Chronic Food Allergies and Sensitivities: What’s Really Causing Them | Podcast #451

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In this insightful discussion hosted by Dr. J and Evan Brand, the complexities surrounding chronic food allergies and sensitivities are explored in depth. The speakers elaborate on the alarming increase in food sensitivities among individuals, often tied to significant underlying issues, including gut dysbiosis, stress, hormonal imbalances, and environmental toxins. They provide a comprehensive overview of the physiological interactions leading to food reactions, emphasizing the role of lifestyle, emotional stress, and microbiome health. Furthermore, the conversation touches upon diagnostic testing, such as functional medicine labs, that can reveal critical insights into individual health status. They offer a holistic approach to managing food sensitivities, advocating for dietary adjustments, micronutrient optimization, and more targeted interventions rather than generic prescriptions or supplements.

Highlights

 

Dr. Justin Marchegiani: Hey guys, it's Dr. Justin Marjani. Welcome to the Beyond Wellness Radio podcast. Feel free and head over to justin health.com. We have all of our podcast transcriptions there, as well as video series on different health topics ranging from thyroid to hormones, ketogenic diets, and gluten. While you're there, you can also schedule a consult with myself, Dr.

Jay, and or our colleagues and staff to help dive into any pressing health issues you really wanna get to the root cause on. Again, if you enjoy the podcast, feel free and share the information with friends or family and enjoy the show. And we are live. It's Dr. Jay in the house with Evan Brand. Today we're gonna be talking about chronic food allergies.

We had a lot of patients come in the last few weeks or so that just, they can only tolerate one food or they're incredibly sensitive of supplements or they incredible environmental sensitivities. We're gonna talk about just some of the strategies that we implore and if you're one of these people or you're in between, what are things that you can do and if you wanna dive in, we'll give you options, next steps to also be able to work with us.

Alright guys, let's dive in. Evan. Man. How we doing, brother? Hey,

Evan Brand: what's up man? Doing well. I, I don't have snow, so I'm really happy about that. You've got it. My grandma's got it. Yeah. I don't miss that at all no, I'm still trying to get outside, get sunlight. I went swimming I guess it was, I.

Was it this week or last week? I can't keep track of time with three kids, but anyway, I'm back to swimming. I'm back in the sun, so I'm feeling good. And what I noticed, me personally, is that when I'm doing all the good self-care strategies, I'm less reactive to foods. But when I'm not, when. Getting enough exercise, not getting enough sunlight, I'm too booked up clinically.

That's when I start reacting to more foods. So there's a direct impact of your stress response and your food sensitivities. And I got off the call with a young girl this morning. She's in a finance position. She's working late hours, she's working too many hours and she's working too late, and she's reactive to everything.

She's literally down to eating zucchini, no meats. Oh my God, dude. No fruits. She's reacting to everything. Now, when we did the functional medicine labs, which we're gonna break apart some of these labs today, we uncovered h pylori. We uncovered a lot of gut bacterial overgrowth. We under, we we looked at mold toxicity.

She had a lot of mold toxins in her body. She lives up in the northeast, so there could be a potential for Lyme or co-infections. And so when you start to add significant lifestyle stress, significant infections, significant loads of toxin. You're gonna start reacting to things, and we assume this is probably a mast cell activation issue, but as there's no clinical diagnosis for MAs.

Cell activation. You could do 24 hour histamine urinary, but really it's more of, if you're reacting to anything and everything, it's probably mast cell. I. A

Dr. Justin Marchegiani: hundred percent. Again, the first thing is when you look at most patient's history and how they got here, it's usually a combination of poor diet or some kind of emotional stress, physical stress, or just exposure to maybe antibiotics where it could just be chronic, conventional food and that maybe glyphosate exposure, roundup exposure as it weaken their microbiome.

Chronic stress lessens enzyme levels. It lessens acid levels, it decreases. Bile can also. Activate the sympathetic nervous system, which means less vagus nerve, less parasympathetic, which means less motility. So if you're not moving the intestine, you know the food inside of you and you're not breaking it down well, and let's say you're getting too much antibiotic exposure, let's say in a micro dose via a glyphosate or in a macro dose via actual antibiotics every year.

That can really play a nasty role on your gut. It can make it more permeable. It can make it so the beneficial bacteria in the gut start to go down. Beneficial bacteria like lactobacillus acidophilus, literally has a Latin translation to acid loving. And so these beneficial bacteria produce acids that make it harder for the bad stuff to grow and make it easier for the good stuff to grow.

