Dr. Justin Marchegiani and Evan Brand dive into the topic of blood test analysis—specifically the Complete Metabolic Profile (CMP). Learn about the different markers that they look into like the glucose, calcium, BUN, creatinine, Alanine Aminotransferase (ALT), Aspartame Aminotransferase (AST), potassium and sodium. Know about the different symptoms and health conditions associated with the different blood markers.
Gain some valuable information about functional ranges in blood work and understand how it can provide more information regarding health issues and nutritional deficiencies compared to the general reference range. And lastly, discover some healthy recommendations to address nutritional deficiencies.
In this episode, we cover:
2:56 Glucose Marker
6:10 Calcium Marker
8:20 Protein Marker
10:30 BUN:Creatinine
14:12 Liver Markers
Dr. Justin Marchegiani: Hey there! It’s Dr. Justin Marchegiani. I’m with Evan. We’re live on Facebook and YouTube. We’re ready for an awesome podcast. My baby’s doing one week exactly from now we’re really, really stoked. Uh—maybe do a live podcast uh— from the operating room, probably not but maybe something that week, give people some live updates. Evan, how we doin’, brother?
Evan Brand: Life is good. It's back to school season, so all the school buses are around the city and when people go back to school all of our female clients especially the teachers they start having flare ups of their symptoms. So we got to keep you under control ladies and teachers and men teachers as well. Make sure you're taking your adaptogens, if you're going back to school and you're starting up your teaching again. This is a good time to whip out your—your adaptogen formulas and double the dose of those.
Dr. Justin Marchegiani: Love it. Totally makes sense. Also, congratulations on the new car. You got a great deal on a— on a pre-owned Tesla which is really exciting.
Evan Brand: Yeah. It’s like dropping a spaceship. I’m gonna be putting up a YouTube video. Jack Cruise, who is a mutual friend of ours, he said, “Oh my God Teslas are the worst cars for EMF but that's actually not true. I've actually measured using several devices the EMF from a Tesla. It’s actually not bad. It's actually less, believe it or not, than Honda Accord that I was driving beforehand. I didn’t take a video so people just have to take my word for it, but the Honda Accord in the backseat where the baby was, I was actually measuring 4 mill gauss, which is a pretty high magnetic field. The Tesla's actually less than that. So videos and content to come.
Dr. Justin Marchegiani: Unreal. Very cool, man. Well, everything is going here in this front. I’m excited chat with you about today's topic. Uh—let’s dive in. So, we talked about blood tests in the past.
Evan Brand: Yeah.
Dr. Justin Marchegiani: We talked about the comprehensive—I’m sorry, the uh— complete blood count, the CBC, alright, which is some really cool marker. We chatted about some of the anemia and the B vitamin markers and such. Really cool stuff. Today we want to chat about the comprehensive metabolic profile, the CMP, for short. So really excited to chat about that. Now, let’s go over what the CMP is. So, off the bat, I’ll just kinda give you the list here and we’ll hit the most important ones. Number one: glucose, calcium, we have protein markers, albumin, and total protein. We have electrolytes, including sodium, potassium CO2, and chloride. We have some kidney markers/protein markers including BUN and creatinine. And we have some liver markers including a ALP or alkaline phosphatase, ALT which is alanine aminotransferase or SG PTZ 01. And we have AST or aspartame aminotransferase AST or SGOT, for short. We have bilirubin as well. So let's start off first with some of the simple ones. So, we have glucose. That’s a really good set kinda general marker. That marker’s gonna be used to look at diabetes, right? 126 or higher is gonna be your diabetes marker. And again, 110 or higher for pre-diabetes and typically, our functional range is gonna be greater than the hundred in the morning is gonna be uh— good a general indicator. Again, glucose fasting is kind of a late stage indicator. It’s not something we want to use as our way to pick up blood sugar abnormalities, in general. I like looking at a functional glucose tolerance. Kind of you can look at fasting in the morning sometimes that can be higher from a cortisol or stress response, otherwise known as the Dawn phenomenon or the somogyi effect. Typically, I like to look at fasting glucose during the day from a functional perspective. So we do a functional glucose tolerance. We tested fasting, let’s say, breakfast, lunch, or dinner and then we look at a 1, 2, 3 hour post meal and just see how that blood sugar is responding. We like below 140 within an hour. Below 120 in two hours and below a hundred in 3. That's a good general rule of thumb. Ideally, below 120 in one hour and then back around 110 to 100 within two hours and definitely, below 103. That’s—that’s kinda my range. The goal is less blood sugar means less insulin spiking, which is a good thing.
