turns, you gotta be nimble in these times and so what I’m alluding to is just you got to be able to navigate the world of health which is quickly evolving and that’s true. What we’re trying to talk about today is post viral fatigue and really that’s just the title but this really could apply to bacterial infections and parasites and mold exposure but we just wanted to try to zoom in a little bit specifically on post viral fatigue and things like Epstein Barr virus, many people are familiar with and there’s a lot of people that report their chronic fatigue, picking up after something like EBV, we’ve seen it a lot with the virus going around now which would probably get flagged and censored so we won’t say it but you know what it is and there’s a lot of post, uh, viral fatigue going on from that and so you and I have dealt with some of that, you’re still going through the thick of it right now but I think you’re coming through pretty well, you’re still working and obviously you’re on your feet right now literally standing so that’s exciting and yeah.  

Dr. Justin Marchegiani: For the listeners, I had COVID last week, actually symptoms started on Wednesday. Really two hard days of symptoms, I was able to work the whole time though, I mean I think that the symptoms for my COVID that were, um, tough was I would say achiness and then like sensitivity to cold like it was like 45 degrees out and it felt like it was minus 10. So, I would say sensitivity to cold and then also getting really hot at some points, getting out where I would sweat through my shirt. So hot and cold, achiness/ headaches and then like easily out of breath but I mean for me I mean, it was still fine where I could work and still do the things I had to do. So it wasn’t that bad, I mean, I had a flu in 2013 where I was literally laid up for over two days and I couldn’t do anything so I know laid up feels like it wasn’t even close to the flu of 2013 for me, that was really hard. So, definitely, um, not as bad, I actually was my own worst enemy because on Friday I was feeling like really good like 80-90% better and did like 2-3 hours of housework like cleaning my house like doing all this different stuff because it was a beautiful day and I’m like all right let me get on top of some work, work 3 hours probably walk like 15,000 steps and that next day there was a major relapse in how I felt. It was probably like I went backwards 30-40%. Here I was at 80% probably going backwards to 50. I was like whoa what happened and so then I just kind of got in the straight and narrow and just said okay I gotta really make sure I kind of make sure I kind of keep it easy until I get back to 100% because, you know, um, it just you didn’t realize how much, uh, things could go backwards so fast so you really gotta wait till you get a 100% on things and so overall I mean the only thing lingering for me right now is a slight bit of um out of breathiness and, uh, this little lingering deep tickle cough like right now you can feel it like someone’s tickling the back of your throat with your finger and you want to cough to scratch it, kind of like that and so that’s where I’m at now. That’s like kind of makes it feel like I scratch it right there, right. So, I’m doing some ginger tea, I’m doing with the Manuka honey that soothes it like that helps with the irritation. It’s not knocking the cough down. Doing some, Elderberry, um, doing some thieves, uh, natural cough drops with essential oils, um, also doing some nebulizer so I’m doing some glutathione nebulization so those are couple of things I’m doing and then obviously sinus flushes, the amount of mucus that is coming out of me is out of control so sinus flushes are really, really important because if you do not flush your sinuses, the amount of stuff that stays inside of you, oh my God. So, flushing my sinuses out 3-4 times a day, you know, really good saline reverse osmosis with a little bit of silver in there to kind of keep things flushed out is helping a lot. So, that’s kind of where I’m at but honestly feeling pretty good, um, the whole family got it purposefully, my wife had it and I’m like come over here honey gave her a big kiss and then I kissed all my kids, I’m like we’re done. We’re gonna get this thing all together, be done with it all that way we’re not, you know, I get it next month and then I’m isolating for two weeks and then my kids get no we’re gonna get it all at the same time and surprisingly my kids’ symptoms were 80% less than the adults, super, super minor.  I couldn’t believe how minor it was for the kids, so very interesting. So, that was kind of my experience with, uh, with the big C, uh, so to speak. And also, the big correlation I was listening to someone talk about this, the, a lot of the post C symptoms that we see after, right, people that have dysglycemia, and blood sugar issues tend to be a big driving factor of a lot of these post viral symptoms afterwards. Talking about post-viral fatigue, one of the big things is make sure you manage your glycemia, meaning you’re having good protein, you’re having good fats, you’re not eating a bunch of refined sugar, grains, those kinds of things. Make sure you put good metaphorical logs on the fire, good proteins, good fats to really work on blood sugar stability. 

Evan Brand: Yeah. Yeah. We’ll I’m glad that you’re coming through it. Regarding the shortness of breath, I would kind of put that in the same category as the post viral fatigue because that shortness of breath can create fatigue and the best thing that’s helped me and has helped many clients is doing the color oxygen. So, ChlorOxygen, you can get that on amazon, it’s readily available. And it’s just a, it’s a liquid chlorophyll extract. So, when you do that within probably 5-10 minutes, you can feel a difference, so it’s like C-h-l-o-r-Oxygen, ChlorOxygen. I would probably do 10-20 drops up to 3 times per day. That thing is absolutely incredible. You can go as high as one tablespoon in 20 ounces of water and just sip on that throughout the day. I had one guy in New York, major, major issues with shortness of breath in the acute and the long term and that ChlorOxygen literally just turned his situation around. So, I’d get some of that stuff. 

Dr. Justin Marchegiani: So, it’s C-h-l-o-r Oxygen?

Evan Brand: Yeah, ChlorOxygen. Yeah, and it comes in a little bottle tincture and it’s incredible. Also, something I’ve used personally, I’ve used with several clients too is Ailanthus. Ailanthus is three of heaven which is an invasive tree. I see a lot of it in Kentucky but you can buy Ailanthus tincture and that one is also really, really good. 

Dr. Justin Marchegiani: Interesting. Is this the one, right here, Is the ChlorOxygen? 

Evan Brand: Yeah. That’s the one. Yep. 

Dr. Justin Marchegiani: Okay. Cool.

Evan Brand: Get you some of that but should help because that’s the problem is, you know, the shortness of breath was pretty bad for me and I felt better, you know, I got infected a long time ago. It was like August 2020 and then six months later that’s when I started to have some shortness of breath which I was like, holy crap and so luckily, I was able to knock it out, uh, with Demectin and uh, yeah, Demectin really helped me and then the nebulizer and the ChlorOxygen, I would say that combination was an absolute game changer, luckily, I haven’t had any issues since then. But what we are seeing is that the mitochondria have a role in this and some of this post-viral fatigue we’re seeing is due to mitochondrial damage so I’ve been fortunate enough to see a few dozen people now. And in terms of organic acids testing after the virus, and we are seeing that the mitochondria definitely showed dysfunction. You and I talked about this many times on other podcast about the mitochondria. We can measure the dysfunction and so what we’re doing is we’re coming in with mitochondrial support nutrients so CoQ10, we’re coming in with carnitine, ribose, a lot of these amino acids and B vitamins like riboflavin which can help fuel the krebs cycle and then also we can use things like PQQ to help get the mitochondrial biogenesis going, meaning we’re literally making new mitochondria so we can measure this on paper. So, if you guys are suffering, you know, one of us can reach out or you reach out to us rather and then we can get the urine looked at because we can measure this. You don’t have to guess where is this fatigue coming from. If it’s a mitochondrial induced problem, we can measure that. Now, you have permission to have multiple things wrong with you so there could be a dopamine problem, there could be a mitochondrial problem, there could be toxin problem. So, rarely is there one issue causing this fatigue but the goal is for us to try to get as many puzzle pieces laid out in front of us and then make an appropriate protocol.    

Dr. Justin Marchegiani: 100%. I’d say, the worst thing about COVID for me right now, coffee tastes bitter like it tastes bitter, almost a little bit sour, does not taste like coffee. I’ve almost been like I’m not even gonna drink it right now until this thing gets better because it does not taste that good but for me I’m just alright, I got, you know, 20 grams of collagen in there, I got some good fats, I kind of look at it as like a meal replacement for me. So, that’s probably the worst thing the whole time. For me, it kind of felt like a cold. I’d say a mild, mild to middle of the road cold. The only thing that really surprised me was that, that back swing where I was like 80% better and then went backwards that was the hardest thing. 

Evan Brand: And, it could have been you overdoing it for sure, I mean, 

Dr. Justin Marchegiani: oh, you totally did. 

Evan Brand: Yeah. I mean I did have a little bit of that too where I kind of felt like I was better, overdid it and then I heard it again, so. 

Dr. Justin Marchegiani: Yeah. 100%. So, excuse me, anything else you wanted to highlight on that so far? I would say post-viral stuff, the things that I’m doing right now and I recommend people do, in general, are gonna be Adaptogens and I like medicinal mushrooms. So, Shiitake, Maitake, Reishi. Reishi is great. I love it because it does deactivate viruses. It does build up and support the natural killer immune cells so I do like that, uh, any type of ginseng, Ashwagandha, these are things that help support energy production, support the adrenals, help buffer the HPA excess. So, any of these types of things are gonna be, uh, helpful too.  

Evan Brand: You need to get on some Lion’s Mane too for your taste because what I’m finding is that the nerves are damaged and that’s affecting the sinus. So, the sense of smell, sense of taste, some of that is related to nerve damage. So, I would probably hit Lion’s Mane, maybe like two caps twice a day. That’s been helpful to restore the sense of smell and taste in some people. 

Dr. Justin Marchegiani: It’s probably not damaged. It’s probably just more inflammation, right? 

Evan Brand: Well, the long-term stuff, I’m talking to people just long-term. I’m talking to people that you know 6-8 months later say, I still can’t taste or smell. Bringing in Lion’s Mane, like 2 caps twice a day. It takes a few months but you know it does increase nerve growth factor and so I think that’s the mechanism. 

Dr. Justin Marchegiani: That’s interesting. Yeah. I do have some Lion’s Mane. I’ll definitely add that in. I mean, I think medicinal mushrooms are gonna be really good to, um, be on top of, uh, just supporting your immune system and like helping with, um, the body regenerate and heal better. 

Evan Brand: Yeah. Gabe was asking a question in the live chat on YouTube. How did you guys catch it? I don’t know, I mean I work from home. You know, I’ve got a home office, uh, Justin has a home office as well, you know, I do go out, uh. 

Dr. Justin Marchegiani: Personally, it’s the new variant. The new variant has an R-naught of seven, which is that’s equal to, uh, measles so the delta variant had an R-naught of 2 or 3 so that means for every one person that gets it, it can be passed to 2-3 on average, right. The new omicron variant, it’s seven, so you can literally pass it to seven people so I think my wife was in a yoga class with three people and they were like spread out across that broom like they were like way you know spaced apart, you know, for just all the safety reasons and it was still able to get it so my whole take on omicron, it’s very, um, I think the symptoms are milder than delta for sure. That’s what everything’s been reported but, um, it’s way more contagious. Everyone’s gonna get it at this point, you just gotta have your plan and, um, be ready ahead of time, right? People don’t have a plan and then when they get it then they get stuck and they feel like they have to go to the hospital and you don’t have as many options there so try to have a, um, outpatient plan ready to rock and roll but yeah, you’re gonna get it because the, um, our knot on this thing, right, is that seven which is at a level close to measles so it’s right there. So, if you haven’t got it yet, you will. Anything else you wanna highlight on the immune side, on the post-viral stuff obviously I’m a big fan of ginger, I think ginger is nice because it’s anti-inflammatory, anti-viral, uh, helps with lymphatic. So, if your kind of like have a lot of like stagnant lymph in the chest area or in the neck I really keeps the lymph moving all that’s very helpful. 

Evan Brand: Yeah. There was, uh, one person that commented if you’ve had delta you should have some memory T cells that will help if you get infected. Yes supposedly. Supposedly, um.

Dr. Justin Marchegiani: Yeah. You definitely should have memory T cells as well as memory B cells, right? So, even if you were to get sick again, um, you’re gonna be able to recruit antibodies way faster, right? Normally when you get sick if you’re first time getting exposed to an infection it takes about a week or so to really get those antibodies ramped up and so even if you were to get sick twice, you’re gonna be able to make those antibodies inside of, you know, 24 hours or so. So, you’re gonna be able to bring those antibodies to the table a lot faster and so that’s, um, that’s pretty cool. That’s pretty helpful. 

Evan Brand: Yeah. Other strategies, uh, post-viral fatigue hyperbaric oxygen has been helpful. I’ve seen several clients that luckily have lived in a city where they’ve had access to do hyperbaric oxygen. Essentially, what it is, is it’s replicating being under water under water about 10 to 12 feet so that pressure is helping to get oxygen deeper inside of you. So, some of these tissues may have been starved of oxygen. This sort of mild hypoxia or hypoxemia, you know, you can basically reverse that by getting the hyperbaric oxygen. There are some people that can do there’s oxygen cans, little portable oxygen shots, if you will but it’s nothing compared to an oxygen concentrator with the hyperbaric oxygen so that’s good ongoing, I mean, I’ve had clients with Lyme that have done hyperbaric we know that’s incredible for traumatic brain injuries and concussions and that sort of thing. So, even if this is just a long-term fatigue problem, not related to viral issues at all, you know, hyperbaric is another good tool, you’re looking at probably around 100 a session but, you know, what, what’s your health? What is your health worth? So. 

Dr. Justin Marchegiani: Exactly. One thing I did was very helpful was use my infrared sauna the last couple of days. That was helpful, just getting a really good sweat in felt very good, you know, raising that body temperature up can be very helpful just at um at your body knocking down viruses. That’s part of the reason why you get, um, chill while you get the nutshells but, uh, why you get a fever right. It’s part of the reason your immune system is actually knocking down some of that bacteria and or viruses by doing it that way so using an infrared sauna can be helpful too. 

Evan Brand: So, look at your mitochondria, get your organic acids test done, we can measure that and look at mitochondrial function come in with specific support whether it’s B vitamins, adaptogenic herbs like Rhodiola, you mentioned, Siberian ginseng or Eleuthero. There’s medicinal mushrooms like cordyceps which there is some benefits. There are some papers on cordyceps and athletes and improving blood flow. There may be some level of oxygenation that happens with cordyceps too. So, cordyceps, reishi mushroom, I think the Lion’s mane for the brain and for the nerves would be beneficial, the ChlorOxygen for any of the shortness of breath along with the fatigue, rest, I mean just getting good quality sleep, making sure you got to do whatever you can to get good quality sleep. So, all the same sleep hygiene habits we’ve talked about for a decade together apply in regards to candling down at night if you need some passion flower. Even melatonin, there’s some really cool studies on melatonin. We know, it’s a very powerful antioxidant and we are seeing higher doses of melatonin be beneficial. So, in general, somewhere around 5 milligrams but there are some papers going wat up 30 – 40 – 50 milligrams and beyond. I don’t know a ton about the high dose so I’ll just tell you that the regular dose standard dosing is better than nothing. 

Dr. Justin Marchegiani: It was that melatonin?

Evan Brand: Melatonin. Yes. 

Dr. Justin Marchegiani: Yeah. Usually, it’s like the higher dose is like 10 milligrams and that’s gonna help with the oxygenation and then 30 – 500 milligrams for the arginine that’s to really increase the oxygenation. 

Evan Brand: Yeah. The arginine for like nitric oxide production. Beet powder, you know, beet powder would be good too. So, anything you could do to create some vasodilation is gonna be smart. 

Dr. Justin Marchegiani: Very cool. Anything else you wanna add, Evan?

Evan Brand: I think that’s it. If you need help, reach out, get tested, hopefully you get back on the full mend here so, keep, keep rolling. You’re doing a great job and hope everybody is doing well and we’ll be in touch next week. If you need help clinically, please reach out. You can reach out to Dr. J at or me, Evan Brand, at We’re happy to help you guys. Keep your head up. keep moving forward.   

Dr. Justin Marchegiani: I think the big thing out of the gates is to make sure you have time to sleep, rest. Don’t overdo it. Just know your body still needs more time even when you, when you’ve gotten through the whole thing to recover. Don’t overdo it. That’s really important. Keep the foundational nutrients dialed in so that would be like zinc, vitamin C, vitamin D, you know, you can keep those things in there. You may not have to use them at such a high level that you did with the infection but keep some of those nutrients. Don’t go from something to nothing. Keep something in there the whole time, find a medicinal mushroom that you like, find an adaptogen that you like. Maybe keep a little bit of ginger tea going. Something that has some antiviral support and um, you know, try to get a little bit of movement but if it’s making you feel winded then just try to do just enough where you can feel like you’re doing something but not where it’s overly taxing you. I think it’s really important to kind of meet that right in the middle. 

Evan Brand: Last thing, two last things, a low histamine diet is generally pretty helpful because there are a lot of issues with mast cell activation being triggered from this. So, a lower histamine diet, fresh meat, and no leftovers is very important. And then, histamine support. I’ve got a product called histamine support but essentially it’s quercetin plus some other nutrients so anything, you can do to stabilize your mast cells that’s gonna be helpful because muscle activation can cause fatigue, meaning, after the viral issue was over, the immune system can sort of have PTSD for lack of a better terminology and the immune system will go into this crazy state where it will shut you down so that fatigue trying to rebuild that energy back up is re-regulating the immune system so like the quercetin, other mast cell stabilizers are very helpful. 

Dr. Justin Marchegiani: Love it. Love it. Love it. Makes total sense and again not everyone’s gonna have that issue but you know, it’s kind of good to know if you fit into that camp. Those are a couple of strategies out of the gates. Anything else, Evan?

Evan Brand: No, that’s it. Take it easy. If people need help, reach out and will be available. 

Dr. Justin Marchegiani: Yeah. We’re here to help you guys. I’ll probably be back later on today here. So, keep a lookout, comments down below. Let us know your thoughts on the topic, we appreciate a review. We appreciate shares to friends and family. Really helps us get the word out. You guys have a phenomenal day. We’ll talk soon. 

Evan Brand: Take it easy. Bye-bye

Dr. Justin Marchegiani: Bye you all. 


Recovering From The Holidays | Podcast #362

The holiday season is meant to be a joyous occasion that brings family and friends together. But even amid all the excitement, there are often moments of stress and anxiety. If you are recovering from health issues, this broad spectrum of holiday emotions can challenge even your best intentions for recovery.

Dr. J and Evan Brand talk about these issues and handle them. Though the risk of relapse runs high during the holidays, it is not inevitable. If you are in recovery from any health issues, you can take steps to stay healthy and safe. Becoming aware of potentially triggering situations and knowing how to prepare for them can help minimize your risk of relapse and allow you to enjoy your holiday season truly.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

0:00 – Introduction;
3:15 – The link of EMF to overall health
8:43 – Helpful enzymes, foods, and tests for health recovery

Dr. Justin Marchegiani: It’s Dr. J here in the house with Evan Brand, our post-holiday show. Today’s gonna be just a quick podcast on how to recover from holidays, uh, case you don’t know, my whole family has COVID right now, so we are dealing with that and doing all kinds of natural immune support, all the things that I talked about with my patients and talk about on the past to help improve and boost your immune system, so overall feeling actually pretty good, feeling pretty good, my family’s actually doing pretty descent so we are plowing through it, feeling great. Evan, how you doing man? How are the holidays for you?

Evan Brand: Doing really well and yeah like I told you before we hit record, sorry to hear that but also, it’s good to get it over with. We know that natural immunity is the best immunity far better than any other immunity that other people might like to convince you and that it is free and the best and most robust immunity. So, it’s amazing because paying attention to the media, you would think that you should be like laying out right now but here you are standing up at your standing desk, you’re doing your normal thing and you’re here on a podcast so I love to just blow through the narrative of the and blast through the fear. So, beyond that we’re doing great over here man, we’re ready to dive into the holiday talk and this time of year is where you get like 50-50. Like half the people are like, okay I’m gonna go haywire, I’m gonna eat whatever the hell I want and I don’t care and then the other people like, no way I gotta get dialed in, new year’s coming and for some reason January 1st is this symbolic day where people feel like they want to get stuff together. I encourage you to do it now, don’t wait until January to try to get yourself better and so this idea of like cheat days or the holidays are here so I’m gonna go off the rails, I personally don’t do that at all. I stay completely dialed in just because I know it’s gonna affect my brain it’s gonna affect my gut, I don’t wanna have that bad poop, I don’t wanna have bad sleep, I don’t wanna have skin outbreaks, so for me, personally, I do the same thing I always do. If I want like good treat and I want to feel like I’m getting something good, I might go for like a Siete cookie and it’s like maybe one gram of sugar per cookie max but I’m not just gonna go eat a bunch of gluten and rolls and dairy and all that just because it’s the holiday so I personally think like this idea of like a cheat day or a cheat weekend, I just think, it’s crap because you and I’ve talked about this before but like gluten antibodies, they can go up for months after eating gluten so for me, I’m not just gonna go do that and set off the immune system for potentially that long.  

Dr. Justin Marchegiani: You know, I totally agree. So, what we kind of did is we had, um, squash pie from a true food kitchen, we bought one or two of those and we used that as kind of our dessert so it’s kind of a gluten-free, grain-free dessert option. So, we had that true food kitchen’s great. Their desserts are amazing. We also had some bacon-wrapped dates which were awesome, I mean you get the sweets and savory there and then we also got some poblano peppers, we put some cream cheese in it, again, cream cheese is a little bit better than regular cheese, a little more lactose casein, um, lowering that at least but a little bit of dairy and we wrap bacon around that. So, those were kind of our two [2:49] I got the grill fired up. Got some atria buys just cut them really, really thin. Put some toothpicks in them and just had a lot of finger food like that and that was nice, really simple, really easy, um, so we try to, you know, try to mitigate a lot of the destruction by choosing healthier, less inflammatory options but also things that allow us to feel pretty satiated and pretty full and not have these blood sugar swings that people get when they don’t have enough protein or fat with their meal either.    