The good stuff also creates fermentation. It creates vitamin K, it creates certain B vitamins, B12. So it's really important that you have good, healthy bacteria levels for endogenous nutrient production. That means it produces nutrients inside of you, but then also what it does to make the bad stuff have a harder time to grow and what it does for motility, right?

Beneficial bacteria. Help that migrating motor complex work. That's that coordinated wavelike contractions throughout the intestines. That helps that food move through. And if we have lots of dysbiotic bacteria, you're gonna get excess methane, which tends to slow things down. That's the kind of the rotten eggs, flatulence smell.

Or we can have just excess hydrogen. And hydrogen tends to create diarrhea. You could alternate, you could have a combination of the two. It's possible. And that may be more flatulence. That's more neutral smelling, but it's more air. And so it could be a combination of all that. And obviously too, if you have burping issues, it could be you have hydrogen sulfide, it could be a lot of bacteria overgrowth in the stomach.

It could be h pylori. And then of course there could be parasites and candida and other fungal. Are there infections interplaying between the two? And so we like to look at everything holistically, and we always start with the food first.

Evan Brand: Yeah, and that was a mouthful. So if somebody's listening and their mind is already blown, we're gonna break it down for you simply.

And what he's describing is the combination of variables that all makes or breaks your food reactions. And this affects your skin. And this is also gonna affect your emotions and your behavior. So oftentimes when these people are reacting to all these foods, they also have anxiety, they have depression, they have chronic fatigue, they have skin issues.

And so I just want you to make sure. That you wrap your head around. It's not just the food sensitivity, it's also the other symptoms that come along with these infections. And most people are gonna miss that because you're gonna go to the gastro doc, right? They're gonna put you on an acid blocking medication or maybe some other type of pharmaceutical and immune suppressant, who knows now?

They're probably gonna refer out to a psychiatrist or to a, oh, sorry. We got Casey in the Sunshine Band Plan. Wow. That's my ringtone. That's the way Uhhuh. Uhhuh. Yeah. There you go. Okay, so the gastroenterologist is gonna put you on PPIs. I. And then you got the neurologist for the anxiety for the depression.

They're gonna put you on the anti-anxiety med, they're gonna put you on the antidepressant. And so now you're on 3, 4, 5, 6 medications. You're reacting all these foods. You have these mood issues, and that's where things start to spiral outta control because then you come to us, you've got this pharmaceutical list that's so long, but.

If you get the proper data, we can actually fix it. And you mentioned the inability to break down the food as a reason for the food sensitivity. And I would say the best way to look at that is gonna be the GI Map, page four, because we've got Scrt and we have elastase. So we can see if your pancreatic enzyme function is too low.

And then we can see if your. Fecal fat is too high. What else would you say would be an indicator? If you're someone listening and you're like, Hey, I've got these labs already, or maybe I'm gonna order these labs. What other places would you look? I'd say page four. What else?

Dr. Justin Marchegiani: So on that page we like to look at the immunoglobulins.

So immunoglobulin a 'cause that immune mucosal barrier, maybe very weak, right? You have this immune mucosal barrier in your sinuses and your eye cavities, your ears, urinary tract, vaginal canal, urethra, right? It's all gonna be there. It's, that's their first line of immune defense. So if that immunoglobulin A has worn down, that's a sign that intestinal barrier is also weaker and the chance of gut permeability is higher.

As the gut becomes more permeable, you're gonna potentially activate what's called the TH two immune response. That's gonna be the humeral immune response. That's gonna be the. Where your body generates antibodies and when your TH two is excessively overactive, that can stimulate your body going after foods more succinctly.

There are certain medications that have been out for years that are injectable that can increase TH two immune response. We know that because when we wanna develop antibodies to go after certain bugs, that's a good thing, right? But if we overdo it, it can sometimes create a hyperactive immune system that can make your go after foods and be more sensitive.

So we have a th two immune response. So we need to do things to calm that th two immune response down. So the first thing is make sure the foods are not inflammatory. Make sure we can actually break the foods down. You'd be surprised when someone's gut is a disaster. They may have a hard time digesting and breaking foods down.

So that's where bringing an instapot. And can be helpful. I try to stay away from a crockpot because crockpot, while good for the average person, that longer cooking time can increase histamine. And if someone already has mast cell issues or they already have a lot of histamine in their gut because of the bacteria in the gut being off, or they got mold in their environment, that's gonna cause an issue.

And so that's why we use an Insta pot 'cause it cooks. What a crockpot would take eight to 12 hours, does it in 45 minutes, so we have less histamine, so that predigestion can be really good. We work on foundational things like just chewing your food up really well, not overly hydrating with foods. A couple ounces to get pills down, but do it 15 minutes before a meal.