Evan Brand: Yeah, which means less fat storage, too. So when we’re talking about people with uh— a fat loss goal. You’ve gotta have relatively low insulin to be able to do that. If you've got high insulin all the time coz you’re eating refined carbs and sugars, blood sugar goes up, insulin goes up, you can't burn fat. So that's a really good foundational mark to hit on.
Dr. Justin Marchegiani: Absolutely. I think we need to get a Topo Chico as a—as a sponsor for the show. I love the Topo Chico. It’s like uh—kinda like the sparkling Pellegrino we use here in Texas kinda like a Mexican sparkling water. Uh— absolutely love it.
Evan Brand: Why don’t you email them?
Dr. Justin Marchegiani: I will. I’ll email them. I’ll make them our show sponsor. I mean, this stuff is awesome, man. It’s like, you know, I used to be a soda addict when I was younger. And I kinda have those, you know, nostalgic memories of drinking out of the glass coke bottle, so it kinda brings it back here.
Evan Brand: [laughs] We need to email them. Just tell them. I mean it doesn't hurt to ask. So put that on your to do list for today.
Dr. Justin Marchegiani: We’ll get Lululemon as a show sponsor and then we’ll get Topo Chico as the show sponsor.
Evan Brand: That sounds great.
Dr. Justin Marchegiani: Hey, you know, while you're at it, we might as well reach out to Elon Musk and see if we can get Tesla on board, man. That’d be nice for some complimentary free cars.
Evan Brand: That would be great. I don’t know if that will happen with the—the demand right now.
Dr. Justin Marchegiani: I know. I don’t think that will happen. We’re not the Joe Rogan podcast yet. Alright, so any comments on the blood sugar piece we just uh— brought up?
Evan Brand: Yeah. The blood sugar—you're always gonna get that run. So this podcast people may say why are you doing this on blood? Your— you guys focus on functional medicine. Well because a lot of people anybody— anybody down the street, your neighbor, your friend, or family likely has some of the metabolic panel stuff that we’re outlining today, plus the CBC from our other blood test podcast, and so, this is designed where if you don't have functional labs, how can we help you to identify these basic labs at everyone under the sun has access to, regardless of what country you're in. So yeah, glucose, I think you—I think you killed it with that one in terms of the range. Let’s move on what—what else is on your plate here?
Dr. Justin Marchegiani: Well, we can chat about calcium, too. So calcium is a pretty good marker just for overall blood calcium. Again, blood calcium has to drop down pretty low for them to be a nutritional deficiency.
Evan Brand: Yeah.
Dr. Justin Marchegiani: And calcium, one of the things I look at when I see calcium go too low, is potential hypochlohydria. Well number one, are we consuming enough leafy greens, right? That's gonna be a major source of calcium, uh— salmon with the bones major source of calcium. Of course, some dairy products are gonna be great but it just depends, right? Well just use grass-fed butter and ghee over any of the milk and cheese stuff. And if you’re gonna do milk and cheese, you want to make sure that we can—we’re not reacting to. We’re not autoimmune and we’re also, you know, trying to choose raw, organic sources to prevent hormones, the antibodies and also have the enzymes intact to be able to process it. But when I see calcium go too high or too low, I think, potentially nutrient deficiency is number one, right? Not getting the right foods. And I also think low stomach acid and enzymes, number two. And if see calcium go high, a lot of times calcium can be utilized as an inflammatory mediator. So I also look at inflammatory markers when I see high calcium on a flipside.
Evan Brand: Yup. Interesting. Yes. So uh—hypochlorydia, these are the people been popping tums because they’ve got heartburn but in reality they could have something like H. pylori infection or they've been on prescription acid blockers which are very, very, very, very common. So if you’re looking at your calcium even if it's out, sometimes it may be out of the general reference range, let alone our functional range then that's an issue. Do you have a functional range for us since a lot of people are in the US we may be able to give the measure of units for calcium. Do you have that in front of you?
Dr. Justin Marchegiani: Typically, the calcium range, if I remember correctly will be in the mid 9’s. I think it’s like low 8’s to upper 10. Low 8, upper 8 to low 10’s. So I like in the mid 9’s, it’s a pretty good place. Typically, in the middle of the range, tend to be okay.