Evan Brand: Yeah. If you want a crazy book, we had a question coming on the live chat about detoxing from EMF coming back to work with headaches and this does pertain to the holidays too. I’ve been reading this over the past weekend. It’s a book called, “The invisible rainbow”, it’ll blow your mind so if you want to read that book it’s all the scientific studies organized into one place about EMF exposure and how we’ve known since the 1800s when the telegram and the telegram wires first came out, people were having reactions to electromagnetic fields and this certainly does affect you. So, all the people just got new, uh, apple air pods, and apple watches and all these, uh, cell towers that they keep on their wrists and in their pocket, you know, I think it is smart to try to mitigate some of that going into the new year. There’s some studies in that book too about EMF and blood sugar and how even people that were dialed in with their diet had elevations and fasting glucose simply by being exposed to radio frequencies so all you with your new tech toys that you got over the holidays, I would encourage you, I think seeing is believing, not everyone is sensitive, meaning they’re not going to feel it but at a biological level there probably is something going on so you could get an rf meter, there’s one out of Canada called Safe and Sound, that’s what I used and I’ve measured, I stood face to face with the cell phone tower and that was about 10,000 microwatts per  square meter, an apple watch that a friend of ours had was 2 million microwatts per square meter so people freak out about cell towers but they’ve got. I can’t even do the math, a 100x the radiation of a cell tower on their wrist all day so on the EMF subject, I would not use or recommend those devices.  

Dr. Justin Marchegiani: Yeah, what I do is I have a little tripod here. I take my phone and I put it on a tripod and I put it in front of me and I’ll just use siri to kind of call my patients like that so I’ll put it away from me which is nice. That way it’s not on my person and then I use, um, just little holster like this and I tuck my phone in like this and a couple of things you can do so you can actually, I don’t do this personally but you can slit the side here and you can put some aluminum foil in and that will create a protective barrier with the phone going into your skin so that’s an option if you’re really sensitive. I put it on my back right hip so there’s a lot of tissue there. There’s a lot of bone, a lot of meat, a lot of glute muscle, um, and the cell phone. It really is exponential, it has a logarithmic intensity so the first inch is the most intense and that it logarithmically drops off. Now, if you put the, your phone in your front pocket and it’s right over your ovaries or uh, genitals, that’s a problem, right? Because that’s gonna negatively, now your like inside a couple of inches of that tissue and it’s more sensitive tissue and you don’t have a lot of meat i.e., thick muscle like the glute or a lot of bone in the way, right, that tissue’s kind of much more dense and so ideally, you know, if you’re a female, keep it in your back pocket, don’t put it over tissue like that. That’s bad. Don’t put it in your front pocket female or male, keep it in your back pocket or get a holster like I do, put it right in the back part of your hip and if you’re more sensitive just a little slit in and put some aluminum foil right up against it and that’ll give a protective barrier. 

Evan Brand: Yeah. A lot of times, they sell like silver fabric too, like, I got, I’ve got a shirt that’s like a silver lined shirt, I’ve tested it. it literally, I mean I had a cell phone right in front of me, it was like a million microwatts per square meter, throw in the meter just haywire and I put the shirt on put the meter inside my shirt and it was nothing it was in the green so a lot of these are lined with silver. These fabrics that are really cool so I have had some sensitive clients in the UK who, we’ve got them some of that EMF protective clothing and it has been helpful like you said distance is your friend so getting away from that is key and then I do all my calls just on my computer so I use google voice or I’ll use skype and so I’m just on a hardware connection so I’m using, I’m making zero, uh, radioactive calls during the day or like you and I know we do a lot of zoom calls with our clients too, so zoom, facetime those are good options if you guys are having to do a lot of calls for work and mitigate your risk, you can do facetime on the computer which is what I do and it’s a zero RF way of talking to people and then were hardwired, I’m hardware, I know you go, like wireless headset but I go hardwired on everything.  

Dr. Justin Marchegiani: Yep. And I use this headset right here so then the signal, the receiver’s here versus so there’s about an inch or so of tissue, uh, you know, fabric here because the phone really is the first inch is the most and where it’s really concerning is when you have those I, uh, with the little pods in the ear, they go right deep in the ear and everything the receiver is right in there and so there’s not a lot of tissue between you and your external auditory meatus and going into your brain. Something like this where it’s denser and it’s actually more outside or I use these on purpose because it’s the signal is in here and it’s farther away from the head. But in general, um, Bluetooth is pretty weak though, in general, like, Bluetooth only can travel like 30 or 40 feet so I’m not really worried about that. I’m not worried about the 5g signals that are traveling miles upon miles upon miles. A 30-foot signal isn’t as big of a deal as one that can go miles and miles so, I think, if you can plug in, that’s great or use a speakerphone or you have the talk on your phone at least an inch or two away because even apple in their handbook when I understand fact, check me or not, it says you wanna hold your phone at least an inch away from their head, your head. So, that’s really important. 

Evan Brand: I think there was something in the fine print about that about the emissions that come from it. Yeah. On the topic of more, you know, back of back, back to like diet and food exposure and that kind of thing I know you and I both sell professional enzymes that we use clinically with people so I think that’d be a good strategy if you do feel like for some reason, you’re off the rails or maybe you’re not dialed back in yet. I do recommend, like, a broad-spectrum enzyme. Just because you can start to break down dairy and gluten molecules using enzymes so I’m not telling you to eat those things but people got to live and people are not always gonna be dialed in. So, I think a good broad-spectrum enzyme would be a smart thing to do and then first thing of the year that I know you would recommend as well as me is I would get some labs done, I would look at your stool, I would look at your urine and start your year with some data so that you’re not coming into the year blindly. You’re coming into the year with some information about your mitochondria, how they are performing. What do your neurotransmitters look like? How’s your dopamine and serotonin levels? What about your nutrients? How’s your vitamin C? How’s your B vitamins? What’s your glutathione status? Do you have bacterial overgrowth? Do you have Candida? Do you have parasites? Do you have gut inflammation? Do you have gluten antibodies? And your immune system is pissed off right now, I think it’d be a great strategy to start off the year with getting data. So, if you need help clinically, you can reach out to us, we can run these labs on you, we send them to your home, you do an at-home stool and at-home urine, we’ve done this literally thousands of times, you can get over a hundred pieces of data just with one stool and one urine sample so I’d highly recommend that, I think that’s the best thing you can do. I think, it’s great to get all the foundational pieces in order but when you really want to tease things apart and figure out what you’re up against, you’ve got a test not guess and so if you go buy some random energy supplement or some random fat burning supplement or some random, you know pre-workout formula, you don’t really know what you’re doing. 

Dr. Justin Marchegiani: 100%. So, just kind of foundational things out of the gate, you’re through the holidays, try to mitigate the damage by choosing foods that are gonna be less inflammatory still give you the feeling of your enjoying life right, you’re cheating a little bit but it’s mitigating the damage like Evan said, higher quality broad-spectrum enzymes and acids especially when you’re eating those food. There’s a lot of foods that you’re more intolerant to. You have a hard time breaking it down and the lack of breakdown of that food can create more bloating and gas and constipation. So, we’ll put our recommended digestive supports below in the links below so you can see them. We have different HCl, enzymes and bile support products and then we have different binders or detoxification support with glutathione or sulfur or aminos, down below. Also, the immune support I’m using right now, just to give you kind of top five things I’m taking right now, of course vitamin D, of course an acetylcysteine, really important, um, vitamin C, quercetin, and I would say reishi mushroom is an excellent thing, these are all things that I’m doing right now, of course, a couple other things that I’m doing, uh, preventively are going to be sinus flushes where I rotate between either a sinus flush with saline between iodine, silver and hydrogen peroxide, all diluted and I’ve been doing a little bit of nebulizing hydrogen peroxide. Now, I’ve been just taking the 5mL saline blister packs and doing about 3 to 4 drops of hydrogen peroxide in there which brings the amount to about point one percent and that works really good just trying to keep, um, kind of disinfecting that upper respiratory tract airway. That’s where the virus tends to replicate and grow and if we can knock that down with flushing or nebulizing that prevents the viral load from going up which that’s what creates all the inflammation right so if you keep the viral load down, keep some good natural anti-inflammatory going, keep your immune system supported of course, sugar suppresses your immune system get 12 hours of sleep at night all these are foundational things out of the gates. 

Evan Brand: Yeah. And your lungs believe it or not make hydrogen peroxide so when people, there’s you know, the internet supposed fact checkers which in the court of law now Facebook admitted that their fact checkers are simply opinions and they’re not truly fact checkers so that’s important for people to know but there’s been some stuff online about hydrogen peroxide telling people this is dangerous and all that. We make hydrogen peroxide in our bodies, so you’re taking it at a diluted rate. I took it straight, I did this straight three percent to see how it was, it burned a little bit in my nose but other than that it was fine, I did a whole podcast with doctor Thomas Levy on this. He’s a cardiologist, who’s been speaking, I think, he did, uh, a talk with Dr. Pergola about the topic so if you wanna listen to it, it’s Thomas Levy, we talked all about the hydrogen peroxide nebulization and the IV vitamin C which he’s using for the rouleaux formation from people that are getting the injection, uh, he’s using IV vitamin C to help break up the blood so really, really cool resource. Thomas Levy, he’s a genius. 

Dr. Justin Marchegiani: Very cool. Yeah. So, you want to bring it down to about point one percent so it’s more gentle. If you go a little too much, you know, it’ll just give you a little burning and such and make sure it’s saline that you’re using. I use blister pack saline. I’ll put the link down for that as well. You want one that’s specific for a nebulizer just so you don’t irritate your respiratory tract. You wanna make sure it’s good, clean, and sterile saline with just the right amount of minerals to be in harmony with that, um, mucosal tissue. Well, anything else here, Evan, you wanna highlight? We’ll keep it really quick today. 

Evan Brand: I’m happy you’re doing good and you’re doing all the right thing so definitely all the things that should be headline news, the things that are very safe and effective and as Dr. Levy made the point to me, you’re talking pennies or less than pennies per dose and some of the supplements and nutrients that you’re taking so just in regards to cost this is almost free, the protocol you are using, this is very safe at-home early treatment protocol so I’m just really proud you’re doing that and spreading the word and hopefully we can help more people. 

Dr. Justin Marchegiani: Absolutely, Evan. Really appreciate it and guys listening if you wanna get your 2022 off the right start and you have some health issues you wanna dive into feel free to head over to to reach out to Evan or myself, Dr. J in, we are here to support your natural health kind of root health needs. We’re here for you, we’ll put our recommended products and things that we chatted about in the description notes below and if you guys enjoyed, shared with your friends and family and write us a review, we’ll all the links down below, you guys have a phenomenal holiday season and I hope your Christmas and holidays are great.

Evan Brand: Yep. We’ll see you all soon. Take it easy, stay strong, keep your head up, and stay motivated. Don’t give in to fear, everything’s gonna be okay.

Dr. Justin Marchegiani: Take care you all. Bye now. 

Evan Brand: See ya. 


The Nuts and Bolts of Your Mitochondria – How to Enhance Mitochondrial Function | Podcast #349

Have you ever thought about what powers are inside your body? In this video, Dr. J and Evan talk about mitochondria and how to boost them.

When we talk about your body’s powers, the easy answer is nutrients, of course! Our body transforms those nutrients into energy, and it’s that energy that boosts the cells in our body. All types of cells have small generators called mitochondria that, in many ways, are their sources for life. Mitochondria are the only part of the cell where our basic life requirements — food and air — are combined to make energy in a process known as the Krebs cycle.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

0:00:      Introduction
1:30:      The role of creatine in mitochondria
6:34:      Energy pathways
14:47:    Cell Danger Response
16:07:    Citric Acid Cycle

Dr. Justin Marchegiani: Mitochondrial function, your mitochondria, little the powerhouses in your cell and they help generate ATP which is the cellular currency of energy so to speak. And we’re going to talk about natural ways to improve mitochondrial function, Evan, and how we doing today, man.

Evan Brand: Doing really well. I think first, let’s dive into some of the big assaults that we have as a modern society on mitochondria. And that could be anything from viruses, bacteria, parasites, gut infections, pesticides, herbicides, heavy metals, plastics, phthalate’s, the BPA, the BPS, flame retardants, nonstick chemicals, car exhaust, air pollution. That I miss any I mean.

Dr. Justin Marchegiani:  Like you hit a lot of I would say being sedentary. There’s a lot of mitochondria in your muscles. And if you don’t do enough, you’ll put enough force to those muscles, they will atrophy. And so just not doing enough about creating enough stimulus on your body. That could definitely we can and decrease your mitochondria in your muscles. So, I would say, sedentary and in active resistance through your muscles.

Evan Brand: OK, OK that’s a good point.  That’s a good point. So, you’re saying that, like, just in general, you have to have some level of physical stimulation physical activity to keep the mitochondria working. I guess it’s kind of like an old car that you’ve sat there…

Dr. Justin Marchegiani: All your muscles at least. Yeah, ’cause if you decrease, you know your muscle levels via just atrophy due to lack of use. Yeah, your muscles will shrink absolutely and that’s your mitochondria will shrink for.

Evan Brand:  Sure, what about creatine? Do you know anything about the role of creatine in mitochondria? ’cause I know when I’m taking creatine, I just I feel stronger? Obviously, there’s creatine’s used a lot in like bodybuilding world, but there’s gotta be a mitochondrial mechanism there because I’ll tell you I feel like. I can lift, you know, at least a good 1020 pounds heavier on particular exercises with creatine in my system.

Dr. Justin Marchegiani:  Yeah, me crazy definitely has an effect on growth hormone and improving growth hormone stuff that will help with muscle. Creatine is like instant energy for the muscle. So, it’s it’s there. It’s ready to be used right away in that first 10 seconds or five, five to 10 seconds of muscle use or like explosion movement through that muscle. So, that definitely plays a role in muscle. I’m not sure how it plugs in 100%. I see ’cause really you know with ATP right in the mitochondrial function? If you look inside the mitochondria you have glycolysis and then you have the electron transport chain. Or I’m sorry, you have the Krebs cycle citric acid cycle and that plugs into the electron transport chain. So, glycolysis that’s going to be utilizing the carbohydrate in the muscle right glycogen in the muscle. Fast immediate source. I think creating plugs into that top part. And then you have the Krebs cycle citric acid cycle, where B vitamins, magnesium. All these different things kind of plug into that and with that. With the citric acid or Kreb cycle, that didn’t mean the same thing. Essentially, they’re grabbing hydrogens, right? So, there it’s it’s a reducing agent, so it’s just grabbing reproduce. Reduction is a gain in electrons and so you have NAD goes around. Then it grabs NADH so you get 3 NADH and I think 1FADH2 so you have FADH. And it grabs another hydrogen and that becomes FADH2, and so it’s grabbing all these hydrogens. And then it’s essentially bringing those hydrogens downstream into the electron transport. Jane and Beta fatty acid oxidation there and so yeah, I think you generate was at 36 to 39 ATP through the Krebs cycle and the electron transport chain.

Evan Brand: Unless you’re in like chronic fatigue stayed, this cell danger response, and I think you’re spitting out something low like 2 maybe 3 ATP. I’ve read about this cell danger response. They just call it HDR in the literature, but it talks about how. The cell danger response, could be initiated by trauma or a car wreck or even mold exposure or tick-borne illnesses, or viruses. There’s a lot of you know, Epstein Barr. You’ll see the link between like mono and chronic fatigue. It said that these people are in this state of just a low power output, or even if you have the nutrients, you’re just not generating the ATP with some I don’t know if it was Caitlyn or somebody that you and I had looked into where there was a talk on this about. How the w the the ATP was literally in the single digits. The low single-digit output in some of these states. So, the message here is that for people that have chronic fatigue, you got to realize there is a mitochondrial component to this. Why don’t we talk about testing a little bit? The main thing that you and I are going to look at is going to be the organic acids. I know there are some other tests out there. I’ll admit I’ve had clients send them to me such as the mito swab. I’ve not run the model swab. Personally, I don’t know enough about it to speak on it much, but I’ll just say that it does exist. I believe it is a a mouth swab and it’s probably looking at just a couple generic markers in the saliva. But we like to use the organic acids test because, as you mentioned, there’s the Krebs cycle metabolites on there. We can look into the supinate or what some people call succinic acid. You’ve got the malic acid. You’ve got fumarate. There are other markers on there, and we we see when people have talks and exposure. Like I said in the beginning, the heavy metals, the mold, the pesticides will see those. Mitochondrial markers go up. And the higher the numbers go, generally, the more tired someone is because that indicates more damage to that Krebs cycle. So, the oh is huge, and then obviously we’ll look at stool too. Now the stool test you don’t measure like the stool tests we’re running. You’re not measuring mitochondrial function, but I look at it in a roundabout way. Meaning if you have all these gut infections producing toxins that could be damaging mitochondria as well, so we know that when we clear the gut out, we see the mitochondrial function improve.

Dr. Justin Marchegiani: 100%. Yep 110%. I want to just put something on screens. People can see it here I guess is really helpful.

Evan Brand: Have you seen or heard about that my to swab before? Have you seen anybody send you those?

Dr. Justin Marchegiani: I have, I’ve ran up. Fulham, it’s kind of a binary test. It gives you a result my the issue I have it’s not a lot of actionable information. It’s like OK, you know there’s some issues there, but then now what’s, what’s the remedy that you’re going to plug in from a diet lifestyle supplement? Toxin reduction execution right? What’s the next step on it? So that’s the problem with some. Of those tests, I always. Look and I always ask well what’s the corrective action based on the test showing uses a concern.

Evan Brand: Yeah, yeah

Dr. Justin Marchegiani: That makes sense.

Evan Brand: That’s the problem with a lot of them like I’ve seen a lot of these stool testing companies. Same thing there’s like so much data. Well, this percent of this bacteria and this percent of that. It’s like, what do I do with that? Is that an infection? Is that not an infection? So you and I’ve seen the same problem in other categories of health tests do.

Dr. Justin Marchegiani: 100%. I want to show a couple things on screen here? Just so it’s crystal. Where the mitochondria is and how all these different energy pathways plug in, I think it’s important I’m going to pull it up here on screen in just a second so people can see it.

Evan Brand: Yeah, people listening on audio, they’re going to be lost. So just look up Doctor Justin YouTube page and you’ll be able to view some of this stuff. Some stuff, like mitochondria, gets a bit geeky. The the main thing here is toxins are a big factor in damaging this cycle and you gotta get toxins out. Reduce exposure where you can and we can run actually chemical test on your current too so we could talk about that in a minute.


Dr. Justin Marchegiani: Absolutely, and so if you look here right. Do you have the mitochondria right here. Some middle part, the mitochondri. The outer part is the cytosol.  So, from what I understand, like creatine is going to plug more into the cytosol and glycolysis, OK, but then you’re going to see you get about two ATP which is adenosine triphosphate. And this gets broken down into ADP and you get energy right? And so, you have glycolysis which generates a little bit of ATP 2. And creatine to plug more on the outside then that goes into your mitochondria. Now you have the Krebs cycle and the electron transport chain electron transport chains part of also the beta fatty acid oxidation. That’s how you burn fat for fuel. OK, so Krebs cycle that churns around twice, and essentially what you’re doing is you’re gathering NAD and FADH2. NAD&FADH are grabbing hydrogen so and a design to grab a hydrogen making NAD. HFADH is going to grab a hydrogen, making FADH2, so I think you’re going to grab it’s like two or three. NADH is, and then one FADH2. And all those hydrogens then go into the electron transport chain here and this is where you generate most of your ATP. And again, what comes out, oxygen comes and this is why, if you’re like anemic right? And you’re not carrying oxygen. Well, that’s why you’re going to get tired and this is going to have an effect on your thyroid and your adrenals because the mitochondria is important for energy at all levels. And so if we have anemic issues or were inflamed because inflammation is going to make it harder to carry oxygen all. And also nutrition, because this electron transport chain, when we run the organic acid test, we can look at citrate, malate, fumarate, succinate. These are important metabolic essentially inputs into the Krebs cycle that correlate with certain nutrients like amino acids, alpha-lipoic acid, magnesium B vitamins, and so we can get a window on how this. Krebs Cycle was functioning based on the organic acid testing at some of those compounds and then all sister connotate citrate, right? These are really important, and then electron transport chain we can get a window into things like carnitine and Co Q10 ’cause they also play a major role in the electron transport chain. So we get a good window with how the mitochondrial function functioning by looking at the B vitamins and looking at a lot of these nutrients and so essentially things that can impair this. As you mentioned, pesticides. Heavy metals, mold toxins, antibiotics, and all these things have a negative impact. But that’s kind of how things look, so we have. Glycolysis is the first part that then goes into the mitochondria, and then we have Krebs cycle and electron transport chains. These are the big three. If you can kind of zoom out and see how it looks and how it makes sense. That should hopefully make more sense, so on that front. Any question that, Evan?