We try to make sure we activate the parasympathetic nervous system. We can do vagal nerve stimulation. I got a vagal nerve over here that I use right in this area, that kind of work on that trigeminal nerve which can activate the vagus nerve. We can do parasympathetic breathing, we can do cold plunging, we can do prayer, we can do meditation, just sitting at your meal.

Before you eat, just say a prayer and be appreciative. Of everything in your life. These things activate the parasympathetic, which is the rest and digest, the sympathetic is go. Fear, fight fight. And so we wanna make sure we're on top of our nervous system function, which is simple modalities.

Evan Brand: Yeah, said. And even in just the last five years, it seems like everybody's stuck in fight or flight. The whole. Pandemic issue and people being stuck in fight or flight from that, I feel like society never fully recovered from it. You tell me if you think differently. Yeah. But when I look around, it seems like everybody's running around like a chicken with their head cut off.

Like everyone is not really grounded. I would say American Society's not very grounded and we have clients in other countries. It seems the same Australia. Canada, like it's everywhere. Yeah. Maybe in less developed countries it's more chill in Costa Rica or something, but I would say in general, people's lifestyles are directly impacting their digestion because they're not ever taking time to even get off their phone long enough to chew their food.

It's just this correct. Let me shove this food down real quick so I can get

Dr. Justin Marchegiani: back to

Evan Brand: my day. Yeah,

Dr. Justin Marchegiani: correct. And when we see these immune imbalances, certain things we can do just to help on the immune wise, just make sure the inflammation and the food is down. So we will look at certain diets, whether it's autoimmune or low fermentable diets.

We're gonna make sure vitamin D, vitamin A and glutathione or optimized 'cause that has a way of enhancing th one. And modulating that TH one, TH two immune balance. So TH one is the cytotoxic immune response. That's the natural killer cells. That's like essentially the Navy Seals the Delta team, right?

That's the special forces going in and the humeral. Immune response. That's the TH two. That's the, let's just say the infantry coming in after the fact. And so when we're two H two th HD two h th two dominant, say that 10 times fast, that's gonna create more food allergy. So vitamin D, vitamin A, glutathione could be helpful.

Zinc, right? Really important for T-cell activation. And promoting th one cytokine responses so we can get that from oysters or seafood. Or we can add in a zinc lozenger if our gut's jacked up. Selenium very helpful Supports. Antiviral activation. So TH one is very important. Selenium bumps that up.

If we're a female and we're anemic, or we're a male and we're vegetarian and we have low iron, that could be a problem too. So those are some of the core nutrients. We'll always look at supporting and glutathione. We can get it up with NAC. That's a good option. If we're really sensitive, we can even do a nebulized glutathione.

That's a good option too. But these can be, or if we're really sensitive, let's get some sun. Let's go out and get some sun or a supplement this time of year in the winter, right? So there are some things that we can do. So when I look at like the immune response, we can push it with supplements, but that's still not the root cause.

We still have to look at the diet, the digestion, lifestyle. Looking at the adrenals, the parasympathetics, and the female or male hormones can be a big thing. 'cause if our female or male hormones are depleted, low progesterone, estrogen dominance, and again, you can have low progesterone and low estrogen and still be estrogen dominant.

Men, low t, these hormones are anabolic. They help you heal, they help you recover. So if we're overly stressed and we're not healing and recover recovering, that's gonna make it hard for your immune system to be healthy. So we wanna look at the hormonal component as well. This sounds like a lot, but it can really be broken down with just a few at-home lab tests, we can do urine and stool and investigate most of this, and our goal is to help you make the most simple but effective protocol.

Evan Brand: And most people that reach out to us have been to 10 or 20 practitioners before and they're taking 20, 30, 40, 50 supplements and they're really no better off. And what's happened in the functional medicine world is functional medicine's actually become somewhat of a bur a buzzword, somewhat of a marketing word.

And so now what you and I have been seeing for the last decade now is that you have some conventional medical doctors that are now transitioning out of practice. They don't wanna deal with the insurance model. They want to go more cash based. They're going functional medicine. And so they just slap functional medicine on their website.

But then when you actually look at these guys' protocols, it's very generic stuff and none of it is root cause. Correct. And so what we do differently. Is we're looking at your actual triggers. Of course we can throw this extra fish oil and this extra whatever at you, but it might not fix your issue. And so that's where I think people are somewhat what's the word, jaded.