Evan Brand: Okay.
Dr. Justin Marchegiani: Any comments on the calcium component?
Evan Brand: No. I think you’re doing good. I’m just kinda uh—walk your hand through this. What's— what's next on our list?
Dr. Justin Marchegiani: Yes. So again, I like kinda the middle of the reference range. But next would be uh—protein markers, alright. So we have a couple of protein markers. We have albumin and total protein. And then we also have bun and creatinine, alright. Those are some pretty good markers that we utilize off the bat when it comes to proteins. So number one, I like creatinine above .79. It’s a pretty good place to go right above .79. So for below .79 or maybe some low-protein. And creatinine is a breakdown product of protein as well, alright. It’s a breakdown product, so above .79 if creatinine’s too high, it could potentially be some inflammation going on. It's very possible there could be some inflammation happening. Uhm— there could be a high workout happening where you know we had a lot of exercise the day before and then we’re breaking down a lot of amino acids from the muscle, right? That's one component. And then next is inflammation, too, right? There could be some breakdown from inflammation like your kinda—your body’s more in a catabolic state and you’re breaking down. But it can be a good window into protein levels uh—high or low. And then if we look at total protein, I like in the 7. 7 or above is a pretty good place for pro— total protein. If I see it lower, of course, I’m gonna make sure are we eating enough protein? Are we getting about, you know, half a gram per pound of bodyweight? That’s a pretty good rule of thumb, right? They say that 1.2 g per kilogram, right? What does that mean? People don’t think in kilograms in the US, so, I think about a half a gram of protein per pound of body weight. So if I weigh 200 pounds that's 100 pounds approaching. If I weigh a 150 pounds,
Evan Brand: 100 pounds [laughs]
Dr. Justin Marchegiani: I’m sorry—If I weigh uh— 200 pounds, that’s a 100 grams of protein. If I weigh a 150 pounds, that’s 75 g of protein. And then a good rule of thumb—
Evan Brand: I like your diet, man. A 100 pounds—
Dr. Justin Marchegiani: Yeah. I know, man. That’s it. Exactly.
Evan Brand: Let’s do the BUN: creatinine ratio. So this is something that we see often where this is off. So optimal range, I’ve got a couple pieces of literature here optimal range of BUN: creatinine ratio is gonna be 10:16. A lot of times, we’ll see this altered, where the BUN: creatinine ratio is high. Whether above 16, a couple notes could be antibiotics, could be dehydration, and then in bad cases, some type of G.I. bleeding. So that's not good. And then you've got low issues, where your BUN: creatinine ratio is below 10. This would be issues like we see pretty often. So this would be liver dysfunction, once again, antibiotics, also a diet that’s low in protein. So a lot of older people, I mean, you and I work with a lot of people above age 50, so 50, 60,70-year-olds, they eat less and less protein. It seems they just forget that it's important they start eating snack foods or their appetite just goes down because they've got low stomach acid so they do start to get a distaste for meat. So you’ve really got to use enzymes and HCl with them, ox bile, get their gallbladder working better because if they don't have a taste for protein, it’s gonna be tough for us to say, you know, “Hey Jack, Hey Jill, we've got to get you to eat more protein.” So if you are having a BUN level that is low, or the BUN: creatinine ratio, the BUN: creatinine ratio is low, you might have just a simple issue like not enough protein in the diet.
Dr. Justin Marchegiani: Oh, exactly. Yup. A hundred percent. Now, we talked about creatinine. Now, I’m just gonna crystallize BUN a little bit more. So we talked about creatinine going high, right? Uhm—the potential dehydration as well, potential kind of catabolic physiology rights. That can be a big one. It could be a lot of uhm— creatine supplementation, right? That can be one aspect of—of going high. I just gotta keep that in mind. And on the lower side, of course, will be the protein, right? The low-protein not getting enough of that in there, is really, really important. And then on the BUN side. BUN’s a Blood Urea Nitrogen. That’s another breakdown product. On the high side, we look at hypochlorydia, we can also look at adrenal and dysbiosis, right? And then on the low side, it can be malabsorption, low-protein and low enzymes and liver issues. So there’s a handful of different things that can be implicated either way. I love those as a good rule of thumb of what's happening. And then we could also look at albumin and globulin. And if we see imbalances in the albumin and globulin, that can also mean issues with protein as well. So if we see like albumin to globulin, I think is on the higher side for globulin and the lower side for albumin, we’re also gonna think of potentially more protein issues.