Evan Brand:  Well people listening to that. They’re going to be like wow, this sounds like a really crazy rare problem, right? This must be just rare. This must be like a one in million case and I would say. Not going to say 99. I would say 90% of the people we work with. I see some level of mitochondrial dysfunction or damage either on the chemical profile test, so that’s something I alluded to earlier. We can run chemicals so we can look at gasoline. We can look at xylene. We can look at phthalates, all sorts of organophosphates. 24D is a major herbicide. I still see people at Lowe’s and Home Depot in the Garden Isle buying grass seed. That’s called weed and feed, weed and feed is a grass seed mixed with three different types of herbicides. It’s 24D, I believe it’s dicamba and glyphosate. Wait, I could have mixed one of those up, but either way, it’s three different chemicals, very toxic substances mixed with grass seed, and that’s like people just buy it and they don’t think anything of the term weed and feed. That means you’re going to be killing all the good stuff in your soil and poisoning yourself at the same time. It’s just not smart. So this mitochondrial thing. My point was, this is not rare, like when you show that image and people see that like. Oh no, that’s not happening to me. It’s like it happens every day, all day. I had mitochondrial damage, my latest test shows our mitochondria are much, much better, but I had significant mitochondrial damage from my mold exposure.

Dr. Justin Marchegiani: Very interesting, I want to highlight one thing here so you can see creatine does primarily exist here in the cytosol, right? So if we zoom out, right cytosol is outside of the mitochondria, right? Right glucose, pyruvate here, so just so you guys can highlight here, creatine does go from the cytosol and it can go into the mitochondria. So, we did talk about creatine. It does primarily happen more in the cytosol outside the mitochondria, and it can go in via this. Mi-CRT kind of transport. Compound, so yeah, so creatine is a compound that we talked about that goes outside but can also go inside the mitochondria. To yeah Doctor Neil Nathan.

Evan Brand: That’s awesome! Doctor Neil Nathan did a huge thing for 155-page slide show that people can look up just called the Cell Danger Response. It’s very complex stuff. There’s going to be maybe a few geeky on that. People want to dive into that, but for your average person there’s not much takeaways built into that. But if you want to look into more of like the biochemistry side of it, then then you could look at it. But I think the big summary is it’s all. It’s all the Chemicals, and this is a relatively new problem I mean we face now over 80,000 chemicals are in the environment. Depending on what number you read, there’s only a small amount of those that are even tested. You’ll see stuff in Europe like oh Europe has banned these chemicals and makeup and personal care products, but the US was very far behind. And if you look at the environmental working group, they have a water testing report. You can look at and you can plug in your zip code. I mean just the amount of trihalomethanes’s pesticide herbicide residue pharmaceutical drugs that are in the municipal tap supply in your city are massive and you’re getting hit with this all the time. If you go to a restaurant and you eat rice, what do you think they make that rice with? They make it with tap water so you’re getting exposed to it that way too, which is why if I go out to eat, I don’t really do rice that often anyway. But if I do it, It’s going to be at home with good, clean filtered water.

Dr. Justin Marchegiani: I like it. Anything else you want to say on that, so obviously get the toxin exposure. Super important hydration obviously really important to anything else you want to say on that?

Evan Brand: Yeah, you hit you hit the the Co Q10. You mentioned some of the markers we’re going to look at on the oak test, so we will use those. We have a formula. I believe you’ve got 1/2 mines called my to boost. It’s essentially like a multi for the mitochondria with all the Co Q10, ribose, carnitine B vitamins. So, when we see mitochondrial dysfunction, we can supplement that and we tell people this is a band-aid for your mitochondria. This is not some of it is the root cause, right? If you just are simply low and depleted in Co Q10, one could argue supplementing Co Q 10 is the root cause, but in reality it was usually. Oh here we go. Let me see if I can share this slide with you. Mainly it was the the toxins that led to this so let. Me share my screen really quick.

Dr. Justin Marchegiani: And there is going to be because we do make Co Q10 on our own via the mevalonic acid pathway. And of course, as you get older, just like stomach acid, you’re gonna make less of it and so there there could just be a depletion based on age as well.

Evan Brand: Does that show up at all on your side? The video is that screen share show.

Dr. Justin Marchegiani: Try again.

There’s like a little bell there. Let me let me pop it up again. How about that, yes? Oh yeah, let me let.

Dr. Justin Marchegiani: Me highlight it, go ahead.

Evan Brand: Yeah, there we go. So, this is this is kind of what I was alluding to, and many many other people may have different ways to look at this, but this is from Neil Nathan. He had a great paper on this cell danger response and it just shows at the top here. Basically, everything I already mentioned like a flame. Heavy metals, pesticides, infection, so that would include viral issues as well. Mass cells, NK killer cells, cytokines, the microbiome. All these issues here are what really breaks this role. You know, the one of these is the final straw that breaks the camel’s back and then you end up in this what’s called the cell danger response phase. And then that’s where you get the issues with the mitochondria down regular. So there’s more in that. Like I said, it’s 155 pages. It’s like you got to be, you got to be, you know, have your bulletproof coffee before you look through that.

Dr. Justin Marchegiani:  No, that makes a lot of sense, so your kind of really focusing on the toxicity and how that negatively impacts it. I want to just kind of tie in the dietary component. Why is food so important to enhancing the mitochondria? Let me let me break that down for a second here. This is important. OK, so this is really important. We talked about like Kreb cycle right? And so like this is our zoom out right? What’s happening here? We have glycolysis, Krebs cycle, electron transport chain outside of the mitochondria with the cytosol inside. Now check this out. This is a good one. This is from textbook of functional medicine, so. We have fats, carbs and proteins. These are our primary nutrients where everything comes from right. Fast could be coconut oil, grass fed butter could be fats from. Uhm, grass fed meat right? Our carbs can be vegetables, fruit, starch and our proteins could be protein powder or it could be animal protein, right? All of these essentially shuttled downstream. Fats get carried into the mitochondria via carnitine, so if you go into any biochemistry textbook, it’s called the carnitine. Shuttle right. Every medical doctor, doctorate level person would studied this at a graduate level. I studied as well now in the textbook of I think that guidance Physiology, but there’s another textbook of biochemistry that’s common at the graduate level. You know what the rate limiting amino acids to make carnitine are. It’s methionine and lysine and so really important.

Dr. Justin Marchegiani: Guess what some of the rate limiting amino acids are in a vegetarian diet.

Evan Brand:  Oh yeah, well.

Dr. Justin Marchegiani: Medallion Leisinger actually very deficient in vegetarian diets, and so this whole process of a carnitine shuttle here that helps bring carnitine converts it into acetyl Co A. So then the actual it can get inside the mitochondria. And run through the citric acid cycle again. That’s the same thing as Krebs Cycle. They have multiple names. In medicine for the same thing, it’s just meant to confuse people. So citric acid cycle or the Krebs cycle.  This is how we get fat inside the mitochondria is via carnitine. So very important, right so if we zoom out. Here, we have energy out here, fat. We get it inside via the carnitine shuttle. Super important there and then you see carbs. Right glucose, other sugars. We go pyruvate to lactate and we need guess what B vitamin? So if we’re putting in lots and lots of refined processed sugar and we’re insulin resistant, we can actually deplete B vitamins. And we can actually deplete a lot of magnesium and other nutrients downstream. So, this is really important. Too much carbs, too much sugar, especially if you’re insulin resistance and you’re putting on weight due to too much carbs. That’s going to be a problem, and you’re going to deplete nutrients now. Then we have proteins, amino acids. These all get converted downstream. We also need B itamin to support that now the difference is if you’re eating high quality protein. Guess what? You’re getting good quality B vitamins in that. Protein if you’re doing a lot of refined processed sugar, guess what? You’re not getting vitamins and nutrients with it. So carbohydrates, it’s possible to eat a lot of empty carbs that are actually going to deplete your nutrient levels. Protein not as much if it’s grass fed and organic right now, really, you’re taking all these nutrients, fats, carbs and proteins. You’re converting them into acetyl Co A. OK, you’re converting it to acetyl Co A and again we spit off beta-hydroxybutyrate what’s that? That’s a ketone now this is important. If we keep our carbs in check we can use ketones for fuel, so this is a really important fuel source or people that are going to be lower carb because we’re going to be more keto adapted. We’re going to be able to use that and then you can see here that acetyl Co A. Runs around the Krebs cycle. Twice we go 2 turns. Guess what, we need cysteine amino acid iron really important. So if you’re a female you have heavy bleeding your estrogen dominant you heavy bleeding that’s in effect energy magnesium manganese B vitamins lipoic acid magnesium B vitamins B vitamins tyrosine phenylalanine aspartate, glycine, histidine, arginine, proline. Glycine, valine methionine, right? These are all amino acids over here. So, we need amino acids to run these systems. We need B vitamins. We need magnesium and then of course, once we pump these things around, here’s our NADH and then our FADH should be there somewhere as well. So here NADH, it may not. They may just be oversimplifying it not showing it. But we have NADH here. We should have an FADH2 coming in. This all goes right into. Guess what? This is the electron transport chain and base. Yeah, fatty acid oxidation right there, right? This is now now hydroxymethyl Glutarate. This is Co Q10. This is where Co Q10 comes in and this is where it runs through the electron transport chain and burning fat for fuel and we generate our 36 to 38 ATP from all these three sources 1-2 and three and so that’s what’s happening in your mitochondria. So just to kind of highlight macro nutrients, fats, protein, carbs, very important two, don’t junk it up with all the toxins that you mentioned. And then of course, making sure we. Can breakdown protein. Make sure we’re getting enough iron making. Sure, we’re not. Anemic right? All of those things kind of flow into allowing all these pathways to to work optimally.

Evan Brand: That’s amazing, I love the breakdown to that. The visual super helpful. So just to clarify a little bit. So for women out there, you’re saying that if having heavy ministration, they have low iron. It’s not just the the low iron that we assume is creating like a low oxygenation, you’re you’re showing here. The low iron is literally creating a mitochondrial deficit.

Dr. Justin Marchegiani: Correct. You’re not getting the oxygen in right? If we go back to here, right? Mitochondria, what do we need to get into the mitochondria? Oxygen, what’s one of the big carrying capacities for oxygen in the body? Hemoglobin and then iron affects hemoglobin in red blood cells, right? Hemoglobin is part of the red blood cell carrying capacity and we need the iron to really keep the hemoglobin levels up so we can carry enough oxygen.

Evan Brand: Wow, so there’s why you’re tired.

Dr. Justin Marchegiani: Could be. Yet, one and then of course all of the other nutrients play a role. Not enough of the amino acids. The only issue with this graph, any biochemists that are looking on? I think the only thing that’s missing is really the FADH2, so it should. So, all these things, they’re just reducing compounds. Really, the whole goal of this Kreb cycle to run is just grabbing hydrogens. And then once we grab these hydrogens, Uhm, these things get cleaved off, and then it generates ATP. What’s happening there? And all these things like hydroxymethyl iterate. These are right. These are all driven through Co, Q10, right? We need Co Q10 to make that happen.

Evan Brand: Now for people like supplementing ketones, if you go back up to the top there, you can basically kind of inject your own spark plug into the cycle, I guess right? If you’re taking exogenous ketones, what is that doing in relationship to this whole cycle?

Dr. Justin Marchegiani: It’s giving you more beta hydroxybutyrate. The problem is your body is going to primarily want to use that when insulin levels are lower, so you have to keep your insulin levels and check. If not, you’re not setting your Physiology up to want to burn that. If you’re probably, gonna pee it out more like more than likely versus burn it. Cause typically, your body has an enzyme called hormone sensitive light pace where it wants to break down fat and convert more of these ketones. Hormone-sensitive light base is inverse with insulin. So hire your hormone-sensitive light pace is you need lower insulin to make that happen.

Evan Brand: So the lady who eats the donut and then goes to the store and buys her exogenous ketones, she’s wasting her.

Dr. Justin Marchegiani: Probably not as good. There may be some mild benefits that you get cognitively just ’cause your brain has some additional fuel to run on. If people brains are insulin resistant, they may have a lot of sugar from that doughnut, but the cells in their brain maybe so numb. To it that they may not be able to access it so some ketones could be helpful, but in the end, you want to fix the insulin resistance if you’re going to do it. Try doing both. Don’t just do the ketones. Try to do both that you can.

Evan Brand: And you can make your own ketones too. For free.

Dr. Justin Marchegiani: Yeah, yeah, that’s how you’re doing that you keep in your insulin in check. And you’re going to start. Making your own. 100%.

Evan Brand: Yeah, cool.

Dr. Justin Marchegiani: Cool, that was awesome. Very cool guys. I hope you guys enjoyed today’s podcast. We’re trying to be a little bit more visual; you know. Go into some hard hard science Y stuff, but you know just kind of zoom out. Like what’s the take home right? The take home is don’t put junkie toxins and that screw up your mitochondria right? Antibiotics, I mean antibiotics? You know if if you have an acute infection that’s not resolving, you know you gotta do what you gotta do, right? You have an acute pneumonia. You gotta do what you gotta do. Talk to your doctor about it. Just don’t go to antibiotics all the time as your first line defense. Try to do some. More natural things to fix it #2 you know, try to be aware of mold in your environment. Make sure you’re not. Getting exposed to pesticides. Chemicals heavy metals. Make sure you’re doing your best to hydrate right. We need water to make this whole thing work too. I would say after that make sure you have your macronutrient style, then good quality protein fats and carbohydrates. Organic sources dial in your carbs so you’re not insulin resistant and make sure your inflammation is good. Inflammation helps with oxygenation and blood flow. Then after that we can look at using supplemental nutrients in my line and Evans line we have mito supports products mine is mito synergy. Evans is my toe. Boots will put links down below. Those products have a lot of these nutrients. It’s going to have the ribose to creatine the carnitine, the B vitamin. Since it’s going to have the Co Q10, it’s going to have actually Kreb cycle intermediary compounds like fumarate malate, succinate. All those different nutrients or run those pathways better. Of course, that all sits on top of a solid diet. Don’t take supplements if you’re going to eat crap, eat really great and then say OK now I’m going to work on enhancing it. And again, we can run testing on organic. Message to look at some of these intermediary nutrients, like citrate to connotate succinate bloomer, a mallet we can actually test them, which is pretty cool.

Evan Brand: Yeah, the testing is the best part because you you know if you actually need it. I can tell you the average person has mitochondrial problem, so in general, could you just take this? I kind of call it a multi for the mitochondria. Could you just take that test? You know like a guess and check you could, but we like to see the data and obviously my biggest thing is looking for mold colonization. Candida overgrowth clostridia. Some of these gut infections and how that affects your brain chemistry too. So when you do the oh, you really are getting the best bang for your buck in terms of testing. Like if you could only do one test out there, I think the oh it would. Probably be the number one most.

Dr. Justin Marchegiani: Important 110%. Anything else you want to say?

Evan Brand: If people need help, they can reach out to you worldwide or me worldwide. Doctor J at justinhealthcom me Evan at and we would love to chat with you about your symptoms, your goals and we’ll tell you for your good fit for care, so please feel free to reach out. Look forward to helping you.

Dr. Justin Marchegiani: Foot and get adjusted. Help calm here and then you guys have any questions, comments or concerns. Put him down below. Let us know. Kind of what you’re doing. What’s working that really helps us out as well. Very cool. Alright guys, well you guys have a phenomenal day here and we’ll. Be in touch. Take care of y’all.

Evan Brand: Sounds good.

Dr. Justin Marchegiani: Alright Bye bye.


Audio Podcast:

Recommended products:

Mito Synergy

Mito Boost

Deluxe Mold Test Kit

GPL Mycotox

Genova Organix Comprehensive Profile

Genova NutrEval FMV


How Your Diet And Blood Sugar Can Weaken Your Adrenals | Podcast #340

Changes in blood sugar levels may be a sign and symptom of adrenal fatigue. In the early phase of adrenal fatigue, you can see hyperglycemia (high blood sugar) and, in an advanced phase of adrenal fatigue, hypoglycemia (low blood sugar) is the usual presentation. 

The thing is, you may not notice a problem with your blood sugar levels, but that doesn’t mean it’s terrific. It is essential to monitor and know the symptoms of having a diet full of food content that send your blood glucose on a roller coaster ride of high and low levels. These glucose level swings can result in damage to your blood vessels, raising your cholesterol, and put you at risk for heart disease.

Dr. J and Evan recommend having yourself tested (not guess) and checking the food you include in your food template because they can be the reason for your chronic issues for so long.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

1:47    Adrenal Blood Sugar Physiology

9:26   Intermittent Fasting, Carnivore / Keto Diets

18:45  How Intermittent Fasting Helps

24:43  Hypoglycemia and Adrenal Stress

31:08  How Mold Affects Adrenals

35:00  An App that Helps Monitor Your Diet

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Dr. Justin Marchegiani: And we are live. It’s Dr. J here in the house with Evan Brand. Today we have an awesome podcast topic on the queue here, we’re going to be chatting about how your blood sugar can weaken and negatively impact your adrenal glands, we’re going to be talking about blood sugar, how it affects your immune system, how it makes you either strong or weak, we’ll be talking about nutrient supplement changes that you can do to help with that, as well as diet and lifestyle changes. So I’m excited to dive into this topic. This is a relevant topic that we are applying and seeing with our patients every day, especially ones that have adrenal issues, or adrenal and cortisol imbalances. So really excited to chat about this. And what’s happened today, man?

Evan Brand: Hey, not too much. Let’s dive right in. So let’s set the stage for people. This is a conversation that maybe didn’t happen. Historically, we didn’t have the chronic 99% of the time, we’re stressed and 1% of the time we take a vacation, we didn’t have that kind of lifestyle historically. And so I think now, you’re kind of talking about this with me, before we hit record, the average person is just so toxic, they’re so stressed. They’re sleep deprived. They’re on stimulants like caffeine, and they’re having these spikes and crashes all throughout the day, pretty much everyone is on both the stress rollercoaster. But they’re also on this blood sugar rollercoaster too. And that really affects the adrenals over time. So that’s where I want to set the stage with people is that we’re in a society that’s doing quick fixes. When we feel a blood sugar crash, we go when we eat the organic cookie. Now it’s an organic cookie instead of an Oreo, or it’s a gluten free cookie instead of an Oreo, but it’s still a cookie, and then you end up crashing again. So I want to set the stage of even though you could be doing paleo or similar diet, a lot of people are still having issues of blood sugar regulation, and we think adrenal is is is one big part of it, which is then connected to the gut. So really, we could make this thing like a three hour episode, but we’re going to try to condense it to half an hour.

Dr. Justin Marchegiani: Absolutely. So let’s kind of do like an adrenal blood sugar kind of one on one physiology review for people just kind of coming into this. So your adrenal glands produce a hormone called cortisol, right, which is a glucocorticosteroid. Big word right, the first half of that word is glucose, meaning it helps pertain to blood sugar and energy. And so the more your blood sugar debates goes up and down, the more hormones have to be produced to buffer the highs and lows. So the more we keep our hormones snaking along, or we keep our blood sugar at let’s say in this example snaking along or stress snaking along throughout the day without big up and down spikes. Our hormones are called to the rescue far less. So. If I eat, let’s say one, I’m not eating at all. Let’s say I’m fasting, right and I’m not really good at being fat adapted, your blood sugar is going to drop and when your blood sugar drops, that creates a stress response. The first thing that happens on this low blood sugar drop is going to be a spike of epinephrine or adrenaline. Right? So epinephrine or adrenaline is like the key catalyst to wake up and call cortisol. So you get this epinephrine or adrenaline or catecholamines surge again, they are all the same thing. You have epinephrine, norepinephrine, you have adrenaline, you have noradrenaline, you have catecholamines. They’re all the exact same thing, same name. They’re just meant to confuse people. So just kind of put that out there. If I use these words, they’re 100% interchangeable, okay. So you’re going to have this surge and adrenaline. And that’s going to bring up your blood sugar when it brings that blood sugar up. This is when you may feel anxious. heart palpitations, this is May when you get a little bit dizzy, nervous, sleepless, irritable, right, sweating, you know. So when you start to have when you’re on those blood sugar rollercoaster, when this blood sugar drops and starts to come back up, you may have symptoms that make you not feel that well. And so then, of course, what comes up after that adrenaline surge is then cortisol is now going to help bring it up the rest of the way. So think of adrenaline is the it’s the, it’s the first responder, right. It’s the person on the operator line, getting the police ready to come to your home and then the police to come 1020 minutes late, that’s cortisol. Okay, they come a little bit later to the show. And so that’s important. So when you understand your physiology, that’s, that’s good. The next component is when your blood sugar goes back up on the high side, that’s where you make a whole bunch of insulin. So insulin can make you feel tired, it can make you feel fatigued. Insulin activates a lot of lipo Genesis, that’s fat storing lipo, meaning fat Genesis, creating and so when you start to have when you’re on a blood sugar roller coaster of high to low blood sugar, okay, this creates this high level of insulin, a lot of label Genesis that creates fatigue. And then of course, when you have a high level of insulin that brings your blood sugar back down, because insulin is opening up the cells trying to get blood sugar into the cells to either burn it or store it. And if you’re not active, and your cells are already full of glycogen, and you’re not actively doing something like walking or running or lifting guess what your body then shunts and partitions that fuel into the storing phase. So if you’re active, great, you’ll burn it. If you have muscles that have glycogen storage, you’ll convert it to glycogen which is glucose. Storage sugar storage. And if those two capacities are tapped, then we start going to fat storage starts going more to life with Genesis. So we’re on this blood sugar rollercoaster. So high blood sugar up high blood sugar up, a lot of insulin drops it down, right, then we have this, this really high drop high to low drop, this then stimulates a lot of adrenaline, catecholamines and then cortisol in the app, this is called reactive hypoglycemia. And then the other type of glycemia issue that we’re going to see is going to be usually fasting too much not eating enough low calorie diets, skipping meals, that’s more like this, that’s your blood sugars like this. And it just starts to drop into this hypo category, you know, maybe below 75. One goes up first. That’s the reactive, it’s reacting going high and then dropping, that’s reactive hypoglycemia, that’s typically going to happen due to poor diet, too much sugar, too much carbs, not enough protein on a fat. And then we have just general run of the mill hypoglycemia, usually from poor meal timing, skipping meals, too much fasting, typically low calorie dining. And again, if you’re doing a lot of intermittent fasting, but you’re low calorie in general, throughout the day, that can easily drive low blood sugar too.