Like I deal with skeptics more than I used to because of this marketing effort, meaning the naturopath and whoever, everybody's throwing supplements at everybody, but none of it is laser focused, targeted protocols like what we're doing, it's all just a crap shoot. It's like they went to chat GBT, what are the best 20 supplements I should take for optimal health?

They took all 20. And they wonder why they're not better. And it's because it's not based on your actual data. So for example, if we get this gmap test done on you and we see that you have a dysbiotic bacteria, yeah, we're gonna use specific herbal antibiotics. To address those bugs. We're not just going to give you the zinc, we're gonna give you the herbs to fix the infection.

And so if you feel like you've been jaded and you've bought a bunch of stuff and you're not better, I would just encourage you to look back at that. And was that a root cause targeted protocol or was that just a crap shoot?

Dr. Justin Marchegiani: So great points there. So I had a patient that I saw this morning and the patient started having gut issues in 2021.

I won't give any information out, but just keep it simple. The first thing, her doctor, who was more functional medicine trained functional medicine md, 'cause what the first thing he did was he got her on just primarily hormonal support. Got her run higher dose testosterone, got her run higher dose.

Progesterone and I, my opinion, way too high. I have labs to look at it. You when you're five or six times the lab reference range on the high end, that's too high. But guess what happened? She felt better for a year or two. And then what happened? I. Over time, she got exposed to a LY bug. Some other antibiotics came in, and then the gut issues became 10 times worse, right?

It's because the hormonal support was just covering up the symptoms of the gut. Now, hormones can help because it can put someone more parasympathetic. It can help someone become more anabolic, heal and recover. But if you're not fixing the underlying issue, you're just still covering it up right Now.

That being said. I still like that method over just let's say maybe giving an acid blocker or a steroid drug because that doesn't fix the cause at all and there's more side effects with that, right? But again, you wanna get to the root issue. So if you're seeing a true functional medicine doctor, we're gonna be getting to the root underlying cause.

We're gonna be working on the adrenals. We'll be doing everything together in a sequential plan, not just using hormones to cover up symptoms. That's the difference. And like Gavin said earlier, there's not like this standardized. Residency that a functional medicine doctor goes through. I have learned from some of the best doctors out there.

I also have 5,000 plus patients 15 years full-time, so I've learned a ton. When you interact with a patient, you get tons of data on what works and what doesn't work, and you learn with each patient and there's patterns and there's things that are consistent and tried and true. And so that's, that plays a role.

And there's none of that information in chat, GPT. It's just not there. There's so much that. That is you can't just get online. So much of it is just experience and trial and error. Now you get the underlying physiology in biochemistry, that's important 'cause that's all foundational.

You have to know how the body works, but then how you plug everything in that there's an art to that.

Evan Brand: Yeah, absolutely. I was talking to a friend the other day and he was skeptical about herbs, and I'm like general skepticism is not very helpful. Tell me what is your exact skepticism because, oh, I'm skeptical about herbs.

What do you mean? And so I sent him a paper he was having some sleep issues. I sent him a paper, double blind, placebo controlled trial of passion flower and how passion flower significantly improved the restfulness, the quality of the sleep, the fatigue levels during the day. I'm like, dude, there's a double blind.

How many more do you want? So this stuff is out there and herbal medicine is life changing. You and I don't really call ourselves herbalists, but we are. I don't even think there's a I don't, it's a modality. Yeah. Within

Dr. Justin Marchegiani: our toolbox for sure.

Evan Brand: This is an incredible opportunity and to see people that have had antibiotic resistant infections.

Then we clear those with herbs has been life changing literally. Totally. Totally. So here's what you need to do if you have food sensitivities, food reactions. Do you need a food sensitivity test? I wanna pose that question to you because for me, years ago, I'd run these food sensitivity panels, but after seeing so many people and seeing so many issues pop up, I think that it was creating more fear.

And so I don't run 'em, but what is your opinion? Food sensitivity testing, yay or nay?

Dr. Justin Marchegiani: Yeah, so I typically do not recommend it out of the gate because anyone who has, let's say the analogy I give to patients is, Hey, let's say this food allergy panel says that you have strawberry allergy and then you start eating blueberries.

If you have still have gut permeability, you retest it. Next month it'll probably save blueberries. And now the issue. And so I try to fix the underlying reason why that intestinal barrier is weak. Why the immune system is getting exposed to those foods and why that immune response is there. 'cause that's the underlying issue.

So in the meantime, typically we just say, if you love it, rotate it. Rotate some of your proteins, rotate some of the colors of the carbs that you're eating. I have a lot of the foods organized by taxonomy group. So food, genetics are the most similar proteins together. The least similar. And so we just keep that so that we have a rotation component.