Evan Brand: Yes. So let’s talk about the biomarkers here. You know, Justin and I are talking about functional ranges. You can make it your blood work if you have it in front of you. You may look at that. It may look okay and actually be in range. According to all the sick people that have been in that clinic. So we’re trying functional ranges. So even if something's not flagged low or high, or using specific markers, Justin and I have taken some extra training in terms of functional blood chemistry analysis. So we've got a tighter reference range. So if you don't see anything out of range on your paper, it might not be, but the functional range is much, much, much tighter and that's where we find the issues.
Dr. Justin Marchegiani: Exactly. Typically, it’s gonna be the bottom fifth or the bottom and top 15 to 20% we look at more frequently, like with some of the protein things, some of the albumin high or low. If it's on the high side, we may think dehydration; if it’s on the low side, we may think low stomach acid or enzymes. And some of these markers kinda contradict themselves, so you wanna kinda look at the complete picture so you can get a window of what's happening. So I mentioned some of the albumin uhm—there. If you wanna comment on that at all, Evan?
Evan Brand: I was gonna move onto the AST. I had AST notes in front of me. Did you want to hit ALT and AST, the liver markers?
Dr. Justin Marchegiani: Uhm—yeah. Let’s hit that next. It’s one of the common— one more thing on the globulin—So globulin is also one of those things for oxidative stress. So we see globulin go on the high side, that can also mean oxidative stress. Oxidative stress are like, you know, free radical things, right? Oxidation is a loss of electrons. The more you're losing electrons, the more you want extra antioxidants to help support you out, whether it's antioxidant, herbs like curcumin, or resveratrol, or green tea, or things like vitamin C, vitamin A, vitamin E. Those kind of things are really helpful. So we have albumin and globulin; We have creatinine; We have total protein; We have uh—those are big protein markers there.
Evan Brand: Good.
Dr. Justin Marchegiani: Next, let’s hit the liver enzymes.
Evan Brand: Yeah. The AST to ALT. I wanted to hit on these because, you know, for my— whether it's my grandparents, or some of the in-laws, always see markers off with AST and ALT even outside of the conventional range these are some of the markers and I’m gonna see off. So let me give people a bit of background on the— what they call the SGOT, also known as the AST. So this is an enzyme that’s very, very, very prevalent in skeletal muscle, liver, heart, kidneys and lungs. The enzyme can be liberated into the bloodstream following cell damage or destruction. So optimal range here is gonna be 10 to 30 units of A— of AST. If you're out of the rain, so if you're too high, this could just be liver dysfunction. So some of the reasons Justin and I may look at your AST and its high, it could be anything that's affecting the liver. So this could be parasites, this could be bacterial overgrowth, this could be yeast, this could be chemical toxins, like glyphosate. If your diet is not very rich in organic foods, this could be gasoline additives, which is why I got rid of a gas-powered car because my gasoline additives were off the charts on my GPL toxic chemical profile test. Uhm— you've got a potential for developing congestive heart failure. So if AST is above 30, so AST—if it’s above 30, and then you’ve got these other symptoms like you have a hunger, your yawning frequently, you've got some edema, some of that swelling in the ankles at the end of the day, you’ve got a little bit of shortness of breath with moderate exertion, that may point a picture to some congestive heart failure. That's possible. Now, the good thing is a lot of that stuff is reversible, but these are just signs that things could go bad. Uhm—and then on AST, you've got liver cell damage. That's possible. So alcohol, that’s huge. We see that a lot with previous alcoholics. People who are trying to get off alcoholics. If it's tied into the liver, you're thinking, “If my AST's high, what's going on with my— with my liver? Is that the problem?” It could be. Symptoms would be pain between shoulder blades, you’ve got a headache sometimes over the eye, you’ve got those phase 2 liver detox problems, like you're sensitive to perfumes, or you're sensitive to fragrances, or you're sensitive to car exhaust fumes, that's a big one. Hemorrhoids, varicose veins—that's also tied into the liver, and excessive muscle breakdown. So if you’re doing a bunch of CrossFit exercise and then you got your bloodwork done, it's possible the AST could show up high there and that's not a bad thing. Uhm—
Dr. Justin Marchegiani: Absolutely.