Evan Brand: Wow, well said so the average American, they’re experiencing more reactive hypoglycemia because they’re on sodas, they’re on the Milky Way bar and hiding in their desk drawer at lunch, the person listening to us who’s hopefully relatively dialed in, they’re going to just be more in the standard, we’ve just called to us maybe a standard hypoglycemia situation. And then how do the adrenal is play into that? Because what you’re saying is happening is that, let’s say, and this happened to me, I can tell you firsthand what happened. But what kind of open it up. So intermittent fasting, you’re saying that could could drive that and you’re saying there, you’re kind of hinting at the fact that maybe the adrenals are too weak to help you’re seeing the adrenaline can be released, and it’ll crank it up. But you’re saying, Okay, I got like a recording, stop and start. So just making sure we’re good. Okay. So you’re saying that, in a normal situation, the hypoglycemia can start to happen, adrenaline should come up, kind of bump you up, give you the little nitrus booster, but you then you need cortisol to push you to the finish line. But you’re saying in the case of adrenal stress, the cortisol may not be able to get you up to the right amount. And that’s how an intermittent fasting situation could be not good for you. Is that right?

Dr. Justin Marchegiani: Yeah. So then if you don’t have good adrenaline output, or catecholamine, output, like so how do we know that as we look at organic acids, if we see imbalances and vandal Amanda later home of anolyte, these are amino acids that are precursors for dopamine and adrenaline. And again, dopamine is a precursor to adrenaline. So when you’re constantly stimulating adrenaline, you’re actually pulling dopamine down. And dopamine is really important for satisfaction, mood focus, right? So if you’re chronically stimulating adrenaline, you’re going to have adrenaline issues, you’re going to have dopamine issues that can create a whole bunch of problems. We’re going to know that because we’re going to see an organic acid test showing a lot of imbalances in those catecholamines. And if our blood sugar, if we have very low cortisol, we run a good quality Dutch test we see chronically low free and total cortisol, it’s going to be hard for our body to bring that blood sugar back up and we can kind of stay a little bit more hypo. And that can cause that irritability, that faintness, that fatigue, cognitive issues, mood issues, brain fog, it can create all those problems. So if we don’t have good when people talk about adrenal is people mostly just think about cortisol. When it comes to adrenal, they don’t think about the adrenaline catecholamine dopamine connection. And so when we talk about adrenals, we have to really look at the outer part of the adrenals. That’s the cortex. That’s where cortisol lives, that’s where aldosterone lands because we’ll talk about it in a minute. aldosterone plays a big role with minerals and holding on to minerals. And if our minerals go low, like we see in pots, right, which is a postural orthostatic tachycardia syndrome that has to do with minerals being low sodium chloride, potassium, right, that can create a lot of symptoms similar to hypoglycemia. And so we have to look at the the cortisol component, but also the adrenaline the adrenaline tends to happen more in the medulla medulla M for more middle part of the adrenal gland. So it’s good to look at both and that’s where having a high quality adrenal test that looks at free and total cortisol, as well as an adrenaline, dopamine via the organic acids to look at what’s happening with the catecholamines and neurotransmitters.

Evan Brand: So how would this work? Let’s say if you weren’t doing intermittent fasting, let’s say you switched off of that maybe you were having these hypoglycemia episodes, the adrenals. were too weak to give you the cortisol output you wanted. So instead of intermittent fasting now you’re just doing like a carnivore breakfast, maybe you’re going to do a grass fed steak or maybe you’re going to do some pastured eggs or some pastured bacon. Is that enough to pull you out of that? Are you going to need some support? Would you recommend we throw in like a little bit of honey, some blueberries, you know, maybe something else to pull you out of that spike like is meat is meat enough? I guess is the simple question.

Dr. Justin Marchegiani: So what happens with proteins that you’re consuming is your body is going to be able to one, it’s going to be keto adapted. But again, not everyone’s keto adapted, you have to be metabolically flexible to be keto adapted, where you can actually take a lot of the fat, right, you have a glycerol on a free fatty acid, and you’re able to break that down, pull off some ketones and start burning more fat for fuel. A lot of people just can’t transition to that, because they’re very metabolically inflexible. And so protein and fats not going to be a viable source unless someone’s really dialed their diet in for two to four weeks, and really had that metabolic adaptation. Now, some people, their their insulin levels just dropped to low, and let’s say maybe below four or so or even below two on a fasting insulin test, they may need more carbohydrate. And, again, if they’ve been doing the diet for a month, and they’re in there, they’re having good proteins and good fats at every meal. And maybe their carbs are really low, we may want to add a little bit more starch in because sometimes they feel better doing that because it actually blunts the cortisol spike or the adrenaline spike that the body is trying to create to mobilize that glucose. So it’s like, we can add a little bit more carbs in via healthy, safe starch. And that blunt some of the cortisol and the adrenaline is being produced to mobilize that internally, some people, their insulin levels are really high. And by keeping the carbs super low, they’re bringing their insulin back into the sweet spot, and they’re actually good. And then when they add more carbs in, they actually feel worse, because their insulin is going out of balance, and they’re starting to get more into fat storage mode. So most people I find tend to be more on the insulin resistance side. So I always default to lower carbohydrate out of the gates, and then fine tune later once they kind of hit the wall. And you know, a good way that to see how you know, if you’re hitting the wall or not, is get to a place where you’ve been doing it for a month or two, make sure your body is pretty good at burning fat, right? So you’re eating good proteins, you’re eating good fats, that initial keto flu is over right, that first couple of weeks of getting fat adapted headaches, mood issues is over, then you can try adding a little bit more carbs in maybe at night. Have a sweet potato, a little bit of white potato, a little bit of a say starch, see if you feel better or not. If you sleep better, if you have more energy, if your workouts are better, recovery is good, that’s a good sign that that’s better for you if you don’t feel better. Or let’s say you’re you know, you’re very overweight, and you probably want to work on keeping the carbs in check longer, again, the benefit that you have with good fats and proteins, it’s hard to over eat when you’re eating good fats and proteins, because there’s good satiation signals to your brain that tell you to be full. That’s like peptide yy, adiponectin. coli cytokinin. There’s really good feedback regulations, people are like, well, it’s all about calories in calories out, it’s like, but not all calories, tell your brain that you’re full the same way. So you have to look at the the epistatic regulation of appetite, right and certain neuro peptides are going to be produced with certain foods, you’re not going to get that same stimulation, eating pizza eating Pringles drinking refined sugar, you’re not going to get it. And that’s why it’s so easy to overeat those foods, and you never really feel satiated, try eating you know, half a dozen eggs with you know, cooked in butter, it’s gonna be really hard to still be hungry afterwards. As long as you don’t eat things too fast, where people really go awry with proteins and fats is they eat things too fast, is about a 10 to 20 minute delay in those kind of chemicals telling you you’re full. And you really have to give your body that 10 to 20 minute buffer time. So eating slower, chewing your foods up really well, not overly drinking, when you consume those foods, giving yourself five or 10 minutes once you finish your meal before you get seconds. That plays a big role, because it’s really easy to overeat with these foods, when you don’t give it enough time. 

Evan Brand: Yeah, look at the marketing of potato chip companies, veggie candy, just one, they know that you’re not going to get leptin and all these other beneficial compounds and tell your body your full. So the marketing companies know what they’re getting into, they know you’re going to eat a whole bag of chips, because you’re never going to get that signal that you’re satiated. And that’s where you’re going into trouble. So let’s go back to the adrenals for a minute. So you mentioned running a Dutch panel looking at low cortisol. So what you’re saying is if you’re going to see a flat panel, or maybe just maybe it’s not flat, maybe there is some sort of peak on the cortisol in the morning, but it’s very weak. So overall, you would just say there’s a low cortisol output, you’re saying those people are going to tolerate intermittent fasting less, those people are going to tolerate very low carbs less so they may need a little more bump while they get their adrenals back on board. Is that safe to say? 

Dr. Justin Marchegiani: If their cortisol is really low? Yes, it just depends kind of where they’re coming from. Right? If they’re coming from being overweight, being more insulin resistance, being more tired, being more fatigued out of the gates, always in a default to lower carb. If they’re coming from already being at a reasonably healthy weight and being pretty active already. Then I’m going to default to adding a little bit more carbs and so it just depends upon where someone’s coming from. So it’s always good to look at someone’s Samantha type right? ectomorph endomorph mesomorph right. endomorphs like The linemen write in football. And again, this can be like any one, but they’re just have a larger, higher propensity to put on weight, write the message, or then they have the ectomorph. This is more of the natural kind of basketball player type, they’re just more taller and more leaner, hard to put on muscle, hard to gain weight. And then you kind of have a blend between an ectomorph and an endomorph, called a mesomorph. Think of that as the M for middle, right. And this is kind of more like your linebacker in football, right. And again, these are extreme examples, but helps to kind of tell the tell the story, right? Not everyone’s a 300 pound lineman, I get that, right. But people have this propensity to put on more weight. But a mesomorph, someone that’s kind of more in the middle, like they could be taller and leaner, but they also can be bigger as well, they’re kind of in between. So usually, people are in one of the three of these categories. And usually, if you’re more on the ectomorph side, you’re going to be able to tolerate carbs pretty well. So that you have to just kind of like you know, see kind of where, where you feel best. And there’s a lot of people out there like let’s just say let’s people on the diet side, I’ll just I’ll call Chris kresser out, right? Chris? kresser is a ectomorph. Right? suit. You know, Paul jammin a ectomorph. A lot of people out there that like recommend more carbs, more higher carbs, more whole food, carbs? And it’s like, well, of course, you’re going to recommend that because you’re an ectomorph, of course, right? So you have to look at the people that are recommending certain things and look at what somato type they are because certain somatic types are going to have a propensity to handle macronutrients differently than someone else. So it’s good to look at that as a general template. But in the end, you got to fine tune it, you got to look at it, my default way of looking at because of insulin resistance is being so prone, because refined and processed foods have been eaten ubiquitously, you know, over the last 20, if you look at the macronutrient trends over the last 20 or 30 years, right, its proteins gone down a little bit fats has actually gone down a little bit. And actually cards have gone up. So when you look at that general trend, we can just assume out of the gates that most people are going to have carbohydrate problems, not protein and fat problems. And if they do have protein in fat problems, it’s usually from junky trans fats and or junky omega six refined vegetable oils, not healthy animal fats. 

Evan Brand: Yeah, very, very great points. And that’s important for people to listen, I mean, you’re hearing a clinician speak, you’re hearing the clinicians brain, because as you mentioned, if you get into some of these other people that may not be practicing clinically with people, they’re going to be able to give you a cookie cutter answer and you did not I was kind of probing you to give me some like buzz wordy, you know, like something I could post on Twitter type answer, but you gave me a clinicians answer. And I hope people appreciate that. Because there’s a lot of variants with this. And I know it’s frustrating, because when you listen to a podcast, you’re like, I just want to be told what to do how to do it. Give me the sparknotes? And your answer is there’s not really a sparknotes there are some categories, if you will, that we can put people into I’m definitely probably closer to ectomorph. And so I do better. Like if I do a grass fed steak and I throw some extra organic wild blueberries in with that for breakfast, I feel so much better with that extra little blueberry hit, as opposed to just the steak versus let’s say, my grandmother who had an high a one c score, she’s going to do much better with just the steak and she’s going to go but better lower carb overall.

Dr. Justin Marchegiani: Exactly. So it’s good to know, I’m kind of more of a mesomorph I’m kind of in the middle. And I just I look at you know, the problems that we as society have as a whole, generally speaking, and I kind of just create my recommendations to have the largest bang for the buck regarding the average person. And then of course, when patients come in, then you kind of look at them, you kind of look at their height, their weight, you know, especially you see a lot of women, you know, in their 40s. I’m like, well, where were you in high school in college it regarding your weight? Oh, I was 80 pounds lighter. Okay, so we know there’s some metabolic damage there. If you put on 80 pounds since that time, right. So then, then it’s good to really make sure we we support them being better fat burners, I think the next step I wanted to hit would be intermittent fasting. So someone in the comments here will talk about this, they talked about omad, or one meal a day, I’m not a huge fan of omad. Now people can do it, if they’re wanted, they have pretty good adrenals their diets really good and they’re very metabolically flexible. Okay, with omad. It’s one meal a day. So you need all of the calories that you need in one day in one meal. So number one is you’re going to be eating a meal that’s like two to three times bigger than what your typical meal would be. Because if you need, let’s say, you know, I’m six to 2015 pounds, right? I need like 3000 calories a day, if I’m you know, relatively active, well, 3000 calories is a lot of food at one meal. Okay, it’s a lot of food. Because you need your your micronutrients, you need, you know, your amino acids, I need probably at least half a gram per pound of body weight minimum for protein. So I need at least let’s say 110 grams of protein, that’s a big meal. So one, you need really good digestion, you probably needed over an hour to sit down and actually eat that meal if you’re not going to be sick because that’s a lot of food to eat at one time. So you probably need an hour to eat it. You need really good digestion really good enzyme and acid secretion. You need an hour to sit down and be able to handle it and you probably can’t move much for an hour afterwards because the meal so big, it’s it’s the equivalent of a Thanksgiving Day dinner. Right? And so you got to be careful with that.

Evan Brand: I think let me just give you a little I’ll give you some numbers real quick just to show how hard what what you’re describing would be. So for example, I love bison. So if you were to do a which this is going to be your fattiest cut, if you could do a bison ribeye, a 10 ounce bison ribeye, you’re going to get roughly less than 500 calories, maybe like for something like 450 to 480. So if I just did it as 10 ounces. So I mean, God, let’s say you did 20 ounces, which would be very hard for me to do a 20 ounce bison ribeye, you know, you’d be maybe close to 900 calories.

Dr. Justin Marchegiani: Yeah, and so you’d probably need at least you know, if for me, right, you’d probably want about 25 to a third of your calories coming from protein right around there. And so you’d probably want about that steak would probably have to be about 20 ish, maybe a little more ounces than that. That’s a lot to do at one time. And that’s not including the six to seven servings of vegetables that you may want to do with that as well.

Evan Brand: And then what Yeah, I was gonna say, and then what else are you going to do? Let’s say you did like a cup of broccoli, that’s like 40 calories.

Dr. Justin Marchegiani: Exactly. So you need like literally eight cups of that or like, you know, 60 it’s becomes really hard. 

Evan Brand: Yeah, cuz I see why you don’t recommend it. So so your overall, your overall messages, you think maybe two meals a day, you could get away with a one meal a day you think for this type of conversations can be really tough.

Dr. Justin Marchegiani: Yeah, two meals is good. Two meals, you can do it in the morning, I mean, you may want to have like a little bit of bone broth, or something very gentle on the liquid side. Again, if you’re just trying to do intermittent fasting, it’s easier to do one, I don’t recommend it every day. But it’s easier to do like, you know, keep your eating window between 12 and eight, or let’s say two and eight, I think it’s easier that way gives you enough time to have a meal at two o’clock, five o’clock, or let’s say to, let’s say two o’clock, six o’clock, and maybe a little snack before bed, if you’re still hungry, you want to fill in the gap, right? So it’s a little bit easier from a nutritional standpoint to get your needs met. Again, if you’re having a lot of hormonal issues, I don’t recommend doing a lot of fasting out of the gates. Think of fasting as a stressor, it’s a stressor on your body, just like exercise is a stressor. So imagine your personal trainer, someone’s like super unhealthy. They’re out of shape. And you’re like, hey, come to my CrossFit class tomorrow, I’m 100 pounds overweight, come come across it, it’s like well, you know, with their weight being where they’re at, and how inflamed they’re at, they’re gonna be like, literally in bed the next week, with sore joints sore back totally hurt. So you have to make a recommendation based on what’s best for them. So you may say, hey, let’s just do like a 10 minute walk tomorrow, right? So a 20 minute walk, let’s say a five minute walk after every meal, that may be a better recommendation, right? So think of like the Oh, Matt, or like a lot of this intermittent fasting. That’s the equivalent of jumping a very overweight, unhealthy person into CrossFit. It’s the equivalent, it’s still a stressor on the body. Now, if you’re healthy, guess what? It’s a stressor that you can adapt from and get up and get stronger. But if you’re not healthy, that stressor is going to break you. And so you kind of have to know that, hey, this is an application of stress. And the question becomes, does your physiology have the ability to adapt to that stress based on where you’re at now? And for most people that are that we see clinically? No, that’s not gonna be the case. Yeah, there’s always weather. Yep. I always weather under Should I rather undershoot it have that person feeling better, less or less tired? And kind of in kind of gauge up then overshoot and make them feel worse?

Evan Brand: Yeah, well said. So this is the anti boot camp podcast. You see those boot camp signs? It’s like, they’ll just come in and they’ll just kick your ass on day one. I mean, they don’t care. You’re 300 pounds five foot tall. 300 pounds, haven’t walked a mile in 10 years and they’ll just come in and throw you down. Give me 50 them Yes. Boom, boom.

Dr. Justin Marchegiani: Yeah, I mean, if your life if you can come home and just like recline back and chill and read and watch TV or just hang out all day, you’re not doing much. Okay, fine. But most people have like, have to work they have to do things, they have to do chores, they have kids and family and responsibility to take care of so it’s like their life can’t revolve around that right? So obviously with the TV show and that’s what their life is, you know, you can get away with stuff when that’s what all your focus is. But for most people, you know, that’s not the reality that we’re in.

Evan Brand: Yeah, and if you want to go another direction with this, please do but I just wanted to bring up one question here that came in the live chat. And for people listening if you want to join us at the time of this recording, maybe we change the schedule but for now we go live every Monday somewhere around 11am Eastern on Dr. Jay’s Justin health YouTube channel so if you want to check them out, that’s how you can join us in the live chat question here. Does sugar or caffeine effect? I think they meant effect. The sugar caffeine weaken the adrenal is the most. I don’t know if they’re saying like either one. I would say both are a factor in people going to Starbucks and getting their dessert in the cup, which they call coffee. That sugar caffeine combo, I would say is a super big issue with hypoglycemia and adrenal stress. What would you say?

Dr. Justin Marchegiani: I think it depends if someone’s doing a cup of coffee or two in the morning and they’re consuming it with some fat and some protein like maybe they’re throwing some collagen MCT oil in there. That tends to time release, the caffeine tends to not be as big of a deal because the caffeine is going to be out of their system, you know, by the time they go to bed. So if they’re doing a cup or two, as long as they are not getting anxious, anxious or irritable, or Moody, or any of those negative symptoms afterwards, I’m okay with a little bit of caffeine. And again, if you’re on the fence, just pull it out or choose something that’s more decaffeinated. Choose a coffee substitute, like to Chino, or do a decaf, kameel or decaf green tea. See if you feel better if you don’t notice a difference where you’re not feeling worse with caffeine, a little bit’s okay. And if you want to time release it, a little bit of fat in there and a little bit of collagen, will time release it and just do it in the you know that first hour or two getting up, don’t do it in the afternoon hours. If people that get in trouble are the ones that do it usually after lunch, and they’re trying to get at that second when between three and five. And then it’s it’s causing a second cortisol surge at night because that caffeine still in their system around 10 to 11 o’clock at night.

Evan Brand: So what you mentioned is good, but your average person’s not doing what you’re you’re doing. They’re wrapped around the Starbucks drive thru, they’re gonna go get a venti caramel frappuccino with frickin whipped cream and six pumps of syrup.

Dr. Justin Marchegiani: Yeah, so what we’re talking about zero sugar in the coffee, we’re talking totally black with the exception of maybe some MCT or, or a heavy coconut cream. Or if you can handle dairy, maybe a heavy whipping cream, some kind of a good fat in there that you can tolerate. Maybe it maybe it’s just MCT oil, maybe it’s some collagen as well, because that time releases it and really allows it to go in your system slow. Someone on the chat talked about using glucose and sugar to keep their blood sugar stable throughout the day. Like that’s literally like going camping and keeping your fire going all day with paper and kindling. It’s just it’s not practical, because you’re never going to get keto adapted, you’re never going to become a fat burner, when you’re literally relying on glucose to keep your blood sugar stable all day. That’s the problem. And that’s like, you know, physiologically, the antithesis of health. Because really be healthy, you really want to be fat adapted. So you can help burn can help get energy from fat, it’s the most stable energy source, that’s not going to require up and down dips. So the equivalent of that is getting energy from logs in a campfire, which burn a lot longer and stronger than let’s say kindling a paper. So you just have to look and say, if I’m camping, the goal was I want to really get my heat from those good logs, not killing your paper because I don’t have to be feeding it all day long. That’s the difference.