So if someone's very sensitive, we're gonna try to rotate. We're gonna try to cook those foods really well. Instapot it, super stew, make it very easy to digest. If you're really sensitive, we're gonna do more soups or broths. We may even blend it up and just sip it and make it like a nice, thick broth that you sip to get the nutrients in.

So it's really predigested. We may use amino acids that are free form and pre broken down, so they're very easy to digest. We may even use elemental powders. I. There's various kinds that we can do where the amino acids are all in free form, so there's no digestion that has to happen. These are all really good options and food allergy testing can be helpful for people if they're already in a good place and then we've already got some stability and you wanna see what's going on.

That's better. And there's some good ones out there. MRT is good. That's looking not at just that IgG, but other. Immune cell interactions that are happening. So it'll give you a little bit more of a deeper window into just the immune response. Conventional medicine only looks at. Food allergies from a IgE anaphylactic response.

So most people know oh, this kid's got the peanut allergy. They gotta give the school nurse the EpiPen in case he gets exposed. That's like your IgE, your anaphylactic, the throat closing the big hives and welts. That's the skin test they'll do on your back. At the allergist, that's not what we're typically dealing with.

We're typically dealing with chronically chronic delayed allergies that can create inflammation over time. They're more IgE or delay immune. Mediated responses. Totally different what at the food allergist.

Evan Brand: And long story short, if you have infections, toxins, other things disrupting your gut, you're gonna have more false positives on that food sensitivity test.

For example, I had a woman say, Hey, I'm allergic to every single meat on my food allergy test, chicken, Turkey, beep. She was never rotating anything and her diet was like six foods. And so if you're just eating six foods, you're probably gonna end up deeper in the hole. I know that's weird to say, but that's what we've seen.

And ultimately you have to use some mast cell stabilizers. I've got a bottle right here. This is a histamine, mast cell formula that I have now. This one has quercetin, this one has parilla leaf. These work. You can do chromin. You can do kain. You could do some of these pharmaceutical mast cell stabilizers to try and calm your reactivity.

But I would try the nutrients and the nutrients might make it to where you don't need the drugs and you hit on enzymes and you hit on acids in the gut. We talked about how on the stool test, we're gonna look for indicators that we need to add more acids and enzymes. I would also throw DAO into that acid and enzyme Sure box, because I was reacting to histamine foods.

  1. Several years ago, and now I'm significantly better. And I believe what happens is, this is hard to prove, but I believe that if you're supplementing acids, enzymes as well as some extra DAO, you're actually allowing your body to build up its natural reserves and you're not depleting yourself.

Because now I don't need DAO and I have less reactivity to high histamine foods like avocado, pineapple, tomatoes, those are all high histamine foods. And I actually have a histamine food guide. I'll try to put it in the show notes for people.

Dr. Justin Marchegiani: Yeah, and that makes sense because I think, for me.

Ancestral standpoint, we probably were getting organ meats, and a lot of the organ meats, like the kidneys have a lot of DAO in it. So I think from a cultural standpoint, we probably were getting more do naturally in our food. Again, like conventional medicine typically may throw an H one blocker at you, which may be like a Benadryl or a Claritin, right?

Benadryl, like more sedating, CLAT, less sedating. Then you have your H two blockers, which are like your pep a c. That's used for acid reflux, but they're H two histamine two, and then you have the mast cell stabilizing medication. That's the chromin, that's the keto tipin. These are the. Mast cell stabilizing drugs. And then you have the IgE end result, which is the EpiPen, right? Adrena click. These are the epinephrine injectables 'cause of that IgE immune reaction. And then you have other ones like Lucas, right? This is like your your Singulair, those kind of things. Asthma, asthmatics, those kind of things.

So with food allergies, that can be a thing, is what else can drive up your immune response? Let's say you have mold in your air or a lot of allergens from outside. Trees, pollen dander that are in your sinus cavity, you go back inside. Just 'cause you're inside from the outside world doesn't mean all that allergens and antigens aren't in your home and aren't up your nose.

And so you need protocols to clean your air and also clean your sinuses. That plays in a very important role 'cause that can increase that TH two immune response. And if it's upregulated, it can easily start going after foods next.

Evan Brand: And this might sound crazy, but what you're saying is that sinus issues can directly affect not only what's happening with your gut, but also your immune system.