Evan Brand: We got the low side of AST which I won't take too long to go over but B6 deficiencies, alcoholism. So B6 as we know, Justin and I have talked about it a million times, alcohol burns through some of your vitamin and mineral reserves, so B6 is one of them. And then once again, protein deficiency or malabsorption. So AST, either way, if it's high or low, your out of that 10 to 30 functional range, we can find a lot of good information out about you.
Dr. Justin Marchegiani: Absolutely. So let’s go see what once—what we have reviewed so far. so we hit the uhm—the liver enzymes. And again, liver ALT, the alanine, the “L”part, that tends to be more liver, where the AS can be—tend to be more in the heart side, tend to be more on the heart and the skeletal muscle side. So kinda keep that in the back of your head there. We’re looking at these things. So a heart attack, we may see more of the AST elevated and uhm— liver stress more of the uh— more the AST for the heart and skeletal muscle, more liver for the ALT. But again, things like gluten can easily raise ALT. I've seen that. Also, just excessive exercise before, within 48 hours of the blood test could easily raise them of some of those enzymes as well. So kinda keep that in the back your mind.
Evan Brand: Okay. Yeah. I mean, same thing, I want—it sounds like I'd be repeating myself before going over ALT, but functional range for ALT, 10 to 30.
Dr. Justin Marchegiani: Yup.
Evan Brand: Once again is the units. And if people had been doing a lot of uhm— aspirin that could also cause the ALT to go up. So if you're just somebody who popped—uh chronically pops aspirin, your ALT may go up there. Once again,
alcohols gonna throw off your— your ALT. So pretty common sense really.
Dr. Justin Marchegiani: Yeah. Exactly. And we may also see—if we look at bilirubin, which is a breakdown of a lot of the red blood cells, and if we have excessive breakdown, we may look at potential gallbladder issues or liver, gallbladder stuff going on. So we like, you know, typically, you know, below 1.2 or so, is pretty good for the bilirubin in the gallbladder. If not, we may think there’s some kind of gallbladder issue. We may look at food allergen. We mat really up the bile salts and HCl's and and lipolitic enzymes— enzymes that really help the fat digestion.
Evan Brand: Yep. Yep. We've got— we've got a little bit of time left. Should we answer some of these questions here?
Dr. Justin Marchegiani: Yeah. I think so. And the only thing would say is uhm—some of the sodium and potassium and chloride, if we see some of the sodium low, we may think adrenal dysfunctions. If we see some of the potassium excessively high, right, we might think that’s an adrenal pattern of low sodium, high potassium. If we see lower potassium in general, we may think you’re not getting enough potassium, right? We need 4700 mg of potassium a day, so we have to make sure that is kinda dialed in. Same thing with the chloride, I mean, the real easy thing is with the minerals, is number one, we’re getting sea salt in our water, right? High-quality sea salt in our water, half a teaspoon twice a day, we’re eating lots of green vegetables, either cooked, or juiced, or made in away so you can process and digest it down. And then fix the adrenals. These are all things that are gonna commonly be thrown off by adrenal and mineral imbalances. And sugar and insulin can also throw that off, too. Well, adrenal dysfunction.
Evan Brand: Well said. Uh—we got question from—I believe it's Nalema. Do you have to worry about potassium intake if your bloodwork does not show a deficiency? If you're eating a pretty good paleo template, I mean, for example you and I have chatted about our love for avocados, you're gonna get much more potassium in avocados and bananas. So I think if you're eating an avocado a day or every couple of days, potassium is probably not an issue. What’s your take?
Dr. Justin Marchegiani: Yeah. We’re gonna get one avocado, you get about 1 g a day. You need 4700 mg or 4.7 g. So I would say, if you’re doing six servings of green vegetables a day and you're doing one avocado, you're probably gonna be okay. But I will just throw it into chronometer. Put your height and weight and just ensure that you are getting that 4700 mg, which again is really easy to not get. I think that’s the DRI. That's the Daily Recommended Intake, not the RDA which is the Recommended Daily Allowance. So 4700 mg, probably good with two servings, probably six servings of veggies and an avocado a day, you'll probably be okay, but just run it through chronometer to double check.