Evan Brand: Yeah, and some of this biochemical talk people may dislike to now and like, turn into a zombie. So if you’re listening to this, you’re like, well, how does this actually change how I’m getting through my day. So that example that Justin’s mentioning with the really good fatty coffee versus the really sugary coffee. So this is the person who, like I know, you’ll do fatty coffees, like during our podcast, so you’re going to be burning clean, and you’re going to have a good energy burn throughout the entire morning, versus the person doing the sugary caffeine, they’re going to crash Two hours later. And then they’re going to go for maybe as this person mentioned in the comments, or they’re going to go for fruit or fruit juices or something else, they’re going to get that quick hit of kindling again, and then they’re going to crash. So when you’re at work that you’re not going to be performing at your best. I mean, if I were in charge of like a massive company, and I had the ability to give people support, I would say, hey, look, everybody can do a nutritionist console, let’s say you had like a warehouse worker. And we found that the output of the warehouse workers were 20% more efficient, if we all had them on more animal based higher fat diets, as opposed to these people. You know, when I used to work at UPS to pay for my college, you’d have these guys who on a four or five hour shift, they pull out two or three candy bars just to get through the shift. And here I was eating just my grass fed ground beef before I went in, and I was stable the whole time. These guys could work for an hour, they got to go do a bag of chips, they go to the vending machine, get the coke, and then they go do the Cheetos. I mean, it was literally it was crazy to watch.

Dr. Justin Marchegiani: Yeah, exactly. And there’ll be a lot of people out there. And this is why I talked about this amount of time to people that you’re going to see breaking all the rules that I’m saying these are going to be the vegan vegetarians, the high carbers. And when you’re an ectomorph, you can handle lots of carbs your body has the ability to take those carbs shunted in Burnet right away. And then these are the people that get energized with more carbs. Like if I if I give you a glass of orange juice and a bunch of carbs, these are the people that want to go out and literally run a marathon because their body handles carbs, and it just fuels them up and makes them so energized. And so we all have vegan vegetarian friends that just literally eat carbs all day, right? You know, you see the fruitarians that are out there. This is a big thing. I think in the 80s. at Apple, there was a big like fruitarian called they all ate fruit was like unbelievable. And you see people that are energized, energized. These are ectomorphs these are people that can handle that I still don’t think it’s healthy, I think as long term ramifications with insulin and oxidative stress. But people can do that based on kind of their natural genetics, metal type and how they can handle fuel. Most people aren’t at that place. And so you kind of have to really look at getting good proteins and fats in there and manage your blood sugar accordingly. And so, the only other thing I wanted to highlight was oh yeah, let’s say let’s say you’re doing a fast like a two day course. free day fast if it’s a punctuated fast, and most people want to faster, they’re keeping their stress down, they’re not going to go work 12 hours a day and deal with stress, because when you’re fasting, you’re not getting nutrients in your body via vegetables, or fruit or protein. So you’re relying on primarily your fat for fuel. And obviously, protein, you’re doing what’s called cellular autophagy, where you’re recycling proteins. And ideally, you’re recycling some of those, you’re getting some of those for fuel, you’re also getting a big bump of adrenaline and cortisol for those couple of days. So you may feel pretty good and pretty alert if your adrenals are strong. And then of course, you’re you know, you’re getting a lot of the fat because you’re tapping into fat, but long term, that’s not good, right? Because we know, any person that’s been on a long term starvation, like diet, you know, you just look at people will were to post concentration camps that were starved, but no one walks out of that healthy, right? It’s impossible. But for a short two to three or four day period, you definitely can. And the key is you have to keep your stress down and under control, maybe do some bone broth, or do some minerals as well to keep your minerals and your electrolytes up. But most people that will still be the equivalent of a CrossFit workout. And if they’re metabolically unflexible, that could break them as well.

Evan Brand: Yeah, well said another question here, I have a friend that lives in mold and is super stressed. How does mold affect the adrenals? Well, it is a huge cause of adrenal issues, mainly because it’s creating this alert response, it’s creating a sympathetic stress, the body’s trying to react to it, hopefully, the body’s reacting to it, meaning that there is some sort of immune response. And maybe there’s some antibodies that come in, maybe there’s some detox pathways that are ramping up. So hopefully your body has a reaction, but it’s a huge adrenal stress. And I would say, even if they’re not living in mold, and you just have mycotoxins in your system, that can be an adrenal stress, or two, I know for me, I had a lot more baseline anxiety when I had just mycotoxins in my system, and I wasn’t being exposed to mold, my wife experienced the same thing. So we were doing adaptogenic herbs to help regulate the adrenals. But once we’ve detox quite a bit using binders, when we’ve done many podcasts on that, my baseline anxiety is back to the way it was before, which was I didn’t have baseline anxiety. So yeah, I can tell you firsthand, it’s a big, big factor.

Dr. Justin Marchegiani: Yeah, I mean, the first thing we have to do, if we have issues with mold is you one, you got to get your environment more stabilized, make sure you’re able to digest and break down foods and get good proteins and good fats in there. Also, on the flip side, right, I’ve talked about, you know, some of the fasting benefits and stories, we have a lot of we have a large group of people out there that are carnivores, like they literally just eat meat all day long. And they do amazing, right, and so like, you have to look at both sides of the camp, because their success stories on both sides of the camp. And so you have to understand why someone may have a success story over here, and not over there, or why someone over here has one but not over there, you have to look at it in a kind of non dogmatic type of, of mindset, right? People kind of have their camp and say, Well, this person over here has to be lying. It’s like, Well, probably not. And, you know, we’ve seen 1000s of patients. So I’ve been able to kind of understand why certain people on the high carb get great success and why people on the extreme low carb, and why somewhere in between tends to be the biggest bang for your buck, right and, and then who are those people that way you can make recommendations and push people to either direction, so they can get better results. Because it’s like you’re either you either have like my allegiance is to getting the patient the best result not to using a tool to get them to the result, I put enough tools in my tool belt so I can be non attached to the tool because I want the result to get happen for the patient. Some people are really, they’re really attached to the tool, and they want this tool to be what gets them the result. And you really have to, as a patient, find doctors that are unattached to the tool, they really just want to get you the result that you’re looking for.

Evan Brand: Yeah, well said and, you know, me being an ectomorph, you would think I wouldn’t do well with just tons of meats and fats. But I do great, really low carb and there is some discussion of mold and fungal infections and candida overgrowth and CBOE and CFO and some of these things, that people will do better. And I definitely had a history of a lot of gut issues. So I think for me, that’s part of the reason I do so well low carb as an ectomorph. But I certainly feel fine on starch and white rice and berries and, and all of that. And I’m kind of lucky, I guess I think it’s a blessing to be able to do both, it’s a blessing for me to have a grass fed steak with just blueberries for breakfast and feel fine all day. But it also be cool to do some rice with some dinner and have no issues with it. 

Dr. Justin Marchegiani: You have enough of a solid foundation with your proteins and your fats and your nutrient density. Where those those a little bit of carbs, it’s not gonna be enough, it’s kind of like you have a fire going you have a good log already in there. If you throw a little bit of kindling extra in the fire, it’s the fire is still gonna be there, right still gonna be strong. And so that’s kind of where you’re at and the more metabolically flexible you get, you know, but in the end, you got to listen to your body, right? We got we got to be we got to be data results driven, not not dogma driven. And if you feel great doing something, and you know your nutrient density is up and you’re in you feel good and you feel energized and you feel flexible and you don’t feel inflamed. That’s really important.

Evan Brand: Here’s what I recommend this podcast is brought to you by Daybook. No, it’s not actually brought to you by Daybook. But Daybook‘s a cool app that I have on my phone. And I love it, because I’ll pull it up real quick. I love it. I wish I could share my screen on my phone somehow. But anyway, I love because I can just scroll through it. So people don’t audio, you’re not going to see this at all. And I apologize. But anyway, it’s cool, because you can look at it. And you can go may 27, may 25, may 23. And you could just scroll through and you could be like, oh, look on May 3, I wrote here that I did a grass fed steak and a big old bowl of white rice, and my blood sugar crashed. So it’s fun to be able to report back. I know there’s a million apps out there. But that’s just one that I like, because I like to be able to hit the plus button, start new notes, do voice to text, whatever I can and then boom, I can look back, and I’ll just be like, oh, here, here’s where I messed up. And so I think people have to track this. You’re mentioning that listening to your body. If you’re busy, you got kids, you got a job, it’s tough to know, oh crap, what day was that, that I did the rice and then I did the grain free this and the gluten free cookie or whatever. If you can track it in the app, you can report back, so picking out but that’s what I like.

Dr. Justin Marchegiani: I like that. Also, just for my autoimmune patients listening I see a lot of patients that have thyroid issues hashimotos other autoimmune issues, blood sugar fluctuations high to low can definitely increase immune activation. I have a couple of studies here. I’ll just kind of give you all the overview just so you could take on what sticks was study right here talking about the effects of hyperglycemia on an inflammatory response. Another one here, the effects of induced hypoglycemia on inflammation and oxidative stress with patients that have type two diabetes that they made diet changes where they restricted calories and gave them Metformin to cause low blood sugar levels. And they saw an increase in immune response, they saw an increase in monocytes, and platelet aggregation, a whole bunch of things right. And so you know, we’re talking about inducing low blood sugar in a in this could get out of a study on this directly. But we could do this with a bad diet with hypoglycemia from a reactive hypoglycemic diet, like someone consuming a Starbucks macchiato with extra pumps of Carmel in there and you create a low blood sugar response. That way, you’re going to activate interleukins cytokines monocytes immune responses that are not going to be helpful and may even flare up your autoimmunity. And so the more you can snake your blood sugar along throughout the day, with good proteins, good fats and the right amount of carbs for you and your activity level versus up and down swings, the better it will be we know the data on on low blood sugar and the immune response is profound and people that have autoimmune issues, you really have to work on that. Yeah, right here. Although the underlying mechanism remains unclear, increase inflammatory cytokines and leukocytosis are reported after hypoglycemia, suggesting a link between hypoglycemia and in formation. And again, this hyperglycemia will be a little bit different than let’s say intermittent fasting, hypoglycemia, but the faster your blood sugar drops, right? The more inflammation, the more your body’s gonna create a hormonal response, that’s not going to be helpful.

Evan Brand: Makes total sense. Here’s a lady grace left the comment for it. She said she used to do one meal a day and two meals a day. And it felt like a badge of honor when I could fast for longer, but I realized it was stressing me out and not optimal for digestion. Probably meaning saying she’s not optimal for digestion. Yeah, it’s just too much too much at one meal.

Dr. Justin Marchegiani: So you know, if you do that, you know, I think you come at it a couple days a week, make sure you’re relatively healthy. Make sure you take some extra HCl or enzymes, make sure you carve out a little more time to eat that meal, so you’re not stressed. Also, just just go and run your food through chronometer. Like, if you’re getting two meals a day, you know, go go carve out what that meal has to look like you’re gonna find it’s about 50% bigger on average. And that’s just a lot more food and a lot more time and you got to make sure you’re not stressed because we all know what happens when you eat a big meal and then you’re stressed you feel even worse you feel totally weighed down, you feel nauseous, then your next meal you don’t even want to eat it because you’re still just upset. So yep, I think we hit today really good. I would just say like understand the connection between cortisol, adrenaline, your immune system, why some people get great results doing different diets and other people right read between the lines be results driven, not dogma tool, modality driven. It’s really important right? Check your biases at the door. Outside of that I hope this podcast resonates with different folks if you want to reach out and you want to get individualized help from Evan, you can reach out to Evan. Dr. J here You’ll see schedule links. We’re happy to work with patients worldwide. You know we are in the trenches rolled with our sleeves rolled up dealing with people every single day so we’re here to help outside of that if you enjoy the content, put your comments below let us know what you liked the best and please share with family and friends that could benefit it really helps propel kind of our life’s mission to help more people every day. Appreciate it. Anything else Evan?

Evan Brand: No that’s it Take good care and yeah leave us a review on your Apple podcast app we’d love it if you’re on Justin health show or if you’re on my show and brain show, give us a review, we’d love to see what stars you think the show deserves. We’ve got hundreds and hundreds of five stars we’d love to add to it that helps us in the rankings so more people can hear us. So thank you so much in advance and take care yourself.


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Collagen Diet: Collagen-Rich Foods for Healthy Joints, and Skin

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I do 20 g of collagen in my coffee every morning. I think it’s amazing. I do my true collagen with some MCT oil and grass-fed butter. I love it. I think it’s excellent for skin, hair, nails, and just for overall prevention of bone loss and cartilage loss. We know the wear and tear that most people experience in their joints throughout the year, especially if they do a lot of long-distance cardio. You really need more building blocks to help prevent and mitigate the wear and tear, so you don’t have knee and joint replacements later in life. Collagen can really help decrease some of that wear and tear.

How do you take collagen?

I like adding collagen in my coffee in the morning because it has a nice little kind of creamer-like effect. It gives that little bit of frothiness which is wonderful. I also do it before bed. Sometimes I’ll do a little bit of collagen (glycine), magnesium, and vitamin C because vitamin C is a really important building block for making collagen. I find magnesium has some very good calming effects as well where there are plugs in the GABA or it’s just a natural beta-blocker as well. It can calm the heart and bring the heart rate down a little bit. I think magnesium does work on some of those GABA pathways as well and, of course, magnesium helps with blood sugar. You’ll get deeper sleep and better REM sleep when you have good magnesium. So, I love combining collagen and magnesium at night.

Where can you get collagen from?

You can get collagen from food via bone broth. Chicken skin is super rich in glycine, roughly 3.3 g for 3-1/2 oz. If you make chicken soup, throw the whole chicken in there. Get a rotisserie chicken from Whole Foods and or get the fattier cuts of the chicken at least with the bone and the skin, so that way you get the best of both worlds if you’re going to do it from a whole food source. Regarding seafood, wild salmon is going to be the best source of glycine.

If you want to learn more about the collagen diet and other good sources of collagen, click this link to schedule a chat with me!

Natural Herbs and Foods to Help Fight Stress

When you’re stressed, what are the important things? Blood sugar stability is really important because most people get on a roller coaster when they get stressed, meaning they’re overly gravitating towards alcohol and towards refined sugar. Their blood sugar goes up and then it crashes down, and then it creates more nervous system stimulation via adrenaline, epinephrine, and cortisol being stimulated to bring the blood sugar back up.

Click here to consult with a functional medicine doctor for guidance on which foods to eat for stress relief.

So, I find just keeping it really simple and really easy with your meals. You may be more nauseous when you’re overly stressed because stress hormone does cause you to feel nauseous. So, this is where you may want to do a soup or a simple smoothie, something really easy where there’s not a lot of digestion but you’re still getting some proteins and fat in there, whether it’s some collagen and some coconut milk or just sipping on some bone broth. Something like that’s going to have some good fat and good protein, and it won’t be hard to digest. So, if you feel nauseous, just still know you should probably be eating but just try to make it something very easy on your tummy.

Then think what are some of the nutrients your nervous system is going to need when you’re more stressed. So, the low hanging fruit, B vitamins. B complex is going to be very essential. Magnesium is going to be excellent. GABA and L-theanine are good things that are going to help you relax and wind down. Valerian root or passionflower, which are all connected to GABA and that inhibitory neurotransmitter that helps you just relax a little bit. It kind of puts the clutching gear and disengages the gearbox, so you can downshift so to speak.

I always go to nutrients first and then I go to my favorite adaptogenic herbs second. So, Ashwagandha is one of my favorites. Rhodiola is excellent and there’s holy basil, which are my favorite very relaxing and tonifying herbs.

If you want to learn more about herbs for stress relief, click this link to schedule a chat with me!

The Top 5 Reasons Why Your Estrogen Levels are High – Men & Women!

Let’s talk about the top 5 reasons why your estrogen levels are high. We’re going to break them down today.


First, let’s look at the 3 major kinds of estrogens: E1 or estrone, E2 or estradiol, and E3 or estriol. In a woman’s regular cycle, it’s usually estradiol we’re talking about. When you start shifting to more menopausal and the ovary stops working, you start getting more estriol. The adrenals help in kick in a lot of DHEA and you make more estriol. Estradiol is more of the growth factor type of estrogen and estriol is a weaker estrogen.

Click here if you need to consult with a functional medicine doctor to learn more about estrogen and your hormones.


  1. PLASTICS. You’ll get it when the plastic is warm like in a microwave or out of a plastic water bottle especially if it’s in the car and the sun is hitting it or it’s outside. That’s why you want a good stainless steel or glass water bottle if you’re going to go outside or leaving it in the sun. The microwave heat and the radiation is going to cause a big release of plastic chemicals there, the xenoestrogens. One of the big ones are the phthalates but also BPA. There are other types of BPAs that are new which are supposedly safe but there are still estrogen-like compounds there as well. These plastics can affect women and men as well. Men are actually going to be more affected by them because men aren’t used to having estrogen in their environment and getting a whole bunch is going to be a problem.
  2. PESTICIDES. These tend to have an estrogenic quality to them and if you’re eating foods that are not organic, you’re definitely going to be getting organochlorines and various pesticides in your environment.
  3. PHYTOESTROGENS. These are found in soy. For example, I had a vegan-vegetarian patient. We ran a Dutch sex hormone panel on her and her estradiol was through the roof and really high. Phytoestrogens can be a big one, so soy may be a problem. With vegan-vegetarian, there’s a lot of phony protein consumption like fake meat kind of stuff such as the Beyond burger where there are a lot of soy and estrogen-like compounds in there. There are also hormones in meat. You have to make sure you get antibiotic-free, hormone-free, and ideally organic and pasture-fed or if you’re on the Whole Foods scale, step 4 or step 5 is ideal. Step 2 is at least pretty good. Organic means no pesticides, no hormones, and also the food they’re eating has no pesticides or hormones, too.
  4. HIGH LEVELS OF INSULIN. Too much carbs drive high levels of insulin because insulin responds to a high level of blood sugar. The blood sugars in your bloodstream go up and your pancreas comes in. The beta cells make a bunch of insulin to bring it down and bring it into the cellar and converted to fat. So, high levels of insulin upregulate an enzyme in men called aromatase that converts testosterone, the male hormones, to estrogen which becomes a problem. Now, in women, a similar thing happens but it’s the exact opposite or the big switch. Their estrogen is converted to testosterone. So, women can actually get more androgen-like issues which results in weight gain, acne, hair growth, and sometimes you can see some libido enhancements on that. So, that’s the difference between men and women.
  5. POOR GUT HEALTH. In the gut, we make healthy good bacteria in our gut that help us absorb a lot of nutrients. A good healthy gut function helps us break down protein for good HDL levels and good enzyme levels. We need these to break down protein into amino acids which are really important for helping us to detoxify. So, detoxification helps us to excrete estrogens that we’re getting exposed to in our environments such as the pesticides, plastic, or something that you don’t even know you’re getting exposed to. Good healthy detoxification will help your body eliminate that, so that’s a good backup plan.Also, if we have a lot of dysbiosis, SIBO and bacterial overgrowth, we can make a lot of what’s called beta-glucuronidase. This is an enzyme that’s made by bad bacteria and it makes it harder to detoxify estrogen. The beta-glucuronidase takes conjugated estrogens and binds it to a protein that helps us excrete it out the body. It takes that protein and it pulls it apart. It takes the handcuffs off that protein, so that allows that estrogen that’s been deconjugated to go back into the body in the general circulation. So, if we have gut issues, that could be a major concern.


We need things like cysteine, glycine, glutamine, sulfur amino acids, and things that help us methylate like B12, B6, and folate. So, these nutrients we have to get them in our diet via a good diet. We need to be able to break down and absorb those nutrients, so we need good digestion to get those things in there.

So, in general, we’ve got to make sure we have a good gut bacteria balance. Even fungal overgrowth can cause problems and H. pylori that can lower stomach acid and make it harder to break down nutrition on one side and then it can create this bacterial overgrowth enzyme that makes it hard to detoxify estrogen. These are really important components. If you have any issues with estrogen, you’ve got to look there.

Now, we may want to do things to help detoxify like make lifestyle changes, food changes, pesticide changes, make the changes in regards to plastics, and make in in regards to your diet, your glycemic load, and your gut. That’s a good first step to get to the bottom. There are also different things we may do to help upregulate detoxification to help get that estrogen. It may be activated charcoal or various soluble fibers. It could be things like bentonite clay. We could use things like DIM or Calcium D-Glucarate or glutathione, sulfur amino acids, and vitamin C. They’re all helpful in different situations. We would recommend them based on what’s happening but at least make the diet and lifestyle changes out of the gates.

If you want to find out the root cause of what’s happening, click this link where you can schedule a chat with me!

Top 5 Warning Signs of Hormonal Imbalance

Let’s talk about hormones. I’m going to dive into a couple of clinical pearls that I see in my practice from working with hundreds of female patients and male patients which have a major effect on modulating and supporting hormonal balance.

Click here for a consultation with a functional medicine doctor if you want to learn more about hormonal imbalance.


These are my top 5 hormonal balancing strategies:


  1. One of the first things in regards to hormones that’s very important, and this may be common sense but I try to give a lot of knowledge guided by experience, is nutritional building blocks for your hormones. Healthy cholesterol from animal products are very essential. Fat soluble vitamins like A, D, K are very important. Lots of good protein are also very important. We have steroid-based hormones that are going to be more cholesterol-based and we have peptide-based hormones that will also be protein-based. So, a lot of these protein, fat-soluble vitamins, and cholesterol especially healthy animal cholesterol are very helpful for hormonal building blocks. If you have a vegan-vegetarian diet or if it’s very nutritionally poor or there’s a lot of processed food, that may set you up with a deficit out of the gates for just hormonal issues. Remember: Make sure the food is nutritionally dense, anti-inflammatory, and low in toxins. That’s vital.

  1. Now, if you’re having a lot of good nutrition in there, the next thing is we have to make sure we’re able to digest it and break it down. So, if we have a lot of chronic acid reflux, poor digestion, constipation, or bloating, we know we’re not quite breaking down our food and our nutritional building blocks. That could tell us that we may have hormonal issues because we’re not breaking that down. Therefore, those nutrients can’t get into our body or get in our bloodstream and be taken throughout the body to be used as building blocks. So, if we have a bottleneck in the nutritional side, that could be a big factor.