And once again, because of the specialization of medicine, if you go to your gastro doc and you try to talk about how your sinus issues could be affecting your gut, they're probably not gonna help you very much. And we have gastro doctor friends. They're not gonna say You need to do sinus rinses to fix your irritable bowel.

Dr. Justin Marchegiani: And my favorite thing is I use these X layers. This is all use more for like cold season. Because it's got some herbs in there like patco. It's got parsley, it's got eucalyptus, grapefruit seed. Regular is great for just chronic use. Allergens are in the air. This is just grapefruit. And then there's a red one called Max, but I'll just do two squirts.

When you do it, you wanna breathe in. And you know you did it right when you can taste it, go down the back of the pal. Spicy. Are you doing the regular little spicy or the burning? This is the rescue. This one burns. Like my kids are like, I don't want the one that burns. And so sometimes we'll do this one first, then I'll get my sinus flush bottle three second, flush, blow, three second flush, blow.

And then I'll chase it down with the regular, which is a little bit more gentle. And then 2, 2, 2, 2. Or if they're really sensitive, I get the max. 'cause the max has. Capsicum, it has the grapefruit, but it also has the added aloe. So if your kids are sensitive, do that one. But I recommend in cold and flu season rescue all day long, you just gotta suck it up and get a little tough.

That's all,

Evan Brand: that's one of my favorite functional medicine party tricks. I usually buy a few bottles, so I, I. Buy a little bit more in bulk. So I'll usually have an unopened bottle. You'll have a friend or somebody come over complaining about their sinuses and I'll just say, here you go. Let's hit it.

And watching their reactions to that. Yeah. And then also dosing people with extremely bitter herbs is is a guilty pleasure of mine. Like you get somebody that comes over, they're talking about stress or anxiety, and I'll just give 'em like straight ashwagandha, passion, flower tincture. Oh yeah. It's always fun, dude.

I remember,

Dr. Justin Marchegiani: man, like when I was in like. Doctor at school. I remember the finals, like we had finals and stuff, right? I remember a bunch of like us that were really into functional medicine, we got these herbal tinctures and we lined them up. We had ginseng, we had astragalus, we had licorice root, and we literally had lined them up and did like a shot contest going through all of our big herbs before we did a big kind of like studying session.

And so that was fun. Kinda a little nerdy. That's awesome. So why you do these things though? Your nose will run a little bit. 'cause the xl the xylitol will hit the mucus and break it up. It's like dawn soap at a greasy pan. So you wanna blow your nose. I'll spare you the blowing here, and then afterwards you flush.

I had an incident this summer where I had a cough and it lasted for a month and a half. I was doing my sinus flush and it wasn't getting rid of it. I'm like, Justin, what is going on here? I added back in, I forgot the XLE right before. And then when I did it, a whole bunch of extra mucus came out. And so the moral of the story is the X layer is a very important recipe to do before and ideally after the flush.

'cause it can really get stuck mucus that's dripping in the back out.

Evan Brand: Yeah, said Momo. Evan, I've watched you for years. You're looking younger, my friend. I'm sure. Much healthier. Hey, thank you. I wonder sometimes I feel like I'm aging, but I appreciate that and I put on some weight too, I lost 30 pounds.

For people that don't know my story, I. I had parasites. I had h pylori. I was a mess. My gut was a mess. My skin was a mess. Luckily when I was a teenager, my wife saw past that and still loved me through it. But I went through hell and back with my gut. So I totally empathize with you all that.

Have food reactions, that have gut gut sensitivity. Like I went to the conventional gi. They wanted to put me on drugs. I didn't take any of the drugs. I just found nutrition. But then I didn't know I had parasites the whole time. So when you see people which I've been on his show, but when you see people like Paul Saladino doing these influencer videos about just eat more steak, that's all good, but it's not gonna clear Giardia.

It's not gonna clear candida. No. And

Dr. Justin Marchegiani: no,

Evan Brand: if you're watching these. Nutrition influencers online, and you're wondering, why have I done everything that they told me to do? And I still feel like garbage. You've gotta get the data and yeah. So anyway, and then Rafael said here, just joined, but wanted to add, after the virus and the injection, I gained a lot of food sensitivities.

And that's exactly what I discussed with the girl this morning. That's the th two response. We were

Dr. Justin Marchegiani: alluding to.

Evan Brand: Yeah, so this girl this morning who who I told you is reactive to literally every food. I said what was, 'cause she got the injection, the hokey pokey. I said, what was your level of gut issues pre injection?