Evan Brand: Okay. Cool Samuel—uhm a bit off topic. We’ll do a whole show on this. “How do you feel about making your home a smart home?” “Does it create negative effects from EMF like adding nest products and Phillips hue lights?” Not a fan of uh— LED lighting. I’ve chatted with Mercola about that on my podcast and yes, the nest and all the wireless technology, I do avoid that. I'm hardwired everything. No Wi-Fi, hardwired Ethernet. And uh—funny enough I'd been wanting to turn off the breaker to our bedroom so we could sleep better. And all the sudden the power to the bedroom has been off, but all the breakers look fine. So I don't know if someone from the universe magically cut off the power to our bedroom, but even though the breakers look normal, there is no power in the bedroom and I've been surprisingly sleeping way deeper. Uhm— but we could do a whole show on that, but ideally you stay away from the wireless stuff or you just turn down the intensity of your— your products if you can.
Dr. Justin Marchegiani: Yeah. I’m on the opposite side of that. You have the nest. I do have the nest. I do love it. I think it's absolutely awesome. Uhm— and again, for me, I have my Wi-Fi on a wireless timer so once 11-11:30 hits, all my Wi-Fi goes off for the night. And that includes nest and everything. So I set it up so during those hours of sleeping, they are not on, number one. And number two, I have— I used a very, very high-end EMF meter and I’ve tested the nest and such and really, the EMF comes out in those first 10 feet or so, away from it.
Evan Brand: Yeah.
Dr. Justin Marchegiani: So I’ve been across the room or sitting in my couch and I aim it at that or it get caught and it’s few—and it take—you got to be pretty close to get that EMF out.
Evan Brand: Yeah.
Dr. Justin Marchegiani: You really do.
Evan Brand: Yeah. Distance. I think your distance should probably much safer. I started doing the Wi-Fi on a timer, then I thought, “What the hell, if I’m sleeping better without it, what am I sacrificing during the day being at home with it. So that's why I’ve just went hardwired. Maybe I'll go back, but for now, I’m hardwired and I feel pretty good.
Dr. Justin Marchegiani: Yeah. I mean—its just, like for me, like I’m at the airport, I’m coming in and it's like my house is like a hundred degrees. I’m like, “Oh, let’s get it cool, or like, you know, we go away and if like uhm—we’re out of the house, right? It'll take the temperature up a little bit.
Evan Brand: Right.
Dr. Justin Marchegiani: You save a little bit of money on—on that side of the fence. So there’s pros and cons. I think uhm—if you can like—I’m hardwired right now. But I think if you can put your thing on a Christmas tree timer at night, I think you really, you know, you can at least have it off when you're sleeping, which I think is really important. I also sleep on a ground and I have EMF blockers in my room as well.
Evan Brand: Yep. For sure. Let's keep going. Uh—let’s see what else we've got here.“What are some blood test markers for thyroid issues?” I believe we did a whole podcast on this.
Dr. Justin Marchegiani: Yeah. I would see the whole podcast on that. TSH, T4, T3. Real quick, TSH, you know, below 2.5; 1's ideal; T4 free: 1 to 1.5; T4 total: 6 to 10; T3 total: 100 to like 150-160. Again, go see the podcast on that. We’ve riffed on it for over an hour at a time, so check that out.
Evan Brand: Yeah. Another question is “Redmond's real salt worth it if you’re having pink Himalayan salt?” I think so. I switch out. I have a lot of salt Celtic sea salt, I've got all sorts of different types and flavors and sources. I think they're all helpful and they’re not gonna hurt you. It’s in that category of my help— not hurt you.
Dr. Justin Marchegiani: Yeah. And I think, Redmond’s in my opinion just taste better. It dissolves really well in the water. So you throw it in there, dissolves really nice. I mean I’ve used Himalayan and Celtic— doesn't quite dissolve as good. Maybe there’s a more, uhm—you know, a version that’s ground-up better so it absorb as more soluble in water. But I like the Redmond’s. I love the taste. Love it.
Evan Brand: Yeah. It does taste good.
Dr. Justin Marchegiani: Yeah. It’s very good. And it’s lower in —
Evan Brand:—We do the same. Turn off the Wi-Fi after 10 so that’s cool like I said, I used to, but then I’m like, “Yeah, I’m gonna just get rid of Wi Fi completely especially after I was in a Dr. Klinghardt talk about “How you can detox heavy metals if you're exposed to Wi-Fi” which is pretty interesting on his latest talk. I was like, “Whoa! That’s pretty nuts, so—“
Dr. Justin Marchegiani: Yeah. I mean, I think what happens is you get some people who are the exception to the rule.