  1. Stress, whether it’s emotional or chemical stress. If we’re eating foods that are inflammatory or we’re nutritionally deficient and we have a lot of emotional stress, what tends to happen is our hormones kind of go on two sides. We have an anabolic side which are the growth hormones — testosterone, estrogen, and progesterone — that kind of help deal with growing. Then we have anti-inflammatory hormones which would be cortisol and are catabolic. I always put progesterone in that category because progesterone can be used to make more cortisol. So, we have our anti-inflammatory and then our anabolic. In some, they kind of cross over. Insulin, growth hormones, and testosterone are anabolic. The more inflamed we get, we could have high amounts of testosterone because of PCOS and because of inflammation. So, some of these hormones kind of interact and cross over. With men for instance, the more inflamed men get and the more stressed they get, that can actually cause an upregulation of aromatase and could increase their estrogen. So, see how these things kind of cross react. Your hormones are going to be either pro-building or anti-inflammatory to reduce stress. So, for chronically and stressed out state, cortisol is going to rip up your protein and kind of decrease your muscle mass. As a woman, you’ll see your progesterone level start to drop and that will start putting you into an estrogen-dominant state because if we normally got 20 to 25 times estrogen than progesterone, that ratio starts to drop. Even if you still have more progesterone than estrogen, that ratios is going to throw you off and that can create breast tenderness, cramping, mood issues, excessive bleeding/menorrhagia, infertility, a lot of mood issues, back pain, and fluid retention. All those are possible situations.

  1. Xenoestrogens from the environment and foreign estrogens. They can come from plastic components, pesticides, herbicides or rodenticides, mold toxins, and heavy metals. They are going to disrupt our hormones. The easiest thing is eat organic, avoid plastics, and avoid a lot of the chemicals in the water because a lot of times you can get pesticide runoff or hormone runoff in the water. So, clean water and clean food, and then make sure it’s organic avoid the plastics as well. That’s a big, big thing. Plastics are probably okay if they are in a refrigerator or in a cold environment but ideally if you’re heating stuff up or it’s going to get exposed to light, you want some kind of a Pyrex or a glass container. It’s much better and really important.

  1. Last but not the least would be just making sure our detoxification pathways are running well. So, if we have good hormonal balance but we can’t detoxify it, then a lot of times we can reabsorb it. So, if we don’t have good sulfur, good glutathione precursors, good B vitamins, good methylation, N-acetylation and glucuronidation, we may have a hard time eliminating. Hence, we are re-absorbing a lot of our hormones. So, being able to break down your proteins, break down your amino acid and your B vitamins is going to help with your body’s ability to eliminate a lot of these toxins.


Blood sugar, digestion, stress, xenoestrogens, and toxicity are really big. Those are the big 5 across the board. Try to apply at least one of these things.

If you’re struggling with hormonal issues and you want to dive in deeper, feel free to schedule a consult with myself.

Natural Solutions to Address POTS (Postural Orthostatic Tachycardia Syndrome) | Podcast #329

POTS is a known blood circulation problem indicated by two elements: a specific group of symptoms that constantly happen when standing. A heart rate suddenly increases from horizontal to standing (or as tested on a tilt table) of at least 30 bpm in adults, or at least 40 bpm in adolescents, measured during the first 10 minutes of standing.

Management for POTS should be specific to each individual since the symptoms and underlying conditions may vary. Most patients can control the situation with food templates, exercise, and medications. In this podcast, Dr. J and Evan emphasize the importance of the quality of food that we eat and seek medical attention, and undergo tests that will find the disease’s root cause for better understanding and achieve a healthier body.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

1:15      What is POTS

10:56  Adaptogenic Herbs

15:15   Addressing POTS

24:43  Detox and Sauna

27:14  Other Natural and Organic Tips

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Dr. Justin Marchegiani: And we are live. It’s got the J in the house here with Evan Brand really excited to have a excellent podcast on the topic of POTS, postural orthostatic tachycardia syndrome, which is has to do with blood pressure and dizziness. And there’s a strong connection with POTS and the adrenals we’re really excited to dive into that today, Evan, how are we doing today man?

Evan Brand: Doing really well. I feel like I started every story or every podcast by like complaining a little bit, but that’s okay. Because we learn from our personal struggles. And that’s what makes us better practitioner. So I was telling you before we hit record that when I had the, you know what virus, I had a lot of POTS types symptoms, I was really dizzy, I was really faint. I was having some lower blood pressure. I was having some heart palpitations, I was having some mental confusion just fell out of it. And so dealing with it personally, I definitely tried a lot of different things. So you and I are going to try to go into it. You and I were talking about the adrenal piece. So why don’t you just start telling us about that? What do you think the connection is? You think it’s a more of a low cortisol deal? A high cortisol? Do you think it’s just adrenal weakness? The whole HPA axis is functioning as a whole, or do you think there’s any specific part of adrenal problems that’s causing this?

Dr. Justin Marchegiani: Great, great, great question. So first off, you know, what is POTS? Right? So essentially, there’s like dysautonomia happening, right? The autonomic nervous system that controls heart rate, and blood pressure, sweating, all of these different things, the symptoms are over exaggerated now. So when you change body positions, you may get very dizzy lightheaded, right, your heart rate may be really up, energy fatigue, maybe up, right, conventional medicine, they’re going to use a tilt table test to kind of simulate that change of body position, and they’re going to test your heart, they’re going to test your blood pressure, okay? Now the typical response you want in, in natural medicine, there’s a test called the raglans test, which looks at blood pressure and correlates it to adrenal dysfunction. And so the raglans tests, basically test your blood pressure when you’re sitting or laying down, and then you stand up or change body position, you want your blood pressure, actually to go up about five to 10 points, okay? People that tend to be more on the pot side, where they have a lot of those symptoms on changing their body position, they tend to actually have a drop in blood pressure. And that’s important, because when you change body positions, now, if you’re like more horizontal, well, guess what, it’s easier for your blood to flow to your brain, right? Because blood flows downhill. And if it’s level than that, that works too, right? soon as you get up. Now, you really have to pump blood uphill, if you will, to get to your brain. And so if you have a drop in blood pressure, you’re not going to have enough pressure to perfuse that blood nutrition and oxygen to the brain. So that’s a big thing. So you may have symptoms in regards to your heart, in regards to dizziness, right? body awareness, all those different things because you don’t have adequate blood pressure. And so that’s a common sign with adrenal issues. And it’s possible to be on the POTS spectrum, where you have that change in body position, you have that change in lower blood pressure, but you know, your conventional medical doctor may not be able to diagnose you with POTS because it’s not severe enough. So like anything, there’s a there’s a continuum on a diagnosis, right? disease, allopathic kind of criteria is here. And then we have optimal health here. And usually there’s a spectrum of where you may sit where you’re kind of in no man’s land. And so most of our POTS patients, right who are on that pot spectrum where there’s blood pressure issues, on the lower side or the change in body position causes lots of disturbances cognitively cognitive wise heart issues, whether it’s faster or or beating through the chest kind of things, or abnormal rhythm. All of these things are connected to adrenals. And adrenal is are of course connected to blood sugar. They’re connected to your minerals, your sodium, your chloride, your magnesium, your potassium, blood sugar, cortisol glucocorticosteroids. And then of course, your adrenals eventually have a connection with your sex hormones. So you can see chronically lower dapa back can create other lower or more sex hormone imbalances that can create more issues, whether it’s PMS, low progesterone, more anxiety, more depression, poor sleep. So you can see how an adrenal issue can easily spin into a sex hormone issue, partly because the adrenals really are one of the backup generators for the sex hormones. And so especially if you’re a female, you’re going to rely on those adrenals to pump out dapa sulfate. And that’s going to be a major building blocks. So as you transition into menopause, you’re going to rely more on those adrenal. So as you hit your 40s, it’s common as those ovaries aren’t supporting the hormonal output like they used to that you may start to lean more on the adrenals. And more of those POTS type of symptoms may show up.

Evan Brand: Yeah, well said, well, you pointed out something really interesting. I never thought about it like this, but you and I clinically we kind of operate in the no man’s land, meaning that people may have not been extreme enough, as you mentioned, to get the clinical diagnosis. I mean, the same thing happens with celiac, right? They’ll say that you have to have some In crazy, like 95% tissue destruction in the intestines to be considered celiac, but if you’re like 94%, they say you’re not celiac, go eat some bread, it’s fine. So it’s very interesting point you made. And we’ve actually had clients report this to where they’ll say that their pulse rate or their heartbeat only increased by maybe 20, or 25 beats upon standing. And they were told clinically, it had to be 30 beats. So if you’re 28 beats, you’re still not pods, if you’re 30 beats, increase your POTS. And so that’s the problem is there’s this huge in between area where people have these symptoms, but then they go to their doctor, and they’re basically going to get told that everything is fine. And there’s really nothing we can do for you or possibly what they’ll do. If it was moderate enough, but maybe not clinically diagnosed on paper, maybe they do a beta blocker, because they say, Okay, I understand you’re standing up, you’re having heart palpitations, you’re having chest pain, let’s go ahead and do this meta pro law or other beta blocker to try to calm the symptoms, but then you never actually fixed the adrenals you never support the hormones, you never fixed the minerals. And all of that still goes unaddressed. And then of course, you get the side effects of the drug, and then you create more problems. So you see how this could be a really big slippery slope. And then also one thing I want to mention too, because I experienced it personally was you mentioned like the the dizziness and that kind of stuff, but also just mental fog. I mean, if you don’t have enough nutrients, enough blood flow, you just feel kind of spacey. So if you’re having trouble with focus, a lot of times you and I are looking on like an organic acids test to try to look at dopamine or other neurotransmitter problems. But this whole dysautonomia POTS thing could also create brain fog. So that’s just something else that we’re going to be looking for and trying to address.

Dr. Justin Marchegiani: Yeah, so typically with POTS is you’re gonna have a combination of a drop in blood pressure, right? So conventional medicine diagnosis is looking at a 20 millimeter drop in mercury on the blood pressure cuff on the systolic, that’s the top number, and then about a 10 or more on the bottom number. So if it’s normally 120 over 80, you know, you got to be at, you know, below 100 over 70, if you will, okay, and that’s in the first couple of minutes of that change in body position. And then typically, as the blood pressure drops, now you’re not able to move as much blood. And so what has to happen is your heart rate has to increase to compensate for the lack of pressure. And so as the heart rate increases, that’s where you start to see the increase in heart rate, that’s where the, the postural orthostatic that’s the change in body position, tachycardia, that means faster heart rate. And so that’s where you start to feel your heart beating out of its chest. Okay, and so then you have the drop in blood pressure on one side, and the increase in heart rate on the other side. So the first thing we look at, from a functional medicine perspective, where are we in? Where are we at with hydration? Okay, are we getting enough water and hydration in? Number two? Is that full spectrum mineral water? Are we getting a really good mineral water? Are we getting? are we adding additional minerals to it? And then number three, where are we at with diuretics, coffee, tea, things that have caffeine because coffee or tea number one will increase adrenaline, right? And adrenaline is part of this whole POTS cascade, so increased adrenalin, increased, cortisol can always increase the heart rates. But it also acts more as a diuretic where you pee more water out, that drops your blood pressure. And then when you drop the water, you drop the minerals and your heart needs sodium and chloride and magnesium and your minerals to function. Remember, magnesium is a natural beta blocker. And so if we can get the minerals in that brings the blood pressure up because water follows minerals. And if we can get minerals in that relax the heart because magnesium is a natural beta blocker, right. And so that can really help start to relax the heart, but you got to fix the underlying issue. And so you got to really get and that’s just a couple of lifestyle, diet strategies out of the gates, we’ll talk more specifically. But anyone that has POTS or POTS symptoms, we have to really look at the adrenals. And you may not necessarily have an Addison’s issue where your cortisol is pathologically low, right, or Cushing’s where it’s pathologically high, it may be some kind of an imbalance in between. That’s why we use the word adrenal dysfunction because some people are high in the morning, low at night, and vice versa. So it may not be high throughout the day or low throughout the day, you could be somewhere in between. And so we really got to look at these things and test it and quantify and see exactly where you’re at.

Evan Brand: Yeah, great points. And on the testing, you made another great point, too, which is that if you do work with conventional medicine, they may say that your problem is not bad enough to be pathological. So we’ve had clients that will do just a morning cortisol sample via blood, and their doctor says, Well, your cortisol levels are fine. And it’s like, okay, yeah, you took an ATM blood sample. And that’s it. That’s just not enough tensional data, you have no, maybe you have a better analogy, but my analogy is you’re you’re touching the sidewalk to estimate the forecast. You have no idea what’s going to happen throughout the rest of the day with that rhythm. So if you’re having your POTS episode at 2, 3pm, you’re crashing, well, what’s going on from a cortisol perspective at that point with that 8am blood sample and that’s it. You don’t have a clue. Let me let me mention a couple things too. So I know that a lot of people with mold, just looking at Dr. Shoemaker and his big list of symptoms, POTS is sort of thrown in to some of these symptoms for mold exposure, and then also lyme. So when you’re trying to find root causes adrenals could be a factor, but there could be another layer deeper. So if you’ve had any kind of take issues, coinfection issues that could be a problem. And so, I know Stephen Buner, I talk about him a lot. He’s a really great herbalist who’s written a lot of books, he discusses using Hawthorne. And so I’ve experimented with some heart formulas myself, like mixing CO, q, 10, and Hawthorne. And I’ve had really good success with it. And so I think those are two, two good herbs that you know, two good nutrients that could help. And then also gingko could be helpful too, because gingko is going to help with blood flow and microcirculation. We use it a lot for brain problems. But I do believe that it can be helpful for POTS. And then let’s talk about the adaptogenic herbs. So I guess it really depends on what you’re looking like. But in general adaptogens are going to help modify you either way. So I would say something like rhodiola, or maybe a good ginseng, like an eleuthero is going to be probably the top top choice on adaptogens. What would you say? Oh, what about licorice? Should we talk about that?

Dr. Justin Marchegiani: Yeah, so a lot of these herbs out of the gates, you know, they’re nice, because they’re going to help with blood flow. A lot of these herbs like gingko, or Hawthorn, they tend to be used more on the high blood pressure side, right. And so they may help with blood flow. But remember, I think with POTS, there’s definitely more of a blood, low blood pressure kind of kind of thing. So we have to kind of, you know, make sure we support all of the other underlying issues. Because, you know, a lot of times, if we’re not getting to the root, then we may not get lasting results. Plus a lot of times the medications that are used, what are the big medications that are used out of the gates, is it just beta blockers out of the gates, I know they do some things like floor enough, which can be helpful, which is basically a pharmaceutical version of aldosterone, which helps to hold on to sodium, which helps increase blood pressure. You kind of alluded just a minute ago, licorice does help mimic that. And so we can use things like licorice, that non diglycerides meaning not licorice, that’s diglycerides de glycerides. licorice loses that aldosterone stimulating effect, and it’s more for gut healing. But if we’re using licorice that has not been de glycerides, non dgl, licorice that can have very powerful effects on low aldosterone levels, and it can help hold on the minerals better. So for adding more minerals in there, that’s helpful. conventional medicine typically only talks about it from a perspective of sodium and sodium chloride, they kind of forget about the magnesium and the potassium part of it. So magnesium and potassium are also very important. Also, they’re using a lot of beta blockers, right? So beta blockers, guess what they reduce the heart rate, but they also can reduce the blood pressure. And they have effects of creating nutritional deficiencies. And it can it can lead you can lose some of those same minerals, magnesium, etc, that are also very helpful for the heart in general. So the problem with a lot of the medications, they can actually make some of the problems worse in the long run, because they’re not fixing the underlying issue.

Evan Brand: Yeah, well said, here’s here’s a couple other drugs, you’re asking what drugs, here’s a list of them. There’s one called Ivabradine. It’s a drug that acts on the heart to slow the heart rate, but it slows the heart with without affecting blood pressure. And then there’s another one here, underneath, it’s hard to even pronounce it Pyridostigmine, the brand name Mestinon, this is a drug that prevents the breakdown of acetylcholine. So that’s pretty interesting. It’s like an acetylcholine esterase inhibitor, I guess. 

Dr. Justin Marchegiani: Hmm, interesting. 

Evan Brand: It says they use it for. Let’s see here. Myasthenia Gravis. 

Dr. Justin Marchegiani: That’s an autoimmune condition that affects the postsynaptic neuron where acetylcholine plugs in. 

Evan Brand: So they’re using that drug for POTS also, I guess it’s kind of an off label deal. And then SSRIs for some reason, it says here that, you know, people I guess they’re saying practitioners suspect that the fainting spells may be related to serotonin or some other neurotransmitter so they also use SSRIs. But once again, none of this is root cause and as you mentioned, the conventional like Web MD stuff is all about sodium, sodium, sodium, like you should just be frickin eating spoonfuls of like iodized salt all day, which is just ridiculous.

Dr. Justin Marchegiani: And there’s different kinds of salt right? And there’s some salts that we like that like real salt or Redmond Real Salt or Celtic salt or Himalayan that are gonna have sodium and chloride but a bunch of other minerals as well, which is great. The problem a lot of the medications for instance, beta blockers are notorious for depleting CoQ 10. And we need coq 10 for healthy heart function. So problem with a lot of these medications is you’re kind of robbing. You’re paying your credit card debt from last month with a new credit card you open this month. And so you can only play hot potato like that for so long before that bill becomes due.

Evan Brand: We made the point about the potassium to I think we talked about that for a minute because you’re saying even if we do bring in some of the Celtic or the mineral salts You may get some trace amounts, right? But you’re not going to get a significant amount. So you’re thinking possibly supplementing, like we have. I know you and I work with a couple electrolyte formulas where there’s some potassium added in there. So something like that would be better than just straight salt.

Dr. Justin Marchegiani: Yeah, so how I look at it with patients is first thing first is drink enough water. Make sure that water is clean, filtered, no crap, not tap water, number one. Number two, avoid the diuretics. Right. avoid caffeine. avoid alcohol, avoid teas, right. So that way you’re not peeing out extra water and minerals. add extra minerals to your water. So good. Redmond’s real salts Celtic sea salt, half a teaspoon teaspoon twice a day is great salt your food very liberally hydrate you know, 20 ounces or so before each meal 1015 minutes before drink in between meals. It’s great. If you’re drinking a really clean reverse osmosis water which is fine. Just make sure you add extra minerals back to it. definitely avoid any distilled water. And then if you want to drink like a really good clean mineral water throughout the day, my favorite here in Texas Topachico’s wonderful, right? It’s the Pellegrino of the South Pellegrino is also wonderful good mineral sulfate drill Steiner, Evian, Fiji, Fiji has got a lot of silica in there really excellent out of the gates love those. I would say also, you may need to have more potassium and magnesium than what you’re getting in mineral water and in the salt, because you need about 4700 milligrams per day. So I recommend everyone, head over to, put the link below, run your macros run a typical day through there, right put your age, your height, your weight, your activity level, and you’re gonna find you need about 4700 milligrams per day. And that’s the [inaudible] daily recommended intake, most people are only getting two to three grams 2000 to 3000 milligrams, and you’re probably have a deficit. And then you also have to factor in when you’re stressed. And when your adrenals have issues, you may need a couple extra grams on top of that, because you’re losing extra minerals. So you got to factor that in. So take a look, see where you’re at, see how low you’re at. And out of the gates, you know, you want to supplement additional potassium, whatever that recommended intake is if you’re at 2700 milligrams, you want an extra 2000 milligrams to meet the needs. And then from there, you really want to work with a functional medicine practitioner because if you go too high in potassium without enough sodium to support it, you can actually you can actually lower sodium by doing too much potassium so you got to keep that sodium potassium in check. Now if you’re doing Redmond’s Real Salt, like I mentioned, along with the potassium, you’re probably okay. But if you have any POTS issues at all, you really want to be working with a functional medicine doctor like us, you want to be looking at cortisol, like Evan said earlier, a blood test is only going to look at your serum cortisol, your protein, it’s not going to look at any of your free cortisol, it’s not going to look at it throughout the day. It’s not going to add it up throughout the day. And then we also run organic acids that look at the catecholamines the adrenaline, the epinephrine again, adrenaline, catecholamines, and epinephrine. It’s all the same thing, right? Medicine uses these words to confuse the heck out of you, adrenaline, catecholamine, nor epinephrine, all the same thing, okay. And so we have to test those and we use organic acids, we’ll run tests for Vanilmandelate and Homovanillate, which gives us a window into your adrenaline precursor. So if we’re burning up adrenaline, we gotta support the amino acids, we got to calm down the adrenals to really help the body. So we’re not creating all this extra stress because that stress causes you to dump minerals. And so if you’re dumping minerals, we have to replace what you typically need. Plus a little bit on top of that, plus, we got to fix and calm down the whole nervous system, right? That autonomic nervous system, that’s the automatic nervous system that controls heart rate, beat, these are things you don’t typically think about. You don’t think about beating your heart, it happens automatically. So we got to help calm that down.