She rated it a five outta 10. What is your issue now? She rated a 9.5 outta 10. And so I said, okay so that severity, that increase in symptoms. Correlates exactly to the timeline. You got this injection immune system went haywire. Now you're reactive to everything

Dr. Justin Marchegiani: and it makes sense why there, there's certain compounds that are out there that can that can clear those issues out.

And one of those nutrients is corin. Corin can be helpful. Thulin can be helpful, which modulates the immune response. And also systemic enzymes. So we'll even do things like. Nattokinase s Peptidase, we'll even do brom, Moline based enzymes, and that will clear out some of these proteins that are in our blood that could be negatively impacting the immune response.

So we can do that too. And just getting back on anti-aging for one second. Make sure your blood's not glycating. Most people accelerate their aging process 'cause they're glycating, right? Too much sugar, too much carbohydrates that sugarcoats the proteins. That creates free radical stress that creates oxidation, right?

Oxidation cut. Open an avocado, leave it there. What happens? It browns now go squeeze a little bit of lemon juice on it. What happens? It stays fine, right? That's what happens. So measure your blood sugar. Fasting. One hour, two hour, three hour. Don't get below one 20 to one 30 in the first hour. Back below a hundred with an hour two to three.

That will make sure your glycations under control. Adjust your carbs accordingly. Don't get too much sun where you burn. Sun is good. Just don't burn and use good moisturizer on your skin. I like emo oil. Keep your skin moist. That will help on the aging side for sure. Simple things there.

Evan Brand: Did you say you do emo oil on

Dr. Justin Marchegiani: your face?

Is that right? Yes. Okay. Emo oil is wonderful. Yeah, that's, it's basically like an ostrich, like bird. Emu oil is used in some of the biggest burn victim units on like literally. Know, level three burn victims, right? We're talking burn all the way through the epidermis and dermis full on, skin graft.

And it is one of the most healing anti-inflammatory oils. It's not too expensive. There's a lot of products that are out there that are good, but they're very expensive emo oils in the grasp of almost anyone that wants to care for their skin. And so that's why I like it and I've seen it be used at.

Patients that are full body grade three, level three burns. And so I see it have good results and so very good. And it's also non-com genic will not clog the pores and it's also bacteria static will also, help with microbes on the skin, like the cutie bacteria, acne bacteria. I. Super cool.

Evan Brand: Okay, so what do people need to know in regards to the testing?

We discussed that. Yep. Food sensitivity testing may not be helpful in this phase. I know you think that's the first test to go to because you're like, I have these reactions. I want clear evidence of what I'm reacting to. But the unfortunate part is when your immune system is dysregulated, it might not be the best data, and so we're gonna push you more towards the functional labs that's gonna be.

Potentially hormone testing. This could be like a Dutch panel. This could be an organic acids, a mycotoxin screen to look for mold. We could do toxic chemicals to look for glyphosate and other compounds disrupting the gut. And then obviously we want to get a stool panel on you as well. So urine install, these are done at home.

We order those for you. You do those at home, you mail those back to the lab, we get the results, we'll jump on a call. We work worldwide, and then we'll make a protocol that's gonna help address that. Yep. Couple. So we talked about lab stuff, talked about some of the gut testing. We can look at hormones, right?

Dr. Justin Marchegiani: We can look at organic acids, which give us another look into the gut via urinary metabolites. Looks at candida yeast. It can look at colonized mold in the gut. We may test the home. We may test the home for mold if someone's chronically immune. Sensitive. We wanna make sure the home is dialed in. We're definitely getting air filtration.

That's a no brainer. We're definitely doing sinus flushes just to make sure the immune system is not reactive. And again, if we have congestion that drives more suspicion into that area. See here talked about testing. What we can do now we can look deeper at gut bacteria. Again, probiotics, prebiotics can be helpful, but with a lot of these patients, it makes the problem worse because they already have an imbalance in the microbiome.

So that may be something we utilize, but just not right now. Timing is everything. Patients that have been through the ringer, they're like I've done this. It didn't work, done this, it didn't work. It's like the timing is everything. If I gave you a recipe and you mix the flour and you add the eggs in, after you baked it, it's gonna come out like garbage, right?

So the timing is everything. So probiotics, prebiotics. Timing. We may add in curcumin, we may add in quercetin, we may add in collagen or free amino acids or maybe some kind of an elemental diet or maybe even a zero fiber diet. Initially, we look at vitamin D, vitamin A, zincs, selenium. I mentioned that we're gonna look at go organic, or at least make sure there's no glyphosate on your food.