Evan Brand: Yeah.
Dr. Justin Marchegiani: Regarding their high level of sensitivity and then you get a lot of practitioners that had had success with that one person.
Evan Brand: Right.
Dr. Justin Marchegiani: And they they start— this is the rule for everyone. I think that's really excessive, but if you are chronically ill, should you try it? Heck, yeah. You should try it.
Evan Brand: Yeah.
Dr. Justin Marchegiani: But it may not be the end-all or be-all. I mean, I love the convenience of having Wi-Fi. I don’t know this as much, Evan, but I do know that, you know, I'm sleeping at night. Maybe I'll get into a little bit deeper REM sleep. So I'm not using it at night. I get no benefit by keeping it on at night. So why not just turn it off, right?
Evan Brand: Right. For sure. Uh—we got a question from Vevec. He said uh—“How to differentiate between type I and type II diabetes? Any diagnostic test?”
Dr. Justin Marchegiani: Yeah. I mean, type I is gonna be an autoimmune condition. So what’s gonna happen is uhm—typically it’s gonna happen in the first 12 to 13 years of life. That’s when it mostly happens for kiddos. And their reality tend to be behind it, but one of the big things that you're gonna see, is you’re gonna see just blood sugar just going up super, super high, right? The reason why it's going up super, super high is because the insulin isn’t there by the beta cell so it cant’ let the—the sugar get into the cell. So you see blood sugar come up super, super high. These people tend not to be big and be more small. You know, more uh—I should say smaller because they don’t have the insulin bringing the sugar into their cell to get the fat up.
Evan Brand: Yup.
Dr. Justin Marchegiani: But you can also run what’s called the C-peptide test, which will look at the uhm— the beta cell function of the pancreas. And if you see C-peptide on the lower side, uhm— then you’ll know. And you can also run uhm—type I diabetes. I think the beta cell antibodies. You can run to also confirm that too, or pancreatic isolate cell antibodies to confirm that. So there are different things you can do to assess. But you’re gonna know because you just— you're getting emaciated uhm—and your blood sugar’s off the charts high, for sure.
Evan Brand: Yup. Uh—last question we can take care. Shayna, “What is over a 115 vitamin D level? I mean I don't take a vitamin D supplement.” First, we gotta make sure that’s actually the vitamin D not the 1,25. That’s a kidney marker but the 25OHhydroxy vitamin D marker. You gotta make sure it's that one. If it's that one and you don't supplement, I'm not too sure. I’ll see if I can find something. Justin, what’s your take?
Dr. Justin Marchegiani: Yes. Same thing. I would just—I would look at what your—what the marker is. And then number two, maybe you’re getting out in the sun a lot or maybe your—one of your supplement has some vitamin D in there, you’re not aware of it coz that’s pretty high to get to naturally. So maybe you’re sunbathing a lot, maybe that’s totally natural. I would just double check that and make sure that's the case. But double check if it’s 25 versus the 125. That’s the big thing I’d say.
Evan Brand: Yeah. I mean my wife's prenatal, for example, there's a lot of vitamin D in there. Those other formulas that we've taken that have vitamin D, so you could really add up to six or eight or 10,000 IU pretty pretty quick. So, yeah, I second that. Look at your protocol. Make sure there’s nothing in there.
Dr. Justin Marchegiani: Absolutely. Let me just knock up just one more question here. So regarding alkaline phosphatase—Yeah, less than 50 is low zinc. Again alkaline phosphatase is an enzyme that correlates with zinc. So it's— it's a metalloenzyme so when the enzyme’s lower, we tend to have lower zinc. You can also test it Zinc Tally test get some zinc—I think it’s zinc chloride or zinc sulfate.
Evan Brand: Yup.
Dr. Justin Marchegiani: It’s the liquid zinc. And then basically the better it tastes, the cleaner and the more like water it tastes, the less you need it. I’m sorry—the more you need it—the more you need it. The more metallically it tastes, and you know, the more metal it tastes, the less you need it. So that’s a good kinda rule over time to kinda look at. And then A1C—again is a marker for blood sugar. If A1Cis really low, right? We want to look at other markers to correlate anemia. So if we see MCV, MCH, MCHC on the higher side, that could be in some kind of B vitamin anemia or if we see RBC hematocrit hemoglobin below, that could be another indicator for an anemia.