Evan Brand: Yeah, so even some of the lifestyle strategies can get involved too, right? I mean, you could take all the adaptogens. But if you’re just a type A personality or a go getter, you’re not resting, you’re not taking breaks. So I would argue, some music, I would argue meditation, guided meditation, maybe a float tank, deep tissue massage, may be myofascial relief, anything that you could do to try to basically downshift your nervous system. Because yes, you mentioned something several times, which I think really kind of just ding ding ding hit the bell for many people, which is the the variable of stress. And people that are more stressed are going to have this problem more, you’re likely not just going to be sitting on an island, you know, getting, you know, spoon fed pineapple and you feel POTS. Now, this is going to be people that are really under the gun. They’re in the middle of a lot of transition there. Maybe Who knows, maybe they lost their job. Maybe they had a viral issue that really took them down like you had a post viral type POTS Come on. So stress, I think is the big variable and that’s where the adaptogens come in and help the nervous system self regulate. However, I’ve done adaptogens for years and I can still be stressed so I still have to focus During the lifestyle stuff, take the kids for a bike ride, go ride the skateboard, go for a walk, go for a hike, just sit out in the sun and listen to music. So you got to come in with the lifestyle stuff too. You can’t just go take the magic pill and you know, eat the salt and be cured. I think at a certain point, you need to come in and evaluate your lifestyle and figure out do I have toxic people I need to cut out am I working too many hours? Am I able to delegate some of the work I’m a you know, financial advisor and I’m too stressed I’m working 60 hours a week, can you delegate Can you reduce the workload reduce the stress, because in a vacuum, the stuff that we’re talking about, it won’t get you fully out of the woods with this, I do think you have to do a good life evaluation.

Dr. Justin Marchegiani: 100% got to look at all of it right. And that’s super important. Now, in general with with a lot of things we may want to get, you know, a couple extra, you know, grams of good quality sea salt. So you can start with you know, an extra gram, the 10 grams of high quality sea salt, I typically recommend starting with a half a teaspoon to a teaspoon, two times a day, put it in your water, shoot it down. You can also salt your food very liberally, you know to taste throughout the day. You can also add a little pinch in your water just enough so you can’t taste it, you shouldn’t be able to taste them. You can also drink a good quality quality mineral water right mentioned a couple of these brands. And then you can also work on doing all the right things to reduce stress. So I already mentioned a couple things out of the gates. Blood Sugar is a big thing, the more your blood sugar goes up and down on a roller coaster ride your surging adrenaline and cortisol when your blood sugar goes hypo when it starts to go low. And when you start surging adrenaline, it’s going to create more mineral depletion, because you’re going to pee it out, right? So we The more you can kind of come down that blood sugar and make it more stable part of that by being more fat burner right? healthy proteins, healthy fats and dialing in the carbs, less refined, refined grains, keeping it more to vegetables. And low sugar fruit in those kinds of things play a big, big role in keeping the blood sugar rollercoaster smoothed out. The less blood sugar roller coaster, the less adrenaline the less dumping of minerals does play a huge role across the board.Evan Brand: And this is a new problem. By the way, the blood sugar issue that you’re mentioning this is in terms of modern history, right? Because if you look at like a hunter gatherer, for example, maybe they’re gonna find a beehive and get some fresh honey every once in a while. But never in human history. Have we had access to the processed carbs, the fructose, the processed sugar, these major nations have processed grains, yeah, flowers, any of the stuff that is screwing up our blood sugar. These are all relatively new problems for humankind. So if someone’s sitting back and they’re listening, like God, why is it so complicated to be a healthy human? Well, because we’ve screwed it up with the diet, the lifestyle, the sedentary, the stress, the the schedules, the work hours, I mean, modern life has contributed to this problem. So, you know, I know it’s a little frustrating. And thank God, why is everything complicated with health? Well, because the diet is a big part of it. And I certainly know that when I had blood sugar issues, I had a lot more unstable blood pressure, too. So there is definitely a big connection there. The good news is once you get your diet dialed in, and you are a fat burner, you’re going to feel so much better, you’re going to feel so much more stable.

Dr. Justin Marchegiani: And I remember early on when I was looking at your diet law, we were chatting, I think you were having some of these POTS issues with a lot of the heart racing, right. And I remember looking at your diet and there was like an eight hour gap. In the day where you weren’t eating, I think you were trying to do a little bit more intermittent intermittent fasting, things like that. I’m like, wow, you know, you’re not going to be able to do those things because the fasting is too much of a stress on your body, your your physiology is not strong enough to be able to adapt to that stress. And so if you are doing a lot of intermittent fasting, you really got to be careful of that, you know, so kind of my checklist out of the gates is definitely be more of a fat burner. Avoid the refined flours, grains, high blood sugar types of foods that add in the extra minerals, half a teaspoon, teaspoon high quality, sea salt per day, work with a functional medicine doctor, get your magnesium, your potassium dialed in half your body weight in ounces of water. Clean, filtered water is excellent good quality, reputable brand mineral water during the day. All of these things are vitally, vitally important. Good breathing, good movement, don’t over exercise where you’re sweating too much. You know, make sure you’re doing all the right things and get your adrenals tested, get your organic acids tested to look at your adrenalin as well. I mean, we can always dive in deeper. If you have a lot of gut issues and absorption there. There always could be a bottleneck with the gut as well. It’s always possible, but those are kind of your first steps out of the gates, Alaska with the low hanging fruit, start with low hanging fruit, and then work on finding a good functional medicine support practitioner to get in your corner.

Evan Brand: I wanted to bring this up before you wrapped it up. So last thing, detox and sauna. So I do notice that some clients and me included if we go too high, we do too much. We do too frequent with sauna and or detox support, especially binders, we can run into some trouble. So just like you mentioned On the exercise not doing too much. Same thing with sauna I think you got to be careful with it if you’re already adrenally depleted, if you’re glutathione deficient if your detox pathways are not working, you can overdo it quick. So I would say the average person could hopefully handle twice a week, maybe 135 to 140 degrees for about 20 minutes but if you start to feel woozy, you feel faint, you feel like you’re gonna pass out in the sauna just get out, you’re probably dehydrated, your mineral are off your adrenals are too weak, so don’t push it, don’t push it. And then on the binder piece, work with your practitioner, but in general, sometimes less is more on the binders. I remember when I was doing like eight charcoal per day, I started to feel pretty woozy and it could have been like a detox reaction, but I think it may have been some mineral stuff too. So I was doing some fulvic acids and some salts to try to help balance it, but I still overdid it with binders. So those are just two other notes I wanted to share.

Dr. Justin Marchegiani: Exactly. So if you’re going to do a sauna, make sure if you already have kind of POTS symptoms, one don’t do it right after exercise, probably too much stress. Okay, do a sauna session by itself. Number two, take an electrolyte support a balanced electrolyte support product before you go in and have a good mineral water while you’re there sweating. So then any water that comes out, you’re replacing it as it comes in with mineral so supplement before and then good mineral water during and that should be and then try to keep it under 20 minutes and make sure you’re not feeling any bit woozy or any bit worse in regards to your symptoms while you’re in there. I think that’s a good kind of general way of of hitting.

Evan Brand: Alright, here’s my shameless plug. And then we can wrap up My Hydration Essentials is an electrolyte formula that I drink, I just do a scoop of it. I mix it with water and drink one scoop a day. And it does have some ribose it does have potassium, some taurine, some of the other nutrients outside of just your sodium. And I also drink that in the sauna and I give it to my kids. And I like to actually mix it with beet powder. And we use just an organic beet powder. And I add it to the electrolytes because it really increases nitric oxide. So my hands, my feet, everything gets warmer, circulations better and I sweat, like 25% more sweat in the sauna, if I mix the electrolytes with the beet powder and drink that. So that’s called hydration essentials.

Dr. Justin Marchegiani: And that’s great. And other natural thing that you can do on top of that celery juice is wonderful. You get about one gram of potassium in a cup of celery juice. So celery juice is excellent. Very good. It’s kind of your it’s Mother Nature’s natural Gatorade, right problem with Gatorade ton of sugar, a ton of high fructose ton of dyes. So it’s basically crap. You know, Mother Nature’s gatorades coconut water. But the problem with coconut water is a lot of sugar in it. So you really only want to do a post workout. So the best type of natural low sugar gatorades in the me celery juice, that’s a great option for you a lot of good minerals, a lot of good potassium. And if you do any green juices really avoid any carrot and or any fruit in there because when just juice it, the sugar concentrates really high. And that can create this reactive hypoglycemic drop blood sugar was a fast comes down hard. And this is kind of what feeds into the all the pot stuff. Right, it creates more cortisol aberrations and more adrenaline, noradrenaline stimulation, so just be careful that really good we’ll put links to the some of the products that Evan mentioned and some of the things that I mentioned as well. Anything else you want to highlight, Evan?

Evan Brand: Great call on the carrots. You know, when you think of eating a carrot, like in a beef stew, you don’t think of it as being necessarily sugar. But I have had some clients do what you’re describing, which is they’ll get into the green juices with the carrots and will track their blood sugar. Man, that stuff screws up their blood sugar almost as much as a soda does.

Dr. Justin Marchegiani: Yeah, if you’re gonna have a carrot, eat it whole. Once you juice it, it becomes a problem. Now if you’re doing like, if you’re just using like one carrot, and you’re relatively healthy, probably not a big deal. But if you have blood sugar issues, I stay away from any carrots if you’re gonna have a carrot habit and your salad eat it raw. I think that’s a good way to do it. Still nutrient dense. But yeah, you gotta you don’t want to throw too much blood sugar on that blood sugar rollercoaster. And beets too.

Evan Brand: Sorry. Well, last thing. So I talked about the beets. So the one that we use and carry is a non hybridized beet powder because apparently just like with strawberries, and pretty much every other fruit in the in the modern world, everything’s hybridized now to be bigger, brighter, sweeter. So most beets are hybridized even if they’re non GMO, they’re hybridized and so they’re gonna cause a big blood sugar problem. I have some clients that are just way too blood sugar unstable to handle beets but if it’s a non hybridized version, it is a little bit more well tolerated. So just keep that in mind if you feel kind of woozy. If you do the beet powder thing I’m talking about you feel weird. It could be messing with your blood sugar, you could always test it.

Dr. Justin Marchegiani: Excellent really good. Hey, if you guys are enjoying today’s content and how you support us feel free click down below look at some of our links. Sign up for our newsletter. If the information that we’re talking about resonates Feel free to schedule a call with with Evan or myself we have colleagues and support teams ready to help you out if you want to dive in deeper. We’re here to help you take control your health. 99% of people may not take that step. Use the information. Take Control your health, you’re ready for that next step we are here for you. Share this content with friends or family. Put your comments down below. I want to know what your experiences are with POTS or any of these POTS like symptoms. We’re here to help and appreciate you guys all engaging. Have a phenomenal day.

Evan Brand: Take care now. 

Dr. Justin Marchegiani: Take care y’all. Bye now.


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Role of Functional Medicine in Mental Health | Podcast #326

As an adult, maybe you’re struggling with some of these symptoms yourself, things like anxiety, perhaps depression or mood issues, those types of things. Or many of you have kids with these types of mental health symptoms and problems. Functional Medicine is a form of integrative medicine that focuses on addressing the root causes of a person’s symptoms rather than merely treating the symptoms themselves and, in this case, manage stress. Here are Dr. J and Evan Brand sharing their insights about different approaches for stress reduction. 

Dr. J suggested to pay attention to nutrients first and some natural herbs such as ashwagandha, rhodiola, holy basil, etc. Watch the whole video to know interesting details about functional medicine in mental health.

Dr. Justin Marchegiani

Dr. Justin Marchegiani

In this episode, we cover:

1:22      Foundation of Functional Medicine Needs

8:27      Emotional Stress

14:50    How to deal with Stress

19:08    Alcohol as Stress Reliever

30:43    Importance of Exercise

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Dr. Justin Marchegiani: And we are live. It’s Dr. J here in the house with Evan. Evan, how are we doing today man? 

Evan Brand: Doing well, the sky is blue, the weather is amazing. I looked at your forecast for this week too, it’s going to be like 75 and sunny all day, every day. So that’s going to be amazing. We’re inside though, maybe we need to do like outside recordings, maybe need to go like, sit out back in a hammock and record with me. So we don’t miss this weather because then it’s going to be cold. And we’re going to be complaining. But no, but long story short, we were talking pre show about just how everything this year has been kind of crazy. And a lot of people are expressing issues with their mental health, their physical health, their emotional health, it’s affecting our clients, it’s affecting potential clients, people that are reaching out to us that have had businesses closed down or potential job losses and a lot of economic issues that have caused a lot of, you know, mental emotional problems for people. So the idea today was, well, let’s try to cover kind of a, a broad stroke, if you will, of how we could use functional medicine to improve mental health. So let’s dive in.

Dr. Justin Marchegiani: Love it. So off the bat, like we kind of go back to like Maslow’s hierarchy of needs, right? That’s kind of like the first thing. So I always tell patients off the bat, there’s kind of a foundation of functional medicine needs, that’s going to be clean water, sleep, and then clean food. And now we can kind of get in the middle of it in the weeds with the food and kind of getting your macros dialed in and getting all that kind of dialed in. But clean water, clean food and good sleep. And so I always tell patients, the more stressed you are, the more you need to be rested, fed and watered. And the more those things are kind of stable, and that’s like your foundation, the better adaptable you will be at the dealing with stress, adapting to stress. So the health, health and stress adaptation are intimately connected. So the more stressed you are, if you start going towards alcohol, and processed food, and staying up too late and watching too much news, it’s going to get that fear cycle going, you’re not going to have enough rest to recharge your parasympathetic nervous system, you’ll be too much sympathetic dominant, you’ll be leaning on your adrenals leaning more on cortisol leaning more on adrenaline, and it’s going to be harder for you to digest. You’ll be just kind of on the edge every time with your emotions, the smallest thing will set you off, and you won’t have a good solid foundation.

Evan Brand: Yeah, I I think people should really just get rid of the social media apps on their phone. I mean, that was something that I did. I just noticed that if I have the social media apps off my phone, and I have to go to a web browser to check them. It’s much much more inconvenient to do it. So I must I’m much less likely to do it. And also, for me, you have the option of being up speaking to that you hear his little notification sound. Oh, social media-

Dr. Justin Marchegiani: – has turned it off right now. Airplane mode, maybe. 

Evan Brand: It’ll, it will, it’s it’s it, you know, there’s been like trials done on how long it takes you to get focused again. And so what I’ve tried to do is to limit my distractions, I think the world now has become a world full of distractions, mainly because people are trying to solve all the world’s problems on their own meaning, you know, I care about the trees getting cut down in the Amazon. So I’m going to go read about this, and then I care about this, I’m going to go read about that. And then you’re so scatterbrained that you kind of lost your own productivity. So I’m not saying that you need to just, you know, put your head in a hole and turn the world’s problems off in your head like they don’t exist. No, I think it’s just a fine line. And I think most people have lost the line of productivity, because they’re so focused on the issues. And a lot of the day to day decisions you make aren’t going to change the world that much like there’s nothing I could do necessarily right this very second, besides maybe donating some money to some organization to stop cutting trees in the Amazon like it sucks. I don’t like to see, you know, you got all this illegal deforestation going on. But there’s only so much you can do. So you got to find a way to to find a healthy way to absorb the media. And most media is negative. So social media, media news. And a lot of it’s not serving you. That’s the only point I have to make.

Dr. Justin Marchegiani: Yeah, I do think number one, social media is a big one, you kind of have to like, use it, don’t let it use you. Right. So turn off the notifications. Don’t let it kind of be there something that you always go to write, I think deleting it from your phone, or at least maybe on the weekends or periodically, deleting it can be helpful because you’re not going to access it as much on the web browser. I think also people forget that most people use social media as their highlight reel. So they only post great things about their life. People feel bad about it. So I’m very aware about that. And I don’t overly post the highlight reel of my life on there because those things are between me and my family and I don’t need to share it with the whole world every now and then. I’ll get people A glimpse, but it doesn’t need to be there all the time. A lot of people overdo that. And people forget that they’re seeing someone else’s highlight reel and they make it makes their life feel a little bit less than or more inferior. And you got to remember that right? You can’t forget it. That gives you kind of a good perspective and a grounding and and it really just comes back to appreciation. Right, the more you’re grounded in appreciation for what you have that that really shifts that that stress and that sympathetic kind of response of just inadequacy and, and, and, and feeling like your life’s not enough.

Evan Brand: Yeah. And there’s people with it, we know that are incredibly successful in business and wealth and all of that. And these people will go publicly bring up their anxiety and depression. So when you look at someone’s life, and you see all they have it so good, I’m so jealous of this or that car, this house or whatever, a lot of people listening may just shut it down immediately. And they say, Oh, no, I don’t care. I’m not comparing myself. But it’s kind of a subconscious thing. You’re not even really aware that it’s happening. Just look up type in, like Instagram depression, there’s some studies done that it was the most depressing social media. So I don’t want to make it the whole anti social media podcast, but you, you hit on gratitude. And I think that’s really the key. So what I tried to do was like a walking gratitude. It’s very, very helpful. So I’ll just, I’ll take the kids outside, and they’ll just walk, whether it’s in the backyard, whether it’s down the driveway, whether it’s in the you know, by the garage, I’ll just find a place to just walk, walk, walk. And I’m just focusing on the motions of the body just shaking up and down, dude. And I’m just thinking, Man, I’m grateful. I’m so grateful. Look at this beautiful day, look at the sun, look at the blue clouds, or the white clouds with the blue sky. Look at the the contrast, look at the green on the trees. Oh, we’ve got a little bit of yellow coming in on these maples over here. This is gorgeous, Oh, look at that red tree over there. And it’ll really take you out of the fear, it’ll take you out of the worry those repetitive, repetitive thoughts, you know, there’s, and this is not talking to one or two people here on my intake form, which thousands of people have submitted, you and I use a couple different form creation tools. I’ve looked at how many submissions we have. And it’s literally like 95% of people out of these thousands have reported? Yes, they beat themselves up with negative self talk. That’s a question on the intake form. Do you beat yourself up with negative self talk? 95%? Say yes. Now is that because you and I have a population who has symptoms and they want to get better? Or is that indicative of the general population to I would say the general population would be the same?

Dr. Justin Marchegiani: Yeah, I always kind of I heard someone say this a couple of years ago, they said, Imagine, you know all the inner thoughts about yourself, kind of write that down. Okay. And imagine if someone else said those things to you? Would you be friends with that person? Probably not. Right? So it’s, it’s amazing how hard people are regarding the inner dialogue. And I always just kind of inner dialogue comes through your brain, ask yourself, would you be friends with that person? If someone else said that to you? Probably not. So I always just try to say to people, you know, make sure you would be friends with the person that would be saying, the inner thoughts that you’re actually thinking.

Evan Brand: Yeah, that’s a good call, that’s a really good call, well, you can be your best friend or you can be your worst enemy. And I think it’s easy to become your worst enemy. Because I don’t know you, you’re the one who has to look in the mirror. Right? So you’re always going to be the one to blame yourself. But.

Dr. Justin Marchegiani: Yep. And if that happens, what do you do? Right? I mean, I think if you have that inner dialogue that kind of shifts overtly negative to yourself, what do you do in NLP world, you go and you visualize the stop sign, right? You don’t beat yourself up over it, you visualize the stop sign, and then you then you shift into appreciation. Or some folks will have the elastic band on the wrist and they’ll pull it tight, right to create that negative neuro Association, whether it’s a physical, elastic snap, or whether it’s a stop sign coming in, that’s that’s visually cueing you to stop, however you want to do it, and then just kind of refocus your energy in a non shameful way to, to the things that you have that are great, right? Because that stuff needs to be you need to it’s like weeds grow automatically negative thoughts grow automatically. It takes no effort to be a cynic. In today’s world takes no effort. It really takes a lot of effort to be an appreciator and to focus on the things that you have. So just kind of use some of those cues to stop the negative thought and then shift over into the positive thought. Now I always find too, if you’re some people, it just kind of feels good to be negative a little bit where you’re kind of venting over something. And if you feel that way, just do it while tapping on some meridian points, some of the EFT meridian points because I find at least if you’re going to be negative, this at least decreases that sympathetic tone. And then what happens is as that that nervous system kind of calms down a little bit, it’s easier to shift back into that positive perspective. So you can do some of the EFT points chin under the nose. under the eye doubletap, I find it’s more efficient for me.

Evan Brand: And as you’re doing this, and as you’re doing this, you’re you’re kind of talking about the negative thoughts, it could be, oh, I just thought about irritable, yeah.

Dr. Justin Marchegiani: Just just talk about whatever it is, I always like to go into it, assigning it a number. So out of 10, 10 being the worst intensity, where, yeah, you had a five or six or seven. And I try to go into it, taking whatever that number is, I want to cut it in half. So if I’m at a seven, I’m going to cut it down to three, or four, if I’m at a six, I want to cut it down to a three, if I’m at a 10 and want to cut it down below five, I just try to go into it, and have that conversation with myself about whatever that thing is that pissed me off, whatever it is that hey, that difficult patient that that really stressful bill, whatever it is, right. And I just kind of go into it, kind of do a little audit of where you’re at, and then try to get that down until it’s at least half below where it’s at, that kind of puts you back in the driver’s seat. And then it gives you the ability to shift to being positive, because you can’t be positive, it’s harder to be positive when you have that emotional staying at a higher level on that on that object subjective scale I gave you. So if you can cut it in half, that gives you the ability now to downshift from negative into positive to enable just want to make that shift. while they’re at a high level of negative it’s too difficult. That’s Oh, man, doing the EFT can be helpful because one, it gives you permission to be negative, but two, you’re giving your your nervous system, a little bit of a bump to be able to neutralize it.

Evan Brand: That is the the best point you’ve made about the emotional stress piece because this is like taking somebody who’s in the middle of a full blown panic attack and saying, Just chill out. 