Glyphosate was patented as an antibiotic originally, that could be knocking down your healthy gut microbiome. People talk about FMTs fecal microbial transplants. I've seen them be totally hit or miss, and some people even make 'em worse. I wanna get your take on that. I think it's a panacea, like that's like the functional medicine world, like the conventional doctors taking some of the functional medicine stuff and it's just, it's a hit or miss and mostly doesn't move the needle or not.

And then also, where do you get the transplant from? I do they have an infection? Do they have h pylori? What's happening with that? What's your

Evan Brand: take? My take is I've had people that have done fecal transplants and it actually changed their personality. And there's studies on that. If you just Google FMT personality, I've had people that all of a sudden have new food cravings for french fries, or all of a sudden they want pizza.

And so there's literally memories stored in our gut microbiome and. Parts of our personality are coming from our gut rather than our brain. I've seen people become more anxious. I've seen be people become more depressed. I've seen people become less depressed, less anxious, and so I've seen a handful of the fecal transplant people.

But lemme tell you this, I've never seen it stick. I. Like you said with the hormone story earlier, maybe someone says they've got a little bit of relief for a few months, and then I think their body's Hey, I know what you did here, and then they go back to their old self. So I've never seen it as like a cure all.

Dr. Justin Marchegiani: Yeah, I've seen the same thing. And also I've seen people actually get worse because are they really doing comprehensive gut testing on the people they're getting the transplant from?

Evan Brand: You

Dr. Justin Marchegiani: could be giving yourself an infection, you could be giving yourself h pylori. You don't know.

Evan Brand: Yeah.

Dr. Justin Marchegiani: So that's a big issue.

Yeah. And then of course a lot of the adrenal support, guess what can help The th one immune response. So getting the hormones stable can help and we gotta make sure the food is dialed in and is tight, and it's not just the food, but it's also how it's cooked. And making sure we have our enzymes, our acid in our bile, and chewing.

All dialed in and we gotta work on the parasympathetic. That's where sometimes adding in like A-D-N-R-S program or you'll see some of these PRO protocols like EEFT or NLP, there's different protocols that can be very helpful. The Gupta program that can help if someone's really stressed or has different traumas in the past that are just keeping their nervous system just on absolute overdrive.

Those things can be very helpful to add in. If everything else is not working.

Evan Brand: Yep. So check out the links below. We'll put a link. We've got a histamine guide. We got some supplements you can try out. These are just like some low hanging fruit. Ultimately, get the data test. Don't guess with your health.

We'd be happy to build a customized protocol based on what we find. You can reach out to Dr. j@justinhealth.com worldwide. Consults available Dr. J just in health.com or me, Evan brand@evanbrand.com. We'd love the opportunity to help you all. We're so fortunate to have. 10,000 plus between US cases under our belt now combined total 20 plus years, and it's been a ride and we're still learning and we're still implementing.

And so we want you to know that we are staying on top of everything. We dive into PubMed, we look at studies, we look at research to not only help ourselves clinically, but also for the show. So we want to give you all the most up-to-date info we can, and we wanna learn and we wanna continue to be lifelong students as well as practitioners.

So jump on, have some fun with us. Let's get you feeling good.

Dr. Justin Marchegiani: And I get it. It's a lot of information, so just take one thing, apply it, and then if you're still at a standstill, evan brand.com for evan justin health.com for myself, Dr. Jay, and we are here to help and just share this with one family member that could benefit to it.

This is a lot of stuff out there, a lot of misinformation. We want to give you information that's we're in the trenches using it and applying it. It's not just something that we got from chat GPT, right? We're using it. We're doing it right. So hope it helps. And Evan, great podcast then man.

Really good.

Evan Brand: Yeah, man. You too. And a buddy a guy who sings at church. He sent me a screenshot Yeah. Before we jumped on of him listening to our podcast episode we did on headaches recently. Oh. Yeah. Nice. So he's, and he's gonna spread it with his friends. And so this is what we need.

We, we need people to learn that there is an alternative model here that is in much ways, and in a lot of ways, it's better because these gut issues that go unresolved. Crohn's, ulcerative colitis, colon cancer, irritable bowel diseases, like this stuff gets more serious. We wanna help you before it even gets to that point.

If you're to that point, we can help as well. We have a lot of experience with autoimmune, but man, I tell you like don't just eat the garbage until you're bleeding outta your butt. If you see something is off, yes, let's get you better before you're to that point of ulceration

Dr. Justin Marchegiani: and get screened by your conventional doctor.

At least let them screen you. But then you can kinda look at both options and make a decision from there. Yeah. So awesome guys. Nice chatting with y'all and Evan. Great my man. We'll talk soon. Cheers. Peace.

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