Evan Brand: Oh, we got one more question and then we’ll have to wrap it up. It just gets addicting answering questions.
Dr. Justin Marchegiani: Yeah.
Evan Brand: Abner—he has buddies telling him it's ideal to spike insulin before weight training. Is there any benefits to it? I mean, I've always thought the exact opposite that you want to have a little bit of a spike after—
Dr. Justin Marchegiani: Post work out training.
Evan Brand: –weight training.
Dr. Justin Marchegiani: Post work out. The reason why is people are incredibly anabolic. Most people that have high levels of insulin, it’s anabolic in the terms of uh—generating fat cells, right? Coz anabolic means to grow in fat cells. But if you can use insulin post work out, you can basically have the key to drive protein into the cell. You're also driving which is gonna help with, you know, protein synthesis, ideally building more muscle. It’s gonna help spike mTOR and then you’re also gonna have effects of driving sugar into the muscle, which it’s just wrung out all that glycogen during the workout. So you’re repleting the glycogen which will have some anabolic effects and it will uhm—it will help lower cortisol, too. It will drive down some of the cortisol because the cortisol has made all the blood sugar so it’s gonna pull all that sugar from the cortisol into the muscle so it can be used to help generate hypertrophy.
Evan Brand: Yup. I just did a little bit of research on vitamin D. If it's super high, it could be a buildup of calcium in the blood. So other symptoms that could go along with this could be poor appetite, nausea, vomiting, weakness, frequent urination, kidney problem. So maybe look at your other markers on your blood test. See if you got anything off with your calcium, you got anything off with some of the kidney markers and then if you’ve got those other symptoms— frequent urination, things like that, definitely take a look.
Dr. Justin Marchegiani: Yeah. It’s almost always from a supplement so just stop—stop taking the supplement if __ vitamin your body will eventually clear it out in a few days to a few weeks.
Evan Brand: Yup. It should be pretty quick. Well, cool. Any last things you wanted to say before we wrap it up. I think we did a great job on this one.
Dr. Justin Marchegiani: Yeah. This is probably my first—my last podcast uh— without a kiddo. So I’ll be officially a dad uh— next time that we are on the air. So pretty excited about that.
Evan Brand: Me too. I’m pumped for you.
Dr. Justin Marchegiani: Can you give me like one fatherly tip or advice here before we go.
Evan Brand: My fatherly advice is just you—you take it day by day and when something happens where you could see yourself stressing out, just remember you have the ability to control how you respond to something. So I like— when the baby is super fussy, and you’re trying to figure out is he tired, is he uh— hungry what is it? I just like take an extra second it's like, “Okay, let's run through the day. Okay, the last feeding was this. Okay, maybe it’s too warm in here. Maybe a little too cold.” Before I let my sympathetic nervous system kick in to overdrive, I try to walk through the situation step-by-step and then, “okay” and then that way, I don't make myself sick by the extra stress.
Dr. Justin Marchegiani: Right. So instead of getting mad at the situation, you kinda like take a step back like kinda problem solve or think what could be the issue before you have an emotional response.
Evan Brand: Exactly, dude. Try—try to not have the emotional response.
Dr. Justin Marchegiani: Right. Try to be more—more logical than emotional about it.
Evan Brand: Which can be hard when you're tired, and your sleep is interrupted and stuff like that, but you just get better and better every day at it.
Dr. Justin Marchegiani: Appreciate it, man. Excellent.
Evan Brand: Yup.
Dr. Justin Marchegiani: Hey, today was a great chat. Let’s do more, probably in the next two weeks here, but maybe I'll jump on here while my little paternity leave here for the week.
Evan Brand: No rush, man. You deserve it. You earned it. Take that paternity leave. Will be here waiting for you when you get back and uh—if people want to schedule, in the meantime with Justin, may be a little bit till he gets back. Til his back in the trench but uh—justinhealth.com He will be ready and willing and for me, evanbrand.com you can schedule with either of us. In the meantime, make sure you subscribe if you're watching on YouTube and we’ll chat with you again soon.
Dr. Justin Marchegiani: It will be a lot of sleep in down time so maybe I can sink one up in there, so we can have a chat in between.
Evan Brand: Sounds good.
Dr. Justin Marchegiani: Alright, Evan. Great chat. You have a great day.
Evan Brand: Take care.
Dr. Justin Marchegiani: Take care. Bye.
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