Dr. Justin Marchegiani: Just chill out, like just relax, like, be be positive, no, can’t do that. Can’t do that. So this is where like the EMDR. And then you can kind of scatter your eyes around while you do it too. Right. So you can go look at like a clock face and go to 1936. Or you can tap while you’re pretending like you’re looking at different clock numbers with your eyes. And because when you move your eyes that uses different cranial nerves, which uses different parts of the brain, and that kind of the whole goal is you’re kind of scattering that signal. Number one, you’re interrupting the pattern. Number two, it’s kind of like if you’re talking about something you ever had it where someone interrupted you and you’re like, What the hell are they talking about? Right? ever have that? That’s kind of what you’re doing a little bit to your brain and in some of the negative thinking you’re trying to scatter that pattern and make it a little bit harder for your brain to go back to and then you’re like, what, what was I mad about? Oh, yeah, that. And then it makes it easier than shift into positive.

Evan Brand: I just tried to go outside to like, for some reason. Well, duh, I mean, humans were meant to be outside. We’re not meant to be in boxes all day. But you know, if you have a thought that is intrusive, you can just go out, and I’ll take a pair of binoculars, and I’ll just go outside and I’ll just watch the birds. Or I’ll go fill up the bird feeder, put it like a sewage feeder. So it’s like a big chunky like fatty CD type feed. I like to go put that out, watch the woodpeckers come in. And if I’m looking at them, and I’m not thinking about anything, yeah, that’s a that’s a great point. So let’s tie the functional medicine piece into what you said because I think what you said is a really good place to pivot which is you can’t take someone because someone listening who’s just so stressed out right now they’re going to they’re going to listen to you talk about tapping or if they’re watching the video on YouTube. So you tap into right What is this guy doing? He’s friggin tapping his forehead. I’m so pissed. I don’t care what what is this gonna do? That person’s a 10. He can’t he can’t even comprehend getting down to a five right now. So So on the maybe you would call it the herbalist functional medicine side, maybe we come in and give that guy or gal a shot of passionflower. Or maybe we give them a couple hundred milligrams of some pharma gabbeh or maybe a little bit of mother wort or maybe some ashwagandha maybe some Holy basil. Maybe we come in with some B vitamins because you and I know based on looking at thousands and thousands of people on organic acids testing that if you’re really really stressed, you’re going to burn out your bees as in Bravo, your B vitamins are going to be toast we know that. Based on looking at these labs, your neurotransmitters are going to be affected. So you may have low dopamine, you may have low serotonin, which is causing more anxiety, but then the low dopamine is causing a lack of energy and lack of drive. So let’s dive into some of these more functional pieces now.

Dr. Justin Marchegiani: Yeah, so we talked about the mindset stuff. We talked about tools to kind of decrease that sympathetic output and it’s just tapping on meridian points, right acupressure acupuncture points, kind of how energy and nervous energy Nervous System energy flows to the body. It’s just helping that energy flow better whether you call it ci or whether you call it action potential or, or nervous system, nerve flow, whatever you want to say, right? blood flow. It’s all connected, right? It’s all connected, right? So off the bat, we were talking about functional stuff. So when you’re stressed What are important things? Well, blood sugar stability is really important because most people get on a rollercoaster of blood sugar. When they get stressed meaning they’re going they’re overly gravitating towards alcohol, or overly gravitating towards refined sugar, their blood sugar goes up and then crashes down. And then it creates more nervous system stimulation via adrenaline and epinephrine being stimulated. And cortisol being stimulated to bring your blood sugar back up. So I find just keep it really simple, really easy with your meals, you may be more nauseous when you’re overly stressed because stress hormone does cause you to feel nauseous. So this is where you may want to do a soup or a simple smoothie, something really easy where there’s not a lot of digestion, but you’re still getting some proteins and fat in there. Whether it’s some collagen and some coconut milk or just sipping on some bone broth, right, something like that is going to have some good fat protein and it won’t be hard to digest. So if you feel nauseous just still no you should probably be eating but just try to make it something very easy on your tummy. And then think what are some of the nutrients your nervous systems in need when you’re more stressed, so low hanging fruit, B vitamins B complex is going to be very essential. Magnesium is going to be excellent gabbeh l-theanine these are good things that are going to help you relax and wind down having kind of mentioned valerian root or passionflower which are all connected to gabbeh and that kind of inhibitory neurotransmitter that helps you just relax a little bit kind of kind of puts the clutch in gear disengages the the gearbox so you can kind of downshift so to speak.

Evan Brand: Did you ever do Kava when you were down in Austin?

Dr. Justin Marchegiani: Yeah, so I mean, I’ve done I’ve done Kava still. 

Evan Brand: Did you go to the bars though? There’s like a cot. There’s like a cup. 

Dr. Justin Marchegiani: Oh, no, I’ve never I’ve never done it at a bar, but I’ve done it. Um, someone brought it over my house. They got it from Fiji. Before I did, it was relaxing. I like Kava that does a lot of gabbeh too, right?

Evan Brand: Yeah, does I felt weird my throat. I felt like well, am I having a reaction to this? Like it numbs your throat so much. It was a bizarre feeling. Yeah, I’m not recommending it. I’m not recommending it as a as a tool. But it could be it could be a good tool. I just thought I’d bring it up. Because when you mentioned like, Valerian I thought, Man, I remember that one time I drink Kava. I was. It was a weird, almost like an out of body relaxation. And I didn’t feel very grounded. It was kind of like whoa, I’m floating in the room. Kind of kind of interesting. 

Dr. Justin Marchegiani: Yeah, I mean, like I always go to nutrients first. And then I go to my favorite adaptogenic herbs second, so ashwagandha is one of my favorites. Right? ashwagandha rhodiola. Excellent. Excellent x, Holy basil those are kind of like my favorite kind of very relaxed, defying, relaxing tonifying kind of herbs, if you will.

Evan Brand: I like it too relaxefying, Do you get any sort of change in your outlook with holy basil? Because for me, that’s the one that’s most significant. Like I feel like I could take on the world when I get like a, I don’t know five 600 milligram a holy basil. It’s kind of like I am ready for the challenge. It’s a weird because it’s I’m calm. But I’m also energized at the same time. Do you get anything like that? 

Dr. Justin Marchegiani: It hasn’t been on my stack for a while. So right now my big stacks on my desk is going to be ashwagandha I do have some some gabbeh chewables and gabbeh sublingual. I mean, I think if you just took people’s works and took, you know, in their, in their place of work, whatever. And you took away all the candy and you just put like magnesium, and you put gabbeh like Lawson jers. Right. Think about how much of a stress reduction had been people’s works. Right. So much better. Maybe some B vitamins.

Evan Brand: Yeah, I mean, if you and I had brick and mortar places what I would do instead of a little you know how old school like front desk, you’ve got a little glass of like lifesavers and peppermints. And a bunch of garbage. I’d have like pre packaged chewable pharma gabbeh sitting there.

Dr. Justin Marchegiani: Yep. chewable pharma gabbeh, sublingual magnesium, maybe some l-theanine shots, right? keep it really simple. I remember in doctor at school before. For finals, we would like make drinks of like ginseng and holy basil. And we like create these like shot glasses all lined up with herbs where we take it. It was fine. I mean, those are some fun times. But um, yeah, so we just got to think a little bit differently and how you deal with stress, just a different mindset change.

Evan Brand: Yeah, I want to go back to what you said how people get into the alcohol and to the sugar and all of that and the carbohydrates and the blood sugar rollercoaster. I think people don’t understand why that happens. So I just want to give people a brief education of why that’s happening from a, you know, neurotransmitter perspective, that way you feel a little more confident that you can change this and you’re not just a victim to the food. So when we look at urine and you measure these neurotransmitter metabolites, we can see that after a period of stress, especially if somebody has been working with us for several years, we can see that Oh, they went through a divorce. Look what happened to their endorphins, for example, the endorphins got burned out. And with the help of Julia Ross, she has an amazing amino acid therapy chart in her books. You can see that the symptoms of low endorphins start to pop up. So these are the people that cry at the drop of the hat. These are the people that hard on the sleeve real emotionally sensitive. If they crave dark chocolate, they’re going for food to comfort themselves or reward themselves. Those are low endorphin signs, we’ll match up those symptoms to the neurotransmitter report on the oat. And then we’ll come in with a therapeutic nutrient like dl phenylalanine, to rebuild the endorphins. And then within four to six weeks, you can have it the 60% difference in symptoms were these people that were running to the cookie because they were stressed or running to the alcohol at night to relax, they no longer need that now, they may still do it. But they literally don’t have the physiological need to do that. Some people say, I just can’t relax until I have that glass of wine. Once you rebuild the brain chemistry, they literally don’t need it anymore.

Dr. Justin Marchegiani: I mean, if you’re having a stressful day, I mean alcohol Don’t get me wrong is that is a wonderful downer. I mean, it really does help relax people. Now obviously, if you’re going to engage in alcohol, keep it to like a drier champagne, a drier white wine, keep it to a clean alcohol and try to do it after you’ve eaten. So you’re not creating a blood sugar swing, because alcohol can actually lower your blood sugar. And then that creates more cravings and more cravings for junky food, right? So if you’re going to have a glass of alcohol, right, don’t want don’t get drunk. But if you’re going to have a glass, make sure it’s a healthy version, then just try to have some good protein before you have it like so if you go out, for instance, have some oysters, maybe a little bit of seafood, maybe a shrimp cocktail and have a glass of champagne or two or a cabo or Prosecco or something clean, clean, clean alcohol. There’s nothing wrong with that, you know, especially if it’s only if it’s not an everyday kind of thing. I think it’s totally fine. And you know, make sure you’re utilizing some of the nutrients we talked about. So you’re supporting the neurotransmitters as well.

Evan Brand: Yeah, check out our podcast, we did a whole one on the whole biohacking alcohol thing. 

Dr. Justin Marchegiani: Yeah, that’s how-

Evan Brand: So, Sunshine, sunshine is huge. I mean, granted, when you’re in certain parts of the country, you really lose the sun, you really lose it because you get clouds. And, you know, if you’re really high northern latitude, it’s really tough to get sun, I’ve got a lot of clients in Canada, and they just get major, major seasonal depression. And so for those people, like a light therapy box can be helpful. I already know for me personally, it’s affected me like when it gets dark at five 6pm. I mean, I just mentally, I just don’t like it. And so the light therapy box can be very good. A lot of times, you’re going to see those at around 10,000. Lux, that’s a pretty bright, pretty bright light. Of course, nothing is going to beat the sunshine. But if it’s like you’re in Alaska, you literally or, you know, hours of sun per day, whereas before it was 12 hours, and now you’re three hours of sunlight. That’s really tough mentally, so sun can be helpful. I wish tanning beds weren’t so controversial. because years ago, I had a friend who worked at a gym who had a level, I think they called it a level three or level four tanning bed, which was not something that closed on you. It wasn’t like magnetic field balanced. Like I measured it, there was no EMF coming from it. But it was almost like the stage lights, almost like a like a theatrical performance, like a red light up at the top. And you could get a tan, I mean, literally in a couple of sessions. But I did it for mental health. And we know that sunlight in general can really help act as almost like morphine, it can really help modulate these opiate receptors in the brain. I remember coming out of a six or seven minute session, and I was just high on life. I felt so good after that. And I thought, wow, I wish this didn’t have to be so controversial. Because if someone could get access to something like this, if we knew that it wasn’t going to increase risk of skin cancers and such, man, what could it do for all the depressed people out there that have Seasonal Affective issues in the winter?

Dr. Justin Marchegiani: Yeah, I think it just comes down to when you’re dealing with sun, it’s just don’t burn, you know, just just don’t get a burn and you’ll be fine. And that’s different for every single person. And so of course, you know, natural sunlight is going to be ideal. I think it’s gonna be excellent. So that’s a good first step for sure. We talked about some of the B vitamins and things and it gets really essential. I think also, you know, just from a financial standpoint, I think it’s really, really good. People talk about it, just having that six month emergency fund, right, try to have, you know, six months of being able to take care of your family, whether it’s food, living mortgage, just try to really make sure at least three to six months if people had that during COVID. I think there’d be way way, way less financial stress for people. I know, it’s a tough thing to do. But I think it’s something to strive for in regards to financial health is just really look for that six months, three to six month emergency fund. I think you’re smart.

Evan Brand: Yeah. And try to get rid of things that you don’t truly need. I mean, I had several people who say oh, you know this or that about budget, but they’ve got the hundred and $40 a month cable bill and they’ve got the the you know, the subscription to this or that that adds up to hundreds and hundreds of dollars a month. So I think with the reducing subscriptions where you can the emergency fund is smarter than from the food security perspective. Two, I remember months ago, you and I were talking about this it was there was talk about some of these meat processing plants and stuff shutting down and I had literally some of my clients freaking out thinking that they were going to run out of meat and not be able to feed their family. I mean, they were probably just watching too much news about the subject. But that’s why I always recommend everyone have a good chest freezer, you can get him for $100 and go on local harvest or eat wild, or just Google local farms around you, we have a farm that I pay him a little bit extra, but they’ll deliver to the house. And we’ll have literally an entire chest freezer full of amazing grass fed meat at anywhere from six to $10 a pound depending on the cut. And we don’t have to worry about going to Whole Foods where we’re going to get shamed if we don’t want to wear a mask, and then we’re buying their overpriced stuff sitting in the fridge. I’ve got my local farm, you know, bringing pastured meats at a fraction of the cost to my door, throw in the chest freezer, I sleep great at night knowing that if something were to happen to the food supply, my children and my wife and I will be well fed. And then of course well what if the electrical grid? Well, I don’t know. That’s that’s, that’s pretty slim chance. I know, people in California worried about that earlier this year, because of the fires, people were thinking, well, what if I have the chest freezer full of meat? And then the electrical grid goes off? Because California turns off my power generator? You know, hopefully, it’s not a long term thing. But you just got a problem solution problem solution, you can’t just get paralyzed by the problems.

Dr. Justin Marchegiani: Yeah, absolutely. You know, I always talk about it, you got to close the loop, right? You know, you have a problem. When you don’t close the loop. And you think about the solution, and you keep these loops, I call them keeping these loops open. That’s where stress happens when you close the loop. That’s where you feel a lot better, because it’s our problem solution. Problem solution, you’re constantly opening and closing loops all day long. That’s kind of how you want to think about it. So you have maximal you know, stress reduction. So we talked about physiology, right? That’s the foundation because remember, that’s like the this is the vehicle This is a suit, the biochemical suit we have to walk through every day and not everyone’s suit is the same and how we can deal with stress. So if you’re looking coming into this, you know, 20 minutes late, you’re like, Well, what do I focus on, focus on the physiological biochemical suit, because that gives you the ability to adapt. And then from there, you can try to grab one or two things that work best for you. mindsets, really important, dealing with some of these stress can be helpful. Talking about some of the supplements can be helpful. Making sure you’re in a good kind of financial situation can be helpful as well. You know, those are all good kind of strategies out of the gates. Anything else you want to talk about functional medicine wise. So we talked about some of the organic acid testing and looking at neurotransmitters that can be helpful, because I find people that are, you know, let’s say long term stressed out people, we’re going to see a lot of neurotransmitter patterns that are pretty depleted regarding amino acids and dopamine and adrenaline and serotonin. And that may be a longer thing you have to work on replacing with amino acids. So that may not be just a supplement you want to dunk on, they may take a while to work on depleting that, especially, you know, the faster it happens when you work on all the sleep stuff and the diet stuff that gets better, but that the bucket that may need some effort to work on depleting.

Evan Brand: Yeah, the only other functional medicine piece we’re going to be looking into for these like super stress, people’s looking into the gut, we’re going to be looking at gut inflammation. We’re going to be looking at parasites, bacterial overgrowth, all the stuff we normally talk about Candida, because there could be some more functional reasons why someone is going into the cookies, for example, or the alcohol, maybe on a neurotransmitter test, they look okay, but in regards to their gut, maybe they have all these bacterial pathogens are parasitic pathogens that are kind of like begging for some sort of quick burning glucose, right? So we may come in. And I noticed personally just using some Mimosa, I was doing some experiments with not not the orange juice cocktail thing, but actual most of the seed most a tree seed in capsule form. That’s very beneficial for calming down my gut. And I noticed mentally I was calm, just by calming down my gut. So don’t forget about the gut brain access, there is a connection there. And so if you’re having digestive problems now, whether that’s due to stress, or whether it’s due to infections, if you’re having diarrhea or constipation, or stomach cramping or food intolerances, you got to try to address those because it does signal and alert Danger, danger to the brain, meaning if you’re going and eating this allergenic food, irritating the gut that can then irritate your brain and cause issues. So I’ve had some people that have gotten anxious after certain foods, and we know that histamine is a neurotransmitter as well. So if you’re having histamine reactions, even just something like a low histamine diet may be useful to help calm the brain down because of some of the reactions there with histamine. So people think it’s just histamine allergies. No, but it can also affect your brain chemistry. And so you got to focus on that maybe herbal anti histamines or something we would use or some enzymes to help to reduce some of the effectiveness of the histamine on the brain. So I think that’s probably my last piece.

Dr. Justin Marchegiani: Yeah, and those are all valid points. For sure. You know, you talked about histamine, you talked about inflammation, and inflamed brains not going to focus and not going to do as well. So again, inflammation, whether it’s food allergens or deeper gut issues is a big one. Also medical palsy women, you know, lower hormone issues can affect the brain. So try to make sure your hormones are at least at a good stable place because that’s going to help with brain inflammation that’s gonna help with cognitive stuff as well. So everyone’s coming at this from a different place from from a different foundational weakness. So just try to figure out where you’re at and take at least one or two steps, you know, Ford on that. Also exercise can be helpful. So just try to find a couple of movements, simple movements that you can do 510 minutes, that’s going to help really decrease a bunch of stress. So whether it’s a push movement, a pull movement, a set or squat, a bender, a pole, whatever that movement pattern is just try to engage in some of these simple movements, it’s going to really help your mood, it’s going to take a lot of that mental energy and allow you to kind of put it out into that physical movement pattern.

Evan Brand: Oh, 100% Yeah, exercise is key. I should have mentioned it earlier. I mean, I feel amazing after I just do some dumbbells or roll machine or hike in the woods, hike in the field, you know, whatever I could do to move. I mean, that’s in its free, right, it’s free, so and you don’t need any permission to do that. So obviously, if you’re going into a gym and you’re doing the whole mass thing in a gym, maybe that’s not as fun so get outside go somewhere where you know, you have your own space and you don’t have people you know, breathing down your neck, so to speak. But I think with the gut piece, the neurotransmitter piece, the aminos here’s kind of the the summary of today and what’s been going on in the world. A lot of people are just like, hey, things are crazy, I give up. But this is actually the time where you really want to dial things in even more. This is a time where you want to focus even more to keep your body keep your mind keep your your sleep patterns healthy. This is not a time where screw it I’m going to go off the rails and just drink a case of beer. It This isn’t the time to do that a lot of people they’re so stressed they have no other coping mechanism. But I would argue everything you and I’ve been talking and doing and preaching and clinically doing for people. This is kind of like the showdown This is like okay, what did all that work we put in actually do did we were we the last man standing, meaning everyone else got burned out and ended up on you know, anti anxiety medication. And we stayed calm and cool through the whole thing. I think this is the time where you can see all the hard work paying off.

Dr. Justin Marchegiani: 100% I think you’re totally kind of dialed in. Also, one thing I’ve been doing a little bit is a little more meditation and just keep it really simple with breathing. Just focus on breath, you can do kind of a biofeedback device like the Muse that I’ve talked about, we’ll put a link down below for that. That’s one thing I’m experimenting more with. It just kind of gives you that little bit of a thumbs up from a biofeedback standpoint that you’re you’re you’re putting your brain in a pretty good place when you’re meditating. I think it gives people confidence. They’re doing it right. The problem I find with meditation, people are like, Am I doing this right? And there’s just insecurity and what the heck they’re doing. And then that prevents them from being compliant with it. So I think having a extra kind of pat on the back yet you’re doing the right You’re doing good with a some kind of a device that helps whether it’s whether it’s HRV, or the Muse or M wave type of technology, these kind of things I think are helpful to give you the confidence that you’re doing something right.

Evan Brand: Yeah, yeah, the floatation tank is awesome. So doing doing a float would be good. deep tissue massage would be great. calming essential oils would be great Epsom salt baths would be great is anything you can do to downshift. We talked about the shifting phenomenon quite a bit, but-

Dr. Justin Marchegiani: There’s a lot, there’s a lot of options for sure.

Evan Brand: Okay, cool. Well, let’s wrap this thing up. So if people need help, we’re here for you. We always have been and we intend to be kind of on the front lines, helping people with all this stuff. So if you need to reach out to Dr. J. is the website. If you need to reach out to me, is the website and we’re here for you. So don’t give up. Don’t give in. You got to keep pushing forward every day, you still got to put your pants on, you still got to do the thing, whether it’s take care of your kids take care of your wife, your husband take care of career, you still got to move forward. So I know it’s easy to get kind of stuck and like you mentioned I like the idea of the open loops closing the loops. I didn’t get stuck in these open loops, but you got to close the doors. Try to simplify try to you know, minimize decision making focus on the big things and you’re going to be just fine.

Dr. Justin Marchegiani: I love it. Excellent and Well, great podcast today to reach out to Evan, to reach out to me we’re available worldwide. If you want to dive in, look deeper at your physiology, biochemistry, neurotransmitters, gut whatever the root issue is. We’re here to help you guys have a phenomenal day. Click down below for all the important links, guys. Take care. Bye.

Evan Brand: Take care now. Bye bye.


Audio Podcast:

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